How many institutions own SEPN stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own SEPN shares is 128, representing 100.83% of the company's common stock.

Who are the major shareholders selling Septerna, Inc. stock?

RANGELEY CAPITAL, LLC, in the last quarter, reduced its stake in SEPN by -25.23% restricting it's holding to 65.8 thousand shares of worth nearly $1.83M. ADVISOR GROUP HOLDINGS, INC. also lessened -1.32% of the SEPN shares from its portfolio, reducing its holding to 12.69 thousand shares of worth $353.88K. PERCEPTIVE ADVISORS LLC also shunned SEPN shares holding by -20% last quarter which brought its holding to 433.16 thousand shares worth $12.08M.

Investors who are buying SEPN stock?

As per its latest 13F filing, JPMORGAN CHASE & CO increased its stake in SEPN by 682.26% in the last quarter. The institutional holder raised its holding to 68.34 thousand shares having worth more than $1.91M. UBS GROUP AG also added 16.55% more shares of SEPN to its portfolio, raising its holding to 68.82 thousand shares of worth $1.92M. HIGHVISTA STRATEGIES LLC also increased its SEPN shares holding by 100% which brought its holding to 78.68 thousand shares worth $2.19M.

SEPN's major insiders: who are they?

The insider with the most stakes in SEPN is Bhatt Elizabeth , President and COO at the company. Additionally, SEPN stock is highly held by SVP, Drug Discovery Long Daniel D. and N/A N/A among others.

Did an insider recently sell SEPN stock?

Company executives, directors, and other insiders own 3.15% percent of Septerna, Inc.'s stock. Within the last six months, there have been 2 transaction(s) in which SEPN insiders have sold stock, totaling 5.3K shares. Insiders that have sold shares include BHATT ELIZABETH and LONG DANIEL D..

Which insider recently purchased SEPN stock?

There have been 0 transaction(s) during the past 6-months in which Septerna, Inc. insiders have bought stock, totalling 0 shares

How much of SEPN does insiders own?

Around 267.12K Septerna, Inc. shares are held by insiders, which represents about 3.15% of SEPN stock.

Who is the insider with the largest stake?

SEPN President and COO, Bhatt Elizabeth holds the largest portfolio of the company's shares. SEPN shares owned by Bhatt total nearly 174.21 thousand.

Which institution holds the most shares in SEPN?

RANGELEY CAPITAL, LLC is the largest institutional owner in SEPN which holds 65.8 thousand shares worth $1.83M or 0.15% of the total SEPN shares outstanding followed by JPMORGAN CHASE & CO with ownership of 68.34 thousand shares representing 0.15% of the SEPN ownership. UBS GROUP AG is the third largest stakeholder with 68.82 thousand shares or 0.16% of the ownership worth more than $1.92M.

Is Septerna, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the SEPN is concerned, it is a stock which is optionable.

Is there a short position on SEPN's shares?

Number of SEPN shares short is 3.17M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding SEPN shares are there?

As of today, 44.59M shares of SEPN are outstanding.

Is there many float in SEPN stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, SEPN has 18.18M shares in float.

SEPN short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for SEPN is 12.22.

Septerna (SEPN) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares7.12

Short Percent Of Float12.31

Shares Outstanding44.59M

Shares Float18.18M

Shares Short3.17M

Short Ratio12.22

12.31%

Short % of Float

7.12%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

3.15% Percentage of Shares held by All Insiders

100.83% Percentage of Shares held by All Institutions

104.11% Percentage of Float held by Institutions

128

Number of Institutions Holding Shares

Institutional Ownership

About 100.83% of SEPN shares are held by financial institutions. RANGELEY CAPITAL, LLC is the top corporate investor, holding 65.8K shares valued at $1.83M. A 0.15% stake in Septerna, Inc. is owned by the company. JPMORGAN CHASE & CO owns 68.34K shares valued at $1.91M, which translates its holding of 0.15% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	RANGELEY CAPITAL, LLC	0.15%	65.8K	1.83M	-22.2K	-25.23%
Dec 31, 2025	JPMORGAN CHASE & CO	0.15%	68.34K	1.91M	59.6K	+682.26%
Dec 31, 2025	UBS GROUP AG	0.16%	68.82K	1.92M	9.77K	+16.55%
Dec 31, 2025	HIGHVISTA STRATEGIES LLC	0.18%	78.68K	2.19M	78.68K	+100.00%
Dec 31, 2025	FEDERATED HERMES, INC.	0.18%	78.91K	2.2M	78.91K	+100.00%
Dec 31, 2025	MORGAN STANLEY	0.23%	103.99K	2.9M	49.53K	+90.95%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.42%	187.24K	5.22M	337	+0.18%
Dec 31, 2025		0.44%	194.54K	5.42B	194.54K	+100.00%
Dec 31, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.5%	222.7K	6.21M	0	0
Dec 31, 2025	ADVISOR GROUP HOLDINGS, INC.	0.03%	12.69K	353.88K	-170	-1.32%
Dec 31, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	13.28K	370.33K	13.28K	+100.00%
Dec 31, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	13.69K	381.54K	0	0
Dec 31, 2025	SQUAREPOINT OPS LLC	0.03%	14.85K	413.93K	14.85K	+100.00%
Dec 31, 2025	FRANKLIN RESOURCES INC	0.04%	16.85K	469.83K	16.85K	+100.00%
Dec 31, 2025	TUDOR INVESTMENT CORP ET AL	0.04%	18.05K	503.32K	18.05K	+100.00%
Dec 31, 2025	MARSHALL WACE, LLP	0.51%	226.9K	6.33M	226.9K	+100.00%
Dec 31, 2025	CATALIO CAPITAL MANAGEMENT, LP	0.66%	294.36K	8.21M	0	0
Dec 31, 2025	WOODLINE PARTNERS LP	0.87%	385.31K	10.74M	102.73K	+36.35%
Dec 31, 2025	PERCEPTIVE ADVISORS LLC	0.98%	433.16K	12.08M	-108.29K	-20.00%
Dec 31, 2025	CASDIN CAPITAL, LLC	1.25%	553.27K	15.43M	0	0
Dec 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	2.61%	1.16M	32.27M	-18.88K	-1.60%
Dec 31, 2025	AVORO CAPITAL ADVISORS LLC	3.02%	1.34M	37.29M	0	0
Dec 31, 2025	SAMSARA BIOCAPITAL, LLC	7.1%	3.15M	87.8M	0	0
Dec 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	10.85%	4.81M	134.09M	-110.43K	-2.24%
Dec 31, 2025	RHUMBLINE ADVISERS	0.06%	26.42K	736.55M	-1.19K	-4.29%
Dec 31, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.04%	18.55K	398.64K	18.55K	+100.00%
Dec 31, 2025	RA CAPITAL MANAGEMENT, L.P.	15.78%	7M	195.04M	0	0
Dec 31, 2025	BVF INC/IL	3.88%	1.72M	47.98M	-2.3M	-57.15%
Dec 31, 2025	FIRST LIGHT ASSET MANAGEMENT, LLC	1.4%	620.81K	17.31M	620.81K	+100.00%
Dec 31, 2025	VR ADVISER, LLC	1.38%	610.81K	17.03M	0	0
Dec 31, 2025	NORTHERN TRUST CORP	0.35%	154.2K	4.3M	-13.15K	-7.86%
Dec 31, 2025	XTX TOPCO LTD	0.05%	23.32K	650.02K	23.32K	+100.00%
Dec 31, 2025	LOGOS GLOBAL MANAGEMENT LP	0.05%	23.55K	656.52K	-60K	-71.82%
Dec 31, 2025	INVESCO LTD.	0.37%	162.01K	4.52M	-15.06K	-8.50%
Dec 31, 2025	TWO SIGMA ADVISERS, LP	0.06%	25.7K	716.52K	5K	+24.15%
Dec 31, 2025	NUVEEN, LLC	0.06%	25.8K	719.25K	1.84K	+7.67%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.06%	26.53K	739.63K	6.38K	+31.68%
Dec 31, 2025	ACADIAN ASSET MANAGEMENT LLC	0.07%	30.88K	858K	30.88K	+100.00%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	0.08%	37.59K	1.05M	-13.9K	-26.99%
Dec 31, 2025	BARCLAYS PLC	0.09%	38.15K	1.06M	8.05K	+26.73%
Dec 31, 2025	AMERICAN CENTURY COMPANIES INC	0.11%	50.69K	1.41M	25.41K	+100.49%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.12%	55.33K	1.54M	3.7K	+7.17%
Dec 31, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	0.14%	61.37K	1.71M	25.59K	+71.53%
Dec 31, 2025	JANE STREET GROUP, LLC	0.1%	44.07K	1.23M	44.07K	+100.00%
Dec 31, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.86%	383.37K	10.69M	365.11K	+1,999.50%
Dec 31, 2025	GLOBAL RETIREMENT PARTNERS, LLC	0%	1.26K	35.02K	1.26K	+100.00%
Dec 31, 2025	CAITONG INTERNATIONAL ASSET MANAGEMENT CO., LTD	0%	1.9K	53K	1.9K	+100.00%
Dec 31, 2025	COVESTOR LTD	0%	1.94K	54K	-1.68K	-46.38%
Dec 31, 2025	AMERITAS INVESTMENT PARTNERS, INC.	0%	1.94K	54.2K	0	0
Dec 31, 2025	STATE STREET CORP	1.22%	540.03K	15.06M	121.07K	+28.90%
Dec 31, 2025	PRIMECAP MANAGEMENT CO/CA/	1.23%	546.1K	15.23M	546.1K	+100.00%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.29%	572.73K	15.97M	27.03K	+4.95%
Dec 31, 2025	VANGUARD GROUP INC	3.4%	1.51M	42.05M	-10.56K	-0.70%
Dec 31, 2025	BLACKROCK, INC.	4.06%	1.8M	50.22M	341.53K	+23.40%
Dec 31, 2025	SIREN, L.L.C.	4.51%	2M	55.76M	-202.51K	-9.19%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	6.12%	2.72M	75.7M	1.26M	+86.64%
Dec 31, 2025	TRV GP VI, LLC	9.5%	4.21M	117.42M	0	0
Dec 31, 2025	TRV GP V, LLC	14.02%	6.22M	173.29M	0	0
Dec 31, 2025	VIRTUS INVESTMENT ADVISERS, INC.	0.02%	10.46K	291.54K	10.46K	+100.00%
Dec 31, 2025	DYNAMIC TECHNOLOGY LAB PRIVATE LTD	0.02%	10.81K	301K	10.81K	+100.00%
Dec 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.08%	35K	975.8K	0	0
Dec 31, 2025	DEUTSCHE BANK AG\	0.03%	14.88K	414.83K	744	+5.26%
Dec 31, 2025	STRS OHIO	0.03%	14.6K	407.05K	14.6K	+100.00%
Dec 31, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	10.3K	287.05K	10.3K	+100.00%
Dec 31, 2025	BAADER BANK AKTIENGESELLSCHAFT	0.02%	10K	278.8K	10K	+100.00%
Dec 31, 2025	CITIGROUP INC	0.02%	9.56K	266.56K	9.31K	+3,739.76%
Dec 31, 2025	JUMP FINANCIAL, LLC	0.02%	8.4K	234.16K	8.4K	+100.00%
Dec 31, 2025	BANK OF NOVA SCOTIA	0.02%	8.3K	231.4K	8.3K	+100.00%
Dec 31, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.01%	5.6K	156.13K	2.7K	+93.10%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.01%	5.45K	151.92K	1.29K	+31.14%
Dec 31, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.01%	5.18K	144.28K	0	0
Dec 31, 2025	CITADEL ADVISORS LLC	0.17%	75.95K	2.12M	75.95K	+100.00%
Dec 31, 2025	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0%	2.18K	60.67K	2.18K	+100.00%
Dec 31, 2025	LEGAL & GENERAL GROUP PLC	0%	1.95K	54.17K	0	0
Dec 31, 2025	TWO SIGMA INVESTMENTS, LP	0.21%	92.81K	2.59M	475	+0.51%
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.16%	69.2K	1.93M	-3.4K	-4.68%
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	0.24%	107.46K	3M	-276.74K	-72.03%
Dec 31, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.09%	37.87K	1.06M	37.87K	+100.00%
Dec 31, 2025	TREXQUANT INVESTMENT LP	0.1%	44.01K	1.23M	44.01K	+100.00%
Dec 31, 2025	NUMERAI GP LLC	0.1%	45.87K	1.28M	45.87K	+100.00%
Dec 31, 2025	LONGAEVA PARTNERS L.P.	0.11%	49.9K	1.39M	-7.16K	-12.55%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.05%	20.15K	378.97K	5.43K	+36.90%
Sep 30, 2025	BLACKROCK, INC.	3.31%	1.46M	27.46M	69K	+4.96%
Sep 30, 2025	BVF INC/IL	9.09%	4.02M	75.54M	-380.33K	-8.65%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	3.29%	1.45M	27.36M	38.41K	+2.71%
Sep 30, 2025	AVORO CAPITAL ADVISORS LLC	3.03%	1.34M	25.16M	100K	+8.08%
Sep 30, 2025	VR ADVISER, LLC	1.38%	610.81K	11.49M	70.36K	+13.02%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.24%	545.7K	10.27M	57.75K	+11.83%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.87%	384.2K	7.23M	332.26K	+639.64%
Sep 30, 2025	LOGOS GLOBAL MANAGEMENT LP	0.19%	83.55K	1.57M	-25.65K	-23.49%
Sep 30, 2025	WALLEYE CAPITAL LLC	0.18%	80.34K	1.51M	80.34K	+100.00%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.16%	72.6K	1.37M	45K	+163.04%
Sep 30, 2025	MORGAN STANLEY	0.12%	54.46K	1.02M	-30.4K	-35.83%
Sep 30, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.04%	18.26K	343.47K	-57.2K	-75.80%
Sep 30, 2025	TWO SIGMA ADVISERS, LP	0.05%	20.7K	389.37K	20.7K	+100.00%
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	15.84%	7M	131.59M	0	0
Sep 30, 2025	SAMSARA BIOCAPITAL, LLC	7.13%	3.15M	59.24M	0	0
Sep 30, 2025	INVESCO LTD.	0.4%	177.07K	3.33M	165.24K	+1,396.41%
Sep 30, 2025	NORTHERN TRUST CORP	0.38%	167.35K	3.15M	13K	+8.42%
Sep 30, 2025	BARCLAYS PLC	0.07%	30.1K	566.22K	-5.6K	-15.69%
Sep 30, 2025	DEUTSCHE BANK AG\	0.03%	14.14K	265.88K	2.01K	+16.60%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	13.69K	257.42K	0	0
Sep 30, 2025	ADVISOR GROUP HOLDINGS, INC.	0.03%	12.86K	241.95K	12.65K	+5,910.75%
Sep 30, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0.02%	9.79K	184.17K	-1.91K	-16.29%
Sep 30, 2025	JPMORGAN CHASE & CO	0.02%	8.74K	164.32K	-1.37K	-13.51%
Sep 30, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.01%	5.18K	97.34K	1.62K	+45.57%
Sep 30, 2025	TRV GP V, LLC	14.07%	6.22M	116.92M	0	0
Sep 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	11.14%	4.92M	92.54M	239.47K	+5.12%
Sep 30, 2025	TRV GP VI, LLC	9.54%	4.21M	79.22M	0	0
Sep 30, 2025	SIREN, L.L.C.	4.99%	2.2M	41.43M	0	0
Sep 30, 2025	VANGUARD GROUP INC	3.44%	1.52M	28.57M	104.39K	+7.38%
Sep 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	2.66%	1.18M	22.13M	329.26K	+38.86%
Sep 30, 2025	CASDIN CAPITAL, LLC	1.25%	553.27K	10.41M	0	0
Sep 30, 2025	PERCEPTIVE ADVISORS LLC	1.23%	541.45K	10.18M	0	0
Sep 30, 2025	STATE STREET CORP	0.95%	418.96K	7.88M	48.97K	+13.23%
Sep 30, 2025	JANE STREET GROUP, LLC	0.8%	352.4K	6.63M	-95.9K	-21.39%
Sep 30, 2025	CATALIO CAPITAL MANAGEMENT, LP	0.67%	294.36K	5.54M	0	0
Sep 30, 2025	WOODLINE PARTNERS LP	0.64%	282.59K	5.32M	0	0
Sep 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.5%	222.7K	4.19M	0	0
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.21%	92.33K	1.74M	14.69K	+18.92%
Sep 30, 2025	RANGELEY CAPITAL, LLC	0.2%	88K	1.66M	29.4K	+50.16%
Sep 30, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	0.08%	35.78K	672.98K	35.78K	+100.00%
Sep 30, 2025	RHUMBLINE ADVISERS	0.06%	27.6K	519.22K	-968	-3.39%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.06%	25.28K	475.57K	25.28K	+100.00%
Sep 30, 2025	NUVEEN, LLC	0.05%	23.96K	450.71K	-34.01K	-58.67%
Sep 30, 2025	VERITION FUND MANAGEMENT LLC	0.05%	20.13K	378.66K	20.13K	+100.00%
Sep 30, 2025	UBS GROUP AG	0.13%	59.05K	1.11M	-13.29K	-18.37%
Sep 30, 2025	LONGAEVA PARTNERS L.P.	0.13%	57.06K	1.07M	57.06K	+100.00%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.12%	51.63K	971.18K	3.14K	+6.48%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.01%	4.16K	78.16K	1.95K	+88.01%
Sep 30, 2025	COVESTOR LTD	0.01%	3.62K	68K	1.3K	+55.77%
Sep 30, 2025	FMR LLC	0.01%	3.44K	64.67K	953	+38.35%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.01%	2.9K	54.55K	0	0
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0%	1.95K	36.59K	0	0
Sep 30, 2025	AMERITAS INVESTMENT PARTNERS, INC.	0%	1.94K	36.57K	0	0
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0%	1.9K	35.66K	1.9K	+100.00%
Sep 30, 2025	GROUP ONE TRADING, L.P.	0%	1.69K	31.77M	900	+114.07%
Sep 30, 2025	STERLING CAPITAL MANAGEMENT LLC	0%	1.48K	27.75K	898	+155.63%
Sep 30, 2025	SIGNATUREFD, LLC	0%	966	18.17K	0	0
Sep 30, 2025	CWM, LLC	0%	884	17K	12	+1.38%
Sep 30, 2025	GAMMA INVESTING LLC	0%	804	15.12K	227	+39.34%
Sep 30, 2025	AMALGAMATED BANK	0%	634	12K	0	0
Sep 30, 2025	US BANCORP \DE\	0%	265	4.99K	0	0
Sep 30, 2025	VERSANT CAPITAL MANAGEMENT, INC	0%	261	4.91K	261	+100.00%
Sep 30, 2025	CITIGROUP INC	0%	249	4.68K	-6.92K	-96.53%
Sep 30, 2025	PNC FINANCIAL SERVICES GROUP, INC.	0%	198	3.72K	198	+100.00%
Sep 30, 2025	NISA INVESTMENT ADVISORS, LLC	0%	143	2.69K	0	0
Sep 30, 2025	FORTITUDE FAMILY OFFICE, LLC	0%	71	1.34K	0	0
Sep 30, 2025	EVERSOURCE WEALTH ADVISORS, LLC	0%	63	1.19K	41	+186.36%
Sep 30, 2025	SBI SECURITIES CO., LTD.	0%	50	941	0	0
Sep 30, 2025	ROTHSCHILD INVESTMENT LLC	0%	30	564	0	0
Sep 30, 2025	STRS OHIO	0%	0	-	-3.4K	-100.00%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0%	0	-	-12.2K	-100.00%
Sep 30, 2025	GSA CAPITAL PARTNERS LLP	0%	0	-	-23.53K	-100.00%
Sep 30, 2025	SIMPLEX TRADING, LLC	0%	0	-	-23.53K	-100.00%
Sep 30, 2025	QUADRATURE CAPITAL LTD	0%	0	-	-10.13K	-100.00%
Sep 30, 2025	CHECKPOINT CAPITAL L.P.	0.64%	283.16K	5.33M	-303.32K	-51.72%
Sep 30, 2025	SIO CAPITAL MANAGEMENT, LLC	0.43%	189.2K	3.56M	-395.24K	-67.63%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.42%	186.9K	3.52M	32.12K	+20.75%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.12%	51.5K	968.62K	-47.72K	-48.10%
Sep 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.08%	35K	658.35K	0	0
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.06%	27.42K	516K	2.52K	+10.13%
Sep 30, 2025	ALLIANCEBERNSTEIN L.P.	0.05%	22.1K	415.7K	0	0
Jun 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.5%	222.7K	2.35M	119.95K	+116.74%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.1%	487.96K	5.16M	78.32K	+19.12%
Jun 30, 2025	WOODLINE PARTNERS LP	0.64%	282.59K	2.99M	-300K	-51.49%
Jun 30, 2025		0.13%	57.97K	612.75K	34.01K	+141.94%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.35%	154.78K	1.64M	36.33K	+30.67%
Jun 30, 2025	NORTHERN TRUST CORP	0.35%	154.34K	1.63M	-3.7K	-2.34%
Jun 30, 2025	DEEP TRACK CAPITAL, LP	0.28%	121.72K	1.29M	-1.79M	-93.64%
Jun 30, 2025	LOGOS GLOBAL MANAGEMENT LP	0.25%	109.2K	1.15M	-25K	-18.63%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.22%	99.21K	1.05M	87.65K	+758.32%
Jun 30, 2025	TWO SIGMA INVESTMENTS, LP	0.18%	77.64K	820.68K	2.8K	+3.74%
Jun 30, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.17%	75.46K	797.57K	-675.9K	-89.96%
Jun 30, 2025	UBS GROUP AG	0.16%	72.34K	764.58K	-167.6K	-69.85%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.12%	51.94K	549.05K	-384.62K	-88.10%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.11%	48.49K	512.53K	10.11K	+26.35%
Jun 30, 2025	BARCLAYS PLC	0.08%	35.71K	377K	12.97K	+57.07%
Jun 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.08%	35K	369.95K	0	0
Jun 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.07%	28.7K	303.36K	28.7K	+100.00%
Jun 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.05%	24.14K	255.18K	24.14K	+100.00%
Jun 30, 2025	GSA CAPITAL PARTNERS LLP	0.05%	23.53K	249K	5.23K	+28.57%
Jun 30, 2025	SIMPLEX TRADING, LLC	0.05%	23.53K	248K	23.53K	+100.00%
Jun 30, 2025	XTX TOPCO LTD	0.05%	22.33K	236.03K	-15.02K	-40.21%
Jun 30, 2025	TUDOR INVESTMENT CORP ET AL	0.04%	16.76K	177.16K	16.76K	+100.00%
Jun 30, 2025	WELLS FARGO & COMPANY/MN	0.03%	14.72K	155.56K	3.85K	+35.40%
Jun 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	13.69K	144.65K	13.69K	+100.00%
Jun 30, 2025	CONGRESS WEALTH MANAGEMENT LLC / DE /	0.03%	12.59K	133.07K	12.59K	+100.00%
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	15.84%	7M	73.95M	0	0
Jun 30, 2025	TRV GP V, LLC	14.07%	6.22M	65.7M	0	0
Jun 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	10.6%	4.68M	49.47M	1.56M	+49.89%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	3.21%	1.42M	14.97B	-33.09K	-2.28%
Jun 30, 2025	CITADEL ADVISORS LLC	0.23%	100.6K	1.06B	89.1K	+774.78%
Jun 30, 2025	MORGAN STANLEY	0.19%	84.86K	896.97M	-6.18K	-6.79%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.05%	22.1K	233.6M	22.1K	+100.00%
Jun 30, 2025	CATALIO CAPITAL MANAGEMENT, LP	0.67%	294.36K	3.11M	-729.89K	-71.26%
Jun 30, 2025	RANGELEY CAPITAL, LLC	0.13%	58.61K	619.46K	5.66K	+10.68%
Jun 30, 2025	NUVEEN, LLC	0.13%	57.97K	612.75K	34.01K	+141.94%
Jun 30, 2025	BVF INC/IL	9.95%	4.4M	46.47M	0	0
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.06%	24.9K	264K	1.95K	+8.47%
Jun 30, 2025	RHUMBLINE ADVISERS	0.06%	28.57K	302K	5.25K	+22.53%
Jun 30, 2025	JANE STREET GROUP, LLC	1.02%	448.3K	4.74M	404.3K	+918.86%
Jun 30, 2025	AVORO CAPITAL ADVISORS LLC	2.8%	1.24M	13.08M	-100K	-7.48%
Jun 30, 2025	BLACKROCK, INC.	3.15%	1.39M	14.7M	132.49K	+10.53%
Jun 30, 2025	VANGUARD GROUP INC	3.2%	1.41M	14.95M	419.32K	+42.14%
Jun 30, 2025	SIREN, L.L.C.	4.99%	2.2M	23.28M	0	0
Jun 30, 2025	SAMSARA BIOCAPITAL, LLC	7.13%	3.15M	33.29M	0	0
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.06%	27.6K	291.73K	9.3K	+50.82%
Jun 30, 2025	CHECKPOINT CAPITAL L.P.	1.33%	586.47K	6.2M	-238.41K	-28.90%
Jun 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	1.92%	847.23K	8.96M	126.38K	+17.53%
Jun 30, 2025	VR ADVISER, LLC	1.22%	540.45K	5.71M	540.45K	+100.00%
Jun 30, 2025	PERCEPTIVE ADVISORS LLC	1.23%	541.45K	5.72M	541.45K	+100.00%
Jun 30, 2025	CASDIN CAPITAL, LLC	1.25%	553.27K	5.85M	0	0
Jun 30, 2025	SIO CAPITAL MANAGEMENT, LLC	1.32%	584.44K	6.18M	-204.24K	-25.90%
Jun 30, 2025	TRV GP VI, LLC	9.54%	4.21M	44.52M	0	0
Jun 30, 2025	STATE STREET CORP	0.84%	369.99K	3.91M	25.39K	+7.37%
Mar 31, 2025	FMR LLC	0.11%	49.78K	288.22K	-953.18K	-95.04%
Mar 31, 2025	STONEPINE CAPITAL MANAGEMENT, LLC	0.16%	68.08K	394.21K	68.08K	+100.00%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.17%	74.84K	433.33K	74.84K	+100.00%
Mar 31, 2025	MORGAN STANLEY	0.21%	91.04K	527.15K	49.13K	+117.23%
Mar 31, 2025	NORTHERN TRUST CORP	0.36%	158.04K	915.05K	10.26K	+6.95%
Mar 31, 2025	LOGOS GLOBAL MANAGEMENT LP	0.41%	134.2K	777.03K	0	0
Mar 31, 2025	UBS GROUP AG	0.55%	239.93K	1.39M	131.48K	+121.23%
Mar 31, 2025	STATE STREET CORP	0.78%	344.6K	2M	71.83K	+26.33%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.93%	409.64K	2.37M	29.06K	+7.64%
Mar 31, 2025	SWISS NATIONAL BANK	0.07%	30.1K	174.28K	30.1K	+100.00%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.27%	118.45K	685.83K	-21.17K	-15.16%
Mar 31, 2025	STONERIDGE INVESTMENT PARTNERS LLC	0.04%	18.48K	107K	18.48K	+100.00%
Mar 31, 2025	SAMSARA BIOCAPITAL, LLC	9.72%	3.15M	18.23M	380.61K	+13.75%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	1.35%	436.56K	2.53M	436.56K	+100.00%
Mar 31, 2025	CITIGROUP INC	0.09%	38.06K	220.34K	23.42K	+160.06%
Mar 31, 2025	TRV GP VI, LLC	13.01%	4.21M	24.39M	1.06M	+33.60%
Mar 31, 2025	BVF INC/IL	13.58%	4.4M	25.45M	1.94M	+79.29%
Mar 31, 2025	TRV GP V, LLC	19.19%	6.22M	35.99M	0	0
Mar 31, 2025	SIO CAPITAL MANAGEMENT, LLC	2.44%	788.67K	4.57M	516.98K	+190.29%
Mar 31, 2025	SIREN, L.L.C.	5.01%	2.2M	12.75M	0	0
Mar 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	7.11%	3.12M	18.08M	533.06K	+20.58%
Mar 31, 2025	LINDBROOK CAPITAL, LLC	0.05%	21K	121.59K	0	0
Mar 31, 2025	CASDIN CAPITAL, LLC	1.71%	553.27K	3.2M	0	0
Mar 31, 2025	VANGUARD GROUP INC	2.26%	995.04K	5.76M	10.01K	+1.02%
Mar 31, 2025	CHECKPOINT CAPITAL L.P.	2.55%	824.88K	4.78M	824.88K	+100.00%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.09%	38.38K	222.2K	283	+0.74%
Mar 31, 2025	JANE STREET GROUP, LLC	0.1%	44K	254.76K	44K	+100.00%
Mar 31, 2025	WOODLINE PARTNERS LP	1.33%	582.59K	3.37M	282.59K	+94.20%
Mar 31, 2025	BLACKROCK, INC.	2.86%	1.26M	7.29M	-418.82K	-24.97%
Mar 31, 2025	AVORO CAPITAL ADVISORS LLC	3.04%	1.34M	7.74M	227.5K	+20.50%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	3.3%	1.45M	8.39M	-224.96K	-13.44%
Mar 31, 2025	DEEP TRACK CAPITAL, LP	5.91%	1.91M	11.08M	0	0
Mar 31, 2025	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0.1%	44.36K	256.86K	42.99K	+3,138.10%
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	2.23%	720.85K	4.17M	720.85K	+100.00%
Mar 31, 2025	RHUMBLINE ADVISERS	0.05%	23.32K	135.01K	3.32K	+16.62%
Mar 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.08%	35K	202.65K	0	0
Mar 31, 2025		0.05%	23.96K	138.73K	23.96K	+100.00%
Mar 31, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	2.32%	751.35K	4.35M	75.94K	+11.24%
Mar 31, 2025	XTX TOPCO LTD	0.09%	37.35K	216.26K	37.35K	+100.00%
Mar 31, 2025	GSA CAPITAL PARTNERS LLP	0.04%	18.3K	106K	18.3K	+100.00%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.04%	18.3K	105.96K	18.3K	+100.00%
Mar 31, 2025	DEUTSCHE BANK AG\	0.04%	15.97K	92.46K	5.55K	+53.26%
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	21.6%	7M	40.51M	0	0
Mar 31, 2025	BARCLAYS PLC	0.05%	22.73K	132K	-6.05K	-21.02%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.05%	22.96K	133K	-495.63K	-95.57%

Insiders

Among the SEPN insiders holding of 3.15% of the stake in company, BHATT ELIZABETH, President and COO, holds the largest shares of 174.21K. LONG DANIEL D., SVP, Drug Discovery, is the second largest SEPN insider with ownership of 92.91K shares. , , stands third with possession of - shares of that stake.

Insiders	Designation	Shares Held
BHATT ELIZABETH	President and COO	174.21K
LONG DANIEL D.	SVP, Drug Discovery	92.91K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Feb 18, 2026	BHATT ELIZABETH	SALE	29.58	1.8K	53.25K	174.21K
Nov 10, 2025	LONG DANIEL D.	SALE	18.06	3.5K	63.22K	92.91K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES5.3K2

NET SHARES-5.3K2

SHARES HELD267.12K2

% NET SHARES-101.98%0%

Frequently Asked Questions

Stock Outstanding Shares

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares7.12

Short Percent Of Float12.31

Shares Outstanding44.59M

Shares Float18.18M

Shares Short3.17M

Short Ratio12.22

12.31%

Short % of Float

7.12%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

3.15% Percentage of Shares held by All Insiders

100.83% Percentage of Shares held by All Institutions

104.11% Percentage of Float held by Institutions

128

Number of Institutions Holding Shares

Institutional Ownership

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	RANGELEY CAPITAL, LLC	0.15%	65.8K	1.83M	-22.2K	-25.23%
Dec 31, 2025	JPMORGAN CHASE & CO	0.15%	68.34K	1.91M	59.6K	+682.26%
Dec 31, 2025	UBS GROUP AG	0.16%	68.82K	1.92M	9.77K	+16.55%
Dec 31, 2025	HIGHVISTA STRATEGIES LLC	0.18%	78.68K	2.19M	78.68K	+100.00%
Dec 31, 2025	FEDERATED HERMES, INC.	0.18%	78.91K	2.2M	78.91K	+100.00%
Dec 31, 2025	MORGAN STANLEY	0.23%	103.99K	2.9M	49.53K	+90.95%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.42%	187.24K	5.22M	337	+0.18%
Dec 31, 2025		0.44%	194.54K	5.42B	194.54K	+100.00%
Dec 31, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.5%	222.7K	6.21M	0	0
Dec 31, 2025	ADVISOR GROUP HOLDINGS, INC.	0.03%	12.69K	353.88K	-170	-1.32%
Dec 31, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	13.28K	370.33K	13.28K	+100.00%
Dec 31, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	13.69K	381.54K	0	0
Dec 31, 2025	SQUAREPOINT OPS LLC	0.03%	14.85K	413.93K	14.85K	+100.00%
Dec 31, 2025	FRANKLIN RESOURCES INC	0.04%	16.85K	469.83K	16.85K	+100.00%
Dec 31, 2025	TUDOR INVESTMENT CORP ET AL	0.04%	18.05K	503.32K	18.05K	+100.00%
Dec 31, 2025	MARSHALL WACE, LLP	0.51%	226.9K	6.33M	226.9K	+100.00%
Dec 31, 2025	CATALIO CAPITAL MANAGEMENT, LP	0.66%	294.36K	8.21M	0	0
Dec 31, 2025	WOODLINE PARTNERS LP	0.87%	385.31K	10.74M	102.73K	+36.35%
Dec 31, 2025	PERCEPTIVE ADVISORS LLC	0.98%	433.16K	12.08M	-108.29K	-20.00%
Dec 31, 2025	CASDIN CAPITAL, LLC	1.25%	553.27K	15.43M	0	0
Dec 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	2.61%	1.16M	32.27M	-18.88K	-1.60%
Dec 31, 2025	AVORO CAPITAL ADVISORS LLC	3.02%	1.34M	37.29M	0	0
Dec 31, 2025	SAMSARA BIOCAPITAL, LLC	7.1%	3.15M	87.8M	0	0
Dec 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	10.85%	4.81M	134.09M	-110.43K	-2.24%
Dec 31, 2025	RHUMBLINE ADVISERS	0.06%	26.42K	736.55M	-1.19K	-4.29%
Dec 31, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.04%	18.55K	398.64K	18.55K	+100.00%
Dec 31, 2025	RA CAPITAL MANAGEMENT, L.P.	15.78%	7M	195.04M	0	0
Dec 31, 2025	BVF INC/IL	3.88%	1.72M	47.98M	-2.3M	-57.15%
Dec 31, 2025	FIRST LIGHT ASSET MANAGEMENT, LLC	1.4%	620.81K	17.31M	620.81K	+100.00%
Dec 31, 2025	VR ADVISER, LLC	1.38%	610.81K	17.03M	0	0
Dec 31, 2025	NORTHERN TRUST CORP	0.35%	154.2K	4.3M	-13.15K	-7.86%
Dec 31, 2025	XTX TOPCO LTD	0.05%	23.32K	650.02K	23.32K	+100.00%
Dec 31, 2025	LOGOS GLOBAL MANAGEMENT LP	0.05%	23.55K	656.52K	-60K	-71.82%
Dec 31, 2025	INVESCO LTD.	0.37%	162.01K	4.52M	-15.06K	-8.50%
Dec 31, 2025	TWO SIGMA ADVISERS, LP	0.06%	25.7K	716.52K	5K	+24.15%
Dec 31, 2025	NUVEEN, LLC	0.06%	25.8K	719.25K	1.84K	+7.67%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.06%	26.53K	739.63K	6.38K	+31.68%
Dec 31, 2025	ACADIAN ASSET MANAGEMENT LLC	0.07%	30.88K	858K	30.88K	+100.00%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	0.08%	37.59K	1.05M	-13.9K	-26.99%
Dec 31, 2025	BARCLAYS PLC	0.09%	38.15K	1.06M	8.05K	+26.73%
Dec 31, 2025	AMERICAN CENTURY COMPANIES INC	0.11%	50.69K	1.41M	25.41K	+100.49%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.12%	55.33K	1.54M	3.7K	+7.17%
Dec 31, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	0.14%	61.37K	1.71M	25.59K	+71.53%
Dec 31, 2025	JANE STREET GROUP, LLC	0.1%	44.07K	1.23M	44.07K	+100.00%
Dec 31, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.86%	383.37K	10.69M	365.11K	+1,999.50%
Dec 31, 2025	GLOBAL RETIREMENT PARTNERS, LLC	0%	1.26K	35.02K	1.26K	+100.00%
Dec 31, 2025	CAITONG INTERNATIONAL ASSET MANAGEMENT CO., LTD	0%	1.9K	53K	1.9K	+100.00%
Dec 31, 2025	COVESTOR LTD	0%	1.94K	54K	-1.68K	-46.38%
Dec 31, 2025	AMERITAS INVESTMENT PARTNERS, INC.	0%	1.94K	54.2K	0	0
Dec 31, 2025	STATE STREET CORP	1.22%	540.03K	15.06M	121.07K	+28.90%
Dec 31, 2025	PRIMECAP MANAGEMENT CO/CA/	1.23%	546.1K	15.23M	546.1K	+100.00%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.29%	572.73K	15.97M	27.03K	+4.95%
Dec 31, 2025	VANGUARD GROUP INC	3.4%	1.51M	42.05M	-10.56K	-0.70%
Dec 31, 2025	BLACKROCK, INC.	4.06%	1.8M	50.22M	341.53K	+23.40%
Dec 31, 2025	SIREN, L.L.C.	4.51%	2M	55.76M	-202.51K	-9.19%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	6.12%	2.72M	75.7M	1.26M	+86.64%
Dec 31, 2025	TRV GP VI, LLC	9.5%	4.21M	117.42M	0	0
Dec 31, 2025	TRV GP V, LLC	14.02%	6.22M	173.29M	0	0
Dec 31, 2025	VIRTUS INVESTMENT ADVISERS, INC.	0.02%	10.46K	291.54K	10.46K	+100.00%
Dec 31, 2025	DYNAMIC TECHNOLOGY LAB PRIVATE LTD	0.02%	10.81K	301K	10.81K	+100.00%
Dec 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.08%	35K	975.8K	0	0
Dec 31, 2025	DEUTSCHE BANK AG\	0.03%	14.88K	414.83K	744	+5.26%
Dec 31, 2025	STRS OHIO	0.03%	14.6K	407.05K	14.6K	+100.00%
Dec 31, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	10.3K	287.05K	10.3K	+100.00%
Dec 31, 2025	BAADER BANK AKTIENGESELLSCHAFT	0.02%	10K	278.8K	10K	+100.00%
Dec 31, 2025	CITIGROUP INC	0.02%	9.56K	266.56K	9.31K	+3,739.76%
Dec 31, 2025	JUMP FINANCIAL, LLC	0.02%	8.4K	234.16K	8.4K	+100.00%
Dec 31, 2025	BANK OF NOVA SCOTIA	0.02%	8.3K	231.4K	8.3K	+100.00%
Dec 31, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.01%	5.6K	156.13K	2.7K	+93.10%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.01%	5.45K	151.92K	1.29K	+31.14%
Dec 31, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.01%	5.18K	144.28K	0	0
Dec 31, 2025	CITADEL ADVISORS LLC	0.17%	75.95K	2.12M	75.95K	+100.00%
Dec 31, 2025	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0%	2.18K	60.67K	2.18K	+100.00%
Dec 31, 2025	LEGAL & GENERAL GROUP PLC	0%	1.95K	54.17K	0	0
Dec 31, 2025	TWO SIGMA INVESTMENTS, LP	0.21%	92.81K	2.59M	475	+0.51%
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.16%	69.2K	1.93M	-3.4K	-4.68%
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	0.24%	107.46K	3M	-276.74K	-72.03%
Dec 31, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.09%	37.87K	1.06M	37.87K	+100.00%
Dec 31, 2025	TREXQUANT INVESTMENT LP	0.1%	44.01K	1.23M	44.01K	+100.00%
Dec 31, 2025	NUMERAI GP LLC	0.1%	45.87K	1.28M	45.87K	+100.00%
Dec 31, 2025	LONGAEVA PARTNERS L.P.	0.11%	49.9K	1.39M	-7.16K	-12.55%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.05%	20.15K	378.97K	5.43K	+36.90%
Sep 30, 2025	BLACKROCK, INC.	3.31%	1.46M	27.46M	69K	+4.96%
Sep 30, 2025	BVF INC/IL	9.09%	4.02M	75.54M	-380.33K	-8.65%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	3.29%	1.45M	27.36M	38.41K	+2.71%
Sep 30, 2025	AVORO CAPITAL ADVISORS LLC	3.03%	1.34M	25.16M	100K	+8.08%
Sep 30, 2025	VR ADVISER, LLC	1.38%	610.81K	11.49M	70.36K	+13.02%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.24%	545.7K	10.27M	57.75K	+11.83%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.87%	384.2K	7.23M	332.26K	+639.64%
Sep 30, 2025	LOGOS GLOBAL MANAGEMENT LP	0.19%	83.55K	1.57M	-25.65K	-23.49%
Sep 30, 2025	WALLEYE CAPITAL LLC	0.18%	80.34K	1.51M	80.34K	+100.00%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.16%	72.6K	1.37M	45K	+163.04%
Sep 30, 2025	MORGAN STANLEY	0.12%	54.46K	1.02M	-30.4K	-35.83%
Sep 30, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.04%	18.26K	343.47K	-57.2K	-75.80%
Sep 30, 2025	TWO SIGMA ADVISERS, LP	0.05%	20.7K	389.37K	20.7K	+100.00%
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	15.84%	7M	131.59M	0	0
Sep 30, 2025	SAMSARA BIOCAPITAL, LLC	7.13%	3.15M	59.24M	0	0
Sep 30, 2025	INVESCO LTD.	0.4%	177.07K	3.33M	165.24K	+1,396.41%
Sep 30, 2025	NORTHERN TRUST CORP	0.38%	167.35K	3.15M	13K	+8.42%
Sep 30, 2025	BARCLAYS PLC	0.07%	30.1K	566.22K	-5.6K	-15.69%
Sep 30, 2025	DEUTSCHE BANK AG\	0.03%	14.14K	265.88K	2.01K	+16.60%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	13.69K	257.42K	0	0
Sep 30, 2025	ADVISOR GROUP HOLDINGS, INC.	0.03%	12.86K	241.95K	12.65K	+5,910.75%
Sep 30, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0.02%	9.79K	184.17K	-1.91K	-16.29%
Sep 30, 2025	JPMORGAN CHASE & CO	0.02%	8.74K	164.32K	-1.37K	-13.51%
Sep 30, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.01%	5.18K	97.34K	1.62K	+45.57%
Sep 30, 2025	TRV GP V, LLC	14.07%	6.22M	116.92M	0	0
Sep 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	11.14%	4.92M	92.54M	239.47K	+5.12%
Sep 30, 2025	TRV GP VI, LLC	9.54%	4.21M	79.22M	0	0
Sep 30, 2025	SIREN, L.L.C.	4.99%	2.2M	41.43M	0	0
Sep 30, 2025	VANGUARD GROUP INC	3.44%	1.52M	28.57M	104.39K	+7.38%
Sep 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	2.66%	1.18M	22.13M	329.26K	+38.86%
Sep 30, 2025	CASDIN CAPITAL, LLC	1.25%	553.27K	10.41M	0	0
Sep 30, 2025	PERCEPTIVE ADVISORS LLC	1.23%	541.45K	10.18M	0	0
Sep 30, 2025	STATE STREET CORP	0.95%	418.96K	7.88M	48.97K	+13.23%
Sep 30, 2025	JANE STREET GROUP, LLC	0.8%	352.4K	6.63M	-95.9K	-21.39%
Sep 30, 2025	CATALIO CAPITAL MANAGEMENT, LP	0.67%	294.36K	5.54M	0	0
Sep 30, 2025	WOODLINE PARTNERS LP	0.64%	282.59K	5.32M	0	0
Sep 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.5%	222.7K	4.19M	0	0
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.21%	92.33K	1.74M	14.69K	+18.92%
Sep 30, 2025	RANGELEY CAPITAL, LLC	0.2%	88K	1.66M	29.4K	+50.16%
Sep 30, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	0.08%	35.78K	672.98K	35.78K	+100.00%
Sep 30, 2025	RHUMBLINE ADVISERS	0.06%	27.6K	519.22K	-968	-3.39%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.06%	25.28K	475.57K	25.28K	+100.00%
Sep 30, 2025	NUVEEN, LLC	0.05%	23.96K	450.71K	-34.01K	-58.67%
Sep 30, 2025	VERITION FUND MANAGEMENT LLC	0.05%	20.13K	378.66K	20.13K	+100.00%
Sep 30, 2025	UBS GROUP AG	0.13%	59.05K	1.11M	-13.29K	-18.37%
Sep 30, 2025	LONGAEVA PARTNERS L.P.	0.13%	57.06K	1.07M	57.06K	+100.00%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.12%	51.63K	971.18K	3.14K	+6.48%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.01%	4.16K	78.16K	1.95K	+88.01%
Sep 30, 2025	COVESTOR LTD	0.01%	3.62K	68K	1.3K	+55.77%
Sep 30, 2025	FMR LLC	0.01%	3.44K	64.67K	953	+38.35%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.01%	2.9K	54.55K	0	0
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0%	1.95K	36.59K	0	0
Sep 30, 2025	AMERITAS INVESTMENT PARTNERS, INC.	0%	1.94K	36.57K	0	0
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0%	1.9K	35.66K	1.9K	+100.00%
Sep 30, 2025	GROUP ONE TRADING, L.P.	0%	1.69K	31.77M	900	+114.07%
Sep 30, 2025	STERLING CAPITAL MANAGEMENT LLC	0%	1.48K	27.75K	898	+155.63%
Sep 30, 2025	SIGNATUREFD, LLC	0%	966	18.17K	0	0
Sep 30, 2025	CWM, LLC	0%	884	17K	12	+1.38%
Sep 30, 2025	GAMMA INVESTING LLC	0%	804	15.12K	227	+39.34%
Sep 30, 2025	AMALGAMATED BANK	0%	634	12K	0	0
Sep 30, 2025	US BANCORP \DE\	0%	265	4.99K	0	0
Sep 30, 2025	VERSANT CAPITAL MANAGEMENT, INC	0%	261	4.91K	261	+100.00%
Sep 30, 2025	CITIGROUP INC	0%	249	4.68K	-6.92K	-96.53%
Sep 30, 2025	PNC FINANCIAL SERVICES GROUP, INC.	0%	198	3.72K	198	+100.00%
Sep 30, 2025	NISA INVESTMENT ADVISORS, LLC	0%	143	2.69K	0	0
Sep 30, 2025	FORTITUDE FAMILY OFFICE, LLC	0%	71	1.34K	0	0
Sep 30, 2025	EVERSOURCE WEALTH ADVISORS, LLC	0%	63	1.19K	41	+186.36%
Sep 30, 2025	SBI SECURITIES CO., LTD.	0%	50	941	0	0
Sep 30, 2025	ROTHSCHILD INVESTMENT LLC	0%	30	564	0	0
Sep 30, 2025	STRS OHIO	0%	0	-	-3.4K	-100.00%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0%	0	-	-12.2K	-100.00%
Sep 30, 2025	GSA CAPITAL PARTNERS LLP	0%	0	-	-23.53K	-100.00%
Sep 30, 2025	SIMPLEX TRADING, LLC	0%	0	-	-23.53K	-100.00%
Sep 30, 2025	QUADRATURE CAPITAL LTD	0%	0	-	-10.13K	-100.00%
Sep 30, 2025	CHECKPOINT CAPITAL L.P.	0.64%	283.16K	5.33M	-303.32K	-51.72%
Sep 30, 2025	SIO CAPITAL MANAGEMENT, LLC	0.43%	189.2K	3.56M	-395.24K	-67.63%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.42%	186.9K	3.52M	32.12K	+20.75%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.12%	51.5K	968.62K	-47.72K	-48.10%
Sep 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.08%	35K	658.35K	0	0
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.06%	27.42K	516K	2.52K	+10.13%
Sep 30, 2025	ALLIANCEBERNSTEIN L.P.	0.05%	22.1K	415.7K	0	0
Jun 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.5%	222.7K	2.35M	119.95K	+116.74%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.1%	487.96K	5.16M	78.32K	+19.12%
Jun 30, 2025	WOODLINE PARTNERS LP	0.64%	282.59K	2.99M	-300K	-51.49%
Jun 30, 2025		0.13%	57.97K	612.75K	34.01K	+141.94%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.35%	154.78K	1.64M	36.33K	+30.67%
Jun 30, 2025	NORTHERN TRUST CORP	0.35%	154.34K	1.63M	-3.7K	-2.34%
Jun 30, 2025	DEEP TRACK CAPITAL, LP	0.28%	121.72K	1.29M	-1.79M	-93.64%
Jun 30, 2025	LOGOS GLOBAL MANAGEMENT LP	0.25%	109.2K	1.15M	-25K	-18.63%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.22%	99.21K	1.05M	87.65K	+758.32%
Jun 30, 2025	TWO SIGMA INVESTMENTS, LP	0.18%	77.64K	820.68K	2.8K	+3.74%
Jun 30, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.17%	75.46K	797.57K	-675.9K	-89.96%
Jun 30, 2025	UBS GROUP AG	0.16%	72.34K	764.58K	-167.6K	-69.85%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.12%	51.94K	549.05K	-384.62K	-88.10%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.11%	48.49K	512.53K	10.11K	+26.35%
Jun 30, 2025	BARCLAYS PLC	0.08%	35.71K	377K	12.97K	+57.07%
Jun 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.08%	35K	369.95K	0	0
Jun 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.07%	28.7K	303.36K	28.7K	+100.00%
Jun 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.05%	24.14K	255.18K	24.14K	+100.00%
Jun 30, 2025	GSA CAPITAL PARTNERS LLP	0.05%	23.53K	249K	5.23K	+28.57%
Jun 30, 2025	SIMPLEX TRADING, LLC	0.05%	23.53K	248K	23.53K	+100.00%
Jun 30, 2025	XTX TOPCO LTD	0.05%	22.33K	236.03K	-15.02K	-40.21%
Jun 30, 2025	TUDOR INVESTMENT CORP ET AL	0.04%	16.76K	177.16K	16.76K	+100.00%
Jun 30, 2025	WELLS FARGO & COMPANY/MN	0.03%	14.72K	155.56K	3.85K	+35.40%
Jun 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	13.69K	144.65K	13.69K	+100.00%
Jun 30, 2025	CONGRESS WEALTH MANAGEMENT LLC / DE /	0.03%	12.59K	133.07K	12.59K	+100.00%
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	15.84%	7M	73.95M	0	0
Jun 30, 2025	TRV GP V, LLC	14.07%	6.22M	65.7M	0	0
Jun 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	10.6%	4.68M	49.47M	1.56M	+49.89%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	3.21%	1.42M	14.97B	-33.09K	-2.28%
Jun 30, 2025	CITADEL ADVISORS LLC	0.23%	100.6K	1.06B	89.1K	+774.78%
Jun 30, 2025	MORGAN STANLEY	0.19%	84.86K	896.97M	-6.18K	-6.79%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.05%	22.1K	233.6M	22.1K	+100.00%
Jun 30, 2025	CATALIO CAPITAL MANAGEMENT, LP	0.67%	294.36K	3.11M	-729.89K	-71.26%
Jun 30, 2025	RANGELEY CAPITAL, LLC	0.13%	58.61K	619.46K	5.66K	+10.68%
Jun 30, 2025	NUVEEN, LLC	0.13%	57.97K	612.75K	34.01K	+141.94%
Jun 30, 2025	BVF INC/IL	9.95%	4.4M	46.47M	0	0
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.06%	24.9K	264K	1.95K	+8.47%
Jun 30, 2025	RHUMBLINE ADVISERS	0.06%	28.57K	302K	5.25K	+22.53%
Jun 30, 2025	JANE STREET GROUP, LLC	1.02%	448.3K	4.74M	404.3K	+918.86%
Jun 30, 2025	AVORO CAPITAL ADVISORS LLC	2.8%	1.24M	13.08M	-100K	-7.48%
Jun 30, 2025	BLACKROCK, INC.	3.15%	1.39M	14.7M	132.49K	+10.53%
Jun 30, 2025	VANGUARD GROUP INC	3.2%	1.41M	14.95M	419.32K	+42.14%
Jun 30, 2025	SIREN, L.L.C.	4.99%	2.2M	23.28M	0	0
Jun 30, 2025	SAMSARA BIOCAPITAL, LLC	7.13%	3.15M	33.29M	0	0
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.06%	27.6K	291.73K	9.3K	+50.82%
Jun 30, 2025	CHECKPOINT CAPITAL L.P.	1.33%	586.47K	6.2M	-238.41K	-28.90%
Jun 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	1.92%	847.23K	8.96M	126.38K	+17.53%
Jun 30, 2025	VR ADVISER, LLC	1.22%	540.45K	5.71M	540.45K	+100.00%
Jun 30, 2025	PERCEPTIVE ADVISORS LLC	1.23%	541.45K	5.72M	541.45K	+100.00%
Jun 30, 2025	CASDIN CAPITAL, LLC	1.25%	553.27K	5.85M	0	0
Jun 30, 2025	SIO CAPITAL MANAGEMENT, LLC	1.32%	584.44K	6.18M	-204.24K	-25.90%
Jun 30, 2025	TRV GP VI, LLC	9.54%	4.21M	44.52M	0	0
Jun 30, 2025	STATE STREET CORP	0.84%	369.99K	3.91M	25.39K	+7.37%
Mar 31, 2025	FMR LLC	0.11%	49.78K	288.22K	-953.18K	-95.04%
Mar 31, 2025	STONEPINE CAPITAL MANAGEMENT, LLC	0.16%	68.08K	394.21K	68.08K	+100.00%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.17%	74.84K	433.33K	74.84K	+100.00%
Mar 31, 2025	MORGAN STANLEY	0.21%	91.04K	527.15K	49.13K	+117.23%
Mar 31, 2025	NORTHERN TRUST CORP	0.36%	158.04K	915.05K	10.26K	+6.95%
Mar 31, 2025	LOGOS GLOBAL MANAGEMENT LP	0.41%	134.2K	777.03K	0	0
Mar 31, 2025	UBS GROUP AG	0.55%	239.93K	1.39M	131.48K	+121.23%
Mar 31, 2025	STATE STREET CORP	0.78%	344.6K	2M	71.83K	+26.33%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.93%	409.64K	2.37M	29.06K	+7.64%
Mar 31, 2025	SWISS NATIONAL BANK	0.07%	30.1K	174.28K	30.1K	+100.00%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.27%	118.45K	685.83K	-21.17K	-15.16%
Mar 31, 2025	STONERIDGE INVESTMENT PARTNERS LLC	0.04%	18.48K	107K	18.48K	+100.00%
Mar 31, 2025	SAMSARA BIOCAPITAL, LLC	9.72%	3.15M	18.23M	380.61K	+13.75%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	1.35%	436.56K	2.53M	436.56K	+100.00%
Mar 31, 2025	CITIGROUP INC	0.09%	38.06K	220.34K	23.42K	+160.06%
Mar 31, 2025	TRV GP VI, LLC	13.01%	4.21M	24.39M	1.06M	+33.60%
Mar 31, 2025	BVF INC/IL	13.58%	4.4M	25.45M	1.94M	+79.29%
Mar 31, 2025	TRV GP V, LLC	19.19%	6.22M	35.99M	0	0
Mar 31, 2025	SIO CAPITAL MANAGEMENT, LLC	2.44%	788.67K	4.57M	516.98K	+190.29%
Mar 31, 2025	SIREN, L.L.C.	5.01%	2.2M	12.75M	0	0
Mar 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	7.11%	3.12M	18.08M	533.06K	+20.58%
Mar 31, 2025	LINDBROOK CAPITAL, LLC	0.05%	21K	121.59K	0	0
Mar 31, 2025	CASDIN CAPITAL, LLC	1.71%	553.27K	3.2M	0	0
Mar 31, 2025	VANGUARD GROUP INC	2.26%	995.04K	5.76M	10.01K	+1.02%
Mar 31, 2025	CHECKPOINT CAPITAL L.P.	2.55%	824.88K	4.78M	824.88K	+100.00%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.09%	38.38K	222.2K	283	+0.74%
Mar 31, 2025	JANE STREET GROUP, LLC	0.1%	44K	254.76K	44K	+100.00%
Mar 31, 2025	WOODLINE PARTNERS LP	1.33%	582.59K	3.37M	282.59K	+94.20%
Mar 31, 2025	BLACKROCK, INC.	2.86%	1.26M	7.29M	-418.82K	-24.97%
Mar 31, 2025	AVORO CAPITAL ADVISORS LLC	3.04%	1.34M	7.74M	227.5K	+20.50%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	3.3%	1.45M	8.39M	-224.96K	-13.44%
Mar 31, 2025	DEEP TRACK CAPITAL, LP	5.91%	1.91M	11.08M	0	0
Mar 31, 2025	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0.1%	44.36K	256.86K	42.99K	+3,138.10%
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	2.23%	720.85K	4.17M	720.85K	+100.00%
Mar 31, 2025	RHUMBLINE ADVISERS	0.05%	23.32K	135.01K	3.32K	+16.62%
Mar 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.08%	35K	202.65K	0	0
Mar 31, 2025		0.05%	23.96K	138.73K	23.96K	+100.00%
Mar 31, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	2.32%	751.35K	4.35M	75.94K	+11.24%
Mar 31, 2025	XTX TOPCO LTD	0.09%	37.35K	216.26K	37.35K	+100.00%
Mar 31, 2025	GSA CAPITAL PARTNERS LLP	0.04%	18.3K	106K	18.3K	+100.00%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.04%	18.3K	105.96K	18.3K	+100.00%
Mar 31, 2025	DEUTSCHE BANK AG\	0.04%	15.97K	92.46K	5.55K	+53.26%
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	21.6%	7M	40.51M	0	0
Mar 31, 2025	BARCLAYS PLC	0.05%	22.73K	132K	-6.05K	-21.02%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.05%	22.96K	133K	-495.63K	-95.57%

Insiders

Insiders	Designation	Shares Held
BHATT ELIZABETH	President and COO	174.21K
LONG DANIEL D.	SVP, Drug Discovery	92.91K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Feb 18, 2026	BHATT ELIZABETH	SALE	29.58	1.8K	53.25K	174.21K
Nov 10, 2025	LONG DANIEL D.	SALE	18.06	3.5K	63.22K	92.91K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES5.3K2

NET SHARES-5.3K2

SHARES HELD267.12K2

% NET SHARES-101.98%0%

SEPN Stock Ownership Breakdown

Septerna

Stock Outstanding Shares

Market Insider

Institutional Ownership

Insiders

Buying/Selling by Insiders

Insider Transaction Summary (6 Months)

Frequently Asked Questions

Stock Outstanding Shares

Market Insider

Institutional Ownership

Insiders

Buying/Selling by Insiders

Insider Transaction Summary (6 Months)

Frequently Asked Questions