How many institutions own ZYME stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own ZYME shares is 247, representing 101.19% of the company's common stock.

Who are the major shareholders selling Zymeworks Inc. stock?

WELLS FARGO & COMPANY/MN, in the last quarter, reduced its stake in ZYME by -8.97% restricting it's holding to 189.64 thousand shares of worth nearly $4.75M. UBS ASSET MANAGEMENT AMERICAS INC also lessened -0.27% of the ZYME shares from its portfolio, reducing its holding to 319.39 thousand shares of worth $8.00M. DEUTSCHE BANK AG\ also shunned ZYME shares holding by -42.27% last quarter which brought its holding to 921.25 thousand shares worth $23.07M.

Investors who are buying ZYME stock?

As per its latest 13F filing, ROYCE & ASSOCIATES LP increased its stake in ZYME by 100% in the last quarter. The institutional holder raised its holding to 299.2 thousand shares having worth more than $7.49M. MAN GROUP PLC also added 152.12% more shares of ZYME to its portfolio, raising its holding to 189.89 thousand shares of worth $4.75M. PANAGORA ASSET MANAGEMENT INC also increased its ZYME shares holding by 164.06% which brought its holding to 206.85 thousand shares worth $5.18M.

ZYME's major insiders: who are they?

The insider with the most stakes in ZYME is EcoR1 Capital, LLC , at the company. Additionally, ZYME stock is highly held by 10 percent owner Redmile Group, LLC and 10 percent owner LILLY ELI & CO among others.

Did an insider recently sell ZYME stock?

Company executives, directors, and other insiders own 0.19% percent of Zymeworks Inc.'s stock. Within the last six months, there have been 8 transaction(s) in which ZYME insiders have sold stock, totaling 145.43K shares. Insiders that have sold shares include MOORE PAUL ANDREW, HOLLYWOOD MARK, and GALBRAITH KENNETH.

Which insider recently purchased ZYME stock?

There have been 0 transaction(s) during the past 6-months in which Zymeworks Inc. insiders have bought stock, totalling 0 shares

How much of ZYME does insiders own?

Around 776.09K Zymeworks Inc. shares are held by insiders, which represents about 0.19% of ZYME stock.

Who is the insider with the largest stake?

ZYME , EcoR1 Capital, LLC holds the largest portfolio of the company's shares. ZYME shares owned by EcoR1 total nearly 17.88 million.

Which institution holds the most shares in ZYME?

ROYCE & ASSOCIATES LP is the largest institutional owner in ZYME which holds 299.2 thousand shares worth $7.49M or 0.4% of the total ZYME shares outstanding followed by WELLS FARGO & COMPANY/MN with ownership of 189.64 thousand shares representing 0.25% of the ZYME ownership. MAN GROUP PLC is the third largest stakeholder with 189.89 thousand shares or 0.25% of the ownership worth more than $4.75M.

Is Zymeworks Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the ZYME is concerned, it is a stock which is optionable.

Is there a short position on ZYME's shares?

Number of ZYME shares short is null. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding ZYME shares are there?

As of today, null shares of ZYME are outstanding.

Is there many float in ZYME stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, ZYME has null shares in float.

ZYME short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for ZYME is null.

Zymeworks (ZYME) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding SharesN/A

Short Percent Of FloatN/A

Shares OutstandingN/A

Shares FloatN/A

Shares ShortN/A

Short RatioN/A

N/A

Short % of Float

N/A

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

0.19% Percentage of Shares held by All Insiders

101.19% Percentage of Shares held by All Institutions

101.38% Percentage of Float held by Institutions

247

Number of Institutions Holding Shares

Institutional Ownership

About 101.19% of ZYME shares are held by financial institutions. ROYCE & ASSOCIATES LP is the top corporate investor, holding 299.2K shares valued at $7.49M. A 0.4% stake in Zymeworks Inc. is owned by the company. WELLS FARGO & COMPANY/MN owns 189.64K shares valued at $4.75M, which translates its holding of 0.25% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Mar 31, 2026	ROYCE & ASSOCIATES LP	0.4%	299.2K	7.49M	299.2K	+100.00%
Mar 31, 2026	WELLS FARGO & COMPANY/MN	0.25%	189.64K	4.75M	-18.68K	-8.97%
Mar 31, 2026	MAN GROUP PLC	0.25%	189.89K	4.75M	114.57K	+152.12%
Mar 31, 2026	PANAGORA ASSET MANAGEMENT INC	0.27%	206.85K	5.18M	128.52K	+164.06%
Mar 31, 2026	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.29%	216.4K	5.42M	22.3K	+11.49%
Mar 31, 2026	JANE STREET GROUP, LLC	0.3%	226.97K	5.68M	156.52K	+222.19%
Mar 31, 2026	D. E. SHAW & CO., INC.	0.31%	235.62K	5.9M	11.84K	+5.29%
Mar 31, 2026	BANK OF AMERICA CORP /DE/	0.31%	236.75K	5.93M	147.23K	+164.46%
Mar 31, 2026	PICTON MAHONEY ASSET MANAGEMENT	0.34%	256.69K	6.43M	11.89K	+4.86%
Mar 31, 2026	UBS ASSET MANAGEMENT AMERICAS INC	0.42%	319.39K	8M	-876	-0.27%
Mar 31, 2026	NORTHERN TRUST CORP	0.43%	320.21K	8.02M	12.23K	+3.97%
Mar 31, 2026	HILLSDALE INVESTMENT MANAGEMENT INC.	0.46%	345.62K	8.65M	107.7K	+45.27%
Mar 31, 2026	REDMILE GROUP, LLC	0.65%	491.65K	12.31M	0	0
Mar 31, 2026		0.66%	499.88K	12.52M	499.88K	+100.00%
Mar 31, 2026	QUBE RESEARCH & TECHNOLOGIES LTD	0.68%	511.94K	12.82M	37.65K	+7.94%
Mar 31, 2026	PROSIGHT MANAGEMENT, LP	0.72%	539.05K	13.5M	8.66K	+1.63%
Mar 31, 2026	BIOIMPACT CAPITAL LLC	0.75%	565.25K	14.15M	565.25K	+100.00%
Mar 31, 2026	GOLDMAN SACHS GROUP INC	0.8%	599.49K	15.01M	179.28K	+42.66%
Mar 31, 2026	NUVEEN, LLC	0.87%	651.66K	16.32M	3.34K	+0.51%
Mar 31, 2026	GEODE CAPITAL MANAGEMENT, LLC	0.88%	659.94K	16.52M	11.97K	+1.85%
Mar 31, 2026	ASSENAGON ASSET MANAGEMENT S.A.	0.97%	727.99K	18.23M	80.61K	+12.45%
Mar 31, 2026	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	0.99%	743.9K	18.63M	43.9K	+6.27%
Mar 31, 2026	DEUTSCHE BANK AG\	1.22%	921.25K	23.07M	-674.58K	-42.27%
Mar 31, 2026	CAPRICORN FUND MANAGERS LTD	1.34%	1.01M	25.22M	-15.63K	-1.53%
Mar 31, 2026	STATE STREET CORP	1.34%	1.01M	25.33M	-25.87K	-2.49%
Mar 31, 2026	MARTINGALE ASSET MANAGEMENT L P	0.04%	32.76K	820.41K	32.76K	+100.00%
Mar 31, 2026	PERSISTENT ASSET PARTNERS LTD	0.05%	35.94K	899.81K	28.59K	+389.18%
Mar 31, 2026	HIGHTOWER ADVISORS, LLC	0.05%	36.26K	908K	36.26K	+100.00%
Mar 31, 2026	O'SHAUGHNESSY ASSET MANAGEMENT, LLC	0.05%	37.13K	929.71K	-5.92K	-13.76%
Mar 31, 2026	HSBC HOLDINGS PLC	0.05%	37.78K	940.08K	19.91K	+111.42%
Mar 31, 2026	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.05%	37.92K	949.49K	37.92K	+100.00%
Mar 31, 2026	LOS ANGELES CAPITAL MANAGEMENT LLC	0.05%	39.75K	995.34K	39.36K	+10,171.32%
Mar 31, 2026	ENVESTNET ASSET MANAGEMENT INC	0.05%	40.42K	1.01M	-393	-0.96%
Mar 31, 2026	NORTH GROWTH MANAGEMENT LTD.	0.06%	46K	1.14M	1K	+2.22%
Mar 31, 2026	RUSSELL INVESTMENTS GROUP, LTD.	0.06%	47.45K	1.19M	-10.9K	-18.68%
Mar 31, 2026	DLD ASSET MANAGEMENT, LP	0.07%	53K	1.33M	-9K	-14.52%
Mar 31, 2026	DANA INVESTMENT ADVISORS, INC.	0.07%	56.11K	1.4M	7.79K	+16.12%
Mar 31, 2026	SWISS NATIONAL BANK	0.1%	74.2K	1.86M	0	0
Mar 31, 2026	RHUMBLINE ADVISERS	0.1%	75.4K	1.89M	-99	-0.13%
Mar 31, 2026	STIFEL FINANCIAL CORP	0.1%	76.76K	1.92M	909	+1.20%
Mar 31, 2026	FRANKLIN RESOURCES INC	0.1%	77.66K	1.94M	18.67K	+31.65%
Mar 31, 2026	PRINCIPAL FINANCIAL GROUP INC	0.1%	78.55K	1.97M	78.55K	+100.00%
Mar 31, 2026	MACKENZIE FINANCIAL CORP	0.11%	82.73K	2.07M	37.27K	+81.98%
Mar 31, 2026	VANGUARD FIDUCIARY TRUST CO	0.11%	84.4K	2.11M	84.4K	+100.00%
Mar 31, 2026	KORNITZER CAPITAL MANAGEMENT INC /KS	0.12%	88.8K	2.22M	0	0
Mar 31, 2026	FISHER ASSET MANAGEMENT, LLC	0.13%	101.44K	2.54M	33.24K	+48.74%
Mar 31, 2026	TEMA ETFS LLC	0.14%	104.93K	2.63M	28.96K	+38.11%
Mar 31, 2026	PLATINUM INVESTMENT MANAGEMENT LTD	0.14%	105.18K	2.63M	0	0
Mar 31, 2026	JPMORGAN CHASE & CO	0.15%	114.07K	2.76M	79.06K	+225.85%
Mar 31, 2026	CITIGROUP INC	0.15%	114.33K	2.86M	3.12K	+2.81%
Mar 31, 2026	BANK OF NEW YORK MELLON CORP	0.16%	124.11K	3.11M	-4.03K	-3.14%
Mar 31, 2026	BLACKROCK, INC.	6.04%	4.55M	114.03M	-41.66K	-0.91%
Mar 31, 2026	INVESCO LTD.	0.17%	125.63K	3.15M	-131.95K	-51.23%
Mar 31, 2026	WELLINGTON MANAGEMENT GROUP LLP	0.18%	138.69K	3.47M	-43.02K	-23.67%
Mar 31, 2026	DIADEMA PARTNERS LP	0.19%	142.13K	3.56M	142.13K	+100.00%
Mar 31, 2026	HRT FINANCIAL LP	0.32%	237.89K	5.96M	116.83K	+96.50%
Mar 31, 2026	GRANAHAN INVESTMENT MANAGEMENT, LLC	0.33%	250.77K	6.28M	26.37K	+11.75%
Mar 31, 2026	FMR LLC	0.89%	667.15K	16.71M	107.07K	+19.12%
Mar 31, 2026	NEXTECH INVEST, LTD.	1.48%	1.11M	27.89M	0	0
Mar 31, 2026	DIMENSIONAL FUND ADVISORS LP	1.51%	1.14M	28.52M	-20.08K	-1.73%
Mar 31, 2026	CITADEL ADVISORS LLC	1.53%	1.15M	28.8M	894.67K	+350.37%
Mar 31, 2026	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	2.53%	1.91M	47.78M	85.99K	+4.72%
Mar 31, 2026	MORGAN STANLEY	3.29%	2.48M	62.11M	-112.51K	-4.34%
Mar 31, 2026	PERCEPTIVE ADVISORS LLC	4.66%	3.51M	87.89M	248.23K	+7.61%
Mar 31, 2026	BVF INC/IL	4.96%	3.73M	93.5M	-204.5K	-5.19%
Mar 31, 2026	RUBRIC CAPITAL MANAGEMENT LP	9.29%	7M	175.28M	1.25M	+21.74%
Mar 31, 2026	ECOR1 CAPITAL, LLC	30.49%	22.97M	575.18M	0	0
Mar 31, 2026	SUMMITTX CAPITAL, L.P.	0.43%	321.43K	8.05M	97.16K	+43.32%
Mar 31, 2026	SILVERCREST ASSET MANAGEMENT GROUP LLC	0.22%	163.65K	4.1M	-18.14K	-9.98%
Mar 31, 2026	XTX TOPCO LTD	0.19%	143.88K	3.6M	50.41K	+53.94%
Mar 31, 2026	RAYMOND JAMES FINANCIAL INC	0.23%	176.41K	4.42M	-11.27K	-6.01%
Mar 31, 2026	FEDERATED HERMES, INC.	0.24%	182.41K	4.57M	29.72K	+19.47%
Mar 31, 2026	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.25%	185.12K	4.64M	-35.79K	-16.20%
Mar 31, 2026	KENNEDY CAPITAL MANAGEMENT LLC	0.2%	148.23K	3.71M	2.69K	+1.85%
Mar 31, 2026	UBS GROUP AG	0.23%	171.78K	4.3M	-107.08K	-38.40%
Dec 31, 2025	XTX TOPCO LTD	0.12%	93.47K	2.46M	93.47K	+100.00%
Dec 31, 2025	ECOR1 CAPITAL, LLC	30.32%	22.97M	604.81M	0	0
Dec 31, 2025	UBS GROUP AG	0.37%	278.85K	7.34M	227.01K	+437.90%
Dec 31, 2025	FISHER ASSET MANAGEMENT, LLC	0.09%	68.2K	1.8M	-3.78K	-5.25%
Dec 31, 2025	PENSERRA CAPITAL MANAGEMENT LLC	0.08%	60.15K	1.58M	60.15K	+100.00%
Dec 31, 2025	FRANKLIN RESOURCES INC	0.08%	58.99K	1.55M	25.17K	+74.41%
Dec 31, 2025	ROYAL BANK OF CANADA	0.07%	55.06K	1.45M	-2.87K	-4.95%
Dec 31, 2025	DANA INVESTMENT ADVISORS, INC.	0.06%	48.32K	1.27M	48.32K	+100.00%
Dec 31, 2025	SIMPLEX TRADING, LLC	0.06%	48.04K	1.26M	19.28K	+67.03%
Dec 31, 2025	O'SHAUGHNESSY ASSET MANAGEMENT, LLC	0.06%	43.05K	1.13M	1.28K	+3.07%
Dec 31, 2025	ENVESTNET ASSET MANAGEMENT INC	0.05%	40.81K	1.07M	26.24K	+180.03%
Dec 31, 2025	JPMORGAN CHASE & CO	0.05%	35.01K	921.76K	1.12K	+3.32%
Dec 31, 2025	RUBRIC CAPITAL MANAGEMENT LP	7.59%	5.75M	151.4M	1.04M	+22.07%
Dec 31, 2025	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	2.4%	1.82M	47.98M	1.82M	+100.00%
Dec 31, 2025	JUPITER ASSET MANAGEMENT LTD	0.17%	125.51K	3.3M	-225.15K	-64.21%
Dec 31, 2025	HRT FINANCIAL LP	0.16%	121.06K	3.19M	52.6K	+76.84%
Dec 31, 2025	CITIGROUP INC	0.15%	111.21K	2.93M	-6.6K	-5.60%
Dec 31, 2025	PLATINUM INVESTMENT MANAGEMENT LTD	0.14%	105.18K	2.77M	-19.6K	-15.71%
Dec 31, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.13%	100K	2.63M	100K	+100.00%
Dec 31, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.13%	97.91K	2.6M	-63.58K	-39.37%
Dec 31, 2025	AQR CAPITAL MANAGEMENT LLC	0.12%	91.08K	2.4M	-61.56K	-40.33%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	0.12%	89.52K	2.36B	14.2K	+18.85%
Dec 31, 2025	KORNITZER CAPITAL MANAGEMENT INC /KS	0.12%	88.8K	2.34M	88.8K	+100.00%
Dec 31, 2025	BARCLAYS PLC	0.11%	79.97K	2.11M	-119.06K	-59.82%
Dec 31, 2025	PANAGORA ASSET MANAGEMENT INC	0.1%	78.34K	2.06M	-27.74K	-26.15%
Dec 31, 2025	TEMA ETFS LLC	0.1%	75.98K	2M	12.31K	+19.34%
Dec 31, 2025	STIFEL FINANCIAL CORP	0.1%	75.85K	2M	3.32K	+4.57%
Dec 31, 2025	RHUMBLINE ADVISERS	0.1%	75.5K	1.99B	-10.4K	-12.11%
Dec 31, 2025	SWISS NATIONAL BANK	0.1%	74.2K	1.95M	1.1K	+1.50%
Dec 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.1%	73.63K	1.97M	73.63K	+100.00%
Dec 31, 2025	NORTHERN TRUST CORP	0.41%	307.98K	8.11M	-40.27K	-11.56%
Dec 31, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.38%	288.57K	7.6M	180.78K	+167.72%
Dec 31, 2025	DIADEMA PARTNERS LP	0.32%	240.6K	6.33M	44.1K	+22.44%
Dec 31, 2025	GRANAHAN INVESTMENT MANAGEMENT, LLC	0.3%	224.41K	5.91M	-120.92K	-35.02%
Dec 31, 2025	SUMMITTX CAPITAL, L.P.	0.3%	224.27K	5.9M	224.27K	+100.00%
Dec 31, 2025	D. E. SHAW & CO., INC.	0.3%	223.79K	5.89M	96.86K	+76.32%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.27%	208.31K	5.48M	31.68K	+17.93%
Dec 31, 2025	BVF INC/IL	5.2%	3.94M	103.7M	0	0
Dec 31, 2025	PERCEPTIVE ADVISORS LLC	4.31%	3.26M	85.88M	1.17M	+56.02%
Dec 31, 2025	NEXTECH INVEST, LTD.	1.47%	1.11M	29.33M	0	0
Dec 31, 2025	VESTAL POINT CAPITAL, LP	1.14%	865K	22.78M	-900K	-50.99%
Dec 31, 2025	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	0.92%	700K	18.43M	386.25K	+123.11%
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.23%	176.09K	4.64M	124.03K	+238.28%
Dec 31, 2025	RAYMOND JAMES FINANCIAL INC	0.25%	187.69K	4.94M	64.82K	+52.75%
Dec 31, 2025	SILVERCREST ASSET MANAGEMENT GROUP LLC	0.24%	181.79K	4.79M	-91.01K	-33.36%
Dec 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.24%	181.71K	4.78M	13.02K	+7.72%
Dec 31, 2025	FEDERATED HERMES, INC.	0.2%	152.69K	4.02M	-30.16K	-16.49%
Dec 31, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.19%	145.53K	3.83M	-906	-0.62%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.17%	128.13K	3.37M	-9.42K	-6.85%
Dec 31, 2025	BLACKROCK, INC.	6.07%	4.6M	121M	606.02K	+15.19%
Dec 31, 2025	MORGAN STANLEY	3.42%	2.59M	68.28M	-1.39M	-34.92%
Dec 31, 2025	VANGUARD GROUP INC	3.07%	2.33M	61.32M	174.29K	+8.09%
Dec 31, 2025	SIREN, L.L.C.	2.22%	1.68M	44.24M	1.68M	+100.00%
Dec 31, 2025	DEUTSCHE BANK AG\	2.11%	1.6M	42.02M	50.94K	+3.30%
Dec 31, 2025	DIMENSIONAL FUND ADVISORS LP	1.53%	1.16M	30.52M	-31.62K	-2.66%
Dec 31, 2025	STATE STREET CORP	1.37%	1.04M	27.32M	-43.55K	-4.03%
Dec 31, 2025	CAPRICORN FUND MANAGERS LTD	1.35%	1.02M	26.93M	1.02M	+100.00%
Dec 31, 2025	NUVEEN, LLC	0.86%	648.33K	17.07M	82.94K	+14.67%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.86%	647.97K	17.06M	-30.67K	-4.52%
Dec 31, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.85%	647.37K	17.05M	-679.4K	-51.21%
Dec 31, 2025	PROSIGHT MANAGEMENT, LP	0.7%	530.39K	13.97M	-219.22K	-29.24%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	0.55%	420.21K	11.06M	-23.32K	-5.26%
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	0.5%	381.62K	10.05M	-723.19K	-65.46%
Dec 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.42%	320.26K	8.43M	-1.39M	-81.28%
Dec 31, 2025	CITADEL ADVISORS LLC	0.34%	255.35K	6.72M	48.49K	+23.44%
Dec 31, 2025	PICTON MAHONEY ASSET MANAGEMENT	0.32%	244.8K	6.45M	38.48K	+18.65%
Dec 31, 2025	JANE STREET GROUP, LLC	0.09%	70.45K	1.85B	-74.76K	-51.49%
Dec 31, 2025	HILLSDALE INVESTMENT MANAGEMENT INC.	0.31%	237.92K	6.26M	21.5K	+9.93%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.29%	220.91K	5.82M	27.55K	+14.25%
Dec 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.29%	220.88K	5.82M	-210.82K	-48.84%
Dec 31, 2025	CAMPBELL & CO INVESTMENT ADVISER LLC	0.04%	33.59K	884.37K	1.1K	+3.37%
Dec 31, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.04%	32.82K	864.02K	2.38K	+7.83%
Dec 31, 2025	LEGAL & GENERAL GROUP PLC	0.04%	32.15K	846.48K	3.78K	+13.32%
Dec 31, 2025		0.04%	32K	855.68K	32K	+100.00%
Dec 31, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	28.63K	753.83K	-4.68K	-14.05%
Dec 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.88%	663.55K	17.47M	99.55K	+17.65%
Dec 31, 2025	FMR LLC	0.74%	560.09K	14.75M	556.57K	+15,838.70%
Dec 31, 2025	REDMILE GROUP, LLC	0.65%	491.65K	12.95M	-3.21M	-86.73%
Dec 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.63%	474.29K	12.49M	219.29K	+85.99%
Dec 31, 2025	ALGERT GLOBAL LLC	0.56%	423.65K	11.16M	215.72K	+103.75%
Dec 31, 2025	INVESCO LTD.	0.34%	257.58K	6.78M	163.92K	+175.02%
Sep 30, 2025	JPMORGAN CHASE & CO	0.05%	33.88K	578.74K	-407.81K	-92.33%
Sep 30, 2025	FRANKLIN RESOURCES INC	0.04%	33.82K	577.66K	33.82K	+100.00%
Sep 30, 2025	PRUDENTIAL FINANCIAL INC	0.04%	33.39K	570.3K	-11.58K	-25.74%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	33.31K	568.92K	0	0
Sep 30, 2025	CAMPBELL & CO INVESTMENT ADVISER LLC	0.04%	32.49K	554.98K	17.51K	+116.84%
Sep 30, 2025	COMMONWEALTH EQUITY SERVICES, LLC	0.04%	31.24K	534K	-933	-2.90%
Sep 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.04%	30.43K	519.78K	16.13K	+112.81%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.57%	431.7K	7.37M	-101.6K	-19.05%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	0.59%	443.53K	7.58M	14.67K	+3.42%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.75%	564K	9.63M	88K	+18.49%
Sep 30, 2025	NUVEEN, LLC	0.75%	565.39K	9.66M	-89.53K	-13.67%
Sep 30, 2025	PICTON MAHONEY ASSET MANAGEMENT	0.27%	206.32K	3.52M	-1.28K	-0.62%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.26%	193.36K	3.3M	69.16K	+55.68%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.9%	678.64K	11.59M	-26.73K	-3.79%
Sep 30, 2025	PROSIGHT MANAGEMENT, LP	1%	749.61K	12.8M	-560.29K	-42.77%
Sep 30, 2025	STATE STREET CORP	1.44%	1.08M	18.47M	-7.27K	-0.67%
Sep 30, 2025	TANG CAPITAL MANAGEMENT LLC	1.46%	1.1M	18.79M	0	0
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	1.47%	1.1M	18.87M	988.71K	+851.59%
Sep 30, 2025	NEXTECH INVEST, LTD.	1.48%	1.11M	19.03M	0	0
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	1.58%	1.19M	20.34M	-1.59K	-0.13%
Sep 30, 2025	ASSENAGON ASSET MANAGEMENT S.A.	1.76%	1.33M	22.66M	833.99K	+169.24%
Sep 30, 2025	DEUTSCHE BANK AG\	2.05%	1.54M	26.39M	135	+0.01%
Sep 30, 2025	BLACKSTONE INC.	2.15%	1.62M	27.61M	-40.5K	-2.44%
Sep 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	2.27%	1.71M	29.21M	-749.05K	-30.46%
Sep 30, 2025	VESTAL POINT CAPITAL, LP	2.34%	1.77M	30.15M	615K	+53.48%
Sep 30, 2025	PERCEPTIVE ADVISORS LLC	2.78%	2.09M	35.71M	815.39K	+63.94%
Sep 30, 2025	VANGUARD GROUP INC	2.86%	2.15M	36.8M	-310.26K	-12.59%
Sep 30, 2025	REDMILE GROUP, LLC	4.92%	3.71M	63.29M	-444.88K	-10.72%
Sep 30, 2025	BVF INC/IL	5.23%	3.94M	67.27M	-370.29K	-8.59%
Sep 30, 2025	MORGAN STANLEY	5.29%	3.98M	68.06M	-193.03K	-4.62%
Sep 30, 2025	BLACKROCK, INC.	5.3%	3.99M	68.14M	195.26K	+5.15%
Sep 30, 2025	RUBRIC CAPITAL MANAGEMENT LP	6.25%	4.71M	80.46M	0	0
Sep 30, 2025	ECOR1 CAPITAL, LLC	30.49%	22.97M	392.33M	0	0
Sep 30, 2025	FEDERATED HERMES, INC.	0.24%	182.85K	3.12M	577	+0.32%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.23%	176.63K	3.02M	10.21K	+6.13%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.22%	168.69K	2.88M	-12.01K	-6.64%
Sep 30, 2025	AXA INVESTMENT MANAGERS S.A.	0.21%	158.42K	2.71M	158.42K	+100.00%
Sep 30, 2025	MARSHALL WACE, LLP	0.21%	154.86K	2.64M	154.86K	+100.00%
Sep 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.2%	152.63K	2.61M	-13.51K	-8.13%
Sep 30, 2025	DIADEMA PARTNERS LP	0.26%	196.5K	3.36M	17.2K	+9.59%
Sep 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.21%	161.49K	2.78M	-143.18K	-47.00%
Sep 30, 2025	MAN GROUP PLC	0.21%	158.62K	2.71M	123.21K	+347.99%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.2%	154.2K	2.63M	86.1K	+126.43%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.18%	137.55K	2.35M	4.46K	+3.35%
Sep 30, 2025	PLATINUM INVESTMENT MANAGEMENT LTD	0.17%	124.78K	2.13M	-113.61K	-47.66%
Sep 30, 2025	RAYMOND JAMES FINANCIAL INC	0.16%	122.87K	2.1M	-1.57K	-1.26%
Sep 30, 2025	CITIGROUP INC	0.16%	117.8K	2.01M	-38.19K	-24.48%
Sep 30, 2025	HILLSDALE INVESTMENT MANAGEMENT INC.	0.29%	216.42K	3.7M	11.4K	+5.56%
Sep 30, 2025	ALGERT GLOBAL LLC	0.28%	207.93K	3.55M	89.82K	+76.05%
Sep 30, 2025	SAMSARA BIOCAPITAL, LLC	0.28%	207.9K	3.55M	-102.4K	-33.00%
Sep 30, 2025	JANE STREET GROUP, LLC	0.19%	145.21K	2.48M	132.66K	+1,057.11%
Sep 30, 2025	GRANAHAN INVESTMENT MANAGEMENT, LLC	0.46%	345.33K	5.9M	-35.45K	-9.31%
Sep 30, 2025	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	0.42%	313.75K	5.36M	313.75K	+100.00%
Sep 30, 2025	BARCLAYS PLC	0.26%	199.02K	3.4M	76.2K	+62.04%
Sep 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.19%	146.44K	2.5M	-514	-0.35%
Sep 30, 2025	SILVERCREST ASSET MANAGEMENT GROUP LLC	0.36%	272.8K	4.66M	-7.93K	-2.82%
Sep 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.34%	255K	4.36M	185.13K	+264.95%
Sep 30, 2025	NORTHERN TRUST CORP	0.46%	348.25K	5.95M	-1.55K	-0.44%
Sep 30, 2025	JUPITER ASSET MANAGEMENT LTD	0.47%	350.66K	5.99M	-18.84K	-5.10%
Sep 30, 2025	SQUAREPOINT OPS LLC	0.29%	219.95K	3.76M	64.35K	+41.36%
Sep 30, 2025	CITADEL ADVISORS LLC	0.27%	206.86K	3.53M	-39.3K	-15.96%
Sep 30, 2025	PANAGORA ASSET MANAGEMENT INC	0.14%	106.07K	1.81M	72.51K	+216.08%
Sep 30, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.13%	96.8K	1.65B	96.8K	+100.00%
Sep 30, 2025	INVESCO LTD.	0.12%	93.66K	1.6M	4.29K	+4.80%
Sep 30, 2025	RHUMBLINE ADVISERS	0.11%	85.9K	1.47M	-181	-0.21%
Sep 30, 2025	TEJARA CAPITAL LTD	0.11%	85.16K	1.45M	-114.99K	-57.45%
Sep 30, 2025	NORTH GROWTH MANAGEMENT LTD.	0.11%	82K	1.41M	-15K	-15.46%
Sep 30, 2025	SWISS NATIONAL BANK	0.1%	73.1K	1.25M	0	0
Sep 30, 2025	STIFEL FINANCIAL CORP	0.1%	72.53K	1.24M	2.8K	+4.02%
Sep 30, 2025	FISHER ASSET MANAGEMENT, LLC	0.1%	71.97K	1.23M	-5	-0.01%
Sep 30, 2025	NEOS INVESTMENT MANAGEMENT LLC	0.08%	63.66K	1.09M	11.81K	+22.77%
Sep 30, 2025	TEMA ETFS LLC	0.08%	63.66K	1.09M	11.81K	+22.77%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.08%	57.45K	981.21K	29.14K	+102.91%
Sep 30, 2025	MACKENZIE FINANCIAL CORP	0.07%	56.38K	962.92K	35.02K	+164.00%
Sep 30, 2025	VIRGINIA RETIREMENT SYSTEMS ET AL	0.07%	55.98K	956.05K	1.9K	+3.51%
Sep 30, 2025	DLD ASSET MANAGEMENT, LP	0.07%	52.9K	904.06K	52.9K	+100.00%
Sep 30, 2025	UBS GROUP AG	0.07%	51.84K	885.44K	-199.67K	-79.39%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.07%	51.02K	871.35K	19.87K	+63.79%
Sep 30, 2025	O'SHAUGHNESSY ASSET MANAGEMENT, LLC	0.06%	41.77K	713.4K	544	+1.32%
Sep 30, 2025	STRS OHIO	0.05%	40.9K	698.57K	-5.4K	-11.66%
Sep 30, 2025	HSBC HOLDINGS PLC	0.05%	37.6K	639.58K	1.1K	+3.02%
Sep 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.05%	34.51K	589.43K	-100	-0.29%
Jun 30, 2025	AXA S.A.	0.23%	175.12K	2.2M	175.12K	+100.00%
Jun 30, 2025	HILLSDALE INVESTMENT MANAGEMENT INC.	0.27%	205.02K	2.57M	-31.9K	-13.47%
Jun 30, 2025	NORGES BANK	0.27%	201.7K	2.53M	201.7K	+100.00%
Jun 30, 2025	TEJARA CAPITAL LTD	0.27%	200.15K	2.51M	10.74K	+5.67%
Jun 30, 2025	FEDERATED HERMES, INC.	0.24%	182.27K	2.29M	358	+0.20%
Jun 30, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.66%	492.78K	6.18M	-2.29K	-0.46%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.57%	428.86K	5.38B	228.81K	+114.38%
Jun 30, 2025	D. E. SHAW & CO., INC.	0.34%	255.29K	3.2B	192.19K	+304.59%
Jun 30, 2025	CITADEL ADVISORS LLC	0.33%	246.16K	3.09B	65.49K	+36.25%
Jun 30, 2025	VANGUARD GROUP INC	3.28%	2.46M	30.93M	697.65K	+39.48%
Jun 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	3.27%	2.46M	30.87M	-1.42M	-36.61%
Jun 30, 2025	DEUTSCHE BANK AG\	2.06%	1.54M	19.39M	-7.85K	-0.51%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	1.59%	1.19M	14.96M	112.97K	+10.47%
Jun 30, 2025	STATE STREET CORP	1.45%	1.09M	13.66M	3.33K	+0.31%
Jun 30, 2025		0.24%	179.3K	2.25M	0	0
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	0.04%	31.15K	390.9K	0	0
Jun 30, 2025	WELLS FARGO & COMPANY/MN	0.22%	166.43K	2.09M	66.12K	+65.92%
Jun 30, 2025	CITIGROUP INC	0.21%	156K	1.96M	114.8K	+278.65%
Jun 30, 2025	SQUAREPOINT OPS LLC	0.21%	155.6K	1.95M	92K	+144.64%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.18%	133.09K	1.67M	12.36K	+10.24%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.17%	124.2K	1.56M	-9.44K	-7.06%
Jun 30, 2025	BARCLAYS PLC	0.16%	122.82K	1.54M	47.39K	+62.83%
Jun 30, 2025	DARK FOREST CAPITAL MANAGEMENT LP	0.13%	96.99K	1.22M	-8.84K	-8.35%
Jun 30, 2025	NORTH GROWTH MANAGEMENT LTD.	0.13%	97K	1.22M	0	0
Jun 30, 2025	ALGERT GLOBAL LLC	0.16%	118.1K	1.48M	118.1K	+100.00%
Jun 30, 2025	RAYMOND JAMES FINANCIAL INC	0.17%	124.44K	1.56M	7.72K	+6.62%
Jun 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.22%	166.14K	2.09B	117.66K	+242.67%
Jun 30, 2025	OPALEYE MANAGEMENT INC.	0.28%	210K	2.64M	35K	+20.00%
Jun 30, 2025	PLATINUM INVESTMENT MANAGEMENT LTD	0.32%	238.39K	2.99M	-40.27K	-14.45%
Jun 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.41%	304.67K	3.8M	-17.28K	-5.37%
Jun 30, 2025	JPMORGAN CHASE & CO	0.59%	441.69K	5.54M	403.28K	+1,049.96%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.94%	705.36K	8.85M	329	+0.05%
Jun 30, 2025	NEXTECH INVEST, LTD.	1.48%	1.11M	13.98B	0	0
Jun 30, 2025	DIADEMA PARTNERS LP	0.24%	179.3K	2.25M	0	0
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.71%	533.3K	6.69M	82.7K	+18.35%
Jun 30, 2025	NUVEEN, LLC	0.87%	654.92K	8.22M	456.1K	+229.41%
Jun 30, 2025	TUDOR INVESTMENT CORP ET AL	0.05%	34.29K	430.38K	34.29K	+100.00%
Jun 30, 2025	MAN GROUP PLC	0.05%	35.41K	444.35K	24.55K	+226.05%
Jun 30, 2025	O'SHAUGHNESSY ASSET MANAGEMENT, LLC	0.05%	41.22K	517.36K	-55.11K	-57.21%
Jun 30, 2025	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0.06%	42.87K	538.06M	-910	-2.08%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.07%	50.03K	627.88M	0	0
Jun 30, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.07%	51.67K	648K	-81.65K	-61.24%
Jun 30, 2025	NEOS INVESTMENT MANAGEMENT LLC	0.07%	51.86K	650.78K	18.85K	+57.13%
Jun 30, 2025	VIRGINIA RETIREMENT SYSTEMS ET AL	0.07%	54.08K	678.64K	9.9K	+22.41%
Jun 30, 2025	WEISS ASSET MANAGEMENT LP	0.07%	54.17K	679.85K	54.17K	+100.00%
Jun 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.09%	69.87K	876.92K	69.87K	+100.00%
Jun 30, 2025	FISHER ASSET MANAGEMENT, LLC	0.1%	71.98K	903.34K	5	+0.01%
Jun 30, 2025	ROYAL BANK OF CANADA	0.1%	72.98K	915K	16.21K	+28.56%
Jun 30, 2025	ACUTA CAPITAL PARTNERS, LLC	0.11%	83.66K	1.05M	15.2K	+22.20%
Jun 30, 2025	SUSQUEHANNA PORTFOLIO STRATEGIES, LLC	0.11%	85.73K	1.08M	85.73K	+100.00%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.24%	180.69K	2.27M	-1.56K	-0.85%
Jun 30, 2025	BVF INC/IL	5.73%	4.31M	54.08M	0	0
Jun 30, 2025	REDMILE GROUP, LLC	5.52%	4.15M	52.09M	-638.32K	-13.33%
Jun 30, 2025	BLACKROCK, INC.	5.05%	3.79M	47.62M	-295.15K	-7.22%
Jun 30, 2025	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	2.71%	2.04M	25.6M	-158.22K	-7.20%
Jun 30, 2025	BLACKSTONE INC.	2.2%	1.66M	20.79M	274.2K	+19.83%
Jun 30, 2025	PROSIGHT MANAGEMENT, LP	1.74%	1.31M	16.44M	352.68K	+36.84%
Jun 30, 2025	PERCEPTIVE ADVISORS LLC	1.7%	1.28M	16M	-589.4K	-31.61%
Jun 30, 2025	VESTAL POINT CAPITAL, LP	1.53%	1.15M	14.43M	650K	+130.00%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.63%	476K	5.97M	476K	+100.00%
Jun 30, 2025	GRANAHAN INVESTMENT MANAGEMENT, LLC	0.51%	380.78K	4.78M	-26.81K	-6.58%
Jun 30, 2025	JUPITER ASSET MANAGEMENT LTD	0.49%	369.5K	4.64M	0	0
Jun 30, 2025	NORTHERN TRUST CORP	0.47%	349.8K	4.39M	-37.12K	-9.59%
Jun 30, 2025	SAMSARA BIOCAPITAL, LLC	0.41%	310.3K	3.89M	-356.37K	-53.46%
Jun 30, 2025	SILVERCREST ASSET MANAGEMENT GROUP LLC	0.37%	280.73K	3.52M	0	0
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.34%	259.14K	3.25M	-92.02K	-26.21%
Jun 30, 2025	UBS GROUP AG	0.33%	251.51K	3.16M	37.21K	+17.36%
Jun 30, 2025	TREXQUANT INVESTMENT LP	0.29%	220.98K	2.77M	173	+0.08%
Jun 30, 2025	PICTON MAHONEY ASSET MANAGEMENT	0.28%	207.6K	2.61M	-427	-0.21%
Jun 30, 2025	TANG CAPITAL MANAGEMENT LLC	1.46%	1.1M	13.81M	0	0
Jun 30, 2025	ECOR1 CAPITAL, LLC	30.56%	22.97M	288.28M	5.71M	+33.09%
Jun 30, 2025	RUBRIC CAPITAL MANAGEMENT LP	6.27%	4.71M	59.12M	372.11K	+8.58%
Jun 30, 2025	MORGAN STANLEY	5.56%	4.18M	52.43B	104.15K	+2.56%
Jun 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.2%	146.95K	1.84M	10.64K	+7.80%
Jun 30, 2025	HRT FINANCIAL LP	0.04%	32.76K	411K	-32.62K	-49.90%
Jun 30, 2025	COMMONWEALTH EQUITY SERVICES, LLC	0.04%	32.17K	404K	-5.47K	-14.54%
Mar 31, 2025	BLACKROCK, INC.	5.44%	4.09M	48.71M	-95.54K	-2.28%
Mar 31, 2025	ECOR1 CAPITAL, LLC	22.96%	17.26M	205.56M	2.23M	+14.85%
Mar 31, 2025	REDMILE GROUP, LLC	6.37%	4.79M	57.04M	-51.52K	-1.06%
Mar 31, 2025	RUBRIC CAPITAL MANAGEMENT LP	5.77%	4.34M	51.67M	421.11K	+10.75%
Mar 31, 2025	SAMSARA BIOCAPITAL, LLC	0.89%	666.67K	7.94M	-333.33K	-33.33%
Mar 31, 2025	BVF INC/IL	5.73%	4.31M	51.32M	0	0
Mar 31, 2025	MORGAN STANLEY	5.42%	4.07M	48.51M	-127.97K	-3.05%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.94%	705.04K	8.4M	15.15K	+2.20%
Mar 31, 2025	VESTAL POINT CAPITAL, LP	0.67%	500K	5.96M	315K	+170.27%
Mar 31, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.66%	495.07K	5.9M	-147.18K	-22.92%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.6%	450.6K	5.37M	164.9K	+57.72%
Mar 31, 2025	GRANAHAN INVESTMENT MANAGEMENT, LLC	0.54%	407.59K	4.85M	-3.53K	-0.86%
Mar 31, 2025	OPALEYE MANAGEMENT INC.	0.23%	175K	2.08M	175K	+100.00%
Mar 31, 2025	TREXQUANT INVESTMENT LP	0.29%	220.81K	2.63M	118.81K	+116.49%
Mar 31, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.18%	136.32K	1.62M	-3.63K	-2.60%
Mar 31, 2025	JANE STREET GROUP, LLC	0.18%	135.76K	1.62M	112.64K	+487.03%
Mar 31, 2025	PICTON MAHONEY ASSET MANAGEMENT	0.28%	208.03K	2.48M	1.46K	+0.71%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.27%	200.05K	2.38M	-49.91K	-19.97%
Mar 31, 2025	TEJARA CAPITAL LTD	0.25%	189.41K	2.26M	150.87K	+391.50%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.24%	182.25K	2.17M	-36.85K	-16.82%
Mar 31, 2025	JUPITER ASSET MANAGEMENT LTD	0.49%	369.5K	4.4M	0	0
Mar 31, 2025	EMPOWERED FUNDS, LLC	0.48%	360.04K	4.29M	7.29K	+2.07%
Mar 31, 2025	FEDERATED HERMES, INC.	0.24%	181.91K	2.17M	286	+0.16%
Mar 31, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.18%	133.32K	1.59M	133.32K	+100.00%
Mar 31, 2025	TANG CAPITAL MANAGEMENT LLC	1.46%	1.1M	13.1M	0	0
Mar 31, 2025	PROSIGHT MANAGEMENT, LP	1.27%	957.23K	11.4M	137.23K	+16.74%
Mar 31, 2025	FARALLON CAPITAL MANAGEMENT LLC	0.53%	400K	4.76M	-929.97K	-69.92%
Mar 31, 2025	NORTHERN TRUST CORP	0.51%	386.92K	4.61M	-7.91K	-2.00%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.47%	351.16K	4.18M	299.65K	+581.65%
Mar 31, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.43%	321.95K	3.98M	-15.21K	-4.51%
Mar 31, 2025	PLATINUM INVESTMENT MANAGEMENT LTD	0.37%	278.66K	3.32M	-27.8K	-9.07%
Mar 31, 2025	WALLEYE CAPITAL LLC	0.33%	247.96K	2.95M	-204.85K	-45.24%
Mar 31, 2025	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	2.92%	2.2M	26.18M	60.23K	+2.82%
Mar 31, 2025	PERCEPTIVE ADVISORS LLC	2.48%	1.86M	22.21M	-265.35K	-12.46%
Mar 31, 2025	VANGUARD GROUP INC	2.35%	1.77M	21.05M	-726.25K	-29.13%
Mar 31, 2025	STATE STREET CORP	1.44%	1.09M	12.92M	172	+0.02%
Mar 31, 2025	CITADEL ADVISORS LLC	0.24%	180.67K	2.15M	122.31K	+209.59%
Mar 31, 2025		0.24%	179.3K	2.14M	179.3K	+100.00%
Mar 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	5.16%	3.88M	46.21M	2.51M	+184.22%
Mar 31, 2025	DEUTSCHE BANK AG\	2.07%	1.55M	18.49M	5.84K	+0.38%
Mar 31, 2025	BLACKSTONE INC.	1.84%	1.38M	16.47M	812.87K	+142.68%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	1.44%	1.08M	12.86M	106.72K	+10.97%
Mar 31, 2025	BRIDGEWAY CAPITAL MANAGEMENT, LLC	1.02%	766.94K	9.13M	7.29K	+0.96%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.39%	295.61K	3.52M	295.61K	+100.00%
Mar 31, 2025	SILVERCREST ASSET MANAGEMENT GROUP LLC	0.37%	280.73K	3.34M	-1.62K	-0.57%
Mar 31, 2025	HILLSDALE INVESTMENT MANAGEMENT INC.	0.32%	236.93K	2.82M	6.9K	+3.00%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.18%	133.64K	1.59M	2.33K	+1.78%
Mar 31, 2025	UBS GROUP AG	0.29%	214.3K	2.55M	47.4K	+28.40%
Dec 31, 2022	VANGUARD GROUP INC	0%	0	-	-523.98K	-100.00%
Dec 31, 2022	STATE STREET CORP	0%	0	-	-99.36K	-100.00%
Dec 31, 2022	GRAHAM CAPITAL MANAGEMENT, L.P.	0%	0	-	-158.07K	-100.00%
Dec 31, 2022	GUGGENHEIM CAPITAL LLC	0%	0	-	-18.83K	-100.00%
Dec 31, 2022	IFP ADVISORS, INC	0%	300	7K	0	0
Dec 31, 2022	MILLENNIUM MANAGEMENT LLC	0%	0	-	-192.63K	-100.00%
Dec 31, 2022	MARATHON CAPITAL MANAGEMENT	0%	0	-	-27.25K	-100.00%
Dec 31, 2022	NORTHERN TRUST CORP	0%	0	-	-14.24K	-100.00%
Dec 31, 2022	WELLS FARGO & COMPANY/MN	0%	0	-	-108.93K	-100.00%
Dec 31, 2022	NATIONAL BANK OF CANADA /FI/	0%	0	-	-395.48K	-100.00%
Dec 31, 2022	CITIGROUP INC	0%	0	-	-48	-100.00%
Dec 31, 2022	CREDIT SUISSE AG/	0%	0	-	-2.44M	-100.00%
Dec 31, 2022	PNC FINANCIAL SERVICES GROUP, INC.	0%	0	-	-178	-100.00%
Dec 31, 2022	J. GOLDMAN & CO LP	0%	0	-	-291K	-100.00%
Dec 31, 2022	ARTAL GROUP S.A.	0.68%	450K	3.54M	0	0
Dec 31, 2022	MORGAN STANLEY	0%	0	-	-5.26M	-100.00%
Dec 31, 2022	INVESCO LTD.	0%	0	-	-51.44K	-100.00%
Dec 31, 2022	BANK OF MONTREAL /CAN/	0%	0	-	-47.12K	-100.00%
Dec 31, 2022	GROUP ONE TRADING, L.P.	0%	0	-	-42.55K	-100.00%
Dec 31, 2022	DEUTSCHE BANK AG\	0%	0	-	-91.66K	-100.00%
Dec 31, 2022	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0%	0	-	-181.75K	-100.00%
Dec 31, 2022	CAMBER CAPITAL MANAGEMENT LP	0%	0	-	-2.87M	-100.00%
Dec 31, 2022	ALYESKA INVESTMENT GROUP, L.P.	0%	0	-	-1.5M	-100.00%
Dec 31, 2022	RAYMOND JAMES FINANCIAL SERVICES ADVISORS, INC.	0%	0	-	-72.52K	-100.00%
Dec 31, 2022	SIMPLEX TRADING, LLC	0%	0	-	-35.07K	-100.00%
Dec 31, 2022	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	0%	0	-	-1.51M	-100.00%
Dec 31, 2022	EVENTIDE ASSET MANAGEMENT, LLC	0%	0	-	-5.38M	-100.00%
Dec 31, 2022	JPMORGAN CHASE & CO	0%	0	-	-11	-100.00%
Dec 31, 2022	ROYAL BANK OF CANADA	0%	0	-	-33.88K	-100.00%
Dec 31, 2022	BROOKFIELD CORP /ON/	0%	0	-	-203.65K	-100.00%
Dec 31, 2022	D. E. SHAW & CO., INC.	0%	0	-	-88.48K	-100.00%
Dec 31, 2022	GRANAHAN INVESTMENT MANAGEMENT, LLC	0%	0	-	-587.81K	-100.00%
Dec 31, 2022	RENAISSANCE TECHNOLOGIES LLC	0%	0	-	-57.78K	-100.00%
Dec 31, 2022	RAYMOND JAMES & ASSOCIATES	0%	0	-	-165.93K	-100.00%
Dec 31, 2022	PARALLAX VOLATILITY ADVISERS, L.P.	0%	0	-	-30K	-100.00%
Dec 31, 2022	UBS OCONNOR LLC	0%	0	-	-215K	-100.00%
Dec 31, 2022	CI INVESTMENTS INC.	0%	0	-	-146.47K	-100.00%
Dec 31, 2022	LAZARD ASSET MANAGEMENT LLC	0%	0	-	-17.63K	-100.00%
Dec 31, 2022	PERCEPTIVE ADVISORS LLC	0%	0	-	-4.4M	-100.00%
Dec 31, 2022	PLATINUM INVESTMENT MANAGEMENT LTD	0%	0	-	-373.99K	-100.00%
Dec 31, 2022	BANK OF AMERICA CORP /DE/	0%	0	-	-2.79K	-100.00%
Dec 31, 2022	BLACKROCK INC.	0%	0	-	-581.71K	-100.00%
Dec 31, 2022	WALLEYE TRADING LLC	0%	0	-	-15.51K	-100.00%
Dec 31, 2022	CITADEL ADVISORS LLC	0%	0	-	-123.33K	-100.00%
Dec 31, 2022	REDMILE GROUP, LLC	0%	0	-	-5.77M	-100.00%
Dec 31, 2022	SAMSARA BIOCAPITAL, LLC	2.44%	1.62M	12.74M	649.7K	+66.91%
Dec 31, 2022	BAKER BROS. ADVISORS LP	0%	0	-	-1.71M	-100.00%
Dec 31, 2022	JANNEY MONTGOMERY SCOTT LLC	0%	0	-	-52.38K	-100.00%
Dec 31, 2022	PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO	0%	0	-	-7.99K	-100.00%
Dec 31, 2022	THRIVENT FINANCIAL FOR LUTHERANS	0%	0	-	-16.08K	-100.00%
Dec 31, 2022	BARCLAYS PLC	0%	0	-	-1.12K	-100.00%

Insiders

Among the ZYME insiders holding of 0.19% of the stake in company, ECOR1 CAPITAL, LLC, , holds the largest shares of 17.88M. REDMILE GROUP, LLC, 10 percent owner, is the second largest ZYME insider with ownership of 6.08M shares. LILLY ELI & CO, 10 percent owner, stands third with possession of 2.9M shares of that stake.

Insiders	Designation	Shares Held
ECOR1 CAPITAL, LLC		17.88M
REDMILE GROUP, LLC	10 percent owner	6.08M
LILLY ELI & CO	10 percent owner	2.9M
TEHRANI ALI	Chief Executive Officer	260.33K
GALBRAITH KENNETH	Chair & CEO	226.84K
HOLLYWOOD MARK	EVP & Chief Operating Officer	132.91K
MOORE PAUL ANDREW	Chief Scientific Officer	48.5K
POLVERINO ANTHONY J.	Chief Scientific Officer	30.98K
SMITH JEFFREY T L	EVP & Chief Medical Officer	26.71K
KLOMPAS NEIL A	President & COO	17.03K
JOSEPHSON NEIL	Chief Medical Officer	14.45K
COX TROY	director	7.5K
ASTLE CHRISTOPHER	SVP & Chief Financial Officer	6.5K
HAUSMAN DIANA	Chief Medical Officer	5.38K
O'DRISCOLL KATHRYN	Chief People Officer	5K
PRIOUR JAMES	Chief Commercial Officer	2K
POON DAVID KAI YUEN	See Remarks	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Jan 12, 2026	MOORE PAUL ANDREW	SALE	22.67	9.56K	216.76K	48.5K
Jan 12, 2026	HOLLYWOOD MARK	SALE	22.67	6.12K	138.76K	132.91K
Jan 12, 2026	GALBRAITH KENNETH	SALE	22.67	30.42K	689.82K	226.84K
Jan 12, 2026	SMITH JEFFREY T L	SALE	22.67	9.31K	211.09K	26.71K
Jan 05, 2026	GALBRAITH KENNETH	SALE	25.10	22.66K	568.62K	158.29K
Jan 05, 2026	SMITH JEFFREY T L	SALE	25.10	10.54K	264.47K	18.35K
Jan 05, 2026	MOORE PAUL ANDREW	SALE	25.10	9.29K	233.13K	31.21K
Dec 22, 2025	GALBRAITH KENNETH	SALE	27.02	47.53K	1.28M	133.28K
May 19, 2025	ECOR1 CAPITAL, LLC	PURCHASE	11.78	5.92K	69.74K	17.88M
May 15, 2025	ECOR1 CAPITAL, LLC	PURCHASE	11.43	49.5K	565.85K	17.88M
Apr 17, 2025	ECOR1 CAPITAL, LLC	PURCHASE	11.52	54.76K	630.82K	17.83M
Apr 16, 2025	ECOR1 CAPITAL, LLC	PURCHASE	11.16	73.95K	825.59K	17.77M
Apr 04, 2025	ECOR1 CAPITAL, LLC	PURCHASE	11.17	196.44K	2.19M	17.7M
Apr 03, 2025	ECOR1 CAPITAL, LLC	PURCHASE	11.84	120.77K	1.43M	17.5M
Apr 02, 2025	ECOR1 CAPITAL, LLC	PURCHASE	11.85	74.36K	881.02K	17.38M
Apr 01, 2025	ECOR1 CAPITAL, LLC	PURCHASE	11.60	48.66K	564.65K	17.31M
Mar 31, 2025	ECOR1 CAPITAL, LLC	PURCHASE	11.75	4.4K	51.66K	17.26M
Mar 26, 2025	ECOR1 CAPITAL, LLC	PURCHASE	12.24	43.85K	536.86K	17.26M
Mar 25, 2025	ECOR1 CAPITAL, LLC	PURCHASE	12.91	53.5K	690.45K	17.21M
Mar 24, 2025	ECOR1 CAPITAL, LLC	PURCHASE	13.08	22.69K	296.85K	17.16M
Mar 21, 2025	ECOR1 CAPITAL, LLC	PURCHASE	12.78	31.03K	396.52K	17.14M
Mar 20, 2025	ECOR1 CAPITAL, LLC	PURCHASE	12.93	73.48K	949.88K	17.1M
Mar 19, 2025	ECOR1 CAPITAL, LLC	PURCHASE	12.64	58.31K	737.23K	17.03M
Mar 18, 2025	ECOR1 CAPITAL, LLC	PURCHASE	12.65	113.88K	1.44M	16.97M
Mar 17, 2025	ECOR1 CAPITAL, LLC	PURCHASE	12.23	56.28K	688.46K	16.86M
Mar 13, 2025	ECOR1 CAPITAL, LLC	PURCHASE	12.48	468.36K	5.85M	16.8M
Mar 12, 2025	ECOR1 CAPITAL, LLC	PURCHASE	12.25	292.93K	3.59M	16.33M
Mar 11, 2025	ECOR1 CAPITAL, LLC	PURCHASE	11.49	320.69K	3.69M	16.04M
Jan 17, 2025	ECOR1 CAPITAL, LLC	PURCHASE	13.87	19.75K	274K	15.72M
Jan 16, 2025	ECOR1 CAPITAL, LLC	PURCHASE	13.88	121.68K	1.69M	15.7M
Jan 15, 2025	ECOR1 CAPITAL, LLC	PURCHASE	14.01	39.03K	546.67K	15.58M
Jan 14, 2025	ECOR1 CAPITAL, LLC	PURCHASE	13.56	54.5K	739.27K	15.54M
Jan 13, 2025	ECOR1 CAPITAL, LLC	PURCHASE	13.39	74.13K	992.87K	15.49M
Jan 10, 2025	ECOR1 CAPITAL, LLC	PURCHASE	13.13	204.1K	2.68M	15.41M
Jan 08, 2025	ECOR1 CAPITAL, LLC	PURCHASE	14.07	21.02K	295.83K	15.21M
Jan 06, 2025	SMITH JEFFREY T L	SALE	14.92	11.11K	165.81K	8.89K
Jan 06, 2025	MOORE PAUL ANDREW	SALE	14.92	9.79K	146.14K	14.74K
Jan 06, 2025	GALBRAITH KENNETH	SALE	14.92	23.89K	356.46K	47.54K
Jan 02, 2025	ECOR1 CAPITAL, LLC	PURCHASE	14.78	157.88K	2.33M	15.19M
Dec 31, 2024	ECOR1 CAPITAL, LLC	PURCHASE	14.57	146.5K	2.13M	15.03M
Dec 30, 2024	ECOR1 CAPITAL, LLC	PURCHASE	14.47	58.99K	853.33K	14.88M
Dec 27, 2024	ECOR1 CAPITAL, LLC	PURCHASE	14.49	101.66K	1.47M	14.82M
Dec 26, 2024	ECOR1 CAPITAL, LLC	PURCHASE	14.38	16.69K	240.04K	14.72M
Dec 24, 2024	ECOR1 CAPITAL, LLC	PURCHASE	14.12	11.96K	168.9K	14.7M
Dec 23, 2024	ECOR1 CAPITAL, LLC	PURCHASE	14.25	251.5K	3.58M	14.69M
Dec 20, 2024	ECOR1 CAPITAL, LLC	PURCHASE	14.08	704.49K	9.92M	14.44M
Dec 19, 2024	ECOR1 CAPITAL, LLC	PURCHASE	13.53	298.82K	4.04M	13.74M
Jan 08, 2024	MOORE PAUL ANDREW	SALE	11.22	2.34K	26.23K	7.37K
Jan 08, 2024	GALBRAITH KENNETH	SALE	11.22	5.71K	64K	23.76K
Jan 08, 2024	ASTLE CHRISTOPHER	SALE	11.22	1.43K	16.05K	6.5K
Jan 05, 2024	GALBRAITH KENNETH	SALE	10.65	18.2K	193.85K	29.47K
Jan 05, 2024	ASTLE CHRISTOPHER	SALE	10.65	4.56K	48.61K	7.93K
Jan 05, 2024	MOORE PAUL ANDREW	SALE	10.65	7.46K	79.47K	9.71K
Dec 26, 2023	ECOR1 CAPITAL, LLC	PURCHASE	0.00	5.09M	508.65	5.09M
Dec 11, 2023	ASTLE CHRISTOPHER	SALE	9.13	886	8.09K	2K
Jun 16, 2023	ECOR1 CAPITAL, LLC	PURCHASE	8.12	3.35M	27.2M	13.44M
Mar 28, 2023	ECOR1 CAPITAL, LLC	PURCHASE	8.00	200K	1.6M	10.09M
Mar 10, 2023	KLOMPAS NEIL A	SALE	7.83	2.98K	23.3K	17.03K
Jan 20, 2023	ECOR1 CAPITAL, LLC	PURCHASE	9.88	163.4K	1.62M	9.89M
Jan 19, 2023	ECOR1 CAPITAL, LLC	PURCHASE	9.49	144.1K	1.37M	9.72M
Jan 18, 2023	ECOR1 CAPITAL, LLC	PURCHASE	10.00	203K	2.03M	9.58M
Jan 17, 2023	ECOR1 CAPITAL, LLC	PURCHASE	9.80	440K	4.31M	9.38M
Jan 13, 2023	ECOR1 CAPITAL, LLC	PURCHASE	9.81	342.1K	3.35M	8.94M
Jan 11, 2023	ECOR1 CAPITAL, LLC	PURCHASE	7.87	106.3K	836.91K	8.59M
Jan 10, 2023	ECOR1 CAPITAL, LLC	PURCHASE	7.65	920K	7.04M	8.49M
Nov 10, 2022	JOSEPHSON NEIL	SALE	8.10	2.48K	20.05K	14.45K
Oct 13, 2022	REDMILE GROUP, LLC	PURCHASE	5.03	30.48K	153.44K	6.08M
Mar 10, 2022	KLOMPAS NEIL A	SALE	6.88	2.98K	20.5K	13.28K
Jan 07, 2022	JOSEPHSON NEIL	PURCHASE	14.27	1.4K	19.98K	3.52K
Jul 16, 2021	TEHRANI ALI	SALE	36.00	41.19K	1.48M	260.33K
Jul 12, 2021	TEHRANI ALI	SALE	36.12	12.67K	457.63K	260.33K
Apr 13, 2021	PRIOUR JAMES	SALE	27.93	950	26.53K	2K
Mar 15, 2021	O'DRISCOLL KATHRYN	SALE	34.72	786	27.29K	5K
Mar 10, 2021	TEHRANI ALI	SALE	34.95	4.39K	153.52K	260.33K
Mar 10, 2021	KLOMPAS NEIL A	SALE	34.95	1.43K	49.81K	10.47K
Mar 10, 2021	O'DRISCOLL KATHRYN	SALE	34.95	568	19.85K	5.79K
Mar 10, 2021	POLVERINO ANTHONY J.	SALE	34.95	1.05K	36.63K	30.98K
Mar 10, 2021	HAUSMAN DIANA	SALE	34.95	1.05K	36.63K	5.38K
Dec 09, 2020	KLOMPAS NEIL A	SALE	53.25	25K	1.33M	9.12K
Dec 07, 2020	TEHRANI ALI	SALE	56.16	850	47.74K	55.51K
Dec 04, 2020	HAUSMAN DIANA	SALE	55.12	6.03K	332.48K	3.72K
Dec 02, 2020	HAUSMAN DIANA	SALE	55.01	701	38.56K	3.72K
Dec 01, 2020	HAUSMAN DIANA	SALE	55.19	18.27K	1.01M	3.72K
Nov 02, 2020	TEHRANI ALI	SALE	39.04	3.5K	136.62K	56.36K
Sep 14, 2020	HAUSMAN DIANA	SALE	45.00	40K	1.8M	3.72K
Apr 03, 2020	TEHRANI ALI	PURCHASE	33.39	495	16.53K	59.78K
Jan 27, 2020	COX TROY	PURCHASE	46.50	7.5K	348.75K	7.5K
May 06, 2019	KLOMPAS NEIL A	SALE	19.22	6.7K	128.85K	1.2K
May 06, 2019	POON DAVID KAI YUEN	SALE	19.20	800	15.36K	0
Mar 29, 2019	TEHRANI ALI	SALE	16.24	3K	48.72K	59.29K
Jan 31, 2019	LILLY ELI & CO	SALE	16.00	250K	4M	2.9M
Nov 06, 2018	LILLY ELI & CO	SALE	14.00	700K	9.8M	3.15M
Sep 24, 2018	LILLY ELI & CO	SALE	16.36	2.03K	33.16K	3.85M
Sep 18, 2018	LILLY ELI & CO	SALE	14.56	6.87K	100.03K	3.85M
Sep 17, 2018	LILLY ELI & CO	SALE	14.58	6.87K	100.09K	3.86M
Sep 14, 2018	LILLY ELI & CO	SALE	14.58	9.01K	131.35K	3.86M
Sep 13, 2018	LILLY ELI & CO	SALE	14.32	20.9K	299.29K	3.87M
Sep 12, 2018	LILLY ELI & CO	SALE	14.83	10.06K	149.17K	3.89M
Sep 11, 2018	LILLY ELI & CO	SALE	14.87	11.28K	167.69K	3.9M
Sep 10, 2018	LILLY ELI & CO	SALE	14.44	4.5K	64.98K	3.92M
Aug 31, 2018	LILLY ELI & CO	SALE	14.26	700	9.98K	3.92M
Aug 30, 2018	LILLY ELI & CO	SALE	14.35	3.44K	49.36K	3.92M
Aug 29, 2018	LILLY ELI & CO	SALE	14.26	2.31K	32.97K	3.92M
Aug 14, 2018	LILLY ELI & CO	SALE	14.28	3K	42.84K	3.93M
Aug 13, 2018	LILLY ELI & CO	SALE	14.33	4.53K	64.93K	3.93M
Aug 10, 2018	LILLY ELI & CO	SALE	14.28	1.9K	27.1K	3.93M
Aug 03, 2018	LILLY ELI & CO	SALE	13.55	1.65K	22.36K	3.94M
Aug 02, 2018	LILLY ELI & CO	SALE	13.31	19.4K	258.21K	3.94M

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES145.43K8

NET SHARES-145.43K8

SHARES HELD776.09K8

% NET SHARES-118.74%0%

ZYME Stock Ownership Breakdown

Zymeworks