How many institutions own SPRY stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own SPRY shares is 275, representing 95.47% of the company's common stock.

Who are the major shareholders selling ARS Pharmaceuticals, Inc. stock?

LEGAL & GENERAL GROUP PLC, in the last quarter, reduced its stake in SPRY by -17.96% restricting it's holding to 47.89 thousand shares of worth nearly $384.52K. ROYCE & ASSOCIATES LP also lessened -73.91% of the SPRY shares from its portfolio, reducing its holding to 54.02 thousand shares of worth $433.81K. CITADEL ADVISORS LLC also shunned SPRY shares holding by -9.28% last quarter which brought its holding to 1.77 million shares worth $14.24M.

Investors who are buying SPRY stock?

As per its latest 13F filing, UBS GROUP AG increased its stake in SPRY by 2.24% in the last quarter. The institutional holder raised its holding to 2.26 million shares having worth more than $18.15M. TYRO CAPITAL MANAGEMENT LLC also added 48.81% more shares of SPRY to its portfolio, raising its holding to 2.97 million shares of worth $23.84M. KESTRA ADVISORY SERVICES, LLC also increased its SPRY shares holding by 1,079.25% which brought its holding to 40.92 thousand shares worth $328.59K.

SPRY's major insiders: who are they?

The insider with the most stakes in SPRY is RA CAPITAL MANAGEMENT, L.P. , at the company. Additionally, SPRY stock is highly held by 10 percent owner Flynn James E and CHIEF MEDICAL OFFICER Tanimoto Sarina among others.

Did an insider recently sell SPRY stock?

Company executives, directors, and other insiders own 16.21% percent of ARS Pharmaceuticals, Inc.'s stock. Within the last six months, there have been 2 transaction(s) in which SPRY insiders have sold stock, totaling 28.36K shares. Insiders that have sold shares include FITZPATRICK ALEXANDER A, KARAS ERIC, and DORSEY BRIAN.

Which insider recently purchased SPRY stock?

There have been 0 transaction(s) during the past 6-months in which ARS Pharmaceuticals, Inc. insiders have bought stock, totalling 0 shares

How much of SPRY does insiders own?

Around 103.09K ARS Pharmaceuticals, Inc. shares are held by insiders, which represents about 16.21% of SPRY stock.

Who is the insider with the largest stake?

SPRY , RA CAPITAL MANAGEMENT, L.P. holds the largest portfolio of the company's shares. SPRY shares owned by RA total nearly 9.96 million.

Which institution holds the most shares in SPRY?

UBS GROUP AG is the largest institutional owner in SPRY which holds 2.26 million shares worth $18.15M or 2.29% of the total SPRY shares outstanding followed by TYRO CAPITAL MANAGEMENT LLC with ownership of 2.97 million shares representing 3.01% of the SPRY ownership. KESTRA ADVISORY SERVICES, LLC is the third largest stakeholder with 40.92 thousand shares or 0.04% of the ownership worth more than $328.59K.

Is ARS Pharmaceuticals, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the SPRY is concerned, it is a stock which is optionable.

Is there a short position on SPRY's shares?

Number of SPRY shares short is 17.77M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding SPRY shares are there?

As of today, 98.83M shares of SPRY are outstanding.

Is there many float in SPRY stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, SPRY has 52.09M shares in float.

SPRY short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for SPRY is 11.39.

ARS Pharmaceuticals (SPRY) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares17.98

Short Percent Of Float29.29

Shares Outstanding98.83M

Shares Float52.09M

Shares Short17.77M

Short Ratio11.39

29.29%

Short % of Float

17.98%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

16.21% Percentage of Shares held by All Insiders

95.47% Percentage of Shares held by All Institutions

113.94% Percentage of Float held by Institutions

275

Number of Institutions Holding Shares

Institutional Ownership

About 95.47% of SPRY shares are held by financial institutions. UBS GROUP AG is the top corporate investor, holding 2.26M shares valued at $18.15M. A 2.29% stake in ARS Pharmaceuticals, Inc. is owned by the company. TYRO CAPITAL MANAGEMENT LLC owns 2.97M shares valued at $23.84M, which translates its holding of 3.01% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Mar 31, 2026	UBS GROUP AG	2.29%	2.26M	18.15M	49.46K	+2.24%
Mar 31, 2026	TYRO CAPITAL MANAGEMENT LLC	3.01%	2.97M	23.84M	973.75K	+48.81%
Mar 31, 2026	KESTRA ADVISORY SERVICES, LLC	0.04%	40.92K	328.59K	37.45K	+1,079.25%
Mar 31, 2026	DRW SECURITIES, LLC	0.04%	43.67K	350.63K	43.67K	+100.00%
Mar 31, 2026	LEGAL & GENERAL GROUP PLC	0.05%	47.89K	384.52K	-10.48K	-17.96%
Mar 31, 2026	HEADLANDS TECHNOLOGIES LLC	0.05%	48.21K	387.09K	48.21K	+100.00%
Mar 31, 2026	SCHULHOFF & CO INC	0.05%	51.15K	410.73K	0	0
Mar 31, 2026	PROFUND ADVISORS LLC	0.05%	52.33K	420.19K	9.52K	+22.24%
Mar 31, 2026	ROYCE & ASSOCIATES LP	0.05%	54.02K	433.81K	-153.03K	-73.91%
Mar 31, 2026	FRANKLIN RESOURCES INC	3.33%	3.28M	26.33M	735.45K	+28.92%
Mar 31, 2026	SR ONE CAPITAL MANAGEMENT, LP	4.07%	4.01M	32.22M	0	0
Mar 31, 2026	MILLENNIUM MANAGEMENT LLC	6.07%	5.98M	48.04M	2.81M	+88.83%
Mar 31, 2026	STATE STREET CORP	3.7%	3.64M	29.27M	421.39K	+13.07%
Mar 31, 2026	CITADEL ADVISORS LLC	1.8%	1.77M	14.24M	-181.28K	-9.28%
Mar 31, 2026	GENERAL AMERICAN INVESTORS CO INC	0.74%	727.15K	5.84M	167.2K	+29.86%
Mar 31, 2026	K2 PRINCIPAL FUND, L.P.	0.57%	559.7K	4.49M	549.5K	+5,387.23%
Mar 31, 2026	RAYMOND JAMES FINANCIAL INC	0.53%	525.22K	4.22M	-40.83K	-7.21%
Mar 31, 2026	VANGUARD FIDUCIARY TRUST CO	0.45%	446.31K	3.58M	446.31K	+100.00%
Mar 31, 2026	MORGAN STANLEY	0.32%	316.67K	2.54M	-235.69K	-42.67%
Mar 31, 2026	STEWARD PARTNERS INVESTMENT ADVISORY, LLC	0.15%	146.45K	1.18M	-69.84K	-32.29%
Mar 31, 2026	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.15%	144.3K	1.16M	32.6K	+29.19%
Mar 31, 2026	XTX TOPCO LTD	0.28%	276.11K	2.22M	238.91K	+642.21%
Mar 31, 2026	JPMORGAN CHASE & CO	0.39%	382.8K	2.99M	-34.29K	-8.22%
Mar 31, 2026	DEUTSCHE BANK AG\	0.06%	54.49K	437.56K	5.76K	+11.83%
Mar 31, 2026	COASTAL BRIDGE ADVISORS, LLC	0.06%	55.73K	447.51K	1.9K	+3.53%
Mar 31, 2026	VOYA INVESTMENT MANAGEMENT LLC	0.06%	58.37K	468.74K	24.25K	+71.04%
Mar 31, 2026	AXQ CAPITAL, LP	0.07%	64.3K	516.36K	64.3K	+100.00%
Mar 31, 2026	QUINN OPPORTUNITY PARTNERS LLC	0.16%	155K	1.24M	0	0
Mar 31, 2026	FMR LLC	0.35%	342.04K	2.75M	-56.92K	-14.27%
Mar 31, 2026	INVESTMENT MANAGEMENT ASSOCIATES INC /ADV	0.36%	359.07K	2.88M	47.57K	+15.27%
Mar 31, 2026	FIRST TRUST ADVISORS LP	0.43%	422.04K	3.39M	422.04K	+100.00%
Mar 31, 2026	AMERICAN CENTURY COMPANIES INC	0.43%	428.6K	3.44M	-27.17K	-5.96%
Mar 31, 2026	EMPIRE LIFE INVESTMENTS INC.	0.51%	499.15K	4.05M	146.55K	+41.56%
Mar 31, 2026	GOLDMAN SACHS GROUP INC	0.73%	724.22K	5.82M	-87.82K	-10.81%
Mar 31, 2026	ADAR1 CAPITAL MANAGEMENT, LLC	1.38%	1.36M	10.93M	991.97K	+268.41%
Mar 31, 2026	BANK OF AMERICA CORP /DE/	0.29%	285.73K	2.29M	-196.36K	-40.73%
Mar 31, 2026	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.54%	533.39K	4.28M	-17.54K	-3.18%
Mar 31, 2026	LEVIN CAPITAL STRATEGIES, L.P.	0.56%	552.56K	4.44M	-194.95K	-26.08%
Mar 31, 2026	NEXTECH INVEST, LTD.	0.62%	610.7K	4.9M	-50K	-7.57%
Mar 31, 2026	THIRD POINT LLC	1.01%	1M	8.03M	443.76K	+79.78%
Mar 31, 2026	BAMCO INC /NY/	1.29%	1.27M	10.22M	4.81K	+0.38%
Mar 31, 2026	GEODE CAPITAL MANAGEMENT, LLC	1.55%	1.53M	12.26M	-26.05K	-1.68%
Mar 31, 2026	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	7.61%	7.5M	60.26M	0	0
Mar 31, 2026	ABRDN PLC	4.17%	4.11M	33.03M	557.57K	+15.68%
Mar 31, 2026	BLACKROCK, INC.	5.09%	5.01M	40.25M	-73.06K	-1.44%
Mar 31, 2026	FAS WEALTH PARTNERS, INC.	0.21%	205.41K	1.65M	3K	+1.48%
Mar 31, 2026		0.52%	510.55K	4.1M	510.55K	+100.00%
Mar 31, 2026	NORTHERN TRUST CORP	0.54%	529.28K	4.25M	8.28K	+1.59%
Mar 31, 2026	NUVEEN, LLC	0.15%	150.7K	1.21M	1.1K	+0.73%
Mar 31, 2026	BANK OF NEW YORK MELLON CORP	0.17%	164.06K	1.32M	1.06K	+0.65%
Mar 31, 2026	LANDSCAPE CAPITAL MANAGEMENT, L.L.C.	0.17%	168.79K	1.36M	168.79K	+100.00%
Mar 31, 2026	EVERSEPT PARTNERS, LP	0.14%	136.24K	1.09M	-115.36K	-45.85%
Mar 31, 2026	DAFNA CAPITAL MANAGEMENT LLC	0.14%	139.29K	1.12M	-50.78K	-26.72%
Mar 31, 2026	BOOTHBAY FUND MANAGEMENT, LLC	0.25%	250.6K	2.01M	49.12K	+24.38%
Mar 31, 2026	RUBRIC CAPITAL MANAGEMENT LP	8.12%	8M	64.24M	1.8M	+29.03%
Mar 31, 2026	MATISSE CAPITAL	0.07%	67.23K	539.85K	11.67K	+21.00%
Mar 31, 2026	RHUMBLINE ADVISERS	0.07%	72.26K	580.22K	-1.04K	-1.41%
Mar 31, 2026	ASSUREDPARTNERS INVESTMENT ADVISORS, LLC	0.08%	76.21K	639.41K	431	+0.57%
Mar 31, 2026	ALPS ADVISORS INC	0.08%	80.83K	649.07K	-338	-0.42%
Mar 31, 2026	VALLEY FORGE INVESTMENT CONSULTANTS INC ADV	0.08%	83.23K	668.3K	0	0
Mar 31, 2026	CAMBRIDGE INVESTMENT RESEARCH ADVISORS, INC.	0.09%	87.16K	700K	0	0
Mar 31, 2026	SIT INVESTMENT ASSOCIATES INC	0.09%	92.88K	746K	0	0
Mar 31, 2026	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.1%	96.09K	771.63K	96.09K	+100.00%
Mar 31, 2026	SWISS NATIONAL BANK	0.11%	107.2K	860.82K	0	0
Mar 31, 2026	KNIGHTS OF COLUMBUS ASSET ADVISORS LLC	0.13%	130.03K	1.04M	-697	-0.53%
Mar 31, 2026	JANNEY MONTGOMERY SCOTT LLC	2.05%	2.02M	16.19M	728.63K	+56.58%
Mar 31, 2026	ORBIMED ADVISORS LLC	8.41%	8.29M	66.56M	0	0
Mar 31, 2026	RA CAPITAL MANAGEMENT, L.P.	11.02%	10.86M	87.21M	0	0
Mar 31, 2026	CENTERBOOK PARTNERS LP	0.3%	291.18K	2.34M	-277.18K	-48.77%
Mar 31, 2026	DIMENSIONAL FUND ADVISORS LP	0.17%	172.34K	1.38M	-3.78K	-2.15%
Mar 31, 2026	NORMAN FIELDS, GOTTSCHO CAPITAL MANAGEMENT, LLC	0.04%	39.85K	320K	39.85K	+100.00%
Mar 31, 2026	VANGUARD ASSET MANAGEMENT, LTD	0.04%	40.39K	324.32K	40.39K	+100.00%
Mar 31, 2026	TEJARA CAPITAL LTD	0.21%	210.4K	1.69M	210.4K	+100.00%
Mar 31, 2026	FIL LTD	0.46%	455.58K	3.66M	-354.5K	-43.76%
Mar 31, 2026	UBS ASSET MANAGEMENT AMERICAS INC	0.47%	464.68K	3.73M	160.24K	+52.63%
Dec 31, 2025	EVERSEPT PARTNERS, LP	0.25%	251.59K	2.93M	-724.92K	-74.24%
Dec 31, 2025		0.3%	295.86K	3.45M	295.86K	+100.00%
Dec 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.31%	304.45K	3.55M	-30.7K	-9.16%
Dec 31, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.2%	201.47K	2.35M	201.47K	+100.00%
Dec 31, 2025	BARCLAYS PLC	0.2%	196.39K	2.29M	-32.18K	-14.08%
Dec 31, 2025	INVESTMENT MANAGEMENT ASSOCIATES INC /ADV	0.32%	311.5K	3.63M	311.5K	+100.00%
Dec 31, 2025	EMPIRE LIFE INVESTMENTS INC.	0.36%	352.6K	4.11M	-3.08K	-0.87%
Dec 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.37%	369.57K	4.31M	310.34K	+523.96%
Dec 31, 2025	LISANTI CAPITAL GROWTH, LLC	0.4%	396.51K	4.62M	185.32K	+87.75%
Dec 31, 2025	FMR LLC	0.4%	398.96K	4.65M	-343.55K	-46.27%
Dec 31, 2025	JPMORGAN CHASE & CO	0.42%	417.09K	4.86M	382.03K	+1,089.68%
Dec 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.42%	418.88K	4.88M	28.79K	+7.38%
Dec 31, 2025	AMERICAN CENTURY COMPANIES INC	0.46%	455.77K	5.31M	455.77K	+100.00%
Dec 31, 2025	NORTHERN TRUST CORP	0.53%	521.01K	6.07M	-10.49K	-1.97%
Dec 31, 2025	TYRO CAPITAL MANAGEMENT LLC	2.02%	1.99M	23.24M	1.99M	+100.00%
Dec 31, 2025	WEXFORD CAPITAL LP	0.17%	165.31K	1.93M	-2.93K	-1.74%
Dec 31, 2025	QUINN OPPORTUNITY PARTNERS LLC	0.16%	155K	1.81M	30K	+24.00%
Dec 31, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.12%	115.56K	1.35M	-6.85K	-5.59%
Dec 31, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.19%	190.07K	2.21M	49.57K	+35.28%
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.23%	226.8K	2.64M	-33.5K	-12.87%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	0.49%	482.08K	5.62M	210.06K	+77.22%
Dec 31, 2025	RAYMOND JAMES FINANCIAL INC	0.57%	566.06K	6.59M	-190.29K	-25.16%
Dec 31, 2025	CENTERBOOK PARTNERS LP	0.58%	568.36K	6.62M	55.99K	+10.93%
Dec 31, 2025	BANK OF MONTREAL /CAN/	0.65%	643.41K	7.5M	643.41K	+100.00%
Dec 31, 2025	LEVIN CAPITAL STRATEGIES, L.P.	0.76%	747.51K	8.71M	-16.79K	-2.20%
Dec 31, 2025	FIL LTD	0.82%	810.07K	9.44M	810.07K	+100.00%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	0.82%	812.04K	9.46M	-513.7K	-38.75%
Dec 31, 2025	JANNEY MONTGOMERY SCOTT LLC	1.3%	1.29M	15M	74.81K	+6.17%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.57%	1.55M	18.09M	47.25K	+3.14%
Dec 31, 2025	CITADEL ADVISORS LLC	1.98%	1.95M	22.77M	368.44K	+23.23%
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	3.21%	3.17M	36.91M	3.17M	+100.00%
Dec 31, 2025	UBS GROUP AG	2.24%	2.21M	25.76M	1.55M	+235.04%
Dec 31, 2025	FRANKLIN RESOURCES INC	2.57%	2.54M	29.63M	145.09K	+6.05%
Dec 31, 2025	STATE STREET CORP	3.26%	3.22M	37.55M	328.33K	+11.34%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.56%	550.93K	6.42M	30.17K	+5.79%
Dec 31, 2025	CASDIN CAPITAL, LLC	1.62%	1.6M	18.64M	0	0
Dec 31, 2025	NEXTECH INVEST, LTD.	0.67%	660.7K	7.7M	0	0
Dec 31, 2025	GENERAL AMERICAN INVESTORS CO INC	0.57%	559.96K	6.52M	559.96K	+100.00%
Dec 31, 2025	THIRD POINT LLC	0.56%	556.24K	6.48M	556.24K	+100.00%
Dec 31, 2025	MORGAN STANLEY	0.56%	552.36K	6.44M	-148.05K	-21.14%
Dec 31, 2025	DEUTSCHE BANK AG\	0.05%	48.73K	567.67K	6.78K	+16.15%
Dec 31, 2025	SCHULHOFF & CO INC	0.05%	51.15K	595.9K	7.65K	+17.59%
Dec 31, 2025	PERMANENT CAPITAL MANAGEMENT, LP	0.05%	52.31K	609.37K	-1.04K	-1.94%
Dec 31, 2025	AMERICAN ASSETS INC	0.06%	55K	640.75K	0	0
Dec 31, 2025	K2 PRINCIPAL FUND, L.P.	0.18%	181.1K	2.11M	117.9K	+186.55%
Dec 31, 2025	VANGUARD GROUP INC	3.55%	3.51M	40.88M	8.87K	+0.25%
Dec 31, 2025	ABRDN PLC	3.6%	3.56M	41.43M	459.03K	+14.82%
Dec 31, 2025	SR ONE CAPITAL MANAGEMENT, LP	4.06%	4.01M	46.75M	0	0
Dec 31, 2025	BLACKROCK, INC.	5.15%	5.09M	59.24M	253.99K	+5.26%
Dec 31, 2025	RUBRIC CAPITAL MANAGEMENT LP	6.27%	6.2M	72.23M	1.7M	+37.78%
Dec 31, 2025	SOUTHPOINT CAPITAL ADVISORS LP	1.52%	1.5M	17.48M	0	0
Dec 31, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	7.59%	7.5M	87.42M	0	0
Dec 31, 2025	ORBIMED ADVISORS LLC	8.39%	8.29M	96.56M	0	0
Dec 31, 2025	RA CAPITAL MANAGEMENT, L.P.	10.99%	10.86M	126.53M	0	0
Dec 31, 2025	RHUMBLINE ADVISERS	0.07%	73.29K	853.85M	-7.91K	-9.74%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.08%	74.26K	865.08K	414	+0.56%
Dec 31, 2025	SEI INVESTMENTS CO	0.08%	74.81K	871.5K	26.7K	+55.49%
Dec 31, 2025	ASSUREDPARTNERS INVESTMENT ADVISORS, LLC	0.08%	75.78K	882.83K	17.99K	+31.14%
Dec 31, 2025	SG AMERICAS SECURITIES, LLC	0.08%	76.2K	888K	66.1K	+654.11%
Dec 31, 2025	ALPS ADVISORS INC	0.08%	81.17K	945.61K	31.57K	+63.65%
Dec 31, 2025	VALLEY FORGE INVESTMENT CONSULTANTS INC ADV	0.08%	83.23K	969.57K	0	0
Dec 31, 2025	BAMCO INC /NY/	1.28%	1.27M	14.78M	0	0
Dec 31, 2025	MARSHALL WACE, LLP	0.08%	79.21K	922.84K	-118.11K	-59.86%
Dec 31, 2025	HRT FINANCIAL LP	0.07%	68.65K	799K	68.65K	+100.00%
Dec 31, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.07%	65.75K	566.73K	65.75K	+100.00%
Dec 31, 2025	LEGAL & GENERAL GROUP PLC	0.06%	58.37K	679.99K	3.13K	+5.66%
Dec 31, 2025	MATISSE CAPITAL	0.06%	55.56K	647.29K	-2.23K	-3.86%
Dec 31, 2025	CAMBRIDGE INVESTMENT RESEARCH ADVISORS, INC.	0.09%	87.16K	1.02M	0	0
Dec 31, 2025	SIT INVESTMENT ASSOCIATES INC	0.09%	92.88K	1.08M	18.35K	+24.62%
Dec 31, 2025	SWISS NATIONAL BANK	0.11%	107.2K	1.25M	22.9K	+27.16%
Dec 31, 2025	LEGATO CAPITAL MANAGEMENT LLC	0.11%	109.1K	1.27M	69.69K	+176.82%
Dec 31, 2025	PRINCIPAL FINANCIAL GROUP INC	0.11%	112.77K	1.31M	35.88K	+46.67%
Dec 31, 2025	KNIGHTS OF COLUMBUS ASSET ADVISORS LLC	0.13%	130.73K	1.52M	-3.75K	-2.79%
Dec 31, 2025	NUVEEN, LLC	0.15%	149.6K	1.74M	0	0
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.17%	163.01K	1.9M	8.4K	+5.43%
Dec 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.18%	176.12K	2.05M	-2.03K	-1.14%
Dec 31, 2025	FAS WEALTH PARTNERS, INC.	0.2%	202.41K	2.36M	1.79K	+0.89%
Dec 31, 2025	ROYCE & ASSOCIATES LP	0.21%	207.05K	2.41M	207.05K	+100.00%
Dec 31, 2025	STEWARD PARTNERS INVESTMENT ADVISORY, LLC	0.22%	216.3K	2.52M	69.6K	+47.45%
Sep 30, 2025	BARCLAYS PLC	0.23%	228.57K	2.3M	-393.67K	-63.27%
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	11.04%	10.86M	109.15M	0	0
Sep 30, 2025	ORBIMED ADVISORS LLC	8.43%	8.29M	83.3M	0	0
Sep 30, 2025	VANGUARD GROUP INC	3.56%	3.5M	35.18M	237.63K	+7.28%
Sep 30, 2025	ABRDN PLC	3.15%	3.1M	31.13M	1.59M	+106.11%
Sep 30, 2025	CASDIN CAPITAL, LLC	1.63%	1.6M	16.08M	1.6M	+100.00%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.53%	1.51M	15.13M	163.23K	+12.16%
Sep 30, 2025	SOUTHPOINT CAPITAL ADVISORS LP	1.53%	1.5M	15.08M	-209.07K	-12.23%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.35%	1.33M	13.32M	-138.57K	-9.46%
Sep 30, 2025	NEXTECH INVEST, LTD.	0.67%	660.7K	6.64M	-81.03K	-10.92%
Sep 30, 2025	UBS GROUP AG	0.67%	659.89K	6.63M	-207.05K	-23.88%
Sep 30, 2025	TREXQUANT INVESTMENT LP	0.64%	631.72K	6.35M	631.72K	+100.00%
Sep 30, 2025	K2 PRINCIPAL FUND, L.P.	0.63%	621.81K	6.25M	304.68K	+96.08%
Sep 30, 2025	IKARIAN CAPITAL, LLC	0.57%	562.4K	5.65M	562.4K	+100.00%
Sep 30, 2025	NORTHERN TRUST CORP	0.54%	531.5K	5.34M	46.49K	+9.59%
Sep 30, 2025	CENTERBOOK PARTNERS LP	0.52%	512.37K	5.15M	512.37K	+100.00%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.53%	520.76K	5.23M	78.56K	+17.76%
Sep 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.21%	204.6K	2.06M	204.6K	+100.00%
Sep 30, 2025	WEXFORD CAPITAL LP	0.17%	168.24K	1.69M	-214.32K	-56.02%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.16%	154.6K	1.55M	9.49K	+6.54%
Sep 30, 2025	FREESTONE GROVE PARTNERS LP	0.15%	152.2K	1.53M	152.2K	+100.00%
Sep 30, 2025	WOODLINE PARTNERS LP	0.15%	150.94K	1.52M	-149.48K	-49.76%
Sep 30, 2025	NUVEEN, LLC	0.15%	149.6K	1.5M	10.46K	+7.52%
Sep 30, 2025	HUSSMAN STRATEGIC ADVISORS, INC.	0.15%	147K	1.48M	42K	+40.00%
Sep 30, 2025	STATE STREET CORP	2.94%	2.9M	29.1M	700.76K	+31.93%
Sep 30, 2025	ALLIANCEBERNSTEIN L.P.	2.69%	2.64M	26.55M	-1.18M	-30.94%
Sep 30, 2025	FRANKLIN RESOURCES INC	2.44%	2.4M	24.1M	569.26K	+31.13%
Sep 30, 2025	CITADEL ADVISORS LLC	1.61%	1.59M	15.94M	-656.14K	-29.26%
Sep 30, 2025	FAS WEALTH PARTNERS, INC.	0.2%	200.62K	2.02M	51.46K	+34.50%
Sep 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.19%	186.73K	1.82M	-48.12K	-20.49%
Sep 30, 2025	PERCEPTIVE ADVISORS LLC	0.2%	200K	2.01M	200K	+100.00%
Sep 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.2%	199.15K	2M	199.15K	+100.00%
Sep 30, 2025	MARSHALL WACE, LLP	0.2%	197.32K	1.98M	157.41K	+394.36%
Sep 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	7.63%	7.5M	75.41M	-2.22M	-22.84%
Sep 30, 2025	BLACKROCK, INC.	4.91%	4.83M	48.55M	407.86K	+9.22%
Sep 30, 2025	RUBRIC CAPITAL MANAGEMENT LP	4.57%	4.5M	45.23M	3.21M	+247.52%
Sep 30, 2025	SR ONE CAPITAL MANAGEMENT, LP	4.08%	4.01M	40.33M	0	0
Sep 30, 2025	BIOIMPACT CAPITAL LLC	1.33%	1.3M	13.1M	0	0
Sep 30, 2025	BAMCO INC /NY/	1.29%	1.27M	12.75M	1.23M	+3,071.33%
Sep 30, 2025	JANNEY MONTGOMERY SCOTT LLC	1.23%	1.21M	12.19M	621.6K	+105.10%
Sep 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	1.05%	1.03M	10.4M	1.03M	+100.00%
Sep 30, 2025	EVERSEPT PARTNERS, LP	0.99%	976.51K	9.81M	976.51K	+100.00%
Sep 30, 2025	LEVIN CAPITAL STRATEGIES, L.P.	0.78%	764.29K	7.68M	475.15K	+164.33%
Sep 30, 2025	RAYMOND JAMES FINANCIAL INC	0.77%	756.35K	7.6M	82.98K	+12.32%
Sep 30, 2025	FMR LLC	0.75%	742.51K	7.46M	-824.5K	-52.62%
Sep 30, 2025	MORGAN STANLEY	0.71%	700.41K	7.04M	316.8K	+82.58%
Sep 30, 2025	STEWARD PARTNERS INVESTMENT ADVISORY, LLC	0.15%	146.69K	1.47M	18.51K	+14.44%
Sep 30, 2025	KNIGHTS OF COLUMBUS ASSET ADVISORS LLC	0.14%	134.48K	1.35M	66.38K	+97.49%
Sep 30, 2025	QUINN OPPORTUNITY PARTNERS LLC	0.13%	125K	1.26M	80K	+177.78%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.12%	122.41K	1.23M	41.56K	+51.41%
Sep 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.12%	114.85K	1.15M	-51.33K	-30.89%
Sep 30, 2025	COASTAL BRIDGE ADVISORS, LLC	0.09%	91.68K	921.33K	4.65K	+5.34%
Sep 30, 2025	EPOCH INVESTMENT PARTNERS, INC.	0.09%	89.98K	904.3K	17.2K	+23.63%
Sep 30, 2025	CAMBRIDGE INVESTMENT RESEARCH ADVISORS, INC.	0.09%	87.16K	876K	-1	0.00%
Sep 30, 2025	SWISS NATIONAL BANK	0.09%	84.3K	847.22K	0	0
Sep 30, 2025	VALLEY FORGE INVESTMENT CONSULTANTS INC ADV	0.08%	83.23K	836.41K	0	0
Sep 30, 2025	RHUMBLINE ADVISERS	0.08%	81.2K	816.09K	-57	-0.07%
Sep 30, 2025	PRINCIPAL FINANCIAL GROUP INC	0.08%	76.88K	772.68K	21.44K	+38.66%
Sep 30, 2025	SIT INVESTMENT ASSOCIATES INC	0.08%	74.53K	749K	34.18K	+84.70%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.08%	73.84K	742.11K	12.74K	+20.84%
Sep 30, 2025	CAMPBELL & CO INVESTMENT ADVISER LLC	0.06%	60.53K	608.28K	60.53K	+100.00%
Sep 30, 2025	MATISSE CAPITAL	0.06%	57.79K	580.8K	1.08K	+1.90%
Sep 30, 2025	ASSUREDPARTNERS INVESTMENT ADVISORS, LLC	0.06%	57.79K	580.74K	816	+1.43%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.06%	55.24K	555.19K	418	+0.76%
Sep 30, 2025	AMERICAN ASSETS INC	0.06%	55K	552.75K	55K	+100.00%
Sep 30, 2025	PERMANENT CAPITAL MANAGEMENT, LP	0.05%	53.34K	536.08K	53.34K	+100.00%
Sep 30, 2025	ALPS ADVISORS INC	0.05%	49.6K	498.48K	-3.4K	-6.42%
Sep 30, 2025	SEI INVESTMENTS CO	0.05%	48.11K	483.53K	-36.97K	-43.45%
Sep 30, 2025	QUEST PARTNERS LLC	0.05%	45.82K	460.48K	22.28K	+94.68%
Sep 30, 2025	SCHULHOFF & CO INC	0.04%	43.5K	437.18K	0	0
Sep 30, 2025	DEUTSCHE BANK AG\	0.04%	41.95K	421.61K	4.94K	+13.34%
Sep 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.4%	390.09K	3.92M	100K	+34.47%
Sep 30, 2025	EMPIRE LIFE INVESTMENTS INC.	0.36%	355.69K	3.57M	355.69K	+100.00%
Sep 30, 2025	FIRST TRUST ADVISORS LP	0.36%	352.94K	3.55M	12.82K	+3.77%
Sep 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.34%	335.15K	3.37M	9.5K	+2.92%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.26%	260.3K	2.62M	201.2K	+340.44%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.28%	272.03K	2.73M	-53.33K	-16.39%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.25%	246.17K	2.47M	-82.9K	-25.19%
Sep 30, 2025	JANE STREET GROUP, LLC	0.25%	242.04K	2.43M	242.04K	+100.00%
Sep 30, 2025	LISANTI CAPITAL GROWTH, LLC	0.21%	211.19K	2.12M	-208.89K	-49.73%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.18%	178.15K	1.79M	-2.34K	-1.30%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	3.89%	3.83M	66.76M	-97.01K	-2.47%
Jun 30, 2025	JANNEY MONTGOMERY SCOTT LLC	0.6%	591.43K	10.32M	142.76K	+31.82%
Jun 30, 2025	DIADEMA PARTNERS LP	0.29%	280.7K	4.9M	280.7K	+100.00%
Jun 30, 2025	NEXTECH INVEST, LTD.	0.75%	741.73K	12.94B	-195K	-20.82%
Jun 30, 2025	UBS GROUP AG	0.88%	866.94K	15.13M	275.75K	+46.64%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.89%	878.16K	15.32M	71.12K	+8.81%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.36%	1.34M	23.43M	81.91K	+6.50%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	1.46%	1.43M	25.01M	1.3M	+987.59%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	1.49%	1.46M	25.55M	746.36K	+103.96%
Jun 30, 2025	ABRDN PLC	1.53%	1.5M	26.22M	499.92K	+49.86%
Jun 30, 2025	FMR LLC	1.59%	1.57M	27.34M	576.15K	+58.15%
Jun 30, 2025	SOUTHPOINT CAPITAL ADVISORS LP	1.74%	1.71M	29.82M	1.71M	+100.00%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.76%	1.73M	30.15M	1.73M	+100.00%
Jun 30, 2025	FRANKLIN RESOURCES INC	1.86%	1.83M	31.91M	-28.79K	-1.55%
Jun 30, 2025	BLACKROCK, INC.	4.5%	4.42M	77.19M	124.48K	+2.90%
Jun 30, 2025	ORBIMED ADVISORS LLC	8.43%	8.29M	144.63M	0	0
Jun 30, 2025	STATE STREET CORP	2.23%	2.19M	38.29M	163.26K	+8.04%
Jun 30, 2025	CITADEL ADVISORS LLC	2.28%	2.24M	39.13M	1.44M	+179.82%
Jun 30, 2025	VANGUARD GROUP INC	3.32%	3.26M	56.93M	-225.62K	-6.47%
Jun 30, 2025	SR ONE CAPITAL MANAGEMENT, LP	4.08%	4.01M	70.03M	0	0
Jun 30, 2025	LEVIN CAPITAL STRATEGIES, L.P.	0.29%	289.15K	5.05M	-875.45K	-75.17%
Jun 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.29%	290.09K	5.06M	0	0
Jun 30, 2025	SECTORAL ASSET MANAGEMENT INC	0.07%	65.79K	1.15M	-34.42K	-34.35%
Jun 30, 2025	KNIGHTS OF COLUMBUS ASSET ADVISORS LLC	0.07%	68.09K	1.19M	24.95K	+57.83%
Jun 30, 2025	EPOCH INVESTMENT PARTNERS, INC.	0.07%	72.78K	1.27M	-46.2K	-38.83%
Jun 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.08%	75.46K	1.32M	75.46K	+100.00%
Jun 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.08%	80.85K	1.41M	5.52K	+7.33%
Jun 30, 2025	VALLEY FORGE INVESTMENT CONSULTANTS INC ADV	0.08%	83.23K	1.45M	0	0
Jun 30, 2025	COASTAL BRIDGE ADVISORS, LLC	0.09%	87.03K	1.52M	87.03K	+100.00%
Jun 30, 2025	ROYAL BANK OF CANADA	0.1%	102.79K	1.79M	84.24K	+454.22%
Jun 30, 2025	NICHOLAS INVESTMENT PARTNERS, LP	0.26%	255.11K	4.45M	-356.63K	-58.30%
Jun 30, 2025	ROYCE & ASSOCIATES LP	0.26%	256.27K	4.47M	-386.5K	-60.13%
Jun 30, 2025	AMERIPRISE FINANCIAL INC	0.35%	345.06K	6.02M	240.95K	+231.43%
Jun 30, 2025	HARBOUR CAPITAL ADVISORS, LLC	0.06%	57.95K	970.66K	29.3K	+102.27%
Jun 30, 2025	CASTLEKNIGHT MANAGEMENT LP	0.07%	65.3K	1.14M	0	0
Jun 30, 2025	NEXT CENTURY GROWTH INVESTORS LLC	0.63%	622.82K	10.87M	622.82K	+100.00%
Jun 30, 2025		0.29%	280.7K	4.9M	280.7K	+100.00%
Jun 30, 2025	CORMORANT ASSET MANAGEMENT, LP	1.12%	1.1M	19.2M	-500K	-31.25%
Jun 30, 2025	RUBRIC CAPITAL MANAGEMENT LP	1.32%	1.29M	22.6M	265.78K	+25.83%
Jun 30, 2025	CAPTION MANAGEMENT, LLC	0.1%	100.5K	1.75M	100.5K	+100.00%
Jun 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	9.89%	9.72M	169.69M	-790.15K	-7.51%
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	11.04%	10.86M	189.52M	0	0
Jun 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	25.96K	453.05K	3.62K	+16.18%
Jun 30, 2025	GOTHAM ASSET MANAGEMENT, LLC	0.03%	27.26K	475.62K	14.23K	+109.19%
Jun 30, 2025	CRESSET ASSET MANAGEMENT, LLC	0.03%	30.15K	526.15K	1.9K	+6.73%
Jun 30, 2025	MARSHALL WACE, LLP	0.04%	39.91K	696.5K	-116.72K	-74.52%
Jun 30, 2025	BAMCO INC /NY/	0.04%	40K	698K	40K	+100.00%
Jun 30, 2025	SIT INVESTMENT ASSOCIATES INC	0.04%	40.35K	704K	40.35K	+100.00%
Jun 30, 2025	DIKER MANAGEMENT LLC	0.04%	41K	715.45K	20K	+95.24%
Jun 30, 2025	SCHULHOFF & CO INC	0.04%	43.5K	759.08K	3K	+7.41%
Jun 30, 2025	QUINN OPPORTUNITY PARTNERS LLC	0.05%	45K	785.25K	-66.63K	-59.69%
Jun 30, 2025	AQUATIC CAPITAL MANAGEMENT LLC	0.05%	48.69K	849.61K	48.69K	+100.00%
Jun 30, 2025	MIURA GLOBAL MANAGEMENT, LLC	0.05%	50K	872.5K	-25K	-33.33%
Jun 30, 2025	PEREGRINE CAPITAL MANAGEMENT LLC	0.46%	456.98K	7.97M	-44.84K	-8.94%
Jun 30, 2025	WEXFORD CAPITAL LP	0.39%	382.56K	6.68M	-26K	-6.36%
Jun 30, 2025	WOODLINE PARTNERS LP	0.31%	300.42K	5.24M	-299.9K	-49.96%
Jun 30, 2025	K2 PRINCIPAL FUND, L.P.	0.32%	317.13K	5.53M	-168.23K	-34.66%
Jun 30, 2025	NEUBERGER BERMAN GROUP LLC	0.33%	324.88K	5.67M	7.53K	+2.37%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.33%	325.35K	5.68M	-119.35K	-26.84%
Jun 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.33%	325.65K	5.68M	45.81K	+16.37%
Jun 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.33%	329.07K	5.74M	157.95K	+92.30%
Jun 30, 2025	FIRST TRUST ADVISORS LP	0.35%	340.12K	5.94M	340.12K	+100.00%
Jun 30, 2025	MORGAN STANLEY	0.39%	383.62K	6.69M	-58.9K	-13.31%
Jun 30, 2025	LISANTI CAPITAL GROWTH, LLC	0.43%	420.08K	7.33M	226.25K	+116.72%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.45%	442.2K	7.72M	25.55K	+6.13%
Jun 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.47%	464.03K	8.1M	464.03K	+100.00%
Jun 30, 2025	ARDSLEY ADVISORY PARTNERS LP	0.48%	475K	8.29M	150K	+46.15%
Jun 30, 2025	NORTHERN TRUST CORP	0.49%	485.01K	8.46M	-2.03K	-0.42%
Jun 30, 2025	ALPS ADVISORS INC	0.05%	53K	924.85K	53K	+100.00%
Jun 30, 2025	MATISSE CAPITAL	0.06%	56.71K	989.66K	1K	+1.79%
Jun 30, 2025	LEGATO CAPITAL MANAGEMENT LLC	0.11%	104.13K	1.82M	7.54K	+7.81%
Jun 30, 2025	HUSSMAN STRATEGIC ADVISORS, INC.	0.11%	105K	1.83M	105K	+100.00%
Jun 30, 2025	AVIDITY PARTNERS MANAGEMENT LP	0.14%	140K	2.44M	140K	+100.00%
Jun 30, 2025	FAS WEALTH PARTNERS, INC.	0.15%	149.16K	2.6M	9.63K	+6.90%
Jun 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.24%	234.84K	4.27M	234.84K	+100.00%
Jun 30, 2025	ALLSPRING GLOBAL INVESTMENTS HOLDINGS, LLC	0.3%	294.11K	5.13M	-74.45K	-20.20%
Jun 30, 2025	OCTAGON CAPITAL ADVISORS LP	1.37%	1.35M	23.56M	725K	+116.00%
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.26%	256.97K	4.48M	52.77K	+25.84%
Jun 30, 2025	FIRST TURN MANAGEMENT, LLC	0.46%	455.95K	7.96M	-213.06K	-31.85%
Jun 30, 2025	BIOIMPACT CAPITAL LLC	1.33%	1.3M	22.74M	-9.71K	-0.74%
Jun 30, 2025	BARCLAYS PLC	0.63%	622.24K	10.86M	490.2K	+371.27%
Jun 30, 2025	RAYMOND JAMES FINANCIAL INC	0.68%	673.37K	11.75M	-33.42K	-4.73%
Mar 31, 2025	SR ONE CAPITAL MANAGEMENT, LP	4.09%	4.01M	50.48M	0	0
Mar 31, 2025	FIRST TURN MANAGEMENT, LLC	0.68%	669.01K	8.42M	75.72K	+12.76%
Mar 31, 2025	RAYMOND JAMES FINANCIAL INC	0.72%	706.79K	8.89M	83.51K	+13.40%
Mar 31, 2025	LEVIN CAPITAL STRATEGIES, L.P.	1.19%	1.16M	14.65M	696.97K	+149.04%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.29%	1.26M	15.86M	22.32K	+1.80%
Mar 31, 2025	CORMORANT ASSET MANAGEMENT, LP	1.63%	1.6M	20.13M	1.1M	+220.00%
Mar 31, 2025	FRANKLIN RESOURCES INC	1.89%	1.86M	23.37M	-118.87K	-6.01%
Mar 31, 2025	STATE STREET CORP	2.07%	2.03M	25.55M	-718.67K	-26.13%
Mar 31, 2025	VANGUARD GROUP INC	3.56%	3.49M	43.88M	23.34K	+0.67%
Mar 31, 2025	PEREGRINE CAPITAL MANAGEMENT LLC	0.51%	501.82K	6.31M	78.26K	+18.48%
Mar 31, 2025	ALLSPRING GLOBAL INVESTMENTS HOLDINGS, LLC	0.38%	368.56K	4.64M	24.39K	+7.09%
Mar 31, 2025	JANNEY MONTGOMERY SCOTT LLC	0.46%	448.67K	5.64M	421.51K	+1,552.07%
Mar 31, 2025	ALLIANCEBERNSTEIN L.P.	4%	3.92M	49.35M	42.07K	+1.08%
Mar 31, 2025		0.16%	154.46K	1.94M	154.46K	+100.00%
Mar 31, 2025	BLACKROCK, INC.	4.38%	4.3M	54.08M	-275.5K	-6.02%
Mar 31, 2025	ORBIMED ADVISORS LLC	8.45%	8.29M	104.27M	0	0
Mar 31, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	10.72%	10.51M	132.27M	0	0
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.45%	444.7K	5.59M	283.75K	+176.29%
Mar 31, 2025	OCTAGON CAPITAL ADVISORS LP	0.64%	625K	7.86M	625K	+100.00%
Mar 31, 2025	BIOIMPACT CAPITAL LLC	1.34%	1.31M	16.52M	1.31M	+100.00%
Mar 31, 2025	CITADEL ADVISORS LLC	0.15%	142.6K	1.79M	-87.9K	-38.13%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.21%	204.2K	2.57M	32.82K	+19.15%
Mar 31, 2025	ADVISOR RESOURCE COUNCIL	0.25%	249.23K	3.14M	249.23K	+100.00%
Mar 31, 2025	ARDSLEY ADVISORY PARTNERS LP	0.33%	325K	4.09M	325K	+100.00%
Mar 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.29%	279.84K	3.52M	32.53K	+13.15%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.73%	717.95K	9.03M	-168.16K	-18.98%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.82%	807.04K	10.15M	-132.24K	-14.08%
Mar 31, 2025	FMR LLC	1.01%	990.86K	12.47M	-111.37K	-10.10%
Mar 31, 2025	ROYCE & ASSOCIATES LP	0.66%	642.77K	8.09M	-286.85K	-30.86%
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	11.08%	10.86M	136.63M	0	0
Mar 31, 2025	WOODLINE PARTNERS LP	0.61%	600.32K	7.55M	-518.96K	-46.37%
Mar 31, 2025	ABRDN PLC	1.02%	1M	12.61M	1M	+100.00%
Mar 31, 2025	RUBRIC CAPITAL MANAGEMENT LP	1.05%	1.03M	12.95M	1.03M	+100.00%
Mar 31, 2025	FAS WEALTH PARTNERS, INC.	0.14%	139.54K	1.76M	44.83K	+47.34%
Mar 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.3%	290.09K	3.65M	-963.63K	-76.86%
Mar 31, 2025	NEUBERGER BERMAN GROUP LLC	0.32%	317.35K	3.99M	30.5K	+10.63%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.42%	416.66K	5.24M	-10.82K	-2.53%
Mar 31, 2025	MARSHALL WACE, LLP	0.16%	156.64K	1.97M	103.73K	+196.06%
Mar 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.17%	171.12K	2.15M	-173.82K	-50.39%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.19%	187.65K	2.36M	-8.81K	-4.49%
Mar 31, 2025	LISANTI CAPITAL GROWTH, LLC	0.2%	193.83K	2.44M	193.83K	+100.00%
Mar 31, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.2%	197.54K	2.49M	172.91K	+702.07%
Mar 31, 2025	WEXFORD CAPITAL LP	0.42%	408.55K	5.14M	39.05K	+10.57%
Mar 31, 2025	MORGAN STANLEY	0.45%	442.51K	5.57M	9.91K	+2.29%
Mar 31, 2025	K2 PRINCIPAL FUND, L.P.	0.49%	485.36K	6.11M	485.36K	+100.00%
Mar 31, 2025	NORTHERN TRUST CORP	0.5%	487.04K	6.13M	8.89K	+1.86%
Mar 31, 2025	UBS GROUP AG	0.6%	591.18K	7.44M	-421.52K	-41.62%
Mar 31, 2025	NICHOLAS INVESTMENT PARTNERS, LP	0.62%	611.74K	7.7M	439.72K	+255.62%

Insiders

Among the SPRY insiders holding of 16.21% of the stake in company, RA CAPITAL MANAGEMENT, L.P., , holds the largest shares of 9.96M. FLYNN JAMES E, 10 percent owner, is the second largest SPRY insider with ownership of 4.89M shares. TANIMOTO SARINA, CHIEF MEDICAL OFFICER, stands third with possession of 1.25M shares of that stake.

Insiders	Designation	Shares Held
RA CAPITAL MANAGEMENT, L.P.		9.96M
FLYNN JAMES E	10 percent owner	4.89M
TANIMOTO SARINA	CHIEF MEDICAL OFFICER	1.25M
LOWENTHAL RICHARD E	PRESIDENT AND CEO	1.2M
SHAWVER LAURA	director	210.35K
FITZPATRICK ALEXANDER A	Chief Legal Officer	90.91K
KARAS ERIC	Chief Commercial Officer	12.18K
DORSEY BRIAN	Chief Operating Officer	10.79K
SCOTT KATHLEEN D.	Chief Financial Officer	10.04K
CHAKMA JUSTIN	Chief Business Officer	0
SAUNDERS BRENT L	director	0
ORBIMED ADVISORS LLC	director	0
THOMPSON PETER A.	director	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Jun 12, 2026	FITZPATRICK ALEXANDER A	SALE	10.00	3.36K	33.55K	90.91K
Jun 12, 2026	KARAS ERIC	SALE	10.00	25K	250K	12.18K
Nov 13, 2025	DORSEY BRIAN	SALE	8.71	21.83K	190.05K	10.79K
Nov 12, 2025	CHAKMA JUSTIN	SALE	8.86	136.38K	1.21M	0
Aug 21, 2025	LOWENTHAL RICHARD E	SALE	14.49	50K	724.35K	1.2M
Aug 21, 2025	SCOTT KATHLEEN D.	SALE	15.00	12.5K	187.5K	10.04K
Aug 20, 2025	TANIMOTO SARINA	SALE	14.09	37.66K	530.63K	1.25M
Aug 19, 2025	TANIMOTO SARINA	SALE	14.03	12.34K	173.13K	1.29M
Jul 01, 2025	KARAS ERIC	SALE	16.99	15K	254.86K	10.32K
Jun 27, 2025	FLYNN JAMES E	SALE	18.46	370.07K	6.83M	4.89M
Jun 18, 2025	KARAS ERIC	SALE	16.00	15K	240K	7.7K
May 20, 2025	FITZPATRICK ALEXANDER A	SALE	14.10	102.97K	1.45M	89.61K
May 20, 2025	SAUNDERS BRENT L	SALE	14.25	120K	1.71M	0
May 20, 2025	SCOTT KATHLEEN D.	SALE	14.10	50K	705.17K	7.42K
Apr 07, 2025	SHAWVER LAURA	SALE	12.30	50K	615.07K	210.35K
Mar 20, 2025	KARAS ERIC	SALE	14.00	10K	140K	7.7K
Mar 06, 2025	SHAWVER LAURA	SALE	11.21	49.6K	556.05K	210.35K
Mar 05, 2025	SHAWVER LAURA	SALE	11.00	400	4.4K	210.35K
Feb 03, 2025	SHAWVER LAURA	SALE	12.31	50K	615.57K	210.35K
Jan 06, 2025	SHAWVER LAURA	SALE	11.10	50K	555.07K	210.35K
Dec 17, 2024	LOWENTHAL RICHARD E	SALE	11.67	50K	583.53K	1.1M
Dec 17, 2024	TANIMOTO SARINA	SALE	11.67	50K	583.53K	1.1M
Dec 13, 2024	CHAKMA JUSTIN	SALE	12.06	27.27K	328.97K	136.38K
Dec 12, 2024	DORSEY BRIAN	SALE	12.30	25K	307.43K	6.02K
Dec 12, 2024	CHAKMA JUSTIN	SALE	12.27	117.33K	1.44M	136.38K
Dec 11, 2024	DORSEY BRIAN	SALE	12.43	15K	186.43K	6.02K
Dec 10, 2024	LOWENTHAL RICHARD E	SALE	13.16	50K	658.16K	1.15M
Dec 10, 2024	CHAKMA JUSTIN	SALE	13.15	50K	657.63K	136.38K
Dec 10, 2024	TANIMOTO SARINA	SALE	13.16	50K	658.16K	1.15M
Dec 06, 2024	CHAKMA JUSTIN	SALE	14.23	50K	711.62K	136.38K
Dec 05, 2024	CHAKMA JUSTIN	SALE	14.13	49.64K	701.64K	136.38K
Dec 04, 2024	KARAS ERIC	SALE	14.00	6.28K	87.96K	5.69K
Dec 04, 2024	SHAWVER LAURA	SALE	13.75	14.77K	203.11K	210.35K
Dec 04, 2024	CHAKMA JUSTIN	SALE	13.95	45K	627.94K	136.38K
Dec 03, 2024	SHAWVER LAURA	SALE	13.26	87.98K	1.17M	210.35K
Dec 03, 2024	CHAKMA JUSTIN	SALE	13.19	45K	593.4K	136.38K
Dec 02, 2024	CHAKMA JUSTIN	SALE	13.67	45K	615.22K	136.38K
Dec 02, 2024	KARAS ERIC	SALE	14.11	3.72K	52.46K	5.69K
Dec 02, 2024	SHAWVER LAURA	SALE	14.34	901	12.92K	210.35K
Nov 27, 2024	CHAKMA JUSTIN	SALE	14.39	25K	359.75K	136.38K
Nov 26, 2024	CHAKMA JUSTIN	SALE	14.05	42.19K	592.57K	161.38K
Nov 25, 2024	CHAKMA JUSTIN	SALE	14.00	32.81K	459.42K	203.57K
Nov 19, 2024	LOWENTHAL RICHARD E	SALE	13.95	50K	697.45K	1.2M
Nov 19, 2024	TANIMOTO SARINA	SALE	13.95	50K	697.45K	1.2M
Nov 12, 2024	LOWENTHAL RICHARD E	SALE	17.64	4.88K	86.02K	1.25M
Nov 12, 2024	TANIMOTO SARINA	SALE	17.64	4.88K	86.02K	1.25M
Nov 12, 2024	FLYNN JAMES E	SALE	17.77	9.55K	169.76K	5.26M
Nov 11, 2024	FLYNN JAMES E	SALE	18.15	223.63K	4.06M	5.27M
Oct 16, 2024	SCOTT KATHLEEN D.	SALE	16.00	12.5K	200K	4.95K
Oct 15, 2024	LOWENTHAL RICHARD E	SALE	14.88	50K	743.82K	1.3M
Oct 15, 2024	TANIMOTO SARINA	SALE	14.88	50K	743.82K	1.3M
Oct 08, 2024	LOWENTHAL RICHARD E	SALE	13.83	50K	691.39K	1.35M
Oct 08, 2024	TANIMOTO SARINA	SALE	13.83	50K	691.39K	1.35M
Sep 18, 2024	KARAS ERIC	SALE	14.00	10K	140K	5.69K
Sep 17, 2024	LOWENTHAL RICHARD E	SALE	12.93	50K	646.68K	1.4M
Sep 17, 2024	TANIMOTO SARINA	SALE	12.93	50K	646.68K	1.4M
Sep 10, 2024	TANIMOTO SARINA	SALE	11.50	50K	574.87K	1.4M
Sep 10, 2024	LOWENTHAL RICHARD E	SALE	11.50	50K	574.87K	1.4M
Aug 26, 2024	ORBIMED ADVISORS LLC	SALE	13.00	83.7K	1.09M	0
Aug 26, 2024	THOMPSON PETER A.	SALE	13.00	83.7K	1.09M	0
Aug 23, 2024	THOMPSON PETER A.	SALE	13.03	69.5K	905.59K	83.7K
Aug 23, 2024	ORBIMED ADVISORS LLC	SALE	13.03	69.5K	905.59K	83.7K
Aug 22, 2024	THOMPSON PETER A.	SALE	12.94	391.48K	5.07M	153.2K
Aug 22, 2024	ORBIMED ADVISORS LLC	SALE	12.94	391.48K	5.07M	153.2K
Aug 21, 2024	ORBIMED ADVISORS LLC	SALE	14.61	13.3K	194.31K	544.68K
Aug 21, 2024	THOMPSON PETER A.	SALE	14.61	13.3K	194.31K	544.68K
Aug 20, 2024	TANIMOTO SARINA	SALE	16.26	2.3K	37.4K	1.5M
Aug 20, 2024	LOWENTHAL RICHARD E	SALE	16.26	2.3K	37.4K	1.5M
Aug 20, 2024	DORSEY BRIAN	SALE	15.00	50K	750K	6.02K
Aug 20, 2024	SCOTT KATHLEEN D.	SALE	16.00	12.5K	200K	13.2K
Aug 19, 2024	KARAS ERIC	SALE	14.00	10K	140K	5.69K
Aug 13, 2024	LOWENTHAL RICHARD E	SALE	12.76	35.4K	451.88K	1.45M
Aug 13, 2024	DORSEY BRIAN	SALE	13.00	30K	390K	6.02K
Aug 13, 2024	TANIMOTO SARINA	SALE	12.76	35.4K	451.88K	1.45M
Jul 16, 2024	LOWENTHAL RICHARD E	SALE	11.40	50K	570.14K	1.55M
Jul 16, 2024	TANIMOTO SARINA	SALE	11.40	50K	570.14K	1.55M
Jul 09, 2024	LOWENTHAL RICHARD E	SALE	9.62	50K	480.89K	1.5M
Jul 09, 2024	TANIMOTO SARINA	SALE	9.62	50K	480.89K	1.5M
Jun 12, 2024	TANIMOTO SARINA	SALE	9.15	47.83K	437.46K	1.55M
Jun 12, 2024	LOWENTHAL RICHARD E	SALE	9.15	47.83K	437.46K	1.55M
Jun 11, 2024	TANIMOTO SARINA	SALE	9.00	2.17K	19.5K	1.59M
Jun 11, 2024	LOWENTHAL RICHARD E	SALE	9.00	2.17K	19.5K	1.59M
May 16, 2024	TANIMOTO SARINA	SALE	9.06	44.75K	405.31K	1.6M
May 16, 2024	LOWENTHAL RICHARD E	SALE	9.06	44.75K	405.31K	1.6M
May 15, 2024	LOWENTHAL RICHARD E	SALE	9.05	2.38K	21.56K	1.64M
May 15, 2024	TANIMOTO SARINA	SALE	9.05	2.38K	21.56K	1.64M
May 14, 2024	LOWENTHAL RICHARD E	SALE	9.01	2.87K	25.88K	1.64M
May 14, 2024	TANIMOTO SARINA	SALE	9.01	2.87K	25.88K	1.64M
May 07, 2024	LOWENTHAL RICHARD E	SALE	9.34	50K	467.14K	1.6M
May 07, 2024	TANIMOTO SARINA	SALE	9.34	50K	467.14K	1.6M
Apr 16, 2024	LOWENTHAL RICHARD E	SALE	9.28	50K	464.02K	1.65M
Apr 16, 2024	TANIMOTO SARINA	SALE	9.28	50K	464.02K	1.65M
Apr 09, 2024	TANIMOTO SARINA	SALE	9.28	50K	463.89K	1.65M
Apr 09, 2024	LOWENTHAL RICHARD E	SALE	9.28	50K	463.89K	1.65M
Mar 27, 2024	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	9.79	505.95K	4.95M	9.96M
Mar 26, 2024	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	9.55	457.75K	4.37M	9.45M
Mar 25, 2024	TANIMOTO SARINA	SALE	9.12	47.64K	434.61K	1.7M
Mar 25, 2024	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	9.06	437.6K	3.96M	8.99M
Mar 25, 2024	LOWENTHAL RICHARD E	SALE	9.12	47.64K	434.61K	1.7M
Mar 22, 2024	LOWENTHAL RICHARD E	SALE	9.03	1.02K	9.18K	1.75M
Mar 22, 2024	TANIMOTO SARINA	SALE	9.03	1.02K	9.18K	1.75M
Mar 21, 2024	LOWENTHAL RICHARD E	SALE	9.00	372	3.35K	1.75M
Mar 21, 2024	TANIMOTO SARINA	SALE	9.00	372	3.35K	1.75M
Mar 19, 2024	LOWENTHAL RICHARD E	SALE	9.03	976	8.81K	1.75M
Mar 19, 2024	TANIMOTO SARINA	SALE	9.03	976	8.81K	1.75M
Mar 15, 2024	TANIMOTO SARINA	SALE	9.14	48.3K	441.49K	1.7M
Mar 15, 2024	LOWENTHAL RICHARD E	SALE	9.14	48.3K	441.49K	1.7M
Mar 14, 2024	TANIMOTO SARINA	SALE	9.00	205	1.85K	1.74M
Mar 14, 2024	LOWENTHAL RICHARD E	SALE	9.00	205	1.85K	1.74M
Mar 13, 2024	LOWENTHAL RICHARD E	SALE	9.00	1.5K	13.5K	1.74M
Mar 13, 2024	TANIMOTO SARINA	SALE	9.00	1.5K	13.5K	1.74M
Feb 29, 2024	TANIMOTO SARINA	SALE	9.02	800	7.22K	1.75M
Feb 29, 2024	LOWENTHAL RICHARD E	SALE	9.02	800	7.22K	1.75M
Feb 28, 2024	TANIMOTO SARINA	SALE	9.02	25.46K	229.63K	1.75M
Feb 28, 2024	LOWENTHAL RICHARD E	SALE	9.02	25.46K	229.63K	1.75M
Feb 26, 2024	TANIMOTO SARINA	SALE	9.01	100	901	1.77M
Feb 26, 2024	LOWENTHAL RICHARD E	SALE	9.01	100	901	1.77M
Sep 29, 2023	FITZPATRICK ALEXANDER A	PURCHASE	3.78	46.26K	174.99K	89.23K
Sep 28, 2023	FITZPATRICK ALEXANDER A	PURCHASE	3.62	40K	144.96K	42.97K
Sep 21, 2023	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	2.97	2.51M	7.45M	8.37M
Sep 01, 2023	SHAWVER LAURA	SALE	7.71	100K	770.52K	210.35K
Aug 29, 2023	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	6.20	3.75M	23.25M	5.86M
Aug 29, 2023	THOMPSON PETER A.	PURCHASE	6.20	500K	3.1M	8.02M
Aug 29, 2023	ORBIMED ADVISORS LLC	PURCHASE	6.20	500K	3.1M	8.02M
Aug 04, 2023	SHAWVER LAURA	SALE	7.06	18.9K	133.47K	210.35K
Aug 03, 2023	SHAWVER LAURA	SALE	7.01	26.11K	183.02K	210.35K
Aug 02, 2023	SHAWVER LAURA	SALE	7.09	36.28K	257.26K	210.35K
Aug 01, 2023	SHAWVER LAURA	SALE	7.19	18.72K	134.58K	210.35K
Jul 07, 2023	SHAWVER LAURA	SALE	6.36	8.86K	56.37K	210.35K
Jul 06, 2023	SHAWVER LAURA	SALE	6.34	33.51K	212.55K	210.35K
Jul 05, 2023	SHAWVER LAURA	SALE	6.41	31.11K	199.55K	210.35K
Jul 03, 2023	SHAWVER LAURA	SALE	6.72	26.52K	178.35K	210.35K
Jun 02, 2023	SHAWVER LAURA	SALE	6.95	26.94K	187.24K	210.35K
Jun 01, 2023	SHAWVER LAURA	SALE	6.80	73.06K	496.8K	210.35K
May 09, 2023	SHAWVER LAURA	SALE	5.31	42.9K	227.8K	210.35K
May 08, 2023	SHAWVER LAURA	SALE	6.16	57.1K	351.74K	210.35K
Nov 09, 2022	SHAWVER LAURA	SALE	4.58	43.9K	201.04K	210.35K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES28.36K2

NET SHARES-28.36K2

SHARES HELD103.09K2

% NET SHARES-127.51%0%

Frequently Asked Questions