OBIO Company Profile and Key Details

Short-term trend indicators are mixed aligned (SMA20 9.47%, SMA50 3.93%, SMA200 24.81%). The stock’s 14-day RSI is 57.84 (neutral), while the ATR of 0.28 points to higher daily volatility. The stock remains hovering near 52-week lows, trading -20.17% below its high and over 96.82% above its low. Average 10-day trading volume of 356.63 thousand shares is in line with the 3-month average of 362.34 thousand, indicating normal recent market interest.

Orchestra BioMed Holdings, Inc. generated EPS of -$1.82 over the past year. Five-year average earnings growth is -273.68%. Wall Street analysts project EPS growth of 8.52% annually over the next five years. The latest quarter delivered EPS of -$0.38. The next quarter is forecast at -$0.38. Next year's EPS is expected at -$12.75. Analyst sentiment is bullish. Analyst rating data shows there are 3 Strong Buy ratings, 6 Buy ratings, 0 Hold ratings, 0 Sell rating and 0 Strong Sell ratings. Price targets range from $20.00 to $10.00. The high target offers 244.23% upside. The low target suggests 72.12% downside. The mean target is $13.44. This offers 131.33% upside. Orchestra BioMed Holdings, Inc. earnings surprise history is a mixed track record. The quarter that ended August 10, 2026, missed forecasts by -3.06%. The prior quarter beat by -23.34%. Over the last six quarters, Apple has recorded several small beats. These include 0.0% in April 02, 2025.

Orchestra BioMed Holdings, Inc. has 60.11 million shares outstanding. The public float is 32.95 million shares, elevated short interest at 6.55% of float. This equals 2.43 million shares. The short ratio is 10.96 days. Institutional investors hold 56.05% of the float. Insiders own 24.57%. RTW INVESTMENTS, LP holds 9.56 million shares, PERCEPTIVE ADVISORS LLC has 1.50 million shares and Sherman Darren has 1.13 million shares. Over the past six months, insider transactions show net buying. They sold 60.03 thousand shares across 5 transactions.

Orchestra BioMed Holdings, Inc. last paid a dividend of 0 per share, Dividend and splits history remains an important factor for investors monitoring long-term returns. A discounted cash flow model estimates fair value at around -$5.85. This means the shares are trading below this model’s fair value.

Orchestra BioMed Holdings, Inc. (NASDAQ:OBIO) closed at $5.81 USD, gaining $0.36 (6.61%) from the previous close of $5.45. The stock is currently within 5% of its 52-week high $2.20 and $6.07. With a market capitalization of about $347.91 million, Orchestra BioMed Holdings, Inc. is classified as a small-cap and shows lower-than-market volatility (beta ~0.53). Key stats such as the average daily volume over the past year has been around 357.35 thousand shares, trading with heavier-than-usual volume. Headquartered in New Hope, PA, Orchestra BioMed Holdings, Inc. operates in the Healthcare sector and the Biotechnology industry. Led by CEO David Hochman, the company employs approximately 86 people and listed since August 04, 2020. Orchestra BioMed Holdings, Inc. operates as an innovative company in the biomedical sector.

Orchestra BioMed Holdings, Inc. trades at a P/E ratio of -6.05, slightly below the S&P 500 average, with a price-to-sales ratio of 11.22 and a price-to-book ratio of 12.99 reflecting a rich premium to book value. The P/FCF stands at -6.07, also below market averages. Compared to sector medians, Orchestra BioMed Holdings, Inc. P/S is trading rich, and the P/B is far lower than peers, underscoring the brand and earnings power premium investors assign to the stock.

Our AI price prediction model suggests that Orchestra BioMed Holdings, Inc. stock has strong potential for upside but may face short-term weakness followed by gains in the medium and long term. 2-Week Outlook: Projected decline of -6.54%, with price expected at $5.43 by September 23, 2026, within a range of $5.14 to $5.74 3-Month Outlook: Projected rise of 156.63%, reaching $14.91 by December 08, 2026, with a range of $14.54 to $15.43. 1-Year Outlook: Projected gain of 333.73%, with price at $25.20 by September 09, 2027, within a range of $20.53 to $32.85.

Orchestra BioMed Holdings, Inc. (NASDAQ:OBIO) shares are flat -2.65% year-to-date currently trading near 52-week highs band. Short-term momentum has been positive over the last quarter, despite recent volatility. Valuation shows Orchestra BioMed Holdings, Inc. trading at a premium to the broader market with a P/E of -6.05. Analyst sentiment is bullish, with the majority of ratings in Buy territory and a mean price target of $15.61, suggesting 168.67% upside. Our AI forecast model points to short-term weakness (-6.54% over two weeks), a medium-term rise (156.63% over three months), and a longer-term gain (333.73% over one year), with expected trading ranges indicating moderate volatility.