How many institutions own MDGL stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own MDGL shares is 533, representing 107.07% of the company's common stock.

Who are the major shareholders selling Madrigal Pharmaceuticals, Inc. stock?

VANGUARD FIDUCIARY TRUST CO, in the last quarter, reduced its stake in MDGL by -5.07% restricting it's holding to 121.58 thousand shares of worth nearly $65.28M. BANK OF AMERICA CORP /DE/ also lessened -29.28% of the MDGL shares from its portfolio, reducing its holding to 134.04 thousand shares of worth $71.97M. POINT72 ASSET MANAGEMENT, L.P. also shunned MDGL shares holding by -39.24% last quarter which brought its holding to 137.03 thousand shares worth $73.58M.

Investors who are buying MDGL stock?

As per its latest 13F filing, D. E. SHAW & CO., INC. increased its stake in MDGL by 38.61% in the last quarter. The institutional holder raised its holding to 107.7 thousand shares having worth more than $57.83M. ASSENAGON ASSET MANAGEMENT S.A. also added 674.74% more shares of MDGL to its portfolio, raising its holding to 124.21 thousand shares of worth $66.70M. SUSQUEHANNA INTERNATIONAL GROUP, LLP also increased its MDGL shares holding by 568.93% which brought its holding to 148.61 thousand shares worth $79.80M.

MDGL's major insiders: who are they?

The insider with the most stakes in MDGL is N/A , N/A at the company. Additionally, MDGL stock is highly held by N/A N/A and N/A N/A among others.

Did an insider recently sell MDGL stock?

Company executives, directors, and other insiders own 5.89% percent of Madrigal Pharmaceuticals, Inc.'s stock. Within the last six months, there have been 7 transaction(s) in which MDGL insiders have sold stock, totaling 3.19K shares. Insiders that have sold shares include SIBOLD WILLIAM JOHN, KELLEY SHANNON T, and SOERGEL DAVID.

Which insider recently purchased MDGL stock?

There have been 0 transaction(s) during the past 6-months in which Madrigal Pharmaceuticals, Inc. insiders have bought stock, totalling 0 shares

How much of MDGL does insiders own?

Around 664.64K Madrigal Pharmaceuticals, Inc. shares are held by insiders, which represents about 5.89% of MDGL stock.

Who is the insider with the largest stake?

MDGL N/A, N/A holds the largest portfolio of the company's shares. MDGL shares owned by N/A total nearly -.

Which institution holds the most shares in MDGL?

D. E. SHAW & CO., INC. is the largest institutional owner in MDGL which holds 107.7 thousand shares worth $57.83M or 0.37% of the total MDGL shares outstanding followed by VANGUARD FIDUCIARY TRUST CO with ownership of 121.58 thousand shares representing 0.42% of the MDGL ownership. ASSENAGON ASSET MANAGEMENT S.A. is the third largest stakeholder with 124.21 thousand shares or 0.43% of the ownership worth more than $66.70M.

Is Madrigal Pharmaceuticals, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the MDGL is concerned, it is a stock which is optionable.

Is there a short position on MDGL's shares?

Number of MDGL shares short is 1.97M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding MDGL shares are there?

As of today, 23.10M shares of MDGL are outstanding.

Is there many float in MDGL stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, MDGL has 13.72M shares in float.

MDGL short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for MDGL is 5.41.

Madrigal Pharmaceuticals (MDGL) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares8.51

Short Percent Of Float10

Shares Outstanding23.10M

Shares Float13.72M

Shares Short1.97M

Short Ratio5.41

10%

Short % of Float

8.51%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

5.89% Percentage of Shares held by All Insiders

107.07% Percentage of Shares held by All Institutions

113.77% Percentage of Float held by Institutions

533

Number of Institutions Holding Shares

Institutional Ownership

About 107.07% of MDGL shares are held by financial institutions. D. E. SHAW & CO., INC. is the top corporate investor, holding 107.7K shares valued at $57.83M. A 0.37% stake in Madrigal Pharmaceuticals, Inc. is owned by the company. VANGUARD FIDUCIARY TRUST CO owns 121.58K shares valued at $65.28M, which translates its holding of 0.42% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Jun 30, 2026	D. E. SHAW & CO., INC.	0.37%	107.7K	57.83M	30K	+38.61%
Jun 30, 2026	VANGUARD FIDUCIARY TRUST CO	0.42%	121.58K	65.28M	-6.5K	-5.07%
Jun 30, 2026	ASSENAGON ASSET MANAGEMENT S.A.	0.43%	124.21K	66.7M	108.18K	+674.74%
Jun 30, 2026	WOODLINE PARTNERS LP	0.43%	125.9K	67.6M	0	0
Jun 30, 2026	BANK OF AMERICA CORP /DE/	0.46%	134.04K	71.97M	-55.49K	-29.28%
Jun 30, 2026	POINT72 ASSET MANAGEMENT, L.P.	0.47%	137.03K	73.58M	-88.48K	-39.24%
Jun 30, 2026	MORGAN STANLEY	0.48%	139.01K	74.64M	-52.29K	-27.33%
Jun 30, 2026	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.51%	148.61K	79.8M	126.39K	+568.93%
Jun 30, 2026	ALLIANCEBERNSTEIN L.P.	0.65%	189.46K	99.18M	64.01K	+51.03%
Jun 30, 2026	INVESCO LTD.	1.03%	301.44K	161.86M	-28.08K	-8.52%
Jun 30, 2026	WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	1.11%	324.12K	174.04M	-16.4K	-4.82%
Jun 30, 2026	FMR LLC	1.22%	356.2K	191.26M	-155.53K	-30.39%
Jun 30, 2026	GEODE CAPITAL MANAGEMENT, LLC	1.29%	374.88K	201.34M	-80.99K	-17.77%
Jun 30, 2026	UBS GROUP AG	1.38%	401.71K	215.7M	283.93K	+241.07%
Jun 30, 2026	CITADEL ADVISORS LLC	1.74%	507.23K	272.36M	53.39K	+11.76%
Jun 30, 2026	STATE STREET CORP	1.81%	527.06K	283M	-82.47K	-13.53%
Jun 30, 2026		2.69%	781.73K	419.75M	-59.41K	-7.06%
Jun 30, 2026	WELLINGTON MANAGEMENT GROUP LLP	2.83%	825.71K	443.37M	130.76K	+18.81%
Jun 30, 2026	VANGUARD CAPITAL MANAGEMENT LLC	2.87%	835.67K	448.71M	8.52K	+1.03%
Jun 30, 2026	BLACKROCK, INC.	4.12%	1.2M	644.75M	-359.2K	-23.03%
Jun 30, 2026	PAULSON & CO. INC.	4.6%	1.34M	719.52M	-52.17K	-3.75%
Jun 30, 2026	CLEARBRIDGE INVESTMENTS, LLC	0.38%	109.33K	58.7M	84.88K	+347.19%
Jun 30, 2026	ERSTE ASSET MANAGEMENT GMBH	0.38%	110.21K	58.11M	-50K	-31.21%
Jun 30, 2026	CAPTION MANAGEMENT, LLC	0.4%	117.5K	63.09M	0	0
Jun 30, 2026	BANK OF NEW YORK MELLON CORP	0.44%	128.52K	69.01M	-7.39K	-5.44%
Jun 30, 2026	HOLOCENE ADVISORS, LP	0.52%	152.92K	82.11M	152.92K	+100.00%
Jun 30, 2026	HOOD RIVER CAPITAL MANAGEMENT LLC	0.58%	169.08K	90.79M	-80.43K	-32.23%
Jun 30, 2026	AVORO CAPITAL ADVISORS LLC	6.29%	1.83M	984.41M	15.15K	+0.83%
Jun 30, 2026	RTW INVESTMENTS, LP	6.84%	1.99M	1.07B	0	0
Jun 30, 2026	BAKER BROS. ADVISORS LP	7.35%	2.14M	1.15B	1.43K	+0.07%
Jun 30, 2026	JANE STREET GROUP, LLC	0.36%	104.2K	55.95M	-21.1K	-16.84%
Jun 30, 2026	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.6%	175K	93.97M	4K	+2.34%
Jun 30, 2026	TORONTO DOMINION BANK	0.62%	181.43K	97.42M	50.97K	+39.07%
Jun 30, 2026	SIXTH STREET PARTNERS MANAGEMENT COMPANY, L.P.	0.63%	184.32K	98.97M	184.32K	+100.00%
Jun 30, 2026	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.63%	184.32K	98.97M	-32.4K	-14.95%
Jun 30, 2026	PRICE T ROWE ASSOCIATES INC /MD/	0.64%	187.23K	100.53M	-140.88K	-42.94%
Jun 30, 2026	VANGUARD PORTFOLIO MANAGEMENT LLC	2.68%	781.73K	419.75M	-59.41K	-7.06%
Jun 30, 2026	JUPITER TOPCO LLC	6.64%	1.94M	1.04B	1.94M	+100.00%
Jun 30, 2026	SHIKIAR ASSET MANAGEMENT INC	0.05%	14.95K	8.03M	10.95K	+273.75%
Jun 30, 2026	VANGUARD ASSET MANAGEMENT, LTD	0.05%	15.2K	8.16M	1.11K	+7.91%
Jun 30, 2026	CITIGROUP INC	0.06%	18K	9.67M	9K	+100.00%
Jun 30, 2026	RHUMBLINE ADVISERS	0.06%	18.15K	9.75M	-3.61K	-16.59%
Jun 30, 2026	ARROWMARK COLORADO HOLDINGS LLC	0.06%	18.62K	10M	-43.82K	-70.17%
Jun 30, 2026	FIRST TRUST ADVISORS LP	0.07%	19.83K	10.65M	-2.41K	-10.83%
Jun 30, 2026	WCM INVESTMENT MANAGEMENT, LLC	0.08%	22.99K	12.12M	-575	-2.44%
Jun 30, 2026	ROCKEFELLER CAPITAL MANAGEMENT L.P.	0.1%	29.02K	15.58M	-4.83K	-14.28%
Jun 30, 2026	JPMORGAN CHASE & CO	0.1%	29.47K	16.01M	-6.84K	-18.84%
Jun 30, 2026	SWISS NATIONAL BANK	0.1%	29.94K	16.08M	720	+2.46%
Jun 30, 2026	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	0.11%	32K	17.18M	-881	-2.68%
Jun 30, 2026	UBS ASSET MANAGEMENT AMERICAS INC	0.11%	32.4K	17.4M	8.61K	+36.17%
Jun 30, 2026	SEGALL BRYANT & HAMILL, LLC	0.11%	32.44K	17.42M	574	+1.80%
Jun 30, 2026	NUVEEN, LLC	0.11%	32.63K	17.52M	-29.43K	-47.42%
Jun 30, 2026	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.12%	33.42K	17.94M	-7.51K	-18.34%
Jun 30, 2026	AFFINITY ASSET ADVISORS, LLC	0.14%	40K	21.48M	-15K	-27.27%
Jun 30, 2026	RENAISSANCE TECHNOLOGIES LLC	0.16%	45.94K	24.67M	-25.93K	-36.08%
Jun 30, 2026	RUSSELL INVESTMENTS GROUP, LTD.	0.17%	49.29K	26.47M	4.79K	+10.76%
Jun 30, 2026	SCHRODER INVESTMENT MANAGEMENT GROUP	0.18%	51.63K	27.22M	11.78K	+29.55%
Jun 30, 2026	EULAV ASSET MANAGEMENT	0.18%	52K	27.92M	3K	+6.12%
Jun 30, 2026	BNP PARIBAS ARBITRAGE, SNC	0.2%	58K	31.14M	821	+1.44%
Jun 30, 2026	VOYA INVESTMENT MANAGEMENT LLC	0.21%	61.2K	32.86M	1.23K	+2.05%
Jun 30, 2026	ALLSPRING GLOBAL INVESTMENTS HOLDINGS, LLC	0.23%	67.67K	34.81M	66.47K	+5,548.41%
Jun 30, 2026	CANDRIAM S.C.A.	0.25%	72.12K	38.69M	-12.83K	-15.10%
Jun 30, 2026	DEUTSCHE BANK AG\	0.29%	83.92K	45.06M	-14.15K	-14.43%
Jun 30, 2026	WESTFIELD CAPITAL MANAGEMENT CO LP	0.32%	93.93K	50.44M	-882	-0.93%
Jun 30, 2026	NEW YORK STATE COMMON RETIREMENT FUND	0.33%	94.74K	50.87M	19.61K	+26.11%
Jun 30, 2026	NORTHERN TRUST CORP	0.34%	98.51K	52.89M	-50.7K	-33.98%
Jun 30, 2026	PICTET ASSET MANAGEMENT HOLDING SA	0.66%	192.9K	103.49M	5.66K	+3.02%
Jun 30, 2026	ARTISAN PARTNERS LIMITED PARTNERSHIP	0.72%	210.21K	112.87M	26.67K	+14.53%
Jun 30, 2026	NORGES BANK	0.73%	213.89K	114.85M	213.89K	+100.00%
Jun 30, 2026	AMERIPRISE FINANCIAL INC	0.79%	231.21K	124.15M	133.02K	+135.49%
Jun 30, 2026	POLAR CAPITAL HOLDINGS PLC	0.84%	244.27K	131.16M	-45.04K	-15.57%
Jun 30, 2026	GOLDMAN SACHS GROUP INC	0.85%	246.28K	132.24M	-31.09K	-11.21%
Jun 30, 2026	LORD, ABBETT & CO. LLC	0.97%	281.5K	151.15M	38.77K	+15.97%
Jun 30, 2026	ARMISTICE CAPITAL, LLC	0.99%	288K	154.64M	23.42K	+8.85%
Jun 30, 2026	AMERICAN CENTURY COMPANIES INC	0.34%	99.4K	53.37M	-64.54K	-39.37%
Jun 30, 2026	FIERA CAPITAL CORP	0.34%	99.86K	53.62M	-74.15K	-42.61%
Jun 30, 2026	MARSHALL WACE, LLP	0.35%	101.86K	54.69M	79.96K	+365.07%
Mar 31, 2026	RAYMOND JAMES FINANCIAL INC	0.3%	66.53K	34.13M	-195	-0.29%
Mar 31, 2026	POINT72 ASSET MANAGEMENT, L.P.	0.78%	225.51K	118.05M	99.08K	+78.36%
Mar 31, 2026	LORD, ABBETT & CO. LLC	0.84%	242.73K	127.06M	-2.07K	-0.85%
Mar 31, 2026	HOOD RIVER CAPITAL MANAGEMENT LLC	0.86%	249.51K	130.61M	1.95K	+0.79%
Mar 31, 2026	GOLDMAN SACHS GROUP INC	0.96%	277.37K	145.2M	-28.48K	-9.31%
Mar 31, 2026	POLAR CAPITAL HOLDINGS PLC	1%	289.31K	151.45M	19.16K	+7.09%
Mar 31, 2026	PRICE T ROWE ASSOCIATES INC /MD/	1.13%	328.11K	171.76M	14.45K	+4.61%
Mar 31, 2026	FMR LLC	1.76%	511.73K	267.87M	72.33K	+16.46%
Mar 31, 2026	JANUS HENDERSON GROUP PLC	6.95%	2.02M	1.05B	433.8K	+27.37%
Mar 31, 2026	FIERA CAPITAL CORP	0.6%	174.01K	91.09M	4.56K	+2.69%
Mar 31, 2026	DEUTSCHE BANK AG\	0.34%	98.07K	51.34M	-94.04K	-48.95%
Mar 31, 2026	ARTISAN PARTNERS LIMITED PARTNERSHIP	0.63%	183.54K	96.08M	-15.15K	-7.63%
Mar 31, 2026	WESTFIELD CAPITAL MANAGEMENT CO LP	0.33%	94.81K	49.63M	94.81K	+100.00%
Mar 31, 2026	AMERIPRISE FINANCIAL INC	0.44%	98.18K	51.4M	68.89K	+235.24%
Mar 31, 2026	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.56%	163.3K	85.48M	41.5K	+34.07%
Mar 31, 2026	AMERICAN CENTURY COMPANIES INC	0.56%	163.93K	85.81M	-21.18K	-11.44%
Mar 31, 2026	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.59%	171K	89.51M	31.38K	+22.48%
Mar 31, 2026	TRI LOCUM PARTNERS LP	0.36%	103.29K	54.07M	17.27K	+20.07%
Mar 31, 2026	DRIEHAUS CAPITAL MANAGEMENT LLC	0.38%	110.96K	58.08M	-706	-0.63%
Mar 31, 2026	CITADEL ADVISORS LLC	0.39%	112.4K	58.84M	7.5K	+7.15%
Mar 31, 2026	CAPTION MANAGEMENT, LLC	0.4%	117.5K	61.51M	117.5K	+100.00%
Mar 31, 2026	UBS GROUP AG	0.41%	117.78K	61.65M	15.14K	+14.75%
Mar 31, 2026	ALLIANCEBERNSTEIN L.P.	0.43%	125.45K	73.05M	103.54K	+472.50%
Mar 31, 2026	WOODLINE PARTNERS LP	0.43%	125.9K	65.9M	240	+0.19%
Mar 31, 2026	VANGUARD FIDUCIARY TRUST CO	0.44%	128.08K	67.05M	128.08K	+100.00%
Mar 31, 2026	TORONTO DOMINION BANK	0.45%	130.46K	68.29M	130.46K	+100.00%
Mar 31, 2026	BANK OF NEW YORK MELLON CORP	0.47%	135.91K	71.14M	-961	-0.70%
Mar 31, 2026	NORTHERN TRUST CORP	0.51%	149.21K	78.11M	-2.59K	-1.70%
Mar 31, 2026	ERSTE ASSET MANAGEMENT GMBH	0.55%	160.21K	80.96M	19.11K	+13.54%
Mar 31, 2026	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.64%	185.33K	97.02M	162.11K	+697.95%
Mar 31, 2026	PICTET ASSET MANAGEMENT HOLDING SA	0.64%	187.24K	97.91M	5.29K	+2.91%
Mar 31, 2026	BANK OF AMERICA CORP /DE/	0.65%	189.53K	99.21M	-226.5K	-54.44%
Mar 31, 2026	MORGAN STANLEY	0.66%	191.29K	100.14M	40.83K	+27.14%
Mar 31, 2026	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.75%	216.72K	113.45M	-2.38K	-1.09%
Mar 31, 2026	ARMISTICE CAPITAL, LLC	0.91%	264.58K	138.5M	-1.12K	-0.42%
Mar 31, 2026	WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	1.17%	340.52K	178.25M	-13.7K	-3.87%
Mar 31, 2026	GEODE CAPITAL MANAGEMENT, LLC	1.57%	455.87K	238.68M	4.13K	+0.91%
Mar 31, 2026	STATE STREET CORP	2.1%	609.53K	319.07M	26.52K	+4.55%
Mar 31, 2026	WELLINGTON MANAGEMENT GROUP LLP	2.39%	694.96K	363.79M	233.56K	+50.62%
Mar 31, 2026	PAULSON & CO. INC.	4.8%	1.39M	728.77M	-315.33K	-18.47%
Mar 31, 2026	INVESCO LTD.	1.14%	329.52K	172.49M	-35.8K	-9.80%
Mar 31, 2026	AVORO CAPITAL ADVISORS LLC	6.26%	1.82M	951.76M	10.68K	+0.59%
Mar 31, 2026	RTW INVESTMENTS, LP	6.87%	1.99M	1.04B	0	0
Mar 31, 2026	TAO CAPITAL MANAGEMENT LP	0.09%	21K	10.99M	0	0
Mar 31, 2026	RHUMBLINE ADVISERS	0.1%	21.76K	11.39M	-1.93K	-8.13%
Mar 31, 2026	FIRST TRUST ADVISORS LP	0.1%	22.23K	11.64M	-2.59K	-10.42%
Mar 31, 2026	CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM	0.1%	23.2K	12.14M	-8.09K	-25.85%
Mar 31, 2026	WCM INVESTMENT MANAGEMENT, LLC	0.11%	23.56K	11.91M	6.31K	+36.55%
Mar 31, 2026	UBS ASSET MANAGEMENT AMERICAS INC	0.11%	23.8K	12.46M	-50	-0.21%
Mar 31, 2026	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.11%	24.05K	12.59M	4.5K	+23.02%
Mar 31, 2026	SEI INVESTMENTS CO	0.11%	24.2K	12.67M	1.12K	+4.86%
Mar 31, 2026	CLEARBRIDGE INVESTMENTS, LLC	0.11%	24.45K	12.8M	24.45K	+100.00%
Mar 31, 2026	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.12%	27.94K	14.62M	-30.36K	-52.08%
Mar 31, 2026	SWISS NATIONAL BANK	0.13%	29.22K	15.3M	640	+2.24%
Mar 31, 2026	CITIGROUP INC	0.11%	25.59K	13.4M	2.26K	+9.70%
Mar 31, 2026	ALKEON CAPITAL MANAGEMENT LLC	0.36%	80K	41.88M	-160K	-66.67%
Mar 31, 2026	WELLS FARGO & COMPANY/MN	0.14%	32.21K	16.86M	-11.25K	-25.88%
Mar 31, 2026	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	0.15%	32.88K	17.21M	17.53K	+114.24%
Mar 31, 2026	ROCKEFELLER CAPITAL MANAGEMENT L.P.	0.15%	33.85K	17.72M	14.19K	+72.16%
Mar 31, 2026	JANE STREET GROUP, LLC	0.43%	125.3K	65.59M	-3.1K	-2.41%
Mar 31, 2026	JPMORGAN CHASE & CO	0.16%	36.32K	18.35M	-3.76K	-9.39%
Mar 31, 2026	EMERALD ADVISERS, LLC	0.17%	37.65K	19.71M	-1.26K	-3.24%
Mar 31, 2026	SCHRODER INVESTMENT MANAGEMENT GROUP	0.18%	39.85K	20.14M	10.8K	+37.18%
Mar 31, 2026	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.18%	40.93K	21.42M	-9.71K	-19.17%
Mar 31, 2026	RUSSELL INVESTMENTS GROUP, LTD.	0.2%	44.5K	23.3M	-3.66K	-7.59%
Mar 31, 2026	EULAV ASSET MANAGEMENT	0.22%	49K	25.65M	0	0
Mar 31, 2026	AFFINITY ASSET ADVISORS, LLC	0.25%	55K	28.79M	23.87K	+76.67%
Mar 31, 2026	BNP PARIBAS ARBITRAGE, SNC	0.25%	57.18K	29.93M	-16.53K	-22.43%
Mar 31, 2026	VOYA INVESTMENT MANAGEMENT LLC	0.27%	59.97K	31.39M	-4.28K	-6.67%
Mar 31, 2026	NUVEEN, LLC	0.28%	62.06K	32.49M	-56.3K	-47.57%
Mar 31, 2026	RENAISSANCE TECHNOLOGIES LLC	0.32%	71.87K	37.62M	-11.99K	-14.30%
Mar 31, 2026	FRANKLIN RESOURCES INC	0.33%	74.04K	38.76M	-12.04K	-13.98%
Mar 31, 2026	NEW YORK STATE COMMON RETIREMENT FUND	0.33%	75.13K	39.33M	-804	-1.06%
Mar 31, 2026	CANDRIAM S.C.A.	0.38%	84.95K	44.47M	21.04K	+32.93%
Mar 31, 2026		2.9%	841.15K	440.31M	841.15K	+100.00%
Mar 31, 2026	BLACKROCK, INC.	5.37%	1.56M	816.59M	-84.79K	-5.15%
Mar 31, 2026	BAKER BROS. ADVISORS LP	7.38%	2.14M	1.12B	0	0
Mar 31, 2026	LOGOS GLOBAL MANAGEMENT LP	0.29%	85K	44.49M	85K	+100.00%
Mar 31, 2026	683 CAPITAL MANAGEMENT, LLC	0.31%	90K	47.11M	-9K	-9.09%
Mar 31, 2026	VANGUARD CAPITAL MANAGEMENT LLC	2.85%	827.14K	432.99M	827.14K	+100.00%
Dec 31, 2025	JANE STREET GROUP, LLC	0.41%	93.11K	54.22M	-2.62K	-2.74%
Dec 31, 2025	UBS GROUP AG	0.46%	102.64K	59.77M	-114.7K	-52.77%
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.5%	113.4K	66.04M	-6.4K	-5.34%
Dec 31, 2025	SEI INVESTMENTS CO	0.1%	23.08K	13.44M	3.96K	+20.72%
Dec 31, 2025	CITIGROUP INC	0.1%	22.5K	13.1M	-4.5K	-16.67%
Dec 31, 2025	RHUMBLINE ADVISERS	0.11%	23.69K	13.8M	-3.57K	-13.10%
Dec 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.11%	23.85K	13.89M	370	+1.58%
Dec 31, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.11%	25K	14.56M	-10.1K	-28.77%
Dec 31, 2025	BARCLAYS PLC	0.17%	38.72K	22.55M	-11.19K	-22.42%
Dec 31, 2025	EMERALD ADVISERS, LLC	0.17%	38.91K	22.66M	-11.82K	-23.30%
Dec 31, 2025	MARSHALL WACE, LLP	0.18%	39.58K	23.05M	38.88K	+5,554.00%
Dec 31, 2025	JPMORGAN CHASE & CO	0.18%	40.08K	23.34M	-7.75K	-16.19%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.19%	43.46K	25.31M	5.64K	+14.91%
Dec 31, 2025	EULAV ASSET MANAGEMENT	0.22%	49K	28.53M	-2K	-3.92%
Dec 31, 2025	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.23%	50.63K	29.48M	53	+0.10%
Dec 31, 2025	ENSIGN PEAK ADVISORS, INC	0.23%	51.01K	29.71M	-2.26K	-4.24%
Dec 31, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.26%	58.3K	33.95M	-27.48K	-32.04%
Dec 31, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.29%	64.25K	37.42M	4.82K	+8.10%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.33%	73.71K	42.92M	2.95K	+4.17%
Dec 31, 2025	SQUAREPOINT OPS LLC	0.33%	74.93K	43.64M	45K	+150.31%
Dec 31, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.34%	75.93K	44.22M	6.66K	+9.61%
Dec 31, 2025	ARMISTICE CAPITAL, LLC	1.18%	265.71K	154.73M	145.72K	+121.45%
Dec 31, 2025	ARROWMARK COLORADO HOLDINGS LLC	0.37%	82.62K	48.12M	-40.64K	-32.97%
Dec 31, 2025	D. E. SHAW & CO., INC.	0.39%	88.55K	51.57M	-7.63K	-7.93%
Dec 31, 2025	683 CAPITAL MANAGEMENT, LLC	0.44%	99K	57.65M	-53K	-34.87%
Dec 31, 2025	CITADEL ADVISORS LLC	0.47%	104.9K	61.09M	41.1K	+64.42%
Dec 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.5%	111.67K	65.03M	-4.31K	-3.71%
Dec 31, 2025	HOOD RIVER CAPITAL MANAGEMENT LLC	1.1%	247.56K	144.16M	4.75K	+1.96%
Dec 31, 2025	POLAR CAPITAL HOLDINGS PLC	1.2%	270.15K	157.32M	5K	+1.88%
Dec 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	1.4%	313.66K	182.66M	-38.86K	-11.02%
Dec 31, 2025	INVESCO LTD.	1.62%	365.31K	212.74M	65.75K	+21.95%
Dec 31, 2025	FMR LLC	1.95%	439.4K	255.88M	38.26K	+9.54%
Dec 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	2.05%	461.4K	268.69M	56.95K	+14.08%
Dec 31, 2025	JANUS HENDERSON GROUP PLC	7.05%	1.58M	918.2M	-257.85K	-13.99%
Dec 31, 2025	PAULSON & CO. INC.	7.59%	1.71M	994.36M	-200K	-10.48%
Dec 31, 2025	AVORO CAPITAL ADVISORS LLC	8.04%	1.81M	1.05B	-25.5K	-1.39%
Dec 31, 2025	RTW INVESTMENTS, LP	8.87%	1.99M	1.16B	0	0
Dec 31, 2025	BAKER BROS. ADVISORS LP	9.53%	2.14M	1.25B	0	0
Dec 31, 2025	WCM INVESTMENT MANAGEMENT, LLC	0.08%	17.25K	10.07M	-1.04K	-5.67%
Dec 31, 2025	NEUBERGER BERMAN GROUP LLC	0.08%	18.66K	10.87M	129	+0.70%
Dec 31, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.08%	19.08K	11.11M	3.79K	+24.78%
Dec 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.09%	19.32K	11.25M	13.52K	+233.18%
Dec 31, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.09%	19.55K	11.38M	1.3K	+7.12%
Dec 31, 2025	NUVEEN, LLC	0.53%	118.36K	68.93M	44.65K	+60.57%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.61%	136.87K	79.7M	39.09K	+39.98%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	1.36%	305.85K	178.11M	-80.25K	-20.79%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.01%	451.74K	263.11M	5.51K	+1.23%
Dec 31, 2025	STATE STREET CORP	2.59%	583K	339.51M	-75.09K	-11.41%
Dec 31, 2025	BLACKROCK, INC.	7.32%	1.64M	957.8M	85.04K	+5.45%
Dec 31, 2025	VANGUARD GROUP INC	8.05%	1.81M	1.05B	-3.16K	-0.17%
Dec 31, 2025	MORGAN STANLEY	0.67%	150.46K	87.62M	-99.19K	-39.73%
Dec 31, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.62%	139.62K	81.31M	1.87K	+1.36%
Dec 31, 2025	ERSTE ASSET MANAGEMENT GMBH	0.63%	141.1K	82.32M	-60K	-29.84%
Dec 31, 2025	WOODLINE PARTNERS LP	0.56%	125.66K	73.18M	21.81K	+21.00%
Dec 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.56%	126.44K	73.63M	85.2K	+206.64%
Dec 31, 2025	NORTHERN TRUST CORP	0.68%	151.8K	88.4M	-8.19K	-5.12%
Dec 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.81%	181.95K	106.02M	-9.85K	-5.13%
Dec 31, 2025	AMERICAN CENTURY COMPANIES INC	0.82%	185.12K	107.8M	19.5K	+11.77%
Dec 31, 2025	DEUTSCHE BANK AG\	0.85%	192.11K	111.87M	154.77K	+414.46%
Dec 31, 2025	ARTISAN PARTNERS LIMITED PARTNERSHIP	0.88%	198.69K	115.71M	-7.56K	-3.67%
Dec 31, 2025	ALKEON CAPITAL MANAGEMENT LLC	1.07%	240K	139.76M	120K	+100.00%
Dec 31, 2025	LORD, ABBETT & CO. LLC	1.09%	244.8K	142.56M	142.65K	+139.66%
Dec 31, 2025	WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	1.58%	354.22K	206.28M	-57.58K	-13.98%
Dec 31, 2025	FIERA CAPITAL CORP	0.75%	169.46K	98.68M	41.66K	+32.59%
Dec 31, 2025	NORGES BANK	0.87%	196.39K	114.37M	196.39K	+100.00%
Dec 31, 2025	RHEOS CAPITAL WORKS INC.	0.12%	26.22K	15.27M	-17K	-39.34%
Dec 31, 2025	SWISS NATIONAL BANK	0.13%	28.58K	16.64M	680	+2.44%
Dec 31, 2025	AFFINITY ASSET ADVISORS, LLC	0.14%	31.13K	18.13M	-83.87K	-72.93%
Dec 31, 2025	CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM	0.14%	31.29K	18.22M	7.19K	+29.83%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	1.85%	416.03K	242.27M	171.73K	+70.30%
Dec 31, 2025	RAYMOND JAMES FINANCIAL INC	0.3%	66.72K	38.91M	-3.86K	-5.47%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.97%	219.1K	127.59M	5.45K	+2.55%
Dec 31, 2025	CANDRIAM S.C.A.	0.28%	63.91K	37.22M	13.94K	+27.90%
Dec 31, 2025	ATIKA CAPITAL MANAGEMENT LLC	0.15%	34K	19.8M	34K	+100.00%
Dec 31, 2025	SEGALL BRYANT & HAMILL, LLC	0.15%	33.52K	19.52M	11.03K	+49.04%
Dec 31, 2025	BIOIMPACT CAPITAL LLC	0.43%	96.78K	56.36M	-3.64K	-3.62%
Dec 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.37%	83.86K	48.84M	-36.82K	-30.51%
Dec 31, 2025	TRI LOCUM PARTNERS LP	0.38%	86.02K	50.09M	18.32K	+27.05%
Dec 31, 2025	FRANKLIN RESOURCES INC	0.38%	86.08K	50.13M	10.51K	+13.90%
Sep 30, 2025	FRANKLIN RESOURCES INC	0.34%	75.57K	34.66M	14.86K	+24.47%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.74%	386.1K	177.09M	196.26K	+103.38%
Sep 30, 2025	WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	1.85%	411.8K	188.88M	61.51K	+17.56%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	1.82%	404.46K	185.51M	397.08K	+5,381.16%
Sep 30, 2025	LORD, ABBETT & CO. LLC	0.46%	102.14K	46.85M	17.93K	+21.29%
Sep 30, 2025	BIOIMPACT CAPITAL LLC	0.45%	100.42K	46.06M	0	0
Sep 30, 2025	VANGUARD GROUP INC	8.16%	1.81M	831.12M	-65.23K	-3.47%
Sep 30, 2025	BLACKROCK, INC.	7.02%	1.56M	715.38M	120.99K	+8.41%
Sep 30, 2025	FMR LLC	1.81%	401.14K	183.99M	-44.2K	-9.93%
Sep 30, 2025	EULAV ASSET MANAGEMENT	0.23%	51K	23.39M	20K	+64.52%
Sep 30, 2025	EMERALD ADVISERS, LLC	0.23%	50.74K	23.27M	-2.37K	-4.46%
Sep 30, 2025	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.23%	50.58K	23.2M	-19.98K	-28.32%
Sep 30, 2025	CANDRIAM S.C.A.	0.23%	49.97K	22.92M	0	0
Sep 30, 2025	BARCLAYS PLC	0.22%	49.91K	22.89M	-12.76K	-20.36%
Sep 30, 2025	JPMORGAN CHASE & CO	0.22%	47.82K	21.93M	-8.03K	-14.38%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.2%	44.89K	20.59M	10.87K	+31.96%
Sep 30, 2025	RHEOS CAPITAL WORKS INC.	0.19%	43.22K	19.82M	0	0
Sep 30, 2025	TAO CAPITAL MANAGEMENT LP	0.18%	41K	18.81M	-71.79K	-63.65%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.17%	37.82K	17.35M	1.15K	+3.13%
Sep 30, 2025	DEUTSCHE BANK AG\	0.17%	37.34K	17.13M	13.23K	+54.85%
Sep 30, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.16%	35.09K	16.09M	-1.83K	-4.95%
Sep 30, 2025		0.14%	30.37K	13.93M	30.37K	+100.00%
Sep 30, 2025	SWISS NATIONAL BANK	0.13%	27.9K	12.8M	500	+1.82%
Sep 30, 2025	BRIDGEWATER ASSOCIATES, LP	0.13%	27.79K	12.74M	27.79K	+100.00%
Sep 30, 2025	RHUMBLINE ADVISERS	0.12%	27.26K	12.5M	900	+3.41%
Sep 30, 2025	CITIGROUP INC	0.12%	27K	12.38M	500	+1.89%
Sep 30, 2025	LPL FINANCIAL LLC	0.1%	22.54K	10.34M	8.42K	+59.61%
Sep 30, 2025	SEGALL BRYANT & HAMILL, LLC	0.1%	22.49K	10.32M	22.49K	+100.00%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.1%	21.67K	9.94M	-1.44K	-6.22%
Sep 30, 2025	JUMP FINANCIAL, LLC	0.09%	20.96K	9.61M	20.96K	+100.00%
Sep 30, 2025	SEI INVESTMENTS CO	0.09%	19.12K	8.77M	1.57K	+8.97%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.08%	18.72K	8.58M	-5.82K	-23.72%
Sep 30, 2025	NEUBERGER BERMAN GROUP LLC	0.08%	18.53K	8.5M	18.53K	+100.00%
Sep 30, 2025	SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)	0.08%	18.36K	8.44M	14.39K	+361.61%
Sep 30, 2025	WCM INVESTMENT MANAGEMENT, LLC	0.08%	18.29K	8.1M	18.29K	+100.00%
Sep 30, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.08%	18.25K	8.37M	18.25K	+100.00%
Sep 30, 2025	JANUS HENDERSON GROUP PLC	8.3%	1.84M	845.28M	-349.06K	-15.93%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.01%	446.23K	204.7M	31.84K	+7.68%
Sep 30, 2025	ECOR1 CAPITAL, LLC	0.34%	75K	34.4M	0	0
Sep 30, 2025	NUVEEN, LLC	0.33%	73.72K	33.81M	32.18K	+77.49%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.32%	70.76K	32.45M	1.72K	+2.49%
Sep 30, 2025	RAYMOND JAMES FINANCIAL INC	0.32%	70.58K	32.37M	15.65K	+28.49%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.31%	69.27K	31.77M	8.21K	+13.45%
Sep 30, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.31%	68.34K	31.34M	60.34K	+754.20%
Sep 30, 2025	TRI LOCUM PARTNERS LP	0.3%	67.71K	31.05M	-30.06K	-30.75%
Sep 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.27%	59.44K	27.26M	8.35K	+16.34%
Sep 30, 2025	IRON TRIANGLE PARTNERS LP	0.26%	58.38K	26.78M	58.38K	+100.00%
Sep 30, 2025	ENSIGN PEAK ADVISORS, INC	0.24%	53.27K	24.43M	4.87K	+10.06%
Sep 30, 2025	BAKER BROS. ADVISORS LP	9.64%	2.14M	982.31M	165.68K	+8.38%
Sep 30, 2025	RTW INVESTMENTS, LP	8.98%	1.99M	914.42M	0	0
Sep 30, 2025	PAULSON & CO. INC.	8.59%	1.91M	874.9M	-182K	-8.71%
Sep 30, 2025	AVORO CAPITAL ADVISORS LLC	8.25%	1.83M	840.72M	-42K	-2.24%
Sep 30, 2025	STATE STREET CORP	2.96%	658.1K	301.84M	-32.62K	-4.72%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	1.59%	352.52K	161.69M	-155.94K	-30.67%
Sep 30, 2025	INVESCO LTD.	1.35%	299.57K	137.4M	99.21K	+49.52%
Sep 30, 2025	POLAR CAPITAL HOLDINGS PLC	1.19%	265.15K	121.62M	39.74K	+17.63%
Sep 30, 2025	MORGAN STANLEY	1.12%	249.65K	114.5M	1.69K	+0.68%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	1.1%	244.29K	112.05M	-32.93K	-11.88%
Sep 30, 2025	HOOD RIVER CAPITAL MANAGEMENT LLC	1.09%	242.81K	111.37M	-1.93K	-0.79%
Sep 30, 2025	UBS GROUP AG	0.98%	217.34K	99.69M	-288.37K	-57.02%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.96%	213.65K	97.99M	60.57K	+39.56%
Sep 30, 2025	ARTISAN PARTNERS LIMITED PARTNERSHIP	0.93%	206.25K	94.6M	4.68K	+2.32%
Sep 30, 2025	ERSTE ASSET MANAGEMENT GMBH	0.91%	201.1K	89.11M	0	0
Sep 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.86%	191.8K	87.71M	-16.47K	-7.91%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.75%	165.62K	75.96M	-2.17K	-1.29%
Sep 30, 2025	NORTHERN TRUST CORP	0.72%	159.99K	73.38M	17.12K	+11.98%
Sep 30, 2025	683 CAPITAL MANAGEMENT, LLC	0.68%	152K	69.72M	0	0
Sep 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.62%	137.75K	63.18M	-2.55K	-1.82%
Sep 30, 2025	FIERA CAPITAL CORP	0.58%	127.8K	58.62M	-2.82K	-2.16%
Sep 30, 2025	ARROWMARK COLORADO HOLDINGS LLC	0.56%	123.26K	56.53M	-21.55K	-14.88%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.54%	120.68K	55.35M	109.85K	+1,013.71%
Sep 30, 2025	ALKEON CAPITAL MANAGEMENT LLC	0.54%	120K	55.04M	120K	+100.00%
Sep 30, 2025	ARMISTICE CAPITAL, LLC	0.54%	119.98K	55.03M	-4.02K	-3.24%
Sep 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.52%	115.97K	53.19M	115.97K	+100.00%
Sep 30, 2025	AFFINITY ASSET ADVISORS, LLC	0.52%	115K	52.75M	35K	+43.75%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.47%	104.82K	48.08M	4.5K	+4.48%
Sep 30, 2025	WOODLINE PARTNERS LP	0.47%	103.85K	47.63M	-55.78K	-34.94%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.44%	97.78K	44.85M	8.84K	+9.93%
Sep 30, 2025	D. E. SHAW & CO., INC.	0.43%	96.18K	44.11M	-15.8K	-14.11%
Sep 30, 2025	JANE STREET GROUP, LLC	0.43%	95.73K	43.91M	95.73K	+100.00%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.4%	88.5K	40.59M	-287.66K	-76.47%
Sep 30, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.39%	85.77K	39.34M	-14.32K	-14.31%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.37%	82.4K	37.79M	47.9K	+138.84%
Jun 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.94%	208.27K	62.99M	1.22K	+0.59%
Jun 30, 2025	NORGES BANK	0.79%	176.47K	53.41M	176.47K	+100.00%
Jun 30, 2025	FMR LLC	2.01%	445.34K	134.78M	-206.76K	-31.71%
Jun 30, 2025	RAYMOND JAMES FINANCIAL INC	0.25%	54.93K	16.62M	1.02K	+1.89%
Jun 30, 2025	GROUPAMA ASSET MANAGMENT	0.18%	40.89K	12.3M	7.44K	+22.24%
Jun 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.15%	33.21K	10.05M	2.8K	+9.21%
Jun 30, 2025	GILDER GAGNON HOWE & CO LLC	0.14%	31.55K	9.55M	-103	-0.33%
Jun 30, 2025	LOGOS GLOBAL MANAGEMENT LP	0.23%	50K	15.13M	50K	+100.00%
Jun 30, 2025	PITCAIRN CO	0.13%	29.78K	2.1M	28.8K	+2,942.19%
Jun 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.11%	24.53K	7.42M	-5.37K	-17.96%
Jun 30, 2025	TD ASSET MANAGEMENT INC	0.1%	23.24K	7.03M	1K	+4.50%
Jun 30, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.45%	100.1K	30.29M	-2.27K	-2.21%
Jun 30, 2025	BIOIMPACT CAPITAL LLC	0.45%	100.42K	30.39M	0	0
Jun 30, 2025	D. E. SHAW & CO., INC.	0.5%	111.98K	33.89B	12.98K	+13.11%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.87%	414.39K	125.43M	-6.48K	-1.54%
Jun 30, 2025	HOOD RIVER CAPITAL MANAGEMENT LLC	1.1%	244.74K	74.07M	744	+0.30%
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.33%	73.4K	22.21M	-109.6K	-59.89%
Jun 30, 2025	ERSTE ASSET MANAGEMENT GMBH	0.91%	201.1K	60.82M	36.7K	+22.32%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.85%	189.84K	57.45B	201	+0.11%
Jun 30, 2025	CITADEL ADVISORS LLC	0.93%	207.34K	62.75B	206.54K	+25,785.02%
Jun 30, 2025	MORGAN STANLEY	1.12%	247.96K	75.04B	-136.87K	-35.57%
Jun 30, 2025	BLACKROCK, INC.	6.48%	1.44M	435.42M	-47.74K	-3.21%
Jun 30, 2025	VANGUARD GROUP INC	8.45%	1.88M	568.14M	187.17K	+11.07%
Jun 30, 2025	JANUS HENDERSON GROUP PLC	9.87%	2.19M	663.28M	-14.1K	-0.64%
Jun 30, 2025	BARCLAYS PLC	0.28%	62.67K	18.97M	15.8K	+33.72%
Jun 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.31%	69.04K	20.89M	65.56K	+1,886.10%
Jun 30, 2025	ECOR1 CAPITAL, LLC	0.34%	75K	22.7M	0	0
Jun 30, 2025	AFFINITY ASSET ADVISORS, LLC	0.36%	80K	24.21M	0	0
Jun 30, 2025	RTW INVESTMENTS, LP	8.98%	1.99M	603.37M	0	0
Jun 30, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.17%	36.92K	11.17M	1.68K	+4.77%
Jun 30, 2025		0.91%	201.1K	60.82M	36.7K	+22.32%
Jun 30, 2025	RHEOS CAPITAL WORKS INC.	0.19%	43.22K	13.08M	0	0
Jun 30, 2025	EMERALD ADVISERS, LLC	0.24%	53.11K	16.07M	5.2K	+10.85%
Jun 30, 2025	MARSHALL WACE, LLP	0.25%	55.12K	16.68M	52.32K	+1,868.54%
Jun 30, 2025	BRAIDWELL LP	0.27%	60.78K	18.39M	12.09K	+24.83%
Jun 30, 2025	FIERA CAPITAL CORP	0.59%	130.62K	39.53M	-1.56K	-1.18%
Jun 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.63%	140.3K	42.46M	-26.4K	-15.84%
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	0.76%	167.78K	50.78M	9.48K	+5.99%
Jun 30, 2025	ARTISAN PARTNERS LIMITED PARTNERSHIP	0.91%	201.57K	61M	63.83K	+46.34%
Jun 30, 2025	PAULSON & CO. INC.	9.41%	2.09M	632.37M	-10K	-0.48%
Jun 30, 2025	NORTHERN TRUST CORP	0.64%	142.87K	43.24M	-8.02K	-5.31%
Jun 30, 2025	683 CAPITAL MANAGEMENT, LLC	0.68%	152K	46M	0	0
Jun 30, 2025	INVESCO LTD.	0.9%	200.36K	60.64M	67.42K	+50.72%
Jun 30, 2025	TAO CAPITAL MANAGEMENT LP	0.51%	112.79K	34.13M	0	0
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.69%	153.09K	46.33M	1.83K	+1.21%
Jun 30, 2025	POLAR CAPITAL HOLDINGS PLC	1.02%	225.41K	68.22M	75.19K	+50.05%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	1.25%	277.22K	83.9M	31.26K	+12.71%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.69%	376.16K	113.84M	184.55K	+96.32%
Jun 30, 2025	TRI LOCUM PARTNERS LP	0.44%	97.77K	29.59M	59.9K	+158.17%
Jun 30, 2025	BAKER BROS. ADVISORS LP	8.9%	1.98M	598.02M	1.43K	+0.07%
Jun 30, 2025	AVORO CAPITAL ADVISORS LLC	8.44%	1.88M	567.45M	-147.22K	-7.28%
Jun 30, 2025	STATE STREET CORP	3.11%	690.72K	209.04M	-67.8K	-8.94%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.29%	508.46K	153.88M	-34.17K	-6.30%
Jun 30, 2025	WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	1.58%	350.29K	106.01M	-2.87K	-0.81%
Jun 30, 2025	JANE STREET GROUP, LLC	1.4%	310.1K	93.85M	36.9K	+13.51%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.4%	88.94K	26.92M	28.15K	+46.31%
Jun 30, 2025	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.32%	70.56K	21.35M	218	+0.31%
Jun 30, 2025	UBS GROUP AG	2.28%	505.71K	153.05M	184.21K	+57.29%
Jun 30, 2025	ARMISTICE CAPITAL, LLC	0.56%	124K	37.53M	-11.88K	-8.74%
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.5%	110.88K	33.56M	45.02K	+68.35%
Jun 30, 2025	LORD, ABBETT & CO. LLC	0.38%	84.22K	25.49M	-33.81K	-28.64%
Jun 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.28%	61.06K	18.48M	16.29K	+36.39%
Jun 30, 2025	ARROWMARK COLORADO HOLDINGS LLC	0.65%	144.81K	43.82M	-35.3K	-19.60%
Jun 30, 2025	WOODLINE PARTNERS LP	0.72%	159.62K	48.31M	-157.81K	-49.71%
Jun 30, 2025	EULAV ASSET MANAGEMENT	0.14%	31K	9.38M	21K	+210.00%
Jun 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.16%	34.5K	10.44M	7.29K	+26.77%
Jun 30, 2025	UNIVERSITY OF WISCONSIN FOUNDATION	0.22%	48.38K	14.64M	0	0
Jun 30, 2025	ENSIGN PEAK ADVISORS, INC	0.22%	48.4K	14.65M	0	0
Jun 30, 2025	CANDRIAM S.C.A.	0.23%	49.97K	15.12M	28.59K	+133.79%
Jun 30, 2025	STEMPOINT CAPITAL LP	0.24%	52.69K	15.95M	11.76K	+28.72%
Mar 31, 2025	FMR LLC	2.95%	652.1K	215.99M	-215.75K	-24.86%
Mar 31, 2025	CITADEL ADVISORS LLC	0.31%	68.5K	22.69M	-16.9K	-19.79%
Mar 31, 2025	WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	1.6%	353.16K	116.98M	-18.62K	-5.01%
Mar 31, 2025	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.32%	70.34K	23.29M	162	+0.23%
Mar 31, 2025	LORD, ABBETT & CO. LLC	0.53%	118.02K	39.09M	69.11K	+141.27%
Mar 31, 2025	ARMISTICE CAPITAL, LLC	0.62%	135.88K	45.01M	35.88K	+35.88%
Mar 31, 2025	MORGAN STANLEY	1.74%	384.83K	127.47M	166.35K	+76.14%
Mar 31, 2025	HOLOCENE ADVISORS, LP	1.77%	390.55K	129.36M	390.55K	+100.00%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.91%	420.88K	139.44M	10.3K	+2.51%
Mar 31, 2025	STATE STREET CORP	3.43%	758.51K	251.24M	-22.78K	-2.92%
Mar 31, 2025	BLACKROCK, INC.	6.73%	1.49M	492.36M	-7.71K	-0.52%
Mar 31, 2025	VANGUARD GROUP INC	7.65%	1.69M	559.82M	-16.02K	-0.94%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.28%	60.79K	20.14M	579	+0.96%
Mar 31, 2025	BAKER BROS. ADVISORS LP	8.94%	1.97M	654.04M	0	0
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.86%	189.64K	62.81M	-41.81K	-18.06%
Mar 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.87%	191.61K	63.47M	171.65K	+859.96%
Mar 31, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.31%	67.5K	22.36M	56.6K	+519.27%
Mar 31, 2025	WOODLINE PARTNERS LP	1.44%	317.43K	105.14M	8.32K	+2.69%
Mar 31, 2025	UBS GROUP AG	1.46%	321.51K	106.49M	-3.77K	-1.16%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.46%	542.63K	179.74M	-46.13K	-7.84%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.39%	85.09K	28.18M	-75.7K	-47.08%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.43%	94.2K	31.2M	-118K	-55.61%
Mar 31, 2025	INVESCO LTD.	0.6%	132.93K	44.03M	3.86K	+2.99%
Mar 31, 2025	ARTISAN PARTNERS LIMITED PARTNERSHIP	0.62%	137.74K	45.62M	-69.73K	-33.61%
Mar 31, 2025	VICTORY CAPITAL MANAGEMENT INC	0.31%	68.39K	22.65M	-2.25K	-3.18%
Mar 31, 2025	D. E. SHAW & CO., INC.	0.45%	99.01K	32.79M	75.16K	+315.22%
Mar 31, 2025	BIOIMPACT CAPITAL LLC	0.45%	100.42K	33.26M	100.42K	+100.00%
Mar 31, 2025	683 CAPITAL MANAGEMENT, LLC	0.69%	152K	50.35M	-2.5K	-1.62%
Mar 31, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.46%	102.36K	33.9M	-928	-0.90%
Mar 31, 2025	TAO CAPITAL MANAGEMENT LP	0.51%	112.79K	37.36M	-17.74K	-13.59%
Mar 31, 2025	FIERA CAPITAL CORP	0.6%	132.18K	43.78M	24.76K	+23.05%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.68%	151.25K	50.1M	505	+0.34%
Mar 31, 2025	ARROWMARK COLORADO HOLDINGS LLC	0.82%	180.11K	59.66M	-19.56K	-9.80%
Mar 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.94%	207.04K	68.5M	-1.44K	-0.69%
Mar 31, 2025	HOOD RIVER CAPITAL MANAGEMENT LLC	1.1%	243.99K	80.82M	116.16K	+90.86%
Mar 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.3%	65.86K	21.81M	65.86K	+100.00%
Mar 31, 2025	AFFINITY ASSET ADVISORS, LLC	0.36%	80K	26.5M	-2.5K	-3.03%
Mar 31, 2025	POLAR CAPITAL HOLDINGS PLC	0.68%	150.22K	49.76M	12.5K	+9.08%
Mar 31, 2025	AMERICAN CENTURY COMPANIES INC	0.72%	158.31K	52.44M	21.46K	+15.68%
Mar 31, 2025		0.74%	164.4K	54.37M	0	0
Mar 31, 2025	RTW INVESTMENTS, LP	9.02%	1.99M	660.37M	0	0
Mar 31, 2025	AVORO CAPITAL ADVISORS LLC	9.15%	2.02M	669.82M	-6.78K	-0.33%
Mar 31, 2025	PAULSON & CO. INC.	9.5%	2.1M	695.43M	57.52K	+2.82%
Mar 31, 2025	JANUS HENDERSON GROUP PLC	9.99%	2.21M	723.11M	-2.55K	-0.12%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	1.11%	245.96K	81.47M	28.13K	+12.92%
Mar 31, 2025	NORTHERN TRUST CORP	0.68%	150.89K	49.98M	-5K	-3.21%
Mar 31, 2025	JANE STREET GROUP, LLC	1.24%	273.2K	90.49M	-89.3K	-24.63%
Mar 31, 2024	PROPEL BIO MANAGEMENT, LLC	0.22%	43.03K	11.49M	13K	+43.29%
Mar 31, 2024	FRED ALGER MANAGEMENT, LLC	0.32%	64.58K	17.24M	46.48K	+256.83%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.36%	70.71K	18.88M	10.84K	+18.11%
Mar 31, 2024	EMERALD MUTUAL FUND ADVISERS TRUST	0.38%	75.76K	20.23M	36.48K	+92.87%
Mar 31, 2024	INVESCO LTD.	0.41%	80.19K	21.41M	71.53K	+825.79%
Mar 31, 2024	ENSIGN PEAK ADVISORS, INC	0.46%	92.22K	24.63M	30.81K	+50.16%
Mar 31, 2024	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.46%	92.25K	24.48M	30.75K	+49.99%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.46%	91.79K	24.51M	6.69K	+7.86%
Mar 31, 2024	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.47%	93.6K	24.99M	39.49K	+72.99%
Mar 31, 2024	LORD, ABBETT & CO. LLC	0.49%	97.1K	25.93M	97.1K	+100.00%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.49%	97.75K	26.1M	21.88K	+28.84%
Mar 31, 2024	EMERALD ADVISERS, LLC	0.51%	101.62K	27.14M	53.9K	+112.95%
Mar 31, 2024	ALPINVEST PARTNERS B.V.	0.53%	105.74K	28.24M	-105.74K	-50.00%
Mar 31, 2024	RHEOS CAPITAL WORKS INC.	0.55%	110.22K	29.43M	110.22K	+100.00%
Mar 31, 2024	ARTAL GROUP S.A.	0.55%	110.51K	29.51M	110.51K	+100.00%
Mar 31, 2024	CITADEL ADVISORS LLC	0.42%	82K	21.9M	31.3K	+61.74%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.57%	113.11K	30.21M	-1.79K	-1.56%
Mar 31, 2024	AFFINITY ASSET ADVISORS, LLC	0.58%	115K	30.71M	15K	+15.00%
Mar 31, 2024	TWIN TREE MANAGEMENT, LP	0.61%	122.2K	32.63M	122.2K	+100.00%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.62%	122.69K	32.76M	2.48K	+2.06%
Mar 31, 2024	POLAR CAPITAL HOLDINGS PLC	0.63%	125.21K	33.43M	125.21K	+100.00%
Mar 31, 2024	TAO CAPITAL MANAGEMENT LP	0.65%	130.53K	34.86M	0	0
Mar 31, 2024	NORTHERN TRUST CORP	0.66%	131.36K	35.08M	-3.35K	-2.49%
Mar 31, 2024	TCG CROSSOVER MANAGEMENT, LLC	0.75%	149.28K	39.86M	-30.63K	-17.03%
Mar 31, 2024	POINT72 ASSET MANAGEMENT, L.P.	0.47%	93.57K	24.99M	93.57K	+100.00%
Mar 31, 2024	683 CAPITAL MANAGEMENT, LLC	0.89%	177.9K	47.51M	167.9K	+1,679.00%
Mar 31, 2024	PICTET ASSET MANAGEMENT HOLDING SA	0.92%	184.16K	48.43M	13K	+7.59%
Mar 31, 2024	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	0.98%	197K	52.61M	-127.62K	-39.32%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	1.76%	346.86K	92.64M	10.6K	+3.15%
Mar 31, 2024	ARTISAN PARTNERS LIMITED PARTNERSHIP	2.01%	401.71K	107.27M	105.23K	+35.49%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	1.69%	333.8K	89.14M	236K	+241.31%
Mar 31, 2024	VANGUARD GROUP INC	8.45%	1.67M	445.64M	94.06K	+5.97%
Mar 31, 2024	RA CAPITAL MANAGEMENT, L.P.	1.02%	204.5K	54.61M	0	0
Mar 31, 2024	ROCK SPRINGS CAPITAL MANAGEMENT LP	1.43%	285.93K	76.36M	87.76K	+44.29%
Mar 31, 2024	MORGAN STANLEY	1.46%	288.61K	77.07M	136.69K	+89.97%
Mar 31, 2024	STATE STREET CORP	3.16%	624.94K	166.88M	-75.8K	-10.82%
Mar 31, 2024	PRICE T ROWE ASSOCIATES INC /MD/	4.06%	803.21K	214.49M	414.48K	+106.63%
Mar 31, 2024	BLACKROCK INC.	6.13%	1.21M	323.22M	-2.17K	-0.18%
Mar 31, 2024	PAULSON & CO. INC.	8.87%	1.78M	474M	669.26K	+60.53%
Mar 31, 2024	AVORO CAPITAL ADVISORS LLC	9.72%	1.94M	519.24M	55.56K	+2.94%
Mar 31, 2024	SIMPLIFY ASSET MANAGEMENT INC.	0.12%	23.29K	6.22M	9K	+62.96%
Mar 31, 2024	SWISS NATIONAL BANK	0.12%	23.4K	6.25M	2K	+9.35%
Mar 31, 2024	SCHRODER INVESTMENT MANAGEMENT GROUP	0.12%	23.7K	6.33M	5.4K	+29.51%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.14%	27.9K	7.45M	-311.85K	-91.79%
Mar 31, 2024	PFM HEALTH SCIENCES, LP	0.15%	29.97K	8M	29.97K	+100.00%
Mar 31, 2024	CIBC PRIVATE WEALTH GROUP, LLC	0.15%	30.05K	7.68M	30.05K	+100.00%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.16%	30.74K	8.21M	14.66K	+91.19%
Mar 31, 2024	HENNION & WALSH ASSET MANAGEMENT, INC.	0.16%	32.32K	8.63M	5.39K	+20.03%
Mar 31, 2024	CITIGROUP INC	0.17%	32.79K	8.76M	11.47K	+53.78%
Mar 31, 2024	SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)	0.18%	35.11K	9.38M	29.84K	+566.01%
Mar 31, 2024	ROCKEFELLER CAPITAL MANAGEMENT L.P.	0.18%	35.16K	9.39M	2.12K	+6.42%
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	0.18%	35.92K	9.59M	-7.18K	-16.66%
Mar 31, 2024	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.18%	36.5K	9.75M	14K	+62.22%
Mar 31, 2024	CUTLER GROUP LLC / CA	0.16%	32K	763K	6.5K	+25.49%
Mar 31, 2024	GROUP ONE TRADING, L.P.	0.22%	43.17K	11.53M	-148.76K	-77.51%
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.25%	50.33K	13.44B	34.79K	+223.87%
Mar 31, 2024	JPMORGAN CHASE & CO	0.28%	55.4K	14.8M	-3.91K	-6.59%
Mar 31, 2024	UNIVERSITY OF WISCONSIN FOUNDATION	0.29%	56.38K	15.05M	-17.11K	-23.28%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.29%	57.88K	15.46M	-4.3K	-6.91%
Mar 31, 2024	MACQUARIE GROUP LTD	0.3%	58.96K	15.74M	30.46K	+106.87%
Mar 31, 2024	ECOR1 CAPITAL, LLC	0.38%	75K	20.03M	75K	+100.00%
Mar 31, 2024	UBS GROUP AG	0.63%	125.42K	33.49M	37.04K	+41.91%
Mar 31, 2024	ARMISTICE CAPITAL, LLC	0.84%	168K	44.86M	118K	+236.00%
Mar 31, 2024	RTW INVESTMENTS, LP	1.99%	397.05K	106.03M	-418.14K	-51.29%
Mar 31, 2024	PERCEPTIVE ADVISORS LLC	2.15%	429.95K	114.81M	278.8K	+184.45%
Mar 31, 2024	FMR LLC	3.61%	713.91K	190.64M	88.75K	+14.20%
Mar 31, 2024	BAKER BROS. ADVISORS LP	9.85%	1.97M	526.01M	0	0
Mar 31, 2024	JANUS HENDERSON GROUP PLC	13.01%	2.6M	694.53M	-300.77K	-10.36%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.34%	62.18K	14.39M	3.39K	+5.77%
Dec 31, 2023	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.33%	61.51K	14.36M	-767	-1.23%
Dec 31, 2023	JANE STREET GROUP, LLC	1.17%	216.82K	50.17M	113.43K	+109.72%
Dec 31, 2023	ARTISAN PARTNERS LIMITED PARTNERSHIP	1.6%	296.48K	68.6M	16.39K	+5.85%
Dec 31, 2023	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	1.76%	324.62K	75.11M	324.62K	+100.00%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.82%	336.26K	77.81M	39.82K	+13.43%
Dec 31, 2023	ALLIANCEBERNSTEIN L.P.	1.84%	339.75K	78.61M	-21.22K	-5.88%
Dec 31, 2023	PRICE T ROWE ASSOCIATES INC /MD/	2.1%	388.73K	89.95M	218.36K	+128.16%
Dec 31, 2023	FMR LLC	3.38%	625.17K	144.65M	184.79K	+41.96%
Dec 31, 2023	STATE STREET CORP	3.79%	700.74K	162.14M	58.47K	+9.10%
Dec 31, 2023	ENSIGN PEAK ADVISORS, INC	0.33%	61.41K	14.21M	10.37K	+20.30%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.32%	59.87K	13.85M	20.34K	+51.44%
Dec 31, 2023	WELLS FARGO & COMPANY/MN	0.32%	59.79K	13.83M	39.67K	+197.25%
Dec 31, 2023	DEUTSCHE BANK AG\	0.32%	59.4K	13.74M	15.53K	+35.39%
Dec 31, 2023	JPMORGAN CHASE & CO	0.32%	59.31K	13.72M	-39.14K	-39.76%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.62%	114.9K	26.59M	5.4K	+4.93%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.65%	120.21K	27.81M	10.71K	+9.78%
Dec 31, 2023	TAO CAPITAL MANAGEMENT LP	0.71%	130.53K	30.2M	52.87K	+68.08%
Dec 31, 2023	CUTLER GROUP LLC / CA	0.3%	56.2K	746K	-27.3K	-32.69%
Dec 31, 2023	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.29%	54.11K	12.52M	2.42K	+4.68%
Dec 31, 2023	LMR PARTNERS LLP	0.28%	51.89K	12.01M	44.39K	+591.80%
Dec 31, 2023	CITADEL ADVISORS LLC	0.27%	50.7K	11.73M	11.4K	+29.01%
Dec 31, 2023	L1 CAPITAL PTY LTD	0.27%	50.23K	11.62M	1.76K	+3.63%
Dec 31, 2023	ARMISTICE CAPITAL, LLC	0.27%	50K	11.57M	-58K	-53.70%
Dec 31, 2023	JANUS HENDERSON GROUP PLC	15.71%	2.9M	671.51M	-140.61K	-4.62%
Dec 31, 2023	BAKER BROS. ADVISORS LP	10.66%	1.97M	455.77M	424.69K	+27.49%
Dec 31, 2023	AFFINITY ASSET ADVISORS, LLC	0.54%	100K	23.14M	15K	+17.65%
Dec 31, 2023	AVORO CAPITAL ADVISORS LLC	10.22%	1.89M	437.05M	333.89K	+21.47%
Dec 31, 2023	VANGUARD GROUP INC	8.52%	1.57M	364.36M	1.4K	+0.09%
Dec 31, 2023	BLACKROCK INC.	6.56%	1.21M	280.56M	179.84K	+17.41%
Dec 31, 2023	PAULSON & CO. INC.	5.98%	1.11M	255.85M	605.74K	+121.15%
Dec 31, 2023	UBS GROUP AG	0.48%	88.38K	20.45M	32.19K	+57.30%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.46%	85.1K	19.69M	8.69K	+11.37%
Dec 31, 2023	NORTHERN TRUST CORP	0.73%	134.71K	31.17M	11.06K	+8.94%
Dec 31, 2023	NORGES BANK	0.79%	145.59K	33.69M	145.59K	+100.00%
Dec 31, 2023	PERCEPTIVE ADVISORS LLC	0.82%	151.15K	34.97M	26.51K	+21.27%
Dec 31, 2023	MORGAN STANLEY	0.82%	151.92K	35.15M	-19.86K	-11.56%
Dec 31, 2023	RTW INVESTMENTS, LP	4.41%	815.19K	188.62M	505.71K	+163.40%
Dec 31, 2023		0.93%	171.17K	39.6M	59.74K	+53.61%
Dec 31, 2023	TCG CROSSOVER MANAGEMENT, LLC	0.97%	179.92K	41.63M	0	0
Dec 31, 2023	GROUP ONE TRADING, L.P.	1.04%	191.93K	44.41B	116.24K	+153.58%
Dec 31, 2023	ROCK SPRINGS CAPITAL MANAGEMENT LP	1.07%	198.17K	45.85M	1.8K	+0.92%
Dec 31, 2023	RA CAPITAL MANAGEMENT, L.P.	1.11%	204.5K	47.32M	0	0
Dec 31, 2023	ALPINVEST PARTNERS B.V.	1.14%	211.49K	48.93M	211.49K	+100.00%
Dec 31, 2023	SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC	0.45%	82.29K	19.04M	82.29K	+100.00%
Dec 31, 2023	AMERICAN CENTURY COMPANIES INC	0.41%	75.87K	17.56M	12.26K	+19.28%
Dec 31, 2023	UNIVERSITY OF WISCONSIN FOUNDATION	0.4%	73.49K	17M	33.35K	+83.11%
Dec 31, 2023	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	0.38%	69.41K	16.06M	69.41K	+100.00%

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Sep 11, 2026	SIBOLD WILLIAM JOHN	SALE	546.38	120	65.57K	197.75K
Sep 09, 2026	SIBOLD WILLIAM JOHN	SALE	542.55	160	86.81K	202.97K
Aug 17, 2026	KELLEY SHANNON T	SALE	514.97	664	341.94K	11.47K
Jul 20, 2026	SIBOLD WILLIAM JOHN	SALE	555.05	280	155.41K	209.33K
Jun 01, 2026	SOERGEL DAVID	SALE	495.74	1.04K	516.56K	10.03K
May 22, 2026	LEVY RICHARD S	SALE	519.98	80	41.6K	22.02K
May 18, 2026	SOERGEL DAVID	SALE	515.90	844	435.42K	11.08K
Mar 06, 2026	TAUB REBECCA	SALE	431.94	491	212.08K	452.21K
Mar 06, 2026	DIER MARDI	SALE	437.65	40	17.51K	12.49K
Mar 06, 2026	SIBOLD WILLIAM JOHN	SALE	431.94	1.66K	718.32K	161.83K
Mar 06, 2026	KELLEY SHANNON T	SALE	431.94	360	155.5K	12.14K
Mar 06, 2026	HUNTSMAN CAROLE	SALE	431.94	419	180.98K	12.69K
Mar 02, 2026	DIER MARDI	SALE	427.21	1.18K	505.39K	9.26K
Jan 26, 2026	TAUB REBECCA	SALE	492.42	647	318.6K	452.7K
Jan 26, 2026	SIBOLD WILLIAM JOHN	SALE	492.42	1.58K	776.55K	148.5K
Jan 26, 2026	HUNTSMAN CAROLE	SALE	494.59	570	281.92K	9.12K
Jan 20, 2026	TAUB REBECCA	SALE	490.77	2.24K	1.1M	453.35K
Jan 20, 2026	KELLEY SHANNON T	SALE	501.40	429	215.1K	8.48K
Jan 09, 2026	TAUB REBECCA	SALE	542.72	400	217.09K	455.59K
Jan 09, 2026	FRIEDMAN PAUL A	SALE	545.79	40	21.83K	187.16K
Dec 10, 2025	FRIEDMAN PAUL A	SALE	555.39	160	88.86K	187.16K
Dec 10, 2025	TAUB REBECCA	SALE	555.39	200	111.08K	461.04K
Dec 04, 2025	SIBOLD WILLIAM JOHN	SALE	575.34	2.4K	1.38M	150.07K
Dec 02, 2025	DIER MARDI	SALE	596.18	80	47.69K	10.44K
Nov 21, 2025	HUNTSMAN CAROLE	SALE	564.57	80	45.17K	10.03K
Nov 13, 2025	LEVY RICHARD S	SALE	530.21	40	21.21K	21.2K
Nov 05, 2025	BATE KENNETH	SALE	490.98	30	14.73K	2.63K
Sep 09, 2025	SIBOLD WILLIAM JOHN	SALE	445.63	7.28K	3.24M	102.47K
Aug 21, 2025	SIBOLD WILLIAM JOHN	SALE	401.00	1.13K	453.53K	109.75K
Aug 20, 2025	BAKER BROS. ADVISORS LP	PURCHASE	380.44	480	182.61K	198.24K
Aug 18, 2025	KELLEY SHANNON T	SALE	376.62	42	15.82K	9.17K
Aug 18, 2025	BAKER BROS. ADVISORS LP	PURCHASE	353.88	177	62.64K	189.01K
Aug 15, 2025	BATE KENNETH	SALE	368.56	896	330.23K	2.63K
Aug 13, 2025	FRIEDMAN PAUL A	SALE	374.38	4.16K	1.56M	187.16K
Aug 12, 2025	TAUB REBECCA	SALE	359.71	700	251.8K	461.04K
Aug 12, 2025	FRIEDMAN PAUL A	SALE	359.81	600	215.89K	187.16K
Aug 11, 2025	FRIEDMAN PAUL A	SALE	351.04	300	105.31K	187.16K
Aug 11, 2025	TAUB REBECCA	SALE	351.02	220	77.22K	461.04K
Jul 18, 2025	TAUB REBECCA	SALE	350.00	1K	350.01K	461.04K
Jul 18, 2025	FRIEDMAN PAUL A	SALE	350.03	1.4K	490.04K	187.16K
Jul 17, 2025	TAUB REBECCA	SALE	351.50	600	210.9K	461.04K
Jul 17, 2025	FRIEDMAN PAUL A	SALE	351.57	700	246.1K	187.16K
Jul 16, 2025	FRIEDMAN PAUL A	SALE	356.62	1.2K	427.94K	187.16K
Jul 16, 2025	TAUB REBECCA	SALE	356.52	1.38K	492K	461.04K
Mar 13, 2025	CRAVES FRED B	SALE	330.23	75	24.77K	350.08K
Mar 12, 2025	CRAVES FRED B	SALE	334.97	200	66.99K	350.08K
Mar 10, 2025	DIER MARDI	SALE	323.04	258	83.34K	10.44K
Mar 05, 2025	WALTERMIRE ROBERT E.	SALE	344.76	1.41K	486.8K	3.73K
Mar 03, 2025	DIER MARDI	SALE	323.54	774	250.42K	6.91K
Mar 03, 2025	KELLEY SHANNON T	SALE	335.00	415	139.03K	7.29K
Mar 03, 2025	HUNTSMAN CAROLE	SALE	335.00	563	188.61K	8.6K
Feb 27, 2025	DALY JAMES M	SALE	348.94	770	268.69K	1.91K
Feb 27, 2025	BATE KENNETH	SALE	360.07	216	77.77K	1.91K
Jan 24, 2025	HUNTSMAN CAROLE	SALE	335.24	347	116.33K	10.44K
Jan 24, 2025	TAUB REBECCA	SALE	335.24	648	217.24K	456.66K
Jan 24, 2025	SIBOLD WILLIAM JOHN	SALE	335.24	1.58K	531.02K	54.3K
Jan 24, 2025	WALTERMIRE ROBERT E.	SALE	335.24	103	34.53K	4.96K
Jan 17, 2025	KELLEY SHANNON T	SALE	273.41	277	75.73K	7.71K
Jan 17, 2025	WALTERMIRE ROBERT E.	SALE	273.41	442	120.85K	5.06K
Jan 17, 2025	TAUB REBECCA	SALE	273.41	1.69K	461.79K	457.31K
Dec 03, 2024	CRAVES FRED B	SALE	315.90	520	164.27K	11K
Nov 25, 2024	CRAVES FRED B	SALE	350.71	1.2K	420.86K	14.6K
Nov 21, 2024	HUNTSMAN CAROLE	SALE	316.92	688	218.04K	10.79K
Nov 07, 2024	LEVY RICHARD S	SALE	350.00	5K	1.75M	11.01K
Nov 01, 2024	LEVY RICHARD S	SALE	304.29	300	91.29K	11.01K
Sep 09, 2024	SIBOLD WILLIAM JOHN	SALE	243.83	6.36K	1.55M	55.89K
Jun 14, 2024	WALTERMIRE ROBERT E.	SALE	280.00	1.9K	532K	5.5K
Jun 12, 2024	WALTERMIRE ROBERT E.	SALE	285.00	2K	570K	5.5K
May 21, 2024	WALTERMIRE ROBERT E.	SALE	231.34	1.04K	239.67K	5.5K
May 14, 2024	CRAVES FRED B	SALE	219.90	100	21.99K	413.36K
Apr 08, 2024	TAUB REBECCA	SALE	248.58	200	49.72K	459K
Apr 08, 2024	FRIEDMAN PAUL A	SALE	248.59	4.87K	1.21M	185.74K
Apr 05, 2024	FRIEDMAN PAUL A	SALE	245.92	444	109.19K	185.74K
Apr 05, 2024	TAUB REBECCA	SALE	245.53	5.28K	1.3M	459K
Apr 04, 2024	FRIEDMAN PAUL A	SALE	248.43	200	49.69K	185.74K
Apr 04, 2024	TAUB REBECCA	SALE	248.23	100	24.82K	459K
Apr 03, 2024	TAUB REBECCA	SALE	246.32	2.09K	514.57K	459K
Apr 03, 2024	FRIEDMAN PAUL A	SALE	246.31	1.82K	448.53K	185.74K
Apr 02, 2024	BATE KENNETH	SALE	249.05	7	1.74K	1.2K
Apr 02, 2024	DALY JAMES M	SALE	244.89	2.99K	732.48K	2K
Apr 01, 2024	LEVY RICHARD S	SALE	267.07	300	80.12K	10.3K
Apr 01, 2024	DALY JAMES M	SALE	265.49	500	132.74K	1.47K
Apr 01, 2024	BATE KENNETH	SALE	266.91	274	73.13K	1.2K
Mar 21, 2024	BAKER BROS. ADVISORS LP	PURCHASE	0.00	86.74K	8.67	212.19K
Dec 15, 2023	WALTERMIRE ROBERT E.	SALE	241.00	1K	241K	5.67K
Dec 14, 2023	BAKER BROS. ADVISORS LP	PURCHASE	227.86	11.6K	2.64M	1.79M
Dec 14, 2023	WALTERMIRE ROBERT E.	SALE	232.00	1K	232K	5.67K
Dec 13, 2023	BAKER BROS. ADVISORS LP	PURCHASE	224.91	5.59K	1.26M	1.77M
Dec 13, 2023	WALTERMIRE ROBERT E.	SALE	225.00	1.5K	337.5K	6.67K
Dec 12, 2023	BAKER BROS. ADVISORS LP	PURCHASE	221.24	3.86K	853.33K	1.7M
Dec 12, 2023	WALTERMIRE ROBERT E.	SALE	216.00	500	108K	6.47K
Dec 05, 2023	LYNCH BRIAN JOSEPH	SALE	227.33	1K	227.33K	15K
Dec 04, 2023	LYNCH BRIAN JOSEPH	SALE	215.73	800	172.58K	16K
Nov 30, 2023	LYNCH BRIAN JOSEPH	SALE	204.00	1K	204K	17K
Nov 29, 2023	LYNCH BRIAN JOSEPH	SALE	198.40	1K	198.4K	18K
Nov 21, 2023	BAKER BROS. ADVISORS LP	PURCHASE	190.14	7.92K	1.51M	1.67M
Nov 20, 2023	BAKER BROS. ADVISORS LP	PURCHASE	189.70	3.02K	573.27K	1.61M
Nov 17, 2023	BAKER BROS. ADVISORS LP	PURCHASE	175.82	10.72K	1.88M	1.59M

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES3.19K7

NET SHARES-3.19K7

SHARES HELD664.64K7

% NET SHARES-100.48%0%

Frequently Asked Questions