| Sep 30, 2025 | BARCLAYS PLC | 0.26% | 208.25K | 4.49M | -22.86K | -9.89% |
| Sep 30, 2025 | BLACKROCK, INC. | 6.65% | 5.43M | 117.15M | -92.51K | -1.68% |
| Sep 30, 2025 | FMR LLC | 15.01% | 12.25M | 264.34M | 10.55K | +0.09% |
| Sep 30, 2025 | COMMODORE CAPITAL LP | 3.92% | 3.2M | 69.06M | -1.68M | -34.36% |
| Sep 30, 2025 | ALPS ADVISORS INC | 0.05% | 39.96K | 862.36K | -4.01K | -9.12% |
| Sep 30, 2025 | METLIFE INVESTMENT MANAGEMENT, LLC | 0.05% | 43.63K | 941.51K | 0 | 0 |
| Sep 30, 2025 | SIMPLIFY ASSET MANAGEMENT INC. | 0.06% | 50K | 1.08M | 50K | +100.00% |
| Sep 30, 2025 | AMERICAN CENTURY COMPANIES INC | 0.06% | 51.24K | 1.11M | -53.33K | -51.00% |
| Sep 30, 2025 | J. SAFRA SARASIN HOLDING AG | 0.06% | 51.7K | 1.12M | -119.42K | -69.79% |
| Sep 30, 2025 | KNIGHTS OF COLUMBUS ASSET ADVISORS LLC | 0.07% | 59.41K | 1.28M | 1.39K | +2.39% |
| Sep 30, 2025 | LEGAL & GENERAL GROUP PLC | 0.07% | 59.98K | 1.29M | 0 | 0 |
| Sep 30, 2025 | DCF ADVISERS, LLC | 0.08% | 62.03K | 1.34M | 0 | 0 |
| Sep 30, 2025 | SG AMERICAS SECURITIES, LLC | 0.08% | 62.12K | 1.34M | 49.98K | +411.81% |
| Sep 30, 2025 | Y-INTERCEPT (HONG KONG) LTD | 0.08% | 64.59K | 1.39M | 52.41K | +430.33% |
| Sep 30, 2025 | RAFFERTY ASSET MANAGEMENT, LLC | 0.08% | 68.07K | 1.47M | -8.35K | -10.92% |
| Sep 30, 2025 | MOODY ALDRICH PARTNERS LLC | 0.09% | 74.11K | 1.6M | -15.05K | -16.88% |
| Sep 30, 2025 | TD ASSET MANAGEMENT INC | 0.1% | 78.8K | 1.7M | -10.8K | -12.05% |
| Sep 30, 2025 | INVESCO LTD. | 0.1% | 80.79K | 1.74M | 18.58K | +29.86% |
| Sep 30, 2025 | PROPEL BIO MANAGEMENT, LLC | 0.11% | 90K | 1.94M | 90K | +100.00% |
| Sep 30, 2025 | MERCK & CO., INC. | 0.11% | 93.41K | 2.02M | 0 | 0 |
| Sep 30, 2025 | RHUMBLINE ADVISERS | 0.13% | 104.36K | 2.25M | -3.03K | -2.82% |
| Sep 30, 2025 | WELLS FARGO & COMPANY/MN | 0.13% | 105.88K | 2.28M | 26.1K | +32.71% |
| Sep 30, 2025 | MAVERICK CAPITAL LTD | 2.71% | 2.21M | 47.75M | -44.31K | -1.96% |
| Sep 30, 2025 | SWISS NATIONAL BANK | 0.14% | 110.7K | 2.39M | 1.8K | +1.65% |
| Sep 30, 2025 | KNOTT DAVID M JR | 0.14% | 116.57K | 2.52M | 25.09K | +27.43% |
| Sep 30, 2025 | RUSSELL INVESTMENTS GROUP, LTD. | 0.17% | 135K | 2.91M | 47.11K | +53.61% |
| Sep 30, 2025 | HENNION & WALSH ASSET MANAGEMENT, INC. | 0.19% | 154.34K | 3.33M | -13.99K | -8.31% |
| Sep 30, 2025 | MACQUARIE GROUP LTD | 0.19% | 154.74K | 3.34M | -2.43K | -1.54% |
| Sep 30, 2025 | NUVEEN, LLC | 0.2% | 161.87K | 3.49M | -61.37K | -27.49% |
| Sep 30, 2025 | HUDSON BAY CAPITAL MANAGEMENT LP | 0.21% | 175.25K | 3.78M | 55.69K | +46.58% |
| Sep 30, 2025 | KOPP FAMILY OFFICE, LLC | 0.24% | 193.83K | 4.18M | -9.4K | -4.63% |
| Sep 30, 2025 | BANK OF NEW YORK MELLON CORP | 0.24% | 197.17K | 4.25M | 4.65K | +2.41% |
| Sep 30, 2025 | DEEP TRACK CAPITAL, LP | 6.59% | 5.38M | 116.11M | 0 | 0 |
| Sep 30, 2025 | PRINCIPAL FINANCIAL GROUP INC | 0.26% | 213.33K | 4.6M | 9.49K | +4.66% |
| Sep 30, 2025 | NOVO HOLDINGS A/S | 2.92% | 2.38M | 51.36M | 0 | 0 |
| Sep 30, 2025 | BNP PARIBAS ARBITRAGE, SNC | 0.3% | 242.31K | 5.23M | 52.08K | +27.38% |
| Sep 30, 2025 | TANG CAPITAL MANAGEMENT LLC | 3.48% | 2.84M | 61.35M | 0 | 0 |
| Sep 30, 2025 | PARADIGM BIOCAPITAL ADVISORS LP | 3.2% | 2.61M | 56.31M | -132.22K | -4.82% |
| Sep 30, 2025 | STATE STREET CORP | 3.13% | 2.55M | 55.12M | 740 | +0.03% |
| Sep 30, 2025 | PRICE T ROWE ASSOCIATES INC /MD/ | 2.96% | 2.42M | 52.18M | -477.16K | -16.48% |
| Sep 30, 2025 | FAIRMOUNT FUNDS MANAGEMENT LLC | 4.24% | 3.46M | 74.66M | 0 | 0 |
| Sep 30, 2025 | IKARIAN CAPITAL, LLC | 0.3% | 245.52K | 5.3M | -224.43K | -47.76% |
| Sep 30, 2025 | BANK OF AMERICA CORP /DE/ | 0.3% | 245.76K | 5.3M | 14.92K | +6.46% |
| Sep 30, 2025 | AFFINITY ASSET ADVISORS, LLC | 0.31% | 250K | 5.4M | -140K | -35.90% |
| Sep 30, 2025 | SILVERARC CAPITAL MANAGEMENT, LLC | 0.32% | 259.51K | 5.6M | 259.51K | +100.00% |
| Sep 30, 2025 | JPMORGAN CHASE & CO | 0.38% | 309.13K | 6.67M | -106.86K | -25.69% |
| Sep 30, 2025 | RAYMOND JAMES FINANCIAL INC | 0.38% | 312.76K | 6.75M | -19.33K | -5.82% |
| Sep 30, 2025 | DRIEHAUS CAPITAL MANAGEMENT LLC | 0.42% | 344.08K | 7.43M | -32.76K | -8.69% |
| Sep 30, 2025 | ROYAL BANK OF CANADA | 0.45% | 368.6K | 7.96M | 22.7K | +6.56% |
| Sep 30, 2025 | PANAGORA ASSET MANAGEMENT INC | 0.46% | 377.71K | 8.15M | 25.86K | +7.35% |
| Sep 30, 2025 | NATIONALE-NEDERLANDEN POWSZECHNE TOWARZYSTWO EMERYTALNE S.A. | 0.52% | 423.27K | 9.13M | 0 | 0 |
| Sep 30, 2025 | VICTORY CAPITAL MANAGEMENT INC | 0.53% | 432.42K | 9.33M | -132.37K | -23.44% |
| Sep 30, 2025 | UBS GROUP AG | 0.55% | 447.68K | 9.66M | -85.97K | -16.11% |
| Sep 30, 2025 | HIGHVISTA STRATEGIES LLC | 0.58% | 469.34K | 10.13M | -15.22K | -3.14% |
| Sep 30, 2025 | YIHENG CAPITAL MANAGEMENT, L.P. | 0.61% | 500.26K | 10.8M | 0 | 0 |
| Sep 30, 2025 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.73% | 595.36K | 12.85M | 21.34K | +3.72% |
| Sep 30, 2025 | ROSALIND ADVISORS, INC. | 0.74% | 600K | 12.95M | -100K | -14.29% |
| Sep 30, 2025 | NORTHERN TRUST CORP | 0.76% | 620.86K | 13.4M | 23.98K | +4.02% |
| Sep 30, 2025 | DIMENSIONAL FUND ADVISORS LP | 0.78% | 638.78K | 13.79M | 153.08K | +31.52% |
| Sep 30, 2025 | 5AM VENTURE MANAGEMENT, LLC | 0.9% | 736.6K | 15.9M | 0 | 0 |
| Sep 30, 2025 | GOLDMAN SACHS GROUP INC | 0.94% | 764.56K | 16.5M | -135.26K | -15.03% |
| Sep 30, 2025 | WOODLINE PARTNERS LP | 1% | 815.49K | 17.6M | 0 | 0 |
| Sep 30, 2025 | RICE HALL JAMES & ASSOCIATES, LLC | 1.04% | 851.66K | 18.38M | 336.04K | +65.17% |
| Sep 30, 2025 | CANDRIAM S.C.A. | 1.05% | 860.23K | 18.56M | -2.04K | -0.24% |
| Sep 30, 2025 | MARSHALL WACE, LLP | 1.07% | 869.19K | 18.76M | -338.68K | -28.04% |
| Sep 30, 2025 | DEUTSCHE BANK AG\ | 1.15% | 937.47K | 20.23M | 550.53K | +142.28% |
| Sep 30, 2025 | VIVO CAPITAL, LLC | 1.2% | 982.58K | 21.2M | 0 | 0 |
| Sep 30, 2025 | PICTET ASSET MANAGEMENT HOLDING SA | 1.29% | 1.05M | 22.65M | -216.37K | -17.09% |
| Sep 30, 2025 | WELLINGTON MANAGEMENT GROUP LLP | 1.38% | 1.12M | 24.22M | 851.99K | +314.92% |
| Sep 30, 2025 | PARKMAN HEALTHCARE PARTNERS LLC | 1.41% | 1.15M | 24.91M | -144.34K | -11.11% |
| Sep 30, 2025 | FISHER ASSET MANAGEMENT, LLC | 1.47% | 1.2M | 25.92M | 691.27K | +135.55% |
| Sep 30, 2025 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.5% | 1.22M | 26.33M | 111.54K | +10.06% |
| Sep 30, 2025 | PERCEPTIVE ADVISORS LLC | 1.79% | 1.46M | 31.56M | 1.01M | +226.79% |
| Sep 30, 2025 | LOOMIS SAYLES & CO L P | 1.9% | 1.55M | 33.46M | 211.86K | +15.83% |
| Sep 30, 2025 | BAKER BROS. ADVISORS LP | 2.14% | 1.74M | 37.64M | 0 | 0 |
| Sep 30, 2025 | GEODE CAPITAL MANAGEMENT, LLC | 2.16% | 1.77M | 38.12M | 25.57K | +1.47% |
| Sep 30, 2025 | ALLIANCEBERNSTEIN L.P. | 2.28% | 1.86M | 40.13M | -84.56K | -4.35% |
| Sep 30, 2025 | EVERSEPT PARTNERS, LP | 2.36% | 1.92M | 41.53M | 21.77K | +1.14% |
| Sep 30, 2025 | VR ADVISER, LLC | 4.76% | 3.88M | 83.79M | 0 | 0 |
| Sep 30, 2025 | VANGUARD GROUP INC | 5.31% | 4.33M | 93.48M | -176.53K | -3.92% |
| Sep 30, 2025 | KYNAM CAPITAL MANAGEMENT, LP | 5.43% | 4.43M | 95.55M | 0 | 0 |
| Jun 30, 2025 | NORTHERN TRUST CORP | 0.73% | 596.88K | 8.34M | -105.63K | -15.04% |
| Jun 30, 2025 | CITADEL ADVISORS LLC | 0.8% | 649.54K | 9.08M | 561K | +633.56% |
| Jun 30, 2025 | ROSALIND ADVISORS, INC. | 0.86% | 700K | 9.79M | 105K | +17.65% |
| Jun 30, 2025 | WOODLINE PARTNERS LP | 1% | 815.49K | 11.4M | 1.84K | +0.23% |
| Jun 30, 2025 | CANDRIAM S.C.A. | 1.06% | 862.27K | 12.06M | -18.16K | -2.06% |
| Jun 30, 2025 | DEUTSCHE BANK AG\ | 0.47% | 386.94K | 5.41M | -9.87K | -2.49% |
| Jun 30, 2025 | AFFINITY ASSET ADVISORS, LLC | 0.48% | 390K | 5.45M | 0 | 0 |
| Jun 30, 2025 | BAKER BROS. ADVISORS LP | 2.14% | 1.74M | 24.39M | 1.74M | +100.00% |
| Jun 30, 2025 | GOLDMAN SACHS GROUP INC | 1.1% | 899.83K | 12.58M | -331.27K | -26.91% |
| Jun 30, 2025 | VIVO CAPITAL, LLC | 1.2% | 982.58K | 13.74M | 0 | 0 |
| Jun 30, 2025 | PICTET ASSET MANAGEMENT HOLDING SA | 1.55% | 1.27M | 17.7M | 17.03K | +1.36% |
| Jun 30, 2025 | PARKMAN HEALTHCARE PARTNERS LLC | 1.59% | 1.3M | 18.16M | 234.32K | +22.01% |
| Jun 30, 2025 | EVERSEPT PARTNERS, LP | 2.33% | 1.9M | 26.6M | 524.87K | +38.10% |
| Jun 30, 2025 | ALLIANCEBERNSTEIN L.P. | 2.38% | 1.94M | 27.18M | -77.6K | -3.84% |
| Jun 30, 2025 | MAVERICK CAPITAL LTD | 2.77% | 2.26M | 31.55M | 195.74K | +9.50% |
| Jun 30, 2025 | NOVO HOLDINGS A/S | 2.92% | 2.38M | 33.27M | 129.7K | +5.76% |
| Jun 30, 2025 | STATE STREET CORP | 3.13% | 2.55M | 35.7M | -312.07K | -10.89% |
| Jun 30, 2025 | PARADIGM BIOCAPITAL ADVISORS LP | 3.36% | 2.74M | 38.33M | 646.5K | +30.86% |
| Jun 30, 2025 | PRICE T ROWE ASSOCIATES INC /MD/ | 3.55% | 2.9M | 40.48M | 1.21M | +71.51% |
| Jun 30, 2025 | WELLINGTON MANAGEMENT GROUP LLP | 0.33% | 270.54K | 3.78M | 21.37K | +8.58% |
| Jun 30, 2025 | RAYMOND JAMES FINANCIAL INC | 0.41% | 332.09K | 4.64M | 13.85K | +4.35% |
| Jun 30, 2025 | PANAGORA ASSET MANAGEMENT INC | 0.43% | 351.85K | 4.92M | -2.89K | -0.81% |
| Jun 30, 2025 | FAIRMOUNT FUNDS MANAGEMENT LLC | 4.24% | 3.46M | 48.37M | 14.1K | +0.41% |
| Jun 30, 2025 | VR ADVISER, LLC | 4.76% | 3.88M | 54.28M | 0 | 0 |
| Jun 30, 2025 | KYNAM CAPITAL MANAGEMENT, LP | 5.43% | 4.43M | 61.9M | -272.07K | -5.79% |
| Jun 30, 2025 | VANGUARD GROUP INC | 5.53% | 4.51M | 63.03M | -54.59K | -1.20% |
| Jun 30, 2025 | COMMODORE CAPITAL LP | 5.97% | 4.88M | 68.15M | 1.28M | +35.42% |
| Jun 30, 2025 | LOOMIS SAYLES & CO L P | 1.64% | 1.34M | 18.71M | -31.88K | -2.33% |
| Jun 30, 2025 | TANG CAPITAL MANAGEMENT LLC | 3.48% | 2.84M | 39.74M | 50K | +1.79% |
| Jun 30, 2025 | DEEP TRACK CAPITAL, LP | 6.59% | 5.38M | 75.22M | 0 | 0 |
| Jun 30, 2025 | BLACKROCK, INC. | 6.77% | 5.52M | 77.18M | -187.08K | -3.28% |
| Jun 30, 2025 | FMR LLC | 15% | 12.24M | 171.1M | 15.82K | +0.13% |
| Jun 30, 2025 | DRIEHAUS CAPITAL MANAGEMENT LLC | 0.46% | 376.85K | 5.27M | -893.64K | -70.34% |
| Jun 30, 2025 | JPMORGAN CHASE & CO | 0.51% | 415.99K | 5.82M | 117.44K | +39.34% |
| Jun 30, 2025 | NATIONALE-NEDERLANDEN POWSZECHNE TOWARZYSTWO EMERYTALNE S.A. | 0.52% | 423.27K | 5.92M | 0 | 0 |
| Jun 30, 2025 | FISHER ASSET MANAGEMENT, LLC | 0.63% | 509.96K | 7.13M | -27.07K | -5.04% |
| Jun 30, 2025 | RICE HALL JAMES & ASSOCIATES, LLC | 0.63% | 515.62K | 7.21M | 152.73K | +42.09% |
| Jun 30, 2025 | 5AM VENTURE MANAGEMENT, LLC | 0.9% | 736.6K | 10.3M | 0 | 0 |
| Jun 30, 2025 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.36% | 1.11M | 15.5M | -6K | -0.54% |
| Jun 30, 2025 | MARSHALL WACE, LLP | 1.48% | 1.21M | 16.89M | 123.83K | +11.42% |
| Jun 30, 2025 | GEODE CAPITAL MANAGEMENT, LLC | 2.13% | 1.74M | 24.34M | 20.09K | +1.17% |
| Jun 30, 2025 | ROYAL BANK OF CANADA | 0.42% | 345.9K | 4.84M | 345.69K | +162,293.43% |
| Jun 30, 2025 | PERCEPTIVE ADVISORS LLC | 0.55% | 447.51K | 6.26M | -212.16K | -32.16% |
| Jun 30, 2025 | IKARIAN CAPITAL, LLC | 0.58% | 469.95K | 6.57M | -25K | -5.05% |
| Jun 30, 2025 | HIGHVISTA STRATEGIES LLC | 0.59% | 484.56K | 6.77M | 304.01K | +168.38% |
| Jun 30, 2025 | DIMENSIONAL FUND ADVISORS LP | 0.6% | 485.7K | 6.79M | 485.7K | +100.00% |
| Jun 30, 2025 | YIHENG CAPITAL MANAGEMENT, L.P. | 0.61% | 500.26K | 6.99M | 0 | 0 |
| Jun 30, 2025 | UBS GROUP AG | 0.65% | 533.64K | 7.46M | 29.46K | +5.84% |
| Jun 30, 2025 | VICTORY CAPITAL MANAGEMENT INC | 0.69% | 564.79K | 7.9M | 11.94K | +2.16% |
| Jun 30, 2025 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.7% | 574.02K | 8.02M | 8.06K | +1.42% |
| Mar 31, 2025 | MARSHALL WACE, LLP | 1.33% | 1.08M | 14.61M | 1.08M | +100.00% |
| Mar 31, 2025 | WOODLINE PARTNERS LP | 1% | 813.65K | 10.97M | 0 | 0 |
| Mar 31, 2025 | DEEP TRACK CAPITAL, LP | 6.61% | 5.38M | 72.53M | 857.71K | +18.96% |
| Mar 31, 2025 | PARKMAN HEALTHCARE PARTNERS LLC | 1.31% | 1.06M | 14.35M | -23.13K | -2.13% |
| Mar 31, 2025 | BLACKROCK, INC. | 7.02% | 5.71M | 76.95M | -50.47K | -0.88% |
| Mar 31, 2025 | MAVERICK CAPITAL LTD | 2.53% | 2.06M | 27.79M | 7.37K | +0.36% |
| Mar 31, 2025 | ALLIANCEBERNSTEIN L.P. | 2.49% | 2.02M | 27.25M | -265.38K | -11.60% |
| Mar 31, 2025 | LOOMIS SAYLES & CO L P | 1.68% | 1.37M | 18.47M | -30.03K | -2.14% |
| Mar 31, 2025 | YIHENG CAPITAL MANAGEMENT, L.P. | 0.62% | 500.26K | 6.74M | -250K | -33.32% |
| Mar 31, 2025 | IKARIAN CAPITAL, LLC | 0.61% | 494.95K | 6.67M | 25K | +5.32% |
| Mar 31, 2025 | OCTAGON CAPITAL ADVISORS LP | 0.55% | 450K | 6.07M | -420K | -48.28% |
| Mar 31, 2025 | NATIONALE-NEDERLANDEN POWSZECHNE TOWARZYSTWO EMERYTALNE S.A. | 0.52% | 423.27K | 5.71M | 0 | 0 |
| Mar 31, 2025 | DEUTSCHE BANK AG\ | 0.49% | 396.81K | 5.35M | -6.07K | -1.51% |
| Mar 31, 2025 | DRIEHAUS CAPITAL MANAGEMENT LLC | 1.56% | 1.27M | 17.13M | -605.4K | -32.27% |
| Mar 31, 2025 | NORTHERN TRUST CORP | 0.86% | 702.52K | 9.47M | 8.38K | +1.21% |
| Mar 31, 2025 | FISHER ASSET MANAGEMENT, LLC | 0.66% | 537.02K | 7.24M | 19K | +3.67% |
| Mar 31, 2025 | UBS GROUP AG | 0.62% | 504.19K | 6.8M | -7.89K | -1.54% |
| Mar 31, 2025 | GEODE CAPITAL MANAGEMENT, LLC | 2.12% | 1.72M | 23.2M | 61.55K | +3.71% |
| Mar 31, 2025 | EVERSEPT PARTNERS, LP | 1.69% | 1.38M | 18.57M | 597.68K | +76.63% |
| Mar 31, 2025 | PRICE T ROWE ASSOCIATES INC /MD/ | 2.08% | 1.69M | 22.76M | 361.32K | +27.23% |
| Mar 31, 2025 | PICTET ASSET MANAGEMENT HOLDING SA | 1.54% | 1.25M | 16.83M | 0 | 0 |
| Mar 31, 2025 | VIVO CAPITAL, LLC | 1.21% | 982.58K | 13.25M | 0 | 0 |
| Mar 31, 2025 | CANDRIAM S.C.A. | 1.08% | 880.43K | 11.87M | 149.21K | +20.41% |
| Mar 31, 2025 | GREAT POINT PARTNERS LLC | 0.92% | 750K | 10.11M | 0 | 0 |
| Mar 31, 2025 | WELLINGTON MANAGEMENT GROUP LLP | 0.31% | 249.17K | 3.36M | 24.69K | +11.00% |
| Mar 31, 2025 | | 0.31% | 248.63K | 3.35M | 248.63K | +100.00% |
| Mar 31, 2025 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.37% | 1.11M | 15.02M | -555.41K | -33.26% |
| Mar 31, 2025 | VR ADVISER, LLC | 4.77% | 3.88M | 52.34M | 0 | 0 |
| Mar 31, 2025 | COMMODORE CAPITAL LP | 4.43% | 3.6M | 48.53M | 1.2M | +50.00% |
| Mar 31, 2025 | STATE STREET CORP | 3.52% | 2.87M | 38.63M | -657.07K | -18.65% |
| Mar 31, 2025 | TANG CAPITAL MANAGEMENT LLC | 3.43% | 2.79M | 37.65M | 300K | +12.03% |
| Mar 31, 2025 | NOVO HOLDINGS A/S | 2.77% | 2.25M | 30.33M | 300 | +0.01% |
| Mar 31, 2025 | PARADIGM BIOCAPITAL ADVISORS LP | 2.58% | 2.1M | 28.24M | 275K | +15.11% |
| Mar 31, 2025 | GOLDMAN SACHS GROUP INC | 1.51% | 1.23M | 16.6M | 311K | +33.80% |
| Mar 31, 2025 | RICE HALL JAMES & ASSOCIATES, LLC | 0.45% | 362.89K | 4.89M | 309.52K | +579.89% |
| Mar 31, 2025 | MILLENNIUM MANAGEMENT LLC | 0.37% | 297.97K | 4.02M | -68.01K | -18.58% |
| Mar 31, 2025 | PERCEPTIVE ADVISORS LLC | 0.81% | 659.66K | 8.89M | -826.85K | -55.62% |
| Mar 31, 2025 | ROSALIND ADVISORS, INC. | 0.73% | 595K | 8.02M | 595K | +100.00% |
| Mar 31, 2025 | PANAGORA ASSET MANAGEMENT INC | 0.44% | 354.74K | 4.78M | 101.72K | +40.20% |
| Mar 31, 2025 | VICTORY CAPITAL MANAGEMENT INC | 0.68% | 552.85K | 7.45M | 142.41K | +34.70% |
| Mar 31, 2025 | KYNAM CAPITAL MANAGEMENT, LP | 5.78% | 4.7M | 63.36M | 1.37M | +41.30% |
| Mar 31, 2025 | VANGUARD GROUP INC | 5.61% | 4.56M | 61.51M | -31.95K | -0.70% |
| Mar 31, 2025 | TWO SIGMA INVESTMENTS, LP | 0.27% | 222.4K | 3M | -202.14K | -47.61% |
| Mar 31, 2025 | MORGAN STANLEY | 0.42% | 341.8K | 4.61M | -397.35K | -53.76% |
| Mar 31, 2025 | FMR LLC | 15.03% | 12.22M | 164.77M | 341.07K | +2.87% |
| Mar 31, 2025 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.7% | 565.96K | 7.63M | -9.11K | -1.58% |
| Mar 31, 2025 | RENAISSANCE TECHNOLOGIES LLC | 0.39% | 320.3K | 4.32M | -50.9K | -13.71% |
| Mar 31, 2025 | RAYMOND JAMES FINANCIAL INC | 0.39% | 318.24K | 4.29M | 4.45K | +1.42% |
| Mar 31, 2025 | JPMORGAN CHASE & CO | 0.37% | 298.55K | 4.02M | -5.78K | -1.90% |
| Mar 31, 2025 | AFFINITY ASSET ADVISORS, LLC | 0.48% | 390K | 5.26M | 230.39K | +144.34% |
| Mar 31, 2024 | FMR LLC | 21.04% | 9.42M | 164.86M | 1.79M | +23.47% |
| Mar 31, 2024 | KOPP FAMILY OFFICE, LLC | 0.46% | 205.64K | 3.6M | 40 | +0.02% |
| Mar 31, 2024 | KOPP LEROY C | 0.46% | 205.64K | 3.6M | 205.64K | +100.00% |
| Mar 31, 2024 | TWO SIGMA INVESTMENTS, LP | 0.51% | 226.85K | 3.97M | 226.85K | +100.00% |
| Mar 31, 2024 | WELLINGTON MANAGEMENT GROUP LLP | 0.54% | 240.83K | 4.22M | 48.73K | +25.37% |
| Mar 31, 2024 | RENAISSANCE TECHNOLOGIES LLC | 0.58% | 261.7K | 4.58M | 248.3K | +1,852.99% |
| Mar 31, 2024 | CUTTER CAPITAL MANAGEMENT, LP | 0.62% | 278.64K | 4.88M | -29.08K | -9.45% |
| Mar 31, 2024 | ROSALIND ADVISORS, INC. | 0.67% | 300K | 5.25M | -60.33K | -16.74% |
| Mar 31, 2024 | TWO SIGMA ADVISERS, LP | 0.68% | 304.4K | 5.33M | 204.1K | +203.49% |
| Mar 31, 2024 | RUSSELL INVESTMENTS GROUP, LTD. | 0.72% | 321.61K | 5.63M | -7.88K | -2.39% |
| Mar 31, 2024 | SOLEUS CAPITAL MANAGEMENT, L.P. | 0.76% | 340K | 5.95M | 202K | +146.38% |
| Mar 31, 2024 | CITIGROUP INC | 0.78% | 347.91K | 6.09M | 263.63K | +312.77% |
| Mar 31, 2024 | UBS GROUP AG | 0.85% | 379.58K | 6.65M | 236.2K | +164.73% |
| Mar 31, 2024 | RAFFERTY ASSET MANAGEMENT, LLC | 0.91% | 408.89K | 7.16M | 206.4K | +101.93% |
| Mar 31, 2024 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.95% | 424.09K | 7.43M | 52.77K | +14.21% |
| Mar 31, 2024 | EAGLE ASSET MANAGEMENT INC | 0.98% | 438.77K | 7.57M | -14.54K | -3.21% |
| Mar 31, 2024 | WOODLINE PARTNERS LP | 0.98% | 438.92K | 7.69M | 438.92K | +100.00% |
| Mar 31, 2024 | GOLDMAN SACHS GROUP INC | 1.21% | 543.14K | 9.51M | 161.4K | +42.28% |
| Mar 31, 2024 | MORGAN STANLEY | 1.26% | 562.54K | 9.85M | 37.64K | +7.17% |
| Mar 31, 2024 | RTW INVESTMENTS, LP | 1.35% | 605.82K | 10.61M | 0 | 0 |
| Mar 31, 2024 | BIOIMPACT CAPITAL LLC | 1.37% | 614.01K | 10.75M | 514.01K | +514.01% |
| Mar 31, 2024 | OCTAGON CAPITAL ADVISORS LP | 1.39% | 620K | 10.86M | 0 | 0 |
| Mar 31, 2024 | GHOST TREE CAPITAL, LLC | 1.4% | 625K | 10.94M | 325K | +108.33% |
| Mar 31, 2024 | TANG CAPITAL MANAGEMENT LLC | 1.55% | 692.93K | 12.13M | 0 | 0 |
| Mar 31, 2024 | LOGOS GLOBAL MANAGEMENT LP | 1.56% | 700K | 12.26M | 100K | +16.67% |
| Mar 31, 2024 | 5AM VENTURE MANAGEMENT, LLC | 1.65% | 736.6K | 12.9M | 150K | +25.57% |
| Mar 31, 2024 | POLAR CAPITAL HOLDINGS PLC | 1.99% | 889.2K | 15.57M | -90.72K | -9.26% |
| Mar 31, 2024 | YIHENG CAPITAL MANAGEMENT, L.P. | 2.12% | 948.13K | 16.6M | -280.4K | -22.82% |
| Mar 31, 2024 | FISHER ASSET MANAGEMENT, LLC | 0.87% | 389.09K | 6.81M | 389.09K | +100.00% |
| Mar 31, 2024 | CITADEL ADVISORS LLC | 1.7% | 762.41K | 13.35M | -124.23K | -14.01% |
| Mar 31, 2024 | PICTET ASSET MANAGEMENT HOLDING SA | 2.45% | 1.1M | 19.18M | 44.57K | +4.24% |
| Mar 31, 2024 | NOVO HOLDINGS A/S | 2.46% | 1.1M | 19.26M | 1.1M | +100.00% |
| Mar 31, 2024 | VR ADVISER, LLC | 8.68% | 3.88M | 67.99M | 48 | 0.00% |
| Mar 31, 2024 | STATE STREET CORP | 10.03% | 4.49M | 78.6M | 1.78M | +65.73% |
| Mar 31, 2024 | DIMENSIONAL FUND ADVISORS LP | 0.02% | 10.07K | 176.33K | 0 | 0 |
| Mar 31, 2024 | ARIZONA STATE RETIREMENT SYSTEM | 0.03% | 11.49K | 201.19K | 1.96K | +20.53% |
| Mar 31, 2024 | RAYMOND JAMES & ASSOCIATES | 0.03% | 11.55K | 202.22K | 1.32K | +12.92% |
| Mar 31, 2024 | PRINCIPAL FINANCIAL GROUP INC | 0.03% | 11.92K | 208.63K | 1.06K | +9.74% |
| Mar 31, 2024 | NEW YORK STATE COMMON RETIREMENT FUND | 0.04% | 17.95K | 314K | 451 | +2.58% |
| Mar 31, 2024 | INVESCO LTD. | 0.04% | 18.73K | 327.96K | -126.04K | -87.06% |
| Mar 31, 2024 | E FUND MANAGEMENT CO., LTD. | 0.04% | 19.32K | 338.35K | 8.45K | +77.68% |
| Mar 31, 2024 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0.05% | 21.2K | 371.21K | 21.2K | +100.00% |
| Mar 31, 2024 | STATE OF WISCONSIN INVESTMENT BOARD | 0.05% | 22.27K | 389.95K | -36.06K | -61.82% |
| Mar 31, 2024 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0.05% | 24.24K | 424.39K | 8.18K | +50.96% |
| Mar 31, 2024 | AMERICAN INTERNATIONAL GROUP, INC. | 0.05% | 24.52K | 429.26K | 3.27K | +15.37% |
| Mar 31, 2024 | METLIFE INVESTMENT MANAGEMENT, LLC | 0.06% | 25.57K | 447.73K | 3.3K | +14.81% |
| Mar 31, 2024 | STONECREST WEALTH MANAGEMENT, INC. | 0.06% | 27.68K | 484.59K | -116 | -0.42% |
| Mar 31, 2024 | LIGHTHOUSE INVESTMENT PARTNERS, LLC | 0.06% | 28.41K | 497.39K | 28.41K | +100.00% |
| Mar 31, 2024 | MIRAE ASSET GLOBAL INVESTMENTS CO., LTD. | 0.06% | 28.82K | 628.68K | 1.14K | +4.10% |
| Mar 31, 2024 | WELLS FARGO & COMPANY/MN | 0.07% | 32.13K | 562.56K | 6.24K | +24.08% |
| Mar 31, 2024 | ALGERT GLOBAL LLC | 0.08% | 37.82K | 662K | 37.82K | +100.00% |
| Mar 31, 2024 | LEGAL & GENERAL GROUP PLC | 0.09% | 39.09K | 684.41M | 4.52K | +13.08% |
| Mar 31, 2024 | ALPS ADVISORS INC | 0.1% | 44.28K | 775.27K | 9.42K | +27.03% |
| Mar 31, 2024 | CREDIT SUISSE AG/ | 0.11% | 47.88K | 838.33K | 6.81K | +16.59% |
| Mar 31, 2024 | JPMORGAN CHASE & CO | 0.11% | 49.02K | 858.39K | -7.92K | -13.90% |
| Mar 31, 2024 | PROFUND ADVISORS LLC | 0.14% | 63.01K | 1.1B | 30.02K | +90.99% |
| Mar 31, 2024 | RHUMBLINE ADVISERS | 0.15% | 67.52K | 1.18M | 7.09K | +11.73% |
| Mar 31, 2024 | KNIGHTS OF COLUMBUS ASSET ADVISORS LLC | 0.18% | 78.82K | 1.38M | -75.13K | -48.80% |
| Mar 31, 2024 | SWISS NATIONAL BANK | 0.19% | 82.9K | 1.45M | 15.7K | +23.36% |
| Mar 31, 2024 | HENNION & WALSH ASSET MANAGEMENT, INC. | 0.25% | 109.82K | 1.92M | 34.04K | +44.92% |
| Mar 31, 2024 | EVERSEPT PARTNERS, LP | 0.32% | 142.08K | 2.49M | 4.73K | +3.45% |
| Mar 31, 2024 | BANK OF NEW YORK MELLON CORP | 0.34% | 151.86K | 2.66M | 2.05K | +1.37% |
| Mar 31, 2024 | CANDRIAM S.C.A. | 0.63% | 280K | 4.9M | 280K | +100.00% |
| Mar 31, 2024 | GEODE CAPITAL MANAGEMENT, LLC | 2.6% | 1.16M | 20.39M | 169.8K | +17.07% |
| Mar 31, 2024 | NUVEEN ASSET MANAGEMENT, LLC | 2.98% | 1.33M | 23.33M | 1.1M | +469.72% |
| Mar 31, 2024 | GREAT POINT PARTNERS LLC | 2.98% | 1.34M | 23.38M | 1.34M | +100.00% |
| Mar 31, 2024 | VIVO CAPITAL, LLC | 3.75% | 1.68M | 29.39M | 0 | 0 |
| Mar 31, 2024 | FAIRMOUNT FUNDS MANAGEMENT LLC | 4.12% | 1.85M | 32.32M | 476.19K | +34.77% |
| Mar 31, 2024 | COMMODORE CAPITAL LP | 4.32% | 1.93M | 33.88M | 10.58K | +0.55% |
| Mar 31, 2024 | MAVERICK CAPITAL LTD | 6.02% | 2.69M | 47.14M | 366.57K | +15.76% |
| Mar 31, 2024 | DEEP TRACK CAPITAL, LP | 7.72% | 3.46M | 60.52M | -175.68K | -4.84% |
| Mar 31, 2024 | PERCEPTIVE ADVISORS LLC | 8.17% | 3.66M | 64.04M | 1.93M | +111.37% |
| Mar 31, 2024 | PARADIGM BIOCAPITAL ADVISORS LP | 11.24% | 5.03M | 88.1M | 236.93K | +4.94% |
| Mar 31, 2024 | NORTHERN TRUST CORP | 1.03% | 462.68K | 8.1M | 49.04K | +11.86% |
| Mar 31, 2024 | BANK OF AMERICA CORP /DE/ | 1.06% | 475.73K | 8.33M | 189.29K | +66.08% |
| Mar 31, 2024 | ALLIANCEBERNSTEIN L.P. | 3.85% | 1.72M | 30.17M | -336.65K | -16.35% |
| Mar 31, 2024 | VANGUARD GROUP INC | 7.23% | 3.23M | 56.63M | 233.33K | +7.78% |
| Mar 31, 2024 | BLACKROCK INC. | 8.52% | 3.81M | 66.76M | 386.18K | +11.27% |
| Dec 31, 2023 | STATE STREET CORP | 6.2% | 2.71M | 58.99M | -233.31K | -7.93% |
| Dec 31, 2023 | COMMODORE CAPITAL LP | 4.41% | 1.92M | 41.91M | -275.93K | -12.54% |
| Dec 31, 2023 | KNIGHTS OF COLUMBUS ASSET ADVISORS LLC | 0.35% | 153.95K | 3.35M | 124.4K | +420.93% |
| Dec 31, 2023 | POLAR ASSET MANAGEMENT PARTNERS INC. | 0.37% | 159.7K | 3.48M | 83.1K | +108.49% |
| Dec 31, 2023 | SCHONFELD STRATEGIC ADVISORS LLC | 0.41% | 178.92K | 3.9M | 70.88K | +65.61% |
| Dec 31, 2023 | WELLINGTON MANAGEMENT GROUP LLP | 0.44% | 192.1K | 4.18M | 192.1K | +100.00% |
| Dec 31, 2023 | HIGHVISTA STRATEGIES LLC | 0.45% | 198.48K | 4.32M | 93.73K | +89.47% |
| Dec 31, 2023 | RAFFERTY ASSET MANAGEMENT, LLC | 0.46% | 202.49K | 4.41M | -59.81K | -22.80% |
| Dec 31, 2023 | KOPP FAMILY OFFICE, LLC | 0.47% | 205.6K | 4.48M | -8.69K | -4.06% |
| Dec 31, 2023 | BARCLAYS PLC | 0.5% | 219.59K | 4.78M | 88.04K | +66.92% |
| Dec 31, 2023 | MILLENNIUM MANAGEMENT LLC | 0.51% | 224.79K | 4.9M | -1.16M | -83.72% |
| Dec 31, 2023 | NUVEEN ASSET MANAGEMENT, LLC | 0.54% | 233.88K | 5.09M | 30.44K | +14.96% |
| Dec 31, 2023 | WALLEYE CAPITAL LLC | 0.55% | 241.41K | 5.26M | 227.88K | +1,684.26% |
| Dec 31, 2023 | ACUTA CAPITAL PARTNERS, LLC | 0.64% | 281.5K | 6.13M | 57.16K | +25.48% |
| Dec 31, 2023 | BANK OF AMERICA CORP /DE/ | 0.66% | 286.45K | 6.24M | 81.23K | +39.58% |
| Dec 31, 2023 | GHOST TREE CAPITAL, LLC | 0.69% | 300K | 6.53M | 25K | +9.09% |
| Dec 31, 2023 | MARSHALL WACE, LLP | 0.69% | 301.29K | 6.56M | -661.2K | -68.70% |
| Dec 31, 2023 | BRAIDWELL LP | 0.74% | 323.1K | 7.04M | -1.41M | -81.38% |
| Dec 31, 2023 | RUSSELL INVESTMENTS GROUP, LTD. | 0.75% | 329.48K | 7.18M | 30.34K | +10.14% |
| Dec 31, 2023 | ROSALIND ADVISORS, INC. | 0.83% | 360.33K | 7.85M | 360.33K | +100.00% |
| Dec 31, 2023 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.85% | 371.31K | 8.09M | 58.09K | +18.55% |
| Dec 31, 2023 | VANGUARD GROUP INC | 6.87% | 3M | 65.36M | 552.93K | +22.59% |
| Dec 31, 2023 | BLACKROCK INC. | 7.85% | 3.43M | 74.63M | 433.39K | +14.48% |
| Dec 31, 2023 | DEEP TRACK CAPITAL, LP | 8.32% | 3.63M | 79.1M | 668.46K | +22.56% |
| Dec 31, 2023 | VR ADVISER, LLC | 8.89% | 3.88M | 84.56M | 800K | +25.95% |
| Dec 31, 2023 | PARADIGM BIOCAPITAL ADVISORS LP | 10.98% | 4.79M | 104.42M | 1.11M | +30.22% |
| Dec 31, 2023 | FMR LLC | 17.47% | 7.63M | 166.08M | 7.36M | +2,808.43% |
| Dec 31, 2023 | GOLDMAN SACHS GROUP INC | 0.87% | 381.74K | 8.31M | -17.54K | -4.39% |
| Dec 31, 2023 | NORTHERN TRUST CORP | 0.95% | 413.64K | 9.01M | 11.98K | +2.98% |
| Dec 31, 2023 | EAGLE ASSET MANAGEMENT INC | 1.04% | 453.31K | 9.87M | -5.86K | -1.28% |
| Dec 31, 2023 | MORGAN STANLEY | 1.2% | 524.9K | 11.43M | 191.18K | +57.29% |
| Dec 31, 2023 | JEFFERIES FINANCIAL GROUP INC. | 1.24% | 540.67K | 11.78M | 540.67K | +100.00% |
| Dec 31, 2023 | 5AM VENTURE MANAGEMENT, LLC | 1.34% | 586.6K | 12.78M | 176.6K | +43.07% |
| Dec 31, 2023 | LOGOS GLOBAL MANAGEMENT LP | 1.37% | 600K | 13.07M | -450K | -42.86% |
| Dec 31, 2023 | RTW INVESTMENTS, LP | 1.39% | 605.82K | 13.19M | 605.82K | +100.00% |
| Dec 31, 2023 | KYNAM CAPITAL MANAGEMENT, LP | 1.39% | 607.92K | 13.24M | -91.77K | -13.12% |
| Dec 31, 2023 | OCTAGON CAPITAL ADVISORS LP | 1.42% | 620K | 13.5M | -447.14K | -41.90% |
| Dec 31, 2023 | TANG CAPITAL MANAGEMENT LLC | 1.59% | 692.93K | 15.09M | 23.8K | +3.56% |
| Dec 31, 2023 | CITADEL ADVISORS LLC | 2.03% | 886.64K | 19.31M | 784.21K | +765.60% |
| Dec 31, 2023 | POLAR CAPITAL HOLDINGS PLC | 2.24% | 979.92K | 21.34M | -620.08K | -38.76% |
| Dec 31, 2023 | GEODE CAPITAL MANAGEMENT, LLC | 2.28% | 994.47K | 21.66M | 135.37K | +15.76% |
| Dec 31, 2023 | | 0.7% | 307.72K | 6.7M | 307.72K | +100.00% |
| Dec 31, 2023 | YIHENG CAPITAL MANAGEMENT, L.P. | 2.81% | 1.23M | 26.76M | 0 | 0 |
| Dec 31, 2023 | FAIRMOUNT FUNDS MANAGEMENT LLC | 3.14% | 1.37M | 29.83M | 0 | 0 |
| Dec 31, 2023 | VIVO CAPITAL, LLC | 3.84% | 1.68M | 36.55M | 0 | 0 |
| Dec 31, 2023 | PERCEPTIVE ADVISORS LLC | 3.96% | 1.73M | 37.68M | 719.01K | +71.10% |
| Dec 31, 2023 | ALLIANCEBERNSTEIN L.P. | 4.72% | 2.06M | 44.86M | 168.47K | +8.91% |
| Dec 31, 2023 | MAVERICK CAPITAL LTD | 5.33% | 2.33M | 50.66M | 2.33M | +100.00% |