How many institutions own XENE stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own XENE shares is 328, representing 112.54% of the company's common stock.

Who are the major shareholders selling Xenon Pharmaceuticals Inc. stock?

AFFINITY ASSET ADVISORS, LLC, in the last quarter, reduced its stake in XENE by -10.71% restricting it's holding to 1.25 million shares of worth nearly $56.03M. NUVEEN, LLC also lessened -3.59% of the XENE shares from its portfolio, reducing its holding to 216.24 thousand shares of worth $9.69M. DEEP TRACK CAPITAL, LP also shunned XENE shares holding by -69.46% last quarter which brought its holding to 366.44 thousand shares worth $16.42M.

Investors who are buying XENE stock?

As per its latest 13F filing, CAPITAL INTERNATIONAL INVESTORS increased its stake in XENE by 7.34% in the last quarter. The institutional holder raised its holding to 3.41 million shares having worth more than $153.06M. BLACKROCK, INC. also added 6.9% more shares of XENE to its portfolio, raising its holding to 5.1 million shares of worth $228.59M. PATIENT SQUARE CAPITAL LP also increased its XENE shares holding by 100% which brought its holding to 136.5 thousand shares worth $6.12M.

XENE's major insiders: who are they?

The insider with the most stakes in XENE is BVF PARTNERS L P/IL , 10 percent owner at the company. Additionally, XENE stock is highly held by director Hayden Michael R and director HOLLER FRANK A among others.

Did an insider recently sell XENE stock?

Company executives, directors, and other insiders own 0.11% percent of Xenon Pharmaceuticals Inc.'s stock. Within the last six months, there have been 5 transaction(s) in which XENE insiders have sold stock, totaling 43.54K shares. Insiders that have sold shares include MORTIMER IAN, GANNON STEVEN, and AULIN SHERRY.

Which insider recently purchased XENE stock?

There have been 0 transaction(s) during the past 6-months in which Xenon Pharmaceuticals Inc. insiders have bought stock, totalling 0 shares

How much of XENE does insiders own?

Around 91.34K Xenon Pharmaceuticals Inc. shares are held by insiders, which represents about 0.11% of XENE stock.

Who is the insider with the largest stake?

XENE 10 percent owner, BVF PARTNERS L P/IL holds the largest portfolio of the company's shares. XENE shares owned by BVF total nearly 1.08 million.

Which institution holds the most shares in XENE?

SIREN, L.L.C. is the largest institutional owner in XENE which holds 812.76 thousand shares worth $36.43M or 1.03% of the total XENE shares outstanding followed by CAPITAL INTERNATIONAL INVESTORS with ownership of 3.41 million shares representing 4.31% of the XENE ownership. BLACKROCK, INC. is the third largest stakeholder with 5.1 million shares or 6.44% of the ownership worth more than $228.59M.

Is Xenon Pharmaceuticals Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the XENE is concerned, it is a stock which is optionable.

Is there a short position on XENE's shares?

Number of XENE shares short is 6.91M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding XENE shares are there?

As of today, 77.11M shares of XENE are outstanding.

Is there many float in XENE stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, XENE has 71.60M shares in float.

XENE short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for XENE is 7.33.

Xenon Pharmaceuticals (XENE) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares8.96

Short Percent Of Float9.99

Shares Outstanding77.11M

Shares Float71.60M

Shares Short6.91M

Short Ratio7.33

9.99%

Short % of Float

8.96%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

0.11% Percentage of Shares held by All Insiders

112.54% Percentage of Shares held by All Institutions

112.67% Percentage of Float held by Institutions

328

Number of Institutions Holding Shares

Institutional Ownership

About 112.54% of XENE shares are held by financial institutions. SIREN, L.L.C. is the top corporate investor, holding 812.76K shares valued at $36.43M. A 1.03% stake in Xenon Pharmaceuticals Inc. is owned by the company. CAPITAL INTERNATIONAL INVESTORS owns 3.41M shares valued at $153.06M, which translates its holding of 4.31% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	SIREN, L.L.C.	1.03%	812.76K	36.43M	0	0
Dec 31, 2025	CAPITAL INTERNATIONAL INVESTORS	4.31%	3.41M	153.06M	233.47K	+7.34%
Dec 31, 2025	BLACKROCK, INC.	6.44%	5.1M	228.59M	329.33K	+6.90%
Dec 31, 2025	PATIENT SQUARE CAPITAL LP	0.17%	136.5K	6.12M	136.5K	+100.00%
Dec 31, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.18%	139K	6.23M	58K	+71.60%
Dec 31, 2025	NOMURA HOLDINGS INC	0.19%	150K	6.72M	150K	+100.00%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.19%	152.3K	6.83M	37.08K	+32.18%
Dec 31, 2025	WESTFIELD CAPITAL MANAGEMENT CO LP	1.55%	1.23M	54.98M	20.71K	+1.72%
Dec 31, 2025	AFFINITY ASSET ADVISORS, LLC	1.58%	1.25M	56.03M	-150K	-10.71%
Dec 31, 2025	JENNISON ASSOCIATES LLC	1.63%	1.29M	57.91M	156.82K	+13.81%
Dec 31, 2025		0.75%	597.09K	26.76B	597.09K	+100.00%
Dec 31, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.24%	186.71K	8.37M	15K	+8.73%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.24%	189.06K	8.47M	312	+0.17%
Dec 31, 2025	NUVEEN, LLC	0.27%	216.24K	9.69M	-8.05K	-3.59%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	0.28%	221.37K	9.92B	22.26K	+11.18%
Dec 31, 2025	NAN FUNG TRINITY (HK) LTD	0.29%	226.97K	10.17M	68.36K	+43.10%
Dec 31, 2025	NICHOLAS INVESTMENT PARTNERS, LP	0.31%	242.99K	10.89M	123.89K	+104.02%
Dec 31, 2025	TUDOR INVESTMENT CORP ET AL	0.32%	254K	11.38M	177.18K	+230.63%
Dec 31, 2025	TWO SIGMA ADVISERS, LP	0.33%	259.32K	11.62M	241.22K	+1,332.71%
Dec 31, 2025	DNB ASSET MANAGEMENT AS	0.34%	272.83K	12.23M	23.75K	+9.54%
Dec 31, 2025	DEEP TRACK CAPITAL, LP	0.46%	366.44K	16.42M	-833.57K	-69.46%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.49%	387.16K	17.35M	-31.26K	-7.47%
Dec 31, 2025	CANDRIAM S.C.A.	0.53%	417.4K	18.71M	20.77K	+5.24%
Dec 31, 2025	TWO SIGMA INVESTMENTS, LP	0.55%	436.74K	19.57M	436.74K	+100.00%
Dec 31, 2025	LOOMIS SAYLES & CO L P	0.77%	612.03K	27.43M	-28.59K	-4.46%
Dec 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.79%	625.99K	28.01M	-636.59K	-50.42%
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	0.8%	635.06K	28.46M	-748.95K	-54.11%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	0.88%	696.05K	31.2M	-24.61K	-3.42%
Dec 31, 2025	ABRDN PLC	0.95%	750.29K	33.63M	171.15K	+29.55%
Dec 31, 2025	FRANKLIN RESOURCES INC	0.96%	758.06K	33.98M	62.16K	+8.93%
Dec 31, 2025	FIRST TURN MANAGEMENT, LLC	1.01%	799.74K	35.84M	0	0
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.2%	952.68K	42.69M	-24.76K	-2.53%
Dec 31, 2025	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	1.34%	1.06M	47.52M	389.96K	+58.18%
Dec 31, 2025	STATE STREET CORP	1.88%	1.49M	66.9M	26.08K	+1.78%
Dec 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.57%	452.15K	20.26M	-1.88K	-0.41%
Dec 31, 2025	BIOIMPACT CAPITAL LLC	0.61%	485.62K	21.77M	-17.78K	-3.53%
Dec 31, 2025	CALIGAN PARTNERS LP	0.69%	549.67K	24.64M	105.1K	+23.64%
Dec 31, 2025	VESTAL POINT CAPITAL, LP	0.76%	600K	26.89M	-500K	-45.45%
Dec 31, 2025	BARCLAYS PLC	0.76%	600.96K	26.94M	489.66K	+439.95%
Dec 31, 2025	CAPITAL WORLD INVESTORS	0.83%	655.74K	29.39M	0	0
Dec 31, 2025	AMERICAN CENTURY COMPANIES INC	0.86%	680.47K	30.5M	21.22K	+3.22%
Dec 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.86%	685.1K	30.71M	-150K	-17.96%
Dec 31, 2025	FIERA CAPITAL CORP	0.87%	686.06K	30.75M	166.06K	+31.93%
Dec 31, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.99%	787.79K	35.31M	-63.96K	-7.51%
Dec 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	1.09%	862.3K	38.65M	820.61K	+1,968.26%
Dec 31, 2025	HOLOCENE ADVISORS, LP	1.62%	1.28M	57.46M	-694.47K	-35.14%
Dec 31, 2025	ALLIANCEBERNSTEIN L.P.	2.01%	1.59M	71.43M	-60.6K	-3.66%
Dec 31, 2025	COMMODORE CAPITAL LP	2.27%	1.8M	80.68M	-900K	-33.33%
Dec 31, 2025	BRAIDWELL LP	2.3%	1.83M	81.8M	-1.78M	-49.37%
Dec 31, 2025	POLAR CAPITAL HOLDINGS PLC	3.11%	2.47M	110.51M	-81.07K	-3.18%
Dec 31, 2025	JANUS HENDERSON GROUP PLC	5.15%	4.08M	183.11M	140.15K	+3.55%
Dec 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	5.73%	4.54M	203.42M	369.58K	+8.86%
Dec 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	6.01%	4.76M	213.56M	1.15M	+31.99%
Dec 31, 2025	AVORO CAPITAL ADVISORS LLC	6.84%	5.42M	243.12M	24.44K	+0.45%
Dec 31, 2025	FMR LLC	11.26%	8.92M	399.81M	1.34K	+0.02%
Dec 31, 2025	CITADEL ADVISORS LLC	1.67%	1.32M	59.22M	362.12K	+37.76%
Dec 31, 2025	NORTHERN TRUST CORP	0.55%	438.71K	19.66M	-59.43K	-11.93%
Dec 31, 2025	ORBIMED ADVISORS LLC	0.56%	447.2K	20.04M	27.6K	+6.58%
Dec 31, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.19%	154.18K	6.91M	-21.95K	-12.46%
Dec 31, 2025	LMR PARTNERS LLP	0.2%	155.8K	6.98M	155.8K	+100.00%
Dec 31, 2025	FORESITE CAPITAL MANAGEMENT IV, LLC	0.2%	160K	7.17M	0	0
Dec 31, 2025	MARSHALL WACE, LLP	0.21%	162.55K	7.29M	-449.43K	-73.44%
Dec 31, 2025	NEUBERGER BERMAN GROUP LLC	0.23%	178.75K	8.01M	6.39K	+3.71%
Dec 31, 2025	TIMESSQUARE CAPITAL MANAGEMENT, LLC	0.67%	532.74K	23.88M	-24.06K	-4.32%
Dec 31, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.68%	542.02K	24.29M	0	0
Dec 31, 2025	RHUMBLINE ADVISERS	0.11%	90.14K	4.04M	-16.65K	-15.59%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.12%	93.46K	4.19M	-65.78K	-41.31%
Dec 31, 2025	VERITION FUND MANAGEMENT LLC	0.12%	93.76K	4.2M	36.64K	+64.15%
Dec 31, 2025	SWISS NATIONAL BANK	0.14%	114K	5.11M	-12.4K	-9.81%
Dec 31, 2025	MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	0.15%	116.09K	5.2M	21.15K	+22.28%
Dec 31, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.15%	119.19K	5.34M	119.19K	+100.00%
Dec 31, 2025	PEREGRINE CAPITAL MANAGEMENT LLC	0.22%	174.85K	7.84M	174.85K	+100.00%
Dec 31, 2025	DEUTSCHE BANK AG\	0.24%	190.23K	8.53M	77.28K	+68.42%
Dec 31, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.36%	287.94K	12.91M	0	0
Dec 31, 2025	MORGAN STANLEY	0.37%	294.33K	13.19M	-72.24K	-19.71%
Dec 31, 2025	VANGUARD GROUP INC	0.84%	664.64K	29.79M	-186.75K	-21.93%
Dec 31, 2025	FEDERATED HERMES, INC.	0.85%	672.24K	30.13M	439.74K	+189.13%
Dec 31, 2025	JPMORGAN CHASE & CO	1.89%	1.49M	66.96M	95K	+6.79%
Dec 31, 2025	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	0.69%	547.61K	24.55M	-51.5K	-8.60%
Dec 31, 2025	UBS GROUP AG	0.07%	52.54K	2.35M	-54.21K	-50.78%
Dec 31, 2025	SOFINNOVA INVESTMENTS, INC.	0.08%	59.9K	2.68M	59.9K	+100.00%
Dec 31, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.08%	60.86K	2.73M	0	0
Dec 31, 2025	ALPS ADVISORS INC	0.08%	63.3K	2.84M	26K	+69.71%
Dec 31, 2025	LEGAL & GENERAL GROUP PLC	0.09%	70.27K	3.15M	-9.58K	-12.00%
Dec 31, 2025	Y-INTERCEPT (HONG KONG) LTD	0.09%	72.96K	3.27M	72.96K	+100.00%
Sep 30, 2025	SATURN V CAPITAL MANAGEMENT LLC	0.64%	503.7K	20.22M	35.34K	+7.54%
Sep 30, 2025	TRI LOCUM PARTNERS LP	0.46%	366.1K	14.7M	366.1K	+100.00%
Sep 30, 2025	TIMESSQUARE CAPITAL MANAGEMENT, LLC	0.71%	556.8K	22.36M	-14.44K	-2.53%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.84%	659.26K	26.47M	-20.6K	-3.03%
Sep 30, 2025	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	0.85%	670.26K	26.91M	9.18K	+1.39%
Sep 30, 2025	CAPITAL WORLD INVESTORS	0.83%	655.74K	26.33M	0	0
Sep 30, 2025	DNB ASSET MANAGEMENT AS	0.32%	249.08K	10M	14.92K	+6.37%
Sep 30, 2025	JAIN GLOBAL LLC	0.32%	252.38K	10.13M	252.38K	+100.00%
Sep 30, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.36%	287.94K	11.56M	0	0
Sep 30, 2025	CANDRIAM S.C.A.	0.5%	396.64K	15.92M	0	0
Sep 30, 2025	MORGAN STANLEY	0.46%	366.57K	14.72M	-21.02K	-5.42%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.53%	418.42K	16.8M	-17.6K	-4.04%
Sep 30, 2025	ORBIMED ADVISORS LLC	0.53%	419.6K	16.85M	-528.28K	-55.73%
Sep 30, 2025	CALIGAN PARTNERS LP	0.56%	444.57K	17.85M	444.57K	+100.00%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.58%	454.02K	18.22M	74.04K	+19.48%
Sep 30, 2025	NORTHERN TRUST CORP	0.63%	498.15K	20M	8.21K	+1.68%
Sep 30, 2025	ABRDN PLC	0.73%	579.15K	23.25M	57.65K	+11.06%
Sep 30, 2025	FRANKLIN RESOURCES INC	0.88%	695.9K	27.94M	29.43K	+4.42%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	0.91%	720.66K	28.93M	158.86K	+28.28%
Sep 30, 2025	FIRST TURN MANAGEMENT, LLC	1.01%	799.74K	32.11M	139.13K	+21.06%
Sep 30, 2025	SIREN, L.L.C.	1.03%	812.76K	32.63M	0	0
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.06%	835.1K	33.53M	-455K	-35.27%
Sep 30, 2025	VANGUARD GROUP INC	1.08%	851.39K	34.18M	-21.84K	-2.50%
Sep 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	1.08%	851.74K	34.2M	-79.94K	-8.58%
Sep 30, 2025	CITADEL ADVISORS LLC	1.21%	959.1K	38.51M	839.05K	+698.95%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.24%	977.44K	39.24M	7.09K	+0.73%
Sep 30, 2025	VESTAL POINT CAPITAL, LP	1.39%	1.1M	44.17M	-900K	-45.00%
Sep 30, 2025	JENNISON ASSOCIATES LLC	1.44%	1.14M	45.58M	438.85K	+63.02%
Sep 30, 2025	DEEP TRACK CAPITAL, LP	1.52%	1.2M	48.18M	-150K	-11.11%
Sep 30, 2025	WESTFIELD CAPITAL MANAGEMENT CO LP	1.53%	1.21M	48.42M	53.46K	+4.64%
Sep 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.6%	1.26M	50.58M	-211.87K	-14.37%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	1.75%	1.38M	55.57M	501.17K	+56.77%
Sep 30, 2025	JPMORGAN CHASE & CO	1.77%	1.4M	56.17M	142.45K	+11.34%
Sep 30, 2025	AFFINITY ASSET ADVISORS, LLC	1.77%	1.4M	56.21M	300K	+27.27%
Sep 30, 2025	STATE STREET CORP	1.86%	1.47M	58.88M	86.01K	+6.23%
Sep 30, 2025	ALLIANCEBERNSTEIN L.P.	2.1%	1.65M	66.42M	135.89K	+8.95%
Sep 30, 2025	HOLOCENE ADVISORS, LP	2.5%	1.98M	79.36M	167.08K	+9.23%
Sep 30, 2025	POLAR CAPITAL HOLDINGS PLC	3.23%	2.55M	102.25M	-156.49K	-5.79%
Sep 30, 2025	COMMODORE CAPITAL LP	3.42%	2.7M	108.41M	-325K	-10.74%
Sep 30, 2025	CAPITAL INTERNATIONAL INVESTORS	4.03%	3.18M	127.74M	-56	0.00%
Sep 30, 2025	BRAIDWELL LP	4.57%	3.61M	144.74M	0	0
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	4.57%	3.61M	144.94M	1.44M	+65.99%
Sep 30, 2025	JANUS HENDERSON GROUP PLC	5%	3.94M	158.31M	366.15K	+10.23%
Sep 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	5.28%	4.17M	167.39M	-166.53K	-3.84%
Sep 30, 2025	BLACKROCK, INC.	6.04%	4.77M	191.55M	-594.38K	-11.08%
Sep 30, 2025	AVORO CAPITAL ADVISORS LLC	6.84%	5.4M	216.81M	0	0
Sep 30, 2025	FMR LLC	11.3%	8.92M	358.09M	34.54K	+0.39%
Sep 30, 2025	FIERA CAPITAL CORP	0.66%	520K	20.88M	-10.68K	-2.01%
Sep 30, 2025	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	0.76%	599.11K	24.06M	522.17K	+678.65%
Sep 30, 2025	MARSHALL WACE, LLP	0.78%	611.98K	24.57M	-408.27K	-40.02%
Sep 30, 2025	LOOMIS SAYLES & CO L P	0.81%	640.63K	25.72M	-16.54K	-2.52%
Sep 30, 2025	ENVESTNET ASSET MANAGEMENT INC	0.05%	37.45K	1.5M	-1.96K	-4.96%
Sep 30, 2025	ATIKA CAPITAL MANAGEMENT LLC	0.05%	38K	1.53M	38K	+100.00%
Sep 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.05%	39K	1.51M	0	0
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.06%	44.22K	1.78M	-1.33K	-2.91%
Sep 30, 2025	NEO IVY CAPITAL MANAGEMENT	0.06%	49.84K	2M	49.84K	+100.00%
Sep 30, 2025	ERSTE ASSET MANAGEMENT GMBH	0.06%	50K	1.95M	0	0
Sep 30, 2025	STATE OF NEW JERSEY COMMON PENSION FUND D	0.07%	55.71K	2.24M	-6.06K	-9.81%
Sep 30, 2025	INVESCO LTD.	0.07%	56.06K	2.25M	-3.53K	-5.93%
Sep 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.08%	60.86K	2.44M	1.39K	+2.34%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.09%	69.89K	2.81M	17.76K	+34.06%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.1%	79.85K	3.21M	-1.94K	-2.38%
Sep 30, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.1%	81K	3.25M	46K	+131.43%
Sep 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.1%	81.16K	3.17M	-47.95K	-37.14%
Sep 30, 2025	MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	0.12%	94.94K	3.81M	-633	-0.66%
Sep 30, 2025	UBS GROUP AG	0.14%	106.74K	4.29M	-46.31K	-30.26%
Sep 30, 2025	RHUMBLINE ADVISERS	0.14%	106.79K	4.29M	-2.91K	-2.65%
Sep 30, 2025	BARCLAYS PLC	0.14%	111.3K	4.47M	-41.47K	-27.15%
Sep 30, 2025	DEUTSCHE BANK AG\	0.14%	112.95K	4.53M	8.42K	+8.05%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.15%	115.22K	4.63M	2.66K	+2.36%
Sep 30, 2025	SWISS NATIONAL BANK	0.16%	126.4K	5.07M	2.1K	+1.69%
Sep 30, 2025	NAN FUNG TRINITY (HK) LTD	0.2%	158.61K	6.37M	0	0
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.2%	159.24K	6.39M	141.39K	+792.39%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.22%	171.71K	6.89M	5.24K	+3.15%
Sep 30, 2025	NEUBERGER BERMAN GROUP LLC	0.22%	172.35K	6.92M	24.94K	+16.92%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.24%	188.75K	7.58M	-3.5K	-1.82%
Sep 30, 2025	NUVEEN, LLC	0.28%	224.29K	9.01M	-4.28K	-1.87%
Sep 30, 2025	FEDERATED HERMES, INC.	0.29%	232.5K	9.33M	0	0
Sep 30, 2025	BAKER BROS. ADVISORS LP	0.47%	370.21K	14.86M	0	0
Sep 30, 2025	BIOIMPACT CAPITAL LLC	0.64%	503.4K	20.21M	180K	+55.66%
Sep 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.69%	542.02K	21.76M	0	0
Jun 30, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.37%	287.94K	9.01M	14.2K	+5.19%
Jun 30, 2025	BLACKROCK, INC.	6.82%	5.37M	167.93M	3.33M	+163.51%
Jun 30, 2025	BRAIDWELL LP	4.58%	3.61M	112.84M	895.15K	+33.03%
Jun 30, 2025	POLAR CAPITAL HOLDINGS PLC	3.44%	2.7M	84.61M	80.22K	+3.06%
Jun 30, 2025	HOLOCENE ADVISORS, LP	2.3%	1.81M	56.64M	1.81M	+100.00%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	1.93%	1.52M	47.53B	189.14K	+14.23%
Jun 30, 2025	AFFINITY ASSET ADVISORS, LLC	1.4%	1.1M	34.43M	-228.18K	-17.18%
Jun 30, 2025	MARSHALL WACE, LLP	1.3%	1.02M	31.93M	262.11K	+34.57%
Jun 30, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.56%	436.97K	13.68M	195.77K	+81.16%
Jun 30, 2025	MORGAN STANLEY	0.49%	387.6K	12.13B	258.11K	+199.32%
Jun 30, 2025	DNB ASSET MANAGEMENT AS	0.3%	234.16K	7.33M	4.68K	+2.04%
Jun 30, 2025		0.29%	228.57K	7.15M	228.57K	+100.00%
Jun 30, 2025	PERCEPTIVE ADVISORS LLC	0.26%	200.79K	6.28M	-124.53K	-38.28%
Jun 30, 2025	GREAT POINT PARTNERS LLC	0.25%	200K	6.26M	-45.27K	-18.46%
Jun 30, 2025	FIRST LIGHT ASSET MANAGEMENT, LLC	0.24%	188.37K	5.9M	-439.54K	-70.00%
Jun 30, 2025	STATE OF WISCONSIN INVESTMENT BOARD	0.22%	174.85K	5.47M	77.7K	+79.98%
Jun 30, 2025	CAPTION MANAGEMENT, LLC	0.21%	166.2K	5.2M	166.2K	+100.00%
Jun 30, 2025	FORESITE CAPITAL MANAGEMENT IV, LLC	0.2%	160K	5.01M	160K	+100.00%
Jun 30, 2025	FORESITE CAPITAL MANAGEMENT VI LLC	0.2%	160K	5.01M	160K	+100.00%
Jun 30, 2025	NAN FUNG TRINITY (HK) LTD	0.2%	158.61K	4.96M	158.61K	+100.00%
Jun 30, 2025	FMR LLC	11.29%	8.88M	278.08M	596.86K	+7.20%
Jun 30, 2025	CAPITAL INTERNATIONAL INVESTORS	4.04%	3.18M	99.58M	92.82K	+3.01%
Jun 30, 2025	COMMODORE CAPITAL LP	3.84%	3.03M	94.68M	700K	+30.11%
Jun 30, 2025	DEEP TRACK CAPITAL, LP	1.72%	1.35M	42.26M	350K	+35.00%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.64%	1.29M	40.38M	-624.65K	-32.62%
Jun 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.69%	542.02K	16.97M	542.02K	+100.00%
Jun 30, 2025	FIERA CAPITAL CORP	0.67%	530.68K	16.61M	1.24K	+0.23%
Jun 30, 2025	SATURN V CAPITAL MANAGEMENT LLC	0.6%	468.36K	14.66M	54.65K	+13.21%
Jun 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.33%	259.5K	8.12M	131.96K	+103.46%
Jun 30, 2025	GRANAHAN INVESTMENT MANAGEMENT, LLC	0.31%	240.04K	7.51M	56.23K	+30.59%
Jun 30, 2025	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	0.84%	661.08K	20.69M	-42.71K	-6.07%
Jun 30, 2025	FIRST TURN MANAGEMENT, LLC	0.84%	660.62K	20.68M	-22.83K	-3.34%
Jun 30, 2025	TIMESSQUARE CAPITAL MANAGEMENT, LLC	0.73%	571.24K	17.88M	-174.31K	-23.38%
Jun 30, 2025	ABRDN PLC	0.66%	521.49K	16.32M	117.34K	+29.03%
Jun 30, 2025	CANDRIAM S.C.A.	0.5%	396.64K	12.42M	-58.01K	-12.76%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.48%	379.99K	11.9M	165.13K	+76.85%
Jun 30, 2025	BAKER BROS. ADVISORS LP	0.47%	370.21K	11.59M	22.8K	+6.56%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.46%	358.43K	11.22M	221.86K	+162.45%
Jun 30, 2025	BIOIMPACT CAPITAL LLC	0.41%	323.4K	10.12M	20K	+6.59%
Jun 30, 2025	ORBIMED ADVISORS LLC	1.2%	947.88K	29.67M	0	0
Jun 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	1.18%	931.68K	29.16M	0	0
Jun 30, 2025	JENNISON ASSOCIATES LLC	0.89%	696.38K	21.8M	-80.31K	-10.34%
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	0.86%	679.86K	21.28M	679.86K	+100.00%
Jun 30, 2025	LOOMIS SAYLES & CO L P	0.84%	657.17K	20.57M	-15.85K	-2.35%
Jun 30, 2025	CAPITAL WORLD INVESTORS	0.83%	655.74K	20.52M	-1.57M	-70.52%
Jun 30, 2025	NORTHERN TRUST CORP	0.62%	489.94K	15.34M	408.92K	+504.69%
Jun 30, 2025	AVORO CAPITAL ADVISORS LLC	6.86%	5.4M	169.02M	-341.67K	-5.95%
Jun 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	5.51%	4.34M	135.71M	-249.21K	-5.44%
Jun 30, 2025	JANUS HENDERSON GROUP PLC	4.55%	3.58M	112.01M	252.64K	+7.60%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	2.76%	2.17M	68.07M	-1.61M	-42.61%
Jun 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.87%	1.47M	46.15M	-3.17K	-0.21%
Jun 30, 2025	STATE STREET CORP	1.75%	1.38M	43.21M	1.07M	+351.69%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.71%	561.8K	17.58B	119.07K	+26.89%
Jun 30, 2025	VESTAL POINT CAPITAL, LP	2.54%	2M	62.6M	700K	+53.85%
Jun 30, 2025	JPMORGAN CHASE & CO	1.6%	1.26M	39.33M	-101.02K	-7.44%
Jun 30, 2025	WESTFIELD CAPITAL MANAGEMENT CO LP	1.46%	1.15M	36.08M	-238.77K	-17.16%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.23%	970.34K	30.37M	900.75K	+1,294.23%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	1.12%	882.84K	27.63M	648.78K	+277.19%
Jun 30, 2025	VANGUARD GROUP INC	1.11%	873.23K	27.33M	536.71K	+159.49%
Jun 30, 2025	SIREN, L.L.C.	1.03%	812.76K	25.44M	80K	+10.92%
Jun 30, 2025	FRANKLIN RESOURCES INC	0.85%	666.47K	20.86M	175.35K	+35.70%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.55%	436.02K	13.65M	184.87K	+73.61%
Jun 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.51%	404.38K	12.66M	340.82K	+536.14%
Mar 31, 2025	COMMODORE CAPITAL LP	2.95%	2.33M	78M	-415K	-15.15%
Mar 31, 2025	POLAR CAPITAL HOLDINGS PLC	3.33%	2.62M	88M	-74.62K	-2.77%
Mar 31, 2025	BRAIDWELL LP	3.44%	2.71M	90.92M	-204.09K	-7.00%
Mar 31, 2025	PERCEPTIVE ADVISORS LLC	0.41%	325.32K	10.91M	0	0
Mar 31, 2025	FIRST TURN MANAGEMENT, LLC	0.87%	683.45K	22.93M	-1.54K	-0.22%
Mar 31, 2025	CITADEL ADVISORS LLC	0.87%	687.09K	23.05M	359.79K	+109.92%
Mar 31, 2025	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	0.89%	703.8K	23.61M	40.09K	+6.04%
Mar 31, 2025	SIREN, L.L.C.	0.93%	732.76K	24.58M	-11.01K	-1.48%
Mar 31, 2025	JANUS HENDERSON GROUP PLC	4.23%	3.33M	113.91M	458.34K	+15.99%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	4.82%	3.79M	127.13M	11.59K	+0.31%
Mar 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	5.83%	4.58M	153.82M	64.26K	+1.42%
Mar 31, 2025	ALLIANCEBERNSTEIN L.P.	1.69%	1.33M	44.6M	-113.79K	-7.88%
Mar 31, 2025	WESTFIELD CAPITAL MANAGEMENT CO LP	1.77%	1.39M	46.68M	234.18K	+20.24%
Mar 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.88%	1.48M	49.58M	-18.89K	-1.26%
Mar 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	2.43%	1.91M	64.24M	51.28K	+2.75%
Mar 31, 2025	DEEP TRACK CAPITAL, LP	1.27%	1M	33.55M	830.87K	+491.25%
Mar 31, 2025	SAMLYN CAPITAL, LLC	1.29%	1.02M	34.1M	-1.46K	-0.14%
Mar 31, 2025	VESTAL POINT CAPITAL, LP	1.65%	1.3M	43.62M	490K	+60.49%
Mar 31, 2025	GREAT POINT PARTNERS LLC	0.31%	245.27K	8.23M	0	0
Mar 31, 2025	STEMPOINT CAPITAL LP	0.35%	274.63K	9.21M	-101.21K	-26.93%
Mar 31, 2025	BIOIMPACT CAPITAL LLC	0.39%	303.4K	10.18M	106.19K	+53.84%
Mar 31, 2025	STATE STREET CORP	0.39%	305.62K	10.25M	16.9K	+5.85%
Mar 31, 2025	ABRDN PLC	0.51%	404.15K	13.56M	120.26K	+42.36%
Mar 31, 2025	AVORO CAPITAL ADVISORS LLC	7.3%	5.74M	192.63M	75K	+1.32%
Mar 31, 2025	BLACKROCK, INC.	2.59%	2.04M	68.31M	-69.11K	-3.28%
Mar 31, 2025	BAKER BROS. ADVISORS LP	0.44%	347.41K	11.66M	-646.27K	-65.04%
Mar 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.47%	367.23K	12.32M	78.39K	+27.14%
Mar 31, 2025	FIRST LIGHT ASSET MANAGEMENT, LLC	0.8%	627.9K	21.07M	-532.68K	-45.90%
Mar 31, 2025	LOOMIS SAYLES & CO L P	0.86%	673.01K	22.58M	-14.13K	-2.06%
Mar 31, 2025	CAPITAL WORLD INVESTORS	2.83%	2.22M	74.64M	-69.82K	-3.04%
Mar 31, 2025	FIERA CAPITAL CORP	0.67%	529.44K	17.76M	-6.45K	-1.20%
Mar 31, 2025	FRANKLIN RESOURCES INC	0.62%	491.12K	16.48M	-84.47K	-14.68%
Mar 31, 2025	CANDRIAM S.C.A.	0.58%	454.65K	15.25M	-37.53K	-7.63%
Mar 31, 2025	VANGUARD GROUP INC	0.43%	336.51K	11.29M	-6.27K	-1.83%
Mar 31, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.35%	273.74K	9.18M	0	0
Mar 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.34%	267.14K	8.96M	82.56K	+44.73%
Mar 31, 2025	CAPTION MANAGEMENT, LLC	0.33%	256.7K	8.61M	256.7K	+100.00%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.32%	251.15K	8.43M	204.55K	+438.98%
Mar 31, 2025	TIMESSQUARE CAPITAL MANAGEMENT, LLC	0.95%	745.55K	25.01M	-103.3K	-12.17%
Mar 31, 2025	CAPITAL INTERNATIONAL INVESTORS	3.93%	3.09M	103.63M	541.52K	+21.26%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.56%	442.73K	14.85M	32.49K	+7.92%
Mar 31, 2025	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	1.01%	796.99K	26.74M	-640.85K	-44.57%
Mar 31, 2025	TWO SIGMA ADVISERS, LP	0.38%	298.8K	10.02M	100	+0.03%
Mar 31, 2025	SATURN V CAPITAL MANAGEMENT LLC	0.53%	413.71K	13.88M	91.24K	+28.29%
Mar 31, 2025	JPMORGAN CHASE & CO	1.73%	1.36M	45.55M	707	+0.05%
Mar 31, 2025	MARSHALL WACE, LLP	0.96%	758.15K	25.44M	-141.57K	-15.74%
Mar 31, 2025	JENNISON ASSOCIATES LLC	0.99%	776.69K	26.06M	-24.86K	-3.10%
Mar 31, 2025	AFFINITY ASSET ADVISORS, LLC	1.69%	1.33M	44.56M	166.94K	+14.38%
Mar 31, 2025	FMR LLC	10.53%	8.29M	278.05M	762.21K	+10.13%
Mar 31, 2025	ORBIMED ADVISORS LLC	1.2%	947.88K	31.8M	0	0
Mar 31, 2024	INVESCO LTD.	1.57%	1.05M	45.18M	329.81K	+45.82%
Mar 31, 2024	ROCK SPRINGS CAPITAL MANAGEMENT LP	1.88%	1.26M	54.05M	0	0
Mar 31, 2024	CITADEL ADVISORS LLC	1.92%	1.29M	55.41M	20.23K	+1.60%
Mar 31, 2024	FIRST LIGHT ASSET MANAGEMENT, LLC	1.97%	1.32M	56.83M	-325.32K	-19.77%
Mar 31, 2024	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	2.13%	1.43M	61.4M	535.19K	+60.06%
Mar 31, 2024	MARSHALL WACE, LLP	2.17%	1.45M	62.44M	-78.31K	-5.12%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	2.2%	1.47M	63.22M	-106.12K	-6.74%
Mar 31, 2024	PICTET ASSET MANAGEMENT HOLDING SA	2.27%	1.52M	65.24M	-524.97K	-25.73%
Mar 31, 2024	ADAGE CAPITAL PARTNERS GP, L.L.C.	2.5%	1.67M	71.98M	623.19K	+59.42%
Mar 31, 2024	BLACKROCK INC.	3.17%	2.12M	91.35M	54.87K	+2.65%
Mar 31, 2024	COMMODORE CAPITAL LP	3.24%	2.17M	93.32M	0	0
Mar 31, 2024	CAPITAL INTERNATIONAL INVESTORS	3.7%	2.48M	106.59M	20.18K	+0.82%
Mar 31, 2024	PARADIGM BIOCAPITAL ADVISORS LP	3.71%	2.48M	106.97M	357.47K	+16.80%
Mar 31, 2024	POLAR CAPITAL HOLDINGS PLC	3.91%	2.61M	112.45M	-454.52K	-14.82%
Mar 31, 2024	DRIEHAUS CAPITAL MANAGEMENT LLC	6.46%	4.32M	186.05M	-23.44K	-0.54%
Mar 31, 2024	AVORO CAPITAL ADVISORS LLC	8.47%	5.67M	243.95M	0	0
Mar 31, 2024	MORGAN STANLEY	0.58%	386.2K	16.63M	161.05K	+71.53%
Mar 31, 2024	BRAIDWELL LP	1.96%	1.31M	56.31M	-339.3K	-20.60%
Mar 31, 2024	CAPITAL WORLD INVESTORS	4.01%	2.68M	115.44M	0	0
Mar 31, 2024	FMR LLC	9.87%	6.6M	284.21M	945.91K	+16.72%
Mar 31, 2024	WELLINGTON MANAGEMENT GROUP LLP	5.86%	3.92M	168.84M	-240.6K	-5.78%
Mar 31, 2024	PRUDENTIAL FINANCIAL INC	0.09%	59K	2.54M	0	0
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	0.1%	64.23K	2.77M	2.16K	+3.47%
Mar 31, 2024	JEFFERIES FINANCIAL GROUP INC.	0.1%	65.64K	2.83M	-1.09K	-1.63%
Mar 31, 2024	SILVERARC CAPITAL MANAGEMENT, LLC	0.1%	66.09K	2.85M	-97.08K	-59.50%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.1%	66.91K	2.88M	251	+0.38%
Mar 31, 2024	CREDIT SUISSE AG/	0.13%	85.34K	3.67M	3.54K	+4.33%
Mar 31, 2024	SCHRODER INVESTMENT MANAGEMENT GROUP	0.14%	91.5K	3.94M	0	0
Mar 31, 2024	STATE OF WISCONSIN INVESTMENT BOARD	0.14%	91.79K	3.95M	-3.55K	-3.72%
Mar 31, 2024	NAN FUNG GROUP HOLDINGS LTD	0.16%	106.68K	4.59M	0	0
Mar 31, 2024	ATIKA CAPITAL MANAGEMENT LLC	0.18%	122K	5.25M	28.77K	+30.85%
Mar 31, 2024	SWISS NATIONAL BANK	0.19%	123.8K	5.33M	0	0
Mar 31, 2024	DNB ASSET MANAGEMENT AS	0.19%	126.25K	5.44M	-125	-0.10%
Mar 31, 2024	PFM HEALTH SCIENCES, LP	0.23%	150.55K	6.48M	-42.3K	-21.93%
Mar 31, 2024	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.23%	154.04K	6.63M	-11.23K	-6.79%
Mar 31, 2024	ENSIGN PEAK ADVISORS, INC	0.24%	163.06K	7.02M	-1.32K	-0.80%
Mar 31, 2024	NICHOLAS INVESTMENT PARTNERS, LP	0.25%	167.93K	7.23M	80.17K	+91.36%
Mar 31, 2024	RUSSELL INVESTMENTS GROUP, LTD.	0.27%	178.1K	7.67M	3.81K	+2.19%
Mar 31, 2024	ALGERT GLOBAL LLC	0.28%	184.02K	7.92M	-33.31K	-15.33%
Mar 31, 2024	ASSENAGON ASSET MANAGEMENT S.A.	0.28%	186.61K	8.03M	86.88K	+87.11%
Mar 31, 2024	NEW YORK STATE COMMON RETIREMENT FUND	0.29%	192.75K	8.3M	2.44K	+1.28%
Mar 31, 2024	BALYASNY ASSET MANAGEMENT L.P.	0.3%	201.27K	8.66M	185.42K	+1,169.79%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.41%	274.63K	11.82M	-65.39K	-19.23%
Mar 31, 2024	POINT72 ASSET MANAGEMENT, L.P.	0.41%	275.86K	11.88M	-599.21K	-68.48%
Mar 31, 2024	BOONE CAPITAL MANAGEMENT LLC	0.44%	291.4K	12.54M	35.97K	+14.08%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.45%	299.77K	12.91M	-76.53K	-20.34%
Mar 31, 2024	ALLY BRIDGE GROUP (NY) LLC	0.46%	309.37K	13.32M	67.41K	+27.86%
Mar 31, 2024	VANGUARD GROUP INC	0.5%	335.64K	14.45M	12.14K	+3.75%
Mar 31, 2024	WESTFIELD CAPITAL MANAGEMENT CO LP	0.52%	347.35K	14.95M	109.86K	+46.26%
Mar 31, 2024	ALTIUM CAPITAL MANAGEMENT LP	0.52%	348K	14.98M	57.47K	+19.78%
Mar 31, 2024	SAMLYN CAPITAL, LLC	0.59%	396.2K	17.06M	-24.96K	-5.93%
Mar 31, 2024	VESTAL POINT CAPITAL, LP	0.6%	400K	17.22M	225K	+128.57%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	0.61%	410.21K	17.66M	7.54K	+1.87%
Mar 31, 2024	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	0.62%	416.74K	17.94M	416.74K	+100.00%
Mar 31, 2024	GREAT POINT PARTNERS LLC	0.68%	456.15K	19.64M	-143.85K	-23.98%
Mar 31, 2024	FRANKLIN RESOURCES INC	0.81%	542.29K	23.35M	248.46K	+84.56%
Mar 31, 2024	ORBIMED ADVISORS LLC	0.82%	550K	23.68M	0	0
Mar 31, 2024	CANDRIAM S.C.A.	0.84%	560.88K	24.15M	30K	+5.65%
Mar 31, 2024	JENNISON ASSOCIATES LLC	0.84%	563.95K	24.28M	-2.44K	-0.43%
Mar 31, 2024	FIERA CAPITAL CORP	0.86%	576.54K	24.82M	23.51K	+4.25%
Mar 31, 2024	BOXER CAPITAL, LLC	0.9%	600K	25.83M	0	0
Mar 31, 2024	FIRST TURN MANAGEMENT, LLC	1.02%	680.39K	29.29M	0	0
Mar 31, 2024	LOOMIS SAYLES & CO L P	1.03%	686.51K	29.55M	-21.79K	-3.08%
Mar 31, 2024	AVIDITY PARTNERS MANAGEMENT LP	1.06%	710K	30.57M	-105.99K	-12.99%
Mar 31, 2024	FEDERATED HERMES, INC.	1.1%	734.9K	31.64M	388.3K	+112.03%
Mar 31, 2024	TIMESSQUARE CAPITAL MANAGEMENT, LLC	1.1%	737.17K	31.74M	-56.78K	-7.15%
Mar 31, 2024	AFFINITY ASSET ADVISORS, LLC	1.25%	837.39K	36.05M	377.39K	+82.04%
Mar 31, 2024	PERCEPTIVE ADVISORS LLC	1.33%	892.21K	38.41M	-208.54K	-18.95%
Mar 31, 2024	LORD, ABBETT & CO. LLC	1.34%	895.2K	38.54M	177.22K	+24.68%
Mar 31, 2024	JANUS HENDERSON GROUP PLC	1.41%	941.57K	40.55M	-24.5K	-2.54%
Mar 31, 2024	BAKER BROS. ADVISORS LP	1.49%	993.68K	42.78M	0	0
Mar 31, 2024	ARTAL GROUP S.A.	0.38%	253.39K	10.91M	253.39K	+100.00%
Mar 31, 2024	ALPS ADVISORS INC	0.08%	53.2K	2.29M	2.42K	+4.77%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.08%	55.01K	2.37B	1.36K	+2.54%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.08%	56.4K	2.43M	23.8K	+73.01%
Mar 31, 2024	STATE OF NEW JERSEY COMMON PENSION FUND D	0.08%	56.75K	2.44M	-14.26K	-20.09%
Mar 31, 2024	WELLS FARGO & COMPANY/MN	0.09%	61.46K	2.65M	3.03K	+5.19%
Dec 31, 2023	POINT72 ASSET MANAGEMENT, L.P.	1.33%	875.07K	40.31M	-250.64K	-22.27%
Dec 31, 2023	BVF INC/IL	1.35%	890.07K	41M	-937.89K	-51.31%
Dec 31, 2023	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	1.35%	891.15K	41.05M	891.15K	+100.00%
Dec 31, 2023	JANUS HENDERSON GROUP PLC	1.46%	966.07K	44.48M	583.76K	+152.69%
Dec 31, 2023	BAKER BROS. ADVISORS LP	1.51%	993.68K	45.77M	242.04K	+32.20%
Dec 31, 2023	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.59%	1.05M	48.3M	498.73K	+90.68%
Dec 31, 2023	PERCEPTIVE ADVISORS LLC	1.67%	1.1M	50.7M	483.25K	+78.26%
Dec 31, 2023	GREAT POINT PARTNERS LLC	0.91%	600K	27.64M	100K	+20.00%
Dec 31, 2023	BOXER CAPITAL, LLC	0.91%	600K	27.64M	0	0
Dec 31, 2023	JENNISON ASSOCIATES LLC	0.86%	566.4K	26.09M	352.57K	+164.89%
Dec 31, 2023	FIERA CAPITAL CORP	0.84%	553.03K	25.47M	-7.52K	-1.34%
Dec 31, 2023	ORBIMED ADVISORS LLC	0.83%	550K	25.33M	-408.79K	-42.64%
Dec 31, 2023	CANDRIAM S.C.A.	0.8%	530.88K	24.45M	-39K	-6.84%
Dec 31, 2023	AFFINITY ASSET ADVISORS, LLC	0.7%	460K	21.19M	159.56K	+53.11%
Dec 31, 2023	SAMLYN CAPITAL, LLC	0.64%	421.16K	19.4M	-530.6K	-55.75%
Dec 31, 2023	ROCK SPRINGS CAPITAL MANAGEMENT LP	1.9%	1.26M	57.83M	77.58K	+6.59%
Dec 31, 2023	CITADEL ADVISORS LLC	1.92%	1.27M	58.35M	543.32K	+75.09%
Dec 31, 2023	MARSHALL WACE, LLP	2.32%	1.53M	70.41M	-625.75K	-29.05%
Dec 31, 2023	ALLIANCEBERNSTEIN L.P.	2.39%	1.57M	72.52M	490.23K	+45.21%
Dec 31, 2023	FIRST LIGHT ASSET MANAGEMENT, LLC	2.49%	1.65M	75.79M	1.04M	+173.31%
Dec 31, 2023	BRAIDWELL LP	2.5%	1.65M	75.88M	-456.09K	-21.68%
Dec 31, 2023	BLACKROCK INC.	3.13%	2.07M	95.21M	1.08M	+108.49%
Dec 31, 2023	AVORO CAPITAL ADVISORS LLC	8.59%	5.67M	261.01M	766.67K	+15.65%
Dec 31, 2023	PARADIGM BIOCAPITAL ADVISORS LP	3.22%	2.13M	97.99M	635.57K	+42.60%
Dec 31, 2023	COMMODORE CAPITAL LP	3.28%	2.17M	99.85M	322.79K	+17.50%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	0.61%	402.67K	18.55M	-24.46K	-5.73%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.57%	376.3K	17.33M	120.93K	+47.36%
Dec 31, 2023	CAPITAL INTERNATIONAL INVESTORS	3.72%	2.46M	113.11M	8.86K	+0.36%
Dec 31, 2023	CAPITAL WORLD INVESTORS	4.06%	2.68M	123.51M	406.56K	+17.87%
Dec 31, 2023	FEDERATED HERMES, INC.	0.53%	346.6K	15.96M	346.6K	+100.00%
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	0.52%	340.02K	15.66M	259.38K	+321.68%
Dec 31, 2023	VANGUARD GROUP INC	0.49%	323.5K	14.9M	56.67K	+21.24%
Dec 31, 2023	GRANAHAN INVESTMENT MANAGEMENT, LLC	0.46%	302.58K	13.94M	66.29K	+28.05%
Dec 31, 2023	CAPTION MANAGEMENT, LLC	0.46%	301.2K	13.87M	223.7K	+288.65%
Dec 31, 2023	PARKMAN HEALTHCARE PARTNERS LLC	0.45%	294.79K	13.58M	78.14K	+36.07%
Dec 31, 2023	FRANKLIN RESOURCES INC	0.45%	293.83K	13.53M	121.21K	+70.22%
Dec 31, 2023	ALTIUM CAPITAL MANAGEMENT LP	0.44%	290.54K	13.38M	62.54K	+27.43%
Dec 31, 2023	DAFNA CAPITAL MANAGEMENT LLC	0.42%	276.74K	12.75M	-3.8K	-1.35%
Dec 31, 2023	BOONE CAPITAL MANAGEMENT LLC	0.39%	255.43K	11.77M	255.43K	+100.00%
Dec 31, 2023	POLAR CAPITAL HOLDINGS PLC	4.65%	3.07M	141.25M	62.88K	+2.09%
Dec 31, 2023	WELLINGTON MANAGEMENT GROUP LLP	6.31%	4.16M	191.73M	4.16M	+100.00%
Dec 31, 2023	DRIEHAUS CAPITAL MANAGEMENT LLC	6.58%	4.35M	200.14M	-167.83K	-3.72%
Dec 31, 2023	FMR LLC	8.57%	5.66M	260.51M	1.4M	+32.99%
Dec 31, 2023		1.03%	680.39K	31.34M	680.39K	+100.00%
Dec 31, 2023	LOOMIS SAYLES & CO L P	1.07%	708.3K	32.62M	-22.42K	-3.07%
Dec 31, 2023	LORD, ABBETT & CO. LLC	1.09%	717.97K	33.07M	-431.2K	-37.52%
Dec 31, 2023	INVESCO LTD.	1.09%	719.72K	33.15M	3.42K	+0.48%
Dec 31, 2023	TIMESSQUARE CAPITAL MANAGEMENT, LLC	1.2%	793.95K	36.57M	203.38K	+34.44%
Dec 31, 2023	AVIDITY PARTNERS MANAGEMENT LP	1.24%	815.99K	37.58M	494.59K	+153.89%

Insiders

Among the XENE insiders holding of 0.11% of the stake in company, BVF PARTNERS L P/IL, 10 percent owner, holds the largest shares of 1.08M. HAYDEN MICHAEL R, director, is the second largest XENE insider with ownership of 161.19K shares. HOLLER FRANK A, director, stands third with possession of 143.65K shares of that stake.

Insiders	Designation	Shares Held
BVF PARTNERS L P/IL	10 percent owner	1.08M
HAYDEN MICHAEL R	director	161.19K
HOLLER FRANK A	director	143.65K
AZAB MOHAMMAD	director	57.56K
SVORONOS DAWN	director	25K
PATOU GARY	director	23.57K
EMPFIELD JAMES R.	EVP, Drug Discovery	10K
ROBIN SHERRINGTON	EVP, Strategy & Innovation	8.4K
GANNON STEVEN	director	7.14K
SCHELLER RICHARD H	director	7K
MORTIMER IAN	PRESIDENT & CEO	6K
PIMSTONE SIMON N.	director	6K
VON SEGGERN CHRISTOPHER	Chief Commercial Officer	4K
WINQUIST RAYMOND	Head, Translational Research	1K
KENNEY CHRISTOPHER JOHN	Chief Medical Officer	0
GAROFALO ELIZABETH A.	director	0
AULIN SHERRY	Chief Financial Officer	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Jan 02, 2026	MORTIMER IAN	SALE	44.93	2.06K	92.65K	6K
Dec 08, 2025	MORTIMER IAN	SALE	46.32	2.01K	93.1K	6K
Dec 05, 2025	MORTIMER IAN	SALE	45.03	14.38K	647.31K	16.83K
Nov 28, 2025	MORTIMER IAN	SALE	45.01	97	4.37K	31.21K
Oct 01, 2025	MORTIMER IAN	SALE	40.16	25K	1M	31.3K
Jun 05, 2025	GANNON STEVEN	SALE	30.48	3	91.44	7.14K
Jan 27, 2025	MORTIMER IAN	SALE	41.07	1.15K	47.19K	31.3K
Jan 24, 2025	MORTIMER IAN	SALE	40.20	22.47K	903.21K	31.3K
Jan 23, 2025	MORTIMER IAN	SALE	40.08	16.22K	649.98K	31.3K
Dec 18, 2024	AULIN SHERRY	SALE	41.19	11.51K	474.1K	0
Nov 22, 2024	PATOU GARY	SALE	41.05	2.04K	83.74K	23.57K
Mar 08, 2024	GAROFALO ELIZABETH A.	SALE	45.69	2.09K	95.58K	0
Mar 07, 2024	GANNON STEVEN	SALE	46.20	2K	92.4K	2K
Mar 07, 2024	ROBIN SHERRINGTON	SALE	46.30	6.12K	283.26K	8.4K
Dec 14, 2023	PATOU GARY	SALE	41.05	7.6K	311.9K	4.9K
Dec 13, 2023	PATOU GARY	SALE	41.05	7.6K	311.9K	4.9K
Aug 24, 2023	SVORONOS DAWN	SALE	38.70	25K	967.5K	25K
Jun 01, 2023	PIMSTONE SIMON N.	SALE	38.78	24.26K	940.61K	6K
May 31, 2023	PIMSTONE SIMON N.	SALE	38.69	26.86K	1.04M	6K
May 30, 2023	PIMSTONE SIMON N.	SALE	39.90	19K	758.1K	18K
May 24, 2023	MORTIMER IAN	SALE	41.44	17.07K	707.34K	24.21K
Mar 24, 2023	KENNEY CHRISTOPHER JOHN	SALE	35.01	700	24.51K	0
Mar 07, 2023	PIMSTONE SIMON N.	SALE	37.01	10.99K	406.74K	34K
Nov 25, 2022	PATOU GARY	SALE	34.79	1.94K	67.39K	23.57K
Sep 02, 2022	AULIN SHERRY	SALE	39.57	15.36K	607.6K	0
Sep 01, 2022	ROBIN SHERRINGTON	SALE	38.03	35.1K	1.33M	25.57K
Aug 31, 2022	ROBIN SHERRINGTON	SALE	38.57	21.35K	823.55K	16.8K
Aug 12, 2022	EMPFIELD JAMES R.	SALE	38.68	21.88K	846.13K	10K
Aug 12, 2022	PIMSTONE SIMON N.	SALE	38.29	32.06K	1.23M	26K
Mar 08, 2022	PIMSTONE SIMON N.	SALE	30.80	2.5K	77K	193.14K
Mar 07, 2022	EMPFIELD JAMES R.	SALE	30.54	31.05K	948.21K	10K
Mar 04, 2022	PIMSTONE SIMON N.	SALE	30.20	2.5K	75.5K	188.14K
Mar 04, 2022	EMPFIELD JAMES R.	SALE	30.79	18.32K	563.92K	10K
Mar 04, 2022	ROBIN SHERRINGTON	SALE	30.23	5K	151.15K	17.23K
Jan 21, 2022	KENNEY CHRISTOPHER JOHN	PURCHASE	28.81	700	20.17K	700
Dec 06, 2021	VON SEGGERN CHRISTOPHER	PURCHASE	24.40	4K	97.6K	4K
Nov 15, 2021	PIMSTONE SIMON N.	SALE	31.33	17.56K	550.06K	210.19K
May 28, 2021	ROBIN SHERRINGTON	SALE	18.81	2.91K	54.77K	32.23K
May 27, 2021	HOLLER FRANK A	SALE	18.68	8.49K	158.5K	143.65K
Jun 01, 2020	PIMSTONE SIMON N.	SALE	14.43	3K	43.29K	255.19K
May 29, 2020	PIMSTONE SIMON N.	SALE	13.99	5K	69.95K	258.19K
Sep 20, 2019	HOLLER FRANK A	SALE	9.39	5.21K	48.88K	118.96K
Sep 20, 2019	PIMSTONE SIMON N.	SALE	9.51	10.4K	98.86K	258.12K
Sep 19, 2019	HOLLER FRANK A	SALE	9.27	7.6K	70.45K	124.16K
Sep 18, 2019	HOLLER FRANK A	SALE	9.28	4.37K	40.54K	131.76K
Sep 17, 2019	HOLLER FRANK A	SALE	9.32	5.07K	47.24K	136.13K
Sep 13, 2019	AZAB MOHAMMAD	SALE	9.31	23	214.18	57.56K
Nov 15, 2017	AZAB MOHAMMAD	PURCHASE	2.22	15K	33.28K	44.21K
Sep 22, 2017	AZAB MOHAMMAD	PURCHASE	2.95	8K	23.6K	29.21K
Sep 21, 2017	AZAB MOHAMMAD	PURCHASE	2.95	2K	5.9K	21.21K
Aug 18, 2017	WINQUIST RAYMOND	PURCHASE	3.00	1K	3K	1K
Aug 18, 2017	AZAB MOHAMMAD	PURCHASE	2.90	6.31K	18.3K	19.21K
Aug 17, 2017	AZAB MOHAMMAD	PURCHASE	2.65	23	60.95	12.9K
Aug 15, 2017	BVF PARTNERS L P/IL	PURCHASE	2.41	7.43K	17.92K	1.08M
Aug 15, 2017	EMPFIELD JAMES R.	PURCHASE	2.48	10K	24.82K	10K
Aug 14, 2017	HAYDEN MICHAEL R	PURCHASE	2.75	15K	41.25K	161.19K
Aug 14, 2017	SVORONOS DAWN	PURCHASE	2.82	50K	140.77K	50K
Aug 14, 2017	BVF PARTNERS L P/IL	PURCHASE	2.70	13.34K	36.06K	1.07M
Aug 11, 2017	GANNON STEVEN	PURCHASE	2.82	15K	42.27K	15K
Aug 10, 2017	PATOU GARY	PURCHASE	2.78	7.5K	20.84K	12.5K
Aug 10, 2017	PIMSTONE SIMON N.	PURCHASE	2.90	6K	17.4K	217.85K
Aug 10, 2017	SCHELLER RICHARD H	PURCHASE	2.85	7K	19.95K	7K
Aug 10, 2017	MORTIMER IAN	PURCHASE	2.85	5K	14.23K	6K
Aug 08, 2017	PATOU GARY	PURCHASE	3.00	5K	15K	5K
Jun 27, 2017	BVF PARTNERS L P/IL	PURCHASE	4.00	8.5K	33.98K	297.46K
Jun 22, 2017	BVF PARTNERS L P/IL	PURCHASE	4.00	854	3.42K	288.97K
Jun 21, 2017	BVF PARTNERS L P/IL	PURCHASE	4.00	1.36K	5.45K	288.11K
Jun 19, 2017	BVF PARTNERS L P/IL	PURCHASE	3.85	357	1.37K	286.75K
Jun 16, 2017	BVF PARTNERS L P/IL	PURCHASE	3.85	1.06K	4.1K	286.4K
Jun 15, 2017	BVF PARTNERS L P/IL	PURCHASE	3.84	1.16K	4.45K	285.33K
Jun 07, 2017	BVF PARTNERS L P/IL	PURCHASE	3.85	113.45K	436.9K	1.56M

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES43.54K5

NET SHARES-43.54K5

SHARES HELD91.34K5

% NET SHARES-147.67%0%

Frequently Asked Questions