How many institutions own SNDX stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own SNDX shares is 321, representing 120.17% of the company's common stock.

Who are the major shareholders selling Syndax Pharmaceuticals, Inc. stock?

BLACKROCK, INC., in the last quarter, reduced its stake in SNDX by -4.48% restricting it's holding to 8.24 million shares of worth nearly $173.10M. BARCLAYS PLC also lessened -9.59% of the SNDX shares from its portfolio, reducing its holding to 314.67 thousand shares of worth $6.61M. KNOTT DAVID M JR also shunned SNDX shares holding by -3.04% last quarter which brought its holding to 415 thousand shares worth $8.72M.

Investors who are buying SNDX stock?

As per its latest 13F filing, TWO SIGMA ADVISERS, LP increased its stake in SNDX by 65.19% in the last quarter. The institutional holder raised its holding to 632.75 thousand shares having worth more than $13.29M. AQR CAPITAL MANAGEMENT LLC also added 65.92% more shares of SNDX to its portfolio, raising its holding to 925.97 thousand shares of worth $19.45M. TWO SIGMA INVESTMENTS, LP also increased its SNDX shares holding by 60.94% which brought its holding to 1.15 million shares worth $24.10M.

SNDX's major insiders: who are they?

The insider with the most stakes in SNDX is ROYSTON IVOR , director at the company. Additionally, SNDX stock is highly held by Chief Executive Officer Metzger Michael A and director Podlesak Dennis among others.

Did an insider recently sell SNDX stock?

Company executives, directors, and other insiders own 1.28% percent of Syndax Pharmaceuticals, Inc.'s stock. Within the last six months, there have been 5 transaction(s) in which SNDX insiders have sold stock, totaling 187.37K shares. Insiders that have sold shares include METZGER MICHAEL A, GOLDAN KEITH A., and PODLESAK DENNIS.

Which insider recently purchased SNDX stock?

There have been 0 transaction(s) during the past 6-months in which Syndax Pharmaceuticals, Inc. insiders have bought stock, totalling 0 shares

How much of SNDX does insiders own?

Around 1.58M Syndax Pharmaceuticals, Inc. shares are held by insiders, which represents about 1.28% of SNDX stock.

Who is the insider with the largest stake?

SNDX director, ROYSTON IVOR holds the largest portfolio of the company's shares. SNDX shares owned by ROYSTON total nearly 750.55 thousand.

Which institution holds the most shares in SNDX?

BLACKROCK, INC. is the largest institutional owner in SNDX which holds 8.24 million shares worth $173.10M or 9.51% of the total SNDX shares outstanding followed by BARCLAYS PLC with ownership of 314.67 thousand shares representing 0.36% of the SNDX ownership. ABRDN PLC is the third largest stakeholder with 372.79 thousand shares or 0.43% of the ownership worth more than $7.83M.

Is Syndax Pharmaceuticals, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the SNDX is concerned, it is a stock which is optionable.

Is there a short position on SNDX's shares?

Number of SNDX shares short is 20.61M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding SNDX shares are there?

As of today, 86.14M shares of SNDX are outstanding.

Is there many float in SNDX stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, SNDX has 72.72M shares in float.

SNDX short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for SNDX is 7.76.

Syndax Pharmaceuticals (SNDX) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares23.92

Short Percent Of Float27.01

Shares Outstanding86.14M

Shares Float72.72M

Shares Short20.61M

Short Ratio7.76

27.01%

Short % of Float

23.92%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

1.28% Percentage of Shares held by All Insiders

120.17% Percentage of Shares held by All Institutions

121.72% Percentage of Float held by Institutions

321

Number of Institutions Holding Shares

Institutional Ownership

About 120.17% of SNDX shares are held by financial institutions. BLACKROCK, INC. is the top corporate investor, holding 8.24M shares valued at $173.10M. A 9.51% stake in Syndax Pharmaceuticals, Inc. is owned by the company. BARCLAYS PLC owns 314.67K shares valued at $6.61M, which translates its holding of 0.36% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	BLACKROCK, INC.	9.51%	8.24M	173.1M	-386.24K	-4.48%
Dec 31, 2025	BARCLAYS PLC	0.36%	314.67K	6.61M	-33.39K	-9.59%
Dec 31, 2025	ABRDN PLC	0.43%	372.79K	7.83M	0	0
Dec 31, 2025	KNOTT DAVID M JR	0.48%	415K	8.72M	-13K	-3.04%
Dec 31, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.56%	487K	10.23M	-87K	-15.16%
Dec 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.63%	544.8K	11.45M	-315.7K	-36.69%
Dec 31, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.66%	574.02K	12.06M	-272.88K	-32.22%
Dec 31, 2025	TWO SIGMA ADVISERS, LP	0.73%	632.75K	13.29M	249.7K	+65.19%
Dec 31, 2025	UBS GROUP AG	0.83%	716.22K	15.05M	-958.29K	-57.23%
Dec 31, 2025	AQR CAPITAL MANAGEMENT LLC	1.07%	925.97K	19.45M	367.9K	+65.92%
Dec 31, 2025	TWO SIGMA INVESTMENTS, LP	1.32%	1.15M	24.1M	434.28K	+60.94%
Dec 31, 2025	BIOIMPACT CAPITAL LLC	1.54%	1.34M	28.11M	-37.97K	-2.76%
Dec 31, 2025	KINGDON CAPITAL MANAGEMENT, L.L.C.	2.71%	2.35M	49.37M	-150K	-6.00%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	5.44%	4.71M	98.97M	1.01M	+27.39%
Dec 31, 2025	CAPTION MANAGEMENT, LLC	0.49%	424.5K	8.92M	-194.3K	-31.40%
Dec 31, 2025	BREVAN HOWARD CAPITAL MANAGEMENT LP	0.59%	515.13K	10.82M	390.55K	+313.51%
Dec 31, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.64%	554.76K	11.66M	482.3K	+665.57%
Dec 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.79%	688.14K	14.46M	-956.71K	-58.16%
Dec 31, 2025	APIS CAPITAL ADVISORS, LLC	0.84%	724K	15.21M	86K	+13.48%
Dec 31, 2025	NORTHERN TRUST CORP	0.84%	728.92K	15.31M	-47.77K	-6.15%
Dec 31, 2025	Y-INTERCEPT (HONG KONG) LTD	0.18%	155.92K	3.28M	55.07K	+54.60%
Dec 31, 2025	SEI INVESTMENTS CO	0.18%	159.64K	3.35M	116.19K	+267.42%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.19%	160.85K	3.38M	103.93K	+182.61%
Dec 31, 2025	SWISS NATIONAL BANK	0.19%	161.4K	3.39M	2.9K	+1.83%
Dec 31, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.19%	161.94K	3.4M	20.12K	+14.19%
Dec 31, 2025	JUMP FINANCIAL, LLC	0.19%	163.92K	3.44M	31.21K	+23.52%
Dec 31, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.19%	165K	3.47M	-85K	-34.00%
Dec 31, 2025	MACQUARIE MANAGEMENT HOLDINGS, INC.	0.21%	180K	3.78B	180K	+100.00%
Dec 31, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.21%	183.8K	3.86M	129.1K	+236.03%
Dec 31, 2025	CITADEL ADVISORS LLC	0.21%	184K	3.87B	-362.27K	-66.32%
Dec 31, 2025	CAPITAL FUND MANAGEMENT S.A.	0.27%	233.87K	4.91M	-107.32K	-31.46%
Dec 31, 2025	SECTOR GAMMA AS	0.29%	252.06K	5.3M	41.25K	+19.57%
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.5%	434.1K	9.12M	21.1K	+5.11%
Dec 31, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.32%	277.86K	5.84M	-222.85K	-44.51%
Dec 31, 2025	PALE FIRE CAPITAL SE	0.33%	284.46K	5.98M	284.46K	+100.00%
Dec 31, 2025	SPHERA FUNDS MANAGEMENT LTD.	0.88%	762.56K	16.02M	374.85K	+96.68%
Dec 31, 2025	WOODLINE PARTNERS LP	1.44%	1.25M	26.28M	-299.85K	-19.34%
Dec 31, 2025	STEMPOINT CAPITAL LP	1.55%	1.34M	28.14M	-26.83K	-1.96%
Dec 31, 2025		2.14%	1.86M	38.97B	1.86M	+100.00%
Dec 31, 2025	HOOD RIVER CAPITAL MANAGEMENT LLC	2.67%	2.32M	48.67M	2.32M	+100.00%
Dec 31, 2025	EVERSEPT PARTNERS, LP	3.83%	3.31M	69.64M	-152.91K	-4.41%
Dec 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	5.64%	4.88M	102.57M	627.01K	+14.74%
Dec 31, 2025	KYNAM CAPITAL MANAGEMENT, LP	9.29%	8.05M	169.15M	-469.04K	-5.51%
Dec 31, 2025	STIFEL FINANCIAL CORP	0.09%	75.91K	1.59M	-22.43K	-22.81%
Dec 31, 2025	LEGAL & GENERAL GROUP PLC	0.09%	78.24K	1.64M	-6.31K	-7.46%
Dec 31, 2025	TORRAY INVESTMENT PARTNERS LLC	0.11%	97.8K	2.05M	97.8K	+100.00%
Dec 31, 2025	IEQ CAPITAL, LLC	0.12%	99.88K	2.1M	44.67K	+80.92%
Dec 31, 2025	TEMA ETFS LLC	0.12%	100.05K	2.1M	-10.01K	-9.10%
Dec 31, 2025	YELIN LAPIDOT HOLDINGS MANAGEMENT LTD.	0.13%	108.38K	2.28M	0	0
Dec 31, 2025	MORGAN STANLEY	1.24%	1.08M	22.6M	-123.8K	-10.32%
Dec 31, 2025	EVENTIDE ASSET MANAGEMENT, LLC	1.43%	1.24M	26.01M	249.71K	+25.26%
Dec 31, 2025	AISLING CAPITAL MANAGEMENT LP	1.52%	1.32M	27.67M	0	0
Dec 31, 2025	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	1.59%	1.38M	28.9M	139.6K	+11.29%
Dec 31, 2025	NUVEEN, LLC	1.71%	1.48M	31.16M	7.2K	+0.49%
Dec 31, 2025	ENSIGN PEAK ADVISORS, INC	1.85%	1.6M	33.59M	789.48K	+97.58%
Dec 31, 2025	VOSS CAPITAL, LLC	0.14%	125K	2.63M	125K	+100.00%
Dec 31, 2025	PANAGORA ASSET MANAGEMENT INC	0.14%	125.1K	2.63M	-30.22K	-19.46%
Dec 31, 2025	SG AMERICAS SECURITIES, LLC	0.15%	129.23K	2.72M	83.8K	+184.48%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.41%	2.09M	43.94M	-399	-0.02%
Dec 31, 2025	CATALIO CAPITAL MANAGEMENT, LP	1.38%	1.2M	25.14M	-417.91K	-25.88%
Dec 31, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	2.59%	2.25M	47.21M	235K	+11.68%
Dec 31, 2025	VELAN CAPITAL INVESTMENT MANAGEMENT LP	0.15%	130K	2.73M	0	0
Dec 31, 2025	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	0.16%	137.63K	2.89M	137.63K	+100.00%
Dec 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.16%	142.41K	2.99M	8.15K	+6.07%
Dec 31, 2025	VIENNA POWSZECHNE TOWARZYSTWO EMERYTALNE S.A. VIENNA INSURANCE GROUP	0.23%	200K	4.2M	0	0
Dec 31, 2025	JPMORGAN CHASE & CO	0.44%	378.5K	7.95M	124.65K	+49.11%
Dec 31, 2025	D. E. SHAW & CO., INC.	1.41%	1.22M	25.62M	142.02K	+13.18%
Dec 31, 2025	FRANKLIN RESOURCES INC	2.8%	2.42M	50.88M	31.11K	+1.30%
Dec 31, 2025	STATE STREET CORP	5.31%	4.6M	96.57M	743K	+19.28%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	6.58%	5.7M	119.66M	208.94K	+3.81%
Dec 31, 2025	VANGUARD GROUP INC	7.19%	6.23M	130.9M	1.09M	+21.25%
Dec 31, 2025	RHUMBLINE ADVISERS	0.14%	118.8K	2.5M	-12.87K	-9.77%
Dec 31, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.74%	642.9K	13.51M	179.19K	+38.64%
Dec 31, 2025	PROSIGHT MANAGEMENT, LP	0.77%	665K	13.97M	-338.4K	-33.73%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.84%	727.42K	15.28M	8.39K	+1.17%
Dec 31, 2025	JANE STREET GROUP, LLC	0.86%	748.92K	15.73M	10.65K	+1.44%
Dec 31, 2025	PALO ALTO INVESTORS LP	0.92%	794.51K	16.69M	139.58K	+21.31%
Dec 31, 2025	CANDRIAM S.C.A.	1.07%	925.33K	19.44M	0	0
Dec 31, 2025	ALGERT GLOBAL LLC	1.07%	928.09K	19.5M	-2.68K	-0.29%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	1.26%	1.09M	22.99M	41.82K	+3.97%
Sep 30, 2025	ABRDN PLC	0.43%	372.79K	5.74M	69.37K	+22.86%
Sep 30, 2025	TWO SIGMA ADVISERS, LP	0.44%	383.05K	5.89M	-9.4K	-2.40%
Sep 30, 2025	ZIMMER PARTNERS, LP	0.44%	383.1K	5.89M	-222.7K	-36.76%
Sep 30, 2025	SPHERA FUNDS MANAGEMENT LTD.	0.45%	387.72K	5.97M	-1.18M	-75.33%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.42%	2.09M	32.18M	41.98K	+2.05%
Sep 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.65%	558.08K	8.59M	327.5K	+142.03%
Sep 30, 2025	EVERSEPT PARTNERS, LP	4.02%	3.47M	53.34M	-598.04K	-14.71%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	4.28%	3.7M	56.89M	-141.12K	-3.68%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	1.21%	1.05M	16.1M	-552.16K	-34.54%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	1.22%	1.05M	16.19M	815.23K	+343.83%
Sep 30, 2025	D. E. SHAW & CO., INC.	1.25%	1.08M	16.58M	433.04K	+67.19%
Sep 30, 2025	MORGAN STANLEY	1.39%	1.2M	18.45M	350.06K	+41.22%
Sep 30, 2025	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	1.43%	1.24M	19.02M	-209.36K	-14.48%
Sep 30, 2025	CITADEL ADVISORS LLC	0.63%	546.27K	8.4M	-93.73K	-14.65%
Sep 30, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.66%	574K	8.83M	0	0
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.69%	599.87K	9.23M	99.97K	+20.00%
Sep 30, 2025	ENSIGN PEAK ADVISORS, INC	0.94%	809.06K	12.45M	120K	+17.41%
Sep 30, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.98%	846.9K	13.03M	-20.91K	-2.41%
Sep 30, 2025	AISLING CAPITAL MANAGEMENT LP	1.53%	1.32M	20.27M	0	0
Sep 30, 2025	STEMPOINT CAPITAL LP	1.58%	1.37M	21.02M	-1.01M	-42.42%
Sep 30, 2025	BIOIMPACT CAPITAL LLC	1.59%	1.38M	21.16M	1.38M	+100.00%
Sep 30, 2025	HSBC HOLDINGS PLC	0.07%	56.52K	884.04K	-50.26K	-47.07%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.07%	56.92K	875.65K	-97.49K	-63.14%
Sep 30, 2025	QUEST PARTNERS LLC	0.07%	59.34K	912.96K	38.39K	+183.29%
Sep 30, 2025	DEUTSCHE BANK AG\	0.08%	72.47K	1.12M	7.7K	+11.89%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.09%	79.54K	1.22M	-46.62K	-36.95%
Sep 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.1%	83.21K	1.28M	-7.65K	-8.42%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.1%	84.55K	1.3M	-29	-0.03%
Sep 30, 2025	STIFEL FINANCIAL CORP	0.11%	98.34K	1.51M	9.24K	+10.37%
Sep 30, 2025	Y-INTERCEPT (HONG KONG) LTD	0.12%	100.85K	1.55M	-176.08K	-63.58%
Sep 30, 2025	YELIN LAPIDOT HOLDINGS MANAGEMENT LTD.	0.13%	108.38K	1.67M	0	0
Sep 30, 2025	TEMA ETFS LLC	0.13%	110.07K	1.69M	23.77K	+27.54%
Sep 30, 2025	NEOS INVESTMENT MANAGEMENT LLC	0.13%	110.07K	1.69M	23.77K	+27.54%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.14%	121.47K	1.87M	-366.18K	-75.09%
Sep 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.14%	123.4K	1.92M	1.24K	+1.02%
Sep 30, 2025	RHUMBLINE ADVISERS	0.15%	131.67K	2.03M	2.94K	+2.28%
Sep 30, 2025	JUMP FINANCIAL, LLC	0.15%	132.7K	2.04M	-248.33K	-65.17%
Sep 30, 2025	INVESCO LTD.	0.15%	133.09K	2.05M	27.93K	+26.56%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.16%	141.82K	2.18M	15.78K	+12.52%
Sep 30, 2025	KEYBANK NATIONAL ASSOCIATION/OH	0.17%	150K	2.31M	150K	+100.00%
Sep 30, 2025	PANAGORA ASSET MANAGEMENT INC	0.18%	155.32K	2.39M	155.32K	+100.00%
Sep 30, 2025	SWISS NATIONAL BANK	0.18%	158.5K	2.44M	-5.8K	-3.53%
Sep 30, 2025	MACQUARIE GROUP LTD	0.21%	180K	2.77M	0	0
Sep 30, 2025	VIENNA POWSZECHNE TOWARZYSTWO EMERYTALNE S.A. VIENNA INSURANCE GROUP	0.23%	200K	3.08M	0	0
Sep 30, 2025	SECTOR GAMMA AS	0.24%	210.81K	3.24M	210.81K	+100.00%
Sep 30, 2025	CANADA PENSION PLAN INVESTMENT BOARD	0.27%	229.6K	3.53M	229.6K	+100.00%
Sep 30, 2025	MARSHALL WACE, LLP	0.27%	233.97K	3.6M	1.85K	+0.80%
Sep 30, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.29%	250K	3.85M	-193.3K	-43.60%
Sep 30, 2025	JPMORGAN CHASE & CO	0.29%	253.85K	3.91M	-19.02K	-6.97%
Sep 30, 2025	STATE STREET CORP	4.46%	3.85M	59.29M	410.8K	+11.93%
Sep 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	4.93%	4.26M	65.46M	2.13M	+100.01%
Sep 30, 2025	VANGUARD GROUP INC	5.95%	5.14M	79.06M	104.68K	+2.08%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	6.35%	5.49M	84.41M	-310.76K	-5.36%
Sep 30, 2025	GRANAHAN INVESTMENT MANAGEMENT, LLC	0.46%	396.34K	6.1M	-595.05K	-60.02%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.48%	413K	6.36M	244.3K	+144.81%
Sep 30, 2025	KNOTT DAVID M JR	0.5%	428K	6.58M	75.22K	+21.32%
Sep 30, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.54%	463.71K	7.13M	60.74K	+15.07%
Sep 30, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.58%	500.7K	7.7M	-42.9K	-7.89%
Sep 30, 2025	CAPTION MANAGEMENT, LLC	0.72%	618.8K	9.52M	129.9K	+26.57%
Sep 30, 2025	APIS CAPITAL ADVISORS, LLC	0.74%	638K	9.82M	638K	+100.00%
Sep 30, 2025	PALO ALTO INVESTORS LP	0.76%	654.93K	10.08M	210.56K	+47.38%
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.83%	712.66K	10.96M	155.69K	+27.95%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.83%	719.03K	11.06M	6.72K	+0.94%
Sep 30, 2025	JANE STREET GROUP, LLC	0.86%	738.27K	11.36M	570.77K	+340.77%
Sep 30, 2025	NORTHERN TRUST CORP	0.9%	776.69K	11.95M	6.24K	+0.81%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	1%	860.5K	13.24M	22.8K	+2.72%
Sep 30, 2025	CANDRIAM S.C.A.	1.07%	925.33K	14.24M	250.25K	+37.07%
Sep 30, 2025	ALGERT GLOBAL LLC	1.08%	930.77K	14.32M	-90.51K	-8.86%
Sep 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	1.14%	988.49K	15.21M	-425.6K	-30.10%
Sep 30, 2025	PROSIGHT MANAGEMENT, LP	1.16%	1M	15.44M	-76.27K	-7.06%
Sep 30, 2025	NUVEEN, LLC	1.71%	1.48M	22.71M	1.21M	+454.72%
Sep 30, 2025	WOODLINE PARTNERS LP	1.8%	1.55M	23.85M	-342.23K	-18.08%
Sep 30, 2025	CATALIO CAPITAL MANAGEMENT, LP	1.87%	1.61M	24.84M	-489.8K	-23.27%
Sep 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	1.91%	1.64M	25.31M	-21.07K	-1.26%
Sep 30, 2025	UBS GROUP AG	1.94%	1.67M	25.76M	239.1K	+16.66%
Sep 30, 2025	ASSENAGON ASSET MANAGEMENT S.A.	2.07%	1.78M	27.45M	-255.85K	-12.54%
Sep 30, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	2.33%	2.01M	30.96M	920K	+84.24%
Sep 30, 2025	FRANKLIN RESOURCES INC	2.77%	2.39M	36.78M	30.88K	+1.31%
Sep 30, 2025	KINGDON CAPITAL MANAGEMENT, L.L.C.	2.9%	2.5M	38.46M	400K	+19.05%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	3.84%	3.31M	50.95M	1.88M	+131.21%
Sep 30, 2025	KYNAM CAPITAL MANAGEMENT, LP	9.87%	8.52M	131.08M	0	0
Sep 30, 2025	BLACKROCK, INC.	9.99%	8.63M	132.7M	-1.83M	-17.52%
Sep 30, 2025	CAPITAL FUND MANAGEMENT S.A.	0.4%	341.19K	5.25M	162.91K	+91.37%
Sep 30, 2025	BARCLAYS PLC	0.4%	348.06K	5.35M	-34.91K	-9.11%
Jun 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.14%	122.16K	1.14M	64.6K	+112.22%
Jun 30, 2025	WOODLINE PARTNERS LP	2.19%	1.89M	17.73M	948	+0.05%
Jun 30, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.66%	574K	5.38M	141K	+32.56%
Jun 30, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.63%	543.6K	5.09M	-900	-0.17%
Jun 30, 2025	KNOTT DAVID M JR	0.41%	352.78K	3.3M	224.78K	+175.61%
Jun 30, 2025	AVIDITY PARTNERS MANAGEMENT LP	0.39%	340K	3.18M	-60K	-15.00%
Jun 30, 2025	ABRDN PLC	0.35%	303.43K	2.84M	170.99K	+129.12%
Jun 30, 2025	Y-INTERCEPT (HONG KONG) LTD	0.32%	276.93K	2.59M	276.93K	+100.00%
Jun 30, 2025	ENGINEERS GATE MANAGER LP	0.21%	179.28K	1.68M	52.79K	+41.74%
Jun 30, 2025	DARK FOREST CAPITAL MANAGEMENT LP	0.19%	160.33K	1.5M	121.12K	+308.90%
Jun 30, 2025	ASSENAGON ASSET MANAGEMENT S.A.	2.36%	2.04M	19.1M	0	0
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	1.85%	1.6M	14.97M	1.17M	+272.94%
Jun 30, 2025	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	1.67%	1.45M	13.54M	224.17K	+18.36%
Jun 30, 2025	ALGERT GLOBAL LLC	1.18%	1.02M	9.56M	136.68K	+15.45%
Jun 30, 2025	BARCLAYS PLC	0.44%	382.97K	3.59M	182.98K	+91.49%
Jun 30, 2025	VANGUARD GROUP INC	5.83%	5.03M	47.14M	162.87K	+3.34%
Jun 30, 2025	SOFINNOVA INVESTMENTS, INC.	1.77%	1.52M	14.28M	-750.78K	-33.00%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.66%	1.43M	13.41M	800.8K	+126.78%
Jun 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	1.64%	1.41M	13.24M	236.02K	+20.03%
Jun 30, 2025	AISLING CAPITAL MANAGEMENT LP	1.53%	1.32M	12.33M	291.81K	+28.47%
Jun 30, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	1.26%	1.09M	10.23M	275.5K	+33.74%
Jun 30, 2025	PROSIGHT MANAGEMENT, LP	1.25%	1.08M	10.11M	470.42K	+77.21%
Jun 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.58%	499.9K	4.68M	282.91K	+130.38%
Jun 30, 2025	SATURN V CAPITAL MANAGEMENT LLC	0.58%	500.55K	4.69M	-540.73K	-51.93%
Jun 30, 2025	CAPTION MANAGEMENT, LLC	0.57%	488.9K	4.58M	238.9K	+95.56%
Jun 30, 2025	BLACKROCK, INC.	12.11%	10.46M	97.93M	1.91M	+22.41%
Jun 30, 2025	KYNAM CAPITAL MANAGEMENT, LP	9.87%	8.52M	79.79M	0	0
Jun 30, 2025	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	0.18%	155K	1.45M	-95K	-38.00%
Jun 30, 2025	STATE OF WISCONSIN INVESTMENT BOARD	0.16%	141.11K	1.32M	77.01K	+120.12%
Jun 30, 2025	HRT FINANCIAL LP	0.15%	127.11K	1.19M	-17.92K	-12.36%
Jun 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.15%	126.05K	1.18M	-45.5K	-26.52%
Jun 30, 2025	VERITION FUND MANAGEMENT LLC	0.15%	125.35K	1.17M	90.31K	+257.75%
Jun 30, 2025	TWINBEECH CAPITAL LP	0.13%	112.79K	1.06M	-143.04K	-55.91%
Jun 30, 2025	YELIN LAPIDOT HOLDINGS MANAGEMENT LTD.	0.13%	108.38K	1.01M	0	0
Jun 30, 2025	POLAR ASSET MANAGEMENT PARTNERS INC.	0.11%	97.11K	909.46K	-9.52K	-8.92%
Jun 30, 2025	STONEPINE CAPITAL MANAGEMENT, LLC	0.11%	92.9K	870.01K	92.9K	+100.00%
Jun 30, 2025	EVERSEPT PARTNERS, LP	4.71%	4.07M	38.07M	-146.92K	-3.49%
Jun 30, 2025	VIENNA POWSZECHNE TOWARZYSTWO EMERYTALNE S.A. VIENNA INSURANCE GROUP	0.23%	200K	1.87M	0	0
Jun 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	1.93%	1.67M	15.6M	831.07K	+99.55%
Jun 30, 2025	SPHERA FUNDS MANAGEMENT LTD.	1.82%	1.57M	14.72M	-92.41K	-5.55%
Jun 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	0.87%	754.5K	7.07M	200K	+36.07%
Jun 30, 2025	ENSIGN PEAK ADVISORS, INC	0.8%	689.06K	6.45M	0	0
Jun 30, 2025	CANDRIAM S.C.A.	0.78%	675.09K	6.32M	224.65K	+49.87%
Jun 30, 2025	CASDIN CAPITAL, LLC	0.75%	650K	6.08M	15K	+2.36%
Jun 30, 2025	D. E. SHAW & CO., INC.	0.75%	644.54K	6.04B	-143.05K	-18.16%
Jun 30, 2025	ZIMMER PARTNERS, LP	0.7%	605.8K	5.67M	392.64K	+184.20%
Jun 30, 2025	TANG CAPITAL MANAGEMENT LLC	0.23%	200K	1.87M	0	0
Jun 30, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.51%	443.3K	4.15M	193.3K	+77.32%
Jun 30, 2025	JUMP FINANCIAL, LLC	0.44%	381.04K	3.57M	381.04K	+100.00%
Jun 30, 2025	ROYAL BANK OF CANADA	0.41%	351.26K	3.29M	349.34K	+18,185.42%
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.31%	264.74K	2.48M	218.35K	+470.63%
Jun 30, 2025	MARSHALL WACE, LLP	0.27%	232.12K	2.17M	232.12K	+100.00%
Jun 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.27%	230.58K	2.16B	-146.87K	-38.91%
Jun 30, 2025	MAN GROUP PLC	0.26%	228.17K	2.14M	94.03K	+70.10%
Jun 30, 2025	WALLEYE CAPITAL LLC	0.26%	226.02K	2.12M	-101.12K	-30.91%
Jun 30, 2025	GRANAHAN INVESTMENT MANAGEMENT, LLC	1.15%	991.39K	9.28M	441.45K	+80.27%
Jun 30, 2025	PARKMAN HEALTHCARE PARTNERS LLC	1.01%	867.81K	8.13M	272.83K	+45.85%
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.97%	837.7K	7.85M	156.27K	+22.93%
Jun 30, 2025	NORTHERN TRUST CORP	0.89%	770.45K	7.22M	-8.31K	-1.07%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.83%	712.31K	6.67M	22.62K	+3.28%
Jun 30, 2025	TWO SIGMA INVESTMENTS, LP	0.65%	556.97K	5.22M	-223.04K	-28.59%
Jun 30, 2025	TWO SIGMA ADVISERS, LP	0.45%	392.45K	3.68M	-110.7K	-22.00%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.56%	487.65K	4.57M	21.77K	+4.67%
Jun 30, 2025	PALO ALTO INVESTORS LP	0.51%	444.37K	4.16M	0	0
Jun 30, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.47%	402.96K	3.77M	-906.26K	-69.22%
Jun 30, 2025	STEMPOINT CAPITAL LP	2.75%	2.37M	22.22M	774.04K	+48.42%
Jun 30, 2025	FRANKLIN RESOURCES INC	2.73%	2.36M	22.1M	298.27K	+14.47%
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	2.46%	2.13M	19.92M	-1.88M	-46.93%
Jun 30, 2025		2.44%	2.1M	19.71M	370.81K	+21.39%
Jun 30, 2025	KINGDON CAPITAL MANAGEMENT, L.L.C.	2.43%	2.1M	19.67M	100K	+5.00%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.37%	2.05M	19.19M	26.37K	+1.30%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	6.71%	5.8M	54.29B	1.88M	+47.83%
Jun 30, 2025	MORGAN STANLEY	0.98%	849.24K	7.95B	-1.43M	-62.78%
Jun 30, 2025	CITADEL ADVISORS LLC	0.74%	640K	5.99B	-2.27M	-78.04%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	4.45%	3.84M	35.95M	967.87K	+33.71%
Jun 30, 2025	STATE STREET CORP	3.99%	3.44M	32.24M	-528.98K	-13.32%
Jun 30, 2025	UBS GROUP AG	1.66%	1.44M	13.44M	-280.36K	-16.34%
Jun 30, 2025	CATALIO CAPITAL MANAGEMENT, LP	2.44%	2.1M	19.71M	370.81K	+21.39%
Mar 31, 2025	ENSIGN PEAK ADVISORS, INC	0.8%	689.06K	8.47M	421.12K	+157.16%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	3.35%	2.87M	35.27M	2.63M	+1,069.41%
Mar 31, 2025	FRANKLIN RESOURCES INC	2.41%	2.06M	25.32M	294.55K	+16.67%
Mar 31, 2025	CITADEL ADVISORS LLC	3.4%	2.91M	35.81M	1.83M	+167.47%
Mar 31, 2025	NORTHERN TRUST CORP	0.91%	778.76K	9.57M	-13.99K	-1.77%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.91%	780.01K	9.58M	110.19K	+16.45%
Mar 31, 2025	D. E. SHAW & CO., INC.	0.92%	787.59K	9.68M	603.47K	+327.76%
Mar 31, 2025	CASDIN CAPITAL, LLC	0.74%	635K	7.8M	160K	+33.68%
Mar 31, 2025	BLACKROCK, INC.	9.98%	8.54M	104.94M	-491.7K	-5.44%
Mar 31, 2025	UBS GROUP AG	2%	1.72M	21.08M	686.96K	+66.77%
Mar 31, 2025	SOFINNOVA INVESTMENTS, INC.	2.66%	2.28M	27.95M	1.62M	+245.45%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.81%	689.69K	8.47M	-15.13K	-2.15%
Mar 31, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.95%	816.61K	10.03M	-1.68M	-67.23%
Mar 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.98%	834.85K	10.26M	110.43K	+15.24%
Mar 31, 2025	ALGERT GLOBAL LLC	1.03%	884.6K	10.87M	98.97K	+12.60%
Mar 31, 2025	PFM HEALTH SCIENCES, LP	1.08%	926.42K	11.38M	719.55K	+347.83%
Mar 31, 2025	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	1.43%	1.22M	15M	198.73K	+19.44%
Mar 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	2.12%	1.82M	22.32M	1.75M	+2,511.17%
Mar 31, 2025	WOODLINE PARTNERS LP	2.21%	1.89M	23.24M	0	0
Mar 31, 2025	KINGDON CAPITAL MANAGEMENT, L.L.C.	2.34%	2M	24.57M	0	0
Mar 31, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	1.53%	1.31M	16.08M	78.82K	+6.41%
Mar 31, 2025	EVENTIDE ASSET MANAGEMENT, LLC	1.38%	1.18M	14.47M	0	0
Mar 31, 2025	AISLING CAPITAL MANAGEMENT LP	1.2%	1.03M	12.59M	0	0
Mar 31, 2025	OCTAGON CAPITAL ADVISORS LP	1.06%	904K	11.11M	0	0
Mar 31, 2025	KYNAM CAPITAL MANAGEMENT, LP	9.95%	8.52M	104.67M	0	0
Mar 31, 2025	VANGUARD GROUP INC	5.69%	4.87M	59.84M	-10.9K	-0.22%
Mar 31, 2025	EVERSEPT PARTNERS, LP	4.92%	4.21M	51.75M	3.87M	+1,126.64%
Mar 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	4.68%	4.01M	49.25M	2.09M	+109.25%
Mar 31, 2025	STATE STREET CORP	4.64%	3.97M	48.79M	54.22K	+1.38%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	4.58%	3.92M	48.18M	-2.03M	-34.10%
Mar 31, 2025	PALO ALTO INVESTORS LP	0.52%	444.37K	5.46M	39.17K	+9.67%
Mar 31, 2025	MORGAN STANLEY	2.67%	2.28M	28.03M	-3.03M	-57.05%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.54%	465.88K	5.72M	134.58K	+40.62%
Mar 31, 2025	TWO SIGMA ADVISERS, LP	0.59%	503.15K	6.18M	-32.8K	-6.12%
Mar 31, 2025	SATURN V CAPITAL MANAGEMENT LLC	1.22%	1.04M	12.79M	52.75K	+5.34%
Mar 31, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.64%	544.5K	6.69M	2.5K	+0.46%
Mar 31, 2025	CANDRIAM S.C.A.	0.53%	450.44K	5.53M	-96.73K	-17.68%
Mar 31, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	0.65%	554.5K	6.81M	-6.03K	-1.08%
Mar 31, 2025	STEMPOINT CAPITAL LP	1.87%	1.6M	19.64M	-1.27M	-44.35%
Mar 31, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.51%	433K	5.32M	201K	+86.64%
Mar 31, 2025	SPHERA FUNDS MANAGEMENT LTD.	1.94%	1.66M	20.44M	282.73K	+20.47%
Mar 31, 2025		2.02%	1.73M	21.3M	1.73M	+100.00%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.36%	2.02M	24.86M	49.87K	+2.53%
Mar 31, 2025	ASSENAGON ASSET MANAGEMENT S.A.	2.38%	2.04M	25.06M	-24.47K	-1.19%
Mar 31, 2025	GRANAHAN INVESTMENT MANAGEMENT, LLC	0.64%	549.94K	6.76M	-355.38K	-39.25%
Mar 31, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.69%	594.99K	7.31M	68.01K	+12.91%
Mar 31, 2025	PROSIGHT MANAGEMENT, LP	0.71%	609.25K	7.48M	-10.75K	-1.73%
Mar 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.74%	631.64K	7.76M	9.8K	+1.58%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.8%	681.43K	8.37M	462	+0.07%
Mar 31, 2025	JPMORGAN CHASE & CO	1.29%	1.11M	13.58M	208.49K	+23.23%
Mar 31, 2024	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	1.08%	780K	18.56M	0	0
Mar 31, 2024	PARKMAN HEALTHCARE PARTNERS LLC	1.08%	784.81K	18.68M	46.22K	+6.26%
Mar 31, 2024	SCHONFELD STRATEGIC ADVISORS LLC	1.08%	785.64K	18.7M	314.17K	+66.64%
Mar 31, 2024	SPHERA FUNDS MANAGEMENT LTD.	1.12%	812.96K	19.35M	40K	+5.17%
Mar 31, 2024	FORESITE CAPITAL MANAGEMENT IV, LLC	1.21%	875K	20.83M	0	0
Mar 31, 2024	KINGDON CAPITAL MANAGEMENT, L.L.C.	1.23%	894.99K	21.3M	148.7K	+19.93%
Mar 31, 2024	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.24%	900K	21.42M	0	0
Mar 31, 2024	IRON TRIANGLE PARTNERS LP	1.34%	973.06K	23.16M	973.06K	+100.00%
Mar 31, 2024	AISLING CAPITAL MANAGEMENT LP	1.41%	1.03M	24.4M	0	0
Mar 31, 2024	CANDRIAM S.C.A.	1.44%	1.05M	24.87M	24K	+2.35%
Mar 31, 2024	STEMPOINT CAPITAL LP	1.52%	1.1M	26.2M	6.49K	+0.59%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	1.81%	1.31M	31.18M	59.13K	+4.73%
Mar 31, 2024	FRANKLIN RESOURCES INC	2.06%	1.5M	35.6M	142.8K	+10.56%
Mar 31, 2024	SOFINNOVA INVESTMENTS, INC.	2.22%	1.61M	38.28M	532.75K	+49.52%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	2.28%	1.66M	39.39M	670.79K	+68.15%
Mar 31, 2024	ORBIMED ADVISORS LLC	2.41%	1.75M	41.63M	0	0
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	2.45%	1.78M	42.34M	243.49K	+15.86%
Mar 31, 2024	MORGAN STANLEY	2.5%	1.82M	43.22M	151.45K	+9.10%
Mar 31, 2024	BVF INC/IL	2.59%	1.88M	44.63M	0	0
Mar 31, 2024	MARSHALL WACE, LLP	2.8%	2.03M	48.36M	-69.85K	-3.32%
Mar 31, 2024	POINT72 ASSET MANAGEMENT, L.P.	2.85%	2.07M	49.19M	-767.81K	-27.09%
Mar 31, 2024	AVIDITY PARTNERS MANAGEMENT LP	3.33%	2.41M	57.42M	-1.54M	-38.92%
Mar 31, 2024	EVERSEPT PARTNERS, LP	4.32%	3.13M	74.57M	-250.13K	-7.39%
Mar 31, 2024	VANGUARD GROUP INC	6.79%	4.93M	117.26M	591.63K	+13.65%
Mar 31, 2024	BLACKROCK INC.	10.41%	7.55M	179.75M	536.88K	+7.65%
Mar 31, 2024	FEDERATED HERMES, INC.	0.74%	538.71K	12.82M	538.71K	+100.00%
Mar 31, 2024	JPMORGAN CHASE & CO	0.94%	682.46K	16.24M	-98.47K	-12.61%
Mar 31, 2024	WOODLINE PARTNERS LP	2.13%	1.54M	36.75M	71	0.00%
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	0.51%	373.24K	8.88M	-30.14K	-7.47%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.54%	392.69K	9.35M	-231.32K	-37.07%
Mar 31, 2024	GRANAHAN INVESTMENT MANAGEMENT, LLC	0.55%	396.88K	9.45M	75.97K	+23.67%
Mar 31, 2024	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	3.39%	2.46M	58.53M	-252.02K	-9.30%
Mar 31, 2024	AVORO CAPITAL ADVISORS LLC	5.82%	4.22M	100.49M	0	0
Mar 31, 2024	STATE STREET CORP	6.65%	4.82M	114.71M	-196.63K	-3.92%
Mar 31, 2024	PROFUND ADVISORS LLC	0.08%	58.25K	1.39B	-6.94K	-10.64%
Mar 31, 2024	ALPS ADVISORS INC	0.08%	59.92K	1.43M	11.8K	+24.51%
Mar 31, 2024	KNOTT DAVID M JR	0.09%	65.48K	1.56M	65.48K	+100.00%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.1%	69.78K	1.66B	14.66K	+26.59%
Mar 31, 2024	TREXQUANT INVESTMENT LP	0.1%	74.59K	1.78M	-68.92K	-48.02%
Mar 31, 2024	SIMPLIFY ASSET MANAGEMENT INC.	0.1%	75.34K	1.79M	63.54K	+538.40%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.11%	77.46K	1.84M	0	0
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.11%	79.1K	1.88M	79.1K	+100.00%
Mar 31, 2024	PROPEL BIO MANAGEMENT, LLC	0.11%	83.26K	1.98M	83.26K	+100.00%
Mar 31, 2024	CREDIT SUISSE AG/	0.12%	86.22K	2.05M	13.45K	+18.48%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.13%	93.89K	2.23M	36.53K	+63.68%
Mar 31, 2024	AXIOM INVESTORS LLC /DE	0.13%	94.07K	2.24M	7.89K	+9.16%
Mar 31, 2024	CRESTLINE MANAGEMENT, LP	0.14%	103.71K	2.47M	3.06K	+3.04%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	0.15%	108.65K	2.59M	-658	-0.60%
Mar 31, 2024	RHUMBLINE ADVISERS	0.15%	108.99K	2.59M	13.68K	+14.35%
Mar 31, 2024	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.15%	109.83K	2.61M	109.83K	+100.00%
Mar 31, 2024	STATE OF NEW JERSEY COMMON PENSION FUND D	0.16%	114.38K	2.72M	-45.42K	-28.42%
Mar 31, 2024	YELIN LAPIDOT HOLDINGS MANAGEMENT LTD.	0.16%	114.53K	2.73M	0	0
Mar 31, 2024	SWISS NATIONAL BANK	0.21%	150.6K	3.58M	8.2K	+5.76%
Mar 31, 2024	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.25%	178.5K	4.25M	178.5K	+100.00%
Mar 31, 2024	PEREGRINE CAPITAL MANAGEMENT LLC	0.27%	196.08K	4.67M	46	+0.02%
Mar 31, 2024	PANAGORA ASSET MANAGEMENT INC	0.33%	237.01K	5.64M	62.86K	+36.10%
Mar 31, 2024	MACQUARIE GROUP LTD	0.34%	242.99K	5.78M	-1.1K	-0.45%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.34%	245.36K	5.84M	14.51K	+6.28%
Mar 31, 2024	UBS GROUP AG	0.37%	269.81K	6.42M	-20.99K	-7.22%
Mar 31, 2024	ASSENAGON ASSET MANAGEMENT S.A.	0.38%	277.93K	6.61M	-134.04K	-32.54%
Mar 31, 2024	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.39%	286.33K	6.82M	-66.92K	-18.94%
Mar 31, 2024	CITIGROUP INC	0.45%	324.93K	7.73M	162.52K	+100.07%
Mar 31, 2024	VERITION FUND MANAGEMENT LLC	0.48%	346.86K	8.26M	203.6K	+142.11%
Mar 31, 2024	SATURN V CAPITAL MANAGEMENT LLC	0.55%	398K	9.47M	-120.8K	-23.28%
Mar 31, 2024	PALO ALTO INVESTORS LP	0.56%	405.19K	9.64M	-67.41K	-14.26%
Mar 31, 2024	ALGERT GLOBAL LLC	0.59%	425.67K	10.13M	-102.48K	-19.40%
Mar 31, 2024	TWO SIGMA ADVISERS, LP	0.63%	455.85K	10.85M	304.4K	+200.99%
Mar 31, 2024	NANTAHALA CAPITAL MANAGEMENT, LLC	0.64%	465.26K	11.07M	100K	+27.38%
Mar 31, 2024	AMERIPRISE FINANCIAL INC	0.71%	511.5K	12.17M	5.49K	+1.09%
Mar 31, 2024	ENSIGN PEAK ADVISORS, INC	0.71%	514.85K	12.25M	0	0
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.88%	635.21K	15.12M	58.19K	+10.08%
Mar 31, 2024	PFM HEALTH SCIENCES, LP	0.91%	658.69K	15.68M	63.17K	+10.61%
Mar 31, 2024	DAFNA CAPITAL MANAGEMENT LLC	0.91%	659.57K	15.7M	-83K	-11.18%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	0.94%	681.87K	16.23M	-260.77K	-27.66%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.99%	718.55K	17.1M	182.61K	+34.07%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	1.02%	736.15K	17.52M	711.75K	+2,917.37%
Mar 31, 2024	NORTHERN TRUST CORP	1.02%	741.83K	17.66M	63.72K	+9.40%
Mar 31, 2024	KYNAM CAPITAL MANAGEMENT, LP	7.8%	5.66M	134.71M	0	0
Mar 31, 2024	WELLINGTON MANAGEMENT GROUP LLP	10.25%	7.44M	176.99M	-148.61K	-1.96%
Dec 31, 2023	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	1.12%	780K	16.86M	780K	+100.00%
Dec 31, 2023	SPHERA FUNDS MANAGEMENT LTD.	1.11%	772.96K	16.7M	-97	-0.01%
Dec 31, 2023	KINGDON CAPITAL MANAGEMENT, L.L.C.	1.07%	746.29K	16.13M	746.29K	+100.00%
Dec 31, 2023	DAFNA CAPITAL MANAGEMENT LLC	1.06%	742.57K	16.05M	284.2K	+62.00%
Dec 31, 2023	PARKMAN HEALTHCARE PARTNERS LLC	1.06%	738.59K	15.96M	526.14K	+247.66%
Dec 31, 2023	NORTHERN TRUST CORP	0.97%	678.11K	14.65M	42.58K	+6.70%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.89%	624.01K	13.48M	450.57K	+259.79%
Dec 31, 2023	PFM HEALTH SCIENCES, LP	0.85%	595.52K	12.87M	-2.12M	-78.07%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.83%	577.02K	12.47M	70.56K	+13.93%
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	0.77%	535.94K	11.58M	104.37K	+24.18%
Dec 31, 2023	ALGERT GLOBAL LLC	0.76%	528.16K	11.41M	71.94K	+15.77%
Dec 31, 2023	STATE STREET CORP	7.18%	5.02M	108.4M	1.42M	+39.31%
Dec 31, 2023	KYNAM CAPITAL MANAGEMENT, LP	8.1%	5.66M	122.31M	2.06M	+57.22%
Dec 31, 2023	SATURN V CAPITAL MANAGEMENT LLC	0.74%	518.8K	11.21M	-289.17K	-35.79%
Dec 31, 2023	FORESITE CAPITAL MANAGEMENT IV, LLC	1.25%	875K	18.91M	0	0
Dec 31, 2023	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.29%	900K	19.45M	-100K	-10.00%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	1.35%	942.64K	20.37M	502.87K	+114.35%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	1.41%	984.26K	21.27M	724.4K	+278.77%
Dec 31, 2023	ENSIGN PEAK ADVISORS, INC	0.74%	514.85K	11.13M	0	0
Dec 31, 2023	CANDRIAM S.C.A.	1.46%	1.02M	22.07M	781.02K	+325.41%
Dec 31, 2023	AISLING CAPITAL MANAGEMENT LP	1.47%	1.03M	22.15M	0	0
Dec 31, 2023	SOFINNOVA INVESTMENTS, INC.	1.54%	1.08M	23.25M	133.97K	+14.22%
Dec 31, 2023		1.57%	1.09M	23.65M	1.09M	+100.00%
Dec 31, 2023	CORMORANT ASSET MANAGEMENT, LP	1.68%	1.18M	25.39M	1.18M	+100.00%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	1.79%	1.25M	27.03M	-16.8K	-1.33%
Dec 31, 2023	SOLEUS CAPITAL MANAGEMENT, L.P.	0.74%	514K	11.11M	394.5K	+330.13%
Dec 31, 2023	FRANKLIN RESOURCES INC	1.94%	1.35M	29.24M	1.35M	+100.00%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	2.2%	1.54M	33.18M	174.14K	+12.80%
Dec 31, 2023	WOODLINE PARTNERS LP	2.21%	1.54M	33.37M	1.51M	+4,432.88%
Dec 31, 2023	MORGAN STANLEY	2.38%	1.66M	35.97M	1.11M	+202.59%
Dec 31, 2023	ORBIMED ADVISORS LLC	2.5%	1.75M	37.8M	465K	+36.22%
Dec 31, 2023	BVF INC/IL	2.68%	1.88M	40.52M	1.88M	+100.00%
Dec 31, 2023	MARSHALL WACE, LLP	3.01%	2.1M	45.42M	1.5M	+248.02%
Dec 31, 2023	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	3.88%	2.71M	58.59M	1.64M	+154.21%
Dec 31, 2023	POINT72 ASSET MANAGEMENT, L.P.	4.06%	2.83M	61.25M	740.3K	+35.35%
Dec 31, 2023	AMERIPRISE FINANCIAL INC	0.72%	506.01K	10.93M	6.49K	+1.30%
Dec 31, 2023	PALO ALTO INVESTORS LP	0.68%	472.6K	10.21M	0	0
Dec 31, 2023	SCHONFELD STRATEGIC ADVISORS LLC	0.67%	471.48K	10.19M	253.06K	+115.86%
Dec 31, 2023	ASSENAGON ASSET MANAGEMENT S.A.	0.59%	411.97K	8.9M	21.43K	+5.49%
Dec 31, 2023	RAFFERTY ASSET MANAGEMENT, LLC	0.58%	403.38K	8.72M	119.26K	+41.97%
Dec 31, 2023	NANTAHALA CAPITAL MANAGEMENT, LLC	0.52%	365.26K	7.89M	125.23K	+52.17%
Dec 31, 2023	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.51%	353.25K	7.63M	197.54K	+126.86%
Dec 31, 2023	GRANAHAN INVESTMENT MANAGEMENT, LLC	0.46%	320.91K	6.93M	320.91K	+100.00%
Dec 31, 2023	WELLINGTON MANAGEMENT GROUP LLP	10.86%	7.59M	163.92M	7.59M	+100.00%
Dec 31, 2023	EVERSEPT PARTNERS, LP	4.84%	3.38M	73.11M	787K	+30.31%
Dec 31, 2023	AVIDITY PARTNERS MANAGEMENT LP	5.65%	3.95M	85.36M	1.13M	+40.02%
Dec 31, 2023	AVORO CAPITAL ADVISORS LLC	6.04%	4.22M	91.24M	1.67M	+65.22%
Dec 31, 2023	VANGUARD GROUP INC	6.21%	4.34M	93.69M	718.05K	+19.85%
Dec 31, 2023	BLACKROCK INC.	10.04%	7.02M	151.61M	1.13M	+19.26%
Dec 31, 2023	JPMORGAN CHASE & CO	1.12%	780.93K	16.88M	51.83K	+7.11%

Insiders

Among the SNDX insiders holding of 1.28% of the stake in company, ROYSTON IVOR, director, holds the largest shares of 750.55K. METZGER MICHAEL A, Chief Executive Officer, is the second largest SNDX insider with ownership of 491.69K shares. PODLESAK DENNIS, director, stands third with possession of 191.76K shares of that stake.

Insiders	Designation	Shares Held
ROYSTON IVOR	director	750.55K
METZGER MICHAEL A	Chief Executive Officer	491.69K
PODLESAK DENNIS	director	191.76K
GOLDAN KEITH A.	Chief Financial Officer	140.43K
KATKIN KEITH	director	100K
GALLAGHER NEIL	President, Head of R&D	85.1K
HUBER MARTIN H. JR.	director	79K
MEURY WILLIAM	director	48K
BOTWOOD NICHOLAS A.J.	Head of R&D, CMO	35.17K
LEGAULT PIERRE	director	32K
MORRISON BRIGGS	director	17.84K
EGROS FABRICE		16K
MEYERS MICHAEL L.	SVP, Chief Medical Officer	15.67K
NOLTE ALEXANDER		0
ORDENTLICH PETER		0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Feb 09, 2026	METZGER MICHAEL A	SALE	21.03	17.16K	360.82K	491.69K
Feb 09, 2026	GOLDAN KEITH A.	SALE	21.03	3.41K	71.71K	140.43K
Feb 06, 2026	GOLDAN KEITH A.	SALE	20.62	2.08K	42.93K	143.84K
Feb 06, 2026	METZGER MICHAEL A	SALE	20.62	7.41K	152.84K	508.85K
Sep 08, 2025	METZGER MICHAEL A	SALE	16.41	157.31K	2.58M	298.66K
Aug 18, 2025	PODLESAK DENNIS	SALE	15.84	19.2K	304.17K	191.76K
Aug 15, 2025	PODLESAK DENNIS	SALE	15.54	19.2K	298.41K	191.76K
Aug 14, 2025	PODLESAK DENNIS	SALE	14.19	19.2K	272.52K	191.76K
Jul 16, 2025	METZGER MICHAEL A	SALE	9.29	7.53K	69.95K	298.66K
Jul 16, 2025	GOLDAN KEITH A.	SALE	9.29	1.3K	12.03K	92.45K
May 19, 2025	KATKIN KEITH	PURCHASE	9.11	10K	91.12K	100K
May 19, 2025	GOLDAN KEITH A.	PURCHASE	0.00	3K	-	93.75K
May 19, 2025	HUBER MARTIN H. JR.	PURCHASE	8.99	5K	44.95K	79K
May 16, 2025	BOTWOOD NICHOLAS A.J.	PURCHASE	8.99	11.77K	105.83K	35.17K
Mar 04, 2025	METZGER MICHAEL A	SALE	15.05	7.81K	117.56K	300.12K
Feb 10, 2025	GALLAGHER NEIL	SALE	15.50	4.62K	71.6K	85.1K
Feb 10, 2025	GOLDAN KEITH A.	SALE	15.50	3.78K	58.56K	90.75K
Feb 10, 2025	METZGER MICHAEL A	SALE	15.50	13.29K	206.02K	300.12K
Jun 14, 2024	GOLDAN KEITH A.	PURCHASE	20.03	1.25K	25.04K	52.62K
Aug 09, 2023	MORRISON BRIGGS	SALE	18.27	52.86K	965.4K	17.84K
Aug 02, 2023	MEURY WILLIAM	SALE	20.45	24K	490.91K	48K
Jul 10, 2023	MORRISON BRIGGS	SALE	20.40	52.86K	1.08M	17.84K
Jun 13, 2023	GOLDAN KEITH A.	SALE	22.31	577	12.87K	2.63K
Jun 09, 2023	MORRISON BRIGGS	SALE	21.18	28.27K	598.8K	17.84K
May 09, 2023	MORRISON BRIGGS	SALE	21.41	52.86K	1.13M	17.84K
Apr 10, 2023	MORRISON BRIGGS	SALE	19.53	52.86K	1.03M	17.84K
Mar 13, 2023	MORRISON BRIGGS	SALE	22.53	52.85K	1.19M	17.84K
Feb 15, 2023	ORDENTLICH PETER	SALE	25.84	17.43K	450.4K	0
Feb 06, 2023	MORRISON BRIGGS	SALE	26.83	52.85K	1.42M	17.84K
Feb 06, 2023	METZGER MICHAEL A	SALE	27.64	5.96K	164.7K	17.66K
Feb 01, 2023	ORDENTLICH PETER	SALE	28.43	69	1.96K	0
Jan 13, 2023	LEGAULT PIERRE	SALE	27.00	5K	135K	32K
Dec 02, 2022	ORDENTLICH PETER	SALE	25.05	17.2K	430.94K	265
Oct 06, 2022	METZGER MICHAEL A	SALE	25.29	16.23K	410.51K	17.66K
Oct 06, 2022	KATKIN KEITH	SALE	25.90	20.78K	538.27K	32K
Oct 04, 2022	METZGER MICHAEL A	SALE	25.02	1.28K	32.03K	17.66K
Oct 04, 2022	KATKIN KEITH	SALE	25.00	137	3.43K	32K
Sep 20, 2022	MORRISON BRIGGS	SALE	23.25	59.65K	1.39M	17.84K
Sep 19, 2022	MORRISON BRIGGS	SALE	23.03	114.34K	2.63M	17.84K
Sep 16, 2022	PODLESAK DENNIS	SALE	23.43	6.56K	153.62K	75.76K
Sep 16, 2022	MORRISON BRIGGS	SALE	23.22	53.03K	1.23M	17.84K
Sep 15, 2022	PODLESAK DENNIS	SALE	24.20	66.84K	1.62M	75.76K
Sep 15, 2022	MORRISON BRIGGS	SALE	24.20	66.78K	1.62M	17.84K
Sep 14, 2022	MORRISON BRIGGS	SALE	23.80	87.65K	2.09M	17.84K
Aug 05, 2022	LEGAULT PIERRE	SALE	23.02	14K	322.22K	32K
Jul 29, 2022	ORDENTLICH PETER	SALE	25.04	2.15K	53.93K	265
Jul 25, 2022	METZGER MICHAEL A	SALE	21.06	19.76K	416.14K	17.66K
Jul 06, 2022	METZGER MICHAEL A	SALE	21.00	100	2.1K	17.66K
Jul 01, 2022	MORRISON BRIGGS	SALE	19.00	62.29K	1.18M	17.84K
Apr 04, 2022	MORRISON BRIGGS	SALE	18.29	3.13K	57.22K	17.84K
Apr 01, 2022	MORRISON BRIGGS	SALE	17.46	70.55K	1.23M	17.84K
Feb 01, 2022	ORDENTLICH PETER	SALE	16.65	1.41K	23.51K	0
Feb 01, 2022	NOLTE ALEXANDER	SALE	16.65	968	16.12K	0
Dec 22, 2021	LEGAULT PIERRE	SALE	22.01	24K	528.21K	16K
Dec 20, 2021	LEGAULT PIERRE	SALE	21.01	20K	420.25K	16K
Dec 20, 2021	METZGER MICHAEL A	SALE	20.29	45K	912.96K	17.66K
Dec 17, 2021	MORRISON BRIGGS	SALE	20.00	35.16K	703.12K	48.34K
Dec 17, 2021	METZGER MICHAEL A	SALE	19.02	1.68K	31.88K	17.66K
Dec 16, 2021	METZGER MICHAEL A	SALE	19.08	22.72K	433.4K	17.66K
Dec 13, 2021	METZGER MICHAEL A	SALE	19.05	34.56K	658.55K	17.66K
Nov 18, 2021	EGROS FABRICE	SALE	18.03	30	540.97	16K
Oct 26, 2021	METZGER MICHAEL A	SALE	19.20	16.3K	312.82K	17.66K
Oct 25, 2021	METZGER MICHAEL A	SALE	19.13	44.7K	855.34K	17.66K
Sep 27, 2021	METZGER MICHAEL A	SALE	19.51	24.44K	476.83K	17.66K
Sep 22, 2021	METZGER MICHAEL A	SALE	19.02	300	5.71K	17.66K
Sep 21, 2021	METZGER MICHAEL A	SALE	19.16	4.81K	92.11K	17.66K
Sep 20, 2021	MORRISON BRIGGS	SALE	20.00	50	1K	48.34K
Sep 20, 2021	METZGER MICHAEL A	SALE	19.24	31.46K	605.05K	17.66K
Sep 17, 2021	MORRISON BRIGGS	SALE	20.07	70.26K	1.41M	48.34K
Sep 14, 2021	METZGER MICHAEL A	SALE	19.15	44.35K	849.39K	17.66K
Sep 13, 2021	METZGER MICHAEL A	SALE	19.02	16.65K	316.64K	17.66K
Aug 18, 2021	EGROS FABRICE	SALE	15.75	15.64K	246.33K	16K
May 18, 2021	EGROS FABRICE	SALE	18.65	1.68K	31.38K	16K
Apr 26, 2021	MEYERS MICHAEL L.	PURCHASE	15.46	500	7.73K	15.67K
Apr 22, 2021	PODLESAK DENNIS	PURCHASE	14.11	13.97K	197.08K	43.3K
Mar 01, 2021	EGROS FABRICE	SALE	24.31	74	1.8K	16K
Feb 08, 2021	MORRISON BRIGGS	SALE	20.55	35.16K	722.4K	48.34K
Feb 01, 2021	METZGER MICHAEL A	SALE	20.19	15K	302.8K	17.66K
Dec 01, 2020	METZGER MICHAEL A	SALE	22.97	15K	344.51K	17.66K
Nov 23, 2020	ORDENTLICH PETER	SALE	22.89	16.33K	373.92K	0
Nov 10, 2020	MORRISON BRIGGS	SALE	20.06	17.47K	350.31K	46.57K
Nov 09, 2020	MORRISON BRIGGS	SALE	20.04	62.94K	1.26M	46.57K
Nov 04, 2020	METZGER MICHAEL A	SALE	20.31	100K	2.03M	17.66K
Feb 04, 2020	MORRISON BRIGGS	PURCHASE	8.00	12.5K	100K	43.9K
Oct 10, 2019	MORRISON BRIGGS	PURCHASE	5.40	11K	59.4K	31.4K
May 13, 2019	MORRISON BRIGGS	PURCHASE	7.29	7.2K	52.52K	20.4K
May 09, 2019	MORRISON BRIGGS	PURCHASE	7.55	13.2K	99.73K	13.2K
Mar 21, 2019	MEYERS MICHAEL L.	PURCHASE	4.93	1K	4.93K	7.12K
Oct 30, 2018	MEYERS MICHAEL L.	PURCHASE	4.79	200	958	2.4K
Apr 03, 2018	ORDENTLICH PETER	SALE	15.00	7.5K	112.5K	0
May 17, 2017	ORDENTLICH PETER	SALE	15.00	5K	75K	0
Mar 08, 2016	ROYSTON IVOR	PURCHASE	12.00	150K	1.8M	750.55K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES187.37K5

NET SHARES-187.37K5

SHARES HELD1.58M5

% NET SHARES-111.83%0%

Frequently Asked Questions