How many institutions own THRD stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own THRD shares is 134, representing 80.12% of the company's common stock.

Who are the major shareholders selling Third Harmonic Bio, Inc. stock?

MILLENNIUM MANAGEMENT LLC, in the last quarter, reduced its stake in THRD by -100% restricting it's holding to 0 shares of worth nearly -. AQR CAPITAL MANAGEMENT LLC also lessened -100% of the THRD shares from its portfolio, reducing its holding to 0 shares of worth -. CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM also shunned THRD shares holding by -100% last quarter which brought its holding to 0 shares worth -.

Investors who are buying THRD stock?

As per its latest 13F filing, GAMMA INVESTING LLC increased its stake in THRD by 336.19% in the last quarter. The institutional holder raised its holding to 458 shares having worth more than $2.46K. CHARLES SCHWAB INVESTMENT MANAGEMENT INC also added 4.87% more shares of THRD to its portfolio, raising its holding to 185.8 thousand shares of worth $1.01M. PDT PARTNERS, LLC also increased its THRD shares holding by 100% which brought its holding to 30.12 thousand shares worth $163.54K.

THRD's major insiders: who are they?

The insider with the most stakes in THRD is Atlas Venture Fund XI, L.P. , 10 percent owner at the company. Additionally, THRD stock is highly held by ORBIMED ADVISORS LLC and Bonita David P among others.

Did an insider recently sell THRD stock?

Company executives, directors, and other insiders own 9.11% percent of Third Harmonic Bio, Inc.'s stock. Within the last six months, there have been 0 transaction(s) in which THRD insiders have sold stock, totaling 0 shares. Insiders that have sold shares include CONNER EDWARD R., BVF PARTNERS L P/IL, and PERSON JULIE.

Which insider recently purchased THRD stock?

There have been 0 transaction(s) during the past 6-months in which Third Harmonic Bio, Inc. insiders have bought stock, totalling 0 shares

How much of THRD does insiders own?

Around 0 Third Harmonic Bio, Inc. shares are held by insiders, which represents about 9.11% of THRD stock.

Who is the insider with the largest stake?

THRD 10 percent owner, Atlas Venture Fund XI, L.P. holds the largest portfolio of the company's shares. THRD shares owned by Atlas total nearly 10.31 million.

Which institution holds the most shares in THRD?

MILLENNIUM MANAGEMENT LLC is the largest institutional owner in THRD which holds 0 shares worth - or 0% of the total THRD shares outstanding followed by AQR CAPITAL MANAGEMENT LLC with ownership of 0 shares representing 0% of the THRD ownership. CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM is the third largest stakeholder with 0 shares or 0% of the ownership worth more than -.

Is Third Harmonic Bio, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the THRD is concerned, it is a stock which is optionable.

Is there a short position on THRD's shares?

Number of THRD shares short is 1.42M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding THRD shares are there?

As of today, 45.13M shares of THRD are outstanding.

Is there many float in THRD stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, THRD has 15.60M shares in float.

THRD short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for THRD is 6.95.

Third Harmonic Bio (THRD) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableNo

OptionableYes

Short Percent Of Outstanding Shares3.15

Short Percent Of Float5.17

Shares Outstanding45.13M

Shares Float15.60M

Shares Short1.42M

Short Ratio6.95

5.17%

Short % of Float

3.15%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

9.11% Percentage of Shares held by All Insiders

80.12% Percentage of Shares held by All Institutions

88.15% Percentage of Float held by Institutions

134

Number of Institutions Holding Shares

Institutional Ownership

About 80.12% of THRD shares are held by financial institutions. MILLENNIUM MANAGEMENT LLC is the top corporate investor, holding 0 shares valued at -. A 0% stake in Third Harmonic Bio, Inc. is owned by the company. AQR CAPITAL MANAGEMENT LLC owns 0 shares valued at -, which translates its holding of 0% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0%	0	-	-59.36K	-100.00%
Sep 30, 2025	AQR CAPITAL MANAGEMENT LLC	0%	0	-	-73.65K	-100.00%
Sep 30, 2025	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0%	0	-	-1.44K	-100.00%
Sep 30, 2025	ORBIMED ADVISORS LLC	0%	0	-	-5.78M	-100.00%
Sep 30, 2025	OMERS ADMINISTRATION CORP	0%	0	-	-426.9K	-100.00%
Sep 30, 2025	NISA INVESTMENT ADVISORS, LLC	0%	0	-	-3.42K	-100.00%
Sep 30, 2025	MORGAN STANLEY	0%	0	-	-272.47K	-100.00%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	0%	0	-	-221.09K	-100.00%
Sep 30, 2025	TRUE WEALTH DESIGN, LLC	0%	0	-	-211	-100.00%
Sep 30, 2025	FORTITUDE FAMILY OFFICE, LLC	0%	0	-	-97	-100.00%
Sep 30, 2025	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	0%	0	-	-10.4M	-100.00%
Sep 30, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0%	0	-	-9.06K	-100.00%
Sep 30, 2025	QUEST PARTNERS LLC	0%	0	-	-11.87K	-100.00%
Sep 30, 2025	FIFTH LANE CAPITAL, LP	0%	0	-	-50K	-100.00%
Sep 30, 2025	RISE ADVISORS, LLC	0%	0	-	-144	-100.00%
Sep 30, 2025	PHYSICIAN WEALTH ADVISORS, INC.	0%	0	-	-195	-100.00%
Sep 30, 2025	AFFINITY ASSET ADVISORS, LLC	0%	0	-	-370K	-100.00%
Sep 30, 2025	VERSANT CAPITAL MANAGEMENT, INC	0%	0	-	-1.6K	-100.00%
Sep 30, 2025	EVERSOURCE WEALTH ADVISORS, LLC	0%	0	-	-50	-100.00%
Sep 30, 2025	PERISCOPE CAPITAL INC.	0%	0	-	-20K	-100.00%
Sep 30, 2025	BML CAPITAL MANAGEMENT, LLC	0%	0	-	-3.82M	-100.00%
Sep 30, 2025	UBS GROUP AG	0%	0	-	-52.26K	-100.00%
Sep 30, 2025	YAKIRA CAPITAL MANAGEMENT, INC.	0%	0	-	-293.63K	-100.00%
Sep 30, 2025	DLD ASSET MANAGEMENT, LP	0%	0	-	-503.84K	-100.00%
Sep 30, 2025	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0%	0	-	-1.74K	-100.00%
Sep 30, 2025	CWM, LLC	0%	0	-	-4.9K	-100.00%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0%	0	-	-15.58K	-100.00%
Sep 30, 2025	D. E. SHAW & CO., INC.	0%	0	-	-1.25M	-100.00%
Sep 30, 2025	ROYAL BANK OF CANADA	0%	0	-	-15.7K	-100.00%
Sep 30, 2025	DEUTSCHE BANK AG\	0%	0	-	-19.82K	-100.00%
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0%	0	-	-58.83K	-100.00%
Sep 30, 2025	NORTHERN TRUST CORP	0%	0	-	-197.55K	-100.00%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0%	0	-	-16.12K	-100.00%
Sep 30, 2025	PRELUDE CAPITAL MANAGEMENT, LLC	0%	0	-	-76.82K	-100.00%
Sep 30, 2025	ALLIANCEBERNSTEIN L.P.	0%	0	-	-20.83K	-100.00%
Sep 30, 2025	CSS LLC/IL	0%	0	-	-10K	-100.00%
Sep 30, 2025	ATWOOD & PALMER INC	0%	0	-	-1.5K	-100.00%
Sep 30, 2025	MARTINGALE ASSET MANAGEMENT L P	0%	0	-	-51.11K	-100.00%
Sep 30, 2025	GABELLI & CO INVESTMENT ADVISERS, INC.	0%	0	-	-251.68K	-100.00%
Sep 30, 2025	GROUP ONE TRADING, L.P.	0%	0	-	-100	-100.00%
Sep 30, 2025	FARALLON CAPITAL MANAGEMENT LLC	0%	0	-	-15.36K	-100.00%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0%	0	-	-75.66K	-100.00%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0%	0	-	-53.36K	-100.00%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0%	0	-	-185.8K	-100.00%
Sep 30, 2025	HSBC HOLDINGS PLC	0%	0	-	-27.76K	-100.00%
Sep 30, 2025	STRS OHIO	0%	0	-	-42.4K	-100.00%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0%	0	-	-5.98K	-100.00%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0%	0	-	-34.23K	-100.00%
Sep 30, 2025	JPMORGAN CHASE & CO	0%	0	-	-95.54K	-100.00%
Sep 30, 2025	SBI SECURITIES CO., LTD.	0%	20	1	0	0
Sep 30, 2025	GAMMA INVESTING LLC	0%	458	2.46K	353	+336.19%
Sep 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	0%	0	-	-2.94M	-100.00%
Sep 30, 2025	ALBERTA INVESTMENT MANAGEMENT CORP	0%	0	-	-239.39K	-100.00%
Sep 30, 2025	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0%	0	-	-31.79K	-100.00%
Sep 30, 2025	683 CAPITAL MANAGEMENT, LLC	0%	0	-	-200K	-100.00%
Sep 30, 2025	TAKEDA PHARMACEUTICAL CO LTD	0%	0	-	-36.84K	-100.00%
Sep 30, 2025	GRAHAM CAPITAL MANAGEMENT, L.P.	0%	0	-	-17.11K	-100.00%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	0%	0	-	-577.19K	-100.00%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0%	0	-	-73.53K	-100.00%
Sep 30, 2025	MEEDER ASSET MANAGEMENT INC	0%	0	-	-2.08K	-100.00%
Sep 30, 2025	CITIGROUP INC	0%	0	-	-14.22K	-100.00%
Sep 30, 2025	AMALGAMATED BANK	0%	665	4K	0	0
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0%	0	-	-2.32K	-100.00%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0%	0	-	-34.3K	-100.00%
Sep 30, 2025	PNC FINANCIAL SERVICES GROUP, INC.	0%	0	-	-1.33K	-100.00%
Sep 30, 2025	FMR LLC	0%	0	-	-4.41K	-100.00%
Sep 30, 2025	BARCLAYS PLC	0%	0	-	-56.91K	-100.00%
Sep 30, 2025	VANGUARD GROUP INC	0%	0	-	-1.3M	-100.00%
Sep 30, 2025	STATE STREET CORP	0%	0	-	-468.99K	-100.00%
Sep 30, 2025	ROTHSCHILD INVESTMENT LLC	0%	0	-	-255	-100.00%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0%	0	-	-11.81K	-100.00%
Sep 30, 2025	STERLING CAPITAL MANAGEMENT LLC	0%	0	-	-625	-100.00%
Sep 30, 2025	TANG CAPITAL MANAGEMENT LLC	0%	0	-	-929.73K	-100.00%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.21%	93.94K	510.09K	0	0
Jun 30, 2025	JPMORGAN CHASE & CO	0.21%	95.54K	518.77K	-168.88K	-63.87%
Jun 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.22%	97.02K	526.84K	-62.35K	-39.12%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.41%	185.8K	1.01M	8.63K	+4.87%
Jun 30, 2025	PDT PARTNERS, LLC	0.07%	30.12K	163.54K	30.12K	+100.00%
Jun 30, 2025	CSS LLC/IL	0.02%	7K	38.01K	7K	+100.00%
Jun 30, 2025	QUEST PARTNERS LLC	0.03%	11.87K	64.47K	0	0
Jun 30, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0.03%	13.21K	71.75K	1.36K	+11.47%
Jun 30, 2025	FARALLON CAPITAL MANAGEMENT LLC	0.03%	15.36K	83.41K	15.36K	+100.00%
Jun 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	15.58K	84.59K	4.41K	+39.51%
Jun 30, 2025	ROYAL BANK OF CANADA	0.04%	15.7K	85K	12.77K	+436.72%
Jun 30, 2025	ORBIMED ADVISORS LLC	12.87%	5.78M	31.38M	0	0
Jun 30, 2025	PERISCOPE CAPITAL INC.	0.04%	20K	108.6K	20K	+100.00%
Jun 30, 2025	TANG CAPITAL MANAGEMENT LLC	2.07%	929.73K	5.05M	0	0
Jun 30, 2025	LMR PARTNERS LLP	0.45%	200K	1.09M	200K	+100.00%
Jun 30, 2025	FNY INVESTMENT ADVISERS, LLC	0.22%	100.1K	543K	9.05K	+9.94%
Jun 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.16%	73.53K	399.25K	-36.08K	-32.92%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.13%	59.36K	322.33K	7.83K	+15.20%
Jun 30, 2025	BARCLAYS PLC	0.13%	56.91K	309K	21.87K	+62.44%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.12%	53.36K	289.73K	7.44K	+16.20%
Jun 30, 2025	MARTINGALE ASSET MANAGEMENT L P	0.11%	51.11K	277.54K	51.11K	+100.00%
Jun 30, 2025	FIFTH LANE CAPITAL, LP	0.11%	50K	271.5K	50K	+100.00%
Jun 30, 2025	STRS OHIO	0.09%	42.4K	230.23K	3K	+7.61%
Jun 30, 2025	TAKEDA PHARMACEUTICAL CO LTD	0.08%	36.84K	200.01K	0	0
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.08%	34.23K	185.87K	-50.46K	-59.58%
Jun 30, 2025	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	23.16%	10.4M	56.48M	0	0
Jun 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	4.26%	1.92M	10.4M	-590K	-23.55%
Jun 30, 2025	GRAHAM CAPITAL MANAGEMENT, L.P.	0.04%	17.11K	92.92K	17.11K	+100.00%
Jun 30, 2025	XTX TOPCO LTD	0.03%	14.7K	79.84K	14.7K	+100.00%
Jun 30, 2025	POINT72 (DIFC) LTD	0%	890	4.83K	808	+985.37%
Jun 30, 2025	STERLING CAPITAL MANAGEMENT LLC	0%	625	3.39K	247	+65.34%
Jun 30, 2025	ROTHSCHILD INVESTMENT LLC	0%	255	1.39K	150	+142.86%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.05%	20.83K	113.11M	8.9K	+74.60%
Jun 30, 2025	BLACKROCK, INC.	3.84%	1.73M	9.38M	247K	+16.69%
Jun 30, 2025	TWO SIGMA INVESTMENTS, LP	0.13%	58.83K	319.44K	10.8K	+22.49%
Jun 30, 2025	SQUAREPOINT OPS LLC	0.11%	51.1K	277.47K	-70.83K	-58.09%
Jun 30, 2025	WALLEYE CAPITAL LLC	0.05%	24.28K	131.81K	-77.98K	-76.26%
Jun 30, 2025	RANGELEY CAPITAL, LLC	0.65%	290K	1.57M	20K	+7.41%
Jun 30, 2025	OCCUDO QUANTITATIVE STRATEGIES LP	0.06%	26.99K	146.58K	26.99K	+100.00%
Jun 30, 2025		0.65%	290K	1.57M	20K	+7.41%
Jun 30, 2025	ATWOOD & PALMER INC	0%	1.5K	8.15K	0	0
Jun 30, 2025	VERSANT CAPITAL MANAGEMENT, INC	0%	1.6K	8.66K	1.6K	+100.00%
Jun 30, 2025	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0%	1.74K	9.47K	235	+15.58%
Jun 30, 2025	NORTHERN TRUST CORP	0.44%	197.55K	1.07M	-3.9K	-1.94%
Jun 30, 2025	683 CAPITAL MANAGEMENT, LLC	0.45%	200K	1.09M	0	0
Jun 30, 2025	VAZIRANI ASSET MANAGEMENT LLC	0.5%	225.5K	1.22M	142.05K	+170.22%
Jun 30, 2025	GABELLI & CO INVESTMENT ADVISERS, INC.	0.56%	251.68K	1.37M	251.68K	+100.00%
Jun 30, 2025	YAKIRA CAPITAL MANAGEMENT, INC.	0.65%	293.63K	1.59M	293.63K	+100.00%
Jun 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	1.39%	622.87K	3.38M	522.87K	+522.87%
Jun 30, 2025	ALPINE GLOBAL MANAGEMENT, LLC	0.74%	334.48K	1.82M	334.48K	+100.00%
Jun 30, 2025	AFFINITY ASSET ADVISORS, LLC	0.82%	370K	2.01M	0	0
Jun 30, 2025	OMERS ADMINISTRATION CORP	0.95%	426.9K	2.32M	426.9K	+100.00%
Jun 30, 2025	STATE STREET CORP	1.04%	468.99K	2.55M	34.47K	+7.93%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.28%	577.19K	3.13M	62.3K	+12.10%
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	1.72%	770.8K	4.19M	740.69K	+2,460.29%
Jun 30, 2025	VANGUARD GROUP INC	2.89%	1.3M	7.05M	138.49K	+11.94%
Jun 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.16%	73.65K	399.9K	51.68K	+235.33%
Jun 30, 2025	CITADEL ADVISORS LLC	0.27%	120.87K	656.32K	-14.9K	-10.98%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.49%	221.09K	1.2M	63.12K	+39.95%
Jun 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	6.54%	2.94M	15.96M	0	0
Jun 30, 2025	BML CAPITAL MANAGEMENT, LLC	8.51%	3.82M	20.77M	0	0
Jun 30, 2025	ALBERTA INVESTMENT MANAGEMENT CORP	0.53%	239.39K	1.3M	239.39K	+100.00%
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.08%	35.58K	193.22K	7.4K	+26.23%
Jun 30, 2025	RHUMBLINE ADVISERS	0.08%	33.67K	182.83K	5.5K	+19.53%
Jun 30, 2025	MORGAN STANLEY	0.61%	272.47K	1.48M	-46.92K	-14.69%
Jun 30, 2025	D. E. SHAW & CO., INC.	2.78%	1.25M	6.79M	677.35K	+118.14%
Jun 30, 2025	DLD ASSET MANAGEMENT, LP	1.12%	503.84K	2.74M	503.84K	+100.00%
Jun 30, 2025	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.07%	31.79K	172.59K	-1.65K	-4.94%
Jun 30, 2025	MEEDER ASSET MANAGEMENT INC	0%	2.08K	11.31K	0	0
Jun 30, 2025	FMR LLC	0.01%	4.41K	23.92M	3.34K	+313.32%
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	0.08%	34.3K	186.24K	2.63K	+8.31%
Jun 30, 2025	UBS GROUP AG	0.12%	52.26K	283.75K	4.08K	+8.48%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.17%	75.66K	410.82K	75.66K	+100.00%
Jun 30, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0.17%	76.46K	415.19K	5.51K	+7.77%
Jun 30, 2025	PRELUDE CAPITAL MANAGEMENT, LLC	0.17%	76.82K	417.14K	6.92K	+9.90%
Mar 31, 2025	BARCLAYS PLC	0.08%	35.03K	123K	-7.46K	-17.55%
Mar 31, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	6.54%	2.94M	10.2M	2.44M	+486.57%
Mar 31, 2025	BVF INC/IL	5.28%	2.37M	8.23M	0	0
Mar 31, 2025	AFFINITY ASSET ADVISORS, LLC	0.82%	370K	1.28M	370K	+100.00%
Mar 31, 2025	NORTHERN TRUST CORP	0.45%	201.45K	699.04K	9.11K	+4.74%
Mar 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.24%	109.61K	380.33K	80.17K	+272.41%
Mar 31, 2025	IKARIAN CAPITAL, LLC	0.22%	100K	347K	0	0
Mar 31, 2025	FNY INVESTMENT ADVISERS, LLC	0.2%	91.05K	315K	91.05K	+100.00%
Mar 31, 2025	QUADRATURE CAPITAL LTD	0.13%	56.15K	194.82K	56.15K	+100.00%
Mar 31, 2025	O'BRIEN GREENE & CO. INC	0.12%	56K	194.32K	56K	+100.00%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.11%	51.53K	178.8K	-588.56K	-91.95%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.1%	45.92K	159.35K	0	0
Mar 31, 2025	STATE STREET CORP	0.97%	434.53K	1.51M	12.69K	+3.01%
Mar 31, 2025	PRELUDE CAPITAL MANAGEMENT, LLC	0.16%	69.9K	242.55K	69.9K	+100.00%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.15%	514.89K	1.79M	33.03K	+6.85%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.74%	331.8K	1.15M	204.09K	+159.82%
Mar 31, 2025	JPMORGAN CHASE & CO	0.59%	264.42K	917.52K	228.27K	+631.50%
Mar 31, 2025	STONEPINE CAPITAL MANAGEMENT, LLC	0.47%	212.78K	738.36K	212.78K	+100.00%
Mar 31, 2025	WALLEYE CAPITAL LLC	0.23%	102.26K	354.83K	53.87K	+111.34%
Mar 31, 2025		0.08%	37.25K	129.24K	37.25K	+100.00%
Mar 31, 2025	TCG CROSSOVER MANAGEMENT, LLC	5.58%	2.51M	8.69M	0	0
Mar 31, 2025	683 CAPITAL MANAGEMENT, LLC	0.45%	200K	694K	200K	+100.00%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.39%	177.17K	614.76K	3.97K	+2.29%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.35%	157.97K	548.17K	51.31K	+48.10%
Mar 31, 2025	SQUAREPOINT OPS LLC	0.27%	121.93K	423.1K	102.75K	+535.56%
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.22%	100K	347K	100K	+100.00%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.21%	93.94K	326.04K	22.68K	+31.84%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.19%	84.69K	293.86K	43.39K	+105.06%
Mar 31, 2025	CITADEL ADVISORS LLC	0.13%	56.3K	195.36K	56.2K	+56,200.00%
Mar 31, 2025	UBS GROUP AG	0.11%	48.17K	167.16K	34.86K	+261.76%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.11%	48.03K	166.66K	48.03K	+100.00%
Mar 31, 2025	WOODLINE PARTNERS LP	0.09%	40.69K	141.2K	40.69K	+100.00%
Mar 31, 2025	STRS OHIO	0.09%	39.4K	136.72K	0	0
Mar 31, 2025	GSA CAPITAL PARTNERS LLP	0.16%	69.69K	242K	69.69K	+100.00%
Mar 31, 2025	VERITION FUND MANAGEMENT LLC	0.09%	39.39K	136.68K	28.15K	+250.44%
Mar 31, 2025	MORGAN STANLEY	0.71%	319.39K	1.11M	157.34K	+97.10%
Mar 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.35%	159.37K	553.03K	159.37K	+100.00%
Mar 31, 2025	VAZIRANI ASSET MANAGEMENT LLC	0.19%	83.45K	289.57K	83.45K	+100.00%
Mar 31, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0.16%	70.95K	246.19K	70.95K	+100.00%
Mar 31, 2025	KINGSWOOD WEALTH ADVISORS, LLC	0.07%	33.5K	116.25K	2.4K	+7.72%
Mar 31, 2025	ORBIMED ADVISORS LLC	12.87%	5.78M	20.05M	0	0
Mar 31, 2025	BML CAPITAL MANAGEMENT, LLC	8.51%	3.82M	13.27M	3.82M	+100.00%
Mar 31, 2025	BLACKROCK, INC.	3.29%	1.48M	5.13M	1.23K	+0.08%
Mar 31, 2025	VANGUARD GROUP INC	2.58%	1.16M	4.02M	129.61K	+12.58%
Mar 31, 2025	TANG CAPITAL MANAGEMENT LLC	2.07%	929.73K	3.23M	779.73K	+519.82%
Mar 31, 2025	NEWTYN MANAGEMENT, LLC	1.41%	635.15K	2.2M	635.15K	+100.00%
Mar 31, 2025	D. E. SHAW & CO., INC.	1.28%	573.33K	1.99M	562.33K	+5,112.13%
Mar 31, 2024	WELLS FARGO & COMPANY/MN	0.02%	6.86K	64.77K	885	+14.81%
Mar 31, 2024	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	7.78K	73.48K	3.12K	+66.86%
Mar 31, 2024	AMERICAN INTERNATIONAL GROUP, INC.	0.02%	9.6K	90.62K	-83	-0.86%
Mar 31, 2024	CIBC ASSET MANAGEMENT INC	0.03%	10.57K	99.81K	0	0
Mar 31, 2024	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	11.6K	109.54K	0	0
Mar 31, 2024	HSBC HOLDINGS PLC	0.03%	11.98K	113.06K	11.98K	+100.00%
Mar 31, 2024	OCCUDO QUANTITATIVE STRATEGIES LP	0.04%	14.23K	134.28K	14.23K	+100.00%
Mar 31, 2024	BARCLAYS PLC	0.04%	16.03K	152K	-10.7K	-40.04%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.04%	16.78K	158.36K	16.78K	+100.00%
Mar 31, 2024	HRT FINANCIAL LP	0.05%	19.33K	182K	19.33K	+100.00%
Mar 31, 2024	PDT PARTNERS, LLC	0.05%	19.5K	184.11K	9.22K	+89.68%
Mar 31, 2024	UBS GROUP AG	0.05%	19.7K	185.93K	-2.2K	-10.03%
Mar 31, 2024	SG AMERICAS SECURITIES, LLC	0.05%	20.1K	190K	7.76K	+62.90%
Mar 31, 2024	RHUMBLINE ADVISERS	0.05%	20.66K	195.03K	888	+4.49%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.06%	23.85K	225.13K	23.85K	+100.00%
Mar 31, 2024	TREXQUANT INVESTMENT LP	0.07%	26.42K	249.36K	7.56K	+40.07%
Mar 31, 2024	STRS OHIO	0.09%	35.5K	335K	-2.3K	-6.08%
Mar 31, 2024	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.11%	45K	424.8K	0	0
Mar 31, 2024	UBS OCONNOR LLC	0.12%	48.4K	456.92K	-16.3K	-25.19%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.14%	54.23K	511.89K	-3.14K	-5.48%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.17%	67.88K	640.82K	51.66K	+318.46%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.17%	68.3K	645K	55.3K	+425.38%
Mar 31, 2024	SCHONFELD STRATEGIC ADVISORS LLC	0.53%	209.5K	1.98M	209.5K	+100.00%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	0.64%	255.29K	2.41M	255.29K	+100.00%
Mar 31, 2024	STATE STREET CORP	0.96%	380.39K	3.59M	50.29K	+15.23%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	1.01%	400.07K	3.78M	-625	-0.16%
Mar 31, 2024	RA CAPITAL MANAGEMENT, L.P.	5.13%	2.03M	19.19M	0	0
Mar 31, 2024	GENERAL ATLANTIC, L.P.	7.46%	2.96M	27.93M	0	0
Mar 31, 2024	AJOVISTA, LLC	0%	0	-	-1.75K	-100.00%
Mar 31, 2024	ANNAPOLIS FINANCIAL SERVICES, LLC	0%	0	-	-5K	-100.00%
Mar 31, 2024	GLASSMAN WEALTH SERVICES	0%	0	-	-100	-100.00%
Mar 31, 2024	INVESCO LTD.	0%	0	-	-265.07K	-100.00%
Mar 31, 2024	GAMMA INVESTING LLC	0%	97	916	20	+25.97%
Mar 31, 2024	DAIWA SECURITIES GROUP INC.	0%	149	1K	149	+100.00%
Mar 31, 2024	NELSON, VAN DENBURG & CAMPBELL WEALTH MANAGEMENT GROUP, LLC	0%	168	1.59K	168	+100.00%
Mar 31, 2024	COVESTOR LTD	0%	251	2K	0	0
Mar 31, 2024	RUSSELL INVESTMENTS GROUP, LTD.	0%	343	3.24K	-56	-14.04%
Mar 31, 2024	PNC FINANCIAL SERVICES GROUP, INC.	0%	558	5.27K	10	+1.82%
Mar 31, 2024	AMALGAMATED BANK	0%	665	6K	-1.74K	-72.31%
Mar 31, 2024	FEDERATED HERMES, INC.	0%	839	7.92K	0	0
Mar 31, 2024	METROPOLITAN LIFE INSURANCE CO/NY	0%	1.26K	11.85K	0	0
Mar 31, 2024	ZURCHER KANTONALBANK (ZURICH CANTONALBANK)	0%	1.6K	15.13K	1.6K	+100.00%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0%	1.61K	15.17M	0	0
Mar 31, 2024	AMERITAS INVESTMENT PARTNERS, INC.	0.01%	2.02K	19.04M	0	0
Mar 31, 2024	FMR LLC	0.01%	3.77K	35.55K	46	+1.24%
Mar 31, 2024	CITIGROUP INC	0.01%	3.94K	37.23K	367	+10.26%
Mar 31, 2024	NEW YORK STATE COMMON RETIREMENT FUND	0.01%	4.98K	47K	-25	-0.50%
Mar 31, 2024	NISA INVESTMENT ADVISORS, LLC	0.01%	5.54K	52.27K	0	0
Mar 31, 2024	WELLINGTON MANAGEMENT GROUP LLP	0.21%	84.21K	794.94K	84.21K	+100.00%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.33%	130.61K	1.23M	2.35K	+1.83%
Mar 31, 2024	NORTHERN TRUST CORP	0.39%	155.58K	1.47M	-4.03K	-2.52%
Mar 31, 2024	SIO CAPITAL MANAGEMENT, LLC	0.41%	163.36K	1.54M	0	0
Mar 31, 2024	JPMORGAN CHASE & CO	1.12%	442.14K	4.17M	-572.13K	-56.41%
Mar 31, 2024	VANGUARD GROUP INC	2.15%	851.39K	8.04M	11.51K	+1.37%
Mar 31, 2024	COMMODORE CAPITAL LP	3.15%	1.25M	11.8M	543.29K	+76.88%
Mar 31, 2024	BLACKROCK INC.	3.44%	1.36M	12.86M	-26.89K	-1.94%
Mar 31, 2024	BOXER CAPITAL, LLC	5.04%	2M	18.88M	1.25M	+166.67%
Mar 31, 2024	ECOR1 CAPITAL, LLC	8.03%	3.18M	30.04M	0	0
Mar 31, 2024	BVF INC/IL	11.01%	4.37M	41.21M	0	0
Mar 31, 2024	ORBIMED ADVISORS LLC	14.58%	5.78M	54.55M	0	0
Mar 31, 2024	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	27.51%	10.91M	102.97M	0	0
Mar 31, 2024	PARKMAN HEALTHCARE PARTNERS LLC	0.1%	40K	377.6K	40K	+100.00%
Mar 31, 2024	MORGAN STANLEY	0.33%	130.14K	1.23M	-62.31K	-32.38%
Mar 31, 2024	WALLEYE CAPITAL LLC	0.05%	21.33K	201.32K	21.33K	+100.00%
Mar 31, 2024	JANE STREET GROUP, LLC	0.06%	22.02K	207.84K	9.88K	+81.40%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.06%	22.31K	210.59K	-1.41K	-5.93%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.07%	27.96K	263.97K	0	0
Mar 31, 2024	D. E. SHAW & CO., INC.	0.07%	28.97K	273.52K	2.21K	+8.27%
Mar 31, 2024	SQUAREPOINT OPS LLC	0.08%	30.41K	287.08K	30.41K	+100.00%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.08%	30.65K	289.3K	30.65K	+100.00%
Dec 31, 2023	MORGAN STANLEY	0.48%	192.45K	2.11M	85.93K	+80.66%
Dec 31, 2023	INVESCO LTD.	0.67%	265.07K	2.91M	265.07K	+100.00%
Dec 31, 2023	STATE STREET CORP	0.83%	330.1K	3.62M	51.97K	+18.68%
Dec 31, 2023	CITADEL ADVISORS LLC	0.91%	363.03K	3.98M	363.03K	+100.00%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.01%	400.69K	4.4M	39.54K	+10.95%
Dec 31, 2023	COMMODORE CAPITAL LP	1.78%	706.71K	7.75M	-993.29K	-58.43%
Dec 31, 2023	BOXER CAPITAL, LLC	1.89%	750K	8.23M	229.58K	+44.12%
Dec 31, 2023	VANGUARD GROUP INC	2.12%	839.88K	9.21M	66.42K	+8.59%
Dec 31, 2023	JPMORGAN CHASE & CO	2.56%	1.01M	11.13M	1M	+7,726.20%
Dec 31, 2023	BRAIDWELL LP	3.32%	1.32M	14.44M	-337.97K	-20.43%
Dec 31, 2023	BLACKROCK INC.	3.5%	1.39M	15.24M	232.06K	+20.05%
Dec 31, 2023	RA CAPITAL MANAGEMENT, L.P.	5.12%	2.03M	22.3M	1.07M	+111.37%
Dec 31, 2023	GENERAL ATLANTIC, L.P.	7.45%	2.96M	32.46M	0	0
Dec 31, 2023	ECOR1 CAPITAL, LLC	8.02%	3.18M	34.91M	200K	+6.71%
Dec 31, 2023	BVF INC/IL	11%	4.37M	47.89M	0	0
Dec 31, 2023	ORBIMED ADVISORS LLC	14.56%	5.78M	63.4M	0	0
Dec 31, 2023	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	27.48%	10.91M	119.66M	0	0
Dec 31, 2023	AMALGAMATED BANK	0.01%	2.4K	26K	365	+17.92%
Dec 31, 2023	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0.01%	3.21K	35.17K	-1.09K	-25.41%
Dec 31, 2023	CITIGROUP INC	0.01%	3.58K	39.24K	3.57K	+39,644.44%
Dec 31, 2023	FMR LLC	0.01%	3.72K	40.81K	275	+7.98%
Dec 31, 2023	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.01%	4.67K	51K	4.67K	+100.00%
Dec 31, 2023	ANNAPOLIS FINANCIAL SERVICES, LLC	0.01%	5K	54.85K	0	0
Dec 31, 2023	NEW YORK STATE COMMON RETIREMENT FUND	0.01%	5K	55K	-18	-0.36%
Dec 31, 2023	NISA INVESTMENT ADVISORS, LLC	0.01%	5.54K	60.74K	5.4K	+3,941.61%
Dec 31, 2023	WELLS FARGO & COMPANY/MN	0.02%	5.98K	65.56K	1.18K	+24.68%
Dec 31, 2023	ROYAL BANK OF CANADA	0.02%	6.07K	67K	2.44K	+67.38%
Dec 31, 2023	AMERICAN INTERNATIONAL GROUP, INC.	0.02%	9.68K	106.22K	-39	-0.40%
Dec 31, 2023	PDT PARTNERS, LLC	0.03%	10.28K	112.79K	10.28K	+100.00%
Dec 31, 2023	CIBC ASSET MANAGEMENT INC	0.03%	10.57K	115.99K	0	0
Dec 31, 2023	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	11.6K	127.3K	0	0
Dec 31, 2023	JANE STREET GROUP, LLC	0.03%	12.14K	133.14K	12.14K	+100.00%
Dec 31, 2023	SG AMERICAS SECURITIES, LLC	0.03%	12.34K	135K	12.34K	+100.00%
Dec 31, 2023	RENAISSANCE TECHNOLOGIES LLC	0.03%	13K	143K	13K	+100.00%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.04%	16.22K	177.96K	16.22K	+100.00%
Dec 31, 2023	TREXQUANT INVESTMENT LP	0.05%	18.86K	206.87K	18.86K	+100.00%
Dec 31, 2023	RHUMBLINE ADVISERS	0.05%	19.77K	216.9K	1.15K	+6.15%
Dec 31, 2023	UBS GROUP AG	0.06%	21.89K	240.16K	11.25K	+105.64%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.06%	23.71K	260.14K	4.16K	+21.28%
Dec 31, 2023	BARCLAYS PLC	0.07%	26.74K	294K	23.23K	+661.71%
Dec 31, 2023	D. E. SHAW & CO., INC.	0.07%	26.76K	293.57K	26.76K	+100.00%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.07%	27.96K	306.75K	1.14K	+4.25%
Dec 31, 2023	STRS OHIO	0.1%	37.8K	414K	34.9K	+1,203.45%
Dec 31, 2023	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.11%	45K	493.65K	-44.1K	-49.49%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.14%	57.37K	629.35K	-180	-0.31%
Dec 31, 2023	UBS OCONNOR LLC	0.16%	64.7K	709.8K	-60.3K	-48.24%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.32%	128.26K	1.41M	1.4K	+1.10%
Dec 31, 2023	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.38%	152.03K	1.67M	-40K	-20.83%
Dec 31, 2023	NORTHERN TRUST CORP	0.4%	159.6K	1.75M	5.49K	+3.57%
Dec 31, 2023	SIO CAPITAL MANAGEMENT, LLC	0.41%	163.36K	1.79M	163.36K	+100.00%

Insiders

Among the THRD insiders holding of 9.11% of the stake in company, ATLAS VENTURE FUND XI, L.P., 10 percent owner, holds the largest shares of 10.31M. ORBIMED ADVISORS LLC, , is the second largest THRD insider with ownership of 5.78M shares. BONITA DAVID P, , stands third with possession of 5.78M shares of that stake.

Insiders	Designation	Shares Held
ATLAS VENTURE FUND XI, L.P.	10 percent owner	10.31M
ORBIMED ADVISORS LLC		5.78M
BONITA DAVID P		5.78M
HOLLES NATALIE C.	CEO	1.22M
BVF PARTNERS L P/IL	See Explanation of Responses	176.69K
DITTMAN JENNIFER	Chief Development Oper Officer	0
PERSON JULIE	CHIEF ADMINISTRATIVE OFFICER	0
CONNER EDWARD R.	Chief Medical Officer	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Nov 08, 2024	CONNER EDWARD R.	SALE	15.00	2.12K	31.76K	0
Oct 29, 2024	BVF PARTNERS L P/IL	SALE	14.30	64.62K	924.02K	176.69K
Oct 28, 2024	CONNER EDWARD R.	SALE	15.00	2.67K	40.1K	0
Sep 19, 2024	PERSON JULIE	SALE	14.29	9.5K	135.68K	0
Sep 19, 2024	CONNER EDWARD R.	SALE	15.00	4.79K	71.85K	0
Sep 18, 2024	PERSON JULIE	SALE	14.00	503	7.04K	0
Jun 26, 2024	PERSON JULIE	SALE	12.46	10K	124.57K	0
Jun 07, 2024	DITTMAN JENNIFER	SALE	14.17	494	7K	0
May 20, 2024	DITTMAN JENNIFER	SALE	14.00	1.04K	14.59K	0
May 16, 2024	DITTMAN JENNIFER	SALE	14.04	23.58K	331.07K	0
May 09, 2024	HOLLES NATALIE C.	SALE	12.18	20.22K	246.3K	1.22M
Apr 11, 2024	HOLLES NATALIE C.	SALE	12.19	13.56K	165.21K	1.22M
Apr 04, 2024	PERSON JULIE	SALE	10.00	1.11K	11.07K	0
Dec 05, 2023	PERSON JULIE	SALE	10.30	12.86K	132.48K	0
Dec 05, 2023	CONNER EDWARD R.	SALE	10.03	4.79K	48.06K	0
Dec 20, 2022	BVF PARTNERS L P/IL	PURCHASE	4.11	9.6K	39.43K	241.31K
Sep 19, 2022	ORBIMED ADVISORS LLC	PURCHASE	17.00	300K	5.1M	5.78M
Sep 19, 2022	BONITA DAVID P	PURCHASE	17.00	300K	5.1M	5.78M
Sep 19, 2022	ATLAS VENTURE FUND XI, L.P.	PURCHASE	17.00	300K	5.1M	10.31M

Frequently Asked Questions