How many institutions own TNGX stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own TNGX shares is 193, representing 97.43% of the company's common stock.

Who are the major shareholders selling Tango Therapeutics, Inc. stock?

POINT72 ASSET MANAGEMENT, L.P., in the last quarter, reduced its stake in TNGX by -32.38% restricting it's holding to 1.97 million shares of worth nearly $17.49M. FISHER ASSET MANAGEMENT, LLC also lessened -10.77% of the TNGX shares from its portfolio, reducing its holding to 187.69 thousand shares of worth $1.66M. MARSHALL WACE, LLP also shunned TNGX shares holding by -77.9% last quarter which brought its holding to 329.23 thousand shares worth $2.92M.

Investors who are buying TNGX stock?

As per its latest 13F filing, CHARLES SCHWAB INVESTMENT MANAGEMENT INC increased its stake in TNGX by 27.75% in the last quarter. The institutional holder raised its holding to 840.99 thousand shares having worth more than $7.45M. BOOTHBAY FUND MANAGEMENT, LLC also added 100% more shares of TNGX to its portfolio, raising its holding to 957.28 thousand shares of worth $8.48M. D. E. SHAW & CO., INC. also increased its TNGX shares holding by 138.29% which brought its holding to 1.03 million shares worth $9.09M.

TNGX's major insiders: who are they?

The insider with the most stakes in TNGX is Third Rock Ventures IV, L.P. , 10 percent owner at the company. Additionally, TNGX stock is highly held by Boxer Capital, LLC and director Davis Aaron I. among others.

Did an insider recently sell TNGX stock?

Company executives, directors, and other insiders own 4.95% percent of Tango Therapeutics, Inc.'s stock. Within the last six months, there have been 8 transaction(s) in which TNGX insiders have sold stock, totaling 2.07M shares. Insiders that have sold shares include WEBER BARBARA, CRYSTAL ADAM, and BECKMAN DANIELLA.

Which insider recently purchased TNGX stock?

There have been 0 transaction(s) during the past 6-months in which Tango Therapeutics, Inc. insiders have bought stock, totalling 0 shares

How much of TNGX does insiders own?

Around 73.16M Tango Therapeutics, Inc. shares are held by insiders, which represents about 4.95% of TNGX stock.

Who is the insider with the largest stake?

TNGX 10 percent owner, Third Rock Ventures IV, L.P. holds the largest portfolio of the company's shares. TNGX shares owned by Third total nearly 13.39 million.

Which institution holds the most shares in TNGX?

CHARLES SCHWAB INVESTMENT MANAGEMENT INC is the largest institutional owner in TNGX which holds 840.99 thousand shares worth $7.45M or 0.76% of the total TNGX shares outstanding followed by BOOTHBAY FUND MANAGEMENT, LLC with ownership of 957.28 thousand shares representing 0.86% of the TNGX ownership. D. E. SHAW & CO., INC. is the third largest stakeholder with 1.03 million shares or 0.92% of the ownership worth more than $9.09M.

Is Tango Therapeutics, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the TNGX is concerned, it is a stock which is optionable.

Is there a short position on TNGX's shares?

Number of TNGX shares short is 25.40M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding TNGX shares are there?

As of today, 111.26M shares of TNGX are outstanding.

Is there many float in TNGX stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, TNGX has 37.40M shares in float.

TNGX short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for TNGX is 14.56.

Tango Therapeutics (TNGX) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares22.83

Short Percent Of Float27.39

Shares Outstanding111.26M

Shares Float37.40M

Shares Short25.40M

Short Ratio14.56

27.39%

Short % of Float

22.83%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

4.95% Percentage of Shares held by All Insiders

97.43% Percentage of Shares held by All Institutions

102.5% Percentage of Float held by Institutions

193

Number of Institutions Holding Shares

Institutional Ownership

About 97.43% of TNGX shares are held by financial institutions. CHARLES SCHWAB INVESTMENT MANAGEMENT INC is the top corporate investor, holding 840.99K shares valued at $7.45M. A 0.76% stake in Tango Therapeutics, Inc. is owned by the company. BOOTHBAY FUND MANAGEMENT, LLC owns 957.28K shares valued at $8.48M, which translates its holding of 0.86% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.76%	840.99K	7.45M	182.7K	+27.75%
Dec 31, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.86%	957.28K	8.48M	957.28K	+100.00%
Dec 31, 2025	D. E. SHAW & CO., INC.	0.92%	1.03M	9.09M	595.17K	+138.29%
Dec 31, 2025	RTW INVESTMENTS, LP	1.34%	1.49M	13.21M	1.49M	+100.00%
Dec 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	1.78%	1.97M	17.49M	-945.42K	-32.38%
Dec 31, 2025	JANUS HENDERSON GROUP PLC	2.38%	2.64M	23.47M	341.96K	+14.85%
Dec 31, 2025	SUVRETTA CAPITAL MANAGEMENT, LLC	2.4%	2.66M	23.59M	2.66M	+100.00%
Dec 31, 2025	FMR LLC	2.58%	2.87M	25.41M	2.86M	+44,524.15%
Dec 31, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	2.62%	2.91M	25.76M	2.91M	+100.00%
Dec 31, 2025	CALIGAN PARTNERS LP	3.36%	3.73M	33.05M	3.73M	+100.00%
Dec 31, 2025	BELLEVUE GROUP AG	3.54%	3.93M	34.8M	3.93M	+100.00%
Dec 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	4.76%	5.28M	46.77M	1.81M	+52.02%
Dec 31, 2025	NEXTECH INVEST, LTD.	6.55%	7.27M	64.38M	1.73M	+31.30%
Dec 31, 2025	JPMORGAN CHASE & CO	0.05%	56.84K	503.56K	22.92K	+67.58%
Dec 31, 2025	Y-INTERCEPT (HONG KONG) LTD	0.05%	59.33K	525.66K	22.37K	+60.51%
Dec 31, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.05%	59.69K	528.87K	11.97K	+25.07%
Dec 31, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.05%	60K	502K	0	0
Dec 31, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.06%	64.24K	512.02K	47.06K	+273.83%
Dec 31, 2025	TUDOR INVESTMENT CORP ET AL	0.06%	68.25K	604.7K	14.68K	+27.40%
Dec 31, 2025	AQR CAPITAL MANAGEMENT LLC	0.07%	82.23K	728.58K	3.06K	+3.86%
Dec 31, 2025	PROFUND ADVISORS LLC	0.08%	83.76K	742.11K	52.47K	+167.70%
Dec 31, 2025	SWISS NATIONAL BANK	0.08%	87.8K	777.91K	87.8K	+100.00%
Dec 31, 2025	GSA CAPITAL PARTNERS LLP	0.11%	118.59K	1.05M	118.59K	+100.00%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.11%	121.19K	1.07M	66.18K	+120.32%
Dec 31, 2025	VERITION FUND MANAGEMENT LLC	0.11%	121.78K	1.08M	97.03K	+392.00%
Dec 31, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.12%	129.48K	1.15M	129.48K	+100.00%
Dec 31, 2025	FRANKLIN RESOURCES INC	1.26%	1.4M	12.39M	471.15K	+50.83%
Dec 31, 2025	WOODLINE PARTNERS LP	9.08%	10.07M	89.24M	4.04M	+67.04%
Dec 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	9.56%	10.61M	93.99M	8.1M	+322.46%
Dec 31, 2025	TCG CROSSOVER MANAGEMENT, LLC	11.5%	12.76M	113.07M	4.23M	+49.51%
Dec 31, 2025	FARALLON CAPITAL MANAGEMENT LLC	11.77%	13.06M	115.72M	2.3M	+21.42%
Dec 31, 2025	BLACKROCK, INC.	7.7%	8.54M	75.67M	2.89M	+51.25%
Dec 31, 2025	TWO SIGMA INVESTMENTS, LP	0.13%	144.43K	1.28M	0	0
Dec 31, 2025	CITADEL ADVISORS LLC	0.14%	151.88K	1.35B	151.88K	+100.00%
Dec 31, 2025	SQUAREPOINT OPS LLC	0.16%	173.94K	1.54M	173.94K	+100.00%
Dec 31, 2025	FISHER ASSET MANAGEMENT, LLC	0.17%	187.69K	1.66M	-22.66K	-10.77%
Dec 31, 2025	CONGRESS ASSET MANAGEMENT CO /MA	0.21%	234.63K	2.08M	6.51K	+2.85%
Dec 31, 2025	MARSHALL WACE, LLP	0.3%	329.23K	2.92M	-1.16M	-77.90%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.31%	343.84K	3.05M	151.49K	+78.76%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	0.43%	478.06K	4.24M	322.62K	+207.54%
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	0.53%	593K	5.25M	-702.4K	-54.22%
Dec 31, 2025	BESSEMER GROUP INC	0.64%	708.4K	6.28M	0	0
Dec 31, 2025	UBS GROUP AG	0.89%	990.46K	8.78M	829.98K	+517.19%
Dec 31, 2025	LOGOS GLOBAL MANAGEMENT LP	3.78%	4.2M	37.21M	3.25M	+342.11%
Dec 31, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.35%	386.92K	3.43M	386.92K	+100.00%
Dec 31, 2025	TRV GP VI, LLC	0.17%	194.17K	1.72M	0	0
Dec 31, 2025	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	0.4%	446.21K	3.95M	-3.08M	-87.35%
Dec 31, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.2%	226.6K	2.01M	81.29K	+55.94%
Dec 31, 2025	GREAT LAKES ADVISORS, LLC	0.27%	294.3K	2.61M	-129.55K	-30.56%
Dec 31, 2025	NUVEEN, LLC	0.27%	300.44K	2.66M	-627.57K	-67.63%
Dec 31, 2025	MASS GENERAL BRIGHAM, INC	0.32%	354.19K	3.14B	354.19K	+100.00%
Dec 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.44%	487.08K	4.32M	-185.66K	-27.60%
Dec 31, 2025	CANDRIAM S.C.A.	0.64%	708.81K	6.28M	0	0
Dec 31, 2025	AFFINITY ASSET ADVISORS, LLC	0.9%	1M	8.86M	1M	+100.00%
Dec 31, 2025	VANGUARD GROUP INC	6.08%	6.75M	59.81M	1.7M	+33.63%
Dec 31, 2025	TRV GP IV, LLC	7.1%	7.87M	69.77M	-5.99M	-43.20%
Dec 31, 2025	SIREN, L.L.C.	7.36%	8.17M	72.35M	2.28M	+38.79%
Dec 31, 2025	BOXER CAPITAL MANAGEMENT, LLC	9.8%	10.88M	96.36M	1.1M	+11.31%
Dec 31, 2025	PERCEPTIVE ADVISORS LLC	0.46%	513.04K	4.55M	513.04K	+100.00%
Dec 31, 2025	SPHERA FUNDS MANAGEMENT LTD.	0.49%	544.56K	4.82M	544.56K	+100.00%
Dec 31, 2025	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	0.59%	653.49K	5.79M	-2.06M	-75.90%
Dec 31, 2025	STATE STREET CORP	5.6%	6.22M	55.1M	2.85M	+84.79%
Dec 31, 2025	ARROWMARK COLORADO HOLDINGS LLC	0.64%	708.39K	6.28M	0	0
Dec 31, 2025	NORTHERN TRUST CORP	0.72%	803.2K	7.12M	197.64K	+32.64%
Dec 31, 2025	LEGAL & GENERAL GROUP PLC	0.04%	39.43K	349.35K	32.99K	+511.79%
Dec 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.04%	41.45K	367.27K	41.45K	+100.00%
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.04%	41.8K	370.35K	-20K	-32.36%
Dec 31, 2025		0.04%	46.12K	408.65K	46.12K	+100.00%
Dec 31, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.04%	47.81K	423.61K	34.35K	+255.08%
Dec 31, 2025	SEI INVESTMENTS CO	0.05%	53.93K	477.77K	43.88K	+436.85%
Dec 31, 2025	DEUTSCHE BANK AG\	0.07%	74.2K	657.44K	15.05K	+25.45%
Dec 31, 2025	RHUMBLINE ADVISERS	0.12%	129.11K	1.14B	21.27K	+19.72%
Dec 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.29%	318.68K	2.82M	318.68K	+100.00%
Dec 31, 2025	BARCLAYS PLC	0.33%	368.19K	3.26M	2.51K	+0.69%
Dec 31, 2025	JANNEY MONTGOMERY SCOTT LLC	0.03%	36K	319K	0	0
Dec 31, 2025	CITIGROUP INC	0.03%	36.24K	321.05K	18.13K	+100.18%
Dec 31, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.04%	38.94K	345.02K	10.79K	+38.32%
Dec 31, 2025	MORGAN STANLEY	1.28%	1.42M	12.6M	1.17M	+464.67%
Dec 31, 2025	VIVO CAPITAL, LLC	1.94%	2.15M	19.09M	1.38M	+177.43%
Dec 31, 2025	DEEP TRACK CAPITAL, LP	2.21%	2.45M	21.75M	1M	+68.75%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.3%	2.55M	22.63M	670.88K	+35.63%
Dec 31, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	3.22%	3.57M	31.65M	1.76M	+97.39%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	4.45%	4.94M	43.79M	3.43M	+227.43%
Sep 30, 2025	CONGRESS ASSET MANAGEMENT CO /MA	0.21%	228.12K	1.92M	926	+0.41%
Sep 30, 2025	FRED ALGER MANAGEMENT, LLC	0.21%	230.32K	1.93M	38.98K	+20.37%
Sep 30, 2025	FISHER ASSET MANAGEMENT, LLC	0.19%	210.35K	1.77M	-13.73K	-6.13%
Sep 30, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.27%	300K	2.52M	-430K	-58.90%
Sep 30, 2025	MORGAN STANLEY	0.23%	251.79K	2.12M	-282.83K	-52.90%
Sep 30, 2025	ROYAL BANK OF CANADA	0.26%	287.5K	2.42M	35.23K	+13.96%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.23%	253.29K	2.13M	253.29K	+100.00%
Sep 30, 2025	STATE STREET CORP	3.04%	3.37M	28.27M	1.98M	+143.38%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	3.14%	3.47M	29.17M	224.74K	+6.92%
Sep 30, 2025	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	3.19%	3.53M	29.62M	357.13K	+11.27%
Sep 30, 2025	GILEAD SCIENCES, INC.	4.39%	4.85M	40.78M	0	0
Sep 30, 2025	VANGUARD GROUP INC	4.57%	5.05M	42.44M	1.03M	+25.46%
Sep 30, 2025	NEXTECH INVEST, LTD.	5.01%	5.53M	46.49M	0	0
Sep 30, 2025	BLACKROCK, INC.	5.11%	5.65M	47.43M	183.65K	+3.36%
Sep 30, 2025	SIREN, L.L.C.	5.32%	5.88M	49.42M	2.52M	+74.84%
Sep 30, 2025	WOODLINE PARTNERS LP	5.45%	6.03M	50.65M	22	0.00%
Sep 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	7.72%	8.54M	71.7M	-2.2M	-20.49%
Sep 30, 2025	BOXER CAPITAL MANAGEMENT, LLC	8.84%	9.77M	82.08M	0	0
Sep 30, 2025	ECOR1 CAPITAL, LLC	9.62%	10.63M	89.3M	0	0
Sep 30, 2025	FARALLON CAPITAL MANAGEMENT LLC	9.73%	10.76M	90.36M	1.6M	+17.47%
Sep 30, 2025	TRV GP IV, LLC	12.54%	13.86M	116.46M	-3M	-17.77%
Sep 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.01%	13.47K	113.11K	-7.83K	-36.77%
Sep 30, 2025	AXQ CAPITAL, LP	0.01%	13.47K	113.13K	13.47K	+100.00%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.01%	15.09K	126.76K	6.48K	+75.28%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.01%	15.58K	130.84K	9K	+136.86%
Sep 30, 2025	PROSHARE ADVISORS LLC	0.01%	16.23K	136.33K	-3.55K	-17.93%
Sep 30, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.02%	17.19K	144.35K	6.9K	+67.01%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.02%	18.07K	151.81K	18.07K	+100.00%
Sep 30, 2025	CITIGROUP INC	0.02%	18.1K	152.06K	-12.19K	-40.24%
Sep 30, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	19.5K	163.82K	-2.27K	-10.42%
Sep 30, 2025	VANGUARD PERSONALIZED INDEXING MANAGEMENT, LLC	0.02%	20.21K	169.79K	-156	-0.77%
Sep 30, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.02%	20.55K	172.6K	2.9K	+16.44%
Sep 30, 2025	EVERSOURCE WEALTH ADVISORS, LLC	0.02%	26.65K	223.89K	22	+0.08%
Sep 30, 2025	SIMPLICITY WEALTH,LLC	0.02%	26.96K	226.47K	0	0
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	28.15K	236.48K	-17.52K	-38.36%
Sep 30, 2025	CLEAR HARBOR ASSET MANAGEMENT, LLC	0.03%	30.3K	254.52K	1	0.00%
Sep 30, 2025	PROFUND ADVISORS LLC	0.03%	31.29K	262.82K	31.29K	+100.00%
Sep 30, 2025	JPMORGAN CHASE & CO	0.03%	33.92K	284.89K	-32.76K	-49.13%
Sep 30, 2025	JANNEY MONTGOMERY SCOTT LLC	0.03%	36K	302K	-3.5K	-8.86%
Sep 30, 2025	QUADRATURE CAPITAL LTD	0.03%	36.19K	303.26K	36.19K	+100.00%
Sep 30, 2025	Y-INTERCEPT (HONG KONG) LTD	0.03%	36.96K	310.49K	36.96K	+100.00%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	47.73K	400.9K	0	0
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.05%	55.01K	462.04K	5.79K	+11.76%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.05%	55.3K	464.52K	-10.2K	-15.57%
Sep 30, 2025	DEUTSCHE BANK AG\	0.05%	59.15K	496.85K	6.49K	+12.32%
Sep 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.05%	60K	497K	0	0
Sep 30, 2025	RHUMBLINE ADVISERS	0.1%	107.84K	905.84K	-4.43K	-3.95%
Sep 30, 2025	BLUE OWL CAPITAL HOLDINGS LP	0.11%	119.42K	1M	-695K	-85.34%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.13%	145.32K	1.22M	145.32K	+100.00%
Sep 30, 2025	UBS GROUP AG	0.15%	160.48K	1.35M	-116.62K	-42.09%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.17%	192.35K	1.62M	4.35K	+2.31%
Sep 30, 2025	BARCLAYS PLC	0.33%	365.68K	3.07M	227.03K	+163.74%
Sep 30, 2025	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.35%	384.21K	3.23M	384.21K	+100.00%
Sep 30, 2025	LOGOS GLOBAL MANAGEMENT LP	0.86%	950K	7.98M	950K	+100.00%
Sep 30, 2025	INVESCO LTD.	0.93%	1.03M	8.67M	936.62K	+982.89%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	1.17%	1.3M	10.88M	-476.9K	-26.91%
Sep 30, 2025	DEEP TRACK CAPITAL, LP	1.32%	1.45M	12.22M	1.45M	+100.00%
Sep 30, 2025	MARSHALL WACE, LLP	1.35%	1.49M	12.51M	-253.17K	-14.53%
Sep 30, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0.22%	240.66K	2.02M	240.66K	+100.00%
Sep 30, 2025	READYSTATE ASSET MANAGEMENT LP	0.22%	245.11K	2.06M	-173.41K	-41.43%
Sep 30, 2025	STEMPOINT CAPITAL LP	0.22%	245.38K	2.06M	36.58K	+17.52%
Sep 30, 2025	GREAT LAKES ADVISORS, LLC	0.38%	423.85K	3.56M	423.85K	+100.00%
Sep 30, 2025	D. E. SHAW & CO., INC.	0.39%	430.38K	3.62M	430.38K	+100.00%
Sep 30, 2025	AVORO CAPITAL ADVISORS LLC	0.49%	545K	4.58M	545K	+100.00%
Sep 30, 2025	NORTHERN TRUST CORP	0.55%	605.56K	5.09M	5.05K	+0.84%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.6%	658.29K	5.53M	56.85K	+9.45%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.61%	672.74K	5.65M	147.64K	+28.12%
Sep 30, 2025	ARROWMARK COLORADO HOLDINGS LLC	0.64%	708.39K	5.95M	0	0
Sep 30, 2025	BESSEMER GROUP INC	0.64%	708.4K	5.95M	14	0.00%
Sep 30, 2025	CANDRIAM S.C.A.	0.64%	708.81K	5.95M	0	0
Sep 30, 2025	VIVO CAPITAL, LLC	0.7%	776.7K	6.52M	176.7K	+29.45%
Sep 30, 2025	FRANKLIN RESOURCES INC	0.84%	926.9K	7.79M	801.7K	+640.30%
Sep 30, 2025	NUVEEN, LLC	0.84%	928.01K	7.8M	485.05K	+109.50%
Sep 30, 2025	COMMODORE CAPITAL LP	1.36%	1.5M	12.6M	0	0
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.37%	1.51M	12.68M	1.4M	+1,295.35%
Sep 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	1.64%	1.81M	15.2M	-1.63M	-47.38%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.7%	1.88M	15.82M	113.86K	+6.44%
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	1.81%	2M	16.8M	0	0
Sep 30, 2025	JANUS HENDERSON GROUP PLC	2.08%	2.3M	19.32M	2.3M	+100.00%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	2.27%	2.51M	21.09M	-3.39M	-57.48%
Sep 30, 2025	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	2.45%	2.71M	22.78M	0	0
Sep 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	2.64%	2.92M	24.52M	2.92M	+100.00%
Sep 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	2.79%	3.09M	25.92M	3.09M	+100.00%
Sep 30, 2025	TRV GP VI, LLC	0.18%	194.17K	1.63M	0	0
Sep 30, 2025	TREXQUANT INVESTMENT LP	0.18%	199.08K	1.67M	199.08K	+100.00%
Jun 30, 2025	STEMPOINT CAPITAL LP	0.19%	208.8K	1.07M	208.8K	+100.00%
Jun 30, 2025	WOODLINE PARTNERS LP	5.45%	6.03M	30.87M	5.52M	+1,091.24%
Jun 30, 2025	BLACKROCK, INC.	4.94%	5.46M	27.97M	1.43M	+35.50%
Jun 30, 2025	VANGUARD GROUP INC	3.64%	4.03M	20.62M	151.26K	+3.90%
Jun 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	3.11%	3.44M	17.61M	451.61K	+15.11%
Jun 30, 2025	SIREN, L.L.C.	3.04%	3.36M	17.23M	799.47K	+31.16%
Jun 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	2.94%	3.25M	16.63M	27.89K	+0.87%
Jun 30, 2025	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	2.45%	2.71M	13.89M	0	0
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	1.81%	2M	10.24M	2M	+100.00%
Jun 30, 2025	COMMODORE CAPITAL LP	1.36%	1.5M	7.68M	1.5M	+100.00%
Jun 30, 2025	BLUE OWL CAPITAL HOLDINGS LP	0.74%	814.42K	4.17M	-1.31M	-61.61%
Jun 30, 2025	CANDRIAM S.C.A.	0.64%	708.81K	3.63M	708.81K	+100.00%
Jun 30, 2025	BESSEMER GROUP INC	0.64%	708.38K	3.63M	0	0
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.54%	601.45K	3.08M	53.43K	+9.75%
Jun 30, 2025	NORTHERN TRUST CORP	0.54%	600.51K	3.07M	151.13K	+33.63%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.48%	525.1K	2.69M	-80.19K	-13.25%
Jun 30, 2025	READYSTATE ASSET MANAGEMENT LP	0.38%	418.52K	2.14M	418.52K	+100.00%
Jun 30, 2025	UBS GROUP AG	0.25%	277.1K	1.42M	123.77K	+80.72%
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.22%	242.45K	1.24M	175.83K	+263.95%
Jun 30, 2025	FISHER ASSET MANAGEMENT, LLC	0.2%	224.08K	1.15M	0	0
Jun 30, 2025	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.14%	159.84K	818.37K	-72.93K	-31.33%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	5.34%	5.91M	30.24M	5.91M	+100.00%
Jun 30, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.66%	730K	3.74M	730K	+100.00%
Jun 30, 2025	VIVO CAPITAL, LLC	0.54%	600K	3.07M	600K	+100.00%
Jun 30, 2025	ROYAL BANK OF CANADA	0.23%	252.27K	1.29M	250.85K	+17,653.20%
Jun 30, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	0.2%	218.78K	1.12M	-519.18K	-70.35%
Jun 30, 2025	SAMSARA BIOCAPITAL, LLC	0.19%	210K	1.08M	-420K	-66.67%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.17%	188K	962.55K	74.76K	+66.03%
Jun 30, 2025	FRANKLIN RESOURCES INC	0.11%	125.21K	641.06K	342	+0.27%
Jun 30, 2025	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.11%	125K	640K	0	0
Jun 30, 2025	GILEAD SCIENCES, INC.	4.39%	4.85M	24.85M	0	0
Jun 30, 2025	TRV GP IV, LLC	15.25%	16.86M	86.32M	0	0
Jun 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	9.71%	10.74M	54.97M	0	0
Jun 30, 2025	ECOR1 CAPITAL, LLC	9.62%	10.63M	54.43M	0	0
Jun 30, 2025	FARALLON CAPITAL MANAGEMENT LLC	8.28%	9.16M	46.88M	4.55M	+98.59%
Jun 30, 2025	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	2.87%	3.17M	16.23M	-143.22K	-4.32%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	1.6%	1.77M	9.07M	301.37K	+20.49%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.6%	1.77M	9.06M	385.48K	+27.86%
Jun 30, 2025	MARSHALL WACE, LLP	1.58%	1.74M	8.92M	-99.47K	-5.40%
Jun 30, 2025	STATE STREET CORP	1.25%	1.38M	7.08M	238.24K	+20.82%
Jun 30, 2025		0.18%	200K	1.02M	200K	+100.00%
Jun 30, 2025	BOXER CAPITAL MANAGEMENT, LLC	8.84%	9.77M	50.03M	-609.51K	-5.87%
Jun 30, 2025	NEXTECH INVEST, LTD.	5.01%	5.53M	28.33B	0	0
Jun 30, 2025	ARROWMARK COLORADO HOLDINGS LLC	0.64%	708.39K	3.63M	0	0
Jun 30, 2025	MORGAN STANLEY	0.48%	534.62K	2.74M	284.1K	+113.41%
Jun 30, 2025	NUVEEN, LLC	0.4%	442.96K	2.27M	240.78K	+119.09%
Jun 30, 2025	CONGRESS ASSET MANAGEMENT CO /MA	0.21%	227.19K	1.16M	-167	-0.07%
Jun 30, 2025	DIADEMA PARTNERS LP	0.18%	200K	1.02M	200K	+100.00%
Jun 30, 2025	TRV GP VI, LLC	0.18%	194.17K	994.17K	0	0
Jun 30, 2025	FRED ALGER MANAGEMENT, LLC	0.17%	191.34K	979.65K	191.34K	+100.00%
Jun 30, 2025	BARCLAYS PLC	0.13%	138.65K	710K	75.62K	+119.97%
Mar 31, 2025	NORTHERN TRUST CORP	0.41%	449.38K	615.65K	-63.7K	-12.41%
Mar 31, 2025	TRV GP IV, LLC	15.28%	16.86M	23.1M	0	0
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.16%	172.43K	236.23K	-314.46K	-64.58%
Mar 31, 2025	GRAHAM CAPITAL MANAGEMENT, L.P.	0.11%	116.5K	159.6K	81.69K	+234.73%
Mar 31, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.12%	129.11K	176.88K	58.66K	+83.26%
Mar 31, 2025	SIREN, L.L.C.	2.33%	2.57M	3.51M	-38.56K	-1.48%
Mar 31, 2025	VANGUARD GROUP INC	3.51%	3.88M	5.31M	-109.68K	-2.75%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.16%	174.5K	239.07K	153K	+711.63%
Mar 31, 2025	FISHER ASSET MANAGEMENT, LLC	0.2%	224.08K	306.99K	69.13K	+44.62%
Mar 31, 2025	MORGAN STANLEY	0.23%	250.52K	343.21K	-69.55K	-21.73%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.32%	351.49K	481.54K	79.26K	+29.11%
Mar 31, 2025	JANE STREET GROUP, LLC	0.32%	352.9K	483.47K	257.67K	+270.58%
Mar 31, 2025	BLUE OWL CAPITAL HOLDINGS LP	1.92%	2.12M	2.91M	389.5K	+22.49%
Mar 31, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.59%	655.16K	963.08K	0	0
Mar 31, 2025	MARSHALL WACE, LLP	1.67%	1.84M	2.52M	1.84M	+100.00%
Mar 31, 2025	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	2.46%	2.71M	3.72M	0	0
Mar 31, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	2.71%	2.99M	4.09M	183.57K	+6.55%
Mar 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	2.92%	3.22M	4.41M	-59.63K	-1.82%
Mar 31, 2025	GILEAD SCIENCES, INC.	4.4%	4.85M	6.65M	0	0
Mar 31, 2025		0.18%	202.18K	276.99K	202.18K	+100.00%
Mar 31, 2025	CASDIN CAPITAL, LLC	0.11%	125K	171.25K	-1.06M	-89.48%
Mar 31, 2025	BLACKROCK, INC.	3.66%	4.03M	5.52M	-346.49K	-7.91%
Mar 31, 2025	ARROWMARK COLORADO HOLDINGS LLC	0.64%	708.39K	970.49K	0	0
Mar 31, 2025	FARALLON CAPITAL MANAGEMENT LLC	4.18%	4.61M	6.32M	610.93K	+15.27%
Mar 31, 2025	TWO SIGMA ADVISERS, LP	0.09%	97K	132.89K	70.8K	+270.23%
Mar 31, 2025	CONGRESS ASSET MANAGEMENT CO /MA	0.21%	227.36K	311.49K	-628	-0.28%
Mar 31, 2025	FRANKLIN RESOURCES INC	0.11%	124.87K	171.06K	-1.69K	-1.33%
Mar 31, 2025	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	3%	3.31M	4.54M	-33.1K	-0.99%
Mar 31, 2025	TCG CROSSOVER MANAGEMENT, LLC	9.73%	10.74M	14.71M	0	0
Mar 31, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	0.67%	737.96K	1.01M	220.53K	+42.62%
Mar 31, 2025	ACADIAN ASSET MANAGEMENT LLC	0.88%	973.31K	1.33M	478.2K	+96.59%
Mar 31, 2025	SAMSARA BIOCAPITAL, LLC	0.57%	630K	863.1K	0	0
Mar 31, 2025	STATE STREET CORP	1.04%	1.14M	1.57M	-86.76K	-7.05%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.25%	1.38M	1.9M	-3.01K	-0.22%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	1.33%	1.47M	2.02M	1.22M	+489.21%
Mar 31, 2025	WALLEYE CAPITAL LLC	0.19%	211.8K	290.16K	-75.26K	-26.22%
Mar 31, 2025	BESSEMER GROUP INC	0.64%	708.38K	970K	0	0
Mar 31, 2025	CITADEL ADVISORS LLC	0.1%	106.5K	145.91K	-1.52M	-93.45%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.1%	113.23K	155.13K	10.21K	+9.91%
Mar 31, 2025	GSA CAPITAL PARTNERS LLP	0.22%	241.73K	331K	155.28K	+179.63%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.55%	605.29K	829.86K	-57.49K	-8.67%
Mar 31, 2025	ORBIMED ADVISORS LLC	0.5%	550K	753.5K	0	0
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.5%	548.01K	750.78K	34.59K	+6.74%
Mar 31, 2025	WOODLINE PARTNERS LP	0.46%	506.19K	693.48K	111.79K	+28.34%
Mar 31, 2025	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.11%	125K	171.25K	125K	+100.00%
Mar 31, 2025	AQR CAPITAL MANAGEMENT LLC	0.13%	142.11K	194.69K	142.11K	+100.00%
Mar 31, 2025	UBS GROUP AG	0.14%	153.34K	210.07K	-261.14K	-63.00%
Mar 31, 2025	XTX TOPCO LTD	0.15%	168.15K	230.36K	90.21K	+115.74%
Mar 31, 2025	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.21%	232.77K	318.89K	-114.51K	-32.97%
Mar 31, 2024	BARCLAYS PLC	0.19%	183.49K	1.46M	-18.41K	-9.12%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.39%	379.48K	3.01M	10.41K	+2.82%
Mar 31, 2024	ENSIGN PEAK ADVISORS, INC	0.52%	506.38K	4.02M	11.17K	+2.26%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.63%	613.7K	4.87M	164.49K	+36.62%
Mar 31, 2024	SAMSARA BIOCAPITAL, LLC	0.65%	630K	5M	0	0
Mar 31, 2024	BESSEMER GROUP INC	0.73%	708.38K	5.63M	0	0
Mar 31, 2024	ARROWMARK COLORADO HOLDINGS LLC	0.73%	708.39K	5.62M	0	0
Mar 31, 2024	BAKER BROS. ADVISORS LP	0.77%	750K	5.96M	0	0
Mar 31, 2024	CASDIN CAPITAL, LLC	1.22%	1.19M	9.44M	0	0
Mar 31, 2024	SOLEUS CAPITAL MANAGEMENT, L.P.	1.39%	1.35M	10.72M	503K	+59.38%
Mar 31, 2024	ARTAL GROUP S.A.	2.26%	2.19M	17.43M	2.19M	+100.00%
Mar 31, 2024	ADAGE CAPITAL PARTNERS GP, L.L.C.	2.36%	2.29M	18.22M	-1.11M	-32.52%
Mar 31, 2024	STATE STREET CORP	2.95%	2.87M	22.76M	1.89M	+192.78%
Mar 31, 2024	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	2.98%	2.89M	22.97M	0	0
Mar 31, 2024	VANGUARD GROUP INC	3.17%	3.08M	24.46M	101.67K	+3.41%
Mar 31, 2024	BLACKROCK INC.	3.97%	3.86M	30.66M	-87.91K	-2.23%
Mar 31, 2024	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	4.45%	4.32M	34.31M	4.03M	+1,407.37%
Mar 31, 2024	NEXTECH INVEST LTD.	5.69%	5.53M	43.94M	0	0
Mar 31, 2024	BOXER CAPITAL, LLC	8.43%	8.2M	65.1M	0	0
Mar 31, 2024	FMR LLC	9.76%	9.49M	75.36M	-295.7K	-3.02%
Mar 31, 2024	ECOR1 CAPITAL, LLC	13.71%	13.33M	105.85M	0	0
Mar 31, 2024	TRV GP IV, LLC	19.75%	19.2M	152.46M	-162.5K	-0.84%
Mar 31, 2024	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.58%	1.54M	12.23M	0	0
Mar 31, 2024	UBS GROUP AG	0.16%	158.23K	1.26M	158.23K	+100.00%
Mar 31, 2024	CITIGROUP INC	0.2%	191.43K	1.52M	183.27K	+2,245.13%
Mar 31, 2024	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.2%	196.38K	1.56M	15.79K	+8.74%
Mar 31, 2024	NORTHERN TRUST CORP	0.41%	401.13K	3.18M	-11.28K	-2.73%
Mar 31, 2024	CITADEL ADVISORS LLC	0.48%	466.12K	3.7M	264.3K	+130.96%
Mar 31, 2024	SOUTHPOINT CAPITAL ADVISORS LP	5.43%	5.28M	41.9M	0	0
Mar 31, 2024	NEW YORK STATE COMMON RETIREMENT FUND	0.02%	22.07K	175K	-22	-0.10%
Mar 31, 2024	FRANKLIN RESOURCES INC	0.02%	22.53K	178.88K	-1.55K	-6.45%
Mar 31, 2024	FISHMAN JAY A LTD/MI	0.02%	24K	190.56K	10K	+71.43%
Mar 31, 2024	CLEAR HARBOR ASSET MANAGEMENT, LLC	0.03%	25.5K	202.43K	4.3K	+20.26%
Mar 31, 2024	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	25.78K	204.69K	0	0
Mar 31, 2024	SIMPLICITY WEALTH,LLC	0.03%	26.96K	214.07K	26.96K	+100.00%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.03%	27.29K	216.71K	9.21K	+50.96%
Mar 31, 2024	INVESCO LTD.	0.03%	28.05K	222.75K	-439.2K	-94.00%
Mar 31, 2024	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.03%	28.96K	149.34K	7.13K	+32.64%
Mar 31, 2024	SG AMERICAS SECURITIES, LLC	0.03%	30.43K	242K	4.2K	+16.03%
Mar 31, 2024	EXCHANGE TRADED CONCEPTS, LLC	0.03%	31.35K	248.89K	14.87K	+90.28%
Mar 31, 2024	INTEGRITY WEALTH SOLUTIONS LLC	0.03%	33.2K	263.6K	0	0
Mar 31, 2024	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.04%	34.26K	272.04K	34.26K	+100.00%
Mar 31, 2024	PROFUND ADVISORS LLC	0.04%	34.3K	272.32M	34.3K	+100.00%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.04%	36.41K	289.07M	0	0
Mar 31, 2024	JANNEY MONTGOMERY SCOTT LLC	0.04%	40K	318K	0	0
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.04%	42.89K	340.56K	42.89K	+100.00%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.05%	47.96K	380.8K	11.32K	+30.90%
Mar 31, 2024	VICTORY CAPITAL MANAGEMENT INC	0.06%	58.18K	461.95K	-14.46K	-19.91%
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.06%	59.78K	474.64M	59.78K	+100.00%
Mar 31, 2024	DEKABANK DEUTSCHE GIROZENTRALE	0.06%	60K	462K	0	0
Mar 31, 2024	CREDIT SUISSE AG/	0.07%	65.36K	518.93K	3.6K	+5.82%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.07%	65.6K	521K	-55.4K	-45.79%
Mar 31, 2024	READYSTATE ASSET MANAGEMENT LP	0.17%	168.4K	1.34M	168.4K	+100.00%
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	0.23%	220.02K	1.75M	220.02K	+100.00%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	0.24%	235.66K	1.87M	175.74K	+293.32%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.32%	307.24K	2.44M	70.84K	+29.97%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.36%	348.34K	2.77M	-71.21K	-16.97%
Mar 31, 2024	MASS GENERAL BRIGHAM, INC	0.36%	354.19K	2.81M	354.19K	+100.00%
Mar 31, 2024	RHUMBLINE ADVISERS	0.07%	71.44K	567.2K	1.05K	+1.49%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.08%	78.48K	623.11K	8.07K	+11.46%
Mar 31, 2024	SWISS NATIONAL BANK	0.08%	80.2K	636.79K	0	0
Mar 31, 2024	STATE OF WISCONSIN INVESTMENT BOARD	0.08%	81.13K	644.19K	40.77K	+101.03%
Mar 31, 2024	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.09%	86.16K	684.12K	-28.2K	-24.66%
Mar 31, 2024	FISHER ASSET MANAGEMENT, LLC	0.1%	100.69K	799.49K	0	0
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.11%	108.04K	857.86K	48.25K	+80.69%
Mar 31, 2024	MARSHALL WACE, LLP	0.11%	109.27K	867.6K	109.27K	+100.00%
Mar 31, 2024	JPMORGAN CHASE & CO	0.13%	122.7K	974.21K	72.89K	+146.36%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.13%	126.25K	1M	-14.72K	-10.44%
Mar 31, 2024	WELLINGTON MANAGEMENT GROUP LLP	0.15%	141K	1.12M	-29.23K	-17.17%
Mar 31, 2024	AFFINITY ASSET ADVISORS, LLC	0.15%	150.27K	1.19M	-150K	-49.95%
Mar 31, 2024	MORGAN STANLEY	0.18%	179.52K	1.43M	36.11K	+25.18%
Mar 31, 2024	FEDERATED HERMES, INC.	0.07%	67.12K	532.89K	66.96K	+42,922.44%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	1.17%	1.13M	9M	36.43K	+3.32%
Dec 31, 2023	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.19%	180.6K	1.79M	161.18K	+829.91%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.46%	449.22K	4.45M	334.36K	+291.10%
Dec 31, 2023	INVESCO LTD.	0.48%	467.25K	4.63M	-307.49K	-39.69%
Dec 31, 2023	ENSIGN PEAK ADVISORS, INC	0.51%	495.21K	4.9M	0	0
Dec 31, 2023	SAMSARA BIOCAPITAL, LLC	0.65%	630K	6.24M	0	0
Dec 31, 2023	BESSEMER GROUP INC	0.73%	708.38K	7.01M	0	0
Dec 31, 2023	ARROWMARK COLORADO HOLDINGS LLC	0.73%	708.39K	7.01M	708.39K	+100.00%
Dec 31, 2023	BAKER BROS. ADVISORS LP	0.77%	750K	7.43M	0	0
Dec 31, 2023	SOLEUS CAPITAL MANAGEMENT, L.P.	0.87%	847.15K	8.39M	-1.08M	-56.08%
Dec 31, 2023	STATE STREET CORP	1.01%	978.94K	9.69M	25.06K	+2.63%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.13%	1.1M	10.86M	62.11K	+6.00%
Dec 31, 2023	PERCEPTIVE ADVISORS LLC	1.15%	1.11M	11.01M	-1.31M	-54.04%
Dec 31, 2023	CASDIN CAPITAL, LLC	1.22%	1.19M	11.76M	-119K	-9.10%
Dec 31, 2023	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.59%	1.54M	15.25M	746.27K	+94.02%
Dec 31, 2023	RTW INVESTMENTS, LP	2.03%	1.97M	19.47M	1.97M	+100.00%
Dec 31, 2023	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	2.98%	2.89M	28.64M	0	0
Dec 31, 2023	VANGUARD GROUP INC	3.07%	2.98M	29.49M	39.37K	+1.34%
Dec 31, 2023	ADAGE CAPITAL PARTNERS GP, L.L.C.	3.5%	3.4M	33.66M	1.65M	+93.75%
Dec 31, 2023	BLACKROCK INC.	4.07%	3.95M	39.1M	391.76K	+11.01%
Dec 31, 2023	SOUTHPOINT CAPITAL ADVISORS LP	5.44%	5.28M	52.24M	0	0
Dec 31, 2023	NEXTECH INVEST LTD.	5.7%	5.53M	54.79M	0	0
Dec 31, 2023	BOXER CAPITAL, LLC	8.45%	8.2M	81.17M	1.08M	+15.09%
Dec 31, 2023	FMR LLC	10.09%	9.79M	96.89M	-1.86M	-15.96%
Dec 31, 2023	ECOR1 CAPITAL, LLC	13.74%	13.33M	131.97M	4.61M	+52.85%
Dec 31, 2023	TRV GP IV, LLC	19.96%	19.36M	191.7M	0	0
Dec 31, 2023	CREDIT SUISSE AG/	0.06%	61.76K	611.44K	-981	-1.56%
Dec 31, 2023	PARKMAN HEALTHCARE PARTNERS LLC	0.07%	65.68K	650.22K	-70.24K	-51.68%
Dec 31, 2023	RHUMBLINE ADVISERS	0.07%	70.39K	696.86K	624	+0.89%
Dec 31, 2023	AMERICAN CENTURY COMPANIES INC	0.07%	70.41K	697.05K	46.69K	+196.86%
Dec 31, 2023	VICTORY CAPITAL MANAGEMENT INC	0.07%	72.64K	719.14K	72.64K	+100.00%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.38%	369.07K	3.65M	1.71K	+0.47%
Dec 31, 2023	AFFINITY ASSET ADVISORS, LLC	0.31%	300.27K	2.97M	-49.73K	-14.21%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	0.3%	294.56K	2.92M	294.56K	+100.00%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.43%	419.55K	4.15M	238.08K	+131.19%
Dec 31, 2023	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	0.3%	286.69K	2.84M	286.69K	+100.00%
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	0.24%	236.39K	2.34M	104.3K	+78.96%
Dec 31, 2023	SWISS NATIONAL BANK	0.08%	80.2K	793.98K	-19.3K	-19.40%
Dec 31, 2023	JANE STREET GROUP, LLC	0.09%	86.22K	853.62K	86.22K	+100.00%
Dec 31, 2023	SQUAREPOINT OPS LLC	0.1%	99.81K	988.1K	99.81K	+100.00%
Dec 31, 2023	FISHER ASSET MANAGEMENT, LLC	0.1%	100.69K	996.84K	100.69K	+100.00%
Dec 31, 2023	CUBIST SYSTEMATIC STRATEGIES, LLC	0.1%	101.33K	1M	101.33K	+100.00%
Dec 31, 2023	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.12%	114.36K	1.13M	114.36K	+100.00%
Dec 31, 2023	RENAISSANCE TECHNOLOGIES LLC	0.12%	121K	1.2M	82.8K	+216.75%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.15%	140.97K	1.4M	-13.71K	-8.86%
Dec 31, 2023	MORGAN STANLEY	0.15%	143.41K	1.42M	-49.92K	-25.82%
Dec 31, 2023	WELLINGTON MANAGEMENT GROUP LLP	0.18%	170.23K	1.69M	170.23K	+100.00%
Dec 31, 2023	BARCLAYS PLC	0.21%	201.9K	2M	114.02K	+129.74%
Dec 31, 2023	CITADEL ADVISORS LLC	0.21%	201.82K	2M	201.82K	+100.00%
Dec 31, 2023	NORTHERN TRUST CORP	0.43%	412.4K	4.08M	10.96K	+2.73%
Dec 31, 2023	TANG CAPITAL MANAGEMENT LLC	0.21%	200K	1.98M	0	0

Insiders

Among the TNGX insiders holding of 4.95% of the stake in company, THIRD ROCK VENTURES IV, L.P., 10 percent owner, holds the largest shares of 13.39M. BOXER CAPITAL, LLC, , is the second largest TNGX insider with ownership of 8.2M shares. DAVIS AARON I., director, stands third with possession of 7.12M shares of that stake.

Insiders	Designation	Shares Held
THIRD ROCK VENTURES IV, L.P.	10 percent owner	13.39M
BOXER CAPITAL, LLC		8.2M
DAVIS AARON I.	director	7.12M
LEWIS JOSEPH	director	7.05M
BCTG HOLDINGS, LLC	10 percent owner	4.49M
BOXER CAPITAL MANAGEMENT, LLC	See remarks	3.61M
WEBER BARBARA	Director, Executive Chair	1.63M
CRYSTAL ADAM	President, R&D	187.22K
BECKMAN DANIELLA	Chief Financial Officer	184.3K
MVA INVESTORS, LLC	See remarks	108.79K
BARRY DOUGLAS	General Counsel	66.01K
ROTHENBERG MACE	director	31.25K
CALHOUN LESLEY ANN	director	6.25K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Feb 03, 2026	WEBER BARBARA	SALE	12.90	333	4.29K	1.63M
Feb 03, 2026	CRYSTAL ADAM	SALE	12.90	201	2.59K	187.22K
Feb 03, 2026	BECKMAN DANIELLA	SALE	12.90	113	1.46K	184.3K
Oct 23, 2025	THIRD ROCK VENTURES IV, L.P.	SALE	10.15	477.4K	4.85M	13.39M
Sep 25, 2025	THIRD ROCK VENTURES IV, L.P.	SALE	8.02	500K	4.01M	13.86M
Sep 16, 2025	THIRD ROCK VENTURES IV, L.P.	SALE	7.04	363.54K	2.56M	14.36M
Sep 08, 2025	THIRD ROCK VENTURES IV, L.P.	SALE	7.04	86.46K	608.63K	14.73M
Sep 05, 2025	THIRD ROCK VENTURES IV, L.P.	SALE	7.00	642.91K	4.5M	14.81M
Aug 22, 2025	THIRD ROCK VENTURES IV, L.P.	SALE	7.00	302.19K	2.12M	15.46M
Aug 19, 2025	THIRD ROCK VENTURES IV, L.P.	SALE	7.01	1.1M	7.71M	15.76M
Feb 05, 2025	CRYSTAL ADAM	SALE	3.16	6.85K	21.66K	158.21K
Feb 05, 2025	BARRY DOUGLAS	SALE	3.16	2.56K	8.08K	66.01K
Feb 05, 2025	WEBER BARBARA	SALE	3.16	9.01K	28.49K	1.62M
Feb 05, 2025	BECKMAN DANIELLA	SALE	3.16	3.95K	12.48K	150.28K
Feb 04, 2025	CRYSTAL ADAM	SALE	2.99	7.43K	22.21K	165.06K
Feb 04, 2025	BECKMAN DANIELLA	SALE	2.99	4.28K	12.8K	154.23K
Feb 04, 2025	BARRY DOUGLAS	SALE	2.99	2.77K	8.29K	68.57K
Feb 04, 2025	WEBER BARBARA	SALE	2.99	9.78K	29.22K	1.63M
Nov 18, 2024	ROTHENBERG MACE	PURCHASE	3.78	10K	37.8K	31.25K
Nov 14, 2024	ROTHENBERG MACE	PURCHASE	3.62	10K	36.2K	21.25K
Nov 06, 2024	BOXER CAPITAL MANAGEMENT, LLC	SALE	3.14	3.08M	9.67M	3.61M
Oct 25, 2024	BOXER CAPITAL MANAGEMENT, LLC	SALE	6.87	633K	4.35M	6.69M
Oct 22, 2024	BOXER CAPITAL MANAGEMENT, LLC	SALE	6.78	250K	1.7M	7.32M
Oct 21, 2024	BOXER CAPITAL MANAGEMENT, LLC	SALE	7.05	625K	4.41M	7.57M
Sep 13, 2024	THIRD ROCK VENTURES IV, L.P.	SALE	10.53	67.4K	709.76K	16.86M
Sep 05, 2024	THIRD ROCK VENTURES IV, L.P.	SALE	11.56	75K	867.14K	16.93M
Aug 30, 2024	THIRD ROCK VENTURES IV, L.P.	SALE	11.60	175K	2.03M	17M
Aug 27, 2024	THIRD ROCK VENTURES IV, L.P.	SALE	11.55	25K	288.67K	17.18M
Aug 19, 2024	THIRD ROCK VENTURES IV, L.P.	SALE	10.09	150K	1.51M	17.2M
Aug 16, 2024	THIRD ROCK VENTURES IV, L.P.	SALE	9.79	135K	1.32M	17.35M
Aug 01, 2024	THIRD ROCK VENTURES IV, L.P.	SALE	9.80	40K	392K	17.49M
Jul 31, 2024	THIRD ROCK VENTURES IV, L.P.	SALE	9.93	100K	993.38K	17.53M
Jul 30, 2024	THIRD ROCK VENTURES IV, L.P.	SALE	9.80	95K	931.11K	17.63M
Jul 26, 2024	THIRD ROCK VENTURES IV, L.P.	SALE	9.84	50K	491.95K	17.72M
Jul 25, 2024	THIRD ROCK VENTURES IV, L.P.	SALE	9.87	100.6K	992.77K	17.77M
Jul 24, 2024	THIRD ROCK VENTURES IV, L.P.	SALE	9.82	200K	1.96M	17.87M
Jul 23, 2024	THIRD ROCK VENTURES IV, L.P.	SALE	9.79	125K	1.22M	18.07M
Jul 22, 2024	THIRD ROCK VENTURES IV, L.P.	SALE	9.78	262.74K	2.57M	18.2M
Jul 18, 2024	THIRD ROCK VENTURES IV, L.P.	SALE	9.81	191.49K	1.88M	18.46M
Jul 17, 2024	THIRD ROCK VENTURES IV, L.P.	SALE	9.79	550.17K	5.39M	18.65M
Jul 02, 2024	MVA INVESTORS, LLC	SALE	8.68	95K	824.6K	108.79K
Jul 01, 2024	MVA INVESTORS, LLC	SALE	8.87	110.73K	982.18K	203.79K
Jun 28, 2024	MVA INVESTORS, LLC	SALE	8.57	29K	248.53K	314.52K
Jun 07, 2024	MVA INVESTORS, LLC	SALE	6.88	77K	529.76K	343.52K
Jun 06, 2024	MVA INVESTORS, LLC	SALE	7.24	63K	456.12K	420.52K
Jun 05, 2024	CALHOUN LESLEY ANN	SALE	7.21	5K	36.04K	6.25K
May 03, 2024	MVA INVESTORS, LLC	SALE	7.61	60K	456.6K	483.52K
May 02, 2024	MVA INVESTORS, LLC	SALE	7.56	75K	567K	543.52K
May 01, 2024	MVA INVESTORS, LLC	SALE	7.43	75K	557.25K	618.52K
Feb 20, 2024	THIRD ROCK VENTURES IV, L.P.	SALE	12.00	162.5K	1.95M	19.2M
Feb 07, 2024	BARRY DOUGLAS	SALE	12.62	1.35K	17.09K	43.98K
Feb 07, 2024	BECKMAN DANIELLA	SALE	12.62	1.82K	22.93K	132.4K
Feb 07, 2024	CRYSTAL ADAM	SALE	12.62	4.08K	51.53K	119.48K
Feb 07, 2024	WEBER BARBARA	SALE	12.62	4.46K	56.25K	1.54M
Feb 06, 2024	WEBER BARBARA	SALE	12.56	4.68K	58.81K	1.54M
Feb 06, 2024	CRYSTAL ADAM	SALE	12.56	4.29K	53.87K	123.56K
Feb 06, 2024	BECKMAN DANIELLA	SALE	12.56	1.91K	23.97K	134.21K
Feb 06, 2024	BARRY DOUGLAS	SALE	12.56	1.42K	17.86K	45.34K
Nov 01, 2023	CRYSTAL ADAM	SALE	8.39	7.51K	62.99K	81.25K
Oct 16, 2023	BOXER CAPITAL, LLC	PURCHASE	6.84	500K	3.42M	8.2M
Oct 13, 2023	BOXER CAPITAL, LLC	PURCHASE	7.07	750K	5.3M	7.7M
Oct 09, 2023	BOXER CAPITAL, LLC	SALE	9.91	50K	495.5K	693.52K
Aug 11, 2023	BOXER CAPITAL, LLC	PURCHASE	5.15	475K	2.45M	743.54K
Oct 13, 2022	DAVIS AARON I.	PURCHASE	4.65	70K	325.23K	7.12M
Oct 13, 2022	BOXER CAPITAL, LLC	PURCHASE	4.65	70K	325.23K	7.12M
Oct 12, 2022	DAVIS AARON I.	PURCHASE	4.43	50K	221.64K	268.52K
Oct 12, 2022	BOXER CAPITAL, LLC	PURCHASE	4.43	50K	221.64K	268.52K
Oct 11, 2022	BOXER CAPITAL, LLC	PURCHASE	4.25	117K	497.71K	218.52K
Oct 11, 2022	DAVIS AARON I.	PURCHASE	4.25	117K	497.71K	218.52K
Oct 06, 2022	BOXER CAPITAL, LLC	PURCHASE	4.06	70.39K	286.07K	7.05M
Oct 06, 2022	LEWIS JOSEPH	PURCHASE	4.06	70.39K	286.07K	7.05M
Oct 05, 2022	BOXER CAPITAL, LLC	PURCHASE	3.93	45.5K	178.64K	6.94M
Oct 05, 2022	LEWIS JOSEPH	PURCHASE	3.93	45.5K	178.64K	6.94M
Oct 04, 2022	BOXER CAPITAL, LLC	PURCHASE	3.67	25.61K	93.98K	6.9M
Oct 04, 2022	LEWIS JOSEPH	PURCHASE	3.67	25.61K	93.98K	6.9M
Nov 20, 2020	BCTG HOLDINGS, LLC	SALE	0.01	2.5K	15	4.49M
Sep 08, 2020	BCTG HOLDINGS, LLC	PURCHASE	10.00	533.5K	5.34M	4.49M

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES2.07M8

NET SHARES-2.07M8

SHARES HELD73.16M8

% NET SHARES-102.83%0%

Frequently Asked Questions