How many institutions own RYTM stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own RYTM shares is 333, representing 105.05% of the company's common stock.

Who are the major shareholders selling Rhythm Pharmaceuticals, Inc. stock?

PANAGORA ASSET MANAGEMENT INC, in the last quarter, reduced its stake in RYTM by -45.91% restricting it's holding to 64.61 thousand shares of worth nearly $6.53M. RHUMBLINE ADVISERS also lessened -6.24% of the RYTM shares from its portfolio, reducing its holding to 82.07 thousand shares of worth $8.29M. CHECKPOINT CAPITAL L.P. also shunned RYTM shares holding by -27.95% last quarter which brought its holding to 763.71 thousand shares worth $77.13M.

Investors who are buying RYTM stock?

As per its latest 13F filing, CAPITAL RESEARCH GLOBAL INVESTORS increased its stake in RYTM by 100% in the last quarter. The institutional holder raised its holding to 598.25 thousand shares having worth more than $60.42M. RAFFERTY ASSET MANAGEMENT, LLC also added 7.99% more shares of RYTM to its portfolio, raising its holding to 55.73 thousand shares of worth $5.63M. LEGAL & GENERAL GROUP PLC also increased its RYTM shares holding by 8.91% which brought its holding to 57.38 thousand shares worth $5.79M.

RYTM's major insiders: who are they?

The insider with the most stakes in RYTM is RA CAPITAL MANAGEMENT, L.P. , at the company. Additionally, RYTM stock is highly held by director Foley Todd and President and CEO Meeker David P among others.

Did an insider recently sell RYTM stock?

Company executives, directors, and other insiders own 0.65% percent of Rhythm Pharmaceuticals, Inc.'s stock. Within the last six months, there have been 19 transaction(s) in which RYTM insiders have sold stock, totaling 134.36K shares. Insiders that have sold shares include CRAMER PAMELA J., SHULMAN JOSEPH, and SMITH HUNTER C.

Which insider recently purchased RYTM stock?

There have been 0 transaction(s) during the past 6-months in which Rhythm Pharmaceuticals, Inc. insiders have bought stock, totalling 0 shares

How much of RYTM does insiders own?

Around 538.56K Rhythm Pharmaceuticals, Inc. shares are held by insiders, which represents about 0.65% of RYTM stock.

Who is the insider with the largest stake?

RYTM , RA CAPITAL MANAGEMENT, L.P. holds the largest portfolio of the company's shares. RYTM shares owned by RA total nearly 4.36 million.

Which institution holds the most shares in RYTM?

CAPITAL RESEARCH GLOBAL INVESTORS is the largest institutional owner in RYTM which holds 598.25 thousand shares worth $60.42M or 0.94% of the total RYTM shares outstanding followed by NAN FUNG GROUP HOLDINGS LTD with ownership of 49.12 thousand shares representing 0.08% of the RYTM ownership. RAFFERTY ASSET MANAGEMENT, LLC is the third largest stakeholder with 55.73 thousand shares or 0.09% of the ownership worth more than $5.63M.

Is Rhythm Pharmaceuticals, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the RYTM is concerned, it is a stock which is optionable.

Is there a short position on RYTM's shares?

Number of RYTM shares short is 4.67M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding RYTM shares are there?

As of today, 66.42M shares of RYTM are outstanding.

Is there many float in RYTM stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, RYTM has 54.80M shares in float.

RYTM short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for RYTM is 7.76.

Rhythm Pharmaceuticals (RYTM) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares7.04

Short Percent Of Float9.03

Shares Outstanding66.42M

Shares Float54.80M

Shares Short4.67M

Short Ratio7.76

9.03%

Short % of Float

7.04%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

0.65% Percentage of Shares held by All Insiders

105.05% Percentage of Shares held by All Institutions

105.73% Percentage of Float held by Institutions

333

Number of Institutions Holding Shares

Institutional Ownership

About 105.05% of RYTM shares are held by financial institutions. CAPITAL RESEARCH GLOBAL INVESTORS is the top corporate investor, holding 598.25K shares valued at $60.42M. A 0.94% stake in Rhythm Pharmaceuticals, Inc. is owned by the company. NAN FUNG GROUP HOLDINGS LTD owns 49.12K shares valued at $4.96M, which translates its holding of 0.08% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	CAPITAL RESEARCH GLOBAL INVESTORS	0.94%	598.25K	60.42M	598.25K	+100.00%
Sep 30, 2025	NAN FUNG GROUP HOLDINGS LTD	0.08%	49.12K	4.96M	0	0
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.09%	55.73K	5.63M	4.12K	+7.99%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.09%	57.38K	5.79M	4.7K	+8.91%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.09%	59.56K	6.02M	3.56K	+6.36%
Sep 30, 2025	PANAGORA ASSET MANAGEMENT INC	0.1%	64.61K	6.53M	-54.85K	-45.91%
Sep 30, 2025	PRUDENTIAL FINANCIAL INC	0.11%	73.01K	7.37M	65.92K	+929.03%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.12%	75.13K	7.59M	16.51K	+28.17%
Sep 30, 2025	FIRST TRUST ADVISORS LP	0.13%	80.9K	8.17M	7.19K	+9.75%
Sep 30, 2025	RHUMBLINE ADVISERS	0.13%	82.07K	8.29M	-5.46K	-6.24%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.2%	1.4M	141.38M	58.51K	+4.36%
Sep 30, 2025	ALKEON CAPITAL MANAGEMENT LLC	1.6%	1.02M	102.78M	0	0
Sep 30, 2025	CHECKPOINT CAPITAL L.P.	1.2%	763.71K	77.13M	-296.29K	-27.95%
Sep 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	1.13%	717.1K	72.42M	-144.05K	-16.73%
Sep 30, 2025	WOODLINE PARTNERS LP	0.91%	580.18K	58.59M	65.8K	+12.79%
Sep 30, 2025	FRANKLIN RESOURCES INC	0.89%	567.78K	57.34M	23.98K	+4.41%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.83%	527.92K	53.31M	66.48K	+14.41%
Sep 30, 2025	LOOMIS SAYLES & CO L P	0.83%	527.44K	53.27M	-64.02K	-10.82%
Sep 30, 2025	HOOD RIVER CAPITAL MANAGEMENT LLC	0.37%	235.84K	23.82M	-307.85K	-56.62%
Sep 30, 2025	NEUBERGER BERMAN GROUP LLC	0.13%	85.12K	8.6M	-1.02K	-1.19%
Sep 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.16%	101.37K	10.24M	5.86K	+6.13%
Sep 30, 2025	SWISS NATIONAL BANK	0.16%	102.3K	10.33M	11.7K	+12.91%
Sep 30, 2025	ENSIGN PEAK ADVISORS, INC	0.18%	111.54K	11.26M	93.89K	+531.66%
Sep 30, 2025	DEUTSCHE BANK AG\	0.18%	116.74K	11.79M	79.96K	+217.41%
Sep 30, 2025	NUVEEN, LLC	0.19%	117.96K	11.91M	-3.89K	-3.19%
Sep 30, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.19%	121.26K	12.25B	6.14K	+5.34%
Sep 30, 2025	BARCLAYS PLC	0.22%	142.39K	14.38M	-208.81K	-59.46%
Sep 30, 2025	INVESCO LTD.	0.23%	143.56K	14.5M	74.63K	+108.28%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.25%	157.68K	15.92M	26.68K	+20.37%
Sep 30, 2025	MARSHALL WACE, LLP	0.27%	171.83K	17.35M	-204.41K	-54.33%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.29%	182.37K	18.42M	-1.74K	-0.95%
Sep 30, 2025	MORGAN STANLEY	0.73%	465.19K	46.98M	-59.29K	-11.30%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.35%	223.68K	22.59M	121.44K	+118.78%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.55%	350.01K	35.35M	295.92K	+547.11%
Sep 30, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.58%	370K	37.37M	-30.78K	-7.68%
Sep 30, 2025	JENNISON ASSOCIATES LLC	0.65%	411.55K	41.56M	411.55K	+100.00%
Sep 30, 2025	CLEARBRIDGE INVESTMENTS, LLC	0.76%	484.73K	48.95M	172.29K	+55.14%
Sep 30, 2025	WCM INVESTMENT MANAGEMENT, LLC	0.08%	47.73K	4.8M	47.73K	+100.00%
Sep 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.07%	683.02K	68.95M	266.9K	+64.14%
Sep 30, 2025	WESTFIELD CAPITAL MANAGEMENT CO LP	1.68%	1.07M	107.96M	-560.46K	-34.40%
Sep 30, 2025	FEDERATED HERMES, INC.	2.71%	1.73M	174.5M	41.39K	+2.45%
Sep 30, 2025	FMR LLC	3.37%	2.15M	216.64M	191.74K	+9.82%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.37%	233.15K	23.55M	11K	+4.95%
Sep 30, 2025	ARTISAN PARTNERS LIMITED PARTNERSHIP	0.37%	236.84K	23.92M	62.36K	+35.74%
Sep 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.38%	238.82K	24.12M	-1.53K	-0.63%
Sep 30, 2025	SOFINNOVA INVESTMENTS, INC.	0.39%	246.97K	24.94M	-339.04K	-57.86%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.41%	259.6K	26.22M	199.4K	+331.23%
Sep 30, 2025	UBS GROUP AG	0.66%	420.34K	42.45M	167.75K	+66.42%
Sep 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.69%	437.47K	44.18M	209.85K	+92.19%
Sep 30, 2025	OPALEYE MANAGEMENT INC.	0.72%	461.7K	46.63M	-13.3K	-2.80%
Sep 30, 2025	SIREN, L.L.C.	0.79%	499.98K	50.49M	90.23K	+22.02%
Sep 30, 2025	NORTHERN TRUST CORP	0.8%	510.91K	51.6M	660	+0.13%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.85%	544K	54.94M	203K	+59.53%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.86%	546.59K	55.2M	231.7K	+73.58%
Sep 30, 2025	ALLIANCEBERNSTEIN L.P.	1.54%	979.68K	98.94M	918.21K	+1,493.76%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	2.97%	1.89M	191.24M	159.94K	+9.23%
Sep 30, 2025	STATE STREET CORP	3.19%	2.03M	204.87M	121.05K	+6.35%
Sep 30, 2025	NEA MANAGEMENT COMPANY, LLC	4.57%	2.91M	293.88M	0	0
Sep 30, 2025	PRIMECAP MANAGEMENT CO/CA/	6.69%	4.26M	430.51M	-615.18K	-12.61%
Sep 30, 2025	VANGUARD GROUP INC	7.85%	5M	504.59M	1.41M	+39.21%
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	8.92%	5.68M	573.76M	120K	+2.16%
Sep 30, 2025	BLACKROCK, INC.	9.9%	6.3M	636.46M	34.68K	+0.55%
Sep 30, 2025	BAKER BROS. ADVISORS LP	8.8%	5.6M	566M	0	0
Sep 30, 2025	COMERICA BANK	0.33%	209.33K	21.14M	-92.34K	-30.61%
Sep 30, 2025	ORBIMED ADVISORS LLC	0.34%	215.15K	21.73M	-33.36K	-13.42%
Sep 30, 2025	INTEGRAL HEALTH ASSET MANAGEMENT, LLC	0.35%	220K	22.22M	100K	+83.33%
Sep 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.35%	221.59K	22.38M	-22.41K	-9.18%
Sep 30, 2025	PERCEPTIVE ADVISORS LLC	658.1%	419.1M	288.39M	416.69M	+17,230.57%
Sep 30, 2025	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.58%	368.26K	37.19M	29.46K	+8.70%
Sep 30, 2025	LORD, ABBETT & CO. LLC	0.9%	575.98K	58.17M	371.71K	+181.97%
Sep 30, 2025	CANDRIAM S.C.A.	0.35%	221.86K	22.41M	-90.59K	-28.99%
Sep 30, 2025	JANUS HENDERSON GROUP PLC	1.82%	1.16M	117.24M	-251.02K	-17.78%
Sep 30, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.35%	224.13K	22.63M	-13.87K	-5.83%
Sep 30, 2025	JPMORGAN CHASE & CO	1.87%	1.19M	119.98M	404.51K	+51.62%
Sep 30, 2025	POLAR CAPITAL HOLDINGS PLC	1.95%	1.24M	125.73M	-5.94K	-0.47%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.14%	1.36M	137.65M	51.58K	+3.93%
Sep 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	2.17%	1.38M	139.75M	113.82K	+8.96%
Sep 30, 2025	HILLSDALE INVESTMENT MANAGEMENT INC.	0.07%	42.6K	4.3M	42.6K	+100.00%
Sep 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.07%	42.88K	4.33M	26.64K	+164.04%
Sep 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.07%	44.73K	4.52M	-6.35K	-12.43%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.07%	47.13K	4.76M	4.77K	+11.25%
Jun 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.38%	240.35K	15.19M	24.15K	+11.17%
Jun 30, 2025	BARCLAYS PLC	0.55%	351.2K	22.19M	249.98K	+246.98%
Jun 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	1.99%	1.27M	80.25M	-188.07K	-12.90%
Jun 30, 2025	MARSHALL WACE, LLP	0.59%	376.24K	23.77M	-158.86K	-29.69%
Jun 30, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.63%	400.77K	25.32M	63.17K	+18.71%
Jun 30, 2025	SIREN, L.L.C.	0.64%	409.74K	25.89M	132.21K	+47.64%
Jun 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.65%	416.12K	26.26M	156.77K	+60.45%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.72%	461.44K	29.16M	16.01K	+3.59%
Jun 30, 2025	WOODLINE PARTNERS LP	0.81%	514.38K	32.5M	514.38K	+100.00%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.31%	198.11K	12.52M	-19.27K	-8.86%
Jun 30, 2025	LORD, ABBETT & CO. LLC	0.32%	204.28K	12.91M	68.92K	+50.91%
Jun 30, 2025	NORGES BANK	0.33%	207.39K	13.1M	207.39K	+100.00%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.35%	222.15K	14.04M	110.4K	+98.79%
Jun 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.36%	227.63K	14.38M	101.85K	+80.97%
Jun 30, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.37%	238K	15.04M	215.81K	+972.45%
Jun 30, 2025	HOOD RIVER CAPITAL MANAGEMENT LLC	0.85%	543.69K	34.36M	-115.74K	-17.55%
Jun 30, 2025	LOOMIS SAYLES & CO L P	0.93%	591.45K	37.37M	-14.31K	-2.36%
Jun 30, 2025	PERCEPTIVE ADVISORS LLC	3.8%	2.42M	152.81M	-130.15K	-5.11%
Jun 30, 2025	NEA MANAGEMENT COMPANY, LLC	4.57%	2.91M	183.88M	0	0
Jun 30, 2025	PRIMECAP MANAGEMENT CO/CA/	7.66%	4.88M	308.24M	-909.29K	-15.71%
Jun 30, 2025	NORTHERN TRUST CORP	0.8%	510.25K	32.24M	-25.96K	-4.84%
Jun 30, 2025	FRANKLIN RESOURCES INC	0.85%	543.8K	34.36M	217.64K	+66.73%
Jun 30, 2025	SOFINNOVA INVESTMENTS, INC.	0.35%	225K	14.22M	225K	+100.00%
Jun 30, 2025	ALKEON CAPITAL MANAGEMENT LLC	1.6%	1.02M	64.31M	200K	+24.46%
Jun 30, 2025	CHECKPOINT CAPITAL L.P.	1.66%	1.06M	66.98M	152.76K	+16.84%
Jun 30, 2025	WESTFIELD CAPITAL MANAGEMENT CO LP	2.56%	1.63M	102.97M	288.38K	+21.50%
Jun 30, 2025	BAKER BROS. ADVISORS LP	8.8%	5.6M	354.15M	0	0
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.1%	61.47K	3.88B	0	0
Jun 30, 2025	HARBOR CAPITAL ADVISORS, INC.	0.14%	86.55K	5.47M	9.25K	+11.97%
Jun 30, 2025	PDT PARTNERS, LLC	0.15%	97.64K	6.17M	-4.56K	-4.46%
Jun 30, 2025	LAZARD ASSET MANAGEMENT LLC	0.16%	99.45K	6.28M	-3.76K	-3.64%
Jun 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.16%	102.24K	6.46B	16.17K	+18.79%
Jun 30, 2025	LOGOS GLOBAL MANAGEMENT LP	0.2%	130K	8.21M	130K	+100.00%
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.27%	170.83K	10.79M	106.99K	+167.59%
Jun 30, 2025	STEMPOINT CAPITAL LP	0.28%	176.75K	11.17M	142.94K	+422.69%
Jun 30, 2025	ARTISAN PARTNERS LIMITED PARTNERSHIP	0.27%	174.48K	11.03M	174.48K	+100.00%
Jun 30, 2025	CAPTION MANAGEMENT, LLC	0.2%	125K	7.9M	125K	+100.00%
Jun 30, 2025		0.15%	95.52K	6.04M	2.41K	+2.59%
Jun 30, 2025	INTEGRAL HEALTH ASSET MANAGEMENT, LLC	0.19%	120K	7.58M	120K	+100.00%
Jun 30, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.18%	115.12K	7.27M	64.56K	+127.70%
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.12%	77.98K	4.93M	20.83K	+36.45%
Jun 30, 2025	FMR LLC	3.07%	1.95M	123.44M	265.07K	+15.70%
Jun 30, 2025	CINCTIVE CAPITAL MANAGEMENT LP	0.11%	70.94K	4.48M	66.58K	+1,528.49%
Jun 30, 2025	POLAR CAPITAL HOLDINGS PLC	1.96%	1.25M	79.04M	750.87K	+150.17%
Jun 30, 2025	ROYAL BANK OF CANADA	0.31%	196.24K	12.4M	196.11K	+149,698.47%
Jun 30, 2025	MORGAN STANLEY	0.82%	524.48K	33.14B	20.43K	+4.05%
Jun 30, 2025	ABRDN PLC	0.11%	67.66K	4.28M	-40.47K	-37.43%
Jun 30, 2025	ALGERT GLOBAL LLC	0.09%	60.22K	3.81M	-1.24K	-2.02%
Jun 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.09%	57.22K	3.62M	2.29K	+4.16%
Jun 30, 2025	TD ASSET MANAGEMENT INC	0.09%	56K	3.54M	5.8K	+11.55%
Jun 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.08%	54.09K	3.42M	-301.62K	-84.79%
Jun 30, 2025	AXIOM INVESTORS LLC /DE	0.08%	52.46K	3.31M	52.46K	+100.00%
Jun 30, 2025	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.53%	338.8K	21.41M	-84.06K	-19.88%
Jun 30, 2025	BLACKROCK, INC.	9.84%	6.27M	396.05M	-587.22K	-8.57%
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	8.73%	5.56M	351.42M	-523.05K	-8.60%
Jun 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	1.35%	861.15K	54.42M	26.97K	+3.23%
Jun 30, 2025	JPMORGAN CHASE & CO	1.23%	783.56K	49.51M	639.92K	+445.50%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.06%	1.31M	82.87M	24.09K	+1.87%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.11%	1.34M	84.76M	142.34K	+11.87%
Jun 30, 2025	JANUS HENDERSON GROUP PLC	2.22%	1.41M	89.27M	-243.45K	-14.71%
Jun 30, 2025	FEDERATED HERMES, INC.	2.65%	1.69M	106.57M	94.62K	+5.94%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	2.72%	1.73M	109.55B	95.81K	+5.85%
Jun 30, 2025	STATE STREET CORP	3%	1.91M	120.54M	-63.13K	-3.20%
Jun 30, 2025	VANGUARD GROUP INC	5.64%	3.59M	226.8M	144.19K	+4.19%
Jun 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.38%	244K	15.42M	158.15K	+184.22%
Jun 30, 2025	ORBIMED ADVISORS LLC	0.39%	248.51K	15.7M	-131.49K	-34.60%
Jun 30, 2025	UBS GROUP AG	0.4%	252.58K	15.96M	-19.53K	-7.18%
Jun 30, 2025	COMERICA BANK	0.47%	301.66K	19.06M	56.91K	+23.25%
Jun 30, 2025	OPALEYE MANAGEMENT INC.	0.75%	475K	30.02M	-15K	-3.06%
Jun 30, 2025	CLEARBRIDGE INVESTMENTS, LLC	0.49%	312.45K	19.74M	312.45K	+100.00%
Jun 30, 2025	CANDRIAM S.C.A.	0.49%	312.45K	19.74M	20.98K	+7.20%
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.49%	314.89K	19.9M	300.78K	+2,131.38%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.54%	341K	21.55M	341K	+100.00%
Mar 31, 2025	JPMORGAN CHASE & CO	0.23%	143.64K	7.61M	-120.95K	-45.71%
Mar 31, 2025		0.23%	147.3K	7.8M	147.3K	+100.00%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.23%	146.59K	7.76M	-1.66K	-1.12%
Mar 31, 2025	BLACKROCK, INC.	10.87%	6.85M	363.1M	-95.96K	-1.38%
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	9.65%	6.08M	322.29M	0	0
Mar 31, 2025	PRIMECAP MANAGEMENT CO/CA/	9.18%	5.79M	306.55M	-783.87K	-11.93%
Mar 31, 2025	BAKER BROS. ADVISORS LP	8.89%	5.6M	296.87M	-479.77K	-7.89%
Mar 31, 2025	LOOMIS SAYLES & CO L P	0.96%	605.76K	32.09M	-12.72K	-2.06%
Mar 31, 2025	VANGUARD GROUP INC	5.46%	3.44M	182.48M	2.33K	+0.07%
Mar 31, 2025	NEA MANAGEMENT COMPANY, LLC	4.61%	2.91M	154.14M	0	0
Mar 31, 2025	PERCEPTIVE ADVISORS LLC	4.04%	2.55M	134.99M	-1.13M	-30.76%
Mar 31, 2025	STATE STREET CORP	3.13%	1.97M	104.39M	129.86K	+7.05%
Mar 31, 2025	FMR LLC	2.68%	1.69M	89.43M	1.58M	+1,392.70%
Mar 31, 2025	INVESCO LTD.	0.42%	261.9K	13.87M	-40.94K	-13.52%
Mar 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.41%	259.35K	13.85M	-116K	-30.91%
Mar 31, 2025	COMERICA BANK	0.39%	244.75K	12.96M	227.64K	+1,330.22%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.34%	217.38K	11.51M	202.12K	+1,324.60%
Mar 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.34%	216.19K	11.45M	120.96K	+127.01%
Mar 31, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0.28%	173.82K	9.21M	173.82K	+100.00%
Mar 31, 2025	JANE STREET GROUP, LLC	0.27%	170.1K	9.01M	72.1K	+73.57%
Mar 31, 2025	CORMORANT ASSET MANAGEMENT, LP	0.24%	150K	7.95M	-250K	-62.50%
Mar 31, 2025	CHECKPOINT CAPITAL L.P.	1.44%	907.24K	48.06M	179.26K	+24.62%
Mar 31, 2025	ALKEON CAPITAL MANAGEMENT LLC	1.3%	817.7K	43.31M	-350K	-29.97%
Mar 31, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	1.08%	678.76K	35.95M	-1.19M	-63.70%
Mar 31, 2025	NORTHERN TRUST CORP	0.85%	536.21K	28.4M	-9.11K	-1.67%
Mar 31, 2025	MARSHALL WACE, LLP	0.85%	535.1K	28.34M	-157.7K	-22.76%
Mar 31, 2025	MORGAN STANLEY	0.8%	504.05K	26.7M	-56.04K	-10.01%
Mar 31, 2025	POLAR CAPITAL HOLDINGS PLC	0.79%	500K	26.49M	-1M	-66.67%
Mar 31, 2025	OPALEYE MANAGEMENT INC.	0.78%	490K	25.96M	-10K	-2.00%
Mar 31, 2025	PANAGORA ASSET MANAGEMENT INC	0.22%	141.16K	7.48M	141.16K	+100.00%
Mar 31, 2025	SAMSARA BIOCAPITAL, LLC	0.22%	138.12K	7.32M	-34.53K	-20.00%
Mar 31, 2025	LORD, ABBETT & CO. LLC	0.21%	135.36K	7.17M	-25.29K	-15.74%
Mar 31, 2025	SOFINNOVA INVESTMENTS, INC.	0.71%	446.84K	23.67M	49.41K	+12.43%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.71%	445.43K	23.59M	5.18K	+1.18%
Mar 31, 2025	JANUS HENDERSON GROUP PLC	2.63%	1.66M	90.75M	435.8K	+35.73%
Mar 31, 2025	HOOD RIVER CAPITAL MANAGEMENT LLC	1.05%	659.43K	34.93M	15.74K	+2.45%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	2.6%	1.64M	86.76M	-174.3K	-9.62%
Mar 31, 2025	FEDERATED HERMES, INC.	2.52%	1.59M	84.32M	42.24K	+2.73%
Mar 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	2.31%	1.46M	77.23M	167.05K	+12.94%
Mar 31, 2025	WESTFIELD CAPITAL MANAGEMENT CO LP	2.13%	1.34M	71.04M	1.34M	+100.00%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.04%	1.29M	68.2M	31.37K	+2.50%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	1.9%	1.2M	63.52M	513.9K	+75.01%
Mar 31, 2025	ORBIMED ADVISORS LLC	0.6%	380K	20.13M	-20K	-5.00%
Mar 31, 2025	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.67%	422.87K	22.4M	42.33K	+11.12%
Mar 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.56%	355.71K	18.84M	217.35K	+157.09%
Mar 31, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.54%	337.61K	17.88M	63.71K	+23.26%
Mar 31, 2025	FRANKLIN RESOURCES INC	0.52%	326.16K	17.28M	57.96K	+21.61%
Mar 31, 2025	CANDRIAM S.C.A.	0.46%	291.47K	15.44M	-40.92K	-12.31%
Mar 31, 2025	SIREN, L.L.C.	0.44%	277.53K	14.7M	277.53K	+100.00%
Mar 31, 2025	UBS GROUP AG	0.43%	272.11K	14.41M	17.84K	+7.02%
Mar 31, 2024	ALPS ADVISORS INC	0.07%	42.42K	1.84M	2.2K	+5.48%
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	0.37%	218.66K	9.47M	97K	+79.74%
Mar 31, 2024	FRANKLIN RESOURCES INC	0.37%	220.91K	9.57M	215.03K	+3,659.45%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.44%	262.7K	11.38M	-8.3K	-3.06%
Mar 31, 2024	ARTISAN PARTNERS LIMITED PARTNERSHIP	0.46%	271.42K	11.76M	0	0
Mar 31, 2024	LORD, ABBETT & CO. LLC	0.47%	281.16K	12.18M	-2.36K	-0.83%
Mar 31, 2024	ASSENAGON ASSET MANAGEMENT S.A.	0.48%	285.65K	12.38M	-15.99K	-5.30%
Mar 31, 2024	NATIONAL BANK OF CANADA /FI/	0.62%	367.52K	14.38M	128.52K	+53.77%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.69%	406.75K	17.62M	9.06K	+2.28%
Mar 31, 2024	CAPTION MANAGEMENT, LLC	0.71%	419.3K	18.17M	-52.4K	-11.11%
Mar 31, 2024	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.8%	473.46K	20.51M	110.74K	+30.53%
Mar 31, 2024	PRICE T ROWE ASSOCIATES INC /MD/	0.81%	481.53K	20.87M	-90.76K	-15.86%
Mar 31, 2024	OPALEYE MANAGEMENT INC.	0.87%	515K	22.31M	-95K	-15.57%
Mar 31, 2024	CORMORANT ASSET MANAGEMENT, LP	0.93%	550K	23.83M	0	0
Mar 31, 2024	CANADA PENSION PLAN INVESTMENT BOARD	0.97%	577K	25M	310K	+116.10%
Mar 31, 2024	JANUS HENDERSON GROUP PLC	1.05%	621.43K	26.93M	-465	-0.07%
Mar 31, 2024	ORBIMED ADVISORS LLC	1.19%	704.84K	30.54M	168.2K	+31.34%
Mar 31, 2024	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	1.23%	730.64K	31.66M	578.8K	+381.18%
Mar 31, 2024	CHECKPOINT CAPITAL L.P.	1.39%	825.5K	35.77M	95.5K	+13.08%
Mar 31, 2024	DRIEHAUS CAPITAL MANAGEMENT LLC	1.44%	855.51K	37.07M	256.6K	+42.84%
Mar 31, 2024	COMMODORE CAPITAL LP	1.77%	1.05M	45.5M	-500K	-32.26%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	1.99%	1.18M	51.17M	61.58K	+5.50%
Mar 31, 2024	PICTET ASSET MANAGEMENT HOLDING SA	2.05%	1.21M	52.5M	47.72K	+4.10%
Mar 31, 2024	PRIMECAP MANAGEMENT CO/CA/	13.08%	7.75M	335.7M	-305.06K	-3.79%
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.05%	27.6K	1.2B	-10.2K	-26.98%
Mar 31, 2024	STIFEL FINANCIAL CORP	0.05%	27.94K	1.21M	-2.69K	-8.78%
Mar 31, 2024	FMR LLC	0.05%	29.02K	1.26M	-500.11K	-94.52%
Mar 31, 2024	NEW YORK STATE COMMON RETIREMENT FUND	0.06%	32.81K	1.42M	-63	-0.19%
Mar 31, 2024	STATE OF WISCONSIN INVESTMENT BOARD	0.06%	33.3K	1.44M	-4.11K	-10.99%
Mar 31, 2024	PROFUND ADVISORS LLC	0.06%	34.28K	1.49B	13.79K	+67.30%
Mar 31, 2024	CREDIT SUISSE AG/	0.07%	43.16K	1.87M	1.15K	+2.74%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.08%	47.42K	2.05B	588	+1.26%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.08%	47.62K	2.06M	8.39K	+21.37%
Mar 31, 2024	NAN FUNG GROUP HOLDINGS LTD	0.08%	49.12K	2.13M	9.05K	+22.59%
Mar 31, 2024	INTRINSIC EDGE CAPITAL MANAGEMENT LLC	0.08%	50K	2.17M	50K	+100.00%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.09%	53.43K	2.32M	-960	-1.77%
Mar 31, 2024	JPMORGAN CHASE & CO	0.09%	54.5K	2.36M	-23.1K	-29.76%
Mar 31, 2024	BNP PARIBAS ARBITRAGE, SNC	0.09%	56.01K	2.43M	-7.08K	-11.22%
Mar 31, 2024	JEFFERIES FINANCIAL GROUP INC.	0.12%	68.57K	2.97M	-13.5K	-16.45%
Mar 31, 2024	ALGERT GLOBAL LLC	0.12%	69.05K	2.99M	40.25K	+139.72%
Mar 31, 2024	WEDGE CAPITAL MANAGEMENT L L P/NC	0.12%	73.87K	3.2M	-2.63K	-3.44%
Mar 31, 2024	RHUMBLINE ADVISERS	0.13%	76.72K	3.32M	3.55K	+4.85%
Mar 31, 2024	HENNION & WALSH ASSET MANAGEMENT, INC.	0.15%	86.97K	3.77M	20.26K	+30.37%
Mar 31, 2024	INVESCO LTD.	0.15%	88.21K	3.82M	-47.53K	-35.01%
Mar 31, 2024	RICE HALL JAMES & ASSOCIATES, LLC	0.15%	89.73K	3.89M	121	+0.14%
Mar 31, 2024	CLEARBRIDGE INVESTMENTS, LLC	0.15%	90K	3.9M	-1.15K	-1.27%
Mar 31, 2024	SWISS NATIONAL BANK	0.16%	93.3K	4.04M	3.6K	+4.01%
Mar 31, 2024	JGP GLOBAL GESTAO DE RECURSOS LTDA.	0.18%	105.81K	4.58M	100.13K	+1,760.30%
Mar 31, 2024	RA CAPITAL MANAGEMENT, L.P.	9%	5.33M	230.97M	0	0
Mar 31, 2024	BAKER BROS. ADVISORS LP	10.81%	6.4M	277.24M	0	0
Mar 31, 2024	GHOST TREE CAPITAL, LLC	0.21%	125K	5.42M	125K	+100.00%
Mar 31, 2024	BARCLAYS PLC	0.22%	127.54K	5.53M	-123.88K	-49.27%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.24%	142.74K	6.18M	-934	-0.65%
Mar 31, 2024	NISA INVESTMENT ADVISORS, LLC	0.25%	145.29K	6.3M	144.04K	+11,467.75%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.28%	167.84K	7.27M	-12.38K	-6.87%
Mar 31, 2024	VOYA INVESTMENT MANAGEMENT LLC	0.29%	169.71K	7.35M	104.72K	+161.13%
Mar 31, 2024	UBS GROUP AG	0.29%	171.57K	7.43M	85.61K	+99.60%
Mar 31, 2024	WOODLINE PARTNERS LP	0.29%	172.21K	7.46M	97.36K	+130.07%
Mar 31, 2024	SAMSARA BIOCAPITAL, LLC	0.29%	172.65K	7.48M	0	0
Mar 31, 2024	MORGAN STANLEY	0.31%	182.87K	7.92M	-48.79K	-21.06%
Mar 31, 2024	SILVERARC CAPITAL MANAGEMENT, LLC	0.31%	183.78K	7.96M	9.53K	+5.47%
Mar 31, 2024	CITIGROUP INC	0.32%	190.52K	8.26M	136.22K	+250.87%
Mar 31, 2024	WELLINGTON MANAGEMENT GROUP LLP	0.33%	193.52K	8.39M	53.72K	+38.43%
Mar 31, 2024	UBS ASSET MANAGEMENT AMERICAS INC	0.35%	206.98K	8.97M	-2.96K	-1.41%
Mar 31, 2024	NORTHERN TRUST CORP	0.85%	502.86K	21.79M	1.76K	+0.35%
Mar 31, 2024	POLAR CAPITAL HOLDINGS PLC	2.53%	1.5M	65M	-250K	-14.29%
Mar 31, 2024	ROCK SPRINGS CAPITAL MANAGEMENT LP	2.57%	1.52M	65.99M	0	0
Mar 31, 2024	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	3.7%	2.19M	94.9M	-181.13K	-7.64%
Mar 31, 2024	NEA MANAGEMENT COMPANY, LLC	4.91%	2.91M	126.09M	0	0
Mar 31, 2024	GOLDMAN SACHS GROUP INC	8.63%	5.11M	221.49M	63.67K	+1.26%
Mar 31, 2024	BLACKROCK INC.	11.03%	6.53M	282.93M	177.9K	+2.80%
Mar 31, 2024	FEDERATED HERMES, INC.	2.81%	1.66M	71.98M	-649.86K	-28.12%
Mar 31, 2024	STATE STREET CORP	5.09%	3.01M	130.59M	807.82K	+36.62%
Mar 31, 2024	PERCEPTIVE ADVISORS LLC	5.52%	3.27M	141.63M	1.11M	+51.74%
Mar 31, 2024	VANGUARD GROUP INC	5.58%	3.3M	143.17M	77.21K	+2.39%
Dec 31, 2023	D. E. SHAW & CO., INC.	0.22%	128.49K	5.91M	128.49K	+100.00%
Dec 31, 2023	INVESCO LTD.	0.23%	135.73K	6.24M	107.36K	+378.36%
Dec 31, 2023	WELLINGTON MANAGEMENT GROUP LLP	0.24%	139.8K	6.43M	139.8K	+100.00%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.25%	143.67K	6.6M	2.08K	+1.47%
Dec 31, 2023	PRIMECAP MANAGEMENT CO/CA/	13.91%	8.05M	370.18M	-214.77K	-2.60%
Dec 31, 2023	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	0.26%	151.84K	6.98M	-25.16K	-14.21%
Dec 31, 2023	SAMSARA BIOCAPITAL, LLC	0.3%	172.65K	7.94M	-172.65K	-50.00%
Dec 31, 2023	SILVERARC CAPITAL MANAGEMENT, LLC	0.3%	174.25K	8.01M	-86.29K	-33.12%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.31%	180.22K	8.28M	2.85K	+1.60%
Dec 31, 2023	VICTORY CAPITAL MANAGEMENT INC	0.32%	182.3K	8.38M	162.25K	+809.21%
Dec 31, 2023	JANE STREET GROUP, LLC	0.32%	184.36K	8.47M	40.36K	+28.03%
Dec 31, 2023	UBS ASSET MANAGEMENT AMERICAS INC	0.36%	209.94K	9.65M	-127.33K	-37.75%
Dec 31, 2023	MORGAN STANLEY	0.4%	231.66K	10.65M	-204.75K	-46.92%
Dec 31, 2023	NATIONAL BANK OF CANADA /FI/	0.41%	239K	10.79M	108K	+82.44%
Dec 31, 2023	BARCLAYS PLC	0.43%	251.42K	11.56M	10.15K	+4.21%
Dec 31, 2023	CANADA PENSION PLAN INVESTMENT BOARD	0.46%	267K	12.27M	267K	+100.00%
Dec 31, 2023	ARTISAN PARTNERS LIMITED PARTNERSHIP	0.47%	271.42K	12.48M	271.42K	+100.00%
Dec 31, 2023	LORD, ABBETT & CO. LLC	0.49%	283.52K	13.03M	283.52K	+100.00%
Dec 31, 2023	ASSENAGON ASSET MANAGEMENT S.A.	0.52%	301.64K	13.87M	-105.65K	-25.94%
Dec 31, 2023	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.63%	362.72K	16.67M	342.35K	+1,680.91%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.69%	397.69K	18.28M	12.94K	+3.36%
Dec 31, 2023	CAPTION MANAGEMENT, LLC	0.82%	471.7K	21.68M	471.7K	+100.00%
Dec 31, 2023	VR ADVISER, LLC	0.86%	495.98K	22.8M	-594.02K	-54.50%
Dec 31, 2023	NORTHERN TRUST CORP	0.87%	501.09K	23.04M	-2.93K	-0.58%
Dec 31, 2023	FMR LLC	0.91%	529.13K	24.32M	-339.34K	-39.07%
Dec 31, 2023	ORBIMED ADVISORS LLC	0.93%	536.64K	24.67M	-47K	-8.05%
Dec 31, 2023	CORMORANT ASSET MANAGEMENT, LP	0.95%	550K	25.28M	-300K	-35.29%
Dec 31, 2023	PRICE T ROWE ASSOCIATES INC /MD/	0.99%	572.3K	26.31M	361.95K	+172.07%
Dec 31, 2023	DRIEHAUS CAPITAL MANAGEMENT LLC	1.03%	598.91K	27.53M	324.38K	+118.16%
Dec 31, 2023	OPALEYE MANAGEMENT INC.	1.05%	610K	28.04M	-43K	-6.59%
Dec 31, 2023	JANUS HENDERSON GROUP PLC	1.07%	621.89K	28.59M	-443.85K	-41.65%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.93%	1.12M	51.45M	74.07K	+7.09%
Dec 31, 2023		1.26%	730K	33.56M	730K	+100.00%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	8.72%	5.05M	232.05M	-112.61K	-2.18%
Dec 31, 2023	RA CAPITAL MANAGEMENT, L.P.	9.21%	5.33M	245.04M	-345.66K	-6.09%
Dec 31, 2023	BLACKROCK INC.	10.98%	6.35M	291.99M	151.87K	+2.45%
Dec 31, 2023	BAKER BROS. ADVISORS LP	11.06%	6.4M	294.13M	-303.98K	-4.54%
Dec 31, 2023	ROCK SPRINGS CAPITAL MANAGEMENT LP	2.63%	1.52M	70.01M	-74.23K	-4.65%
Dec 31, 2023	COMMODORE CAPITAL LP	2.68%	1.55M	71.25M	-525K	-25.30%
Dec 31, 2023	POLAR CAPITAL HOLDINGS PLC	3.02%	1.75M	80.45M	-750K	-30.00%
Dec 31, 2023	PERCEPTIVE ADVISORS LLC	3.72%	2.15M	99.02M	1.77M	+465.64%
Dec 31, 2023	STATE STREET CORP	3.81%	2.21M	101.41M	-159.84K	-6.76%
Dec 31, 2023	FEDERATED HERMES, INC.	3.99%	2.31M	106.23M	-30.38K	-1.30%
Dec 31, 2023	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	4.1%	2.37M	109.01M	0	0
Dec 31, 2023	NEA MANAGEMENT COMPANY, LLC	5.03%	2.91M	133.77M	0	0
Dec 31, 2023	VANGUARD GROUP INC	5.58%	3.23M	148.34M	212.37K	+7.04%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	0.17%	96.95K	4.46M	0	0
Dec 31, 2023	CITADEL ADVISORS LLC	0.2%	113.92K	5.24M	-141.52K	-55.40%
Dec 31, 2023	RAFFERTY ASSET MANAGEMENT, LLC	0.21%	121.65K	5.59M	-41.15K	-25.28%

Insiders

Among the RYTM insiders holding of 0.65% of the stake in company, RA CAPITAL MANAGEMENT, L.P., , holds the largest shares of 4.36M. FOLEY TODD, director, is the second largest RYTM insider with ownership of 909.26K shares. MEEKER DAVID P, President and CEO, stands third with possession of 201.83K shares of that stake.

Insiders	Designation	Shares Held
RA CAPITAL MANAGEMENT, L.P.		4.36M
FOLEY TODD	director	909.26K
MEEKER DAVID P	President and CEO	201.83K
SMITH HUNTER C	Chief Financial Officer	116.92K
DESIKAN NITHYA	Chief Commercial Officer	43.6K
MAZABRAUD YANN	EVP, Head of International	37.66K
CRAMER PAMELA J.	Chief Human Resources Officer	20.81K
SHULMAN JOSEPH	Chief Technical Officer	8.51K
ROBERTS WILLIAM T.	Chief Accounting Officer	7.87K
LEE JENNIFER KAYDEN	EVP, Head of North America	5.86K
CHIEN JENNIFER	EVP, Head of North America	4.94K
GARFIELD ALASTAIR	Chief Scientific Officer	3.13K
MCGIRR DAVID W J	director	3K
GOOD JENNIFER L	director	3K
TETRAULT LYNN A.	director	3K
GERMAN CHRISTOPHER PAUL	Corporate Controller & CAO	922

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Dec 11, 2025	CRAMER PAMELA J.	SALE	111.00	3.35K	371.85K	20.81K
Nov 20, 2025	CRAMER PAMELA J.	SALE	105.00	3.35K	351.75K	20.81K
Nov 10, 2025	CRAMER PAMELA J.	SALE	100.00	3.52K	351.5K	20.81K
Nov 07, 2025	CRAMER PAMELA J.	SALE	98.82	19.35K	1.91M	20.81K
Oct 30, 2025	SHULMAN JOSEPH	SALE	115.24	9.75K	1.12M	8.51K
Oct 28, 2025	SHULMAN JOSEPH	SALE	115.01	2.82K	323.75K	8.51K
Oct 16, 2025	SHULMAN JOSEPH	SALE	112.81	3.41K	384.91K	8.51K
Sep 02, 2025	SHULMAN JOSEPH	SALE	105.30	16.78K	1.77M	8.51K
Aug 21, 2025	SHULMAN JOSEPH	SALE	100.07	4.19K	419.09K	8.51K
Aug 13, 2025	SMITH HUNTER C	SALE	96.00	3.48K	333.79K	116.92K
Aug 12, 2025	GERMAN CHRISTOPHER PAUL	SALE	95.00	1.5K	142.5K	922
Aug 12, 2025	SMITH HUNTER C	SALE	96.33	24.61K	2.37M	116.92K
Aug 11, 2025	SHULMAN JOSEPH	SALE	90.08	3.98K	358.89K	8.51K
Jul 29, 2025	CRAMER PAMELA J.	SALE	85.93	1.52K	130.61K	20.81K
Jul 09, 2025	SHULMAN JOSEPH	SALE	80.00	3.99K	318.8K	8.51K
Jul 09, 2025	CRAMER PAMELA J.	SALE	80.00	3.52K	281.28K	19.21K
Jul 09, 2025	GERMAN CHRISTOPHER PAUL	SALE	85.00	1.85K	157.25K	922
Jul 09, 2025	SMITH HUNTER C	SALE	84.50	23.4K	1.98M	116.92K
Jul 02, 2025	GARFIELD ALASTAIR	SALE	64.60	6	387.6	3.13K
Jun 10, 2025	GERMAN CHRISTOPHER PAUL	SALE	67.19	2.07K	139.02K	1.89K
Jun 06, 2025	CRAMER PAMELA J.	SALE	68.05	7.03K	478.43K	19.21K
Jun 03, 2025	MCGIRR DAVID W J	SALE	65.64	9.87K	648.09K	3K
Jun 03, 2025	MEEKER DAVID P	SALE	65.60	274	17.98K	201.83K
May 30, 2025	SMITH HUNTER C	SALE	61.52	18.99K	1.17M	109.93K
Apr 29, 2025	MAZABRAUD YANN	SALE	65.08	6.75K	438.95K	37.66K
Apr 29, 2025	CRAMER PAMELA J.	SALE	65.09	7.03K	457.66K	19.21K
Apr 08, 2025	MAZABRAUD YANN	SALE	61.54	9.31K	573.06K	22.62K
Apr 08, 2025	CRAMER PAMELA J.	SALE	62.00	7.03K	435.86K	19.21K
Mar 21, 2025	GERMAN CHRISTOPHER PAUL	SALE	54.23	344	18.66K	2.89K
Mar 14, 2025	MAZABRAUD YANN	SALE	51.72	55.8K	2.89M	40.37K
Feb 19, 2025	CRAMER PAMELA J.	SALE	57.22	982	56.19K	19.21K
Feb 19, 2025	SMITH HUNTER C	SALE	57.22	2.22K	126.74K	109.93K
Feb 19, 2025	SHULMAN JOSEPH	SALE	57.22	1.23K	70.27K	8.51K
Feb 19, 2025	MEEKER DAVID P	SALE	57.22	9.9K	566.25K	201.28K
Feb 19, 2025	LEE JENNIFER KAYDEN	SALE	57.22	2.04K	116.44K	5.86K
Feb 19, 2025	GERMAN CHRISTOPHER PAUL	SALE	57.22	635	36.33K	2.07K
Feb 13, 2025	LEE JENNIFER KAYDEN	SALE	58.00	1.21K	69.89K	2.39K
Feb 12, 2025	SMITH HUNTER C	SALE	56.22	12	674.64	105.54K
Feb 12, 2025	SHULMAN JOSEPH	SALE	57.09	7	399.63	5.61K
Feb 12, 2025	LEE JENNIFER KAYDEN	SALE	56.39	1.21K	67.95K	3.6K
Feb 11, 2025	LEE JENNIFER KAYDEN	SALE	57.50	4	230	5.41K
Feb 11, 2025	SHULMAN JOSEPH	SALE	57.54	3	172.62	6
Feb 11, 2025	CRAMER PAMELA J.	SALE	57.54	3	172.62	16.89K
Feb 11, 2025	SMITH HUNTER C	SALE	57.53	5	287.65	106.3K
Feb 10, 2025	LEE JENNIFER KAYDEN	SALE	59.34	2.3K	136.19K	4.41K
Feb 05, 2025	LEE JENNIFER KAYDEN	SALE	61.95	200	12.39K	972
Feb 04, 2025	SHULMAN JOSEPH	SALE	59.43	1.28K	76.13K	2.66K
Feb 04, 2025	SMITH HUNTER C	SALE	59.43	1.68K	99.72K	101.19K
Feb 04, 2025	CRAMER PAMELA J.	SALE	59.43	902	53.61K	15.25K
Feb 04, 2025	LEE JENNIFER KAYDEN	SALE	59.43	1.45K	86K	4.04K
Feb 04, 2025	MEEKER DAVID P	SALE	59.43	4.28K	254.24K	189.93K
Nov 11, 2024	SHULMAN JOSEPH	SALE	67.83	700	47.48K	0
Nov 11, 2024	LEE JENNIFER KAYDEN	SALE	68.43	200	13.69K	972
Nov 07, 2024	CRAMER PAMELA J.	SALE	65.00	4.69K	304.72K	13.5K
Nov 06, 2024	CRAMER PAMELA J.	SALE	60.00	4.69K	281.22K	13.5K
Sep 17, 2024	GOOD JENNIFER L	SALE	52.40	31.75K	1.66M	3K
Sep 10, 2024	TETRAULT LYNN A.	SALE	50.60	350	17.71K	3K
Sep 09, 2024	TETRAULT LYNN A.	SALE	50.04	3.2K	160.07K	3K
Sep 09, 2024	CRAMER PAMELA J.	SALE	50.03	4.1K	205.06K	13.5K
Sep 09, 2024	GOOD JENNIFER L	SALE	50.45	37.24K	1.88M	3K
Aug 26, 2024	CRAMER PAMELA J.	SALE	50.01	3.2K	160.02K	13.5K
Aug 26, 2024	TETRAULT LYNN A.	SALE	50.01	4.3K	215.03K	3K
Aug 26, 2024	GOOD JENNIFER L	SALE	50.01	14.51K	725.53K	3K
Aug 12, 2024	TETRAULT LYNN A.	SALE	45.37	407	18.47K	3K
Aug 09, 2024	CRAMER PAMELA J.	SALE	45.62	2.1K	95.99K	13.5K
Jul 29, 2024	CRAMER PAMELA J.	SALE	49.06	1.4K	68.44K	31.74K
Jul 16, 2024	SHULMAN JOSEPH	SALE	53.00	10.47K	554.82K	30
Jul 12, 2024	SHULMAN JOSEPH	SALE	50.01	5.31K	265.72K	30
May 09, 2024	SHULMAN JOSEPH	SALE	39.10	500	19.55K	30
Apr 02, 2024	GERMAN CHRISTOPHER PAUL	SALE	41.76	368	15.37K	795
Mar 21, 2024	SHULMAN JOSEPH	SALE	40.34	18.24K	735.6K	30
Mar 20, 2024	LEE JENNIFER KAYDEN	SALE	39.33	9.07K	356.57K	6.85K
Mar 19, 2024	MAZABRAUD YANN	SALE	39.22	16K	627.52K	24.5K
Mar 19, 2024	LEE JENNIFER KAYDEN	SALE	39.22	15.52K	608.5K	25.09K
Mar 19, 2024	CRAMER PAMELA J.	SALE	39.22	15.52K	608.5K	30.01K
Mar 19, 2024	SMITH HUNTER C	SALE	39.22	15.52K	608.5K	97.94K
Mar 19, 2024	SHULMAN JOSEPH	SALE	39.22	15.52K	608.5K	18.27K
Mar 19, 2024	MEEKER DAVID P	SALE	39.22	45.49K	1.78M	174.61K
Feb 14, 2024	SHULMAN JOSEPH	SALE	50.01	1.09K	54.46K	30
Feb 13, 2024	LEE JENNIFER KAYDEN	SALE	49.83	615	30.65K	6.85K
Feb 13, 2024	MAZABRAUD YANN	SALE	49.84	957	47.7K	6.75K
Feb 13, 2024	SHULMAN JOSEPH	SALE	49.84	473	23.57K	2.98K
Feb 13, 2024	SMITH HUNTER C	SALE	49.82	709	35.32K	79.7K
Feb 12, 2024	LEE JENNIFER KAYDEN	SALE	51.38	1.02K	52.56K	7.47K
Feb 12, 2024	CRAMER PAMELA J.	SALE	51.38	696	35.76K	11.77K
Feb 12, 2024	SHULMAN JOSEPH	SALE	51.38	791	40.64K	3.46K
Feb 12, 2024	SMITH HUNTER C	SALE	51.38	1.21K	62.12K	80.41K
Feb 12, 2024	MAZABRAUD YANN	SALE	51.38	1.59K	81.9K	7.7K
Feb 09, 2024	SHULMAN JOSEPH	SALE	51.52	100	5.15K	2.69K
Feb 01, 2024	SHULMAN JOSEPH	SALE	45.06	1.32K	59.66K	2.61K
Feb 01, 2024	SMITH HUNTER C	SALE	45.06	1.62K	72.82K	75.22K
Feb 01, 2024	MEEKER DAVID P	SALE	45.06	4.36K	196.51K	121.1K
Feb 01, 2024	LEE JENNIFER KAYDEN	SALE	45.06	1.49K	67.23K	3.02K
Feb 01, 2024	CRAMER PAMELA J.	SALE	45.06	946	42.63K	10.12K
Dec 28, 2023	SHULMAN JOSEPH	SALE	50.00	7.93K	396.32K	0
Dec 27, 2023	SHULMAN JOSEPH	SALE	50.01	5.02K	250.8K	1.13K
Dec 06, 2023	SMITH HUNTER C	SALE	40.00	20K	800K	61.41K
Dec 05, 2023	SMITH HUNTER C	SALE	35.06	7.03K	246.36K	61.41K
Nov 24, 2023	SMITH HUNTER C	SALE	35.02	10.97K	384.34K	61.41K
Nov 14, 2023	SMITH HUNTER C	SALE	30.38	12K	364.57K	61.41K
Nov 14, 2023	LEE JENNIFER KAYDEN	SALE	32.01	13.68K	437.82K	0
Nov 14, 2023	SHULMAN JOSEPH	SALE	32.07	27.89K	894.33K	3.74K
Nov 09, 2023	LEE JENNIFER KAYDEN	SALE	28.00	1.72K	48.13K	1.65K
Nov 08, 2023	LEE JENNIFER KAYDEN	SALE	29.31	2.23K	65.46K	1.65K
Nov 03, 2023	LEE JENNIFER KAYDEN	SALE	28.00	80	2.24K	1.65K
Sep 05, 2023	LEE JENNIFER KAYDEN	SALE	28.05	6.17K	172.96K	1.65K
Aug 09, 2023	LEE JENNIFER KAYDEN	SALE	24.66	1.72K	42.37K	3.29K
Aug 07, 2023	LEE JENNIFER KAYDEN	SALE	24.18	11.22K	271.35K	3.29K
Jul 26, 2023	CRAMER PAMELA J.	SALE	17.64	930	16.41K	8.42K
Mar 29, 2023	ROBERTS WILLIAM T.	SALE	17.50	912	15.96K	7.87K
Feb 14, 2023	MAZABRAUD YANN	SALE	27.03	1.18K	31.81K	3.83K
Feb 14, 2023	SMITH HUNTER C	SALE	26.87	702	18.86K	59.41K
Feb 14, 2023	CHIEN JENNIFER	SALE	26.87	635	17.06K	4.94K
Feb 14, 2023	SHULMAN JOSEPH	SALE	26.87	554	14.89K	3.74K
Feb 09, 2023	MAZABRAUD YANN	SALE	27.66	1.55K	42.82K	2.99K
Feb 09, 2023	SMITH HUNTER C	SALE	27.66	1.4K	38.67K	57.78K
Feb 09, 2023	ROBERTS WILLIAM T.	SALE	27.66	959	26.53K	6.29K
Feb 09, 2023	CHIEN JENNIFER	SALE	27.66	1.19K	32.97K	3.56K
Feb 09, 2023	SHULMAN JOSEPH	SALE	27.66	921	25.47K	2.74K
Feb 09, 2023	CRAMER PAMELA J.	SALE	27.66	834	23.07K	6.15K
Aug 19, 2022	CRAMER PAMELA J.	SALE	24.83	13.49K	335.03K	2.22K
Jul 26, 2022	CRAMER PAMELA J.	SALE	11.68	901	10.52K	2.22K
Jun 30, 2022	SMITH HUNTER C	SALE	4.08	7.55K	30.79K	57.61K
Mar 29, 2022	ROBERTS WILLIAM T.	SALE	11.13	1.02K	11.39K	1.48K
Feb 15, 2022	CHIEN JENNIFER	SALE	6.10	722	4.4K	1.31K
Feb 15, 2022	SHULMAN JOSEPH	SALE	6.10	557	3.4K	1.01K
Feb 15, 2022	MAZABRAUD YANN	SALE	6.10	934	5.7K	1.1K
Feb 15, 2022	SMITH HUNTER C	SALE	6.10	833	5.08K	40.16K
Mar 30, 2021	MEEKER DAVID P	PURCHASE	20.17	10K	201.71K	111.34K
Mar 15, 2021	FOLEY TODD	SALE	25.10	1M	25.1M	909.26K
Dec 03, 2020	RA CAPITAL MANAGEMENT, L.P.	SALE	28.75	44.74K	1.29M	4.36M
Dec 02, 2020	RA CAPITAL MANAGEMENT, L.P.	SALE	32.23	12.06K	388.69K	4.57M
Aug 31, 2020	DESIKAN NITHYA	SALE	30.00	25K	750K	43.6K
Jul 02, 2020	RA CAPITAL MANAGEMENT, L.P.	SALE	22.04	44.15K	972.97K	5.14M
Jul 01, 2020	RA CAPITAL MANAGEMENT, L.P.	SALE	21.87	25.53K	558.31K	5.18M
Jun 30, 2020	RA CAPITAL MANAGEMENT, L.P.	SALE	22.15	61.9K	1.37M	5.21M
Jun 29, 2020	RA CAPITAL MANAGEMENT, L.P.	SALE	22.19	52.05K	1.15M	5.27M
Jun 26, 2020	RA CAPITAL MANAGEMENT, L.P.	SALE	23.31	86.71K	2.02M	5.32M
Jun 26, 2020	FOLEY TODD	SALE	25.04	300	7.51K	1.91M
Jun 25, 2020	RA CAPITAL MANAGEMENT, L.P.	SALE	25.05	11.57K	289.77K	5.41M
Jun 25, 2020	FOLEY TODD	SALE	25.41	17.95K	456.03K	1.91M
Jun 24, 2020	FOLEY TODD	SALE	25.34	97.39K	2.47M	1.93M
Jun 05, 2020	FOLEY TODD	SALE	20.00	1.9K	37.92K	2.02M
Jun 03, 2020	FOLEY TODD	SALE	20.27	18.25K	369.83K	2.03M
Jun 02, 2020	FOLEY TODD	SALE	20.23	15.58K	315.14K	2.05M
Jun 01, 2020	FOLEY TODD	SALE	20.08	10.54K	211.54K	2.06M
May 28, 2020	FOLEY TODD	SALE	20.19	19.15K	386.68K	2.07M
May 27, 2020	FOLEY TODD	SALE	20.13	10.15K	204.28K	2.09M
May 26, 2020	FOLEY TODD	SALE	20.47	44.42K	909.3K	2.1M
May 22, 2020	FOLEY TODD	SALE	20.13	26.91K	541.62K	2.14M
May 21, 2020	FOLEY TODD	SALE	20.25	25.59K	518.28K	2.17M
May 20, 2020	FOLEY TODD	SALE	20.01	10.53K	210.65K	2.2M
May 19, 2020	FOLEY TODD	SALE	20.00	2.63K	52.66K	2.21M
May 18, 2020	FOLEY TODD	SALE	20.00	21.35K	426.98K	2.21M
May 13, 2020	FOLEY TODD	SALE	20.04	1.84K	36.81K	2.23M
May 08, 2020	FOLEY TODD	SALE	20.05	6.63K	132.99K	2.28M

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES134.36K19

NET SHARES-134.36K19

SHARES HELD538.56K19

% NET SHARES-124.95%0%

Frequently Asked Questions