How many institutions own SEPN stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own SEPN shares is 226, representing 98.94% of the company's common stock.

Who are the major shareholders selling Septerna Inc stock?

VIRTUS INVESTMENT ADVISERS, INC., in the last quarter, reduced its stake in SEPN by -15.09% restricting it's holding to 9.1 thousand shares of worth nearly $304.83K. WINTON GROUP LTD also lessened -18.77% of the SEPN shares from its portfolio, reducing its holding to 7.18 thousand shares of worth $240.53K. UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH also shunned SEPN shares holding by -0.58% last quarter which brought its holding to 222.7 thousand shares worth $7.46M.

Investors who are buying SEPN stock?

As per its latest 13F filing, DIADEMA PARTNERS LP increased its stake in SEPN by 100% in the last quarter. The institutional holder raised its holding to 59.7 thousand shares having worth more than $2.00M. CHARLES SCHWAB INVESTMENT MANAGEMENT INC also added 3.01% more shares of SEPN to its portfolio, raising its holding to 187.04 thousand shares of worth $6.26M. LONGAEVA PARTNERS L.P. also increased its SEPN shares holding by 299.87% which brought its holding to 298.17 thousand shares worth $9.99M.

SEPN's major insiders: who are they?

The insider with the most stakes in SEPN is Third Rock Ventures V, L.P. , 10 percent owner at the company. Additionally, SEPN stock is highly held by RA CAPITAL MANAGEMENT, L.P. and President and COO Bhatt Elizabeth among others.

Did an insider recently sell SEPN stock?

Company executives, directors, and other insiders own 3.07% percent of Septerna Inc's stock. Within the last six months, there have been 13 transaction(s) in which SEPN insiders have sold stock, totaling 812.98K shares. Insiders that have sold shares include LONG DANIEL D., RA CAPITAL MANAGEMENT, L.P., and THIRD ROCK VENTURES V, L.P..

Which insider recently purchased SEPN stock?

There have been 0 transaction(s) during the past 6-months in which Septerna Inc insiders have bought stock, totalling 0 shares

How much of SEPN does insiders own?

Around 7.71M Septerna Inc shares are held by insiders, which represents about 3.07% of SEPN stock.

Who is the insider with the largest stake?

SEPN 10 percent owner, Third Rock Ventures V, L.P. holds the largest portfolio of the company's shares. SEPN shares owned by Third total nearly 6.07 million.

Which institution holds the most shares in SEPN?

VIRTUS INVESTMENT ADVISERS, INC. is the largest institutional owner in SEPN which holds 9.1 thousand shares worth $304.83K or 0.02% of the total SEPN shares outstanding followed by SOLEUS CAPITAL MANAGEMENT, L.P. with ownership of 275 thousand shares representing 0.61% of the SEPN ownership. DIADEMA PARTNERS LP is the third largest stakeholder with 59.7 thousand shares or 0.13% of the ownership worth more than $2.00M.

Is Septerna Inc stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the SEPN is concerned, it is a stock which is optionable.

Is there a short position on SEPN's shares?

Number of SEPN shares short is 3.35M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding SEPN shares are there?

As of today, 45.08M shares of SEPN are outstanding.

Is there many float in SEPN stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, SEPN has 23.17M shares in float.

SEPN short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for SEPN is 5.73.

Septerna (SEPN) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares7.43

Short Percent Of Float14.68

Shares Outstanding45.08M

Shares Float23.17M

Shares Short3.35M

Short Ratio5.73

14.68%

Short % of Float

7.43%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

3.07% Percentage of Shares held by All Insiders

98.94% Percentage of Shares held by All Institutions

102.07% Percentage of Float held by Institutions

226

Number of Institutions Holding Shares

Institutional Ownership

About 98.94% of SEPN shares are held by financial institutions. VIRTUS INVESTMENT ADVISERS, INC. is the top corporate investor, holding 9.1K shares valued at $304.83K. A 0.02% stake in Septerna Inc is owned by the company. SOLEUS CAPITAL MANAGEMENT, L.P. owns 275K shares valued at $9.21M, which translates its holding of 0.61% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Jun 30, 2026	VIRTUS INVESTMENT ADVISERS, INC.	0.02%	9.1K	304.83K	-1.62K	-15.09%
Jun 30, 2026	SOLEUS CAPITAL MANAGEMENT, L.P.	0.61%	275K	9.21M	0	0
Jun 30, 2026	DIADEMA PARTNERS LP	0.13%	59.7K	2M	59.7K	+100.00%
Jun 30, 2026	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.42%	187.04K	6.26M	5.46K	+3.01%
Jun 30, 2026	LONGAEVA PARTNERS L.P.	0.66%	298.17K	9.99M	223.6K	+299.87%
Jun 30, 2026	BALYASNY ASSET MANAGEMENT L.P.	0.78%	350.44K	11.74M	113.76K	+48.07%
Jun 30, 2026	ALGERT GLOBAL LLC	0.88%	397.49K	13.31M	376.45K	+1,789.65%
Jun 30, 2026	CASDIN CAPITAL, LLC	1.23%	553.27K	18.53M	0	0
Jun 30, 2026	LOOMIS SAYLES & CO L P	1.39%	624.75K	20.92M	624.75K	+100.00%
Jun 30, 2026	STATE STREET CORP	1.45%	652.63K	21.86M	21.18K	+3.35%
Jun 30, 2026	GEODE CAPITAL MANAGEMENT, LLC	1.51%	679.16K	22.75M	34.02K	+5.27%
Jun 30, 2026	WINTON GROUP LTD	0.02%	7.18K	240.53K	-1.66K	-18.77%
Jun 30, 2026	OCCUDO QUANTITATIVE STRATEGIES LP	0.02%	7.19K	240.83K	7.19K	+100.00%
Jun 30, 2026	CAPTION MANAGEMENT, LLC	0.44%	200K	6.7M	200K	+100.00%
Jun 30, 2026	NORTHERN TRUST CORP	0.45%	201.13K	6.74M	36.6K	+22.25%
Jun 30, 2026	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.49%	222.7K	7.46M	-1.29K	-0.58%
Jun 30, 2026	DIMENSIONAL FUND ADVISORS LP	0.17%	75.31K	2.52M	75.31K	+100.00%
Jun 30, 2026	QUANTINNO CAPITAL MANAGEMENT LP	0.02%	7.33K	245.48K	7.33K	+100.00%
Jun 30, 2026	VANGUARD ASSET MANAGEMENT, LTD	0.02%	7.42K	248.5K	0	0
Jun 30, 2026	CREATIVE PLANNING	0.02%	7.64K	255.73K	7.64K	+100.00%
Jun 30, 2026	FIRST TRUST ADVISORS LP	0.02%	7.74K	259.18K	7.74K	+100.00%
Jun 30, 2026	NEW YORK STATE COMMON RETIREMENT FUND	0.02%	8.5K	284.67K	2.9K	+51.79%
Jun 30, 2026	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.02%	9.98K	334.3K	-400	-3.85%
Jun 30, 2026	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	10.77K	360.82K	-1.17K	-9.81%
Jun 30, 2026	VANGUARD GLOBAL ADVISERS, LLC	0.04%	16.25K	544.11K	0	0
Jun 30, 2026	STATE OF WYOMING	0.04%	16.38K	548.53K	16.38K	+100.00%
Jun 30, 2026	LOS ANGELES CAPITAL MANAGEMENT LLC	0.04%	16.6K	555.83K	2.38K	+16.77%
Jun 30, 2026	BNP PARIBAS ARBITRAGE, SNC	0.04%	16.95K	567.52K	11.59K	+216.10%
Jun 30, 2026	CITIGROUP INC	0.04%	17.81K	596.39K	8.61K	+93.67%
Jun 30, 2026	FRANKLIN RESOURCES INC	0.04%	18.61K	623.15K	18.61K	+100.00%
Jun 30, 2026	SWISS NATIONAL BANK	0.04%	19.8K	663.1K	-2.3K	-10.41%
Jun 30, 2026	JUMP FINANCIAL, LLC	0.05%	20.2K	676.5K	-32.81K	-61.89%
Jun 30, 2026	ACADIAN ASSET MANAGEMENT LLC	0.05%	21K	701K	-9.98K	-32.22%
Jun 30, 2026	STRS OHIO	0.05%	21K	703.29K	3.8K	+22.09%
Jun 30, 2026	DEUTSCHE BANK AG\	0.05%	21.87K	732.53K	5.03K	+29.86%
Jun 30, 2026	FOX RUN MANAGEMENT, L.L.C.	0.05%	22.04K	738.05K	22.04K	+100.00%
Jun 30, 2026	FMR LLC	0.05%	23.24K	778.31K	-206	-0.88%
Jun 30, 2026	RHUMBLINE ADVISERS	0.06%	27.64K	925.52K	1.03K	+3.88%
Jun 30, 2026	RUSSELL INVESTMENTS GROUP, LTD.	0.09%	40.21K	1.35M	28.69K	+249.19%
Jun 30, 2026	RENAISSANCE TECHNOLOGIES LLC	0.09%	41.42K	1.39M	3.72K	+9.86%
Jun 30, 2026	NUVEEN, LLC	0.11%	48.23K	1.62M	19.05K	+65.30%
Jun 30, 2026	BANK OF NEW YORK MELLON CORP	0.13%	56.18K	1.88M	-2.53K	-4.31%
Jun 30, 2026		0.43%	194.54K	6.52M	0	0
Jun 30, 2026	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.58%	262K	8.77M	189K	+258.90%
Jun 30, 2026	DRIEHAUS CAPITAL MANAGEMENT LLC	9.84%	4.43M	148.46M	37.49K	+0.85%
Jun 30, 2026	RA CAPITAL MANAGEMENT, L.P.	15.53%	7M	234.29M	0	0
Jun 30, 2026	TWO SIGMA INVESTMENTS, LP	0.49%	220.89K	7.4M	145.52K	+193.08%
Jun 30, 2026	FIRST LIGHT ASSET MANAGEMENT, LLC	2.14%	963.26K	32.26M	230.4K	+31.44%
Jun 30, 2026	PRIMECAP MANAGEMENT CO/CA/	2.59%	1.17M	39.1M	118.55K	+11.30%
Jun 30, 2026	VANGUARD CAPITAL MANAGEMENT LLC	2.71%	1.22M	40.91M	24.71K	+2.06%
Jun 30, 2026	AVORO CAPITAL ADVISORS LLC	2.97%	1.34M	44.79M	0	0
Jun 30, 2026	SIREN, L.L.C.	4.22%	1.9M	63.63M	-100K	-5.00%
Jun 30, 2026	BLACKROCK, INC.	4.29%	1.93M	64.71M	109.91K	+6.03%
Jun 30, 2026	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	0.17%	74.65K	2.5M	74.65K	+100.00%
Jun 30, 2026	GOLDMAN SACHS GROUP INC	6.8%	3.06M	102.57M	156.34K	+5.38%
Jun 30, 2026	SAMSARA BIOCAPITAL, LLC	6.99%	3.15M	105.46M	0	0
Jun 30, 2026	LAZARD ASSET MANAGEMENT LLC	0.17%	75.43K	2.53M	75.43K	+100.00%
Jun 30, 2026	CITADEL ADVISORS LLC	0.18%	81.8K	2.74M	81.8K	+100.00%
Jun 30, 2026	JANE STREET GROUP, LLC	0.13%	57.2K	1.92M	57.2K	+100.00%
Jun 30, 2026	HUSSMAN STRATEGIC ADVISORS, INC.	0.14%	63K	2.11M	-42K	-40.00%
Jun 30, 2026	UBS GROUP AG	0.2%	89.87K	3.01M	-27.11K	-23.17%
Jun 30, 2026	TUDOR INVESTMENT CORP ET AL	0.22%	100K	3.35M	100K	+100.00%
Jun 30, 2026	MORGAN STANLEY	0.3%	134.38K	4.5M	23.85K	+21.58%
Jun 30, 2026	VANGUARD FIDUCIARY TRUST CO	0.37%	165.66K	5.55M	11.17K	+7.23%
Jun 30, 2026	VANGUARD PORTFOLIO MANAGEMENT LLC	0.51%	230.18K	7.71M	35.14K	+18.02%
Jun 30, 2026	CATALIO CAPITAL MANAGEMENT, LP	1.19%	536.15K	17.96M	241.79K	+82.14%
Jun 30, 2026	ADAR1 CAPITAL MANAGEMENT, LLC	2.09%	940.75K	31.51M	-149.07K	-13.68%
Jun 30, 2026	JUPITER TOPCO LLC	2.9%	1.31M	43.72M	1.31M	+100.00%
Jun 30, 2026	TRV GP VI, LLC	9.35%	4.21M	141.05M	0	0
Jun 30, 2026	TRV GP V, LLC	13.8%	6.22M	208.16M	0	0
Jun 30, 2026	AMERICAN CENTURY COMPANIES INC	0.14%	60.97K	2.04M	-317	-0.52%
Jun 30, 2026	JACOBS LEVY EQUITY MANAGEMENT, INC	0.15%	68.18K	2.28M	39.74K	+139.77%
Jun 30, 2026	JPMORGAN CHASE & CO	0.19%	85.3K	2.96M	627	+0.74%
Jun 30, 2026	FEDERATED HERMES, INC.	0.19%	86.75K	2.91M	-2.55K	-2.85%
Jun 30, 2026	WOODLINE PARTNERS LP	0.41%	185.54K	6.21M	185.54K	+100.00%
Jun 30, 2026	SIXTH STREET PARTNERS MANAGEMENT COMPANY, L.P.	0.42%	187.04K	6.26M	187.04K	+100.00%
Jun 30, 2026	KALEHUA CAPITAL MANAGEMENT LLC	0.43%	194.54K	6.52M	0	0
Mar 31, 2026	AMERICAN CENTURY COMPANIES INC	0.14%	61.29K	1.47M	10.6K	+20.91%
Mar 31, 2026	LONGAEVA PARTNERS L.P.	0.17%	74.57K	1.79M	24.67K	+49.43%
Mar 31, 2026	TWO SIGMA INVESTMENTS, LP	0.17%	75.37K	1.81M	-17.44K	-18.79%
Mar 31, 2026	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.16%	73K	1.75M	3.8K	+5.49%
Mar 31, 2026	STATE STREET CORP	1.41%	631.45K	15.17M	91.42K	+16.93%
Mar 31, 2026	DRIEHAUS CAPITAL MANAGEMENT LLC	9.82%	4.4M	105.63M	-413.9K	-8.61%
Mar 31, 2026	RA CAPITAL MANAGEMENT, L.P.	15.63%	7M	168.11M	0	0
Mar 31, 2026	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.5%	224K	5.38M	1.29K	+0.58%
Mar 31, 2026	SOFINNOVA INVESTMENTS, INC.	0.11%	47.51K	1.14M	47.51K	+100.00%
Mar 31, 2026	BLACKROCK, INC.	4.07%	1.82M	43.79M	20.85K	+1.16%
Mar 31, 2026	GOLDMAN SACHS GROUP INC	6.49%	2.91M	69.84M	191.3K	+7.05%
Mar 31, 2026	MILLENNIUM MANAGEMENT LLC	0.28%	124.1K	2.98M	16.64K	+15.48%
Mar 31, 2026	SIREN, L.L.C.	4.47%	2M	48.06M	0	0
Mar 31, 2026	VANGUARD CAPITAL MANAGEMENT LLC	2.67%	1.2M	28.76M	1.2M	+100.00%
Mar 31, 2026	SAMSARA BIOCAPITAL, LLC	7.04%	3.15M	75.67M	0	0
Mar 31, 2026	NUVEEN, LLC	0.07%	29.18K	701.1K	3.38K	+13.09%
Mar 31, 2026	XTX TOPCO LTD	0.08%	36.72K	882.45K	13.41K	+57.51%
Mar 31, 2026	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.41%	181.58K	4.36M	-5.66K	-3.02%
Mar 31, 2026		0.43%	194.54K	4.67M	0	0
Mar 31, 2026	TRV GP VI, LLC	9.41%	4.21M	101.21M	0	0
Mar 31, 2026	VANGUARD FIDUCIARY TRUST CO	0.35%	154.48K	3.71M	154.48K	+100.00%
Mar 31, 2026	NORTHERN TRUST CORP	0.37%	164.53K	3.95M	10.33K	+6.70%
Mar 31, 2026	TREXQUANT INVESTMENT LP	0.08%	35.3K	848.28K	-8.7K	-19.78%
Mar 31, 2026	UBS GROUP AG	0.26%	116.98K	2.81M	48.16K	+69.99%
Mar 31, 2026	ACADIAN ASSET MANAGEMENT LLC	0.07%	30.98K	741K	101	+0.33%
Mar 31, 2026	RANGELEY CAPITAL, LLC	0.09%	39.8K	956.39K	-26K	-39.51%
Mar 31, 2026	MARSHALL WACE, LLP	0.09%	39.84K	957.35K	-187.06K	-82.44%
Mar 31, 2026	JUMP FINANCIAL, LLC	0.12%	53.01K	1.27M	44.61K	+531.16%
Mar 31, 2026	INVESCO LTD.	0.19%	82.87K	1.99M	-79.15K	-48.85%
Mar 31, 2026	ADAR1 CAPITAL MANAGEMENT, LLC	2.43%	1.09M	26.19M	-67.79K	-5.86%
Mar 31, 2026	AVORO CAPITAL ADVISORS LLC	2.99%	1.34M	32.14M	0	0
Mar 31, 2026	BVF INC/IL	3.02%	1.35M	32.52M	-367.53K	-21.36%
Mar 31, 2026	JPMORGAN CHASE & CO	0.19%	84.67K	1.97M	16.34K	+23.90%
Mar 31, 2026	FEDERATED HERMES, INC.	0.2%	89.3K	2.15M	10.4K	+13.18%
Mar 31, 2026	CHECKPOINT CAPITAL L.P.	0.22%	100.3K	2.41M	100.3K	+100.00%
Mar 31, 2026	HUSSMAN STRATEGIC ADVISORS, INC.	0.23%	105K	2.52M	105K	+100.00%
Mar 31, 2026	ALYESKA INVESTMENT GROUP, L.P.	0.08%	35K	841.05K	0	0
Mar 31, 2026	BANK OF NEW YORK MELLON CORP	0.13%	58.71K	1.41M	3.38K	+6.10%
Mar 31, 2026	MORGAN STANLEY	0.25%	110.53K	2.66M	6.55K	+6.29%
Mar 31, 2026	BALYASNY ASSET MANAGEMENT L.P.	0.53%	236.68K	5.69M	233.11K	+6,527.81%
Mar 31, 2026	RENAISSANCE TECHNOLOGIES LLC	0.08%	37.7K	905.93K	37.7K	+100.00%
Mar 31, 2026	SOLEUS CAPITAL MANAGEMENT, L.P.	0.61%	275K	6.61M	-108.37K	-28.27%
Mar 31, 2026	CATALIO CAPITAL MANAGEMENT, LP	0.66%	294.36K	7.07M	0	0
Mar 31, 2026	VR ADVISER, LLC	1.13%	506.06K	12.16M	-104.75K	-17.15%
Mar 31, 2026	CASDIN CAPITAL, LLC	1.24%	553.27K	13.3M	0	0
Mar 31, 2026	GEODE CAPITAL MANAGEMENT, LLC	1.44%	645.15K	15.51M	72.41K	+12.64%
Mar 31, 2026	FIRST LIGHT ASSET MANAGEMENT, LLC	1.64%	732.86K	17.61M	112.05K	+18.05%
Mar 31, 2026	JANUS HENDERSON GROUP PLC	1.99%	890.75K	21.33M	890.75K	+100.00%
Mar 31, 2026	PRIMECAP MANAGEMENT CO/CA/	2.34%	1.05M	25.2M	502.73K	+92.06%
Mar 31, 2026	EVERSOURCE WEALTH ADVISORS, LLC	0%	1.17K	45.16K	1.11K	+1,753.97%
Mar 31, 2026	AMERITAS INVESTMENT PARTNERS, INC.	0%	1.94K	46.71K	0	0
Mar 31, 2026	COVESTOR LTD	0.01%	2.26K	54K	319	+16.43%
Mar 31, 2026	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.01%	2.34K	56.11K	159	+7.31%
Mar 31, 2026	KLP KAPITALFORVALTNING AS	0.01%	2.5K	60.08K	2.5K	+100.00%
Mar 31, 2026	PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO	0.01%	3.37K	81.08K	-7.22K	-68.15%
Mar 31, 2026	VANGUARD INVESTMENTS AUSTRALIA, LTD.	0.01%	3.9K	93.6K	3.9K	+100.00%
Mar 31, 2026	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.01%	5.18K	124.36K	0	0
Mar 31, 2026	BNP PARIBAS ARBITRAGE, SNC	0.01%	5.36K	128.83K	-88	-1.62%
Mar 31, 2026	NEW YORK STATE COMMON RETIREMENT FUND	0.01%	5.6K	134.57K	0	0
Mar 31, 2026	LEGAL & GENERAL GROUP PLC	0.01%	5.74K	137.81K	3.79K	+194.86%
Mar 31, 2026	VANGUARD ASSET MANAGEMENT, LTD	0.02%	7.42K	178.3K	7.42K	+100.00%
Mar 31, 2026	WINTON GROUP LTD	0.02%	8.84K	212.47K	8.84K	+100.00%
Mar 31, 2026	CITIGROUP INC	0.02%	9.2K	220.96K	-366	-3.83%
Mar 31, 2026	WELLS FARGO & COMPANY/MN	0.02%	9.87K	237.15K	-16.66K	-62.80%
Mar 31, 2026	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.02%	10.38K	249.48K	10.38K	+100.00%
Mar 31, 2026	VIRTUS INVESTMENT ADVISERS, INC.	0.02%	10.72K	257.58K	262	+2.51%
Mar 31, 2026	RUSSELL INVESTMENTS GROUP, LTD.	0.03%	11.52K	276.71K	-3.8K	-24.79%
Mar 31, 2026	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.03%	11.95K	287.06K	1.65K	+16.03%
Mar 31, 2026	ENTRYPOINT CAPITAL, LLC	0.03%	12.78K	307.01K	12.78K	+100.00%
Mar 31, 2026	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	13.69K	328.85K	0	0
Mar 31, 2026	LOS ANGELES CAPITAL MANAGEMENT LLC	0.03%	14.21K	341.56K	-4.34K	-23.37%
Mar 31, 2026	VANGUARD GLOBAL ADVISERS, LLC	0.04%	16.25K	390.42K	16.25K	+100.00%
Mar 31, 2026	DEUTSCHE BANK AG\	0.04%	16.84K	404.74K	1.96K	+13.20%
Mar 31, 2026	STRS OHIO	0.04%	17.2K	413.32K	2.6K	+17.81%
Mar 31, 2026	ALGERT GLOBAL LLC	0.05%	21.04K	505K	-13.91K	-39.80%
Mar 31, 2026	SWISS NATIONAL BANK	0.05%	22.1K	531.06K	22.1K	+100.00%
Mar 31, 2026	Y-INTERCEPT (HONG KONG) LTD	0.06%	25.77K	619.25K	25.77K	+100.00%
Mar 31, 2026	RHUMBLINE ADVISERS	0.06%	26.6K	639.29K	185	+0.70%
Mar 31, 2026	TRV GP V, LLC	13.89%	6.22M	149.36M	0	0
Dec 31, 2025	DYNAMIC TECHNOLOGY LAB PRIVATE LTD	0.02%	10.81K	301K	10.81K	+100.00%
Dec 31, 2025	RA CAPITAL MANAGEMENT, L.P.	15.78%	7M	195.04M	0	0
Dec 31, 2025	VR ADVISER, LLC	1.38%	610.81K	17.03M	0	0
Dec 31, 2025	NORTHERN TRUST CORP	0.35%	154.2K	4.3M	-13.15K	-7.86%
Dec 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.08%	35K	975.8K	0	0
Dec 31, 2025	DEUTSCHE BANK AG\	0.03%	14.88K	414.83K	744	+5.26%
Dec 31, 2025	STRS OHIO	0.03%	14.6K	407.05K	14.6K	+100.00%
Dec 31, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	10.3K	287.05K	10.3K	+100.00%
Dec 31, 2025	BAADER BANK AKTIENGESELLSCHAFT	0.02%	10K	278.8K	10K	+100.00%
Dec 31, 2025	CITIGROUP INC	0.02%	9.56K	266.56K	9.31K	+3,739.76%
Dec 31, 2025	JUMP FINANCIAL, LLC	0.02%	8.4K	234.16K	8.4K	+100.00%
Dec 31, 2025	BANK OF NOVA SCOTIA	0.02%	8.3K	231.4K	8.3K	+100.00%
Dec 31, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.01%	5.6K	156.13K	2.7K	+93.10%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.01%	5.45K	151.92K	1.29K	+31.14%
Dec 31, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.01%	5.18K	144.28K	0	0
Dec 31, 2025	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0%	2.18K	60.67K	2.18K	+100.00%
Dec 31, 2025	LEGAL & GENERAL GROUP PLC	0%	1.95K	54.17K	0	0
Dec 31, 2025	BVF INC/IL	3.88%	1.72M	47.98M	-2.3M	-57.15%
Dec 31, 2025	FIRST LIGHT ASSET MANAGEMENT, LLC	1.4%	620.81K	17.31M	620.81K	+100.00%
Dec 31, 2025	RHUMBLINE ADVISERS	0.06%	26.42K	736.55M	-1.19K	-4.29%
Dec 31, 2025	BLACKROCK, INC.	4.06%	1.8M	50.22M	341.53K	+23.40%
Dec 31, 2025	VANGUARD GROUP INC	3.4%	1.51M	42.05M	-10.56K	-0.70%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.29%	572.73K	15.97M	27.03K	+4.95%
Dec 31, 2025	PRIMECAP MANAGEMENT CO/CA/	1.23%	546.1K	15.23M	546.1K	+100.00%
Dec 31, 2025	STATE STREET CORP	1.22%	540.03K	15.06M	121.07K	+28.90%
Dec 31, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.86%	383.37K	10.69M	365.11K	+1,999.50%
Dec 31, 2025		0.44%	194.54K	5.42M	194.54K	+100.00%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.42%	187.24K	5.22M	337	+0.18%
Dec 31, 2025	INVESCO LTD.	0.37%	162.01K	4.52M	-15.06K	-8.50%
Dec 31, 2025	AMERICAN CENTURY COMPANIES INC	0.11%	50.69K	1.41M	25.41K	+100.49%
Dec 31, 2025	JANE STREET GROUP, LLC	0.1%	44.07K	1.23M	44.07K	+100.00%
Dec 31, 2025	BARCLAYS PLC	0.09%	38.15K	1.06M	8.05K	+26.73%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	0.08%	37.59K	1.05M	-13.9K	-26.99%
Dec 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	10.85%	4.81M	134.09M	-110.43K	-2.24%
Dec 31, 2025	SAMSARA BIOCAPITAL, LLC	7.1%	3.15M	87.8M	0	0
Dec 31, 2025	AVORO CAPITAL ADVISORS LLC	3.02%	1.34M	37.29M	0	0
Dec 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	2.61%	1.16M	32.27M	-18.88K	-1.60%
Dec 31, 2025	CASDIN CAPITAL, LLC	1.25%	553.27K	15.43M	0	0
Dec 31, 2025	PERCEPTIVE ADVISORS LLC	0.98%	433.16K	12.08M	-108.29K	-20.00%
Dec 31, 2025	WOODLINE PARTNERS LP	0.87%	385.31K	10.74M	102.73K	+36.35%
Dec 31, 2025	CATALIO CAPITAL MANAGEMENT, LP	0.66%	294.36K	8.21M	0	0
Dec 31, 2025	MORGAN STANLEY	0.23%	103.99K	2.9M	49.53K	+90.95%
Dec 31, 2025	FEDERATED HERMES, INC.	0.18%	78.91K	2.2M	78.91K	+100.00%
Dec 31, 2025	HIGHVISTA STRATEGIES LLC	0.18%	78.68K	2.19M	78.68K	+100.00%
Dec 31, 2025	UBS GROUP AG	0.16%	68.82K	1.92M	9.77K	+16.55%
Dec 31, 2025	JPMORGAN CHASE & CO	0.15%	68.34K	1.91M	59.6K	+682.26%
Dec 31, 2025	RANGELEY CAPITAL, LLC	0.15%	65.8K	1.83M	-22.2K	-25.23%
Dec 31, 2025	LONGAEVA PARTNERS L.P.	0.11%	49.9K	1.39M	-7.16K	-12.55%
Dec 31, 2025	NUMERAI GP LLC	0.1%	45.87K	1.28M	45.87K	+100.00%
Dec 31, 2025	TREXQUANT INVESTMENT LP	0.1%	44.01K	1.23M	44.01K	+100.00%
Dec 31, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.09%	37.87K	1.06M	37.87K	+100.00%
Dec 31, 2025	MARSHALL WACE, LLP	0.51%	226.9K	6.33M	226.9K	+100.00%
Dec 31, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.5%	222.7K	6.21M	0	0
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	0.24%	107.46K	3M	-276.74K	-72.03%
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.16%	69.2K	1.93M	-3.4K	-4.68%
Dec 31, 2025	TWO SIGMA INVESTMENTS, LP	0.21%	92.81K	2.59M	475	+0.51%
Dec 31, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	0.14%	61.37K	1.71M	25.59K	+71.53%
Dec 31, 2025	ACADIAN ASSET MANAGEMENT LLC	0.07%	30.88K	858K	30.88K	+100.00%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.06%	26.53K	739.63K	6.38K	+31.68%
Dec 31, 2025	NUVEEN, LLC	0.06%	25.8K	719.25K	1.84K	+7.67%
Dec 31, 2025	TWO SIGMA ADVISERS, LP	0.06%	25.7K	716.52K	5K	+24.15%
Dec 31, 2025	LOGOS GLOBAL MANAGEMENT LP	0.05%	23.55K	656.52K	-60K	-71.82%
Dec 31, 2025	XTX TOPCO LTD	0.05%	23.32K	650.02K	23.32K	+100.00%
Dec 31, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.04%	18.55K	398.64K	18.55K	+100.00%
Dec 31, 2025	TUDOR INVESTMENT CORP ET AL	0.04%	18.05K	503.32K	18.05K	+100.00%
Dec 31, 2025	FRANKLIN RESOURCES INC	0.04%	16.85K	469.83K	16.85K	+100.00%
Dec 31, 2025	SQUAREPOINT OPS LLC	0.03%	14.85K	413.93K	14.85K	+100.00%
Dec 31, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	13.69K	381.54K	0	0
Dec 31, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	13.28K	370.33K	13.28K	+100.00%
Dec 31, 2025	ADVISOR GROUP HOLDINGS, INC.	0.03%	12.69K	353.88K	-170	-1.32%
Dec 31, 2025	CITADEL ADVISORS LLC	0.17%	75.95K	2.12M	75.95K	+100.00%
Dec 31, 2025	VIRTUS INVESTMENT ADVISERS, INC.	0.02%	10.46K	291.54K	10.46K	+100.00%
Dec 31, 2025	TRV GP V, LLC	14.02%	6.22M	173.29M	0	0
Dec 31, 2025	TRV GP VI, LLC	9.5%	4.21M	117.42M	0	0
Dec 31, 2025	GOLDMAN SACHS GROUP INC	6.12%	2.72M	75.7M	1.26M	+86.64%
Dec 31, 2025	AMERITAS INVESTMENT PARTNERS, INC.	0%	1.94K	54.2K	0	0
Dec 31, 2025	COVESTOR LTD	0%	1.94K	54K	-1.68K	-46.38%
Dec 31, 2025	CAITONG INTERNATIONAL ASSET MANAGEMENT CO., LTD	0%	1.9K	53K	1.9K	+100.00%
Dec 31, 2025	GLOBAL RETIREMENT PARTNERS, LLC	0%	1.26K	35.02K	1.26K	+100.00%
Dec 31, 2025	SIREN, L.L.C.	4.51%	2M	55.76M	-202.51K	-9.19%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.12%	55.33K	1.54M	3.7K	+7.17%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.01%	4.16K	78.16K	1.95K	+88.01%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.12%	51.63K	971.18K	3.14K	+6.48%
Sep 30, 2025	LONGAEVA PARTNERS L.P.	0.13%	57.06K	1.07M	57.06K	+100.00%
Sep 30, 2025	UBS GROUP AG	0.13%	59.05K	1.11M	-13.29K	-18.37%
Sep 30, 2025	VERITION FUND MANAGEMENT LLC	0.05%	20.13K	378.66K	20.13K	+100.00%
Sep 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.08%	35K	658.35K	0	0
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.12%	51.5K	968.62K	-47.72K	-48.10%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.42%	186.9K	3.52M	32.12K	+20.75%
Sep 30, 2025	SIO CAPITAL MANAGEMENT, LLC	0.43%	189.2K	3.56M	-395.24K	-67.63%
Sep 30, 2025	CHECKPOINT CAPITAL L.P.	0.64%	283.16K	5.33M	-303.32K	-51.72%
Sep 30, 2025	AMERITAS INVESTMENT PARTNERS, INC.	0%	1.94K	36.57K	0	0
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0%	1.9K	35.66K	1.9K	+100.00%
Sep 30, 2025	NUVEEN, LLC	0.05%	23.96K	450.71K	-34.01K	-58.67%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.06%	25.28K	475.57K	25.28K	+100.00%
Sep 30, 2025	RHUMBLINE ADVISERS	0.06%	27.6K	519.22K	-968	-3.39%
Sep 30, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	0.08%	35.78K	672.98K	35.78K	+100.00%
Sep 30, 2025	RANGELEY CAPITAL, LLC	0.2%	88K	1.66M	29.4K	+50.16%
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.21%	92.33K	1.74M	14.69K	+18.92%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.05%	20.15K	378.97K	5.43K	+36.90%
Sep 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.5%	222.7K	4.19M	0	0
Sep 30, 2025	WOODLINE PARTNERS LP	0.64%	282.59K	5.32M	0	0
Sep 30, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.01%	5.18K	97.34K	1.62K	+45.57%
Sep 30, 2025	JPMORGAN CHASE & CO	0.02%	8.74K	164.32K	-1.37K	-13.51%
Sep 30, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0.02%	9.79K	184.17K	-1.91K	-16.29%
Sep 30, 2025	ADVISOR GROUP HOLDINGS, INC.	0.03%	12.86K	241.95K	12.65K	+5,910.75%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	13.69K	257.42K	0	0
Sep 30, 2025	DEUTSCHE BANK AG\	0.03%	14.14K	265.88K	2.01K	+16.60%
Sep 30, 2025	CATALIO CAPITAL MANAGEMENT, LP	0.67%	294.36K	5.54M	0	0
Sep 30, 2025	GROUP ONE TRADING, L.P.	0%	1.69K	31.77M	900	+114.07%
Sep 30, 2025	QUADRATURE CAPITAL LTD	0%	0	-	-10.13K	-100.00%
Sep 30, 2025	SIMPLEX TRADING, LLC	0%	0	-	-23.53K	-100.00%
Sep 30, 2025	JANE STREET GROUP, LLC	0.8%	352.4K	6.63M	-95.9K	-21.39%
Sep 30, 2025	STATE STREET CORP	0.95%	418.96K	7.88M	48.97K	+13.23%
Sep 30, 2025	GSA CAPITAL PARTNERS LLP	0%	0	-	-23.53K	-100.00%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0%	0	-	-12.2K	-100.00%
Sep 30, 2025	STRS OHIO	0%	0	-	-3.4K	-100.00%
Sep 30, 2025	ROTHSCHILD INVESTMENT LLC	0%	30	564	0	0
Sep 30, 2025	STERLING CAPITAL MANAGEMENT LLC	0%	1.48K	27.75K	898	+155.63%
Sep 30, 2025	SIGNATUREFD, LLC	0%	966	18.17K	0	0
Sep 30, 2025	CWM, LLC	0%	884	17K	12	+1.38%
Sep 30, 2025	GAMMA INVESTING LLC	0%	804	15.12K	227	+39.34%
Sep 30, 2025	AMALGAMATED BANK	0%	634	12K	0	0
Sep 30, 2025	US BANCORP \DE\	0%	265	4.99K	0	0
Sep 30, 2025	VERSANT CAPITAL MANAGEMENT, INC	0%	261	4.91K	261	+100.00%
Sep 30, 2025	CITIGROUP INC	0%	249	4.68K	-6.92K	-96.53%
Sep 30, 2025	PNC FINANCIAL SERVICES GROUP, INC.	0%	198	3.72K	198	+100.00%
Sep 30, 2025	NISA INVESTMENT ADVISORS, LLC	0%	143	2.69K	0	0
Sep 30, 2025	FORTITUDE FAMILY OFFICE, LLC	0%	71	1.34K	0	0
Sep 30, 2025	EVERSOURCE WEALTH ADVISORS, LLC	0%	63	1.19K	41	+186.36%
Sep 30, 2025	SBI SECURITIES CO., LTD.	0%	50	941	0	0
Sep 30, 2025	PERCEPTIVE ADVISORS LLC	1.23%	541.45K	10.18M	0	0
Sep 30, 2025	CASDIN CAPITAL, LLC	1.25%	553.27K	10.41M	0	0
Sep 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	2.66%	1.18M	22.13M	329.26K	+38.86%
Sep 30, 2025	VANGUARD GROUP INC	3.44%	1.52M	28.57M	104.39K	+7.38%
Sep 30, 2025	SIREN, L.L.C.	4.99%	2.2M	41.43M	0	0
Sep 30, 2025	TRV GP VI, LLC	9.54%	4.21M	79.22M	0	0
Sep 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	11.14%	4.92M	92.54M	239.47K	+5.12%
Sep 30, 2025	TRV GP V, LLC	14.07%	6.22M	116.92M	0	0
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0%	1.95K	36.59K	0	0
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.01%	2.9K	54.55K	0	0
Sep 30, 2025	FMR LLC	0.01%	3.44K	64.67K	953	+38.35%
Sep 30, 2025	COVESTOR LTD	0.01%	3.62K	68K	1.3K	+55.77%
Sep 30, 2025	BLACKROCK, INC.	3.31%	1.46M	27.46M	69K	+4.96%
Sep 30, 2025	BVF INC/IL	9.09%	4.02M	75.54M	-380.33K	-8.65%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	3.29%	1.45M	27.36M	38.41K	+2.71%
Sep 30, 2025	AVORO CAPITAL ADVISORS LLC	3.03%	1.34M	25.16M	100K	+8.08%
Sep 30, 2025	VR ADVISER, LLC	1.38%	610.81K	11.49M	70.36K	+13.02%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.24%	545.7K	10.27M	57.75K	+11.83%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.87%	384.2K	7.23M	332.26K	+639.64%
Sep 30, 2025	LOGOS GLOBAL MANAGEMENT LP	0.19%	83.55K	1.57M	-25.65K	-23.49%
Sep 30, 2025	WALLEYE CAPITAL LLC	0.18%	80.34K	1.51M	80.34K	+100.00%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.16%	72.6K	1.37M	45K	+163.04%
Sep 30, 2025	MORGAN STANLEY	0.12%	54.46K	1.02M	-30.4K	-35.83%
Sep 30, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.04%	18.26K	343.47K	-57.2K	-75.80%
Sep 30, 2025	TWO SIGMA ADVISERS, LP	0.05%	20.7K	389.37K	20.7K	+100.00%
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	15.84%	7M	131.59M	0	0
Sep 30, 2025	SAMSARA BIOCAPITAL, LLC	7.13%	3.15M	59.24M	0	0
Sep 30, 2025	INVESCO LTD.	0.4%	177.07K	3.33M	165.24K	+1,396.41%
Sep 30, 2025	NORTHERN TRUST CORP	0.38%	167.35K	3.15M	13K	+8.42%
Sep 30, 2025	BARCLAYS PLC	0.07%	30.1K	566.22K	-5.6K	-15.69%
Sep 30, 2025	ALLIANCEBERNSTEIN L.P.	0.05%	22.1K	415.7K	0	0
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.06%	27.42K	516K	2.52K	+10.13%
Jun 30, 2025	VANGUARD GROUP INC	3.2%	1.41M	14.95M	419.32K	+42.14%
Jun 30, 2025	NUVEEN, LLC	0.13%	57.97K	612.75K	34.01K	+141.94%
Jun 30, 2025	RANGELEY CAPITAL, LLC	0.13%	58.61K	619.46K	5.66K	+10.68%
Jun 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.5%	222.7K	2.35M	119.95K	+116.74%
Jun 30, 2025	CATALIO CAPITAL MANAGEMENT, LP	0.67%	294.36K	3.11M	-729.89K	-71.26%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.05%	22.1K	233.6M	22.1K	+100.00%
Jun 30, 2025	MORGAN STANLEY	0.19%	84.86K	896.97M	-6.18K	-6.79%
Jun 30, 2025	CITADEL ADVISORS LLC	0.23%	100.6K	1.06B	89.1K	+774.78%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	3.21%	1.42M	14.97B	-33.09K	-2.28%
Jun 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	10.6%	4.68M	49.47M	1.56M	+49.89%
Jun 30, 2025	TRV GP V, LLC	14.07%	6.22M	65.7M	0	0
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	15.84%	7M	73.95M	0	0
Jun 30, 2025	CONGRESS WEALTH MANAGEMENT LLC / DE /	0.03%	12.59K	133.07K	12.59K	+100.00%
Jun 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	13.69K	144.65K	13.69K	+100.00%
Jun 30, 2025	WELLS FARGO & COMPANY/MN	0.03%	14.72K	155.56K	3.85K	+35.40%
Jun 30, 2025	TUDOR INVESTMENT CORP ET AL	0.04%	16.76K	177.16K	16.76K	+100.00%
Jun 30, 2025	XTX TOPCO LTD	0.05%	22.33K	236.03K	-15.02K	-40.21%
Jun 30, 2025	SIMPLEX TRADING, LLC	0.05%	23.53K	248K	23.53K	+100.00%
Jun 30, 2025	GSA CAPITAL PARTNERS LLP	0.05%	23.53K	249K	5.23K	+28.57%
Jun 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.05%	24.14K	255.18K	24.14K	+100.00%
Jun 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.07%	28.7K	303.36K	28.7K	+100.00%
Jun 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.08%	35K	369.95K	0	0
Jun 30, 2025	BARCLAYS PLC	0.08%	35.71K	377K	12.97K	+57.07%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.11%	48.49K	512.53K	10.11K	+26.35%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.12%	51.94K	549.05K	-384.62K	-88.10%
Jun 30, 2025	UBS GROUP AG	0.16%	72.34K	764.58K	-167.6K	-69.85%
Jun 30, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.17%	75.46K	797.57K	-675.9K	-89.96%
Jun 30, 2025	TWO SIGMA INVESTMENTS, LP	0.18%	77.64K	820.68K	2.8K	+3.74%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.22%	99.21K	1.05M	87.65K	+758.32%
Jun 30, 2025	LOGOS GLOBAL MANAGEMENT LP	0.25%	109.2K	1.15M	-25K	-18.63%
Jun 30, 2025	DEEP TRACK CAPITAL, LP	0.28%	121.72K	1.29M	-1.79M	-93.64%
Jun 30, 2025	NORTHERN TRUST CORP	0.35%	154.34K	1.63M	-3.7K	-2.34%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.35%	154.78K	1.64M	36.33K	+30.67%
Jun 30, 2025		0.13%	57.97K	612.75K	34.01K	+141.94%
Jun 30, 2025	WOODLINE PARTNERS LP	0.64%	282.59K	2.99M	-300K	-51.49%
Jun 30, 2025	STATE STREET CORP	0.84%	369.99K	3.91M	25.39K	+7.37%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.1%	487.96K	5.16M	78.32K	+19.12%
Jun 30, 2025	VR ADVISER, LLC	1.22%	540.45K	5.71M	540.45K	+100.00%
Jun 30, 2025	PERCEPTIVE ADVISORS LLC	1.23%	541.45K	5.72M	541.45K	+100.00%
Jun 30, 2025	CASDIN CAPITAL, LLC	1.25%	553.27K	5.85M	0	0
Jun 30, 2025	SIO CAPITAL MANAGEMENT, LLC	1.32%	584.44K	6.18M	-204.24K	-25.90%
Jun 30, 2025	TRV GP VI, LLC	9.54%	4.21M	44.52M	0	0
Jun 30, 2025	BVF INC/IL	9.95%	4.4M	46.47M	0	0
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.06%	24.9K	264K	1.95K	+8.47%
Jun 30, 2025	RHUMBLINE ADVISERS	0.06%	28.57K	302K	5.25K	+22.53%
Jun 30, 2025	JANE STREET GROUP, LLC	1.02%	448.3K	4.74M	404.3K	+918.86%
Jun 30, 2025	AVORO CAPITAL ADVISORS LLC	2.8%	1.24M	13.08M	-100K	-7.48%
Jun 30, 2025	BLACKROCK, INC.	3.15%	1.39M	14.7M	132.49K	+10.53%
Jun 30, 2025	SIREN, L.L.C.	4.99%	2.2M	23.28M	0	0
Jun 30, 2025	SAMSARA BIOCAPITAL, LLC	7.13%	3.15M	33.29M	0	0
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.06%	27.6K	291.73K	9.3K	+50.82%
Jun 30, 2025	CHECKPOINT CAPITAL L.P.	1.33%	586.47K	6.2M	-238.41K	-28.90%
Jun 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	1.92%	847.23K	8.96M	126.38K	+17.53%
Mar 31, 2025	DEUTSCHE BANK AG\	0.04%	15.97K	92.46K	5.55K	+53.26%
Mar 31, 2025	UBS GROUP AG	0.55%	239.93K	1.39M	131.48K	+121.23%
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	2.23%	720.85K	4.17M	720.85K	+100.00%
Mar 31, 2025	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0.1%	44.36K	256.86K	42.99K	+3,138.10%
Mar 31, 2025	DEEP TRACK CAPITAL, LP	5.91%	1.91M	11.08M	0	0
Mar 31, 2025	GOLDMAN SACHS GROUP INC	3.3%	1.45M	8.39M	-224.96K	-13.44%
Mar 31, 2025	AVORO CAPITAL ADVISORS LLC	3.04%	1.34M	7.74M	227.5K	+20.50%
Mar 31, 2025	BLACKROCK, INC.	2.86%	1.26M	7.29M	-418.82K	-24.97%
Mar 31, 2025	WOODLINE PARTNERS LP	1.33%	582.59K	3.37M	282.59K	+94.20%
Mar 31, 2025	JANE STREET GROUP, LLC	0.1%	44K	254.76K	44K	+100.00%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.09%	38.38K	222.2K	283	+0.74%
Mar 31, 2025	CHECKPOINT CAPITAL L.P.	2.55%	824.88K	4.78M	824.88K	+100.00%
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	21.6%	7M	40.51M	0	0
Mar 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.08%	35K	202.65K	0	0
Mar 31, 2025		0.05%	23.96K	138.73K	23.96K	+100.00%
Mar 31, 2025	MORGAN STANLEY	0.21%	91.04K	527.15K	49.13K	+117.23%
Mar 31, 2025	NORTHERN TRUST CORP	0.36%	158.04K	915.05K	10.26K	+6.95%
Mar 31, 2025	LOGOS GLOBAL MANAGEMENT LP	0.41%	134.2K	777.03K	0	0
Mar 31, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	2.32%	751.35K	4.35M	75.94K	+11.24%
Mar 31, 2025	VANGUARD GROUP INC	2.26%	995.04K	5.76M	10.01K	+1.02%
Mar 31, 2025	CASDIN CAPITAL, LLC	1.71%	553.27K	3.2M	0	0
Mar 31, 2025	LINDBROOK CAPITAL, LLC	0.05%	21K	121.59K	0	0
Mar 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	7.11%	3.12M	18.08M	533.06K	+20.58%
Mar 31, 2025	SIREN, L.L.C.	5.01%	2.2M	12.75M	0	0
Mar 31, 2025	SIO CAPITAL MANAGEMENT, LLC	2.44%	788.67K	4.57M	516.98K	+190.29%
Mar 31, 2025	TRV GP V, LLC	19.19%	6.22M	35.99M	0	0
Mar 31, 2025	BVF INC/IL	13.58%	4.4M	25.45M	1.94M	+79.29%
Mar 31, 2025	TRV GP VI, LLC	13.01%	4.21M	24.39M	1.06M	+33.60%
Mar 31, 2025	CITIGROUP INC	0.09%	38.06K	220.34K	23.42K	+160.06%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	1.35%	436.56K	2.53M	436.56K	+100.00%
Mar 31, 2025	SAMSARA BIOCAPITAL, LLC	9.72%	3.15M	18.23M	380.61K	+13.75%
Mar 31, 2025	STONERIDGE INVESTMENT PARTNERS LLC	0.04%	18.48K	107K	18.48K	+100.00%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.27%	118.45K	685.83K	-21.17K	-15.16%
Mar 31, 2025	SWISS NATIONAL BANK	0.07%	30.1K	174.28K	30.1K	+100.00%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.93%	409.64K	2.37M	29.06K	+7.64%
Mar 31, 2025	STATE STREET CORP	0.78%	344.6K	2M	71.83K	+26.33%
Mar 31, 2025	GSA CAPITAL PARTNERS LLP	0.04%	18.3K	106K	18.3K	+100.00%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.04%	18.3K	105.96K	18.3K	+100.00%
Mar 31, 2025	XTX TOPCO LTD	0.09%	37.35K	216.26K	37.35K	+100.00%
Mar 31, 2025	FMR LLC	0.11%	49.78K	288.22K	-953.18K	-95.04%
Mar 31, 2025	STONEPINE CAPITAL MANAGEMENT, LLC	0.16%	68.08K	394.21K	68.08K	+100.00%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.17%	74.84K	433.33K	74.84K	+100.00%
Mar 31, 2025	RHUMBLINE ADVISERS	0.05%	23.32K	135.01K	3.32K	+16.62%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.05%	22.96K	133K	-495.63K	-95.57%
Mar 31, 2025	BARCLAYS PLC	0.05%	22.73K	132K	-6.05K	-21.02%

Insiders

Among the SEPN insiders holding of 3.07% of the stake in company, THIRD ROCK VENTURES V, L.P., 10 percent owner, holds the largest shares of 6.07M. RA CAPITAL MANAGEMENT, L.P., , is the second largest SEPN insider with ownership of 725.44K shares. BHATT ELIZABETH, President and COO, stands third with possession of 174.21K shares of that stake.

Insiders	Designation	Shares Held
THIRD ROCK VENTURES V, L.P.	10 percent owner	6.07M
RA CAPITAL MANAGEMENT, L.P.		725.44K
BHATT ELIZABETH	President and COO	174.21K
LONG DANIEL D.	SVP, Drug Discovery	96.41K
SHAIKHLY SAMIRA	Chief People Officer	793

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Sep 01, 2026	LONG DANIEL D.	SALE	37.83	3.33K	126.08K	96.41K
Aug 12, 2026	RA CAPITAL MANAGEMENT, L.P.	SALE	42.50	746.5K	31.73M	725.44K
Aug 12, 2026	THIRD ROCK VENTURES V, L.P.	SALE	51.08	141	7.2K	6.07M
Aug 11, 2026	BHATT ELIZABETH	SALE	44.00	25K	1.1M	174.21K
Aug 03, 2026	LONG DANIEL D.	SALE	34.68	2.33K	80.94K	96.41K
Jul 15, 2026	BHATT ELIZABETH	SALE	33.99	4K	135.97K	174.21K
Jul 01, 2026	LONG DANIEL D.	SALE	34.81	1.23K	42.93K	96.41K
Jun 29, 2026	SHAIKHLY SAMIRA	SALE	35.18	2.18K	76.62K	793
Jun 22, 2026	LONG DANIEL D.	SALE	35.97	7K	251.78K	96.41K
Jun 12, 2026	SHAIKHLY SAMIRA	SALE	35.08	6.25K	219.22K	793
Jun 01, 2026	SHAIKHLY SAMIRA	SALE	29.66	2.89K	85.7K	793
May 26, 2026	SHAIKHLY SAMIRA	SALE	30.06	11.8K	354.66K	793
Apr 15, 2026	BHATT ELIZABETH	SALE	25.86	326	8.43K	174.21K
Mar 02, 2026	SHAIKHLY SAMIRA	SALE	28.14	66.36K	1.87M	793
Feb 18, 2026	BHATT ELIZABETH	SALE	29.58	1.8K	53.25K	174.21K
Nov 10, 2025	LONG DANIEL D.	SALE	18.06	3.5K	63.22K	92.91K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES812.98K13

NET SHARES-812.98K13

SHARES HELD7.71M13

% NET SHARES-110.55%0%

Frequently Asked Questions

Stock Outstanding Shares

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares7.43

Short Percent Of Float14.68

Shares Outstanding45.08M

Shares Float23.17M

Shares Short3.35M

Short Ratio5.73

14.68%

Short % of Float

7.43%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

3.07% Percentage of Shares held by All Insiders

98.94% Percentage of Shares held by All Institutions

102.07% Percentage of Float held by Institutions

226

Number of Institutions Holding Shares

Institutional Ownership

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Jun 30, 2026	VIRTUS INVESTMENT ADVISERS, INC.	0.02%	9.1K	304.83K	-1.62K	-15.09%
Jun 30, 2026	SOLEUS CAPITAL MANAGEMENT, L.P.	0.61%	275K	9.21M	0	0
Jun 30, 2026	DIADEMA PARTNERS LP	0.13%	59.7K	2M	59.7K	+100.00%
Jun 30, 2026	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.42%	187.04K	6.26M	5.46K	+3.01%
Jun 30, 2026	LONGAEVA PARTNERS L.P.	0.66%	298.17K	9.99M	223.6K	+299.87%
Jun 30, 2026	BALYASNY ASSET MANAGEMENT L.P.	0.78%	350.44K	11.74M	113.76K	+48.07%
Jun 30, 2026	ALGERT GLOBAL LLC	0.88%	397.49K	13.31M	376.45K	+1,789.65%
Jun 30, 2026	CASDIN CAPITAL, LLC	1.23%	553.27K	18.53M	0	0
Jun 30, 2026	LOOMIS SAYLES & CO L P	1.39%	624.75K	20.92M	624.75K	+100.00%
Jun 30, 2026	STATE STREET CORP	1.45%	652.63K	21.86M	21.18K	+3.35%
Jun 30, 2026	GEODE CAPITAL MANAGEMENT, LLC	1.51%	679.16K	22.75M	34.02K	+5.27%
Jun 30, 2026	WINTON GROUP LTD	0.02%	7.18K	240.53K	-1.66K	-18.77%
Jun 30, 2026	OCCUDO QUANTITATIVE STRATEGIES LP	0.02%	7.19K	240.83K	7.19K	+100.00%
Jun 30, 2026	CAPTION MANAGEMENT, LLC	0.44%	200K	6.7M	200K	+100.00%
Jun 30, 2026	NORTHERN TRUST CORP	0.45%	201.13K	6.74M	36.6K	+22.25%
Jun 30, 2026	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.49%	222.7K	7.46M	-1.29K	-0.58%
Jun 30, 2026	DIMENSIONAL FUND ADVISORS LP	0.17%	75.31K	2.52M	75.31K	+100.00%
Jun 30, 2026	QUANTINNO CAPITAL MANAGEMENT LP	0.02%	7.33K	245.48K	7.33K	+100.00%
Jun 30, 2026	VANGUARD ASSET MANAGEMENT, LTD	0.02%	7.42K	248.5K	0	0
Jun 30, 2026	CREATIVE PLANNING	0.02%	7.64K	255.73K	7.64K	+100.00%
Jun 30, 2026	FIRST TRUST ADVISORS LP	0.02%	7.74K	259.18K	7.74K	+100.00%
Jun 30, 2026	NEW YORK STATE COMMON RETIREMENT FUND	0.02%	8.5K	284.67K	2.9K	+51.79%
Jun 30, 2026	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.02%	9.98K	334.3K	-400	-3.85%
Jun 30, 2026	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	10.77K	360.82K	-1.17K	-9.81%
Jun 30, 2026	VANGUARD GLOBAL ADVISERS, LLC	0.04%	16.25K	544.11K	0	0
Jun 30, 2026	STATE OF WYOMING	0.04%	16.38K	548.53K	16.38K	+100.00%
Jun 30, 2026	LOS ANGELES CAPITAL MANAGEMENT LLC	0.04%	16.6K	555.83K	2.38K	+16.77%
Jun 30, 2026	BNP PARIBAS ARBITRAGE, SNC	0.04%	16.95K	567.52K	11.59K	+216.10%
Jun 30, 2026	CITIGROUP INC	0.04%	17.81K	596.39K	8.61K	+93.67%
Jun 30, 2026	FRANKLIN RESOURCES INC	0.04%	18.61K	623.15K	18.61K	+100.00%
Jun 30, 2026	SWISS NATIONAL BANK	0.04%	19.8K	663.1K	-2.3K	-10.41%
Jun 30, 2026	JUMP FINANCIAL, LLC	0.05%	20.2K	676.5K	-32.81K	-61.89%
Jun 30, 2026	ACADIAN ASSET MANAGEMENT LLC	0.05%	21K	701K	-9.98K	-32.22%
Jun 30, 2026	STRS OHIO	0.05%	21K	703.29K	3.8K	+22.09%
Jun 30, 2026	DEUTSCHE BANK AG\	0.05%	21.87K	732.53K	5.03K	+29.86%
Jun 30, 2026	FOX RUN MANAGEMENT, L.L.C.	0.05%	22.04K	738.05K	22.04K	+100.00%
Jun 30, 2026	FMR LLC	0.05%	23.24K	778.31K	-206	-0.88%
Jun 30, 2026	RHUMBLINE ADVISERS	0.06%	27.64K	925.52K	1.03K	+3.88%
Jun 30, 2026	RUSSELL INVESTMENTS GROUP, LTD.	0.09%	40.21K	1.35M	28.69K	+249.19%
Jun 30, 2026	RENAISSANCE TECHNOLOGIES LLC	0.09%	41.42K	1.39M	3.72K	+9.86%
Jun 30, 2026	NUVEEN, LLC	0.11%	48.23K	1.62M	19.05K	+65.30%
Jun 30, 2026	BANK OF NEW YORK MELLON CORP	0.13%	56.18K	1.88M	-2.53K	-4.31%
Jun 30, 2026		0.43%	194.54K	6.52M	0	0
Jun 30, 2026	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.58%	262K	8.77M	189K	+258.90%
Jun 30, 2026	DRIEHAUS CAPITAL MANAGEMENT LLC	9.84%	4.43M	148.46M	37.49K	+0.85%
Jun 30, 2026	RA CAPITAL MANAGEMENT, L.P.	15.53%	7M	234.29M	0	0
Jun 30, 2026	TWO SIGMA INVESTMENTS, LP	0.49%	220.89K	7.4M	145.52K	+193.08%
Jun 30, 2026	FIRST LIGHT ASSET MANAGEMENT, LLC	2.14%	963.26K	32.26M	230.4K	+31.44%
Jun 30, 2026	PRIMECAP MANAGEMENT CO/CA/	2.59%	1.17M	39.1M	118.55K	+11.30%
Jun 30, 2026	VANGUARD CAPITAL MANAGEMENT LLC	2.71%	1.22M	40.91M	24.71K	+2.06%
Jun 30, 2026	AVORO CAPITAL ADVISORS LLC	2.97%	1.34M	44.79M	0	0
Jun 30, 2026	SIREN, L.L.C.	4.22%	1.9M	63.63M	-100K	-5.00%
Jun 30, 2026	BLACKROCK, INC.	4.29%	1.93M	64.71M	109.91K	+6.03%
Jun 30, 2026	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	0.17%	74.65K	2.5M	74.65K	+100.00%
Jun 30, 2026	GOLDMAN SACHS GROUP INC	6.8%	3.06M	102.57M	156.34K	+5.38%
Jun 30, 2026	SAMSARA BIOCAPITAL, LLC	6.99%	3.15M	105.46M	0	0
Jun 30, 2026	LAZARD ASSET MANAGEMENT LLC	0.17%	75.43K	2.53M	75.43K	+100.00%
Jun 30, 2026	CITADEL ADVISORS LLC	0.18%	81.8K	2.74M	81.8K	+100.00%
Jun 30, 2026	JANE STREET GROUP, LLC	0.13%	57.2K	1.92M	57.2K	+100.00%
Jun 30, 2026	HUSSMAN STRATEGIC ADVISORS, INC.	0.14%	63K	2.11M	-42K	-40.00%
Jun 30, 2026	UBS GROUP AG	0.2%	89.87K	3.01M	-27.11K	-23.17%
Jun 30, 2026	TUDOR INVESTMENT CORP ET AL	0.22%	100K	3.35M	100K	+100.00%
Jun 30, 2026	MORGAN STANLEY	0.3%	134.38K	4.5M	23.85K	+21.58%
Jun 30, 2026	VANGUARD FIDUCIARY TRUST CO	0.37%	165.66K	5.55M	11.17K	+7.23%
Jun 30, 2026	VANGUARD PORTFOLIO MANAGEMENT LLC	0.51%	230.18K	7.71M	35.14K	+18.02%
Jun 30, 2026	CATALIO CAPITAL MANAGEMENT, LP	1.19%	536.15K	17.96M	241.79K	+82.14%
Jun 30, 2026	ADAR1 CAPITAL MANAGEMENT, LLC	2.09%	940.75K	31.51M	-149.07K	-13.68%
Jun 30, 2026	JUPITER TOPCO LLC	2.9%	1.31M	43.72M	1.31M	+100.00%
Jun 30, 2026	TRV GP VI, LLC	9.35%	4.21M	141.05M	0	0
Jun 30, 2026	TRV GP V, LLC	13.8%	6.22M	208.16M	0	0
Jun 30, 2026	AMERICAN CENTURY COMPANIES INC	0.14%	60.97K	2.04M	-317	-0.52%
Jun 30, 2026	JACOBS LEVY EQUITY MANAGEMENT, INC	0.15%	68.18K	2.28M	39.74K	+139.77%
Jun 30, 2026	JPMORGAN CHASE & CO	0.19%	85.3K	2.96M	627	+0.74%
Jun 30, 2026	FEDERATED HERMES, INC.	0.19%	86.75K	2.91M	-2.55K	-2.85%
Jun 30, 2026	WOODLINE PARTNERS LP	0.41%	185.54K	6.21M	185.54K	+100.00%
Jun 30, 2026	SIXTH STREET PARTNERS MANAGEMENT COMPANY, L.P.	0.42%	187.04K	6.26M	187.04K	+100.00%
Jun 30, 2026	KALEHUA CAPITAL MANAGEMENT LLC	0.43%	194.54K	6.52M	0	0
Mar 31, 2026	AMERICAN CENTURY COMPANIES INC	0.14%	61.29K	1.47M	10.6K	+20.91%
Mar 31, 2026	LONGAEVA PARTNERS L.P.	0.17%	74.57K	1.79M	24.67K	+49.43%
Mar 31, 2026	TWO SIGMA INVESTMENTS, LP	0.17%	75.37K	1.81M	-17.44K	-18.79%
Mar 31, 2026	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.16%	73K	1.75M	3.8K	+5.49%
Mar 31, 2026	STATE STREET CORP	1.41%	631.45K	15.17M	91.42K	+16.93%
Mar 31, 2026	DRIEHAUS CAPITAL MANAGEMENT LLC	9.82%	4.4M	105.63M	-413.9K	-8.61%
Mar 31, 2026	RA CAPITAL MANAGEMENT, L.P.	15.63%	7M	168.11M	0	0
Mar 31, 2026	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.5%	224K	5.38M	1.29K	+0.58%
Mar 31, 2026	SOFINNOVA INVESTMENTS, INC.	0.11%	47.51K	1.14M	47.51K	+100.00%
Mar 31, 2026	BLACKROCK, INC.	4.07%	1.82M	43.79M	20.85K	+1.16%
Mar 31, 2026	GOLDMAN SACHS GROUP INC	6.49%	2.91M	69.84M	191.3K	+7.05%
Mar 31, 2026	MILLENNIUM MANAGEMENT LLC	0.28%	124.1K	2.98M	16.64K	+15.48%
Mar 31, 2026	SIREN, L.L.C.	4.47%	2M	48.06M	0	0
Mar 31, 2026	VANGUARD CAPITAL MANAGEMENT LLC	2.67%	1.2M	28.76M	1.2M	+100.00%
Mar 31, 2026	SAMSARA BIOCAPITAL, LLC	7.04%	3.15M	75.67M	0	0
Mar 31, 2026	NUVEEN, LLC	0.07%	29.18K	701.1K	3.38K	+13.09%
Mar 31, 2026	XTX TOPCO LTD	0.08%	36.72K	882.45K	13.41K	+57.51%
Mar 31, 2026	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.41%	181.58K	4.36M	-5.66K	-3.02%
Mar 31, 2026		0.43%	194.54K	4.67M	0	0
Mar 31, 2026	TRV GP VI, LLC	9.41%	4.21M	101.21M	0	0
Mar 31, 2026	VANGUARD FIDUCIARY TRUST CO	0.35%	154.48K	3.71M	154.48K	+100.00%
Mar 31, 2026	NORTHERN TRUST CORP	0.37%	164.53K	3.95M	10.33K	+6.70%
Mar 31, 2026	TREXQUANT INVESTMENT LP	0.08%	35.3K	848.28K	-8.7K	-19.78%
Mar 31, 2026	UBS GROUP AG	0.26%	116.98K	2.81M	48.16K	+69.99%
Mar 31, 2026	ACADIAN ASSET MANAGEMENT LLC	0.07%	30.98K	741K	101	+0.33%
Mar 31, 2026	RANGELEY CAPITAL, LLC	0.09%	39.8K	956.39K	-26K	-39.51%
Mar 31, 2026	MARSHALL WACE, LLP	0.09%	39.84K	957.35K	-187.06K	-82.44%
Mar 31, 2026	JUMP FINANCIAL, LLC	0.12%	53.01K	1.27M	44.61K	+531.16%
Mar 31, 2026	INVESCO LTD.	0.19%	82.87K	1.99M	-79.15K	-48.85%
Mar 31, 2026	ADAR1 CAPITAL MANAGEMENT, LLC	2.43%	1.09M	26.19M	-67.79K	-5.86%
Mar 31, 2026	AVORO CAPITAL ADVISORS LLC	2.99%	1.34M	32.14M	0	0
Mar 31, 2026	BVF INC/IL	3.02%	1.35M	32.52M	-367.53K	-21.36%
Mar 31, 2026	JPMORGAN CHASE & CO	0.19%	84.67K	1.97M	16.34K	+23.90%
Mar 31, 2026	FEDERATED HERMES, INC.	0.2%	89.3K	2.15M	10.4K	+13.18%
Mar 31, 2026	CHECKPOINT CAPITAL L.P.	0.22%	100.3K	2.41M	100.3K	+100.00%
Mar 31, 2026	HUSSMAN STRATEGIC ADVISORS, INC.	0.23%	105K	2.52M	105K	+100.00%
Mar 31, 2026	ALYESKA INVESTMENT GROUP, L.P.	0.08%	35K	841.05K	0	0
Mar 31, 2026	BANK OF NEW YORK MELLON CORP	0.13%	58.71K	1.41M	3.38K	+6.10%
Mar 31, 2026	MORGAN STANLEY	0.25%	110.53K	2.66M	6.55K	+6.29%
Mar 31, 2026	BALYASNY ASSET MANAGEMENT L.P.	0.53%	236.68K	5.69M	233.11K	+6,527.81%
Mar 31, 2026	RENAISSANCE TECHNOLOGIES LLC	0.08%	37.7K	905.93K	37.7K	+100.00%
Mar 31, 2026	SOLEUS CAPITAL MANAGEMENT, L.P.	0.61%	275K	6.61M	-108.37K	-28.27%
Mar 31, 2026	CATALIO CAPITAL MANAGEMENT, LP	0.66%	294.36K	7.07M	0	0
Mar 31, 2026	VR ADVISER, LLC	1.13%	506.06K	12.16M	-104.75K	-17.15%
Mar 31, 2026	CASDIN CAPITAL, LLC	1.24%	553.27K	13.3M	0	0
Mar 31, 2026	GEODE CAPITAL MANAGEMENT, LLC	1.44%	645.15K	15.51M	72.41K	+12.64%
Mar 31, 2026	FIRST LIGHT ASSET MANAGEMENT, LLC	1.64%	732.86K	17.61M	112.05K	+18.05%
Mar 31, 2026	JANUS HENDERSON GROUP PLC	1.99%	890.75K	21.33M	890.75K	+100.00%
Mar 31, 2026	PRIMECAP MANAGEMENT CO/CA/	2.34%	1.05M	25.2M	502.73K	+92.06%
Mar 31, 2026	EVERSOURCE WEALTH ADVISORS, LLC	0%	1.17K	45.16K	1.11K	+1,753.97%
Mar 31, 2026	AMERITAS INVESTMENT PARTNERS, INC.	0%	1.94K	46.71K	0	0
Mar 31, 2026	COVESTOR LTD	0.01%	2.26K	54K	319	+16.43%
Mar 31, 2026	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.01%	2.34K	56.11K	159	+7.31%
Mar 31, 2026	KLP KAPITALFORVALTNING AS	0.01%	2.5K	60.08K	2.5K	+100.00%
Mar 31, 2026	PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO	0.01%	3.37K	81.08K	-7.22K	-68.15%
Mar 31, 2026	VANGUARD INVESTMENTS AUSTRALIA, LTD.	0.01%	3.9K	93.6K	3.9K	+100.00%
Mar 31, 2026	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.01%	5.18K	124.36K	0	0
Mar 31, 2026	BNP PARIBAS ARBITRAGE, SNC	0.01%	5.36K	128.83K	-88	-1.62%
Mar 31, 2026	NEW YORK STATE COMMON RETIREMENT FUND	0.01%	5.6K	134.57K	0	0
Mar 31, 2026	LEGAL & GENERAL GROUP PLC	0.01%	5.74K	137.81K	3.79K	+194.86%
Mar 31, 2026	VANGUARD ASSET MANAGEMENT, LTD	0.02%	7.42K	178.3K	7.42K	+100.00%
Mar 31, 2026	WINTON GROUP LTD	0.02%	8.84K	212.47K	8.84K	+100.00%
Mar 31, 2026	CITIGROUP INC	0.02%	9.2K	220.96K	-366	-3.83%
Mar 31, 2026	WELLS FARGO & COMPANY/MN	0.02%	9.87K	237.15K	-16.66K	-62.80%
Mar 31, 2026	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.02%	10.38K	249.48K	10.38K	+100.00%
Mar 31, 2026	VIRTUS INVESTMENT ADVISERS, INC.	0.02%	10.72K	257.58K	262	+2.51%
Mar 31, 2026	RUSSELL INVESTMENTS GROUP, LTD.	0.03%	11.52K	276.71K	-3.8K	-24.79%
Mar 31, 2026	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.03%	11.95K	287.06K	1.65K	+16.03%
Mar 31, 2026	ENTRYPOINT CAPITAL, LLC	0.03%	12.78K	307.01K	12.78K	+100.00%
Mar 31, 2026	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	13.69K	328.85K	0	0
Mar 31, 2026	LOS ANGELES CAPITAL MANAGEMENT LLC	0.03%	14.21K	341.56K	-4.34K	-23.37%
Mar 31, 2026	VANGUARD GLOBAL ADVISERS, LLC	0.04%	16.25K	390.42K	16.25K	+100.00%
Mar 31, 2026	DEUTSCHE BANK AG\	0.04%	16.84K	404.74K	1.96K	+13.20%
Mar 31, 2026	STRS OHIO	0.04%	17.2K	413.32K	2.6K	+17.81%
Mar 31, 2026	ALGERT GLOBAL LLC	0.05%	21.04K	505K	-13.91K	-39.80%
Mar 31, 2026	SWISS NATIONAL BANK	0.05%	22.1K	531.06K	22.1K	+100.00%
Mar 31, 2026	Y-INTERCEPT (HONG KONG) LTD	0.06%	25.77K	619.25K	25.77K	+100.00%
Mar 31, 2026	RHUMBLINE ADVISERS	0.06%	26.6K	639.29K	185	+0.70%
Mar 31, 2026	TRV GP V, LLC	13.89%	6.22M	149.36M	0	0
Dec 31, 2025	DYNAMIC TECHNOLOGY LAB PRIVATE LTD	0.02%	10.81K	301K	10.81K	+100.00%
Dec 31, 2025	RA CAPITAL MANAGEMENT, L.P.	15.78%	7M	195.04M	0	0
Dec 31, 2025	VR ADVISER, LLC	1.38%	610.81K	17.03M	0	0
Dec 31, 2025	NORTHERN TRUST CORP	0.35%	154.2K	4.3M	-13.15K	-7.86%
Dec 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.08%	35K	975.8K	0	0
Dec 31, 2025	DEUTSCHE BANK AG\	0.03%	14.88K	414.83K	744	+5.26%
Dec 31, 2025	STRS OHIO	0.03%	14.6K	407.05K	14.6K	+100.00%
Dec 31, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	10.3K	287.05K	10.3K	+100.00%
Dec 31, 2025	BAADER BANK AKTIENGESELLSCHAFT	0.02%	10K	278.8K	10K	+100.00%
Dec 31, 2025	CITIGROUP INC	0.02%	9.56K	266.56K	9.31K	+3,739.76%
Dec 31, 2025	JUMP FINANCIAL, LLC	0.02%	8.4K	234.16K	8.4K	+100.00%
Dec 31, 2025	BANK OF NOVA SCOTIA	0.02%	8.3K	231.4K	8.3K	+100.00%
Dec 31, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.01%	5.6K	156.13K	2.7K	+93.10%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.01%	5.45K	151.92K	1.29K	+31.14%
Dec 31, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.01%	5.18K	144.28K	0	0
Dec 31, 2025	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0%	2.18K	60.67K	2.18K	+100.00%
Dec 31, 2025	LEGAL & GENERAL GROUP PLC	0%	1.95K	54.17K	0	0
Dec 31, 2025	BVF INC/IL	3.88%	1.72M	47.98M	-2.3M	-57.15%
Dec 31, 2025	FIRST LIGHT ASSET MANAGEMENT, LLC	1.4%	620.81K	17.31M	620.81K	+100.00%
Dec 31, 2025	RHUMBLINE ADVISERS	0.06%	26.42K	736.55M	-1.19K	-4.29%
Dec 31, 2025	BLACKROCK, INC.	4.06%	1.8M	50.22M	341.53K	+23.40%
Dec 31, 2025	VANGUARD GROUP INC	3.4%	1.51M	42.05M	-10.56K	-0.70%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.29%	572.73K	15.97M	27.03K	+4.95%
Dec 31, 2025	PRIMECAP MANAGEMENT CO/CA/	1.23%	546.1K	15.23M	546.1K	+100.00%
Dec 31, 2025	STATE STREET CORP	1.22%	540.03K	15.06M	121.07K	+28.90%
Dec 31, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.86%	383.37K	10.69M	365.11K	+1,999.50%
Dec 31, 2025		0.44%	194.54K	5.42M	194.54K	+100.00%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.42%	187.24K	5.22M	337	+0.18%
Dec 31, 2025	INVESCO LTD.	0.37%	162.01K	4.52M	-15.06K	-8.50%
Dec 31, 2025	AMERICAN CENTURY COMPANIES INC	0.11%	50.69K	1.41M	25.41K	+100.49%
Dec 31, 2025	JANE STREET GROUP, LLC	0.1%	44.07K	1.23M	44.07K	+100.00%
Dec 31, 2025	BARCLAYS PLC	0.09%	38.15K	1.06M	8.05K	+26.73%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	0.08%	37.59K	1.05M	-13.9K	-26.99%
Dec 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	10.85%	4.81M	134.09M	-110.43K	-2.24%
Dec 31, 2025	SAMSARA BIOCAPITAL, LLC	7.1%	3.15M	87.8M	0	0
Dec 31, 2025	AVORO CAPITAL ADVISORS LLC	3.02%	1.34M	37.29M	0	0
Dec 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	2.61%	1.16M	32.27M	-18.88K	-1.60%
Dec 31, 2025	CASDIN CAPITAL, LLC	1.25%	553.27K	15.43M	0	0
Dec 31, 2025	PERCEPTIVE ADVISORS LLC	0.98%	433.16K	12.08M	-108.29K	-20.00%
Dec 31, 2025	WOODLINE PARTNERS LP	0.87%	385.31K	10.74M	102.73K	+36.35%
Dec 31, 2025	CATALIO CAPITAL MANAGEMENT, LP	0.66%	294.36K	8.21M	0	0
Dec 31, 2025	MORGAN STANLEY	0.23%	103.99K	2.9M	49.53K	+90.95%
Dec 31, 2025	FEDERATED HERMES, INC.	0.18%	78.91K	2.2M	78.91K	+100.00%
Dec 31, 2025	HIGHVISTA STRATEGIES LLC	0.18%	78.68K	2.19M	78.68K	+100.00%
Dec 31, 2025	UBS GROUP AG	0.16%	68.82K	1.92M	9.77K	+16.55%
Dec 31, 2025	JPMORGAN CHASE & CO	0.15%	68.34K	1.91M	59.6K	+682.26%
Dec 31, 2025	RANGELEY CAPITAL, LLC	0.15%	65.8K	1.83M	-22.2K	-25.23%
Dec 31, 2025	LONGAEVA PARTNERS L.P.	0.11%	49.9K	1.39M	-7.16K	-12.55%
Dec 31, 2025	NUMERAI GP LLC	0.1%	45.87K	1.28M	45.87K	+100.00%
Dec 31, 2025	TREXQUANT INVESTMENT LP	0.1%	44.01K	1.23M	44.01K	+100.00%
Dec 31, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.09%	37.87K	1.06M	37.87K	+100.00%
Dec 31, 2025	MARSHALL WACE, LLP	0.51%	226.9K	6.33M	226.9K	+100.00%
Dec 31, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.5%	222.7K	6.21M	0	0
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	0.24%	107.46K	3M	-276.74K	-72.03%
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.16%	69.2K	1.93M	-3.4K	-4.68%
Dec 31, 2025	TWO SIGMA INVESTMENTS, LP	0.21%	92.81K	2.59M	475	+0.51%
Dec 31, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	0.14%	61.37K	1.71M	25.59K	+71.53%
Dec 31, 2025	ACADIAN ASSET MANAGEMENT LLC	0.07%	30.88K	858K	30.88K	+100.00%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.06%	26.53K	739.63K	6.38K	+31.68%
Dec 31, 2025	NUVEEN, LLC	0.06%	25.8K	719.25K	1.84K	+7.67%
Dec 31, 2025	TWO SIGMA ADVISERS, LP	0.06%	25.7K	716.52K	5K	+24.15%
Dec 31, 2025	LOGOS GLOBAL MANAGEMENT LP	0.05%	23.55K	656.52K	-60K	-71.82%
Dec 31, 2025	XTX TOPCO LTD	0.05%	23.32K	650.02K	23.32K	+100.00%
Dec 31, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.04%	18.55K	398.64K	18.55K	+100.00%
Dec 31, 2025	TUDOR INVESTMENT CORP ET AL	0.04%	18.05K	503.32K	18.05K	+100.00%
Dec 31, 2025	FRANKLIN RESOURCES INC	0.04%	16.85K	469.83K	16.85K	+100.00%
Dec 31, 2025	SQUAREPOINT OPS LLC	0.03%	14.85K	413.93K	14.85K	+100.00%
Dec 31, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	13.69K	381.54K	0	0
Dec 31, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	13.28K	370.33K	13.28K	+100.00%
Dec 31, 2025	ADVISOR GROUP HOLDINGS, INC.	0.03%	12.69K	353.88K	-170	-1.32%
Dec 31, 2025	CITADEL ADVISORS LLC	0.17%	75.95K	2.12M	75.95K	+100.00%
Dec 31, 2025	VIRTUS INVESTMENT ADVISERS, INC.	0.02%	10.46K	291.54K	10.46K	+100.00%
Dec 31, 2025	TRV GP V, LLC	14.02%	6.22M	173.29M	0	0
Dec 31, 2025	TRV GP VI, LLC	9.5%	4.21M	117.42M	0	0
Dec 31, 2025	GOLDMAN SACHS GROUP INC	6.12%	2.72M	75.7M	1.26M	+86.64%
Dec 31, 2025	AMERITAS INVESTMENT PARTNERS, INC.	0%	1.94K	54.2K	0	0
Dec 31, 2025	COVESTOR LTD	0%	1.94K	54K	-1.68K	-46.38%
Dec 31, 2025	CAITONG INTERNATIONAL ASSET MANAGEMENT CO., LTD	0%	1.9K	53K	1.9K	+100.00%
Dec 31, 2025	GLOBAL RETIREMENT PARTNERS, LLC	0%	1.26K	35.02K	1.26K	+100.00%
Dec 31, 2025	SIREN, L.L.C.	4.51%	2M	55.76M	-202.51K	-9.19%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.12%	55.33K	1.54M	3.7K	+7.17%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.01%	4.16K	78.16K	1.95K	+88.01%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.12%	51.63K	971.18K	3.14K	+6.48%
Sep 30, 2025	LONGAEVA PARTNERS L.P.	0.13%	57.06K	1.07M	57.06K	+100.00%
Sep 30, 2025	UBS GROUP AG	0.13%	59.05K	1.11M	-13.29K	-18.37%
Sep 30, 2025	VERITION FUND MANAGEMENT LLC	0.05%	20.13K	378.66K	20.13K	+100.00%
Sep 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.08%	35K	658.35K	0	0
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.12%	51.5K	968.62K	-47.72K	-48.10%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.42%	186.9K	3.52M	32.12K	+20.75%
Sep 30, 2025	SIO CAPITAL MANAGEMENT, LLC	0.43%	189.2K	3.56M	-395.24K	-67.63%
Sep 30, 2025	CHECKPOINT CAPITAL L.P.	0.64%	283.16K	5.33M	-303.32K	-51.72%
Sep 30, 2025	AMERITAS INVESTMENT PARTNERS, INC.	0%	1.94K	36.57K	0	0
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0%	1.9K	35.66K	1.9K	+100.00%
Sep 30, 2025	NUVEEN, LLC	0.05%	23.96K	450.71K	-34.01K	-58.67%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.06%	25.28K	475.57K	25.28K	+100.00%
Sep 30, 2025	RHUMBLINE ADVISERS	0.06%	27.6K	519.22K	-968	-3.39%
Sep 30, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	0.08%	35.78K	672.98K	35.78K	+100.00%
Sep 30, 2025	RANGELEY CAPITAL, LLC	0.2%	88K	1.66M	29.4K	+50.16%
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.21%	92.33K	1.74M	14.69K	+18.92%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.05%	20.15K	378.97K	5.43K	+36.90%
Sep 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.5%	222.7K	4.19M	0	0
Sep 30, 2025	WOODLINE PARTNERS LP	0.64%	282.59K	5.32M	0	0
Sep 30, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.01%	5.18K	97.34K	1.62K	+45.57%
Sep 30, 2025	JPMORGAN CHASE & CO	0.02%	8.74K	164.32K	-1.37K	-13.51%
Sep 30, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0.02%	9.79K	184.17K	-1.91K	-16.29%
Sep 30, 2025	ADVISOR GROUP HOLDINGS, INC.	0.03%	12.86K	241.95K	12.65K	+5,910.75%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	13.69K	257.42K	0	0
Sep 30, 2025	DEUTSCHE BANK AG\	0.03%	14.14K	265.88K	2.01K	+16.60%
Sep 30, 2025	CATALIO CAPITAL MANAGEMENT, LP	0.67%	294.36K	5.54M	0	0
Sep 30, 2025	GROUP ONE TRADING, L.P.	0%	1.69K	31.77M	900	+114.07%
Sep 30, 2025	QUADRATURE CAPITAL LTD	0%	0	-	-10.13K	-100.00%
Sep 30, 2025	SIMPLEX TRADING, LLC	0%	0	-	-23.53K	-100.00%
Sep 30, 2025	JANE STREET GROUP, LLC	0.8%	352.4K	6.63M	-95.9K	-21.39%
Sep 30, 2025	STATE STREET CORP	0.95%	418.96K	7.88M	48.97K	+13.23%
Sep 30, 2025	GSA CAPITAL PARTNERS LLP	0%	0	-	-23.53K	-100.00%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0%	0	-	-12.2K	-100.00%
Sep 30, 2025	STRS OHIO	0%	0	-	-3.4K	-100.00%
Sep 30, 2025	ROTHSCHILD INVESTMENT LLC	0%	30	564	0	0
Sep 30, 2025	STERLING CAPITAL MANAGEMENT LLC	0%	1.48K	27.75K	898	+155.63%
Sep 30, 2025	SIGNATUREFD, LLC	0%	966	18.17K	0	0
Sep 30, 2025	CWM, LLC	0%	884	17K	12	+1.38%
Sep 30, 2025	GAMMA INVESTING LLC	0%	804	15.12K	227	+39.34%
Sep 30, 2025	AMALGAMATED BANK	0%	634	12K	0	0
Sep 30, 2025	US BANCORP \DE\	0%	265	4.99K	0	0
Sep 30, 2025	VERSANT CAPITAL MANAGEMENT, INC	0%	261	4.91K	261	+100.00%
Sep 30, 2025	CITIGROUP INC	0%	249	4.68K	-6.92K	-96.53%
Sep 30, 2025	PNC FINANCIAL SERVICES GROUP, INC.	0%	198	3.72K	198	+100.00%
Sep 30, 2025	NISA INVESTMENT ADVISORS, LLC	0%	143	2.69K	0	0
Sep 30, 2025	FORTITUDE FAMILY OFFICE, LLC	0%	71	1.34K	0	0
Sep 30, 2025	EVERSOURCE WEALTH ADVISORS, LLC	0%	63	1.19K	41	+186.36%
Sep 30, 2025	SBI SECURITIES CO., LTD.	0%	50	941	0	0
Sep 30, 2025	PERCEPTIVE ADVISORS LLC	1.23%	541.45K	10.18M	0	0
Sep 30, 2025	CASDIN CAPITAL, LLC	1.25%	553.27K	10.41M	0	0
Sep 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	2.66%	1.18M	22.13M	329.26K	+38.86%
Sep 30, 2025	VANGUARD GROUP INC	3.44%	1.52M	28.57M	104.39K	+7.38%
Sep 30, 2025	SIREN, L.L.C.	4.99%	2.2M	41.43M	0	0
Sep 30, 2025	TRV GP VI, LLC	9.54%	4.21M	79.22M	0	0
Sep 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	11.14%	4.92M	92.54M	239.47K	+5.12%
Sep 30, 2025	TRV GP V, LLC	14.07%	6.22M	116.92M	0	0
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0%	1.95K	36.59K	0	0
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.01%	2.9K	54.55K	0	0
Sep 30, 2025	FMR LLC	0.01%	3.44K	64.67K	953	+38.35%
Sep 30, 2025	COVESTOR LTD	0.01%	3.62K	68K	1.3K	+55.77%
Sep 30, 2025	BLACKROCK, INC.	3.31%	1.46M	27.46M	69K	+4.96%
Sep 30, 2025	BVF INC/IL	9.09%	4.02M	75.54M	-380.33K	-8.65%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	3.29%	1.45M	27.36M	38.41K	+2.71%
Sep 30, 2025	AVORO CAPITAL ADVISORS LLC	3.03%	1.34M	25.16M	100K	+8.08%
Sep 30, 2025	VR ADVISER, LLC	1.38%	610.81K	11.49M	70.36K	+13.02%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.24%	545.7K	10.27M	57.75K	+11.83%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.87%	384.2K	7.23M	332.26K	+639.64%
Sep 30, 2025	LOGOS GLOBAL MANAGEMENT LP	0.19%	83.55K	1.57M	-25.65K	-23.49%
Sep 30, 2025	WALLEYE CAPITAL LLC	0.18%	80.34K	1.51M	80.34K	+100.00%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.16%	72.6K	1.37M	45K	+163.04%
Sep 30, 2025	MORGAN STANLEY	0.12%	54.46K	1.02M	-30.4K	-35.83%
Sep 30, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.04%	18.26K	343.47K	-57.2K	-75.80%
Sep 30, 2025	TWO SIGMA ADVISERS, LP	0.05%	20.7K	389.37K	20.7K	+100.00%
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	15.84%	7M	131.59M	0	0
Sep 30, 2025	SAMSARA BIOCAPITAL, LLC	7.13%	3.15M	59.24M	0	0
Sep 30, 2025	INVESCO LTD.	0.4%	177.07K	3.33M	165.24K	+1,396.41%
Sep 30, 2025	NORTHERN TRUST CORP	0.38%	167.35K	3.15M	13K	+8.42%
Sep 30, 2025	BARCLAYS PLC	0.07%	30.1K	566.22K	-5.6K	-15.69%
Sep 30, 2025	ALLIANCEBERNSTEIN L.P.	0.05%	22.1K	415.7K	0	0
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.06%	27.42K	516K	2.52K	+10.13%
Jun 30, 2025	VANGUARD GROUP INC	3.2%	1.41M	14.95M	419.32K	+42.14%
Jun 30, 2025	NUVEEN, LLC	0.13%	57.97K	612.75K	34.01K	+141.94%
Jun 30, 2025	RANGELEY CAPITAL, LLC	0.13%	58.61K	619.46K	5.66K	+10.68%
Jun 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.5%	222.7K	2.35M	119.95K	+116.74%
Jun 30, 2025	CATALIO CAPITAL MANAGEMENT, LP	0.67%	294.36K	3.11M	-729.89K	-71.26%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.05%	22.1K	233.6M	22.1K	+100.00%
Jun 30, 2025	MORGAN STANLEY	0.19%	84.86K	896.97M	-6.18K	-6.79%
Jun 30, 2025	CITADEL ADVISORS LLC	0.23%	100.6K	1.06B	89.1K	+774.78%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	3.21%	1.42M	14.97B	-33.09K	-2.28%
Jun 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	10.6%	4.68M	49.47M	1.56M	+49.89%
Jun 30, 2025	TRV GP V, LLC	14.07%	6.22M	65.7M	0	0
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	15.84%	7M	73.95M	0	0
Jun 30, 2025	CONGRESS WEALTH MANAGEMENT LLC / DE /	0.03%	12.59K	133.07K	12.59K	+100.00%
Jun 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	13.69K	144.65K	13.69K	+100.00%
Jun 30, 2025	WELLS FARGO & COMPANY/MN	0.03%	14.72K	155.56K	3.85K	+35.40%
Jun 30, 2025	TUDOR INVESTMENT CORP ET AL	0.04%	16.76K	177.16K	16.76K	+100.00%
Jun 30, 2025	XTX TOPCO LTD	0.05%	22.33K	236.03K	-15.02K	-40.21%
Jun 30, 2025	SIMPLEX TRADING, LLC	0.05%	23.53K	248K	23.53K	+100.00%
Jun 30, 2025	GSA CAPITAL PARTNERS LLP	0.05%	23.53K	249K	5.23K	+28.57%
Jun 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.05%	24.14K	255.18K	24.14K	+100.00%
Jun 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.07%	28.7K	303.36K	28.7K	+100.00%
Jun 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.08%	35K	369.95K	0	0
Jun 30, 2025	BARCLAYS PLC	0.08%	35.71K	377K	12.97K	+57.07%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.11%	48.49K	512.53K	10.11K	+26.35%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.12%	51.94K	549.05K	-384.62K	-88.10%
Jun 30, 2025	UBS GROUP AG	0.16%	72.34K	764.58K	-167.6K	-69.85%
Jun 30, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.17%	75.46K	797.57K	-675.9K	-89.96%
Jun 30, 2025	TWO SIGMA INVESTMENTS, LP	0.18%	77.64K	820.68K	2.8K	+3.74%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.22%	99.21K	1.05M	87.65K	+758.32%
Jun 30, 2025	LOGOS GLOBAL MANAGEMENT LP	0.25%	109.2K	1.15M	-25K	-18.63%
Jun 30, 2025	DEEP TRACK CAPITAL, LP	0.28%	121.72K	1.29M	-1.79M	-93.64%
Jun 30, 2025	NORTHERN TRUST CORP	0.35%	154.34K	1.63M	-3.7K	-2.34%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.35%	154.78K	1.64M	36.33K	+30.67%
Jun 30, 2025		0.13%	57.97K	612.75K	34.01K	+141.94%
Jun 30, 2025	WOODLINE PARTNERS LP	0.64%	282.59K	2.99M	-300K	-51.49%
Jun 30, 2025	STATE STREET CORP	0.84%	369.99K	3.91M	25.39K	+7.37%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.1%	487.96K	5.16M	78.32K	+19.12%
Jun 30, 2025	VR ADVISER, LLC	1.22%	540.45K	5.71M	540.45K	+100.00%
Jun 30, 2025	PERCEPTIVE ADVISORS LLC	1.23%	541.45K	5.72M	541.45K	+100.00%
Jun 30, 2025	CASDIN CAPITAL, LLC	1.25%	553.27K	5.85M	0	0
Jun 30, 2025	SIO CAPITAL MANAGEMENT, LLC	1.32%	584.44K	6.18M	-204.24K	-25.90%
Jun 30, 2025	TRV GP VI, LLC	9.54%	4.21M	44.52M	0	0
Jun 30, 2025	BVF INC/IL	9.95%	4.4M	46.47M	0	0
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.06%	24.9K	264K	1.95K	+8.47%
Jun 30, 2025	RHUMBLINE ADVISERS	0.06%	28.57K	302K	5.25K	+22.53%
Jun 30, 2025	JANE STREET GROUP, LLC	1.02%	448.3K	4.74M	404.3K	+918.86%
Jun 30, 2025	AVORO CAPITAL ADVISORS LLC	2.8%	1.24M	13.08M	-100K	-7.48%
Jun 30, 2025	BLACKROCK, INC.	3.15%	1.39M	14.7M	132.49K	+10.53%
Jun 30, 2025	SIREN, L.L.C.	4.99%	2.2M	23.28M	0	0
Jun 30, 2025	SAMSARA BIOCAPITAL, LLC	7.13%	3.15M	33.29M	0	0
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.06%	27.6K	291.73K	9.3K	+50.82%
Jun 30, 2025	CHECKPOINT CAPITAL L.P.	1.33%	586.47K	6.2M	-238.41K	-28.90%
Jun 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	1.92%	847.23K	8.96M	126.38K	+17.53%
Mar 31, 2025	DEUTSCHE BANK AG\	0.04%	15.97K	92.46K	5.55K	+53.26%
Mar 31, 2025	UBS GROUP AG	0.55%	239.93K	1.39M	131.48K	+121.23%
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	2.23%	720.85K	4.17M	720.85K	+100.00%
Mar 31, 2025	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0.1%	44.36K	256.86K	42.99K	+3,138.10%
Mar 31, 2025	DEEP TRACK CAPITAL, LP	5.91%	1.91M	11.08M	0	0
Mar 31, 2025	GOLDMAN SACHS GROUP INC	3.3%	1.45M	8.39M	-224.96K	-13.44%
Mar 31, 2025	AVORO CAPITAL ADVISORS LLC	3.04%	1.34M	7.74M	227.5K	+20.50%
Mar 31, 2025	BLACKROCK, INC.	2.86%	1.26M	7.29M	-418.82K	-24.97%
Mar 31, 2025	WOODLINE PARTNERS LP	1.33%	582.59K	3.37M	282.59K	+94.20%
Mar 31, 2025	JANE STREET GROUP, LLC	0.1%	44K	254.76K	44K	+100.00%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.09%	38.38K	222.2K	283	+0.74%
Mar 31, 2025	CHECKPOINT CAPITAL L.P.	2.55%	824.88K	4.78M	824.88K	+100.00%
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	21.6%	7M	40.51M	0	0
Mar 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.08%	35K	202.65K	0	0
Mar 31, 2025		0.05%	23.96K	138.73K	23.96K	+100.00%
Mar 31, 2025	MORGAN STANLEY	0.21%	91.04K	527.15K	49.13K	+117.23%
Mar 31, 2025	NORTHERN TRUST CORP	0.36%	158.04K	915.05K	10.26K	+6.95%
Mar 31, 2025	LOGOS GLOBAL MANAGEMENT LP	0.41%	134.2K	777.03K	0	0
Mar 31, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	2.32%	751.35K	4.35M	75.94K	+11.24%
Mar 31, 2025	VANGUARD GROUP INC	2.26%	995.04K	5.76M	10.01K	+1.02%
Mar 31, 2025	CASDIN CAPITAL, LLC	1.71%	553.27K	3.2M	0	0
Mar 31, 2025	LINDBROOK CAPITAL, LLC	0.05%	21K	121.59K	0	0
Mar 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	7.11%	3.12M	18.08M	533.06K	+20.58%
Mar 31, 2025	SIREN, L.L.C.	5.01%	2.2M	12.75M	0	0
Mar 31, 2025	SIO CAPITAL MANAGEMENT, LLC	2.44%	788.67K	4.57M	516.98K	+190.29%
Mar 31, 2025	TRV GP V, LLC	19.19%	6.22M	35.99M	0	0
Mar 31, 2025	BVF INC/IL	13.58%	4.4M	25.45M	1.94M	+79.29%
Mar 31, 2025	TRV GP VI, LLC	13.01%	4.21M	24.39M	1.06M	+33.60%
Mar 31, 2025	CITIGROUP INC	0.09%	38.06K	220.34K	23.42K	+160.06%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	1.35%	436.56K	2.53M	436.56K	+100.00%
Mar 31, 2025	SAMSARA BIOCAPITAL, LLC	9.72%	3.15M	18.23M	380.61K	+13.75%
Mar 31, 2025	STONERIDGE INVESTMENT PARTNERS LLC	0.04%	18.48K	107K	18.48K	+100.00%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.27%	118.45K	685.83K	-21.17K	-15.16%
Mar 31, 2025	SWISS NATIONAL BANK	0.07%	30.1K	174.28K	30.1K	+100.00%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.93%	409.64K	2.37M	29.06K	+7.64%
Mar 31, 2025	STATE STREET CORP	0.78%	344.6K	2M	71.83K	+26.33%
Mar 31, 2025	GSA CAPITAL PARTNERS LLP	0.04%	18.3K	106K	18.3K	+100.00%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.04%	18.3K	105.96K	18.3K	+100.00%
Mar 31, 2025	XTX TOPCO LTD	0.09%	37.35K	216.26K	37.35K	+100.00%
Mar 31, 2025	FMR LLC	0.11%	49.78K	288.22K	-953.18K	-95.04%
Mar 31, 2025	STONEPINE CAPITAL MANAGEMENT, LLC	0.16%	68.08K	394.21K	68.08K	+100.00%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.17%	74.84K	433.33K	74.84K	+100.00%
Mar 31, 2025	RHUMBLINE ADVISERS	0.05%	23.32K	135.01K	3.32K	+16.62%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.05%	22.96K	133K	-495.63K	-95.57%
Mar 31, 2025	BARCLAYS PLC	0.05%	22.73K	132K	-6.05K	-21.02%

Insiders

Insiders	Designation	Shares Held
THIRD ROCK VENTURES V, L.P.	10 percent owner	6.07M
RA CAPITAL MANAGEMENT, L.P.		725.44K
BHATT ELIZABETH	President and COO	174.21K
LONG DANIEL D.	SVP, Drug Discovery	96.41K
SHAIKHLY SAMIRA	Chief People Officer	793

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Sep 01, 2026	LONG DANIEL D.	SALE	37.83	3.33K	126.08K	96.41K
Aug 12, 2026	RA CAPITAL MANAGEMENT, L.P.	SALE	42.50	746.5K	31.73M	725.44K
Aug 12, 2026	THIRD ROCK VENTURES V, L.P.	SALE	51.08	141	7.2K	6.07M
Aug 11, 2026	BHATT ELIZABETH	SALE	44.00	25K	1.1M	174.21K
Aug 03, 2026	LONG DANIEL D.	SALE	34.68	2.33K	80.94K	96.41K
Jul 15, 2026	BHATT ELIZABETH	SALE	33.99	4K	135.97K	174.21K
Jul 01, 2026	LONG DANIEL D.	SALE	34.81	1.23K	42.93K	96.41K
Jun 29, 2026	SHAIKHLY SAMIRA	SALE	35.18	2.18K	76.62K	793
Jun 22, 2026	LONG DANIEL D.	SALE	35.97	7K	251.78K	96.41K
Jun 12, 2026	SHAIKHLY SAMIRA	SALE	35.08	6.25K	219.22K	793
Jun 01, 2026	SHAIKHLY SAMIRA	SALE	29.66	2.89K	85.7K	793
May 26, 2026	SHAIKHLY SAMIRA	SALE	30.06	11.8K	354.66K	793
Apr 15, 2026	BHATT ELIZABETH	SALE	25.86	326	8.43K	174.21K
Mar 02, 2026	SHAIKHLY SAMIRA	SALE	28.14	66.36K	1.87M	793
Feb 18, 2026	BHATT ELIZABETH	SALE	29.58	1.8K	53.25K	174.21K
Nov 10, 2025	LONG DANIEL D.	SALE	18.06	3.5K	63.22K	92.91K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES812.98K13

NET SHARES-812.98K13

SHARES HELD7.71M13

% NET SHARES-110.55%0%

SEPN Stock Ownership Breakdown

Septerna

Stock Outstanding Shares

Market Insider

Institutional Ownership

Insiders

Buying/Selling by Insiders

Insider Transaction Summary (6 Months)

Frequently Asked Questions

Stock Outstanding Shares

Market Insider

Institutional Ownership

Insiders

Buying/Selling by Insiders

Insider Transaction Summary (6 Months)

Frequently Asked Questions