SEPN Company Profile and Key Details

NASDAQ : SEPN

Septerna

$33.49

-1.26-3.63%

At Close 4:00 PM

Profile Key Stats Analyst Ratings Ownership Ratios Financials Dividend & splits Sentiment Forecast

Price Chart

Stock Price Today

Septerna Inc (SEPN) stock declined over -3.63%, trading at $33.49 on NASDAQ, down from the previous close of $34.75. The stock opened at $34.01, fluctuating between $32.65 and $34.73 in the recent session.

Stock Snapshot

34.75

Prev. Close

1.51B

Market Cap

32.65

Day Low

-31.01

P/E Ratio

-1.08

EPS (TTM)

N/A

Cash Flow per Share

34.01

Open

45.08M

Number of Shares

34.725

Day High

40.78%

Free Float in %

N/A

Book Value

747.21K

Volume

Relevant Articles

SEC Fillings

Current Report (8-k)

Filing Date	Accepted Date

Annual Report (10-k)

Filing Date	Accepted Date

Stock Price History Chart

Date	Open	High	Low	Close	Volume
Jun 30, 2026	34.69	34.78	32.65	33.49	747.64K
Jun 29, 2026	35.18	35.99	32.00	34.75	1.43M
Jun 26, 2026	34.44	37.48	34.23	37.34	1.48M
Jun 25, 2026	36.36	36.40	34.35	34.54	324.46K
Jun 24, 2026	36.90	37.99	35.61	36.05	357.55K
Jun 23, 2026	34.67	37.50	34.28	36.57	301.5K
Jun 22, 2026	36.46	37.24	34.68	34.85	506.96K
Jun 18, 2026	36.24	37.32	34.51	36.17	283.32K
Jun 17, 2026	35.17	36.12	33.88	35.80	325.04K
Jun 16, 2026	35.93	36.62	35.06	35.17	283.11K
Jun 15, 2026	36.27	37.01	35.37	36.03	287.77K
Jun 12, 2026	34.03	36.26	33.85	35.95	475.86K
Jun 11, 2026	30.86	34.19	30.74	34.03	512.76K
Jun 10, 2026	31.00	31.98	30.41	30.47	171.88K
Jun 09, 2026	30.69	31.90	30.30	31.01	270.83K
Jun 08, 2026	31.97	32.38	30.05	30.41	327.22K
Jun 05, 2026	30.99	31.41	30.47	31.15	211.65K
Jun 04, 2026	30.61	31.79	30.61	31.37	290.67K
Jun 03, 2026	29.89	30.84	29.57	30.55	282.06K
Jun 01, 2026	29.59	30.36	27.08	29.98	359.29K

Contact Details

South San Francisco, CA 94080

United States

https://septerna.com 650 338 3533

About Company

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves’ disease and thyroid eye disease. In addition, it focuses on other therapeutic areas, including neurology, women’s health, cardiovascular disease, and respiratory disease. It has global collaboration and license agreement with Novo Nordisk to discover, develop and commercialize multiple potential oral small molecule therapies for metabolic-related diseases based on certain specified molecular targets. The company was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.

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Company Overview

Septerna Inc (NASDAQ:SEPN) closed at $33.49 USD, losing -$1.26 (-3.63%) from the previous close of $34.75. The stock is currently mid-range between its 52-week high and low $10.30 and $37.99. With a market capitalization of about $1.51 billion, Septerna Inc is classified as a small-cap and shows higher-than-market volatility (beta ~2.38). Key stats such as the average daily volume over the past year has been around 367.36 thousand shares, trading with heavier-than-usual volume. Headquartered in South San Francisco, CA, Septerna Inc operates in the Healthcare sector and the Biotechnology industry. Led by CEO Jeffrey T. Finer, the company employs approximately 130 people and listed since October 25, 2024. Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases.

Technical Performance

SEPN has shown sold momentum, gaining 8.64% over the past week and 22.53% over the past quarter, though year-to-date performance is down -3.05%. Short-term trend indicators are mixed aligned (SMA20 12.68%, SMA50 12.62%, SMA200 63.11%). The stock’s 14-day RSI is 61.22 (firm momentum), while the ATR of 1.91 points to higher daily volatility. The stock remains hovering near 52-week lows, trading -7.2% below its high and over 549.79% above its low. Average 10-day trading volume of 735.81 thousand shares is significantly above the 3-month average of 358.03 thousand, indicating heightened recent market interest.

Valuation Metrics

Septerna Inc trades at a P/E ratio of -41.4, slightly below the S&P 500 average, with a price-to-sales ratio of 20.92 and a price-to-book ratio of 3.97 trading at moderately above to book value. The P/FCF stands at 14.13, also above market averages.

Dividend & Fair Value

Septerna Inc last paid a dividend of 0 per share, Dividend and splits history remains an important factor for investors monitoring long-term returns. A discounted cash flow model estimates fair value at around -$32.35. This means the shares are trading below this model’s fair value.

Earnings & Analyst Outlook

Wall Street analysts project EPS growth of 36.02% annually over the next five years. Analyst sentiment is bullish. Analyst rating data shows there are 6 Strong Buy ratings, 9 Buy ratings, 0 Hold ratings, 0 Sell rating and 0 Strong Sell ratings. Price targets range from $53.00 to $25.00. The high target offers 58.26% upside. The low target suggests -25.35% downside. The mean target is $36.87. This offers 10.09% upside. Septerna Inc earnings surprise history is a mixed track record. The quarter that ended May 12, 2026, missed forecasts by -54.4%. The prior quarter beat by 4.35%. Over the last six quarters, Apple has recorded several small beats. These include -7.25% in March 27, 2025.

Shareholding & Insider Activity

Septerna Inc has 44.59 million shares outstanding. The public float is 18.18 million shares, elevated short interest at 12.31% of float. This equals 3.17 million shares. The short ratio is 12.22 days. Institutional investors hold 106.02% of the float. Insiders own 3.17%. Bhatt Elizabeth holds 174.21 thousand shares, Long Daniel D. has 96.41 thousand shares and Shaikhly Samira has 793.00 shares. Over the past six months, insider transactions show net selling. They sold 96.43 thousand shares across 7 transactions.

Financial & Profitability Overview

Over the trailing twelve months, Septerna has not generated any revenue.
On valuation metrics, Septerna trades at a P/E of -41.40, P/S of 20.92 and P/B of 3.97. The current ratio is 4.71 and quick ratio is 4.71. Operationally, the company’s inventory turnover is 0.00 and cash conversion cycle is -6398.98 days , indicating it collects cash faster than it pays suppliers. Debt-to-equity is 0.06, supported by a cash flow-to-debt ratio of 4.67.

Price Forecast & Outlook

Our AI price prediction model suggests that Septerna Inc stock has strong potential for upside but may face short-term weakness followed by gains in the medium and long term. 2-Week Outlook: Projected increase of 17.44%, with price expected at $39.33 by July 13, 2026, within a range of $37.87 to $40.71 3-Month Outlook: Projected fall of -26.81%, reaching $24.51 by September 25, 2026, with a range of $21.97 to $26.59. 1-Year Outlook: Projected gain of 33.65%, with price at $44.76 by June 29, 2027, within a range of $42.15 to $47.22.

Key Takeaways

Septerna Inc (NASDAQ:SEPN) shares are flat -3.05% year-to-date currently trading near 52-week highs band. Short-term momentum has been positive over the last quarter, despite recent volatility. Valuation shows Septerna Inc trading at a premium to the broader market with a P/E of -41.4. Analyst sentiment is cautious, with the majority of ratings in Strong Buy territory and a mean price target of $35.68, suggesting 6.54% upside. Our AI forecast model points to short-term strength (17.44% over two weeks), a medium-term fall (-26.81% over three months), and a longer-term gain (33.65% over one year), with expected trading ranges indicating moderate volatility.

Frequently Asked Questions

What is the current Septerna Inc (SEPN) stock price?

Septerna Inc (NASDAQ: SEPN) stock price is $33.49 in the last trading session. During the trading session, SEPN stock reached the peak price of $34.73 while $32.65 was the lowest point it dropped to. The percentage change in SEPN stock occurred in the recent session was -3.63% while the dollar amount for the price change in SEPN stock was - $1.26.

SEPN's industry and sector of operation?

The NASDAQ listed SEPN is part of Biotechnology industry that operates in the broader Healthcare sector. Septerna Inc designs, manufactures, and markets smartphones, personal computers, tablets, wearables, and accessories worldwide.

Who are the executives of SEPN?

No Data

How SEPN did perform over past 52-week?

SEPN's closing price is 225.15% higher than its 52-week low of $10.30 where as its distance from 52-week high of $37.99 is -11.85%.

How many employees does SEPN have?

Number of SEPN employees currently stands at 130.

Link for SEPN official website?

Official Website of SEPN is: https://septerna.com

How do I contact SEPN?

SEPN could be contacted at phone 650 338 3533 and can also be accessed through its website. SEPN operates from 250 East Grand Avenue, South San Francisco, CA 94080, United States.

How many shares of SEPN are traded daily?

SEPN stock volume for the day was 747.21K shares. The average number of SEPN shares traded daily for last 3 months was 367.36K.

What is the market cap of SEPN currently?

The market value of SEPN currently stands at $1.51B with its latest stock price at $33.49 and 45.08M of its shares outstanding.

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Employees	130
Beta	2.38
Sales or Revenue	N/A
5Y Sales Change%	0%
Fiscal Year Ends	N/A
Sector	Healthcare
Industry	Biotechnology

SEPN Company Profile and Key Details

Septerna

Price Chart

Stock Price Today

Stock Snapshot

Relevant Articles

SEC Fillings

Current Report (8-k)

Annual Report (10-k)

Stock Price History Chart

Contact Details

About Company

Company Information

Stock Peers

Company Overview

Technical Performance

Valuation Metrics

Dividend & Fair Value

Earnings & Analyst Outlook

Shareholding & Insider Activity

Financial & Profitability Overview

Price Forecast & Outlook

Key Takeaways

Frequently Asked Questions

Technical Performance

Shareholding & Insider Activity

Earnings & Analyst Outlook

Dividend & Fair Value

Company Overview

Financial & Profitability Overview

Valuation Metrics

Key Takeaways

Price Forecast & Outlook