How many institutions own VRDN stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own VRDN shares is 253, representing 101.33% of the company's common stock.

Who are the major shareholders selling Viridian Therapeutics, Inc. stock?

HUDSON BAY CAPITAL MANAGEMENT LP, in the last quarter, reduced its stake in VRDN by -13.57% restricting it's holding to 151.46 thousand shares of worth nearly $4.71M. UBS GROUP AG also lessened -63.18% of the VRDN shares from its portfolio, reducing its holding to 164.82 thousand shares of worth $5.13M. KOPP FAMILY OFFICE, LLC also shunned VRDN shares holding by -10.66% last quarter which brought its holding to 173.17 thousand shares worth $5.39M.

Investors who are buying VRDN stock?

As per its latest 13F filing, STATE STREET CORP increased its stake in VRDN by 35.72% in the last quarter. The institutional holder raised its holding to 3.47 million shares having worth more than $107.88M. VANGUARD GROUP INC also added 29.55% more shares of VRDN to its portfolio, raising its holding to 5.61 million shares of worth $174.65M. BLACKROCK, INC. also increased its VRDN shares holding by 18.48% which brought its holding to 6.43 million shares worth $200.16M.

VRDN's major insiders: who are they?

The insider with the most stakes in VRDN is Fairmount Funds Management LLC , at the company. Additionally, VRDN stock is highly held by 10 percent owner Frazier Life Sciences Public Fund, L.P. and Fairmount Healthcare Fund II L.P. among others.

Did an insider recently sell VRDN stock?

Company executives, directors, and other insiders own 0.14% percent of Viridian Therapeutics, Inc.'s stock. Within the last six months, there have been 1 transaction(s) in which VRDN insiders have sold stock, totaling 2.27K shares. Insiders that have sold shares include TOUSIGNANT JENNIFER, MEISNER LARA, and VIOLIN JONATHAN.

Which insider recently purchased VRDN stock?

There have been 1 transaction(s) during the past 6-months in which Viridian Therapeutics, Inc. insiders have bought stock, totalling 454545 shares

How much of VRDN does insiders own?

Around 3.91M Viridian Therapeutics, Inc. shares are held by insiders, which represents about 0.14% of VRDN stock.

Who is the insider with the largest stake?

VRDN , Fairmount Funds Management LLC holds the largest portfolio of the company's shares. VRDN shares owned by Fairmount total nearly 3.91 million.

Which institution holds the most shares in VRDN?

STATE STREET CORP is the largest institutional owner in VRDN which holds 3.47 million shares worth $107.88M or 4.24% of the total VRDN shares outstanding followed by VANGUARD GROUP INC with ownership of 5.61 million shares representing 6.86% of the VRDN ownership. BLACKROCK, INC. is the third largest stakeholder with 6.43 million shares or 7.86% of the ownership worth more than $200.16M.

Is Viridian Therapeutics, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the VRDN is concerned, it is a stock which is optionable.

Is there a short position on VRDN's shares?

Number of VRDN shares short is 11.57M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding VRDN shares are there?

As of today, 81.66M shares of VRDN are outstanding.

Is there many float in VRDN stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, VRDN has 66.94M shares in float.

VRDN short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for VRDN is 13.77.

Viridian Therapeutics (VRDN) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares14.17

Short Percent Of Float14.8

Shares Outstanding81.66M

Shares Float66.94M

Shares Short11.57M

Short Ratio13.77

14.8%

Short % of Float

14.17%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

0.14% Percentage of Shares held by All Insiders

101.33% Percentage of Shares held by All Institutions

101.47% Percentage of Float held by Institutions

253

Number of Institutions Holding Shares

Institutional Ownership

About 101.33% of VRDN shares are held by financial institutions. STATE STREET CORP is the top corporate investor, holding 3.47M shares valued at $107.88M. A 4.24% stake in Viridian Therapeutics, Inc. is owned by the company. VANGUARD GROUP INC owns 5.61M shares valued at $174.65M, which translates its holding of 6.86% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	STATE STREET CORP	4.24%	3.47M	107.88M	912.39K	+35.72%
Dec 31, 2025	VANGUARD GROUP INC	6.86%	5.61M	174.65M	1.28M	+29.55%
Dec 31, 2025	BLACKROCK, INC.	7.86%	6.43M	200.16M	1M	+18.48%
Dec 31, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.19%	151.46K	4.71M	-23.79K	-13.57%
Dec 31, 2025	MACQUARIE MANAGEMENT HOLDINGS, INC.	0.19%	154.74K	4.82B	154.74K	+100.00%
Dec 31, 2025	UBS GROUP AG	0.2%	164.82K	5.13M	-282.86K	-63.18%
Dec 31, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.21%	169.17K	5.26M	14.83K	+9.61%
Dec 31, 2025	KOPP FAMILY OFFICE, LLC	0.21%	173.17K	5.39M	-20.66K	-10.66%
Dec 31, 2025	PRIVIUM FUND MANAGEMENT B.V.	0.21%	173.52K	5.4M	173.52K	+100.00%
Dec 31, 2025	PRINCIPAL FINANCIAL GROUP INC	0.22%	175.93K	5.47M	-37.4K	-17.53%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.26%	215.87K	6.72M	18.7K	+9.48%
Dec 31, 2025	VICTORY CAPITAL MANAGEMENT INC	0.28%	226.82K	7.06M	-205.6K	-47.55%
Dec 31, 2025		1.05%	858.63K	26.72B	858.63K	+100.00%
Dec 31, 2025	JANE STREET GROUP, LLC	0.34%	279.61K	8.7B	244.19K	+689.54%
Dec 31, 2025	RAYMOND JAMES FINANCIAL INC	0.37%	303.77K	9.42M	-8.99K	-2.87%
Dec 31, 2025	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	0.42%	341.26K	10.62M	341.26K	+100.00%
Dec 31, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.43%	348.57K	10.85M	89.06K	+34.32%
Dec 31, 2025	NATIONALE-NEDERLANDEN POWSZECHNE TOWARZYSTWO EMERYTALNE S.A.	0.52%	423.27K	13.17M	0	0
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.63%	517.4K	16.1M	275.09K	+113.53%
Dec 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.68%	555.59K	17.29M	-83.18K	-13.02%
Dec 31, 2025	CITADEL ADVISORS LLC	0.83%	679.69K	21.15M	602.32K	+778.46%
Dec 31, 2025	FIRST TURN MANAGEMENT, LLC	0.84%	690.53K	21.49M	690.53K	+100.00%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.92%	748.96K	23.31M	153.6K	+25.80%
Dec 31, 2025	CANDRIAM S.C.A.	0.96%	785.1K	24.43M	-75.13K	-8.73%
Dec 31, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.96%	788.08K	24.52M	-366.41K	-31.74%
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.14%	116.52K	3.63M	78.88K	+209.57%
Dec 31, 2025	FIRST TRUST ADVISORS LP	0.15%	119.89K	3.73M	119.89K	+100.00%
Dec 31, 2025	NORGES BANK	0.15%	122.79K	3.82M	122.79K	+100.00%
Dec 31, 2025	SWISS NATIONAL BANK	0.16%	128.6K	4M	17.9K	+16.17%
Dec 31, 2025	CENTERBOOK PARTNERS LP	0.17%	136.72K	4.25M	136.72K	+100.00%
Dec 31, 2025	AFFINITY ASSET ADVISORS, LLC	0.31%	250K	7.78M	0	0
Dec 31, 2025	PROPEL BIO MANAGEMENT, LLC	0.35%	282.53K	8.79M	192.53K	+213.92%
Dec 31, 2025	SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)	0.35%	286.32K	8.91M	286.32K	+100.00%
Dec 31, 2025	PANAGORA ASSET MANAGEMENT INC	0.4%	324.75K	10.11M	-52.97K	-14.02%
Dec 31, 2025	FEDERATED HERMES, INC.	0.51%	416.36K	12.96M	416.23K	+315,322.73%
Dec 31, 2025	ROSALIND ADVISORS, INC.	0.55%	450K	14M	-150K	-25.00%
Dec 31, 2025	DEUTSCHE BANK AG\	0.59%	479.76K	14.93M	-457.71K	-48.82%
Dec 31, 2025	NUVEEN, LLC	0.91%	742.34K	23.1M	580.47K	+358.61%
Dec 31, 2025	VIVO CAPITAL, LLC	1.2%	982.58K	30.58M	0	0
Dec 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.13%	922.77K	28.72M	-126.62K	-12.07%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	1.21%	990.12K	30.81M	744.36K	+302.88%
Dec 31, 2025	ALGERT GLOBAL LLC	0.52%	425.04K	13.23M	425.04K	+100.00%
Dec 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.62%	503.87K	15.68M	301.05K	+148.43%
Dec 31, 2025	NORTHERN TRUST CORP	0.82%	668.42K	20.8M	47.56K	+7.66%
Dec 31, 2025	5AM VENTURE MANAGEMENT, LLC	0.9%	736.6K	22.92M	0	0
Dec 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.97%	790.02K	24.59M	-430.11K	-35.25%
Dec 31, 2025	RICE HALL JAMES & ASSOCIATES, LLC	1.08%	884.53K	27.53M	32.87K	+3.86%
Dec 31, 2025	D. E. SHAW & CO., INC.	1.22%	1M	31.14M	1M	+100.00%
Dec 31, 2025	WOODLINE PARTNERS LP	1.36%	1.12M	34.73M	300.44K	+36.84%
Dec 31, 2025	ALLIANCEBERNSTEIN L.P.	1.73%	1.41M	44.01M	-445.28K	-23.95%
Dec 31, 2025	AVORO CAPITAL ADVISORS LLC	1.83%	1.5M	46.68M	1.5M	+100.00%
Dec 31, 2025	EVERSEPT PARTNERS, LP	2.18%	1.78M	55.46M	-142.07K	-7.38%
Dec 31, 2025	TANG CAPITAL MANAGEMENT LLC	2.19%	1.79M	55.79M	-1.05M	-36.94%
Dec 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	2.41%	1.97M	61.35M	848.88K	+75.62%
Dec 31, 2025	BAKER BROS. ADVISORS LP	2.41%	1.97M	61.36M	227.27K	+13.03%
Dec 31, 2025	NOVO HOLDINGS A/S	2.91%	2.38M	74.07M	0	0
Dec 31, 2025	PERCEPTIVE ADVISORS LLC	3.72%	3.04M	94.69M	1.58M	+108.06%
Dec 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	4.21%	3.44M	107.04M	1.02M	+42.24%
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	0.56%	460.13K	14.32M	323.85K	+237.63%
Dec 31, 2025	VR ADVISER, LLC	4.75%	3.88M	120.83M	0	0
Dec 31, 2025	FAIRMOUNT FUNDS MANAGEMENT LLC	4.79%	3.91M	121.82M	454.55K	+13.14%
Dec 31, 2025	BELLEVUE GROUP AG	5.33%	4.36M	135.64M	4.36M	+100.00%
Dec 31, 2025	FMR LLC	17.59%	14.38M	447.64M	2.14M	+17.43%
Dec 31, 2025	PARADIGM BIOCAPITAL ADVISORS LP	1.76%	1.44M	44.91M	-1.17M	-44.70%
Dec 31, 2025	KYNAM CAPITAL MANAGEMENT, LP	1.8%	1.47M	45.76M	-2.96M	-66.79%
Dec 31, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.14%	112.68K	3.5M	29.18K	+34.95%
Dec 31, 2025	TD ASSET MANAGEMENT INC	0.14%	114K	3.55M	35.2K	+44.67%
Dec 31, 2025	JPMORGAN CHASE & CO	1.24%	1.01M	31.44M	701.13K	+226.80%
Dec 31, 2025	JENNISON ASSOCIATES LLC	1.41%	1.15M	35.91M	1.15M	+100.00%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	1.55%	1.26M	39.34M	499.49K	+65.33%
Dec 31, 2025	MARSHALL WACE, LLP	1.68%	1.38M	42.81M	506.55K	+58.28%
Dec 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.17%	139.36K	4.34M	380	+0.27%
Dec 31, 2025	KNOTT DAVID M JR	0.18%	145K	4.51M	28.43K	+24.38%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.18%	147.32K	4.58M	41.44K	+39.13%
Dec 31, 2025	BARCLAYS PLC	0.3%	244.27K	7.6M	36.03K	+17.30%
Dec 31, 2025	LOOMIS SAYLES & CO L P	1.81%	1.48M	46.09M	-69.19K	-4.46%
Dec 31, 2025	MORGAN STANLEY	2.13%	1.74M	54.09M	1.55M	+805.60%
Dec 31, 2025	FISHER ASSET MANAGEMENT, LLC	2.18%	1.78M	55.4M	579.06K	+48.21%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.44%	1.99M	62.01M	225.99K	+12.80%
Dec 31, 2025	DEEP TRACK CAPITAL, LP	3.09%	2.52M	78.57M	-2.86M	-53.07%
Sep 30, 2025	TANG CAPITAL MANAGEMENT LLC	3.48%	2.84M	61.35M	0	0
Sep 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	3.2%	2.61M	56.31M	-132.22K	-4.82%
Sep 30, 2025	IKARIAN CAPITAL, LLC	0.3%	245.52K	5.3M	-224.43K	-47.76%
Sep 30, 2025	FAIRMOUNT FUNDS MANAGEMENT LLC	4.24%	3.46M	74.66M	0	0
Sep 30, 2025	VR ADVISER, LLC	4.76%	3.88M	83.79M	0	0
Sep 30, 2025	VANGUARD GROUP INC	5.31%	4.33M	93.48M	-176.53K	-3.92%
Sep 30, 2025	KYNAM CAPITAL MANAGEMENT, LP	5.43%	4.43M	95.55M	0	0
Sep 30, 2025	DEEP TRACK CAPITAL, LP	6.59%	5.38M	116.11M	0	0
Sep 30, 2025	BLACKROCK, INC.	6.65%	5.43M	117.15M	-92.51K	-1.68%
Sep 30, 2025	FMR LLC	15.01%	12.25M	264.34M	10.55K	+0.09%
Sep 30, 2025	COMMODORE CAPITAL LP	3.92%	3.2M	69.06M	-1.68M	-34.36%
Sep 30, 2025	ALPS ADVISORS INC	0.05%	39.96K	862.36K	-4.01K	-9.12%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.05%	43.63K	941.51K	0	0
Sep 30, 2025	SIMPLIFY ASSET MANAGEMENT INC.	0.06%	50K	1.08M	50K	+100.00%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.06%	51.24K	1.11M	-53.33K	-51.00%
Sep 30, 2025	J. SAFRA SARASIN HOLDING AG	0.06%	51.7K	1.12M	-119.42K	-69.79%
Sep 30, 2025	KNIGHTS OF COLUMBUS ASSET ADVISORS LLC	0.07%	59.41K	1.28M	1.39K	+2.39%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.07%	59.98K	1.29M	0	0
Sep 30, 2025	DCF ADVISERS, LLC	0.08%	62.03K	1.34M	0	0
Sep 30, 2025	SG AMERICAS SECURITIES, LLC	0.08%	62.12K	1.34M	49.98K	+411.81%
Sep 30, 2025	Y-INTERCEPT (HONG KONG) LTD	0.08%	64.59K	1.39M	52.41K	+430.33%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.08%	68.07K	1.47M	-8.35K	-10.92%
Sep 30, 2025	MOODY ALDRICH PARTNERS LLC	0.09%	74.11K	1.6M	-15.05K	-16.88%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.1%	78.8K	1.7M	-10.8K	-12.05%
Sep 30, 2025	INVESCO LTD.	0.1%	80.79K	1.74M	18.58K	+29.86%
Sep 30, 2025	PROPEL BIO MANAGEMENT, LLC	0.11%	90K	1.94M	90K	+100.00%
Sep 30, 2025	MERCK & CO., INC.	0.11%	93.41K	2.02M	0	0
Sep 30, 2025	RHUMBLINE ADVISERS	0.13%	104.36K	2.25M	-3.03K	-2.82%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.13%	105.88K	2.28M	26.1K	+32.71%
Sep 30, 2025	SWISS NATIONAL BANK	0.14%	110.7K	2.39M	1.8K	+1.65%
Sep 30, 2025	KNOTT DAVID M JR	0.14%	116.57K	2.52M	25.09K	+27.43%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.17%	135K	2.91M	47.11K	+53.61%
Sep 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.19%	154.34K	3.33M	-13.99K	-8.31%
Sep 30, 2025	MACQUARIE GROUP LTD	0.19%	154.74K	3.34M	-2.43K	-1.54%
Sep 30, 2025	NUVEEN, LLC	0.2%	161.87K	3.49M	-61.37K	-27.49%
Sep 30, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.21%	175.25K	3.78M	55.69K	+46.58%
Sep 30, 2025	KOPP FAMILY OFFICE, LLC	0.24%	193.83K	4.18M	-9.4K	-4.63%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.24%	197.17K	4.25M	4.65K	+2.41%
Sep 30, 2025	BARCLAYS PLC	0.26%	208.25K	4.49M	-22.86K	-9.89%
Sep 30, 2025	PRINCIPAL FINANCIAL GROUP INC	0.26%	213.33K	4.6M	9.49K	+4.66%
Sep 30, 2025	NOVO HOLDINGS A/S	2.92%	2.38M	51.36M	0	0
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.3%	242.31K	5.23M	52.08K	+27.38%
Sep 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.42%	344.08K	7.43M	-32.76K	-8.69%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.78%	638.78K	13.79M	153.08K	+31.52%
Sep 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.29%	1.05M	22.65M	-216.37K	-17.09%
Sep 30, 2025	YIHENG CAPITAL MANAGEMENT, L.P.	0.61%	500.26K	10.8M	0	0
Sep 30, 2025	ROSALIND ADVISORS, INC.	0.74%	600K	12.95M	-100K	-14.29%
Sep 30, 2025	NORTHERN TRUST CORP	0.76%	620.86K	13.4M	23.98K	+4.02%
Sep 30, 2025	5AM VENTURE MANAGEMENT, LLC	0.9%	736.6K	15.9M	0	0
Sep 30, 2025	GOLDMAN SACHS GROUP INC	0.94%	764.56K	16.5M	-135.26K	-15.03%
Sep 30, 2025	RICE HALL JAMES & ASSOCIATES, LLC	1.04%	851.66K	18.38M	336.04K	+65.17%
Sep 30, 2025	MARSHALL WACE, LLP	1.07%	869.19K	18.76M	-338.68K	-28.04%
Sep 30, 2025	CANDRIAM S.C.A.	1.05%	860.23K	18.56M	-2.04K	-0.24%
Sep 30, 2025	FISHER ASSET MANAGEMENT, LLC	1.47%	1.2M	25.92M	691.27K	+135.55%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.5%	1.22M	26.33M	111.54K	+10.06%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.3%	245.76K	5.3M	14.92K	+6.46%
Sep 30, 2025	AFFINITY ASSET ADVISORS, LLC	0.31%	250K	5.4M	-140K	-35.90%
Sep 30, 2025	ROYAL BANK OF CANADA	0.45%	368.6K	7.96M	22.7K	+6.56%
Sep 30, 2025	PANAGORA ASSET MANAGEMENT INC	0.46%	377.71K	8.15M	25.86K	+7.35%
Sep 30, 2025	NATIONALE-NEDERLANDEN POWSZECHNE TOWARZYSTWO EMERYTALNE S.A.	0.52%	423.27K	9.13M	0	0
Sep 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.53%	432.42K	9.33M	-132.37K	-23.44%
Sep 30, 2025	HIGHVISTA STRATEGIES LLC	0.58%	469.34K	10.13M	-15.22K	-3.14%
Sep 30, 2025	DEUTSCHE BANK AG\	1.15%	937.47K	20.23M	550.53K	+142.28%
Sep 30, 2025	VIVO CAPITAL, LLC	1.2%	982.58K	21.2M	0	0
Sep 30, 2025	PERCEPTIVE ADVISORS LLC	1.79%	1.46M	31.56M	1.01M	+226.79%
Sep 30, 2025	LOOMIS SAYLES & CO L P	1.9%	1.55M	33.46M	211.86K	+15.83%
Sep 30, 2025	BAKER BROS. ADVISORS LP	2.14%	1.74M	37.64M	0	0
Sep 30, 2025	ALLIANCEBERNSTEIN L.P.	2.28%	1.86M	40.13M	-84.56K	-4.35%
Sep 30, 2025	EVERSEPT PARTNERS, LP	2.36%	1.92M	41.53M	21.77K	+1.14%
Sep 30, 2025	MAVERICK CAPITAL LTD	2.71%	2.21M	47.75M	-44.31K	-1.96%
Sep 30, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.32%	259.51K	5.6M	259.51K	+100.00%
Sep 30, 2025	JPMORGAN CHASE & CO	0.38%	309.13K	6.67M	-106.86K	-25.69%
Sep 30, 2025	RAYMOND JAMES FINANCIAL INC	0.38%	312.76K	6.75M	-19.33K	-5.82%
Sep 30, 2025	UBS GROUP AG	0.55%	447.68K	9.66M	-85.97K	-16.11%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.73%	595.36K	12.85M	21.34K	+3.72%
Sep 30, 2025	WOODLINE PARTNERS LP	1%	815.49K	17.6M	0	0
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	1.38%	1.12M	24.22M	851.99K	+314.92%
Sep 30, 2025	PARKMAN HEALTHCARE PARTNERS LLC	1.41%	1.15M	24.91M	-144.34K	-11.11%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.16%	1.77M	38.12M	25.57K	+1.47%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.96%	2.42M	52.18M	-477.16K	-16.48%
Sep 30, 2025	STATE STREET CORP	3.13%	2.55M	55.12M	740	+0.03%
Jun 30, 2025	ROSALIND ADVISORS, INC.	0.86%	700K	9.79M	105K	+17.65%
Jun 30, 2025	TANG CAPITAL MANAGEMENT LLC	3.48%	2.84M	39.74M	50K	+1.79%
Jun 30, 2025	LOOMIS SAYLES & CO L P	1.64%	1.34M	18.71M	-31.88K	-2.33%
Jun 30, 2025	PARKMAN HEALTHCARE PARTNERS LLC	1.59%	1.3M	18.16M	234.32K	+22.01%
Jun 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.55%	1.27M	17.7M	17.03K	+1.36%
Jun 30, 2025	VIVO CAPITAL, LLC	1.2%	982.58K	13.74M	0	0
Jun 30, 2025	GOLDMAN SACHS GROUP INC	1.1%	899.83K	12.58M	-331.27K	-26.91%
Jun 30, 2025	CANDRIAM S.C.A.	1.06%	862.27K	12.06M	-18.16K	-2.06%
Jun 30, 2025	WOODLINE PARTNERS LP	1%	815.49K	11.4M	1.84K	+0.23%
Jun 30, 2025	CITADEL ADVISORS LLC	0.8%	649.54K	9.08M	561K	+633.56%
Jun 30, 2025	NORTHERN TRUST CORP	0.73%	596.88K	8.34M	-105.63K	-15.04%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.7%	574.02K	8.02M	8.06K	+1.42%
Jun 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.69%	564.79K	7.9M	11.94K	+2.16%
Jun 30, 2025	UBS GROUP AG	0.65%	533.64K	7.46M	29.46K	+5.84%
Jun 30, 2025	YIHENG CAPITAL MANAGEMENT, L.P.	0.61%	500.26K	6.99M	0	0
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.6%	485.7K	6.79M	485.7K	+100.00%
Jun 30, 2025	HIGHVISTA STRATEGIES LLC	0.59%	484.56K	6.77M	304.01K	+168.38%
Jun 30, 2025	IKARIAN CAPITAL, LLC	0.58%	469.95K	6.57M	-25K	-5.05%
Jun 30, 2025	PERCEPTIVE ADVISORS LLC	0.55%	447.51K	6.26M	-212.16K	-32.16%
Jun 30, 2025	ROYAL BANK OF CANADA	0.42%	345.9K	4.84M	345.69K	+162,293.43%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.13%	1.74M	24.34M	20.09K	+1.17%
Jun 30, 2025	MARSHALL WACE, LLP	1.48%	1.21M	16.89M	123.83K	+11.42%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.36%	1.11M	15.5M	-6K	-0.54%
Jun 30, 2025	5AM VENTURE MANAGEMENT, LLC	0.9%	736.6K	10.3M	0	0
Jun 30, 2025	RICE HALL JAMES & ASSOCIATES, LLC	0.63%	515.62K	7.21M	152.73K	+42.09%
Jun 30, 2025	FISHER ASSET MANAGEMENT, LLC	0.63%	509.96K	7.13M	-27.07K	-5.04%
Jun 30, 2025	NATIONALE-NEDERLANDEN POWSZECHNE TOWARZYSTWO EMERYTALNE S.A.	0.52%	423.27K	5.92M	0	0
Jun 30, 2025	JPMORGAN CHASE & CO	0.51%	415.99K	5.82M	117.44K	+39.34%
Jun 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.46%	376.85K	5.27M	-893.64K	-70.34%
Jun 30, 2025	FMR LLC	15%	12.24M	171.1M	15.82K	+0.13%
Jun 30, 2025	BLACKROCK, INC.	6.77%	5.52M	77.18M	-187.08K	-3.28%
Jun 30, 2025	DEEP TRACK CAPITAL, LP	6.59%	5.38M	75.22M	0	0
Jun 30, 2025	COMMODORE CAPITAL LP	5.97%	4.88M	68.15M	1.28M	+35.42%
Jun 30, 2025	VANGUARD GROUP INC	5.53%	4.51M	63.03M	-54.59K	-1.20%
Jun 30, 2025	KYNAM CAPITAL MANAGEMENT, LP	5.43%	4.43M	61.9M	-272.07K	-5.79%
Jun 30, 2025	VR ADVISER, LLC	4.76%	3.88M	54.28M	0	0
Jun 30, 2025	FAIRMOUNT FUNDS MANAGEMENT LLC	4.24%	3.46M	48.37M	14.1K	+0.41%
Jun 30, 2025	PANAGORA ASSET MANAGEMENT INC	0.43%	351.85K	4.92M	-2.89K	-0.81%
Jun 30, 2025	RAYMOND JAMES FINANCIAL INC	0.41%	332.09K	4.64M	13.85K	+4.35%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.33%	270.54K	3.78M	21.37K	+8.58%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	3.55%	2.9M	40.48M	1.21M	+71.51%
Jun 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	3.36%	2.74M	38.33M	646.5K	+30.86%
Jun 30, 2025	STATE STREET CORP	3.13%	2.55M	35.7M	-312.07K	-10.89%
Jun 30, 2025	NOVO HOLDINGS A/S	2.92%	2.38M	33.27M	129.7K	+5.76%
Jun 30, 2025	MAVERICK CAPITAL LTD	2.77%	2.26M	31.55M	195.74K	+9.50%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	2.38%	1.94M	27.18M	-77.6K	-3.84%
Jun 30, 2025	EVERSEPT PARTNERS, LP	2.33%	1.9M	26.6M	524.87K	+38.10%
Jun 30, 2025	BAKER BROS. ADVISORS LP	2.14%	1.74M	24.39M	1.74M	+100.00%
Jun 30, 2025	AFFINITY ASSET ADVISORS, LLC	0.48%	390K	5.45M	0	0
Jun 30, 2025	DEUTSCHE BANK AG\	0.47%	386.94K	5.41M	-9.87K	-2.49%
Mar 31, 2025	PARADIGM BIOCAPITAL ADVISORS LP	2.58%	2.1M	28.24M	275K	+15.11%
Mar 31, 2025	VIVO CAPITAL, LLC	1.21%	982.58K	13.25M	0	0
Mar 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.54%	1.25M	16.83M	0	0
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.08%	1.69M	22.76M	361.32K	+27.23%
Mar 31, 2025	EVERSEPT PARTNERS, LP	1.69%	1.38M	18.57M	597.68K	+76.63%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.12%	1.72M	23.2M	61.55K	+3.71%
Mar 31, 2025	UBS GROUP AG	0.62%	504.19K	6.8M	-7.89K	-1.54%
Mar 31, 2025	FISHER ASSET MANAGEMENT, LLC	0.66%	537.02K	7.24M	19K	+3.67%
Mar 31, 2025	NORTHERN TRUST CORP	0.86%	702.52K	9.47M	8.38K	+1.21%
Mar 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	1.56%	1.27M	17.13M	-605.4K	-32.27%
Mar 31, 2025	DEUTSCHE BANK AG\	0.49%	396.81K	5.35M	-6.07K	-1.51%
Mar 31, 2025	NATIONALE-NEDERLANDEN POWSZECHNE TOWARZYSTWO EMERYTALNE S.A.	0.52%	423.27K	5.71M	0	0
Mar 31, 2025	OCTAGON CAPITAL ADVISORS LP	0.55%	450K	6.07M	-420K	-48.28%
Mar 31, 2025	IKARIAN CAPITAL, LLC	0.61%	494.95K	6.67M	25K	+5.32%
Mar 31, 2025	YIHENG CAPITAL MANAGEMENT, L.P.	0.62%	500.26K	6.74M	-250K	-33.32%
Mar 31, 2025	LOOMIS SAYLES & CO L P	1.68%	1.37M	18.47M	-30.03K	-2.14%
Mar 31, 2025	ALLIANCEBERNSTEIN L.P.	2.49%	2.02M	27.25M	-265.38K	-11.60%
Mar 31, 2025	MAVERICK CAPITAL LTD	2.53%	2.06M	27.79M	7.37K	+0.36%
Mar 31, 2025	BLACKROCK, INC.	7.02%	5.71M	76.95M	-50.47K	-0.88%
Mar 31, 2025	PARKMAN HEALTHCARE PARTNERS LLC	1.31%	1.06M	14.35M	-23.13K	-2.13%
Mar 31, 2025	DEEP TRACK CAPITAL, LP	6.61%	5.38M	72.53M	857.71K	+18.96%
Mar 31, 2025	AFFINITY ASSET ADVISORS, LLC	0.48%	390K	5.26M	230.39K	+144.34%
Mar 31, 2025	JPMORGAN CHASE & CO	0.37%	298.55K	4.02M	-5.78K	-1.90%
Mar 31, 2025	RAYMOND JAMES FINANCIAL INC	0.39%	318.24K	4.29M	4.45K	+1.42%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.39%	320.3K	4.32M	-50.9K	-13.71%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	1.51%	1.23M	16.6M	311K	+33.80%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.27%	222.4K	3M	-202.14K	-47.61%
Mar 31, 2025	VANGUARD GROUP INC	5.61%	4.56M	61.51M	-31.95K	-0.70%
Mar 31, 2025	KYNAM CAPITAL MANAGEMENT, LP	5.78%	4.7M	63.36M	1.37M	+41.30%
Mar 31, 2025	VICTORY CAPITAL MANAGEMENT INC	0.68%	552.85K	7.45M	142.41K	+34.70%
Mar 31, 2025	PANAGORA ASSET MANAGEMENT INC	0.44%	354.74K	4.78M	101.72K	+40.20%
Mar 31, 2025	ROSALIND ADVISORS, INC.	0.73%	595K	8.02M	595K	+100.00%
Mar 31, 2025	PERCEPTIVE ADVISORS LLC	0.81%	659.66K	8.89M	-826.85K	-55.62%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.7%	565.96K	7.63M	-9.11K	-1.58%
Mar 31, 2025	FMR LLC	15.03%	12.22M	164.77M	341.07K	+2.87%
Mar 31, 2025	MORGAN STANLEY	0.42%	341.8K	4.61M	-397.35K	-53.76%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.37%	297.97K	4.02M	-68.01K	-18.58%
Mar 31, 2025	RICE HALL JAMES & ASSOCIATES, LLC	0.45%	362.89K	4.89M	309.52K	+579.89%
Mar 31, 2025	CANDRIAM S.C.A.	1.08%	880.43K	11.87M	149.21K	+20.41%
Mar 31, 2025	GREAT POINT PARTNERS LLC	0.92%	750K	10.11M	0	0
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.31%	249.17K	3.36M	24.69K	+11.00%
Mar 31, 2025		0.31%	248.63K	3.35M	248.63K	+100.00%
Mar 31, 2025	WOODLINE PARTNERS LP	1%	813.65K	10.97M	0	0
Mar 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.37%	1.11M	15.02M	-555.41K	-33.26%
Mar 31, 2025	MARSHALL WACE, LLP	1.33%	1.08M	14.61M	1.08M	+100.00%
Mar 31, 2025	VR ADVISER, LLC	4.77%	3.88M	52.34M	0	0
Mar 31, 2025	COMMODORE CAPITAL LP	4.43%	3.6M	48.53M	1.2M	+50.00%
Mar 31, 2025	STATE STREET CORP	3.52%	2.87M	38.63M	-657.07K	-18.65%
Mar 31, 2025	TANG CAPITAL MANAGEMENT LLC	3.43%	2.79M	37.65M	300K	+12.03%
Mar 31, 2025	NOVO HOLDINGS A/S	2.77%	2.25M	30.33M	300	+0.01%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.05%	24.24K	424.39K	8.18K	+50.96%
Mar 31, 2024	AMERICAN INTERNATIONAL GROUP, INC.	0.05%	24.52K	429.26K	3.27K	+15.37%
Mar 31, 2024	METLIFE INVESTMENT MANAGEMENT, LLC	0.06%	25.57K	447.73K	3.3K	+14.81%
Mar 31, 2024	STONECREST WEALTH MANAGEMENT, INC.	0.06%	27.68K	484.59K	-116	-0.42%
Mar 31, 2024	LIGHTHOUSE INVESTMENT PARTNERS, LLC	0.06%	28.41K	497.39K	28.41K	+100.00%
Mar 31, 2024	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.06%	28.82K	628.68K	1.14K	+4.10%
Mar 31, 2024	WELLS FARGO & COMPANY/MN	0.07%	32.13K	562.56K	6.24K	+24.08%
Mar 31, 2024	ALGERT GLOBAL LLC	0.08%	37.82K	662K	37.82K	+100.00%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.09%	39.09K	684.41M	4.52K	+13.08%
Mar 31, 2024	ALPS ADVISORS INC	0.1%	44.28K	775.27K	9.42K	+27.03%
Mar 31, 2024	CREDIT SUISSE AG/	0.11%	47.88K	838.33K	6.81K	+16.59%
Mar 31, 2024	PROFUND ADVISORS LLC	0.14%	63.01K	1.1B	30.02K	+90.99%
Mar 31, 2024	RHUMBLINE ADVISERS	0.15%	67.52K	1.18M	7.09K	+11.73%
Mar 31, 2024	KNIGHTS OF COLUMBUS ASSET ADVISORS LLC	0.18%	78.82K	1.38M	-75.13K	-48.80%
Mar 31, 2024	SWISS NATIONAL BANK	0.19%	82.9K	1.45M	15.7K	+23.36%
Mar 31, 2024	HENNION & WALSH ASSET MANAGEMENT, INC.	0.25%	109.82K	1.92M	34.04K	+44.92%
Mar 31, 2024	EVERSEPT PARTNERS, LP	0.32%	142.08K	2.49M	4.73K	+3.45%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.34%	151.86K	2.66M	2.05K	+1.37%
Mar 31, 2024	JPMORGAN CHASE & CO	0.11%	49.02K	858.39K	-7.92K	-13.90%
Mar 31, 2024	PARADIGM BIOCAPITAL ADVISORS LP	11.24%	5.03M	88.1M	236.93K	+4.94%
Mar 31, 2024	NORTHERN TRUST CORP	1.03%	462.68K	8.1M	49.04K	+11.86%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	1.06%	475.73K	8.33M	189.29K	+66.08%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	3.85%	1.72M	30.17M	-336.65K	-16.35%
Mar 31, 2024	VANGUARD GROUP INC	7.23%	3.23M	56.63M	233.33K	+7.78%
Mar 31, 2024	BLACKROCK INC.	8.52%	3.81M	66.76M	386.18K	+11.27%
Mar 31, 2024	FMR LLC	21.04%	9.42M	164.86M	1.79M	+23.47%
Mar 31, 2024	KOPP FAMILY OFFICE, LLC	0.46%	205.64K	3.6M	40	+0.02%
Mar 31, 2024	KOPP LEROY C	0.46%	205.64K	3.6M	205.64K	+100.00%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.51%	226.85K	3.97M	226.85K	+100.00%
Mar 31, 2024	WELLINGTON MANAGEMENT GROUP LLP	0.54%	240.83K	4.22M	48.73K	+25.37%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.58%	261.7K	4.58M	248.3K	+1,852.99%
Mar 31, 2024	CUTTER CAPITAL MANAGEMENT, LP	0.62%	278.64K	4.88M	-29.08K	-9.45%
Mar 31, 2024	ROSALIND ADVISORS, INC.	0.67%	300K	5.25M	-60.33K	-16.74%
Mar 31, 2024	TWO SIGMA ADVISERS, LP	0.68%	304.4K	5.33M	204.1K	+203.49%
Mar 31, 2024	RUSSELL INVESTMENTS GROUP, LTD.	0.72%	321.61K	5.63M	-7.88K	-2.39%
Mar 31, 2024	SOLEUS CAPITAL MANAGEMENT, L.P.	0.76%	340K	5.95M	202K	+146.38%
Mar 31, 2024	CITIGROUP INC	0.78%	347.91K	6.09M	263.63K	+312.77%
Mar 31, 2024	UBS GROUP AG	0.85%	379.58K	6.65M	236.2K	+164.73%
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	0.91%	408.89K	7.16M	206.4K	+101.93%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.95%	424.09K	7.43M	52.77K	+14.21%
Mar 31, 2024	EAGLE ASSET MANAGEMENT INC	0.98%	438.77K	7.57M	-14.54K	-3.21%
Mar 31, 2024	WOODLINE PARTNERS LP	0.98%	438.92K	7.69M	438.92K	+100.00%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	1.21%	543.14K	9.51M	161.4K	+42.28%
Mar 31, 2024	MORGAN STANLEY	1.26%	562.54K	9.85M	37.64K	+7.17%
Mar 31, 2024	RTW INVESTMENTS, LP	1.35%	605.82K	10.61M	0	0
Mar 31, 2024	BIOIMPACT CAPITAL LLC	1.37%	614.01K	10.75M	514.01K	+514.01%
Mar 31, 2024	OCTAGON CAPITAL ADVISORS LP	1.39%	620K	10.86M	0	0
Mar 31, 2024	GHOST TREE CAPITAL, LLC	1.4%	625K	10.94M	325K	+108.33%
Mar 31, 2024	TANG CAPITAL MANAGEMENT LLC	1.55%	692.93K	12.13M	0	0
Mar 31, 2024	LOGOS GLOBAL MANAGEMENT LP	1.56%	700K	12.26M	100K	+16.67%
Mar 31, 2024	5AM VENTURE MANAGEMENT, LLC	1.65%	736.6K	12.9M	150K	+25.57%
Mar 31, 2024	POLAR CAPITAL HOLDINGS PLC	1.99%	889.2K	15.57M	-90.72K	-9.26%
Mar 31, 2024	YIHENG CAPITAL MANAGEMENT, L.P.	2.12%	948.13K	16.6M	-280.4K	-22.82%
Mar 31, 2024	FISHER ASSET MANAGEMENT, LLC	0.87%	389.09K	6.81M	389.09K	+100.00%
Mar 31, 2024	CITADEL ADVISORS LLC	1.7%	762.41K	13.35M	-124.23K	-14.01%
Mar 31, 2024	PICTET ASSET MANAGEMENT HOLDING SA	2.45%	1.1M	19.18M	44.57K	+4.24%
Mar 31, 2024	NOVO HOLDINGS A/S	2.46%	1.1M	19.26M	1.1M	+100.00%
Mar 31, 2024	VR ADVISER, LLC	8.68%	3.88M	67.99M	48	0.00%
Mar 31, 2024	STATE STREET CORP	10.03%	4.49M	78.6M	1.78M	+65.73%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	0.02%	10.07K	176.33K	0	0
Mar 31, 2024	ARIZONA STATE RETIREMENT SYSTEM	0.03%	11.49K	201.19K	1.96K	+20.53%
Mar 31, 2024	RAYMOND JAMES & ASSOCIATES	0.03%	11.55K	202.22K	1.32K	+12.92%
Mar 31, 2024	PRINCIPAL FINANCIAL GROUP INC	0.03%	11.92K	208.63K	1.06K	+9.74%
Mar 31, 2024	NEW YORK STATE COMMON RETIREMENT FUND	0.04%	17.95K	314K	451	+2.58%
Mar 31, 2024	INVESCO LTD.	0.04%	18.73K	327.96K	-126.04K	-87.06%
Mar 31, 2024	E FUND MANAGEMENT CO., LTD.	0.04%	19.32K	338.35K	8.45K	+77.68%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.05%	21.2K	371.21K	21.2K	+100.00%
Mar 31, 2024	STATE OF WISCONSIN INVESTMENT BOARD	0.05%	22.27K	389.95K	-36.06K	-61.82%
Mar 31, 2024	CANDRIAM S.C.A.	0.63%	280K	4.9M	280K	+100.00%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	2.6%	1.16M	20.39M	169.8K	+17.07%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	2.98%	1.33M	23.33M	1.1M	+469.72%
Mar 31, 2024	GREAT POINT PARTNERS LLC	2.98%	1.34M	23.38M	1.34M	+100.00%
Mar 31, 2024	VIVO CAPITAL, LLC	3.75%	1.68M	29.39M	0	0
Mar 31, 2024	FAIRMOUNT FUNDS MANAGEMENT LLC	4.12%	1.85M	32.32M	476.19K	+34.77%
Mar 31, 2024	COMMODORE CAPITAL LP	4.32%	1.93M	33.88M	10.58K	+0.55%
Mar 31, 2024	MAVERICK CAPITAL LTD	6.02%	2.69M	47.14M	366.57K	+15.76%
Mar 31, 2024	DEEP TRACK CAPITAL, LP	7.72%	3.46M	60.52M	-175.68K	-4.84%
Mar 31, 2024	PERCEPTIVE ADVISORS LLC	8.17%	3.66M	64.04M	1.93M	+111.37%
Dec 31, 2023	PARADIGM BIOCAPITAL ADVISORS LP	10.98%	4.79M	104.42M	1.11M	+30.22%
Dec 31, 2023	VR ADVISER, LLC	8.89%	3.88M	84.56M	800K	+25.95%
Dec 31, 2023	DEEP TRACK CAPITAL, LP	8.32%	3.63M	79.1M	668.46K	+22.56%
Dec 31, 2023	BLACKROCK INC.	7.85%	3.43M	74.63M	433.39K	+14.48%
Dec 31, 2023	VANGUARD GROUP INC	6.87%	3M	65.36M	552.93K	+22.59%
Dec 31, 2023	STATE STREET CORP	6.2%	2.71M	58.99M	-233.31K	-7.93%
Dec 31, 2023	MAVERICK CAPITAL LTD	5.33%	2.33M	50.66M	2.33M	+100.00%
Dec 31, 2023	ALLIANCEBERNSTEIN L.P.	4.72%	2.06M	44.86M	168.47K	+8.91%
Dec 31, 2023	PERCEPTIVE ADVISORS LLC	3.96%	1.73M	37.68M	719.01K	+71.10%
Dec 31, 2023	VIVO CAPITAL, LLC	3.84%	1.68M	36.55M	0	0
Dec 31, 2023	FAIRMOUNT FUNDS MANAGEMENT LLC	3.14%	1.37M	29.83M	0	0
Dec 31, 2023	YIHENG CAPITAL MANAGEMENT, L.P.	2.81%	1.23M	26.76M	0	0
Dec 31, 2023		0.7%	307.72K	6.7M	307.72K	+100.00%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	2.28%	994.47K	21.66M	135.37K	+15.76%
Dec 31, 2023	POLAR CAPITAL HOLDINGS PLC	2.24%	979.92K	21.34M	-620.08K	-38.76%
Dec 31, 2023	CITADEL ADVISORS LLC	2.03%	886.64K	19.31M	784.21K	+765.60%
Dec 31, 2023	TANG CAPITAL MANAGEMENT LLC	1.59%	692.93K	15.09M	23.8K	+3.56%
Dec 31, 2023	OCTAGON CAPITAL ADVISORS LP	1.42%	620K	13.5M	-447.14K	-41.90%
Dec 31, 2023	KYNAM CAPITAL MANAGEMENT, LP	1.39%	607.92K	13.24M	-91.77K	-13.12%
Dec 31, 2023	RTW INVESTMENTS, LP	1.39%	605.82K	13.19M	605.82K	+100.00%
Dec 31, 2023	LOGOS GLOBAL MANAGEMENT LP	1.37%	600K	13.07M	-450K	-42.86%
Dec 31, 2023	5AM VENTURE MANAGEMENT, LLC	1.34%	586.6K	12.78M	176.6K	+43.07%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.87%	381.74K	8.31M	-17.54K	-4.39%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.85%	371.31K	8.09M	58.09K	+18.55%
Dec 31, 2023	KNIGHTS OF COLUMBUS ASSET ADVISORS LLC	0.35%	153.95K	3.35M	124.4K	+420.93%
Dec 31, 2023	POLAR ASSET MANAGEMENT PARTNERS INC.	0.37%	159.7K	3.48M	83.1K	+108.49%
Dec 31, 2023	SCHONFELD STRATEGIC ADVISORS LLC	0.41%	178.92K	3.9M	70.88K	+65.61%
Dec 31, 2023	WELLINGTON MANAGEMENT GROUP LLP	0.44%	192.1K	4.18M	192.1K	+100.00%
Dec 31, 2023	HIGHVISTA STRATEGIES LLC	0.45%	198.48K	4.32M	93.73K	+89.47%
Dec 31, 2023	RAFFERTY ASSET MANAGEMENT, LLC	0.46%	202.49K	4.41M	-59.81K	-22.80%
Dec 31, 2023	COMMODORE CAPITAL LP	4.41%	1.92M	41.91M	-275.93K	-12.54%
Dec 31, 2023	KOPP FAMILY OFFICE, LLC	0.47%	205.6K	4.48M	-8.69K	-4.06%
Dec 31, 2023	BARCLAYS PLC	0.5%	219.59K	4.78M	88.04K	+66.92%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	0.51%	224.79K	4.9M	-1.16M	-83.72%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.54%	233.88K	5.09M	30.44K	+14.96%
Dec 31, 2023	WALLEYE CAPITAL LLC	0.55%	241.41K	5.26M	227.88K	+1,684.26%
Dec 31, 2023	ACUTA CAPITAL PARTNERS, LLC	0.64%	281.5K	6.13M	57.16K	+25.48%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.66%	286.45K	6.24M	81.23K	+39.58%
Dec 31, 2023	ROSALIND ADVISORS, INC.	0.83%	360.33K	7.85M	360.33K	+100.00%
Dec 31, 2023	GHOST TREE CAPITAL, LLC	0.69%	300K	6.53M	25K	+9.09%
Dec 31, 2023	MARSHALL WACE, LLP	0.69%	301.29K	6.56M	-661.2K	-68.70%
Dec 31, 2023	BRAIDWELL LP	0.74%	323.1K	7.04M	-1.41M	-81.38%
Dec 31, 2023	RUSSELL INVESTMENTS GROUP, LTD.	0.75%	329.48K	7.18M	30.34K	+10.14%
Dec 31, 2023	JEFFERIES FINANCIAL GROUP INC.	1.24%	540.67K	11.78M	540.67K	+100.00%
Dec 31, 2023	MORGAN STANLEY	1.2%	524.9K	11.43M	191.18K	+57.29%
Dec 31, 2023	EAGLE ASSET MANAGEMENT INC	1.04%	453.31K	9.87M	-5.86K	-1.28%
Dec 31, 2023	NORTHERN TRUST CORP	0.95%	413.64K	9.01M	11.98K	+2.98%
Dec 31, 2023	FMR LLC	17.47%	7.63M	166.08M	7.36M	+2,808.43%

Insiders

Among the VRDN insiders holding of 0.14% of the stake in company, FAIRMOUNT FUNDS MANAGEMENT LLC, , holds the largest shares of 3.91M. FRAZIER LIFE SCIENCES PUBLIC FUND, L.P., 10 percent owner, is the second largest VRDN insider with ownership of 1.51M shares. FAIRMOUNT HEALTHCARE FUND II L.P., , stands third with possession of 1.36M shares of that stake.

Insiders	Designation	Shares Held
FAIRMOUNT FUNDS MANAGEMENT LLC		3.91M
FRAZIER LIFE SCIENCES PUBLIC FUND, L.P.	10 percent owner	1.51M
FAIRMOUNT HEALTHCARE FUND II L.P.		1.36M
BOOTH BRUCE	director	1.35M
LOGOS GLOBAL MASTER FUND LP	10 percent owner	550K
LEFKOFF KYLE	director	463.47K
VIOLIN JONATHAN	Chief Executive Officer	430.91K
RICCITELLI SAMUEL D	President & CEO	345.13K
MYERS SCOTT DUNSETH	Chief Executive Officer	259.5K
MEISNER LARA	Chief Legal Officer	29.97K
MAHONEY STEPHEN F.	President and CEO	21.4K
HUGHES THOMAS E.	director	12.83K
LEVY ADAM SCOTT	Chief Business Officer	10.54K
BEETHAM THOMAS W.	Chief Operating Officer	6K
KATZ BARRETT	Chief Medical Officer	0
TOUSIGNANT JENNIFER	Chief Legal Officer	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Dec 31, 2025	TOUSIGNANT JENNIFER	SALE	31.16	2.27K	70.8K	0
Oct 23, 2025	FAIRMOUNT FUNDS MANAGEMENT LLC	PURCHASE	22.00	454.55K	10M	3.91M
Sep 27, 2024	MAHONEY STEPHEN F.	PURCHASE	23.33	21.4K	499.26K	21.4K
Sep 27, 2024	BEETHAM THOMAS W.	PURCHASE	23.41	5K	117.05K	6K
Sep 13, 2024	FAIRMOUNT FUNDS MANAGEMENT LLC	PURCHASE	18.75	1.6M	30M	3.45M
Jan 22, 2024	FAIRMOUNT FUNDS MANAGEMENT LLC	PURCHASE	21.00	476.19K	10M	1.84M
Jun 16, 2023	MEISNER LARA	SALE	28.35	27	765.45	29.97K
Jun 15, 2023	MEISNER LARA	SALE	28.02	2.27K	63.58K	29.97K
Jun 06, 2023	MEISNER LARA	SALE	25.02	5.13K	128.25K	29.97K
Jun 05, 2023	MEISNER LARA	SALE	25.03	499	12.49K	29.97K
Jun 02, 2023	MEISNER LARA	SALE	24.21	1.88K	45.39K	29.97K
Apr 12, 2023	MYERS SCOTT DUNSETH	PURCHASE	25.37	4K	101.48K	259.5K
Mar 13, 2023	MYERS SCOTT DUNSETH	PURCHASE	29.15	5.5K	160.32K	255.5K
Mar 09, 2023	MEISNER LARA	SALE	29.07	29.97K	871.26K	0
Feb 02, 2023	VIOLIN JONATHAN	SALE	36.80	50K	1.84M	430.91K
Jan 23, 2023	MEISNER LARA	SALE	35.66	6.84K	244.02K	0
Jan 17, 2023	KATZ BARRETT	SALE	37.21	24.85K	924.78K	0
Jan 10, 2023	KATZ BARRETT	SALE	35.30	47.38K	1.67M	0
Dec 21, 2022	MEISNER LARA	SALE	29.19	16.33K	476.56K	0
Dec 16, 2022	MEISNER LARA	SALE	28.44	1.3K	36.89K	0
Dec 14, 2022	MEISNER LARA	SALE	28.12	15.66K	440.25K	0
Nov 15, 2022	MEISNER LARA	SALE	22.05	8.13K	179.16K	0
Aug 17, 2022	FAIRMOUNT HEALTHCARE FUND II L.P.	PURCHASE	23.50	425.53K	10M	1.36M
Jun 01, 2022	VIOLIN JONATHAN	SALE	12.20	30K	366K	480.91K
May 02, 2022	VIOLIN JONATHAN	SALE	13.04	30K	391.2K	510.91K
Apr 01, 2022	VIOLIN JONATHAN	SALE	18.93	3.6K	68.15K	540.91K
Mar 02, 2022	VIOLIN JONATHAN	SALE	17.36	11.11K	192.8K	570.91K
Mar 01, 2022	VIOLIN JONATHAN	SALE	17.82	18.89K	336.69K	582.01K
Feb 03, 2022	VIOLIN JONATHAN	SALE	19.16	909	17.42K	600.91K
Feb 02, 2022	VIOLIN JONATHAN	SALE	18.47	12.34K	227.92K	601.81K
Feb 01, 2022	VIOLIN JONATHAN	SALE	19.55	16.75K	327.48K	614.15K
Sep 23, 2021	FRAZIER LIFE SCIENCES PUBLIC FUND, L.P.	PURCHASE	11.00	200K	2.2M	1.51M
Sep 21, 2021	FAIRMOUNT FUNDS MANAGEMENT LLC	PURCHASE	11.00	909K	10M	938.23K
Nov 13, 2020	LOGOS GLOBAL MASTER FUND LP	PURCHASE	14.84	126.67K	1.88M	550K
Nov 09, 2020	LOGOS GLOBAL MASTER FUND LP	PURCHASE	1.10	250K	274.48K	6.25M
Oct 30, 2020	FAIRMOUNT FUNDS MANAGEMENT LLC	PURCHASE	0.00	5.49K	-	22K
Oct 11, 2018	HUGHES THOMAS E.	PURCHASE	4.77	10K	47.7K	12.83K
Feb 13, 2018	LEVY ADAM SCOTT	PURCHASE	5.50	9.09K	50K	10.54K
Feb 13, 2018	BOOTH BRUCE	PURCHASE	5.50	545.45K	3M	1.35M
Dec 20, 2017	HUGHES THOMAS E.	SALE	8.00	12K	96K	2.83K
Jun 22, 2017	LEVY ADAM SCOTT	PURCHASE	7.55	200	1.51K	200
Mar 10, 2017	LEFKOFF KYLE	SALE	14.31	3.3K	47.23K	463.47K
Mar 09, 2017	LEFKOFF KYLE	SALE	14.38	2.5K	35.96K	466.77K
Mar 08, 2017	LEFKOFF KYLE	SALE	14.70	5K	73.51K	469.27K
Mar 06, 2017	LEFKOFF KYLE	SALE	16.24	608	9.87K	474.27K
Feb 28, 2017	LEFKOFF KYLE	SALE	13.54	2.26K	30.58K	484.27K
Feb 27, 2017	LEFKOFF KYLE	SALE	13.79	1.5K	20.69K	486.53K
Feb 24, 2017	LEFKOFF KYLE	SALE	14.04	6.5K	91.25K	488.03K
Feb 23, 2017	LEFKOFF KYLE	SALE	13.65	1.8K	24.57K	494.53K
Feb 22, 2017	LEFKOFF KYLE	SALE	14.36	4.1K	58.89K	496.33K
Nov 20, 2015	RICCITELLI SAMUEL D	PURCHASE	0.80	7K	5.6K	345.13K
Nov 19, 2015	RICCITELLI SAMUEL D	PURCHASE	0.78	7K	5.46K	338.13K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE454.55K1

SALES2.27K1

NET SHARES452.27K0

SHARES HELD3.91M2

% NET SHARES-88.45%-100%

Frequently Asked Questions