How many institutions own SPRB stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own SPRB shares is 15, representing 41.05% of the company's common stock.

Who are the major shareholders selling Spruce Biosciences, Inc. stock?

ADVISOR GROUP HOLDINGS, INC., in the last quarter, reduced its stake in SPRB by -100% restricting it's holding to 0 shares of worth nearly -. CABLE CAR CAPITAL LLC also lessened -100% of the SPRB shares from its portfolio, reducing its holding to 0 shares of worth -. CARLYLE GROUP INC. also shunned SPRB shares holding by -98.67% last quarter which brought its holding to 38.62 thousand shares worth $3.30M.

Investors who are buying SPRB stock?

As per its latest 13F filing, TOWER RESEARCH CAPITAL LLC (TRC) increased its stake in SPRB by 100% in the last quarter. The institutional holder raised its holding to 1 shares having worth more than $87.00. ROYAL BANK OF CANADA also added 100% more shares of SPRB to its portfolio, raising its holding to 40 shares of worth $3.00K. JONES FINANCIAL COMPANIES LLLP also increased its SPRB shares holding by 100% which brought its holding to 84 shares worth $7.32K.

SPRB's major insiders: who are they?

The insider with the most stakes in SPRB is Novo Holdings A/S , 10 percent owner at the company. Additionally, SPRB stock is highly held by director Chaya Moghrabi Dina and Omega Fund VI, L.P. among others.

Did an insider recently sell SPRB stock?

Company executives, directors, and other insiders own 8.68% percent of Spruce Biosciences, Inc.'s stock. Within the last six months, there have been 1 transaction(s) in which SPRB insiders have sold stock, totaling 25 shares. Insiders that have sold shares include PARKMAN HEALTHCARE PARTNERS LLC, NOVO HOLDINGS A/S, and SIMPSON CAMILLA V.

Which insider recently purchased SPRB stock?

There have been 0 transaction(s) during the past 6-months in which Spruce Biosciences, Inc. insiders have bought stock, totalling 0 shares

How much of SPRB does insiders own?

Around 1.05K Spruce Biosciences, Inc. shares are held by insiders, which represents about 8.68% of SPRB stock.

Who is the insider with the largest stake?

SPRB 10 percent owner, Novo Holdings A/S holds the largest portfolio of the company's shares. SPRB shares owned by Novo total nearly 2.55 million.

Which institution holds the most shares in SPRB?

TOWER RESEARCH CAPITAL LLC (TRC) is the largest institutional owner in SPRB which holds 1 shares worth $87.00 or 0% of the total SPRB shares outstanding followed by CALDWELL SUTTER CAPITAL, INC. with ownership of 13 shares representing 0% of the SPRB ownership. ROYAL BANK OF CANADA is the third largest stakeholder with 40 shares or 0.01% of the ownership worth more than $3.00K.

Is Spruce Biosciences, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the SPRB is concerned, it is a stock which is not optionable.

Is there a short position on SPRB's shares?

Number of SPRB shares short is 6.83K. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding SPRB shares are there?

As of today, 563.08K shares of SPRB are outstanding.

Is there many float in SPRB stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, SPRB has 561.91K shares in float.

SPRB short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for SPRB is 0.31.

Spruce Biosciences (SPRB) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableNo

Short Percent Of Outstanding Shares1.21

Short Percent Of Float1.23

Shares Outstanding563.08K

Shares Float561.91K

Shares Short6.83K

Short Ratio0.31

1.23%

Short % of Float

1.21%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

8.68% Percentage of Shares held by All Insiders

41.05% Percentage of Shares held by All Institutions

44.95% Percentage of Float held by Institutions

Number of Institutions Holding Shares

Institutional Ownership

About 41.05% of SPRB shares are held by financial institutions. TOWER RESEARCH CAPITAL LLC (TRC) is the top corporate investor, holding 1 shares valued at $87.00. A 0% stake in Spruce Biosciences, Inc. is owned by the company. CALDWELL SUTTER CAPITAL, INC. owns 13 shares valued at $1.13K, which translates its holding of 0% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	TOWER RESEARCH CAPITAL LLC (TRC)	0%	1	87	1	+100.00%
Dec 31, 2025	CALDWELL SUTTER CAPITAL, INC.	0%	13	1.13K	0	0
Dec 31, 2025	ROYAL BANK OF CANADA	0.01%	40	3K	40	+100.00%
Dec 31, 2025	JONES FINANCIAL COMPANIES LLLP	0.01%	84	7.32K	84	+100.00%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	0.02%	93	8.1K	90	+3,000.00%
Dec 31, 2025	UBS GROUP AG	0.87%	4.9K	427.01K	4.77K	+3,613.64%
Dec 31, 2025	ADVISOR GROUP HOLDINGS, INC.	0%	0	-	-133	-100.00%
Dec 31, 2025	CABLE CAR CAPITAL LLC	0%	0	-	-26.67K	-100.00%
Dec 31, 2025	NORTHERN TRUST CORP	0.43%	2.42K	210.98K	2.42K	+100.00%
Dec 31, 2025	IKARIAN CAPITAL, LLC	21.55%	121.36K	10.57M	108.02K	+810.26%
Dec 31, 2025		12.43%	70K	6.1M	70K	+100.00%
Dec 31, 2025	CITADEL ADVISORS LLC	12.43%	70K	6.1M	70K	+100.00%
Dec 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	10.47%	58.95K	5.14M	58.95K	+100.00%
Dec 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	10.3%	58K	5.05M	58K	+100.00%
Dec 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	9.18%	51.67K	4.5M	51.67K	+100.00%
Dec 31, 2025	BOOTHBAY FUND MANAGEMENT, LLC	8.51%	47.93K	4.18M	47.93K	+100.00%
Dec 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	7.1%	40K	3.48M	40K	+100.00%
Dec 31, 2025	CARLYLE GROUP INC.	6.86%	38.62K	3.3M	-2.86M	-98.67%
Dec 31, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	4.49%	25.27K	2.2M	25.27K	+100.00%
Dec 31, 2025	SCHONFELD STRATEGIC ADVISORS LLC	4.4%	24.77K	2.16M	24.77K	+100.00%
Dec 31, 2025	QUINN OPPORTUNITY PARTNERS LLC	4.05%	22.81K	1.99M	22.81K	+100.00%
Dec 31, 2025	CALIGAN PARTNERS LP	3.64%	20.51K	1.79M	20.51K	+100.00%
Dec 31, 2025	STONEPINE CAPITAL MANAGEMENT, LLC	3.51%	19.74K	1.72M	19.74K	+100.00%
Dec 31, 2025	VANGUARD GROUP INC	3.17%	17.87K	1.56M	17.87K	+100.00%
Dec 31, 2025	BLACKROCK, INC.	3.01%	16.94K	1.48M	16.94K	+100.00%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.26%	12.73K	1.11M	12.73K	+100.00%
Dec 31, 2025	SUPERSTRING CAPITAL MANAGEMENT LP	2.16%	12.14K	1.06M	12.14K	+100.00%
Dec 31, 2025	STATE STREET CORP	1.14%	6.4K	557.5K	6.4K	+100.00%
Dec 31, 2025	RESOLUTE CAPITAL ASSET PARTNERS LLC	0.71%	4K	348.44K	4K	+100.00%
Dec 31, 2025	SKYVIEW INVESTMENT ADVISORS, LLC	0.53%	3K	261K	3K	+100.00%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.36%	2K	174.22K	2K	+100.00%
Dec 31, 2025	LION POINT CAPITAL, LP	0.18%	1K	87.11K	0	0
Dec 31, 2025	MORGAN STANLEY	0.07%	388	33.8K	290	+295.92%
Dec 31, 2025	SOUND INCOME STRATEGIES, LLC	0.04%	200	14.71K	200	+100.00%
Jun 30, 2025	IKARIAN CAPITAL, LLC	2.2%	1M	72.5K	0	0
Jun 30, 2025	TWO SIGMA ADVISERS, LP	0%	0	-	-12.2K	-100.00%
Jun 30, 2025	CARLYLE GROUP INC.	0%	0	-	-2.9M	-100.00%
Jun 30, 2025	JANE STREET GROUP, LLC	0%	0	-	-37.43K	-100.00%
Jun 30, 2025	ACADIAN ASSET MANAGEMENT LLC	2.3%	1.05M	74K	0	0
Jun 30, 2025	CITIGROUP INC	0%	0	-	-11.08K	-100.00%
Jun 30, 2025	VIRTU FINANCIAL LLC	0%	0	-	-39.43K	-100.00%
Jun 30, 2025	MORGAN STANLEY	0%	0	-	-7.4K	-100.00%
Jun 30, 2025	GROUND SWELL CAPITAL, LLC	0%	0	-	-17.31K	-100.00%
Jun 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0%	0	-	-2.61M	-100.00%
Jun 30, 2025	BLACKROCK, INC.	0%	0	-	-124.73K	-100.00%
Jun 30, 2025	JPMORGAN CHASE & CO	0%	0	-	-65	-100.00%
Jun 30, 2025	NORTHERN TRUST CORP	0%	0	-	-32.72K	-100.00%
Jun 30, 2025	GROUP ONE TRADING, L.P.	0%	0	-	-1.15K	-100.00%
Jun 30, 2025	CALDWELL SUTTER CAPITAL, INC.	0%	1K	73	0	0
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0%	0	-	-233	-100.00%
Jun 30, 2025	STATE STREET CORP	0%	0	-	-60.7K	-100.00%
Jun 30, 2025	VANGUARD GROUP INC	0%	0	-	-843.84K	-100.00%
Jun 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0%	0	-	-403.72K	-100.00%
Jun 30, 2025	XTX TOPCO LTD	0%	0	-	-41.22K	-100.00%
Jun 30, 2025	SHAY CAPITAL LLC	0%	0	-	-38.12K	-100.00%
Jun 30, 2025	LION POINT CAPITAL, LP	0%	0	-	-75K	-100.00%
Jun 30, 2025	UBS GROUP AG	0%	0	-	-116.46K	-100.00%
Jun 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0%	0	-	-288.8K	-100.00%
Jun 30, 2025	TOWER RESEARCH CAPITAL LLC (TRC)	0%	0	-	-4.7K	-100.00%
Jun 30, 2025	TWO SIGMA SECURITIES, LLC	0%	0	-	-47.69K	-100.00%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	0%	0	-	-276.71K	-100.00%
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0%	0	-	-382.9K	-100.00%
Jun 30, 2025	TWO SIGMA INVESTMENTS, LP	0%	0	-	-20.55K	-100.00%
Jun 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0%	0	-	-181	-100.00%
Mar 31, 2025	BLACKROCK, INC.	0.28%	124.73K	36.19K	0	0
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.87%	382.9K	111.08K	-23K	-5.67%
Mar 31, 2025	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0%	0	-	-34.9K	-100.00%
Mar 31, 2025	JPMORGAN CHASE & CO	0%	65	19	-4	-5.80%
Mar 31, 2025	SANDS CAPITAL VENTURES, LLC	0%	0	-	-715.82K	-100.00%
Mar 31, 2025	STATE STREET CORP	0.14%	60.7K	17.61K	0	0
Mar 31, 2025	TWO SIGMA SECURITIES, LLC	0.11%	47.69K	13.83K	47.69K	+100.00%
Mar 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0%	181	52	0	0
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0%	233	68	11	+4.96%
Mar 31, 2025	XTX TOPCO LTD	0.09%	41.22K	11.96K	5.67K	+15.94%
Mar 31, 2025	LION POINT CAPITAL, LP	0.17%	75K	21.76K	0	0
Mar 31, 2025	UBS GROUP AG	0.27%	116.46K	33.78K	30.42K	+35.35%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.63%	276.71K	80.29K	2.92K	+1.07%
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.92%	403.72K	117.12K	0	0
Mar 31, 2025	VANGUARD GROUP INC	1.92%	843.84K	244.72K	0	0
Mar 31, 2025	VIRTU FINANCIAL LLC	0.09%	39.43K	11K	39.43K	+100.00%
Mar 31, 2025	IKARIAN CAPITAL, LLC	2.28%	1M	290.1K	0	0
Mar 31, 2025	SIMPLEX TRADING, LLC	0%	0	-	-4.86K	-100.00%
Mar 31, 2025	ACADIAN ASSET MANAGEMENT LLC	2.38%	1.05M	301K	0	0
Mar 31, 2025	CARLYLE GROUP INC.	6.59%	2.9M	840.28K	0	0
Mar 31, 2025	GROUP ONE TRADING, L.P.	0%	1.15K	334	-616	-34.82%
Mar 31, 2025	MORGAN STANLEY	0.02%	7.4K	2.15K	5.26K	+246.74%
Mar 31, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.66%	288.8K	83.78K	0	0
Mar 31, 2025	CITIGROUP INC	0.03%	11.08K	3.22K	11.08K	+100.00%
Mar 31, 2025	NORTHERN TRUST CORP	0.07%	32.72K	9.49K	-47.59K	-59.26%
Mar 31, 2025	HRT FINANCIAL LP	0%	0	-	-37.84K	-100.00%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0%	0	-	-58.98K	-100.00%
Mar 31, 2025	JANE STREET GROUP, LLC	0.09%	37.43K	10.86K	37.43K	+100.00%
Mar 31, 2025	CALDWELL SUTTER CAPITAL, INC.	0%	1K	290	0	0
Mar 31, 2025	TOWER RESEARCH CAPITAL LLC (TRC)	0.01%	4.7K	1.36K	-64	-1.34%
Mar 31, 2025	TWO SIGMA ADVISERS, LP	0.03%	12.2K	3.54K	-1.6K	-11.59%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.05%	20.55K	5.96K	-71	-0.34%
Mar 31, 2025	SHAY CAPITAL LLC	0.09%	38.12K	11.06K	0	0
Mar 31, 2024	OMEGA FUND MANAGEMENT, LLC	0%	0	-	-2.16M	-100.00%
Mar 31, 2024	ALTIUM CAPITAL MANAGEMENT LP	2.8%	1.15M	903.79K	1.15M	+100.00%
Mar 31, 2024	PRIVIUM FUND MANAGEMENT (UK) LTD	0.06%	24.55K	20.13K	0	0
Mar 31, 2024	CARLYLE GROUP INC.	7.06%	2.9M	2.28M	0	0
Mar 31, 2024	ROCK SPRINGS CAPITAL MANAGEMENT LP	6.36%	2.61M	2.05M	0	0
Mar 31, 2024	ROSALIND ADVISORS, INC.	3.68%	1.51M	1.19M	-77.97K	-4.92%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	0.25%	102.22K	80.34K	-408.22K	-79.97%
Mar 31, 2024	XTX TOPCO LTD	0.14%	56.75K	44.6K	56.75K	+100.00%
Mar 31, 2024	ACADIAN ASSET MANAGEMENT LLC	0.9%	368.83K	289K	368.83K	+100.00%
Mar 31, 2024	ADAR1 CAPITAL MANAGEMENT, LLC	0.89%	365.22K	287.02K	365.22K	+100.00%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.66%	271K	213K	85.9K	+46.41%
Mar 31, 2024	PANAGORA ASSET MANAGEMENT INC	0.62%	253.68K	199.37K	253.68K	+100.00%
Mar 31, 2024	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.55%	224.83K	177K	224.83K	+100.00%
Mar 31, 2024	RIVERVEST VENTURE MANAGEMENT LLC	7.16%	2.94M	2.31M	0	0
Mar 31, 2024	VANGUARD GROUP INC	2.1%	863.38K	678.53K	40.99K	+4.98%
Mar 31, 2024	SANDS CAPITAL VENTURES, LLC	1.92%	787.01K	621.74K	0	0
Mar 31, 2024	SUPERSTRING CAPITAL MANAGEMENT LP	1.07%	440.23K	345.97K	321.41K	+270.52%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	0.49%	200.16K	157.34K	32.76K	+19.57%
Mar 31, 2024	AWM INVESTMENT COMPANY, INC.	0.49%	200K	157.18K	200K	+100.00%
Mar 31, 2024	BLACKROCK INC.	0.45%	185.95K	146.14K	-75.07K	-28.76%
Mar 31, 2024	WALLEYE CAPITAL LLC	0.44%	178.96K	140.64K	178.96K	+100.00%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.3%	123.01K	96.68K	-11.34K	-8.44%
Mar 31, 2024	TWO SIGMA ADVISERS, LP	0.22%	90.3K	70.97K	-5.3K	-5.54%
Mar 31, 2024	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.21%	85K	66.8K	0	0
Mar 31, 2024	JANE STREET GROUP, LLC	0.19%	78.54K	61.73K	78.54K	+100.00%
Mar 31, 2024	LION POINT CAPITAL, LP	0.18%	75K	58.94K	75K	+100.00%
Mar 31, 2024	NORTHERN TRUST CORP	0.18%	74.96K	58.91K	-21.73K	-22.48%
Mar 31, 2024	MARSHALL WACE, LLP	0.18%	72.25K	57.07K	-33.48K	-31.66%
Mar 31, 2024	STATE STREET CORP	0.16%	64.4K	50.61K	2.41K	+3.88%
Mar 31, 2024	CASTLEVIEW PARTNERS, LLC	0.15%	59.71K	46.93K	59.71K	+100.00%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	0.11%	46.66K	36.67K	46.66K	+100.00%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.1%	39.6K	27.72K	39.59K	+1,979,700.00%
Mar 31, 2024	CAPTION MANAGEMENT, LLC	0.1%	39.1K	30.73K	39.1K	+100.00%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.07%	29.71K	23.35K	29.71K	+100.00%
Mar 31, 2024	SIMPLEX TRADING, LLC	0.07%	28.1K	22K	28.1K	+100.00%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.06%	26.13K	20.51K	26.12K	+200,900.00%
Mar 31, 2024	TWO SIGMA SECURITIES, LLC	0.06%	26.02K	20.45K	26.02K	+100.00%
Mar 31, 2024	BELVEDERE TRADING LLC	0.06%	24.9K	19.57K	24.9K	+100.00%
Mar 31, 2024	BALYASNY ASSET MANAGEMENT L.P.	0.05%	22.51K	17.69K	22.51K	+100.00%
Mar 31, 2024	MORGAN STANLEY	0.05%	21.52K	16.92K	19.39K	+909.05%
Mar 31, 2024	OMERS ADMINISTRATION CORP	0.04%	16K	12.57K	16K	+100.00%
Mar 31, 2024	UBS GROUP AG	0.04%	15.81K	12.43K	15.33K	+3,160.62%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.04%	15.29K	12.02K	0	0
Mar 31, 2024	TOWER RESEARCH CAPITAL LLC (TRC)	0.03%	11.43K	8.98K	11.43K	+100.00%
Mar 31, 2024	CITADEL ADVISORS LLC	0.02%	9.9K	7.78K	9.9K	+100.00%
Mar 31, 2024	GROUP ONE TRADING, L.P.	0.01%	3.94K	3.1K	3.94K	+100.00%
Mar 31, 2024	CALDWELL SUTTER CAPITAL, INC.	0%	1K	786	0	0
Mar 31, 2024	WELLS FARGO & COMPANY/MN	0%	143	112	2	+1.42%
Mar 31, 2024	FMR LLC	0%	103	81	103	+100.00%
Mar 31, 2024	JPMORGAN CHASE & CO	0%	11	9	0	0
Mar 31, 2024	NOVO HOLDINGS A/S	0%	0	-	-6.72M	-100.00%
Mar 31, 2024	MARQUETTE ASSET MANAGEMENT, LLC	0%	0	-	-55.76K	-100.00%
Mar 31, 2024	ACUITAS INVESTMENTS, LLC	0%	0	-	-275.09K	-100.00%
Mar 31, 2024	AISLING CAPITAL MANAGEMENT LP	2.94%	1.21M	947.53K	0	0
Mar 31, 2024	WORTH VENTURE PARTNERS, LLC	0%	0	-	-526.93K	-100.00%
Mar 31, 2024	AIGH CAPITAL MANAGEMENT LLC	0%	0	-	-2.12M	-100.00%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	1.25%	510.44K	1.5M	-73.03K	-12.52%
Dec 31, 2023	WORTH VENTURE PARTNERS, LLC	1.29%	526.93K	1.54M	224.86K	+74.44%
Dec 31, 2023	DAFNA CAPITAL MANAGEMENT LLC	1.35%	548.51K	1.61M	-21.62K	-3.79%
Dec 31, 2023	SANDS CAPITAL VENTURES, LLC	1.93%	787.01K	2.31M	0	0
Dec 31, 2023	VANGUARD GROUP INC	2.02%	822.39K	2.41M	494.12K	+150.52%
Dec 31, 2023	AISLING CAPITAL MANAGEMENT LP	2.96%	1.21M	3.53M	0	0
Dec 31, 2023	ROSALIND ADVISORS, INC.	3.9%	1.59M	4.65M	1.59M	+100.00%
Dec 31, 2023	AIGH CAPITAL MANAGEMENT LLC	5.22%	2.12M	6.22M	912.86K	+75.38%
Dec 31, 2023	OMEGA FUND MANAGEMENT, LLC	5.31%	2.16M	6.33M	0	0
Dec 31, 2023	ARMISTICE CAPITAL, LLC	5.48%	2.23M	6.53M	-826K	-27.03%
Dec 31, 2023	5AM VENTURE MANAGEMENT, LLC	5.81%	2.36M	6.93M	0	0
Dec 31, 2023	ROCK SPRINGS CAPITAL MANAGEMENT LP	6.41%	2.61M	7.64M	-119K	-4.36%
Dec 31, 2023	CARLYLE GROUP INC.	7.11%	2.9M	8.37M	0	0
Dec 31, 2023	RIVERVEST VENTURE MANAGEMENT LLC	7.21%	2.94M	8.6M	0	0
Dec 31, 2023	NOVO HOLDINGS A/S	16.51%	6.72M	19.7M	0	0
Dec 31, 2023	TOWER RESEARCH CAPITAL LLC (TRC)	0%	0	-	-4.36K	-100.00%
Dec 31, 2023	VERITION FUND MANAGEMENT LLC	0%	0	-	-1.32M	-100.00%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0%	0	-	-89.12K	-100.00%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	0%	0	-	-32.45K	-100.00%
Dec 31, 2023	FMR LLC	0%	0	-	-36	-100.00%
Dec 31, 2023	QUBE RESEARCH & TECHNOLOGIES LTD	0%	2	6	2	+100.00%
Dec 31, 2023	JPMORGAN CHASE & CO	0%	11	32	0	0
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0%	13	38	-297	-95.81%
Dec 31, 2023	WELLS FARGO & COMPANY/MN	0%	141	413	11	+8.46%
Dec 31, 2023	UBS GROUP AG	0%	485	1.42K	472	+3,630.77%
Dec 31, 2023	CALDWELL SUTTER CAPITAL, INC.	0%	1K	2.93K	0	0
Dec 31, 2023	MORGAN STANLEY	0.01%	2.13K	6.25K	2	+0.09%
Dec 31, 2023	ROYAL BANK OF CANADA	0.02%	8.91K	26K	-744	-7.71%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.04%	15.29K	44.8K	0	0
Dec 31, 2023	SOFINNOVA INVESTMENTS, INC.	0.06%	22.77K	66.71K	-35.26K	-60.77%
Dec 31, 2023	PRIVIUM FUND MANAGEMENT (UK) LTD	0.06%	24.55K	71.94K	0	0
Dec 31, 2023	MARQUETTE ASSET MANAGEMENT, LLC	0.14%	55.76K	163.37K	0	0
Dec 31, 2023	STATE STREET CORP	0.15%	61.99K	181.64K	0	0
Dec 31, 2023	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.21%	85K	249.05K	0	0
Dec 31, 2023	TWO SIGMA ADVISERS, LP	0.23%	95.6K	280.11K	-700	-0.73%
Dec 31, 2023	NORTHERN TRUST CORP	0.24%	96.69K	283.3K	48.02K	+98.68%
Dec 31, 2023	MARSHALL WACE, LLP	0.26%	105.72K	309.76K	105.72K	+100.00%
Dec 31, 2023	CITADEL ADVISORS LLC	0.27%	108.24K	317.14K	33.21K	+44.26%
Dec 31, 2023		0.29%	118.81K	348.13K	118.81K	+100.00%
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	0.33%	134.36K	393.67K	-13K	-8.82%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	0.41%	167.4K	490.62K	0	0
Dec 31, 2023	RENAISSANCE TECHNOLOGIES LLC	0.45%	185.1K	542K	-22.68K	-10.91%
Dec 31, 2023	BLACKROCK INC.	0.64%	261.02K	764.78K	2.52K	+0.97%
Dec 31, 2023	ACUITAS INVESTMENTS, LLC	0.68%	275.09K	806K	84	+0.03%
Dec 31, 2023	ALYESKA INVESTMENT GROUP, L.P.	0.98%	400K	1.17M	-600K	-60.00%

Insiders

Among the SPRB insiders holding of 8.68% of the stake in company, NOVO HOLDINGS A/S, 10 percent owner, holds the largest shares of 2.55M. CHAYA MOGHRABI DINA, director, is the second largest SPRB insider with ownership of 2.16M shares. OMEGA FUND VI, L.P., , stands third with possession of 2.16M shares of that stake.

Insiders	Designation	Shares Held
NOVO HOLDINGS A/S	10 percent owner	2.55M
CHAYA MOGHRABI DINA	director	2.16M
OMEGA FUND VI, L.P.		2.16M
RIVERVEST VENTURE FUND III, L.P.	10 percent owner	2.15M
HEALTHCAP VIII, L.P.		2.03M
HANSSON JONAS	director	2.03M
MURALIDHAR BALI	director	1.79M
O'DONNELL NIALL	director	472.8K
PARKMAN HEALTHCARE PARTNERS LLC	10 percent owner	1.05K
SIMPSON CAMILLA V	director	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Oct 06, 2025	PARKMAN HEALTHCARE PARTNERS LLC	SALE	17.46	25	436.39	1.05K
Mar 21, 2024	NOVO HOLDINGS A/S	SALE	0.75	465.02K	350.95K	2.55M
Mar 20, 2024	NOVO HOLDINGS A/S	SALE	0.73	359.98K	264.08K	3.02M
Mar 19, 2024	NOVO HOLDINGS A/S	SALE	0.76	593K	447.72K	3.38M
Mar 18, 2024	NOVO HOLDINGS A/S	SALE	0.77	842.02K	647.01K	3.97M
Mar 14, 2024	NOVO HOLDINGS A/S	SALE	0.89	1.91M	1.7M	4.81M
Feb 16, 2023	NOVO HOLDINGS A/S	PURCHASE	3.96	1.66M	6.56M	1.66M
Feb 16, 2023	O'DONNELL NIALL	PURCHASE	3.96	472.8K	1.87M	472.8K
May 20, 2021	SIMPSON CAMILLA V	SALE	15.29	334	5.11K	0
May 19, 2021	NOVO HOLDINGS A/S	SALE	13.90	475K	6.6M	4.51M
Apr 30, 2021	SIMPSON CAMILLA V	SALE	16.14	14.05K	226.66K	0
Oct 14, 2020	HEALTHCAP VIII, L.P.	PURCHASE	15.00	250K	3.75M	2.03M
Oct 14, 2020	NOVO HOLDINGS A/S	PURCHASE	15.00	250K	3.75M	4.99M
Oct 14, 2020	RIVERVEST VENTURE FUND III, L.P.	PURCHASE	15.00	250K	3.75M	2.15M
Oct 14, 2020	MURALIDHAR BALI	PURCHASE	15.00	200K	3M	1.79M
Oct 14, 2020	O'DONNELL NIALL	PURCHASE	15.00	250K	3.75M	695.91K
Oct 14, 2020	OMEGA FUND VI, L.P.	PURCHASE	15.00	250K	3.75M	2.16M
Oct 14, 2020	CHAYA MOGHRABI DINA	PURCHASE	15.00	250K	3.75M	2.16M
Oct 14, 2020	HANSSON JONAS	PURCHASE	15.00	250K	3.75M	2.03M

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES251

NET SHARES-251

SHARES HELD1.05K1

% NET SHARES-102.38%0%

Frequently Asked Questions