How many institutions own UPB stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own UPB shares is 134, representing 87.63% of the company's common stock.

Who are the major shareholders selling Upstream Bio, Inc. stock?

RHUMBLINE ADVISERS, in the last quarter, reduced its stake in UPB by -15.96% restricting it's holding to 41.52 thousand shares of worth nearly $1.13B. BNP PARIBAS ARBITRAGE, SNC also lessened -23.76% of the UPB shares from its portfolio, reducing its holding to 4.98 thousand shares of worth $135.10K. CITIGROUP INC also shunned UPB shares holding by -83.47% last quarter which brought its holding to 6.95 thousand shares worth $188.67K.

Investors who are buying UPB stock?

As per its latest 13F filing, EXOME ASSET MANAGEMENT LLC increased its stake in UPB by 24.8% in the last quarter. The institutional holder raised its holding to 64.85 thousand shares having worth more than $1.76M. AMERICAN CENTURY COMPANIES INC also added 22.67% more shares of UPB to its portfolio, raising its holding to 87.76 thousand shares of worth $2.38M. ALYESKA INVESTMENT GROUP, L.P. also increased its UPB shares holding by 100% which brought its holding to 298.33 thousand shares worth $8.10M.

UPB's major insiders: who are they?

The insider with the most stakes in UPB is Sutherland Everett Rand , Chief Executive Officer at the company. Additionally, UPB stock is highly held by Chief Medical Officer Deykin Aaron and CFO and COO GRAY MICHAEL among others.

Did an insider recently sell UPB stock?

Company executives, directors, and other insiders own 14.77% percent of Upstream Bio, Inc.'s stock. Within the last six months, there have been 5 transaction(s) in which UPB insiders have sold stock, totaling 5.01K shares. Insiders that have sold shares include GRAY MICHAEL, DEYKIN AARON, and SUTHERLAND EVERETT RAND.

Which insider recently purchased UPB stock?

There have been 0 transaction(s) during the past 6-months in which Upstream Bio, Inc. insiders have bought stock, totalling 0 shares

How much of UPB does insiders own?

Around 176.07K Upstream Bio, Inc. shares are held by insiders, which represents about 14.77% of UPB stock.

Who is the insider with the largest stake?

UPB Chief Executive Officer, Sutherland Everett Rand holds the largest portfolio of the company's shares. UPB shares owned by Sutherland total nearly 72.91 thousand.

Which institution holds the most shares in UPB?

RHUMBLINE ADVISERS is the largest institutional owner in UPB which holds 41.52 thousand shares worth $1.13B or 0.08% of the total UPB shares outstanding followed by EXOME ASSET MANAGEMENT LLC with ownership of 64.85 thousand shares representing 0.12% of the UPB ownership. AMERICAN CENTURY COMPANIES INC is the third largest stakeholder with 87.76 thousand shares or 0.16% of the ownership worth more than $2.38M.

Is Upstream Bio, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the UPB is concerned, it is a stock which is optionable.

Is there a short position on UPB's shares?

Number of UPB shares short is 3.10M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding UPB shares are there?

As of today, 53.91M shares of UPB are outstanding.

Is there many float in UPB stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, UPB has 31.42M shares in float.

UPB short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for UPB is 6.78.

Upstream Bio (UPB) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares5.75

Short Percent Of Float10.38

Shares Outstanding53.91M

Shares Float31.42M

Shares Short3.10M

Short Ratio6.78

10.38%

Short % of Float

5.75%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

14.77% Percentage of Shares held by All Insiders

87.63% Percentage of Shares held by All Institutions

102.82% Percentage of Float held by Institutions

134

Number of Institutions Holding Shares

Institutional Ownership

About 87.63% of UPB shares are held by financial institutions. RHUMBLINE ADVISERS is the top corporate investor, holding 41.52K shares valued at $1.13B. A 0.08% stake in Upstream Bio, Inc. is owned by the company. EXOME ASSET MANAGEMENT LLC owns 64.85K shares valued at $1.76M, which translates its holding of 0.12% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	RHUMBLINE ADVISERS	0.08%	41.52K	1.13B	-7.88K	-15.96%
Dec 31, 2025	EXOME ASSET MANAGEMENT LLC	0.12%	64.85K	1.76M	12.89K	+24.80%
Dec 31, 2025	AMERICAN CENTURY COMPANIES INC	0.16%	87.76K	2.38M	16.22K	+22.67%
Dec 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.55%	298.33K	8.1M	298.33K	+100.00%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.01%	4.98K	135.1K	-1.55K	-23.76%
Dec 31, 2025	SG AMERICAS SECURITIES, LLC	0.01%	5.52K	150K	5.52K	+100.00%
Dec 31, 2025	CITIGROUP INC	0.01%	6.95K	188.67K	-35.09K	-83.47%
Dec 31, 2025	SEI INVESTMENTS CO	0.02%	8.09K	219.56K	8.09K	+100.00%
Dec 31, 2025	PROSHARE ADVISORS LLC	0.02%	8.35K	226.81K	8.35K	+100.00%
Dec 31, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	8.81K	239.08K	8.81K	+100.00%
Dec 31, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.02%	9.46K	256.73K	9	+0.10%
Dec 31, 2025	STRS OHIO	0.02%	9.8K	266.07K	9.8K	+100.00%
Dec 31, 2025	VERITION FUND MANAGEMENT LLC	0.02%	12.02K	326.34K	-34.98K	-74.43%
Dec 31, 2025	DNB ASSET MANAGEMENT AS	0.02%	12.79K	347.33K	12.79K	+100.00%
Dec 31, 2025	SIREN, L.L.C.	1.09%	588.45K	15.98M	-200K	-25.37%
Dec 31, 2025	DEUTSCHE BANK AG\	0.24%	127.82K	3.47M	101.08K	+378.05%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.53%	284.93K	7.74M	103	+0.04%
Dec 31, 2025	JENNISON ASSOCIATES LLC	0.54%	288.85K	7.84M	288.85K	+100.00%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	0.62%	333.48K	9.05M	110.27K	+49.40%
Dec 31, 2025	MARSHALL WACE, LLP	0.64%	343.79K	9.33M	-524.21K	-60.39%
Dec 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.43%	773.15K	20.99M	773.15K	+100.00%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.58%	851.91K	23.13M	34.8K	+4.26%
Dec 31, 2025	STATE STREET CORP	2.45%	1.32M	35.82M	204.65K	+18.36%
Dec 31, 2025	UBS GROUP AG	3.35%	1.81M	49.04M	1.53M	+563.40%
Dec 31, 2025	VANGUARD GROUP INC	4.43%	2.39M	64.85M	-54.11K	-2.22%
Dec 31, 2025	NORGES BANK	5.35%	2.88M	78.26M	2.88M	+100.00%
Dec 31, 2025	DECHENG CAPITAL LLC	5.83%	3.14M	85.33M	-142.22K	-4.33%
Dec 31, 2025	BLACKROCK, INC.	6.2%	3.34M	90.8M	740.8K	+28.45%
Dec 31, 2025	VIRTUS INVESTMENT ADVISERS, INC.	0.02%	9.8K	266.1K	-42	-0.43%
Dec 31, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.02%	10.15K	275.49K	-1.95K	-16.09%
Dec 31, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.02%	10.4K	282.25K	0	0
Dec 31, 2025	ALPS ADVISORS INC	0.08%	44.38K	1.2M	18.41K	+70.93%
Dec 31, 2025	Y-INTERCEPT (HONG KONG) LTD	0.09%	46.56K	1.26M	46.56K	+100.00%
Dec 31, 2025	SEVEN GRAND MANAGERS, LLC	0.09%	50K	1.36M	50K	+100.00%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	0.16%	86.38K	2.35M	30.91K	+55.72%
Dec 31, 2025	STERLING CAPITAL MANAGEMENT LLC	0%	1.92K	52.1K	-345	-15.24%
Dec 31, 2025	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0%	2.63K	71.3K	2.63K	+100.00%
Dec 31, 2025	BOXER CAPITAL MANAGEMENT, LLC	0.28%	150K	4.07M	150K	+100.00%
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	0.96%	517.26K	14.04M	477.15K	+1,189.52%
Dec 31, 2025	PARKMAN HEALTHCARE PARTNERS LLC	1.55%	834.56K	22.66M	-8.94K	-1.06%
Dec 31, 2025	AMERIPRISE FINANCIAL INC	0.1%	56.56K	1.54M	56.56K	+100.00%
Dec 31, 2025	ARTIA GLOBAL PARTNERS LP	0.13%	68.65K	1.86M	68.65K	+100.00%
Dec 31, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.14%	75.4K	2.05M	75.4K	+100.00%
Dec 31, 2025	NUVEEN, LLC	0.15%	78.57K	2.13M	8.69K	+12.43%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.16%	84.85K	2.3M	-6.67K	-7.29%
Dec 31, 2025	JPMORGAN CHASE & CO	0.2%	110.28K	2.99M	80.33K	+268.25%
Dec 31, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.21%	115.81K	3.14M	-74.44K	-39.13%
Dec 31, 2025	SUMMITTX CAPITAL, L.P.	0.22%	116.72K	3.17M	4.32K	+3.84%
Dec 31, 2025	AMERITAS INVESTMENT PARTNERS, INC.	0.01%	2.74K	74.42K	0	0
Dec 31, 2025	KLP KAPITALFORVALTNING AS	0.01%	2.9K	78.74K	2.9K	+100.00%
Dec 31, 2025	CWM, LLC	0.01%	3.36K	91K	19	+0.57%
Dec 31, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	0.92%	494.97K	13.44M	-100K	-16.81%
Dec 31, 2025	BARCLAYS PLC	0.97%	524.5K	14.24M	439.18K	+514.78%
Dec 31, 2025	MORGAN STANLEY	0.23%	122.07K	3.31M	34.53K	+39.45%
Dec 31, 2025	INVESCO LTD.	0.3%	163.19K	4.43M	146K	+849.31%
Dec 31, 2025	NORTHERN TRUST CORP	0.44%	236.8K	6.43M	-17.92K	-7.04%
Dec 31, 2025	GREAT POINT PARTNERS LLC	0.56%	300K	8.15M	0	0
Dec 31, 2025	VESTAL POINT CAPITAL, LP	1.33%	720K	19.55M	720K	+100.00%
Dec 31, 2025	SAMSARA BIOCAPITAL, LLC	1.36%	736.05K	19.98M	-226.11K	-23.50%
Dec 31, 2025	TCG CROSSOVER MANAGEMENT, LLC	1.38%	743.89K	20.2M	-1.37M	-64.86%
Dec 31, 2025	INTEGRAL HEALTH ASSET MANAGEMENT, LLC	1.39%	750K	20.36M	175K	+30.43%
Dec 31, 2025	WOODLINE PARTNERS LP	1.41%	760.25K	20.64M	158K	+26.23%
Dec 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	1.66%	894.73K	24.29M	-230.66K	-20.50%
Dec 31, 2025	VR ADVISER, LLC	2.17%	1.17M	31.75M	0	0
Dec 31, 2025	OMEGA FUND MANAGEMENT, LLC	2.46%	1.33M	36.01M	-30K	-2.21%
Dec 31, 2025	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	2.47%	1.33M	36.1M	-1.11M	-45.50%
Dec 31, 2025	ALTSHULER SHAHAM LTD	2.49%	1.34M	36.42M	-75.28K	-5.31%
Dec 31, 2025	JANUS HENDERSON GROUP PLC	2.83%	1.53M	41.42M	1.53M	+100.00%
Dec 31, 2025	ENAVATE SCIENCES GP, LLC	4.56%	2.46M	66.78M	0	0
Dec 31, 2025	ORBIMED ADVISORS LLC	10.56%	5.69M	154.58M	0	0
Dec 31, 2025	FMR LLC	13.94%	7.52M	204.12M	-568.21K	-7.03%
Dec 31, 2025	TWO SIGMA INVESTMENTS, LP	0.02%	10.5K	285.08K	0	0
Dec 31, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.02%	11.7K	317.66K	5.4K	+85.71%
Dec 31, 2025	MARINER, LLC	0.02%	11.83K	321.17K	897	+8.20%
Dec 31, 2025	CITADEL ADVISORS LLC	0.02%	13.42K	364.35M	13.42K	+100.00%
Dec 31, 2025	LEGAL & GENERAL GROUP PLC	0.03%	13.71K	372.2K	10.79K	+368.84%
Dec 31, 2025	PROFUND ADVISORS LLC	0.03%	14.58K	395.9K	14.58K	+100.00%
Dec 31, 2025	XTX TOPCO LTD	0.03%	15.09K	409.72K	15.09K	+100.00%
Dec 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.03%	16.4K	445.26K	16.4K	+100.00%
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.03%	16.5K	447.98K	16.5K	+100.00%
Dec 31, 2025		0.43%	230.65K	6.26M	230.65K	+100.00%
Dec 31, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	19.68K	534.26K	-2.01K	-9.28%
Dec 31, 2025	SWISS NATIONAL BANK	0.05%	26.6K	722.19K	26.6K	+100.00%
Dec 31, 2025	AQR CAPITAL MANAGEMENT LLC	0.06%	30.5K	828.16K	549	+1.83%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.07%	36.79K	998.96K	11.63K	+46.24%
Dec 31, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.07%	38.68K	1.05M	4.16K	+12.06%
Sep 30, 2025	EVERSOURCE WEALTH ADVISORS, LLC	0%	310	5.83K	1	+0.32%
Sep 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.11%	61.3K	1.15M	61.3K	+100.00%
Sep 30, 2025	UBS GROUP AG	0.51%	272.27K	5.12M	39.38K	+16.91%
Sep 30, 2025	CAPTION MANAGEMENT, LLC	0.13%	70K	1.32M	70K	+100.00%
Sep 30, 2025	NORTHERN TRUST CORP	0.47%	254.72K	4.79M	25.42K	+11.08%
Sep 30, 2025	SUMMITTX CAPITAL, L.P.	0.21%	112.4K	2.11M	112.4K	+100.00%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.14%	73.13K	1.38M	73.13K	+100.00%
Sep 30, 2025	NUVEEN, LLC	0.13%	69.88K	1.31M	-4.05K	-5.48%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.1%	55.47K	1.04M	37.44K	+207.65%
Sep 30, 2025	RHUMBLINE ADVISERS	0.09%	49.41K	929.32K	1.34K	+2.79%
Sep 30, 2025	VERITION FUND MANAGEMENT LLC	0.09%	47K	884.09K	13.5K	+40.28%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.07%	40.11K	754.53K	40.11K	+100.00%
Sep 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.06%	29.95K	563.43K	202	+0.68%
Sep 30, 2025	JPMORGAN CHASE & CO	0.06%	29.95K	563.3K	13.48K	+81.84%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	0.42%	223.21K	4.2M	223.21K	+100.00%
Sep 30, 2025	DIADEMA PARTNERS LP	0.37%	200K	3.76M	200K	+100.00%
Sep 30, 2025	BARCLAYS PLC	0.16%	85.32K	1.6M	-11.68K	-12.04%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.13%	71.54K	1.35M	49.18K	+219.92%
Sep 30, 2025	EXOME ASSET MANAGEMENT LLC	0.1%	51.96K	977.37K	51.96K	+100.00%
Sep 30, 2025	CITIGROUP INC	0.08%	42.04K	790.72K	30.34K	+259.44%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.06%	34.52K	649.34K	34.52K	+100.00%
Sep 30, 2025	CITADEL ADVISORS LLC	0.05%	28.3K	532.32K	28.3K	+100.00%
Sep 30, 2025	NOMURA HOLDINGS INC	0.05%	28.29K	532.14K	28.29K	+100.00%
Sep 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.35%	190.24K	3.58M	-175.55K	-47.99%
Sep 30, 2025	IKARIAN CAPITAL, LLC	0.3%	161.11K	3.03M	161.11K	+100.00%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.17%	91.52K	1.72M	11.76K	+14.74%
Sep 30, 2025	DEUTSCHE BANK AG\	0.05%	26.74K	502.92K	3.33K	+14.25%
Sep 30, 2025	ALPS ADVISORS INC	0.05%	25.96K	488.35K	-3.01K	-10.40%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.05%	25.16K	473.26K	2.8K	+12.50%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	21.69K	408.01K	0	0
Sep 30, 2025	JANE STREET GROUP, LLC	0.04%	20.5K	385.61M	20.5K	+100.00%
Sep 30, 2025	SIG BROKERAGE, LP	0.04%	20K	376.2K	20K	+100.00%
Sep 30, 2025	ALLIANCEBERNSTEIN L.P.	0.04%	19.85K	373.38K	-4.71K	-19.18%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.03%	18.5K	349K	1.05K	+6.04%
Sep 30, 2025	INVESCO LTD.	0.03%	17.19K	323.34K	890	+5.46%
Sep 30, 2025	COMMONWEALTH EQUITY SERVICES, LLC	0.03%	15.5K	292K	-23	-0.15%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.02%	10.4K	195.55K	-10.89K	-51.17%
Sep 30, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.02%	9.45K	177.7K	1.61K	+20.61%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.01%	6.53K	122.77K	3.43K	+110.75%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.01%	6.3K	118.5K	1.6K	+34.04%
Sep 30, 2025	CWM, LLC	0.01%	3.34K	63K	29	+0.88%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.01%	3.03K	57.07K	2.89K	+1,963.95%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.01%	2.92K	55K	-250	-7.88%
Sep 30, 2025	AMERITAS INVESTMENT PARTNERS, INC.	0.01%	2.74K	51.56K	-817	-22.96%
Sep 30, 2025	STERLING CAPITAL MANAGEMENT LLC	0%	2.26K	42.59K	1.32K	+140.60%
Sep 30, 2025	GROUP ONE TRADING, L.P.	0%	1.31K	24.55M	1.31K	+100.00%
Sep 30, 2025	ASTER CAPITAL MANAGEMENT (DIFC) LTD	0%	1.14K	21.46K	1.14K	+100.00%
Sep 30, 2025	GAMMA INVESTING LLC	0%	890	16.74K	197	+28.43%
Sep 30, 2025	AMALGAMATED BANK	0%	594	11K	0	0
Sep 30, 2025	VERSANT CAPITAL MANAGEMENT, INC	0%	548	10.31K	-10	-1.79%
Sep 30, 2025	US BANCORP \DE\	0%	531	9.99K	-128	-19.42%
Sep 30, 2025	GLOBAL RETIREMENT PARTNERS, LLC	0%	332	6.25K	332	+100.00%
Sep 30, 2025	CLEARSTEAD ADVISORS, LLC	0%	163	3.07K	0	0
Sep 30, 2025	PNC FINANCIAL SERVICES GROUP, INC.	0%	130	2.45K	130	+100.00%
Sep 30, 2025	J.SAFRA ASSET MANAGEMENT CORP	0%	128	2.41K	128	+100.00%
Sep 30, 2025	NISA INVESTMENT ADVISORS, LLC	0%	96	1.81K	0	0
Sep 30, 2025	N.E.W. ADVISORY SERVICES LLC	0%	60	1.13K	60	+100.00%
Sep 30, 2025	SIGNATUREFD, LLC	0%	51	959	2	+4.08%
Sep 30, 2025	PARALLEL ADVISORS, LLC	0%	2	38	0	0
Sep 30, 2025	STRS OHIO	0%	0	-	-1.8K	-100.00%
Sep 30, 2025	LYNX1 CAPITAL MANAGEMENT LP	0%	0	-	-219.25K	-100.00%
Sep 30, 2025	TRUE WEALTH DESIGN, LLC	0%	0	-	-31	-100.00%
Sep 30, 2025	MORGAN STANLEY	0.16%	87.54K	1.65M	-11.77K	-11.86%
Sep 30, 2025	FMR LLC	15.04%	8.09M	152.11M	149.53K	+1.88%
Sep 30, 2025	ORBIMED ADVISORS LLC	10.59%	5.69M	107.1M	0	0
Sep 30, 2025	DECHENG CAPITAL LLC	6.11%	3.29M	61.8M	0	0
Sep 30, 2025	BLACKROCK, INC.	4.84%	2.6M	48.98M	507.2K	+24.19%
Sep 30, 2025	ENAVATE SCIENCES GP, LLC	4.57%	2.46M	46.27M	0	0
Sep 30, 2025	VANGUARD GROUP INC	4.54%	2.44M	45.94M	271.72K	+12.52%
Sep 30, 2025	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	4.54%	2.44M	45.89M	0	0
Sep 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	3.94%	2.12M	39.82M	-684.66K	-24.44%
Sep 30, 2025	ALTSHULER SHAHAM LTD	2.63%	1.42M	26.65M	-1.98M	-58.26%
Sep 30, 2025	OMEGA FUND MANAGEMENT, LLC	2.52%	1.36M	25.51M	-680K	-33.39%
Sep 30, 2025	VR ADVISER, LLC	2.17%	1.17M	21.99M	-1.13M	-49.06%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	2.09%	1.13M	21.17M	-99.9K	-8.15%
Sep 30, 2025	STATE STREET CORP	2.07%	1.11M	20.97M	633.21K	+131.54%
Sep 30, 2025	SAMSARA BIOCAPITAL, LLC	1.79%	962.15K	18.1M	-481.08K	-33.33%
Sep 30, 2025	MARSHALL WACE, LLP	1.61%	868K	16.33M	577.47K	+198.77%
Sep 30, 2025	PARKMAN HEALTHCARE PARTNERS LLC	1.57%	843.5K	15.87M	128K	+17.89%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.52%	817.11K	15.37M	170.47K	+26.36%
Sep 30, 2025	SIREN, L.L.C.	1.47%	788.45K	14.83M	0	0
Sep 30, 2025	WOODLINE PARTNERS LP	1.12%	602.25K	11.33M	44K	+7.88%
Sep 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	1.11%	594.97K	11.19M	0	0
Sep 30, 2025	INTEGRAL HEALTH ASSET MANAGEMENT, LLC	1.07%	575K	10.82M	575K	+100.00%
Sep 30, 2025	GREAT POINT PARTNERS LLC	0.56%	300K	5.64M	0	0
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.53%	284.83K	5.36M	106.58K	+59.79%
Jun 30, 2025	COREBRIDGE FINANCIAL, INC.	0%	0	-	-8.53K	-100.00%
Jun 30, 2025	CLEARSTEAD ADVISORS, LLC	0%	163	1.79K	163	+100.00%
Jun 30, 2025	EVERSOURCE WEALTH ADVISORS, LLC	0%	309	3.39K	174	+128.89%
Jun 30, 2025	VERSANT CAPITAL MANAGEMENT, INC	0%	558	6.13K	-57	-9.27%
Jun 30, 2025	GAMMA INVESTING LLC	0%	693	7.61K	100	+16.86%
Jun 30, 2025	VR ADVISER, LLC	4.27%	2.3M	25.2M	0	0
Jun 30, 2025	PARKMAN HEALTHCARE PARTNERS LLC	1.33%	715.5K	7.86M	481.94K	+206.34%
Jun 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.06%	29.75K	326.68M	10.93K	+58.07%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.05%	24.56K	269.67M	-1.07M	-97.75%
Jun 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.01%	3.1K	34.01M	2.16K	+229.82%
Jun 30, 2025	ROYAL BANK OF CANADA	0.01%	3.09K	33K	2.26K	+271.39%
Jun 30, 2025	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0%	2.17K	23.87M	884	+68.53%
Jun 30, 2025	STERLING CAPITAL MANAGEMENT LLC	0%	941	10.33K	804	+586.86%
Jun 30, 2025	ALLWORTH FINANCIAL LP	0%	66	725	-119	-64.32%
Jun 30, 2025	TRUE WEALTH DESIGN, LLC	0%	31	341	15	+93.75%
Jun 30, 2025	TWO SIGMA INVESTMENTS, LP	0%	0	-	-21.79K	-100.00%
Jun 30, 2025	WALLEYE CAPITAL LLC	0%	0	-	-10K	-100.00%
Jun 30, 2025	RHUMBLINE ADVISERS	0.09%	48.07K	527.76K	34.74K	+260.67%
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.08%	42.26K	464.05K	21K	+98.75%
Jun 30, 2025	ALPS ADVISORS INC	0.05%	28.98K	318.16K	-10.1K	-25.85%
Jun 30, 2025	DEUTSCHE BANK AG\	0.04%	23.4K	256.97K	8.21K	+54.05%
Jun 30, 2025	WELLS FARGO & COMPANY/MN	0.04%	22.36K	245.56K	13.11K	+141.77%
Jun 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	21.69K	238.17K	10.66K	+96.58%
Jun 30, 2025	VANGUARD GROUP INC	4.04%	2.17M	23.84M	1.26M	+139.34%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	2.28%	1.23M	13.45M	-88.16K	-6.71%
Jun 30, 2025	NORGES BANK	1.8%	969.92K	10.65M	969.92K	+100.00%
Jun 30, 2025	SIREN, L.L.C.	1.47%	788.45K	8.66M	0	0
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.2%	646.64K	7.1M	235.96K	+57.46%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.03%	17.45K	192K	17.45K	+100.00%
Jun 30, 2025	STATE STREET CORP	0.9%	481.38K	5.29M	185.79K	+62.85%
Jun 30, 2025	MARSHALL WACE, LLP	0.54%	290.53K	3.19M	-14.44K	-4.73%
Jun 30, 2025	UBS GROUP AG	0.43%	232.89K	2.56M	101.34K	+77.03%
Jun 30, 2025	NORTHERN TRUST CORP	0.43%	229.3K	2.52M	91.53K	+66.44%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.33%	178.25K	1.96M	46.08K	+34.86%
Jun 30, 2025	BARCLAYS PLC	0.18%	96.99K	1.07M	72K	+288.07%
Jun 30, 2025	ENAVATE SCIENCES GP, LLC	4.57%	2.46M	27.01M	0	0
Jun 30, 2025	NUVEEN, LLC	0.14%	73.94K	811.82K	51.35K	+227.35%
Jun 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.04%	21.29K	233.76K	6.01K	+39.29%
Jun 30, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0.04%	19.08K	209.54K	8.79K	+85.35%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.15%	79.77K	875.83K	42.85K	+116.10%
Jun 30, 2025	XTX TOPCO LTD	0%	0	-	-12.73K	-100.00%
Jun 30, 2025	PHYSICIAN WEALTH ADVISORS, INC.	0%	0	-	-69	-100.00%
Jun 30, 2025	VIRTUS INVESTMENT ADVISERS, INC.	0.02%	8.13K	89.31K	8.13K	+100.00%
Jun 30, 2025	QUANTINNO CAPITAL MANAGEMENT LP	0.02%	10.61K	116.54K	-4.61K	-30.29%
Jun 30, 2025	MORGAN STANLEY	0.18%	99.31K	1.09B	47.92K	+93.24%
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.68%	365.79K	4.02M	187.81K	+105.52%
Jun 30, 2025	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	4.54%	2.44M	26.79M	144.22K	+6.28%
Jun 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	5.21%	2.8M	30.76M	0	0
Jun 30, 2025	FMR LLC	14.76%	7.94M	87.15M	681.02K	+9.39%
Jun 30, 2025	DECHENG CAPITAL LLC	6.11%	3.29M	36.07M	0	0
Jun 30, 2025	INVESCO LTD.	0.03%	16.3K	178.97K	985	+6.43%
Jun 30, 2025	JPMORGAN CHASE & CO	0.03%	16.47K	180.83K	1.28K	+8.39%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.03%	18.03K	197.98K	7.5K	+71.22%
Jun 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0%	0	-	-15K	-100.00%
Jun 30, 2025	PRINCIPAL SECURITIES, INC.	0%	0	-	-12	-100.00%
Jun 30, 2025	ALTSHULER SHAHAM LTD	6.31%	3.39M	37.27M	159.15K	+4.92%
Jun 30, 2025	ORBIMED ADVISORS LLC	10.59%	5.69M	62.52M	0	0
Jun 30, 2025	GREAT POINT PARTNERS LLC	0.56%	300K	3.29M	0	0
Jun 30, 2025	WOODLINE PARTNERS LP	1.04%	558.25K	6.13M	1.19K	+0.21%
Jun 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	1.11%	594.97K	6.53M	0	0
Jun 30, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.02%	13.19K	144.83K	13.19K	+100.00%
Jun 30, 2025	CREATIVE PLANNING	0.03%	14.03K	154.05K	14.03K	+100.00%
Jun 30, 2025	COMMONWEALTH EQUITY SERVICES, LLC	0.03%	15.53K	170K	15.53K	+100.00%
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	0.04%	22.36K	245.54K	22.36K	+100.00%
Jun 30, 2025		0.14%	73.94K	811.82K	51.35K	+227.35%
Jun 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.16%	85K	933.3K	0	0
Jun 30, 2025	VELAN CAPITAL INVESTMENT MANAGEMENT LP	0.2%	107K	1.17M	0	0
Jun 30, 2025	LYNX1 CAPITAL MANAGEMENT LP	0.41%	219.25K	2.41M	0	0
Jun 30, 2025	DEEP TRACK CAPITAL, LP	2.68%	1.44M	15.84M	-856.8K	-37.26%
Jun 30, 2025	SAMSARA BIOCAPITAL, LLC	2.68%	1.44M	15.85M	-623.92K	-30.18%
Jun 30, 2025	OMEGA FUND MANAGEMENT, LLC	3.79%	2.04M	22.36M	0	0
Jun 30, 2025	BLACKROCK, INC.	3.9%	2.1M	23.02M	910.74K	+76.81%
Jun 30, 2025	VERITION FUND MANAGEMENT LLC	0.06%	33.51K	367.89K	33.51K	+100.00%
Mar 31, 2025	RHUMBLINE ADVISERS	0.02%	13.33K	81.56K	-3.39K	-20.30%
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.03%	15K	91.8K	15K	+100.00%
Mar 31, 2025	DEUTSCHE BANK AG\	0.03%	15.19K	92.98K	341	+2.30%
Mar 31, 2025	AQR CAPITAL MANAGEMENT LLC	0.04%	18.82K	115.19K	18.82K	+100.00%
Mar 31, 2025	VELAN CAPITAL INVESTMENT MANAGEMENT LP	0.2%	107K	654.84K	107K	+100.00%
Mar 31, 2025	BLACKROCK, INC.	2.21%	1.19M	7.26M	67.97K	+6.08%
Mar 31, 2025	GREAT POINT PARTNERS LLC	0.56%	300K	1.84M	0	0
Mar 31, 2025	MARSHALL WACE, LLP	0.57%	304.96K	1.87M	14.23K	+4.89%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.77%	410.68K	2.51M	47.41K	+13.05%
Mar 31, 2025	WOODLINE PARTNERS LP	1.04%	557.06K	3.41M	30.55K	+5.80%
Mar 31, 2025	SAMSARA BIOCAPITAL, LLC	3.86%	2.07M	12.65M	-150K	-6.77%
Mar 31, 2025	VR ADVISER, LLC	4.28%	2.3M	14.05M	0	0
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.12%	61.8K	378.19K	61.8K	+100.00%
Mar 31, 2025	JPMORGAN CHASE & CO	0.03%	15.19K	92.99K	-32.6K	-68.21%
Mar 31, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	15.29K	93.54K	15.29K	+100.00%
Mar 31, 2025	INVESCO LTD.	0.03%	15.32K	93.73K	-287	-1.84%
Mar 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.16%	85K	520.2K	0	0
Mar 31, 2025	SIREN, L.L.C.	1.47%	788.45K	4.83M	-11.55K	-1.44%
Mar 31, 2025	TCG CROSSOVER MANAGEMENT, LLC	5.23%	2.8M	17.15M	0	0
Mar 31, 2025	ALTSHULER SHAHAM LTD	6.03%	3.24M	3.52M	3.24M	+100.00%
Mar 31, 2025	DECHENG CAPITAL LLC	6.13%	3.29M	20.11M	0	0
Mar 31, 2025	ORBIMED ADVISORS LLC	10.62%	5.69M	34.84M	0	0
Mar 31, 2025	FMR LLC	13.53%	7.26M	44.41M	79.67K	+1.11%
Mar 31, 2025	VANGUARD GROUP INC	1.69%	907.03K	5.55M	-8K	-0.87%
Mar 31, 2025	ALLIANCEBERNSTEIN L.P.	2.04%	1.09M	6.68M	-20.15K	-1.81%
Mar 31, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.02%	11.03K	67.53K	0	0
Mar 31, 2025	XTX TOPCO LTD	0.02%	12.73K	77.91K	12.73K	+100.00%
Mar 31, 2025	QUANTINNO CAPITAL MANAGEMENT LP	0.03%	15.23K	93.18K	15.23K	+100.00%
Mar 31, 2025	CITIGROUP INC	0.03%	18.18K	111.25K	-8.33K	-31.41%
Mar 31, 2025		0.04%	22.59K	138.23K	22.59K	+100.00%
Mar 31, 2025	UBS GROUP AG	0.25%	131.55K	805.09K	-29.96K	-18.55%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	2.45%	1.31M	8.03M	-269.7K	-17.04%
Mar 31, 2025	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	4.28%	2.3M	14.05M	0	0
Mar 31, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.33%	177.98K	1.09M	177.98K	+100.00%
Mar 31, 2025	LYNX1 CAPITAL MANAGEMENT LP	0.41%	219.25K	1.34M	-20.8K	-8.66%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.04%	21.79K	133.35K	21.79K	+100.00%
Mar 31, 2025	BARCLAYS PLC	0.05%	24.99K	153K	-2.02K	-7.49%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.06%	32.96K	201.69K	-11.54K	-25.93%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.07%	36.91K	225.9K	-1	0.00%
Mar 31, 2025	ALPS ADVISORS INC	0.07%	39.08K	239.16K	-4.26K	-9.83%
Mar 31, 2025	MORGAN STANLEY	0.1%	51.39K	314.51K	8.23K	+19.06%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.25%	132.17K	808.9K	-3.15K	-2.33%
Mar 31, 2025	NORTHERN TRUST CORP	0.26%	137.77K	843.16K	-5.95K	-4.14%
Mar 31, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	1.11%	594.97K	3.64M	-5.03K	-0.84%
Mar 31, 2025	DEEP TRACK CAPITAL, LP	4.29%	2.3M	14.07M	1.3M	+129.96%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.04%	21.26K	130.14K	21.26K	+100.00%
Mar 31, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.44%	233.56K	1.43M	233.56K	+100.00%
Mar 31, 2025	STATE STREET CORP	0.55%	295.59K	1.81M	48.4K	+19.58%
Mar 31, 2025	OMEGA FUND MANAGEMENT, LLC	3.8%	2.04M	12.46M	0	0

Insiders

Among the UPB insiders holding of 14.77% of the stake in company, SUTHERLAND EVERETT RAND, Chief Executive Officer, holds the largest shares of 72.91K. DEYKIN AARON, Chief Medical Officer, is the second largest UPB insider with ownership of 32.69K shares. GRAY MICHAEL, CFO and COO, stands third with possession of 29.65K shares of that stake.

Insiders	Designation	Shares Held
SUTHERLAND EVERETT RAND	Chief Executive Officer	72.91K
DEYKIN AARON	Chief Medical Officer	32.69K
GRAY MICHAEL	CFO and COO	29.65K
HOUGHTON ADAM	Chief Business Officer	24.3K
AMBROSE ALLISON	General Counsel	16.53K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Mar 16, 2026	GRAY MICHAEL	SALE	9.29	852	7.92K	29.65K
Mar 16, 2026	DEYKIN AARON	SALE	9.29	894	8.31K	32.69K
Mar 16, 2026	SUTHERLAND EVERETT RAND	SALE	9.29	2.09K	19.44K	72.91K
Mar 16, 2026	AMBROSE ALLISON	SALE	9.29	475	4.41K	16.53K
Mar 16, 2026	HOUGHTON ADAM	SALE	9.29	699	6.49K	24.3K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES5.01K5

NET SHARES-5.01K5

SHARES HELD176.07K5

% NET SHARES-102.85%0%

Frequently Asked Questions

Stock Outstanding Shares

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares5.75

Short Percent Of Float10.38

Shares Outstanding53.91M

Shares Float31.42M

Shares Short3.10M

Short Ratio6.78

10.38%

Short % of Float

5.75%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

14.77% Percentage of Shares held by All Insiders

87.63% Percentage of Shares held by All Institutions

102.82% Percentage of Float held by Institutions

134

Number of Institutions Holding Shares

Institutional Ownership

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	RHUMBLINE ADVISERS	0.08%	41.52K	1.13B	-7.88K	-15.96%
Dec 31, 2025	EXOME ASSET MANAGEMENT LLC	0.12%	64.85K	1.76M	12.89K	+24.80%
Dec 31, 2025	AMERICAN CENTURY COMPANIES INC	0.16%	87.76K	2.38M	16.22K	+22.67%
Dec 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.55%	298.33K	8.1M	298.33K	+100.00%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.01%	4.98K	135.1K	-1.55K	-23.76%
Dec 31, 2025	SG AMERICAS SECURITIES, LLC	0.01%	5.52K	150K	5.52K	+100.00%
Dec 31, 2025	CITIGROUP INC	0.01%	6.95K	188.67K	-35.09K	-83.47%
Dec 31, 2025	SEI INVESTMENTS CO	0.02%	8.09K	219.56K	8.09K	+100.00%
Dec 31, 2025	PROSHARE ADVISORS LLC	0.02%	8.35K	226.81K	8.35K	+100.00%
Dec 31, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	8.81K	239.08K	8.81K	+100.00%
Dec 31, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.02%	9.46K	256.73K	9	+0.10%
Dec 31, 2025	STRS OHIO	0.02%	9.8K	266.07K	9.8K	+100.00%
Dec 31, 2025	VERITION FUND MANAGEMENT LLC	0.02%	12.02K	326.34K	-34.98K	-74.43%
Dec 31, 2025	DNB ASSET MANAGEMENT AS	0.02%	12.79K	347.33K	12.79K	+100.00%
Dec 31, 2025	SIREN, L.L.C.	1.09%	588.45K	15.98M	-200K	-25.37%
Dec 31, 2025	DEUTSCHE BANK AG\	0.24%	127.82K	3.47M	101.08K	+378.05%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.53%	284.93K	7.74M	103	+0.04%
Dec 31, 2025	JENNISON ASSOCIATES LLC	0.54%	288.85K	7.84M	288.85K	+100.00%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	0.62%	333.48K	9.05M	110.27K	+49.40%
Dec 31, 2025	MARSHALL WACE, LLP	0.64%	343.79K	9.33M	-524.21K	-60.39%
Dec 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.43%	773.15K	20.99M	773.15K	+100.00%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.58%	851.91K	23.13M	34.8K	+4.26%
Dec 31, 2025	STATE STREET CORP	2.45%	1.32M	35.82M	204.65K	+18.36%
Dec 31, 2025	UBS GROUP AG	3.35%	1.81M	49.04M	1.53M	+563.40%
Dec 31, 2025	VANGUARD GROUP INC	4.43%	2.39M	64.85M	-54.11K	-2.22%
Dec 31, 2025	NORGES BANK	5.35%	2.88M	78.26M	2.88M	+100.00%
Dec 31, 2025	DECHENG CAPITAL LLC	5.83%	3.14M	85.33M	-142.22K	-4.33%
Dec 31, 2025	BLACKROCK, INC.	6.2%	3.34M	90.8M	740.8K	+28.45%
Dec 31, 2025	VIRTUS INVESTMENT ADVISERS, INC.	0.02%	9.8K	266.1K	-42	-0.43%
Dec 31, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.02%	10.15K	275.49K	-1.95K	-16.09%
Dec 31, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.02%	10.4K	282.25K	0	0
Dec 31, 2025	ALPS ADVISORS INC	0.08%	44.38K	1.2M	18.41K	+70.93%
Dec 31, 2025	Y-INTERCEPT (HONG KONG) LTD	0.09%	46.56K	1.26M	46.56K	+100.00%
Dec 31, 2025	SEVEN GRAND MANAGERS, LLC	0.09%	50K	1.36M	50K	+100.00%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	0.16%	86.38K	2.35M	30.91K	+55.72%
Dec 31, 2025	STERLING CAPITAL MANAGEMENT LLC	0%	1.92K	52.1K	-345	-15.24%
Dec 31, 2025	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0%	2.63K	71.3K	2.63K	+100.00%
Dec 31, 2025	BOXER CAPITAL MANAGEMENT, LLC	0.28%	150K	4.07M	150K	+100.00%
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	0.96%	517.26K	14.04M	477.15K	+1,189.52%
Dec 31, 2025	PARKMAN HEALTHCARE PARTNERS LLC	1.55%	834.56K	22.66M	-8.94K	-1.06%
Dec 31, 2025	AMERIPRISE FINANCIAL INC	0.1%	56.56K	1.54M	56.56K	+100.00%
Dec 31, 2025	ARTIA GLOBAL PARTNERS LP	0.13%	68.65K	1.86M	68.65K	+100.00%
Dec 31, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.14%	75.4K	2.05M	75.4K	+100.00%
Dec 31, 2025	NUVEEN, LLC	0.15%	78.57K	2.13M	8.69K	+12.43%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.16%	84.85K	2.3M	-6.67K	-7.29%
Dec 31, 2025	JPMORGAN CHASE & CO	0.2%	110.28K	2.99M	80.33K	+268.25%
Dec 31, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.21%	115.81K	3.14M	-74.44K	-39.13%
Dec 31, 2025	SUMMITTX CAPITAL, L.P.	0.22%	116.72K	3.17M	4.32K	+3.84%
Dec 31, 2025	AMERITAS INVESTMENT PARTNERS, INC.	0.01%	2.74K	74.42K	0	0
Dec 31, 2025	KLP KAPITALFORVALTNING AS	0.01%	2.9K	78.74K	2.9K	+100.00%
Dec 31, 2025	CWM, LLC	0.01%	3.36K	91K	19	+0.57%
Dec 31, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	0.92%	494.97K	13.44M	-100K	-16.81%
Dec 31, 2025	BARCLAYS PLC	0.97%	524.5K	14.24M	439.18K	+514.78%
Dec 31, 2025	MORGAN STANLEY	0.23%	122.07K	3.31M	34.53K	+39.45%
Dec 31, 2025	INVESCO LTD.	0.3%	163.19K	4.43M	146K	+849.31%
Dec 31, 2025	NORTHERN TRUST CORP	0.44%	236.8K	6.43M	-17.92K	-7.04%
Dec 31, 2025	GREAT POINT PARTNERS LLC	0.56%	300K	8.15M	0	0
Dec 31, 2025	VESTAL POINT CAPITAL, LP	1.33%	720K	19.55M	720K	+100.00%
Dec 31, 2025	SAMSARA BIOCAPITAL, LLC	1.36%	736.05K	19.98M	-226.11K	-23.50%
Dec 31, 2025	TCG CROSSOVER MANAGEMENT, LLC	1.38%	743.89K	20.2M	-1.37M	-64.86%
Dec 31, 2025	INTEGRAL HEALTH ASSET MANAGEMENT, LLC	1.39%	750K	20.36M	175K	+30.43%
Dec 31, 2025	WOODLINE PARTNERS LP	1.41%	760.25K	20.64M	158K	+26.23%
Dec 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	1.66%	894.73K	24.29M	-230.66K	-20.50%
Dec 31, 2025	VR ADVISER, LLC	2.17%	1.17M	31.75M	0	0
Dec 31, 2025	OMEGA FUND MANAGEMENT, LLC	2.46%	1.33M	36.01M	-30K	-2.21%
Dec 31, 2025	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	2.47%	1.33M	36.1M	-1.11M	-45.50%
Dec 31, 2025	ALTSHULER SHAHAM LTD	2.49%	1.34M	36.42M	-75.28K	-5.31%
Dec 31, 2025	JANUS HENDERSON GROUP PLC	2.83%	1.53M	41.42M	1.53M	+100.00%
Dec 31, 2025	ENAVATE SCIENCES GP, LLC	4.56%	2.46M	66.78M	0	0
Dec 31, 2025	ORBIMED ADVISORS LLC	10.56%	5.69M	154.58M	0	0
Dec 31, 2025	FMR LLC	13.94%	7.52M	204.12M	-568.21K	-7.03%
Dec 31, 2025	TWO SIGMA INVESTMENTS, LP	0.02%	10.5K	285.08K	0	0
Dec 31, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.02%	11.7K	317.66K	5.4K	+85.71%
Dec 31, 2025	MARINER, LLC	0.02%	11.83K	321.17K	897	+8.20%
Dec 31, 2025	CITADEL ADVISORS LLC	0.02%	13.42K	364.35M	13.42K	+100.00%
Dec 31, 2025	LEGAL & GENERAL GROUP PLC	0.03%	13.71K	372.2K	10.79K	+368.84%
Dec 31, 2025	PROFUND ADVISORS LLC	0.03%	14.58K	395.9K	14.58K	+100.00%
Dec 31, 2025	XTX TOPCO LTD	0.03%	15.09K	409.72K	15.09K	+100.00%
Dec 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.03%	16.4K	445.26K	16.4K	+100.00%
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.03%	16.5K	447.98K	16.5K	+100.00%
Dec 31, 2025		0.43%	230.65K	6.26M	230.65K	+100.00%
Dec 31, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	19.68K	534.26K	-2.01K	-9.28%
Dec 31, 2025	SWISS NATIONAL BANK	0.05%	26.6K	722.19K	26.6K	+100.00%
Dec 31, 2025	AQR CAPITAL MANAGEMENT LLC	0.06%	30.5K	828.16K	549	+1.83%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.07%	36.79K	998.96K	11.63K	+46.24%
Dec 31, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.07%	38.68K	1.05M	4.16K	+12.06%
Sep 30, 2025	EVERSOURCE WEALTH ADVISORS, LLC	0%	310	5.83K	1	+0.32%
Sep 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.11%	61.3K	1.15M	61.3K	+100.00%
Sep 30, 2025	UBS GROUP AG	0.51%	272.27K	5.12M	39.38K	+16.91%
Sep 30, 2025	CAPTION MANAGEMENT, LLC	0.13%	70K	1.32M	70K	+100.00%
Sep 30, 2025	NORTHERN TRUST CORP	0.47%	254.72K	4.79M	25.42K	+11.08%
Sep 30, 2025	SUMMITTX CAPITAL, L.P.	0.21%	112.4K	2.11M	112.4K	+100.00%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.14%	73.13K	1.38M	73.13K	+100.00%
Sep 30, 2025	NUVEEN, LLC	0.13%	69.88K	1.31M	-4.05K	-5.48%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.1%	55.47K	1.04M	37.44K	+207.65%
Sep 30, 2025	RHUMBLINE ADVISERS	0.09%	49.41K	929.32K	1.34K	+2.79%
Sep 30, 2025	VERITION FUND MANAGEMENT LLC	0.09%	47K	884.09K	13.5K	+40.28%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.07%	40.11K	754.53K	40.11K	+100.00%
Sep 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.06%	29.95K	563.43K	202	+0.68%
Sep 30, 2025	JPMORGAN CHASE & CO	0.06%	29.95K	563.3K	13.48K	+81.84%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	0.42%	223.21K	4.2M	223.21K	+100.00%
Sep 30, 2025	DIADEMA PARTNERS LP	0.37%	200K	3.76M	200K	+100.00%
Sep 30, 2025	BARCLAYS PLC	0.16%	85.32K	1.6M	-11.68K	-12.04%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.13%	71.54K	1.35M	49.18K	+219.92%
Sep 30, 2025	EXOME ASSET MANAGEMENT LLC	0.1%	51.96K	977.37K	51.96K	+100.00%
Sep 30, 2025	CITIGROUP INC	0.08%	42.04K	790.72K	30.34K	+259.44%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.06%	34.52K	649.34K	34.52K	+100.00%
Sep 30, 2025	CITADEL ADVISORS LLC	0.05%	28.3K	532.32K	28.3K	+100.00%
Sep 30, 2025	NOMURA HOLDINGS INC	0.05%	28.29K	532.14K	28.29K	+100.00%
Sep 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.35%	190.24K	3.58M	-175.55K	-47.99%
Sep 30, 2025	IKARIAN CAPITAL, LLC	0.3%	161.11K	3.03M	161.11K	+100.00%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.17%	91.52K	1.72M	11.76K	+14.74%
Sep 30, 2025	DEUTSCHE BANK AG\	0.05%	26.74K	502.92K	3.33K	+14.25%
Sep 30, 2025	ALPS ADVISORS INC	0.05%	25.96K	488.35K	-3.01K	-10.40%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.05%	25.16K	473.26K	2.8K	+12.50%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	21.69K	408.01K	0	0
Sep 30, 2025	JANE STREET GROUP, LLC	0.04%	20.5K	385.61M	20.5K	+100.00%
Sep 30, 2025	SIG BROKERAGE, LP	0.04%	20K	376.2K	20K	+100.00%
Sep 30, 2025	ALLIANCEBERNSTEIN L.P.	0.04%	19.85K	373.38K	-4.71K	-19.18%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.03%	18.5K	349K	1.05K	+6.04%
Sep 30, 2025	INVESCO LTD.	0.03%	17.19K	323.34K	890	+5.46%
Sep 30, 2025	COMMONWEALTH EQUITY SERVICES, LLC	0.03%	15.5K	292K	-23	-0.15%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.02%	10.4K	195.55K	-10.89K	-51.17%
Sep 30, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.02%	9.45K	177.7K	1.61K	+20.61%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.01%	6.53K	122.77K	3.43K	+110.75%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.01%	6.3K	118.5K	1.6K	+34.04%
Sep 30, 2025	CWM, LLC	0.01%	3.34K	63K	29	+0.88%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.01%	3.03K	57.07K	2.89K	+1,963.95%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.01%	2.92K	55K	-250	-7.88%
Sep 30, 2025	AMERITAS INVESTMENT PARTNERS, INC.	0.01%	2.74K	51.56K	-817	-22.96%
Sep 30, 2025	STERLING CAPITAL MANAGEMENT LLC	0%	2.26K	42.59K	1.32K	+140.60%
Sep 30, 2025	GROUP ONE TRADING, L.P.	0%	1.31K	24.55M	1.31K	+100.00%
Sep 30, 2025	ASTER CAPITAL MANAGEMENT (DIFC) LTD	0%	1.14K	21.46K	1.14K	+100.00%
Sep 30, 2025	GAMMA INVESTING LLC	0%	890	16.74K	197	+28.43%
Sep 30, 2025	AMALGAMATED BANK	0%	594	11K	0	0
Sep 30, 2025	VERSANT CAPITAL MANAGEMENT, INC	0%	548	10.31K	-10	-1.79%
Sep 30, 2025	US BANCORP \DE\	0%	531	9.99K	-128	-19.42%
Sep 30, 2025	GLOBAL RETIREMENT PARTNERS, LLC	0%	332	6.25K	332	+100.00%
Sep 30, 2025	CLEARSTEAD ADVISORS, LLC	0%	163	3.07K	0	0
Sep 30, 2025	PNC FINANCIAL SERVICES GROUP, INC.	0%	130	2.45K	130	+100.00%
Sep 30, 2025	J.SAFRA ASSET MANAGEMENT CORP	0%	128	2.41K	128	+100.00%
Sep 30, 2025	NISA INVESTMENT ADVISORS, LLC	0%	96	1.81K	0	0
Sep 30, 2025	N.E.W. ADVISORY SERVICES LLC	0%	60	1.13K	60	+100.00%
Sep 30, 2025	SIGNATUREFD, LLC	0%	51	959	2	+4.08%
Sep 30, 2025	PARALLEL ADVISORS, LLC	0%	2	38	0	0
Sep 30, 2025	STRS OHIO	0%	0	-	-1.8K	-100.00%
Sep 30, 2025	LYNX1 CAPITAL MANAGEMENT LP	0%	0	-	-219.25K	-100.00%
Sep 30, 2025	TRUE WEALTH DESIGN, LLC	0%	0	-	-31	-100.00%
Sep 30, 2025	MORGAN STANLEY	0.16%	87.54K	1.65M	-11.77K	-11.86%
Sep 30, 2025	FMR LLC	15.04%	8.09M	152.11M	149.53K	+1.88%
Sep 30, 2025	ORBIMED ADVISORS LLC	10.59%	5.69M	107.1M	0	0
Sep 30, 2025	DECHENG CAPITAL LLC	6.11%	3.29M	61.8M	0	0
Sep 30, 2025	BLACKROCK, INC.	4.84%	2.6M	48.98M	507.2K	+24.19%
Sep 30, 2025	ENAVATE SCIENCES GP, LLC	4.57%	2.46M	46.27M	0	0
Sep 30, 2025	VANGUARD GROUP INC	4.54%	2.44M	45.94M	271.72K	+12.52%
Sep 30, 2025	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	4.54%	2.44M	45.89M	0	0
Sep 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	3.94%	2.12M	39.82M	-684.66K	-24.44%
Sep 30, 2025	ALTSHULER SHAHAM LTD	2.63%	1.42M	26.65M	-1.98M	-58.26%
Sep 30, 2025	OMEGA FUND MANAGEMENT, LLC	2.52%	1.36M	25.51M	-680K	-33.39%
Sep 30, 2025	VR ADVISER, LLC	2.17%	1.17M	21.99M	-1.13M	-49.06%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	2.09%	1.13M	21.17M	-99.9K	-8.15%
Sep 30, 2025	STATE STREET CORP	2.07%	1.11M	20.97M	633.21K	+131.54%
Sep 30, 2025	SAMSARA BIOCAPITAL, LLC	1.79%	962.15K	18.1M	-481.08K	-33.33%
Sep 30, 2025	MARSHALL WACE, LLP	1.61%	868K	16.33M	577.47K	+198.77%
Sep 30, 2025	PARKMAN HEALTHCARE PARTNERS LLC	1.57%	843.5K	15.87M	128K	+17.89%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.52%	817.11K	15.37M	170.47K	+26.36%
Sep 30, 2025	SIREN, L.L.C.	1.47%	788.45K	14.83M	0	0
Sep 30, 2025	WOODLINE PARTNERS LP	1.12%	602.25K	11.33M	44K	+7.88%
Sep 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	1.11%	594.97K	11.19M	0	0
Sep 30, 2025	INTEGRAL HEALTH ASSET MANAGEMENT, LLC	1.07%	575K	10.82M	575K	+100.00%
Sep 30, 2025	GREAT POINT PARTNERS LLC	0.56%	300K	5.64M	0	0
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.53%	284.83K	5.36M	106.58K	+59.79%
Jun 30, 2025	COREBRIDGE FINANCIAL, INC.	0%	0	-	-8.53K	-100.00%
Jun 30, 2025	CLEARSTEAD ADVISORS, LLC	0%	163	1.79K	163	+100.00%
Jun 30, 2025	EVERSOURCE WEALTH ADVISORS, LLC	0%	309	3.39K	174	+128.89%
Jun 30, 2025	VERSANT CAPITAL MANAGEMENT, INC	0%	558	6.13K	-57	-9.27%
Jun 30, 2025	GAMMA INVESTING LLC	0%	693	7.61K	100	+16.86%
Jun 30, 2025	VR ADVISER, LLC	4.27%	2.3M	25.2M	0	0
Jun 30, 2025	PARKMAN HEALTHCARE PARTNERS LLC	1.33%	715.5K	7.86M	481.94K	+206.34%
Jun 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.06%	29.75K	326.68M	10.93K	+58.07%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.05%	24.56K	269.67M	-1.07M	-97.75%
Jun 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.01%	3.1K	34.01M	2.16K	+229.82%
Jun 30, 2025	ROYAL BANK OF CANADA	0.01%	3.09K	33K	2.26K	+271.39%
Jun 30, 2025	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0%	2.17K	23.87M	884	+68.53%
Jun 30, 2025	STERLING CAPITAL MANAGEMENT LLC	0%	941	10.33K	804	+586.86%
Jun 30, 2025	ALLWORTH FINANCIAL LP	0%	66	725	-119	-64.32%
Jun 30, 2025	TRUE WEALTH DESIGN, LLC	0%	31	341	15	+93.75%
Jun 30, 2025	TWO SIGMA INVESTMENTS, LP	0%	0	-	-21.79K	-100.00%
Jun 30, 2025	WALLEYE CAPITAL LLC	0%	0	-	-10K	-100.00%
Jun 30, 2025	RHUMBLINE ADVISERS	0.09%	48.07K	527.76K	34.74K	+260.67%
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.08%	42.26K	464.05K	21K	+98.75%
Jun 30, 2025	ALPS ADVISORS INC	0.05%	28.98K	318.16K	-10.1K	-25.85%
Jun 30, 2025	DEUTSCHE BANK AG\	0.04%	23.4K	256.97K	8.21K	+54.05%
Jun 30, 2025	WELLS FARGO & COMPANY/MN	0.04%	22.36K	245.56K	13.11K	+141.77%
Jun 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	21.69K	238.17K	10.66K	+96.58%
Jun 30, 2025	VANGUARD GROUP INC	4.04%	2.17M	23.84M	1.26M	+139.34%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	2.28%	1.23M	13.45M	-88.16K	-6.71%
Jun 30, 2025	NORGES BANK	1.8%	969.92K	10.65M	969.92K	+100.00%
Jun 30, 2025	SIREN, L.L.C.	1.47%	788.45K	8.66M	0	0
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.2%	646.64K	7.1M	235.96K	+57.46%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.03%	17.45K	192K	17.45K	+100.00%
Jun 30, 2025	STATE STREET CORP	0.9%	481.38K	5.29M	185.79K	+62.85%
Jun 30, 2025	MARSHALL WACE, LLP	0.54%	290.53K	3.19M	-14.44K	-4.73%
Jun 30, 2025	UBS GROUP AG	0.43%	232.89K	2.56M	101.34K	+77.03%
Jun 30, 2025	NORTHERN TRUST CORP	0.43%	229.3K	2.52M	91.53K	+66.44%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.33%	178.25K	1.96M	46.08K	+34.86%
Jun 30, 2025	BARCLAYS PLC	0.18%	96.99K	1.07M	72K	+288.07%
Jun 30, 2025	ENAVATE SCIENCES GP, LLC	4.57%	2.46M	27.01M	0	0
Jun 30, 2025	NUVEEN, LLC	0.14%	73.94K	811.82K	51.35K	+227.35%
Jun 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.04%	21.29K	233.76K	6.01K	+39.29%
Jun 30, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0.04%	19.08K	209.54K	8.79K	+85.35%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.15%	79.77K	875.83K	42.85K	+116.10%
Jun 30, 2025	XTX TOPCO LTD	0%	0	-	-12.73K	-100.00%
Jun 30, 2025	PHYSICIAN WEALTH ADVISORS, INC.	0%	0	-	-69	-100.00%
Jun 30, 2025	VIRTUS INVESTMENT ADVISERS, INC.	0.02%	8.13K	89.31K	8.13K	+100.00%
Jun 30, 2025	QUANTINNO CAPITAL MANAGEMENT LP	0.02%	10.61K	116.54K	-4.61K	-30.29%
Jun 30, 2025	MORGAN STANLEY	0.18%	99.31K	1.09B	47.92K	+93.24%
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.68%	365.79K	4.02M	187.81K	+105.52%
Jun 30, 2025	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	4.54%	2.44M	26.79M	144.22K	+6.28%
Jun 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	5.21%	2.8M	30.76M	0	0
Jun 30, 2025	FMR LLC	14.76%	7.94M	87.15M	681.02K	+9.39%
Jun 30, 2025	DECHENG CAPITAL LLC	6.11%	3.29M	36.07M	0	0
Jun 30, 2025	INVESCO LTD.	0.03%	16.3K	178.97K	985	+6.43%
Jun 30, 2025	JPMORGAN CHASE & CO	0.03%	16.47K	180.83K	1.28K	+8.39%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.03%	18.03K	197.98K	7.5K	+71.22%
Jun 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0%	0	-	-15K	-100.00%
Jun 30, 2025	PRINCIPAL SECURITIES, INC.	0%	0	-	-12	-100.00%
Jun 30, 2025	ALTSHULER SHAHAM LTD	6.31%	3.39M	37.27M	159.15K	+4.92%
Jun 30, 2025	ORBIMED ADVISORS LLC	10.59%	5.69M	62.52M	0	0
Jun 30, 2025	GREAT POINT PARTNERS LLC	0.56%	300K	3.29M	0	0
Jun 30, 2025	WOODLINE PARTNERS LP	1.04%	558.25K	6.13M	1.19K	+0.21%
Jun 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	1.11%	594.97K	6.53M	0	0
Jun 30, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.02%	13.19K	144.83K	13.19K	+100.00%
Jun 30, 2025	CREATIVE PLANNING	0.03%	14.03K	154.05K	14.03K	+100.00%
Jun 30, 2025	COMMONWEALTH EQUITY SERVICES, LLC	0.03%	15.53K	170K	15.53K	+100.00%
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	0.04%	22.36K	245.54K	22.36K	+100.00%
Jun 30, 2025		0.14%	73.94K	811.82K	51.35K	+227.35%
Jun 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.16%	85K	933.3K	0	0
Jun 30, 2025	VELAN CAPITAL INVESTMENT MANAGEMENT LP	0.2%	107K	1.17M	0	0
Jun 30, 2025	LYNX1 CAPITAL MANAGEMENT LP	0.41%	219.25K	2.41M	0	0
Jun 30, 2025	DEEP TRACK CAPITAL, LP	2.68%	1.44M	15.84M	-856.8K	-37.26%
Jun 30, 2025	SAMSARA BIOCAPITAL, LLC	2.68%	1.44M	15.85M	-623.92K	-30.18%
Jun 30, 2025	OMEGA FUND MANAGEMENT, LLC	3.79%	2.04M	22.36M	0	0
Jun 30, 2025	BLACKROCK, INC.	3.9%	2.1M	23.02M	910.74K	+76.81%
Jun 30, 2025	VERITION FUND MANAGEMENT LLC	0.06%	33.51K	367.89K	33.51K	+100.00%
Mar 31, 2025	RHUMBLINE ADVISERS	0.02%	13.33K	81.56K	-3.39K	-20.30%
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.03%	15K	91.8K	15K	+100.00%
Mar 31, 2025	DEUTSCHE BANK AG\	0.03%	15.19K	92.98K	341	+2.30%
Mar 31, 2025	AQR CAPITAL MANAGEMENT LLC	0.04%	18.82K	115.19K	18.82K	+100.00%
Mar 31, 2025	VELAN CAPITAL INVESTMENT MANAGEMENT LP	0.2%	107K	654.84K	107K	+100.00%
Mar 31, 2025	BLACKROCK, INC.	2.21%	1.19M	7.26M	67.97K	+6.08%
Mar 31, 2025	GREAT POINT PARTNERS LLC	0.56%	300K	1.84M	0	0
Mar 31, 2025	MARSHALL WACE, LLP	0.57%	304.96K	1.87M	14.23K	+4.89%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.77%	410.68K	2.51M	47.41K	+13.05%
Mar 31, 2025	WOODLINE PARTNERS LP	1.04%	557.06K	3.41M	30.55K	+5.80%
Mar 31, 2025	SAMSARA BIOCAPITAL, LLC	3.86%	2.07M	12.65M	-150K	-6.77%
Mar 31, 2025	VR ADVISER, LLC	4.28%	2.3M	14.05M	0	0
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.12%	61.8K	378.19K	61.8K	+100.00%
Mar 31, 2025	JPMORGAN CHASE & CO	0.03%	15.19K	92.99K	-32.6K	-68.21%
Mar 31, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	15.29K	93.54K	15.29K	+100.00%
Mar 31, 2025	INVESCO LTD.	0.03%	15.32K	93.73K	-287	-1.84%
Mar 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.16%	85K	520.2K	0	0
Mar 31, 2025	SIREN, L.L.C.	1.47%	788.45K	4.83M	-11.55K	-1.44%
Mar 31, 2025	TCG CROSSOVER MANAGEMENT, LLC	5.23%	2.8M	17.15M	0	0
Mar 31, 2025	ALTSHULER SHAHAM LTD	6.03%	3.24M	3.52M	3.24M	+100.00%
Mar 31, 2025	DECHENG CAPITAL LLC	6.13%	3.29M	20.11M	0	0
Mar 31, 2025	ORBIMED ADVISORS LLC	10.62%	5.69M	34.84M	0	0
Mar 31, 2025	FMR LLC	13.53%	7.26M	44.41M	79.67K	+1.11%
Mar 31, 2025	VANGUARD GROUP INC	1.69%	907.03K	5.55M	-8K	-0.87%
Mar 31, 2025	ALLIANCEBERNSTEIN L.P.	2.04%	1.09M	6.68M	-20.15K	-1.81%
Mar 31, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.02%	11.03K	67.53K	0	0
Mar 31, 2025	XTX TOPCO LTD	0.02%	12.73K	77.91K	12.73K	+100.00%
Mar 31, 2025	QUANTINNO CAPITAL MANAGEMENT LP	0.03%	15.23K	93.18K	15.23K	+100.00%
Mar 31, 2025	CITIGROUP INC	0.03%	18.18K	111.25K	-8.33K	-31.41%
Mar 31, 2025		0.04%	22.59K	138.23K	22.59K	+100.00%
Mar 31, 2025	UBS GROUP AG	0.25%	131.55K	805.09K	-29.96K	-18.55%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	2.45%	1.31M	8.03M	-269.7K	-17.04%
Mar 31, 2025	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	4.28%	2.3M	14.05M	0	0
Mar 31, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.33%	177.98K	1.09M	177.98K	+100.00%
Mar 31, 2025	LYNX1 CAPITAL MANAGEMENT LP	0.41%	219.25K	1.34M	-20.8K	-8.66%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.04%	21.79K	133.35K	21.79K	+100.00%
Mar 31, 2025	BARCLAYS PLC	0.05%	24.99K	153K	-2.02K	-7.49%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.06%	32.96K	201.69K	-11.54K	-25.93%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.07%	36.91K	225.9K	-1	0.00%
Mar 31, 2025	ALPS ADVISORS INC	0.07%	39.08K	239.16K	-4.26K	-9.83%
Mar 31, 2025	MORGAN STANLEY	0.1%	51.39K	314.51K	8.23K	+19.06%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.25%	132.17K	808.9K	-3.15K	-2.33%
Mar 31, 2025	NORTHERN TRUST CORP	0.26%	137.77K	843.16K	-5.95K	-4.14%
Mar 31, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	1.11%	594.97K	3.64M	-5.03K	-0.84%
Mar 31, 2025	DEEP TRACK CAPITAL, LP	4.29%	2.3M	14.07M	1.3M	+129.96%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.04%	21.26K	130.14K	21.26K	+100.00%
Mar 31, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.44%	233.56K	1.43M	233.56K	+100.00%
Mar 31, 2025	STATE STREET CORP	0.55%	295.59K	1.81M	48.4K	+19.58%
Mar 31, 2025	OMEGA FUND MANAGEMENT, LLC	3.8%	2.04M	12.46M	0	0

Insiders

Insiders	Designation	Shares Held
SUTHERLAND EVERETT RAND	Chief Executive Officer	72.91K
DEYKIN AARON	Chief Medical Officer	32.69K
GRAY MICHAEL	CFO and COO	29.65K
HOUGHTON ADAM	Chief Business Officer	24.3K
AMBROSE ALLISON	General Counsel	16.53K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Mar 16, 2026	GRAY MICHAEL	SALE	9.29	852	7.92K	29.65K
Mar 16, 2026	DEYKIN AARON	SALE	9.29	894	8.31K	32.69K
Mar 16, 2026	SUTHERLAND EVERETT RAND	SALE	9.29	2.09K	19.44K	72.91K
Mar 16, 2026	AMBROSE ALLISON	SALE	9.29	475	4.41K	16.53K
Mar 16, 2026	HOUGHTON ADAM	SALE	9.29	699	6.49K	24.3K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES5.01K5

NET SHARES-5.01K5

SHARES HELD176.07K5

% NET SHARES-102.85%0%

UPB Stock Ownership Breakdown

Upstream Bio

Stock Outstanding Shares

Market Insider

Institutional Ownership

Insiders

Buying/Selling by Insiders

Insider Transaction Summary (6 Months)

Frequently Asked Questions

Stock Outstanding Shares

Market Insider

Institutional Ownership

Insiders

Buying/Selling by Insiders

Insider Transaction Summary (6 Months)

Frequently Asked Questions