How many institutions own SYRE stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own SYRE shares is 209, representing 84.39% of the company's common stock.

Who are the major shareholders selling Spyre Therapeutics, Inc. stock?

EMERALD ADVISERS, LLC, in the last quarter, reduced its stake in SYRE by -3.03% restricting it's holding to 548.71 thousand shares of worth nearly $9.20M. PRICE T ROWE ASSOCIATES INC /MD/ also lessened -33.3% of the SYRE shares from its portfolio, reducing its holding to 620.62 thousand shares of worth $10.40M. NUVEEN, LLC also shunned SYRE shares holding by -28.8% last quarter which brought its holding to 96.17 thousand shares worth $1.61M.

Investors who are buying SYRE stock?

As per its latest 13F filing, AFFINITY ASSET ADVISORS, LLC increased its stake in SYRE by 133.95% in the last quarter. The institutional holder raised its holding to 1.42 million shares having worth more than $23.79M. POLAR CAPITAL HOLDINGS PLC also added 5.88% more shares of SYRE to its portfolio, raising its holding to 788.79 thousand shares of worth $13.22M. HIGHVISTA STRATEGIES LLC also increased its SYRE shares holding by 91.26% which brought its holding to 215.75 thousand shares worth $3.62M.

SYRE's major insiders: who are they?

The insider with the most stakes in SYRE is Turtle Cameron , Chief Executive Officer at the company. Additionally, SYRE stock is highly held by Chief Financial Officer Burrows Scott L and director Albers Jeffrey W. among others.

Did an insider recently sell SYRE stock?

Company executives, directors, and other insiders own 6.7% percent of Spyre Therapeutics, Inc.'s stock. Within the last six months, there have been 4 transaction(s) in which SYRE insiders have sold stock, totaling 39.38K shares. Insiders that have sold shares include TURTLE CAMERON, BURROWS SCOTT L, and ALBERS JEFFREY W..

Which insider recently purchased SYRE stock?

There have been 0 transaction(s) during the past 6-months in which Spyre Therapeutics, Inc. insiders have bought stock, totalling 0 shares

How much of SYRE does insiders own?

Around 2.16M Spyre Therapeutics, Inc. shares are held by insiders, which represents about 6.7% of SYRE stock.

Who is the insider with the largest stake?

SYRE Chief Executive Officer, Turtle Cameron holds the largest portfolio of the company's shares. SYRE shares owned by Turtle total nearly 671.91 thousand.

Which institution holds the most shares in SYRE?

AFFINITY ASSET ADVISORS, LLC is the largest institutional owner in SYRE which holds 1.42 million shares worth $23.79M or 1.89% of the total SYRE shares outstanding followed by POLAR CAPITAL HOLDINGS PLC with ownership of 788.79 thousand shares representing 1.05% of the SYRE ownership. HIGHVISTA STRATEGIES LLC is the third largest stakeholder with 215.75 thousand shares or 0.29% of the ownership worth more than $3.62M.

Is Spyre Therapeutics, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the SYRE is concerned, it is a stock which is optionable.

Is there a short position on SYRE's shares?

Number of SYRE shares short is 13.19M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding SYRE shares are there?

As of today, 60.40M shares of SYRE are outstanding.

Is there many float in SYRE stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, SYRE has 46.75M shares in float.

SYRE short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for SYRE is 25.91.

Spyre Therapeutics (SYRE) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares21.83

Short Percent Of Float28.03

Shares Outstanding60.40M

Shares Float46.75M

Shares Short13.19M

Short Ratio25.91

28.03%

Short % of Float

21.83%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

6.7% Percentage of Shares held by All Insiders

84.39% Percentage of Shares held by All Institutions

90.45% Percentage of Float held by Institutions

209

Number of Institutions Holding Shares

Institutional Ownership

About 84.39% of SYRE shares are held by financial institutions. AFFINITY ASSET ADVISORS, LLC is the top corporate investor, holding 1.42M shares valued at $23.79M. A 1.89% stake in Spyre Therapeutics, Inc. is owned by the company. POLAR CAPITAL HOLDINGS PLC owns 788.79K shares valued at $13.22M, which translates its holding of 1.05% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	AFFINITY ASSET ADVISORS, LLC	1.89%	1.42M	23.79M	812.62K	+133.95%
Sep 30, 2025	POLAR CAPITAL HOLDINGS PLC	1.05%	788.79K	13.22M	43.79K	+5.88%
Sep 30, 2025	HIGHVISTA STRATEGIES LLC	0.29%	215.75K	3.62M	102.94K	+91.26%
Sep 30, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.27%	200.75K	3.36M	200.75K	+100.00%
Sep 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.82%	613.67K	10.29M	0	0
Sep 30, 2025	EMERALD ADVISERS, LLC	0.73%	548.71K	9.2M	-17.15K	-3.03%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.83%	620.62K	10.4M	-309.86K	-33.30%
Sep 30, 2025	B GROUP, INC.	0.16%	100K	1.68M	20K	+25.00%
Sep 30, 2025	NUVEEN, LLC	0.16%	96.17K	1.61M	-38.9K	-28.80%
Sep 30, 2025	JANE STREET GROUP, LLC	0.16%	96.06K	1.61B	96.06K	+100.00%
Sep 30, 2025	CAPTION MANAGEMENT, LLC	0.14%	85.2K	1.43M	15.2K	+21.71%
Sep 30, 2025	JEFFERIES FINANCIAL GROUP INC.	1.85%	1.39M	23.28M	0	0
Sep 30, 2025	PERCEPTIVE ADVISORS LLC	1.64%	1.23M	20.61M	-300K	-19.62%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.64%	1.23M	20.54M	-2.08K	-0.17%
Sep 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	1.47%	1.1M	18.45M	1.1M	+100.00%
Sep 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.38%	1.04M	17.37M	-43.23K	-4.00%
Sep 30, 2025	BAKER BROS. ADVISORS LP	1.33%	1M	16.76M	373.3K	+59.57%
Sep 30, 2025	FRANKLIN RESOURCES INC	1.06%	795.28K	13.33M	0	0
Sep 30, 2025	BLACKSTONE INC.	0.67%	501K	8.4M	11.75K	+2.40%
Sep 30, 2025	NORTHERN TRUST CORP	0.59%	442.04K	7.41M	5.09K	+1.16%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.57%	425.35K	7.13M	6.84K	+1.63%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.54%	408.2K	6.84M	408.2K	+100.00%
Sep 30, 2025	CANDRIAM S.C.A.	0.54%	404.36K	6.78M	158.33K	+64.35%
Sep 30, 2025	UBS GROUP AG	0.51%	385.59K	6.46M	-77.27K	-16.69%
Sep 30, 2025	SIREN, L.L.C.	0.49%	368.6K	6.18M	0	0
Sep 30, 2025	GOLDMAN SACHS GROUP INC	0.44%	329.53K	5.52M	-193.88K	-37.04%
Sep 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.44%	326.08K	5.47M	-28.04K	-7.92%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.42%	315.91K	5.29M	92.59K	+41.46%
Sep 30, 2025	CAPITAL WORLD INVESTORS	0.27%	200.17K	3.35M	-150.6K	-42.93%
Sep 30, 2025	BARCLAYS PLC	0.22%	168.33K	2.82M	-48.32K	-22.30%
Sep 30, 2025	ARMISTICE CAPITAL, LLC	0.21%	156K	2.61M	-16K	-9.30%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.18%	135.96K	2.28M	3.81K	+2.88%
Sep 30, 2025	WOODLINE PARTNERS LP	0.18%	131.88K	2.21M	-333.28K	-71.65%
Sep 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.15%	110.46K	1.85M	1.17K	+1.07%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.46%	344.8K	5.78M	-51.55K	-13.01%
Sep 30, 2025	JPMORGAN CHASE & CO	0.45%	275.98K	4.63M	228.71K	+483.73%
Sep 30, 2025	MORGAN STANLEY	0.45%	334.72K	5.61M	-336.32K	-50.12%
Sep 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.14%	107.74K	1.76M	-21.82K	-16.84%
Sep 30, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.41%	308.21K	5.17M	-21.22K	-6.44%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.14%	84.22K	1.41M	84.22K	+100.00%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.12%	72.37K	1.21M	-41.6K	-36.50%
Sep 30, 2025	RHUMBLINE ADVISERS	0.12%	70.91K	1.19M	-2.25K	-3.08%
Sep 30, 2025	SWISS NATIONAL BANK	0.12%	70.2K	1.18M	1.6K	+2.33%
Sep 30, 2025	QUEST PARTNERS LLC	0.11%	66.16K	1.11M	61.99K	+1,485.12%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.1%	59.67K	1M	8.71K	+17.09%
Sep 30, 2025	F/M INVESTMENTS LLC	0.09%	54.89K	920.01K	2.35K	+4.47%
Sep 30, 2025	INVESCO LTD.	0.08%	50.7K	849.77K	16.02K	+46.20%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.08%	46.84K	785.05K	11.87K	+33.95%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.06%	39.32K	658.99K	4.91K	+14.27%
Sep 30, 2025	DEUTSCHE BANK AG\	0.06%	38.54K	645.98K	4.61K	+13.57%
Sep 30, 2025	CITIGROUP INC	0.05%	32.9K	551.34K	3.64K	+12.42%
Sep 30, 2025	DLD ASSET MANAGEMENT, LP	0.05%	30K	502.8K	30K	+100.00%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.05%	29.92K	501.43K	0	0
Sep 30, 2025	JUMP FINANCIAL, LLC	0.04%	27.1K	454.2K	27.1K	+100.00%
Sep 30, 2025	TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY	0.04%	25.8K	432K	0	0
Sep 30, 2025	OPTIMIZE FINANCIAL INC	0.04%	24.97K	418.45K	24.97K	+100.00%
Sep 30, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.04%	22.14K	371K	0	0
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	20.36K	341.23K	-4.59K	-18.38%
Sep 30, 2025	QUADRATURE CAPITAL LTD	0.03%	19.37K	324.77K	19.37K	+100.00%
Sep 30, 2025	VIRGINIA RETIREMENT SYSTEMS ET AL	0.03%	18.5K	310.06K	18.5K	+100.00%
Sep 30, 2025	GLOBAL ENDOWMENT MANAGEMENT, LP	0.03%	18.18K	304.76K	0	0
Sep 30, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.03%	18.17K	304.56K	18.17K	+100.00%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.03%	16.57K	277.63K	0	0
Sep 30, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.02%	13.81K	231.44K	2.28K	+19.82%
Sep 30, 2025	PROFUND ADVISORS LLC	0.02%	13.22K	221.62K	2.18K	+19.74%
Sep 30, 2025	ARIZONA STATE RETIREMENT SYSTEM	0.02%	10.69K	179.22K	181	+1.72%
Sep 30, 2025	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.35%	264.32K	4.43M	-14.6K	-5.24%
Sep 30, 2025	MERCER GLOBAL ADVISORS INC /ADV	0.18%	106.66K	1.79M	522	+0.49%
Sep 30, 2025	FMR LLC	12.09%	9.06M	151.85M	7.11K	+0.08%
Sep 30, 2025	FAIRMOUNT FUNDS MANAGEMENT LLC	5.36%	4.02M	67.34M	0	0
Sep 30, 2025	BLACKROCK, INC.	5.32%	3.98M	66.75M	-24.55K	-0.61%
Sep 30, 2025	RTW INVESTMENTS, LP	4.83%	3.62M	60.7M	0	0
Sep 30, 2025	TANG CAPITAL MANAGEMENT LLC	4.27%	3.2M	53.63M	0	0
Sep 30, 2025	VANGUARD GROUP INC	4.07%	3.05M	51.13M	-15.86K	-0.52%
Sep 30, 2025	VR ADVISER, LLC	3.58%	2.69M	45.01M	0	0
Sep 30, 2025	BRAIDWELL LP	3.44%	2.58M	43.21M	0	0
Sep 30, 2025	CAPITAL INTERNATIONAL INVESTORS	3.19%	2.39M	40.1M	0	0
Sep 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	2.75%	2.06M	34.53M	-25.22K	-1.21%
Sep 30, 2025	COMMODORE CAPITAL LP	2.65%	1.99M	33.32M	0	0
Sep 30, 2025	STATE STREET CORP	2.38%	1.79M	29.92M	189.92K	+11.90%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	2.19%	1.64M	27.49M	126.83K	+8.38%
Sep 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	1.96%	1.47M	24.59M	-403.18K	-21.56%
Jun 30, 2025	TD ASSET MANAGEMENT INC	0.19%	113.97K	1.71M	91.6K	+409.51%
Jun 30, 2025	HIGHVISTA STRATEGIES LLC	0.19%	112.81K	1.69M	17.65K	+18.54%
Jun 30, 2025	NUVEEN, LLC	0.22%	135.07K	2.02M	-5.06K	-3.61%
Jun 30, 2025	FAIRMOUNT FUNDS MANAGEMENT LLC	6.62%	4.02M	60.15M	0	0
Jun 30, 2025	BLACKROCK, INC.	6.6%	4.01M	59.99M	434.62K	+12.17%
Jun 30, 2025	CAPITAL INTERNATIONAL INVESTORS	3.94%	2.39M	35.82M	0	0
Jun 30, 2025	FMR LLC	14.92%	9.05M	135.52M	14.48K	+0.16%
Jun 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	3.44%	2.09M	31.22M	-631.72K	-23.25%
Jun 30, 2025	COMMODORE CAPITAL LP	3.28%	1.99M	29.76M	0	0
Jun 30, 2025	STATE STREET CORP	2.63%	1.6M	23.88M	-101.82K	-6.00%
Jun 30, 2025	AFFINITY ASSET ADVISORS, LLC	1%	606.68K	9.08M	125K	+25.95%
Jun 30, 2025	BLACKSTONE INC.	0.81%	489.25K	7.32M	0	0
Jun 30, 2025	UBS GROUP AG	0.76%	462.86K	6.93M	-89.38K	-16.18%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.02%	1.23M	18.37M	167.67K	+15.82%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	1.53%	930.48K	13.93M	681.94K	+274.38%
Jun 30, 2025	FRANKLIN RESOURCES INC	1.31%	795.28K	11.91M	34.65K	+4.56%
Jun 30, 2025	MORGAN STANLEY	1.11%	671.04K	10.05M	335.58K	+100.03%
Jun 30, 2025	BAKER BROS. ADVISORS LP	1.03%	626.7K	9.38M	626.7K	+100.00%
Jun 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.01%	613.67K	9.19M	163.67K	+36.37%
Jun 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.58%	354.12K	5.3M	102.27K	+40.61%
Jun 30, 2025	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.46%	278.92K	4.18M	21.49K	+8.35%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.22%	132.15K	1.98M	17.91K	+15.68%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.69%	418.5K	6.26M	35.87K	+9.37%
Jun 30, 2025	JEFFERIES FINANCIAL GROUP INC.	2.29%	1.39M	20.79M	140K	+11.21%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.65%	396.35K	5.93M	-30.72K	-7.19%
Jun 30, 2025	CANDRIAM S.C.A.	0.41%	246.03K	3.68M	0	0
Jun 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.37%	223.32K	3.34M	167.49K	+299.98%
Jun 30, 2025	DEEP TRACK CAPITAL, LP	0.36%	219.02K	3.28M	0	0
Jun 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	3.08%	1.87M	28M	-256.76K	-12.07%
Jun 30, 2025	PERCEPTIVE ADVISORS LLC	2.52%	1.53M	22.9M	-783.83K	-33.88%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	2.49%	1.51M	22.66M	-80.2K	-5.03%
Jun 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.78%	1.08M	16.16M	10.55K	+0.99%
Jun 30, 2025	RTW INVESTMENTS, LP	5.97%	3.62M	54.22M	0	0
Jun 30, 2025	TANG CAPITAL MANAGEMENT LLC	5.27%	3.2M	47.9M	1.15M	+56.10%
Jun 30, 2025	VANGUARD GROUP INC	5.05%	3.07M	45.91M	168.32K	+5.81%
Jun 30, 2025	VR ADVISER, LLC	4.42%	2.69M	40.2M	0	0
Jun 30, 2025	BRAIDWELL LP	4.25%	2.58M	38.6M	0	0
Jun 30, 2025	POLAR CAPITAL HOLDINGS PLC	1.23%	745K	11.15M	-80K	-9.70%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.01%	610.2K	9.13M	-193K	-24.03%
Jun 30, 2025	EMERALD ADVISERS, LLC	0.93%	565.86K	8.47M	18.04K	+3.29%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.86%	523.42K	7.84M	326.35K	+165.60%
Jun 30, 2025	WOODLINE PARTNERS LP	0.77%	465.15K	6.96M	344	+0.07%
Jun 30, 2025	NORTHERN TRUST CORP	0.72%	436.95K	6.54M	57.07K	+15.02%
Jun 30, 2025	SIREN, L.L.C.	0.61%	368.6K	5.52M	0	0
Jun 30, 2025	CAPITAL WORLD INVESTORS	0.58%	350.77K	5.25M	0	0
Jun 30, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.54%	329.43K	4.93M	-59.99K	-15.41%
Jun 30, 2025	BARCLAYS PLC	0.36%	216.65K	3.24M	2.04K	+0.95%
Jun 30, 2025	CAPITOLIS LIQUID GLOBAL MARKETS LLC	0.3%	183K	2.74M	183K	+100.00%
Jun 30, 2025	ARMISTICE CAPITAL, LLC	0.28%	172K	2.57M	-28K	-14.00%
Jun 30, 2025		0.22%	135.07K	2.02M	-5.06K	-3.61%
Jun 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.21%	129.56K	1.97M	21.05K	+19.40%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.03%	114.24K	1.84M	10.55K	+10.18%
Mar 31, 2025	JANUS HENDERSON GROUP PLC	0.3%	1.04M	18.68M	-415.33K	-28.51%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.07%	248.54K	4.01M	-257.91K	-50.92%
Mar 31, 2025	CANDRIAM S.C.A.	0.07%	246.03K	3.97M	-1.56K	-0.63%
Mar 31, 2025	WOODLINE PARTNERS LP	0.13%	464.81K	7.5M	112.13K	+31.79%
Mar 31, 2025	BARCLAYS PLC	0.06%	214.61K	3.46M	91.54K	+74.38%
Mar 31, 2025	UBS GROUP AG	0.16%	552.24K	8.91M	160.05K	+40.81%
Mar 31, 2025	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.07%	257.43K	4.15M	141.96K	+122.94%
Mar 31, 2025	VR ADVISER, LLC	0.78%	2.69M	43.33M	0	0
Mar 31, 2025	BRAIDWELL LP	0.75%	2.58M	41.6M	0	0
Mar 31, 2025	NORTHERN TRUST CORP	0.11%	379.88K	6.13M	30.89K	+8.85%
Mar 31, 2025	SIREN, L.L.C.	0.11%	368.6K	5.95M	-5.4K	-1.44%
Mar 31, 2025	CITADEL ADVISORS LLC	0.04%	130.88K	2.11M	-948.42K	-87.87%
Mar 31, 2025	SOROS FUND MANAGEMENT LLC	0.04%	125K	2.02M	-125K	-50.00%
Mar 31, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.03%	108.5K	1.95M	-5.12K	-4.50%
Mar 31, 2025	HIGHVISTA STRATEGIES LLC	0.03%	95.16K	1.54M	0	0
Mar 31, 2025	POLAR CAPITAL HOLDINGS PLC	0.24%	825K	13.31M	75K	+10.00%
Mar 31, 2025	FRANKLIN RESOURCES INC	0.22%	760.63K	12.27M	-14	0.00%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.11%	382.64K	6.17M	2.99K	+0.79%
Mar 31, 2025	VICTORY CAPITAL MANAGEMENT INC	0.07%	251.85K	4.06M	-16.23K	-6.05%
Mar 31, 2025	BLACKROCK, INC.	1.03%	3.57M	57.65M	173.08K	+5.09%
Mar 31, 2025	TANG CAPITAL MANAGEMENT LLC	0.59%	2.05M	33.08M	2.05M	+100.00%
Mar 31, 2025	VANGUARD GROUP INC	0.84%	2.9M	46.76M	51.79K	+1.82%
Mar 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.79%	2.72M	43.84M	-86.34K	-3.08%
Mar 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.23%	803.2K	12.96M	-226.8K	-22.02%
Mar 31, 2025	DEEP TRACK CAPITAL, LP	0.06%	219.02K	3.53M	0	0
Mar 31, 2025	ARMISTICE CAPITAL, LLC	0.06%	200K	3.23M	0	0
Mar 31, 2025	CAPITAL INTERNATIONAL INVESTORS	0.69%	2.39M	38.6M	2.39M	+100.00%
Mar 31, 2025	BLACKSTONE INC.	0.14%	489.25K	7.89M	40.05K	+8.92%
Mar 31, 2025	AFFINITY ASSET ADVISORS, LLC	0.14%	481.68K	7.77M	-342.65K	-41.57%
Mar 31, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.13%	450K	7.26M	0	0
Mar 31, 2025	FMR LLC	2.61%	9.04M	145.84M	237.29K	+2.70%
Mar 31, 2025	MORGAN STANLEY	0.1%	335.47K	5.41M	80.21K	+31.42%
Mar 31, 2025	RTW INVESTMENTS, LP	1.05%	3.62M	58.44M	0	0
Mar 31, 2025	PERCEPTIVE ADVISORS LLC	0.67%	2.31M	37.32M	-261.45K	-10.15%
Mar 31, 2025	PARADIGM BIOCAPITAL ADVISORS LP	0.61%	2.13M	34.32M	600K	+39.29%
Mar 31, 2025	COMMODORE CAPITAL LP	0.57%	1.99M	32.08M	0	0
Mar 31, 2025	STATE STREET CORP	0.49%	1.7M	27.38M	16.18K	+0.96%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.46%	1.59M	25.71M	-10.83K	-0.68%
Mar 31, 2025	JEFFERIES FINANCIAL GROUP INC.	0.36%	1.25M	20.15M	31.9K	+2.62%
Mar 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.31%	1.07M	17.25M	-23.23K	-2.13%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.31%	1.06M	17.1M	93.43K	+9.67%
Mar 31, 2025	EMERALD ADVISERS, LLC	0.16%	547.83K	8.84M	1.04K	+0.19%
Mar 31, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.11%	389.42K	6.28M	3.04K	+0.79%
Mar 31, 2025	CAPITAL WORLD INVESTORS	0.1%	350.77K	5.66M	-27.8K	-7.34%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.06%	197.07K	3.18M	-550.48K	-73.64%
Mar 31, 2025		0.03%	120.32K	1.94M	-1.83K	-1.50%
Mar 31, 2025	STEMPOINT CAPITAL LP	0.04%	136.14K	2.2M	136.14K	+100.00%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.12%	427.08K	6.89M	419.93K	+5,879.77%

Insiders

Among the SYRE insiders holding of 6.7% of the stake in company, TURTLE CAMERON, Chief Executive Officer, holds the largest shares of 671.91K. BURROWS SCOTT L, Chief Financial Officer, is the second largest SYRE insider with ownership of 97.99K shares. ALBERS JEFFREY W., director, stands third with possession of 27.36K shares of that stake.

Insiders	Designation	Shares Held
TURTLE CAMERON	Chief Executive Officer	671.91K
BURROWS SCOTT L	Chief Financial Officer	97.99K
ALBERS JEFFREY W.	director	27.36K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Jan 02, 2026	TURTLE CAMERON	SALE	32.39	100	3.24K	671.91K
Dec 01, 2025	TURTLE CAMERON	SALE	29.83	4.01K	119.47K	686.91K
Nov 03, 2025	TURTLE CAMERON	SALE	23.66	16.85K	398.55K	701.91K
Sep 02, 2025	BURROWS SCOTT L	SALE	16.26	18.43K	299.64K	97.99K
Nov 06, 2024	ALBERS JEFFREY W.	SALE	36.76	6.7K	246.31K	27.36K
Oct 25, 2024	ALBERS JEFFREY W.	SALE	36.43	300	10.93K	34.06K
Sep 03, 2024	BURROWS SCOTT L	SALE	28.17	18.53K	522.07K	116.42K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES39.38K4

NET SHARES-39.38K4

SHARES HELD2.16M4

% NET SHARES-101.82%0%

Frequently Asked Questions