SEPN Company Profile and Key Details

SEPN has shown sold momentum, gaining 8.64% over the past week and 22.53% over the past quarter, though year-to-date performance is down -3.05%. Short-term trend indicators are mixed aligned (SMA20 12.68%, SMA50 12.62%, SMA200 63.11%). The stock’s 14-day RSI is 61.22 (firm momentum), while the ATR of 1.91 points to higher daily volatility. The stock remains hovering near 52-week lows, trading -7.2% below its high and over 549.79% above its low. Average 10-day trading volume of 360.65 thousand shares is slightly above the 3-month average of 286.84 thousand, indicating heightened recent market interest.

Septerna, Inc. has 44.59 million shares outstanding. The public float is 18.18 million shares, elevated short interest at 12.31% of float. This equals 3.17 million shares. The short ratio is 12.22 days. Institutional investors hold 106.31% of the float. Insiders own 3.14%. Bhatt Elizabeth holds 174.21 thousand shares, Long Daniel D. has 92.91 thousand shares and Shaikhly Samira has 793.00 shares. Over the past six months, insider transactions show net selling. They sold 71.99 thousand shares across 4 transactions.

Wall Street analysts project EPS growth of 36.02% annually over the next five years. Analyst sentiment is bullish. Analyst rating data shows there are 5 Strong Buy ratings, 9 Buy ratings, 0 Hold ratings, 0 Sell rating and 0 Strong Sell ratings. Price targets range from $48.00 to $25.00. The high target offers 83.7% upside. The low target suggests -4.32% downside. The mean target is $34.71. This offers 32.84% upside. Septerna, Inc. earnings surprise history is a mixed track record. The quarter that ended November 10, 2025, missed forecasts by -147.37%. The prior quarter beat by 1020.0%. Over the last six quarters, Apple has recorded several small beats. These include 1111.54% in November 20, 2024.

Septerna, Inc. last paid a dividend of 0 per share, Dividend and splits history remains an important factor for investors monitoring long-term returns. A discounted cash flow model estimates fair value at around -$20.83. This means the shares are trading below this model’s fair value.

Septerna, Inc. (NASDAQ:SEPN) closed at $26.04 USD, losing -$0.09 (-0.34%) from the previous close of $26.13. The stock is currently mid-range between its 52-week high and low $5.73 and $32.63. With a market capitalization of about $1.17 billion, Septerna, Inc. is classified as a small-cap and shows higher-than-market volatility (beta ~3.50). Key stats such as the average daily volume over the past year has been around 302.37 thousand shares, in line with its 52-week average. Headquartered in South San Francisco, CA, Septerna, Inc. operates in the Healthcare sector and the Biotechnology industry. Led by CEO Jeffrey T. Finer, the company employs approximately 75 people and listed since October 25, 2024. Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products candidates for the treatment of endocrinology, immunology and inflammation, and metabolic diseases.

Septerna, Inc. (NASDAQ:SEPN) shares are flat -3.05% year-to-date currently trading near 52-week highs band. Short-term momentum has been positive over the last quarter, despite recent volatility. Valuation shows Septerna, Inc. trading at a premium to the broader market with a P/E of -23.66. Analyst sentiment is bullish, with the majority of ratings in Buy territory and a mean price target of $34.60, suggesting 32.41% upside. Our AI forecast model points to short-term weakness (-3.98% over two weeks), a medium-term rise (92.35% over three months), and a longer-term gain (22.43% over one year), with expected trading ranges indicating moderate volatility.

Our AI price prediction model suggests that Septerna, Inc. stock has strong potential for upside but may face short-term weakness followed by gains in the medium and long term. 2-Week Outlook: Projected decline of -3.98%, with price expected at $25.09 by May 01, 2026, within a range of $24.12 to $26.06 3-Month Outlook: Projected rise of 92.35%, reaching $50.26 by July 16, 2026, with a range of $49.65 to $51.28. 1-Year Outlook: Projected gain of 22.43%, with price at $31.99 by April 16, 2027, within a range of $29.78 to $34.59.

Septerna, Inc. trades at a P/E ratio of -23.66, slightly below the S&P 500 average, with a price-to-sales ratio of 25.54 and a price-to-book ratio of 3.03 trading at moderately above to book value. The P/FCF stands at 10.7, also above market averages.