How many institutions own RNA stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own RNA shares is 305, representing 107.41% of the company's common stock.

Who are the major shareholders selling Avidity Biosciences, Inc. stock?

AVORO CAPITAL ADVISORS LLC, in the last quarter, reduced its stake in RNA by -28.65% restricting it's holding to 5.46 million shares of worth nearly $393.47M. JANUS HENDERSON GROUP PLC also lessened -52.22% of the RNA shares from its portfolio, reducing its holding to 6.94 million shares of worth $500.56M. LOGOS GLOBAL MANAGEMENT LP also shunned RNA shares holding by -16.67% last quarter which brought its holding to 500 thousand shares worth $36.07M.

Investors who are buying RNA stock?

As per its latest 13F filing, FIL LTD increased its stake in RNA by 100% in the last quarter. The institutional holder raised its holding to 1.14 million shares having worth more than $82.52M. ALLIANCEBERNSTEIN L.P. also added 741.7% more shares of RNA to its portfolio, raising its holding to 1.05 million shares of worth $75.55M. TIG ADVISORS, LLC also increased its RNA shares holding by 100% which brought its holding to 1.8 million shares worth $129.96M.

RNA's major insiders: who are they?

The insider with the most stakes in RNA is RTW INVESTMENTS, LP , 10 percent owner at the company. Additionally, RNA stock is highly held by Cormorant Asset Management, LP and President and CEO Boyce Sarah among others.

Did an insider recently sell RNA stock?

Company executives, directors, and other insiders own 4.79% percent of Avidity Biosciences, Inc.'s stock. Within the last six months, there have been 24 transaction(s) in which RNA insiders have sold stock, totaling 182.01K shares. Insiders that have sold shares include MCCARTHY TERESA, LEVIN ARTHUR A, and HUGHES STEVEN GEORGE.

Which insider recently purchased RNA stock?

There have been 0 transaction(s) during the past 6-months in which Avidity Biosciences, Inc. insiders have bought stock, totalling 0 shares

How much of RNA does insiders own?

Around 2.2M Avidity Biosciences, Inc. shares are held by insiders, which represents about 4.79% of RNA stock.

Who is the insider with the largest stake?

RNA 10 percent owner, RTW INVESTMENTS, LP holds the largest portfolio of the company's shares. RNA shares owned by RTW total nearly 4.8 million.

Which institution holds the most shares in RNA?

FIL LTD is the largest institutional owner in RNA which holds 1.14 million shares worth $82.52M or 0.83% of the total RNA shares outstanding followed by ALLIANCEBERNSTEIN L.P. with ownership of 1.05 million shares representing 0.76% of the RNA ownership. TIG ADVISORS, LLC is the third largest stakeholder with 1.8 million shares or 1.31% of the ownership worth more than $129.96M.

Is Avidity Biosciences, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the RNA is concerned, it is a stock which is optionable.

Is there a short position on RNA's shares?

Number of RNA shares short is 16.21M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding RNA shares are there?

As of today, 128.65M shares of RNA are outstanding.

Is there many float in RNA stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, RNA has 98.07M shares in float.

RNA short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for RNA is 6.27.

Avidity Biosciences (RNA) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares12.6

Short Percent Of Float12.71

Shares Outstanding128.65M

Shares Float98.07M

Shares Short16.21M

Short Ratio6.27

12.71%

Short % of Float

12.6%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

4.79% Percentage of Shares held by All Insiders

107.41% Percentage of Shares held by All Institutions

112.81% Percentage of Float held by Institutions

305

Number of Institutions Holding Shares

Institutional Ownership

About 107.41% of RNA shares are held by financial institutions. FIL LTD is the top corporate investor, holding 1.14M shares valued at $82.52M. A 0.83% stake in Avidity Biosciences, Inc. is owned by the company. ALLIANCEBERNSTEIN L.P. owns 1.05M shares valued at $75.55M, which translates its holding of 0.76% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	FIL LTD	0.83%	1.14M	82.52M	1.14M	+100.00%
Dec 31, 2025	ALLIANCEBERNSTEIN L.P.	0.76%	1.05M	75.55M	922.97K	+741.70%
Dec 31, 2025	TIG ADVISORS, LLC	1.31%	1.8M	129.96M	1.8M	+100.00%
Dec 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.91%	2.63M	189.77M	1.43M	+119.25%
Dec 31, 2025	BELLEVUE GROUP AG	1.91%	2.63M	189.77M	478.11K	+22.21%
Dec 31, 2025	HBK INVESTMENTS L P	3.17%	4.37M	314.85M	4.37M	+100.00%
Dec 31, 2025	AVORO CAPITAL ADVISORS LLC	3.96%	5.46M	393.47M	-2.19M	-28.65%
Dec 31, 2025	PENTWATER CAPITAL MANAGEMENT LP	4.37%	6.03M	434.69M	6.03M	+100.00%
Dec 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	4.38%	6.04M	435.71M	6.04M	+100.00%
Dec 31, 2025	JANUS HENDERSON GROUP PLC	5.03%	6.94M	500.56M	-7.58M	-52.22%
Dec 31, 2025	RA CAPITAL MANAGEMENT, L.P.	6.27%	8.64M	623.28M	0	0
Dec 31, 2025	BLACKROCK, INC.	9.32%	12.85M	926.93M	3.65M	+39.64%
Dec 31, 2025	VANGUARD GROUP INC	9.9%	13.65M	984.52M	429.49K	+3.25%
Dec 31, 2025	CREDIT INDUSTRIEL ET COMMERCIAL	0.12%	168K	12.12M	168K	+100.00%
Dec 31, 2025	PSQUARED ASSET MANAGEMENT AG	0.12%	168.42K	12.15M	168.42K	+100.00%
Dec 31, 2025	ATHOS CAPITAL LTD	0.13%	184.56K	13.31M	184.56K	+100.00%
Dec 31, 2025	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	0.13%	185K	13.34M	185K	+100.00%
Dec 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.14%	188.81K	13.62M	14.81K	+8.51%
Dec 31, 2025	VESTCOR INC	0.15%	200K	14.43M	200K	+100.00%
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	1.56%	2.16M	155.6M	2.13M	+7,182.42%
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	1.03%	1.43M	102.94M	1.23M	+628.11%
Dec 31, 2025	GABELLI & CO INVESTMENT ADVISERS, INC.	0.22%	303.03K	21.86M	303.03K	+100.00%
Dec 31, 2025	BOUSSARD & GAVAUDAN INVESTMENT MANAGEMENT LLP	0.24%	328.2K	23.68M	328.2K	+100.00%
Dec 31, 2025	GABELLI FUNDS LLC	0.24%	328.62K	23.7M	328.62K	+100.00%
Dec 31, 2025	LOGOS GLOBAL MANAGEMENT LP	0.36%	500K	36.07M	-100K	-16.67%
Dec 31, 2025	EVENTIDE ASSET MANAGEMENT, LLC	0.38%	524.64K	37.84M	148.65K	+39.54%
Dec 31, 2025	BARCLAYS PLC	0.39%	531.2K	38.32M	178.92K	+50.79%
Dec 31, 2025	SCULPTOR CAPITAL LP	0.41%	566K	40.83M	566K	+100.00%
Dec 31, 2025	HIGHBRIDGE CAPITAL MANAGEMENT LLC	0.42%	585.55K	42.24M	585.55K	+100.00%
Dec 31, 2025	LMR PARTNERS LLP	0.43%	598.53K	43.17M	598.53K	+100.00%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.44%	610.55K	44.04M	583.26K	+2,137.17%
Dec 31, 2025	NEUBERGER BERMAN GROUP LLC	0.45%	622.44K	44.9M	461K	+285.57%
Dec 31, 2025	VERITION FUND MANAGEMENT LLC	0.49%	680.72K	49.1M	644.89K	+1,800.02%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	0.51%	706.67K	50.97M	-1.02M	-59.04%
Dec 31, 2025	TUDOR INVESTMENT CORP ET AL	0.53%	733.01K	52.87M	733.01K	+100.00%
Dec 31, 2025	JPMORGAN CHASE & CO	0.6%	820.99K	59.22M	-78.57K	-8.73%
Dec 31, 2025	SOROS FUND MANAGEMENT LLC	0.61%	840.98K	60.66M	840.98K	+100.00%
Dec 31, 2025	WESTCHESTER CAPITAL MANAGEMENT, LLC	0.7%	962.66K	69.44M	962.66K	+100.00%
Dec 31, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	0.71%	983.13K	70.91M	358.13K	+57.30%
Dec 31, 2025	MORGAN STANLEY	0.79%	1.09M	78.8M	400.97K	+57.98%
Dec 31, 2025	GLAZER CAPITAL, LLC	1.79%	2.47M	177.96M	2.47M	+100.00%
Dec 31, 2025	NORGES BANK	2.21%	3.05M	219.74M	3.05M	+100.00%
Dec 31, 2025	ORBIMED ADVISORS LLC	0.45%	619.53K	44.69M	-1.02M	-62.20%
Dec 31, 2025	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.47%	642.22K	46.32M	642.22K	+100.00%
Dec 31, 2025	WOODLINE PARTNERS LP	0.49%	671.62K	48.44M	347.85K	+107.44%
Dec 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.52%	723.12K	52.16M	-9.34M	-92.82%
Dec 31, 2025	SQUAREPOINT OPS LLC	0.63%	868.2K	62.62M	868.2K	+100.00%
Dec 31, 2025	MAN GROUP PLC	0.65%	898.28K	64.79M	868.83K	+2,950.18%
Dec 31, 2025	TANG CAPITAL MANAGEMENT LLC	0.65%	900K	64.92M	900K	+100.00%
Dec 31, 2025	NEXPOINT ASSET MANAGEMENT, L.P.	0.67%	923.95K	66.64M	923.95K	+100.00%
Dec 31, 2025	CASDIN CAPITAL, LLC	0.73%	1M	72.13M	-780K	-43.82%
Dec 31, 2025	NORTHERN TRUST CORP	0.74%	1.02M	73.51M	44.03K	+4.52%
Dec 31, 2025	MAGNETAR FINANCIAL LLC	0.84%	1.16M	83.57M	1.16M	+100.00%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.86%	1.18M	85.23M	57.88K	+5.15%
Dec 31, 2025	CITADEL ADVISORS LLC	1.15%	1.59M	114.86M	692.67K	+76.98%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.26%	3.12M	225.14M	262.73K	+9.19%
Dec 31, 2025	ALLIANZ ASSET MANAGEMENT GMBH	0.22%	309.89K	22.35M	295.39K	+2,037.15%
Dec 31, 2025	HARVEST MANAGEMENT LLC	0.24%	329.3K	23.75M	329.3K	+100.00%
Dec 31, 2025	TWIN SECURITIES, INC.	0.26%	365.14K	26.34M	365.14K	+100.00%
Dec 31, 2025	CAPULA MANAGEMENT LTD	0.28%	389.57K	28.1M	389.57K	+100.00%
Dec 31, 2025	SLOTNIK CAPITAL, LLC	0.52%	715K	51.57M	715K	+100.00%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.3%	417.54K	30.12M	35.71K	+9.35%
Dec 31, 2025	PICTON MAHONEY ASSET MANAGEMENT	0.3%	414.4K	29.89M	414.4K	+100.00%
Dec 31, 2025	CAXTON ASSOCIATES LLP	0.32%	442.31K	31.9M	442.31K	+100.00%
Dec 31, 2025	ALETHEA CAPITAL MANAGEMENT, LLC	0.32%	446.13K	32.18M	0	0
Dec 31, 2025	CITIGROUP INC	0.34%	467.69K	33.73M	438.36K	+1,494.73%
Dec 31, 2025	WESTFIELD CAPITAL MANAGEMENT CO LP	0.34%	471.13K	33.98M	471.13K	+100.00%
Dec 31, 2025	CRCM LP	0.15%	202.37K	14.6M	202.37K	+100.00%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.15%	210.6K	15.19M	-96.79K	-31.49%
Dec 31, 2025	MARSHALL WACE, LLP	0.15%	212.58K	15.33M	-427K	-66.76%
Dec 31, 2025	SWISS NATIONAL BANK	0.16%	215.8K	15.57M	7K	+3.35%
Dec 31, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.16%	218.23K	15.74M	188.23K	+627.42%
Dec 31, 2025	NUVEEN, LLC	0.18%	251.46K	18.14M	39.17K	+18.45%
Dec 31, 2025	SOFINNOVA INVESTMENTS, INC.	0.54%	745.12K	53.75M	-130.81K	-14.93%
Dec 31, 2025	ALPINE ASSOCIATES MANAGEMENT INC.	0.63%	867.53K	62.57M	867.53K	+100.00%
Dec 31, 2025	UBS GROUP AG	1.71%	2.36M	170M	1.04M	+79.11%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	2.74%	3.78M	272.42M	2.04M	+118.00%
Dec 31, 2025	STATE STREET CORP	2.97%	4.1M	295.58M	-790.75K	-16.18%
Dec 31, 2025	KRYGER CAPITAL LTD	0.76%	1.05M	75.4M	1.05M	+100.00%
Dec 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.8%	1.11M	79.76M	1.11M	+100.00%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	7.55%	9.79M	426.44M	-1.02M	-9.45%
Sep 30, 2025	SIREN, L.L.C.	0.99%	1.29M	56.01M	175K	+15.76%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.87%	1.12M	48.96M	75.56K	+7.21%
Sep 30, 2025	SOFINNOVA INVESTMENTS, INC.	0.68%	875.93K	38.16M	291.12K	+49.78%
Sep 30, 2025	MARSHALL WACE, LLP	0.49%	639.58K	27.87M	579.36K	+962.03%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.93%	1.2M	52.28M	-327K	-21.41%
Sep 30, 2025	ECOR1 CAPITAL, LLC	0.59%	765K	33.33M	265K	+53.00%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.35%	457.17K	19.92M	52.78K	+13.05%
Sep 30, 2025	FIERA CAPITAL CORP	0.93%	1.2M	52.39M	420.48K	+53.78%
Sep 30, 2025	JPMORGAN CHASE & CO	0.69%	899.56K	39.19M	319.28K	+55.02%
Sep 30, 2025	BIOIMPACT CAPITAL LLC	0.59%	760.02K	33.11M	0	0
Sep 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.31%	406.03K	17.31M	62.31K	+18.13%
Sep 30, 2025	BRAIDWELL LP	0.26%	331.91K	14.46M	331.91K	+100.00%
Sep 30, 2025	WOODLINE PARTNERS LP	0.25%	323.77K	14.11M	-311.32K	-49.02%
Sep 30, 2025	ROYAL BANK OF CANADA	0.24%	316.46K	13.79M	-290.25K	-47.84%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.24%	307.39K	13.39M	51.8K	+20.26%
Sep 30, 2025	MORGAN STANLEY	0.53%	691.51K	30.13M	245.63K	+55.09%
Sep 30, 2025	CANDRIAM S.C.A.	0.38%	487.92K	21.26M	45.14K	+10.20%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	1.33%	1.73M	75.17M	-114.13K	-6.21%
Sep 30, 2025	ORBIMED ADVISORS LLC	1.26%	1.64M	71.41M	-174K	-9.60%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.3%	392.64K	17.11M	120.37K	+44.21%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.3%	385.49K	16.79M	54.93K	+16.62%
Sep 30, 2025	NORTHERN TRUST CORP	0.75%	975.06K	42.48M	-22K	-2.21%
Sep 30, 2025	CITADEL ADVISORS LLC	0.69%	899.76K	39.2M	878.04K	+4,042.18%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.32%	414.2K	18.05M	340.7K	+463.54%
Sep 30, 2025	ABRDN PLC	0.24%	304.83K	13.28M	25K	+8.93%
Sep 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.22%	291.05K	12.68M	243.58K	+513.14%
Sep 30, 2025	DEUTSCHE BANK AG\	0.2%	264.61K	11.53M	23.61K	+9.80%
Sep 30, 2025	NUVEEN, LLC	0.16%	212.29K	9.25M	-57.12K	-21.20%
Sep 30, 2025	SWISS NATIONAL BANK	0.16%	208.8K	9.1M	36.6K	+21.25%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.16%	205.46K	8.95M	203.7K	+11,560.84%
Sep 30, 2025	INVESCO LTD.	0.15%	188.36K	8.21M	-54.7K	-22.50%
Sep 30, 2025	ENVESTNET ASSET MANAGEMENT INC	0.14%	179.1K	7.8M	113.55K	+173.20%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.13%	173.48K	7.56M	46.6K	+36.73%
Sep 30, 2025	NEUBERGER BERMAN GROUP LLC	0.12%	161.44K	7.03M	161.44K	+100.00%
Sep 30, 2025	RHUMBLINE ADVISERS	0.12%	158.07K	6.89M	-17.29K	-9.86%
Sep 30, 2025	EFG ASSET MANAGEMENT (NORTH AMERICA) CORP.	0.12%	149.15K	6.5M	-20.38K	-12.02%
Sep 30, 2025	MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	0.11%	148.85K	6.49M	-26.78K	-15.25%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.09%	121.81K	5.31M	18.69K	+18.12%
Sep 30, 2025	PRUDENTIAL FINANCIAL INC	0.07%	84.87K	3.7M	-28.14K	-24.90%
Sep 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.06%	80.07K	3.49M	-1.29K	-1.58%
Sep 30, 2025	SEI INVESTMENTS CO	0.06%	73.36K	3.2M	17.68K	+31.76%
Sep 30, 2025	ALPS ADVISORS INC	0.05%	70.57K	3.07M	5.55K	+8.53%
Sep 30, 2025	MIRADOR CAPITAL PARTNERS LP	0.05%	64.06K	2.79M	22.67K	+54.76%
Sep 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.05%	60K	1.59M	0	0
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.05%	59.28K	2.58M	-8.87K	-13.02%
Sep 30, 2025	RK CAPITAL MANAGEMENT, LLC/FL	0.05%	58.6K	2.55M	58.6K	+100.00%
Sep 30, 2025	PRIVIUM FUND MANAGEMENT B.V.	0.04%	53K	2.31M	7K	+15.22%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.04%	52.95K	2.31M	-2.99K	-5.34%
Sep 30, 2025	HEALTHINVEST PARTNERS AB	0.04%	51.98K	240.43K	51.98K	+100.00%
Sep 30, 2025	ASSETMARK, INC	0.04%	51.19K	2.23M	21.51K	+72.47%
Sep 30, 2025	MONASHEE INVESTMENT MANAGEMENT LLC	0.04%	50K	2.18M	50K	+100.00%
Sep 30, 2025	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	1.08%	1.4M	61.08M	588K	+72.24%
Sep 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.03%	1.34M	58.23M	370.49K	+38.29%
Sep 30, 2025	ARTISAN PARTNERS LIMITED PARTNERSHIP	0.7%	903.29K	39.36M	21.34K	+2.42%
Sep 30, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.65%	844.63K	36.8M	434.63K	+106.01%
Sep 30, 2025	SUVRETTA CAPITAL MANAGEMENT, LLC	0.58%	750K	32.68M	750K	+100.00%
Sep 30, 2025	CLEARBRIDGE INVESTMENTS, LLC	0.57%	741.69K	32.32M	741.69K	+100.00%
Sep 30, 2025	BAKER BROS. ADVISORS LP	0.48%	625K	27.23M	625K	+100.00%
Sep 30, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	0.48%	625K	27.23M	0	0
Sep 30, 2025	LOGOS GLOBAL MANAGEMENT LP	0.46%	600K	26.14M	-350K	-36.84%
Sep 30, 2025	ENSIGN PEAK ADVISORS, INC	0.45%	580.86K	25.31M	50.04K	+9.43%
Sep 30, 2025	ALETHEA CAPITAL MANAGEMENT, LLC	0.34%	446.13K	19.44M	17.5K	+4.08%
Sep 30, 2025	FMR LLC	16.65%	21.59M	940.5M	5.4M	+33.36%
Sep 30, 2025	VANGUARD GROUP INC	10.2%	13.22M	575.98M	3.97M	+42.94%
Sep 30, 2025	BELLEVUE GROUP AG	1.66%	2.15M	93.8M	2.15M	+100.00%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.29%	381.83K	16.64M	-1.33K	-0.35%
Sep 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	0.29%	375.99K	16.38M	65	+0.02%
Sep 30, 2025	BARCLAYS PLC	0.27%	352.29K	15.35M	-19.48K	-5.24%
Sep 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.27%	343.55K	14.97M	-5.63K	-1.61%
Sep 30, 2025	JANUS HENDERSON GROUP PLC	11.2%	14.52M	632.81M	3.75M	+34.75%
Sep 30, 2025	RTW INVESTMENTS, LP	8.77%	11.37M	495.51M	1.75M	+18.23%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	7.77%	10.07M	438.54M	815.5K	+8.82%
Sep 30, 2025	BLACKROCK, INC.	7.1%	9.2M	400.96M	-134.26K	-1.44%
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	6.67%	8.64M	376.49M	1.38M	+18.92%
Sep 30, 2025	AVORO CAPITAL ADVISORS LLC	5.9%	7.65M	333.09M	595K	+8.44%
Sep 30, 2025	STATE STREET CORP	3.77%	4.89M	213M	687.12K	+16.35%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.2%	2.86M	124.55M	10.08K	+0.35%
Sep 30, 2025	POLAR CAPITAL HOLDINGS PLC	2.16%	2.8M	121.85M	1.03M	+57.97%
Sep 30, 2025	CASDIN CAPITAL, LLC	1.37%	1.78M	77.55M	5K	+0.28%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.34%	1.73M	75.48M	586.94K	+51.24%
Sep 30, 2025	UBS GROUP AG	1.02%	1.32M	57.33M	719.31K	+120.58%
Jun 30, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.06%	75K	2.13M	75K	+100.00%
Jun 30, 2025	ALPS ADVISORS INC	0.05%	65.02K	1.85M	-22.34K	-25.57%
Jun 30, 2025	STATE OF WISCONSIN INVESTMENT BOARD	0.05%	65.02K	1.85M	6.33K	+10.78%
Jun 30, 2025	CASDIN CAPITAL, LLC	1.37%	1.78M	50.41M	-270K	-13.20%
Jun 30, 2025	POLAR CAPITAL HOLDINGS PLC	1.37%	1.77M	50.28M	-18.48K	-1.03%
Jun 30, 2025	LOGOS GLOBAL MANAGEMENT LP	0.73%	950K	26.98M	600K	+171.43%
Jun 30, 2025	CITIGROUP INC	0.22%	289.85K	8.23M	-87.43K	-23.17%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.81%	1.05M	29.77M	24.64K	+2.41%
Jun 30, 2025	NORTHERN TRUST CORP	0.77%	997.06K	28.32M	-21.43K	-2.10%
Jun 30, 2025	WOODLINE PARTNERS LP	0.49%	635.09K	18.04M	-230.83K	-26.66%
Jun 30, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	0.48%	625K	17.75M	100K	+19.05%
Jun 30, 2025	UBS GROUP AG	0.46%	596.55K	16.94M	-1.44K	-0.24%
Jun 30, 2025	JPMORGAN CHASE & CO	0.45%	580.28K	16.48M	139.47K	+31.64%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.18%	1.53M	43.37M	-618.88K	-28.84%
Jun 30, 2025	SIREN, L.L.C.	0.86%	1.11M	31.54M	0	0
Jun 30, 2025	TD ASSET MANAGEMENT INC	0.31%	404.4K	11.48M	-28.75K	-6.64%
Jun 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.31%	395.97K	11.25M	38.25K	+10.69%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.3%	383.16K	10.88M	16.57K	+4.52%
Jun 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	0.29%	375.92K	10.68M	0	0
Jun 30, 2025	BARCLAYS PLC	0.29%	371.77K	10.56M	47.88K	+14.78%
Jun 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.27%	349.18K	9.92M	17K	+5.12%
Jun 30, 2025	ENSIGN PEAK ADVISORS, INC	0.41%	530.81K	15.08M	200.84K	+60.86%
Jun 30, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.32%	410K	11.64M	-1.31K	-0.32%
Jun 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.27%	343.72K	9.76M	234.72K	+215.33%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.26%	330.56K	9.39M	180.48K	+120.25%
Jun 30, 2025	ABRDN PLC	0.22%	279.83K	7.95M	0	0
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	7.14%	9.25M	262.69M	-434.87K	-4.49%
Jun 30, 2025	JANUS HENDERSON GROUP PLC	8.31%	10.78M	306.06M	-649.38K	-5.68%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	8.34%	10.81M	306.97M	-529.37K	-4.67%
Jun 30, 2025	BIOIMPACT CAPITAL LLC	0.59%	760.02K	21.58M	45.8K	+6.41%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.88%	1.15M	32.53M	360.83K	+45.98%
Jun 30, 2025	FIERA CAPITAL CORP	0.6%	781.91K	22.21M	9.61K	+1.24%
Jun 30, 2025	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	0.63%	813.91K	23.12M	42.75K	+5.54%
Jun 30, 2025	ARTISAN PARTNERS LIMITED PARTNERSHIP	0.68%	881.95K	25.05M	-46.27K	-4.99%
Jun 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.75%	967.6K	27.48M	94.38K	+10.81%
Jun 30, 2025	NORGES BANK	0.77%	995.12K	28.26M	995.12K	+100.00%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	1.42%	1.84M	52.24M	264.83K	+16.82%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.2%	2.85M	80.89M	92.72K	+3.37%
Jun 30, 2025	STATE STREET CORP	3.24%	4.2M	119.32M	-119.85K	-2.77%
Jun 30, 2025	VANGUARD GROUP INC	7.13%	9.25M	262.65M	5.1K	+0.06%
Jun 30, 2025	ROYAL BANK OF CANADA	0.47%	606.71K	17.23M	562.4K	+1,269.42%
Jun 30, 2025	SOFINNOVA INVESTMENTS, INC.	0.45%	584.8K	16.61M	204.87K	+53.92%
Jun 30, 2025	ECOR1 CAPITAL, LLC	0.39%	500K	14.2M	-57.58K	-10.33%
Jun 30, 2025	MORGAN STANLEY	0.34%	445.88K	12.66M	-79.82K	-15.18%
Jun 30, 2025	CANDRIAM S.C.A.	0.34%	442.77K	12.58M	3.67K	+0.84%
Jun 30, 2025	ALETHEA CAPITAL MANAGEMENT, LLC	0.33%	428.62K	12.17M	6.9K	+1.64%
Jun 30, 2025	FMR LLC	12.49%	16.19M	459.68M	570.73K	+3.66%
Jun 30, 2025	RTW INVESTMENTS, LP	7.42%	9.62M	273.18M	871.92K	+9.97%
Jun 30, 2025	BLACKROCK, INC.	7.2%	9.34M	265.17M	-580.64K	-5.85%
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	5.61%	7.27M	206.36M	965.62K	+15.33%
Jun 30, 2025	AVORO CAPITAL ADVISORS LLC	5.44%	7.05M	200.22M	-575K	-7.54%
Jun 30, 2025	TORONTO DOMINION BANK	2.73%	3.53M	100.33M	3.53M	+100.00%
Jun 30, 2025	ORBIMED ADVISORS LLC	1.4%	1.81M	51.49M	0	0
Jun 30, 2025		0.06%	81.36K	2.31M	-103.79K	-56.06%
Jun 30, 2025	D. E. SHAW & CO., INC.	0.18%	237.4K	6.74B	237.4K	+100.00%
Jun 30, 2025	CORMORANT ASSET MANAGEMENT, LP	0.15%	200K	5.68M	-200K	-50.00%
Jun 30, 2025	MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	0.14%	175.63K	4.99M	10.81K	+6.56%
Jun 30, 2025	EFG ASSET MANAGEMENT (NORTH AMERICA) CORP.	0.13%	169.53K	4.81M	14.11K	+9.08%
Jun 30, 2025	CAPTION MANAGEMENT, LLC	0.13%	162K	4.6M	95.7K	+144.34%
Jun 30, 2025	RAYMOND JAMES FINANCIAL INC	0.12%	151.24K	4.3M	-8.03K	-5.04%
Jun 30, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0.11%	137.31K	3.9M	-6.5K	-4.52%
Jun 30, 2025	ALLY BRIDGE GROUP (NY) LLC	0.1%	132.74K	3.77M	132.74K	+100.00%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.1%	130.83K	3.72B	3.06K	+2.39%
Jun 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.1%	126.88K	3.6M	-17.94K	-12.38%
Jun 30, 2025	SPHERA FUNDS MANAGEMENT LTD.	0.1%	126K	3.58M	20K	+18.87%
Jun 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.1%	125K	3.55M	25K	+25.00%
Jun 30, 2025	PALO ALTO INVESTORS LP	0.09%	118.89K	3.38M	118.89K	+100.00%
Jun 30, 2025	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0.07%	90.26K	2.56B	466	+0.52%
Mar 31, 2025	CORMORANT ASSET MANAGEMENT, LP	0.31%	400K	11.81M	-650K	-61.90%
Mar 31, 2025	AVORO CAPITAL ADVISORS LLC	5.9%	7.63M	225.09M	125K	+1.67%
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	4.88%	6.3M	185.99M	0	0
Mar 31, 2025	STATE STREET CORP	3.34%	4.32M	127.57M	-280.83K	-6.10%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.13%	2.76M	81.35M	-52.21K	-1.86%
Mar 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.66%	2.15M	63.35M	-606.06K	-22.02%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	1.22%	1.57M	46.48M	1.4M	+781.63%
Mar 31, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	0.41%	525K	15.5M	525K	+100.00%
Mar 31, 2025	JPMORGAN CHASE & CO	0.34%	440.8K	13.01M	-9.34K	-2.08%
Mar 31, 2025	CANDRIAM S.C.A.	0.34%	439.1K	12.96M	78.39K	+21.73%
Mar 31, 2025	TD ASSET MANAGEMENT INC	0.34%	433.14K	12.79M	17.97K	+4.33%
Mar 31, 2025	FINEPOINT CAPITAL LP	0.29%	380.7K	11.24M	-10.6K	-2.71%
Mar 31, 2025	FMR LLC	12.08%	15.62M	460.96M	-894.54K	-5.42%
Mar 31, 2025	ORBIMED ADVISORS LLC	1.4%	1.81M	53.52M	700K	+62.90%
Mar 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.98%	1.27M	37.52M	42.87K	+3.49%
Mar 31, 2025	SIREN, L.L.C.	0.86%	1.11M	32.79M	-16.69K	-1.48%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.79%	1.02M	30.22M	-5.35K	-0.52%
Mar 31, 2025	NORTHERN TRUST CORP	0.79%	1.02M	30.07M	-60.95K	-5.65%
Mar 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.68%	873.22K	25.78M	74.19K	+9.29%
Mar 31, 2025	WOODLINE PARTNERS LP	0.67%	865.93K	25.56M	105	+0.01%
Mar 31, 2025	FIERA CAPITAL CORP	0.6%	772.3K	22.8M	371.12K	+92.51%
Mar 31, 2025		0.33%	431.21K	12.73M	431.21K	+100.00%
Mar 31, 2025	ALETHEA CAPITAL MANAGEMENT, LLC	0.33%	421.72K	12.45M	853	+0.20%
Mar 31, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.32%	411.31K	12.14M	-132.34K	-24.34%
Mar 31, 2025	SOFINNOVA INVESTMENTS, INC.	0.29%	379.93K	11.22M	366.14K	+2,655.32%
Mar 31, 2025	CITIGROUP INC	0.29%	377.28K	11.14M	187.33K	+98.62%
Mar 31, 2025	IKARIAN CAPITAL, LLC	0.23%	300K	8.86M	-100K	-25.00%
Mar 31, 2025	INVESCO LTD.	0.22%	288.14K	8.51M	193.38K	+204.06%
Mar 31, 2025	ABRDN PLC	0.22%	279.83K	8.26M	234.92K	+523.06%
Mar 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.28%	357.72K	10.56M	25.33K	+7.62%
Mar 31, 2025	JANUS HENDERSON GROUP PLC	8.84%	11.43M	361.13M	4.37M	+62.01%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	8.77%	11.34M	334.7M	295.28K	+2.67%
Mar 31, 2025	VANGUARD GROUP INC	7.15%	9.24M	272.86M	-188.71K	-2.00%
Mar 31, 2025	CASDIN CAPITAL, LLC	1.58%	2.05M	60.37M	0	0
Mar 31, 2025	ARTISAN PARTNERS LIMITED PARTNERSHIP	0.72%	928.23K	27.4M	-87.02K	-8.57%
Mar 31, 2025	MARSHALL WACE, LLP	0.35%	455.2K	13.44M	292.33K	+179.50%
Mar 31, 2025	RTW INVESTMENTS, LP	6.77%	8.75M	258.21M	814.06K	+10.26%
Mar 31, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.26%	332.18K	9.81M	-14.01K	-4.05%
Mar 31, 2025	POLAR CAPITAL HOLDINGS PLC	1.38%	1.79M	52.81M	516.98K	+40.65%
Mar 31, 2025	BLACKROCK, INC.	7.67%	9.92M	292.76M	-14.9K	-0.15%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.61%	784.7K	23.16M	21.65K	+2.84%
Mar 31, 2025	BARCLAYS PLC	0.25%	323.9K	9.56M	73.88K	+29.55%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	7.49%	9.68M	285.89M	1.58M	+19.47%
Mar 31, 2025	UBS GROUP AG	0.46%	598K	17.65M	392.09K	+190.42%
Mar 31, 2025	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	0.6%	771.16K	22.77M	771.16K	+100.00%
Mar 31, 2025	EVENTIDE ASSET MANAGEMENT, LLC	0.29%	375.92K	11.1M	0	0
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.28%	366.59K	10.82M	3.58K	+0.99%
Mar 31, 2025	ENSIGN PEAK ADVISORS, INC	0.26%	329.98K	9.74M	302.03K	+1,080.60%
Mar 31, 2025	MORGAN STANLEY	0.41%	525.7K	15.52M	-688.08K	-56.69%
Mar 31, 2025	BIOIMPACT CAPITAL LLC	0.55%	714.22K	21.08M	11.24K	+1.60%
Mar 31, 2024	DEUTSCHE BANK AG\	0.18%	134.75K	3.44M	-628.1K	-82.34%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.75%	548.44K	14M	2.66K	+0.49%
Mar 31, 2024	WOODLINE PARTNERS LP	0.8%	586.34K	14.96M	528.22K	+908.82%
Mar 31, 2024	FARALLON CAPITAL MANAGEMENT LLC	0.83%	606.06K	15.47M	606.06K	+100.00%
Mar 31, 2024	5AM VENTURE MANAGEMENT, LLC	0.91%	665.56K	16.98M	0	0
Mar 31, 2024	NORTHERN TRUST CORP	0.92%	671.33K	17.13M	8.46K	+1.28%
Mar 31, 2024	JPMORGAN CHASE & CO	1.22%	893.47K	22.8M	-74.43K	-7.69%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	1.38%	1.01M	25.78M	-489.61K	-32.65%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	1.47%	1.07M	27.4M	583.27K	+118.89%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	2.19%	1.6M	40.83M	52.46K	+3.39%
Mar 31, 2024	MIRADOR CAPITAL PARTNERS LP	0.06%	47.07K	1.2M	-5.49K	-10.44%
Mar 31, 2024	HARBOR CAPITAL ADVISORS, INC.	0.05%	40.07K	1.02M	7.72K	+23.86%
Mar 31, 2024	MITSUBISHI UFJ KOKUSAI ASSET MANAGEMENT CO., LTD.	0.05%	39.36K	1M	-1.8K	-4.38%
Mar 31, 2024	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.05%	37.46K	798.43K	-128.56K	-77.44%
Mar 31, 2024	METLIFE INVESTMENT MANAGEMENT, LLC	0.05%	37.33K	952.74K	0	0
Mar 31, 2024	SEI INVESTMENTS CO	0.05%	36.64K	934.93M	4.88K	+15.37%
Mar 31, 2024	AMERICAN INTERNATIONAL GROUP, INC.	0.05%	36.46K	930.33K	-312	-0.85%
Mar 31, 2024	TWO SIGMA ADVISERS, LP	0.62%	453.9K	11.58M	-50.2K	-9.96%
Mar 31, 2024	BLACKROCK INC.	8.45%	6.17M	157.36M	-330.6K	-5.09%
Mar 31, 2024	COWEN AND COMPANY, LLC	7.71%	5.63M	143.65M	0	0
Mar 31, 2024	RA CAPITAL MANAGEMENT, L.P.	4.5%	3.28M	83.76M	827.65K	+33.72%
Mar 31, 2024	ADAGE CAPITAL PARTNERS GP, L.L.C.	3.29%	2.4M	61.25M	800.05K	+50.00%
Mar 31, 2024	CASDIN CAPITAL, LLC	2.86%	2.08M	53.21M	909.09K	+77.32%
Mar 31, 2024	BOXER CAPITAL, LLC	2.37%	1.73M	44.08M	606.06K	+54.05%
Mar 31, 2024	MORGAN STANLEY	2.11%	1.54M	39.23M	46.55K	+3.12%
Mar 31, 2024	JANUS HENDERSON GROUP PLC	1.7%	1.24M	31.7M	1.22M	+4,661.27%
Mar 31, 2024	WELLINGTON MANAGEMENT GROUP LLP	1.68%	1.23M	31.36M	937.78K	+322.02%
Mar 31, 2024	ORBIMED ADVISORS LLC	1.36%	994.1K	25.37M	994.1K	+100.00%
Mar 31, 2024	ALETHEA CAPITAL MANAGEMENT, LLC	1.04%	760.7K	19.41M	-93.95K	-10.99%
Mar 31, 2024	ECOR1 CAPITAL, LLC	1.04%	757.58K	19.33M	757.58K	+100.00%
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	0.37%	267.13K	6.82M	-3.03K	-1.12%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.34%	248.28K	6.34M	-10.37K	-4.01%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.34%	247.3K	6.31M	-420.23K	-62.95%
Mar 31, 2024	CITIGROUP INC	0.32%	235.87K	6.02M	150.26K	+175.54%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.32%	230.13K	5.87M	71.52K	+45.09%
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.29%	213.28K	5.44M	-54.45K	-20.34%
Mar 31, 2024	UBS GROUP AG	0.27%	195.45K	4.99M	1.1K	+0.56%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.25%	181.67K	4.64M	-78.94K	-30.29%
Mar 31, 2024	PROPEL BIO MANAGEMENT, LLC	0.24%	178.5K	4.56M	0	0
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	0.23%	168.59K	4.3M	-172.03K	-50.50%
Mar 31, 2024	NEW YORK STATE COMMON RETIREMENT FUND	0.17%	121.23K	3.09M	16.23K	+15.45%
Mar 31, 2024	SIMPLIFY ASSET MANAGEMENT INC.	0.17%	125K	3.19M	0	0
Mar 31, 2024	ABRDN PLC	0.18%	129.41K	3.3M	0	0
Mar 31, 2024	RTW INVESTMENTS, LP	10.92%	7.97M	203.4M	1.28M	+19.14%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.71%	515.28K	13.15M	161.64K	+45.71%
Mar 31, 2024	EXOME ASSET MANAGEMENT LLC	0.19%	135.17K	3.45M	135.17K	+100.00%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.19%	138.97K	3.55M	121.64K	+701.75%
Mar 31, 2024	SWISS NATIONAL BANK	0.19%	140.8K	3.59M	24K	+20.55%
Mar 31, 2024	MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	0.2%	143.34K	3.66M	-5.87K	-3.93%
Mar 31, 2024	WELLS FARGO & COMPANY/MN	0.22%	157.98K	4.03M	-32.75K	-17.17%
Mar 31, 2024	RAYMOND JAMES & ASSOCIATES	0.41%	295.72K	7.55M	165.8K	+127.61%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.45%	328.53K	8.38M	-46.15K	-12.32%
Mar 31, 2024	INVESCO LTD.	0.51%	373.32K	9.53M	245.44K	+191.95%
Mar 31, 2024	VANGUARD GROUP INC	5.27%	3.85M	98.13M	-198.11K	-4.90%
Mar 31, 2024	AVORO CAPITAL ADVISORS LLC	7.98%	5.83M	148.65M	3.32M	+132.07%
Mar 31, 2024	STATE STREET CORP	4.74%	3.46M	88.35M	23.49K	+0.68%
Mar 31, 2024	ARTISAN PARTNERS LIMITED PARTNERSHIP	3.19%	2.33M	59.37M	223.48K	+10.63%
Mar 31, 2024	PRICE T ROWE ASSOCIATES INC /MD/	10.18%	7.43M	189.59M	516.45K	+7.47%
Mar 31, 2024	FMR LLC	19.51%	14.24M	363.45M	3.84M	+36.88%
Mar 31, 2024	SILVERARC CAPITAL MANAGEMENT, LLC	0.67%	489.3K	12.49M	489.3K	+100.00%
Mar 31, 2024	RAYMOND JAMES FINANCIAL SERVICES ADVISORS, INC.	0.16%	119.58K	3.05M	32.97K	+38.07%
Mar 31, 2024	RHUMBLINE ADVISERS	0.16%	118.88K	3.03M	4.11K	+3.58%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.07%	50.9K	1.3M	50.9K	+100.00%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.1%	76.05K	1.94B	17.21K	+29.26%
Mar 31, 2024	STEMPOINT CAPITAL LP	0.1%	75K	183.75K	75K	+100.00%
Mar 31, 2024	HENNION & WALSH ASSET MANAGEMENT, INC.	0.1%	72.97K	1.86M	1.78K	+2.50%
Mar 31, 2024	CAMPBELL & CO INVESTMENT ADVISER LLC	0.1%	70.7K	1.8M	70.7K	+100.00%
Mar 31, 2024	CREDIT SUISSE AG/	0.09%	66.78K	1.7M	16.45K	+32.68%
Mar 31, 2024	US BANCORP \DE\	0.09%	62.1K	1.58M	140	+0.23%
Mar 31, 2024	DEKABANK DEUTSCHE GIROZENTRALE	0.08%	60K	1.48M	0	0
Mar 31, 2024	LOS ANGELES CAPITAL MANAGEMENT LLC	0.08%	57K	1.45M	-3.29K	-5.46%
Mar 31, 2024	ALPS ADVISORS INC	0.08%	56.23K	1.43M	5.55K	+10.96%
Mar 31, 2024	BALYASNY ASSET MANAGEMENT L.P.	0.07%	51.06K	1.3M	-1.16M	-95.80%
Dec 31, 2023	AARON WEALTH ADVISORS LLC	0.18%	134.24K	1.21M	828	+0.62%
Dec 31, 2023	GSA CAPITAL PARTNERS LLP	0.19%	144.2K	1.31M	-195.48K	-57.55%
Dec 31, 2023	MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	0.2%	149.2K	1.35M	15.25K	+11.38%
Dec 31, 2023	CASDIN CAPITAL, LLC	1.59%	1.18M	10.64M	-74.25K	-5.94%
Dec 31, 2023	BALYASNY ASSET MANAGEMENT L.P.	1.64%	1.22M	11M	-804.05K	-39.81%
Dec 31, 2023	MORGAN STANLEY	2.01%	1.49M	13.49M	333.16K	+28.78%
Dec 31, 2023	BLACKROCK INC.	8.77%	6.5M	58.79M	710.02K	+12.27%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	2.02%	1.5M	13.57M	-91.1K	-5.73%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	2.09%	1.55M	14M	111.66K	+7.78%
Dec 31, 2023	ADAGE CAPITAL PARTNERS GP, L.L.C.	2.16%	1.6M	14.48M	300K	+23.08%
Dec 31, 2023	ARTISAN PARTNERS LIMITED PARTNERSHIP	2.84%	2.1M	19.03M	-50.88K	-2.36%
Dec 31, 2023	RA CAPITAL MANAGEMENT, L.P.	3.31%	2.45M	22.21M	-3.96M	-61.75%
Dec 31, 2023	AVORO CAPITAL ADVISORS LLC	3.39%	2.51M	22.72M	0	0
Dec 31, 2023	STATE STREET CORP	4.64%	3.44M	31.12M	-721.96K	-17.35%
Dec 31, 2023	VANGUARD GROUP INC	5.46%	4.04M	36.59M	28.69K	+0.71%
Dec 31, 2023	COWEN AND COMPANY, LLC	7.6%	5.63M	50.94M	0	0
Dec 31, 2023	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.21%	158.61K	1.44M	16.34K	+11.49%
Dec 31, 2023	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.22%	166.02K	1.5M	124.63K	+301.15%
Dec 31, 2023		0.24%	178.5K	1.62M	178.5K	+100.00%
Dec 31, 2023	WELLS FARGO & COMPANY/MN	0.26%	190.73K	1.73M	-10.4K	-5.17%
Dec 31, 2023	UBS GROUP AG	0.26%	194.35K	1.76M	78.39K	+67.60%
Dec 31, 2023	MARSHALL WACE, LLP	0.27%	197.72K	1.79M	197.72K	+100.00%
Dec 31, 2023	BARCLAYS PLC	0.27%	198.11K	1.79M	8.79K	+4.65%
Dec 31, 2023	RENAISSANCE TECHNOLOGIES LLC	0.31%	226.7K	2.05M	115.9K	+104.60%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.35%	258.65K	2.34M	6.62K	+2.63%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.35%	260.61K	2.36M	-99.61K	-27.65%
Dec 31, 2023	TD ASSET MANAGEMENT INC	0.36%	267.73K	2.42M	0	0
Dec 31, 2023	RAFFERTY ASSET MANAGEMENT, LLC	0.36%	270.16K	2.44M	-118.92K	-30.57%
Dec 31, 2023	CANDRIAM S.C.A.	0.39%	290.07K	2.63M	120K	+70.56%
Dec 31, 2023	WELLINGTON MANAGEMENT GROUP LLP	0.39%	291.22K	2.64M	291.22K	+100.00%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	0.46%	340.62K	3.08M	-399.88K	-54.00%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.48%	353.65K	3.2M	-122.27K	-25.69%
Dec 31, 2023	NORTHERN TRUST CORP	0.89%	662.87K	6M	22.52K	+3.52%
Dec 31, 2023	RTW INVESTMENTS, LP	9.03%	6.69M	60.54M	0	0
Dec 31, 2023	PRICE T ROWE ASSOCIATES INC /MD/	9.33%	6.91M	62.56M	296.24K	+4.48%
Dec 31, 2023	FMR LLC	14.04%	10.4M	94.16M	-710.34K	-6.39%
Dec 31, 2023	RAYMOND JAMES & ASSOCIATES	0.18%	129.92K	1.18M	36.67K	+39.32%
Dec 31, 2023	SCHONFELD STRATEGIC ADVISORS LLC	0.18%	130.12K	1.18M	2.82K	+2.21%
Dec 31, 2023	ALETHEA CAPITAL MANAGEMENT, LLC	1.15%	854.65K	7.73M	0	0
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.66%	490.59K	4.44M	279.72K	+132.65%
Dec 31, 2023	CITADEL ADVISORS LLC	0.67%	493.66K	4.47M	263.31K	+114.31%
Dec 31, 2023	TWO SIGMA ADVISERS, LP	0.68%	504.1K	4.56M	-35.3K	-6.54%
Dec 31, 2023	LOGOS GLOBAL MANAGEMENT LP	1.05%	775K	7.01M	775K	+100.00%
Dec 31, 2023	DEUTSCHE BANK AG\	1.03%	762.85K	6.9M	628.3K	+466.96%
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	0.9%	667.53K	6.04M	104.19K	+18.50%
Dec 31, 2023	BOXER CAPITAL, LLC	1.51%	1.12M	10.15M	0	0
Dec 31, 2023	JPMORGAN CHASE & CO	1.31%	967.9K	8.76M	-2.8K	-0.29%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.74%	545.77K	4.94M	30.67K	+5.96%
Dec 31, 2023	ALLIANCEBERNSTEIN L.P.	0.51%	374.68K	3.39M	-152.94K	-28.99%
Dec 31, 2023	5AM VENTURE MANAGEMENT, LLC	0.9%	665.56K	6.02M	0	0

Insiders

Among the RNA insiders holding of 4.79% of the stake in company, RTW INVESTMENTS, LP, 10 percent owner, holds the largest shares of 4.8M. CORMORANT ASSET MANAGEMENT, LP, , is the second largest RNA insider with ownership of 2.51M shares. BOYCE SARAH, President and CEO, stands third with possession of 269.01K shares of that stake.

Insiders	Designation	Shares Held
RTW INVESTMENTS, LP	10 percent owner	4.8M
CORMORANT ASSET MANAGEMENT, LP		2.51M
BOYCE SARAH	President and CEO	269.01K
MCCARTHY TERESA	Chief Human Resources Officer	113.94K
FLANAGAN W. MICHAEL	Chief Scientific Officer	85.09K
MORIARTY JOHN B	Chief Legal Officer	74.56K
MACLEAN MICHAEL F	Chief Financial Officer	59.29K
MOSBROOKER ERIC	Chief Commercial Officer	55K
WILSON TROY EDWARD	director	54.43K
GALLAGHER KATHLEEN P.	Chief Program Officer	50.2K
CALDERARO CHARLES III	Chief Technical Officer	49.8K
HUGHES STEVEN GEORGE	Chief Medical Officer	31.6K
LEVIN ARTHUR A	director	16.56K
THOMPSON TAMAR	director	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Jan 21, 2026	MCCARTHY TERESA	SALE	72.45	1.45K	105.27K	113.94K
Jan 21, 2026	LEVIN ARTHUR A	SALE	72.45	1.76K	127.37K	16.56K
Jan 21, 2026	HUGHES STEVEN GEORGE	SALE	72.45	2.88K	208.51K	31.6K
Jan 21, 2026	FLANAGAN W. MICHAEL	SALE	72.45	2.56K	185.33K	85.09K
Jan 21, 2026	BOYCE SARAH	SALE	72.45	7.99K	579.09K	269.01K
Jan 21, 2026	MACLEAN MICHAEL F	SALE	72.45	2.74K	198.15K	59.29K
Jan 07, 2026	MACLEAN MICHAEL F	SALE	72.23	1.97K	142.58K	63.83K
Jan 07, 2026	MORIARTY JOHN B	SALE	72.23	2.37K	171.47K	74.56K
Jan 07, 2026	MCCARTHY TERESA	SALE	72.23	1.97K	141.93K	116.87K
Jan 07, 2026	CALDERARO CHARLES III	SALE	72.23	3.73K	269.2K	49.8K
Jan 07, 2026	BOYCE SARAH	SALE	72.23	8.58K	619.44K	283.39K
Jan 07, 2026	FLANAGAN W. MICHAEL	SALE	72.23	2.37K	171.4K	91.63K
Jan 07, 2026	HUGHES STEVEN GEORGE	SALE	72.23	2.37K	171.4K	36.49K
Oct 22, 2025	HUGHES STEVEN GEORGE	SALE	47.54	2.21K	105.01K	38.87K
Oct 15, 2025	MCCARTHY TERESA	SALE	50.15	20K	1M	97.13K
Oct 03, 2025	MOSBROOKER ERIC	SALE	45.38	6.56K	297.77K	55K
Sep 22, 2025	HUGHES STEVEN GEORGE	SALE	40.58	2.21K	89.6K	38.87K
Sep 15, 2025	HUGHES STEVEN GEORGE	SALE	45.41	1.54K	70.02K	38.87K
Sep 15, 2025	MCCARTHY TERESA	SALE	41.41	15K	621.14K	97.13K
Sep 11, 2025	FLANAGAN W. MICHAEL	SALE	38.94	20K	778.7K	80.2K
Sep 05, 2025	BOYCE SARAH	SALE	49.95	50K	2.5M	305.87K
Sep 05, 2025	WILSON TROY EDWARD	SALE	50.00	15K	750K	54.43K
Sep 03, 2025	MOSBROOKER ERIC	SALE	47.07	6.56K	308.94K	55K
Sep 02, 2025	GALLAGHER KATHLEEN P.	SALE	47.42	188	8.91K	50.2K
Aug 28, 2025	BOYCE SARAH	SALE	49.39	25K	1.23M	305.87K
Aug 22, 2025	HUGHES STEVEN GEORGE	SALE	46.40	2.21K	102.46K	38.87K
Aug 15, 2025	MCCARTHY TERESA	SALE	46.56	10K	465.63K	97.13K
Aug 13, 2025	HUGHES STEVEN GEORGE	SALE	46.66	1.54K	71.95K	38.87K
Aug 06, 2025	WILSON TROY EDWARD	SALE	45.00	17.78K	799.97K	17.78K
Aug 06, 2025	LEVIN ARTHUR A	SALE	47.62	107.5K	5.12M	19.65K
Aug 06, 2025	MOSBROOKER ERIC	SALE	44.06	6.12K	269.66K	55K
Aug 06, 2025	MACLEAN MICHAEL F	SALE	42.73	30.91K	1.32M	65.81K
Aug 06, 2025	HUGHES STEVEN GEORGE	SALE	42.74	33.98K	1.45M	38.87K
Aug 04, 2025	MORIARTY JOHN B	SALE	36.21	2.25K	81.29K	47.76K
Jun 17, 2025	GALLAGHER KATHLEEN P.	SALE	30.24	911	27.55K	50.39K
Jun 11, 2025	FLANAGAN W. MICHAEL	SALE	32.88	20K	657.69K	80.2K
Jun 02, 2025	GALLAGHER KATHLEEN P.	SALE	32.48	5.88K	190.83K	50.55K
May 01, 2025	GALLAGHER KATHLEEN P.	SALE	32.40	5.88K	190.32K	50.55K
Apr 01, 2025	GALLAGHER KATHLEEN P.	SALE	27.83	329	9.16K	50.55K
Mar 20, 2025	MCCARTHY TERESA	SALE	31.06	7.78K	241.58K	97.13K
Mar 20, 2025	MACLEAN MICHAEL F	SALE	31.06	7.94K	246.42K	96.72K
Mar 20, 2025	BOYCE SARAH	SALE	31.06	31.54K	979.56K	305.87K
Mar 20, 2025	HUGHES STEVEN GEORGE	SALE	31.06	9.58K	297.49K	72.85K
Mar 20, 2025	FLANAGAN W. MICHAEL	SALE	31.06	11.78K	365.87K	80.2K
Mar 11, 2025	FLANAGAN W. MICHAEL	SALE	30.13	20K	602.61K	91.98K
Mar 03, 2025	GALLAGHER KATHLEEN P.	SALE	29.41	5.88K	172.81K	50.55K
Feb 03, 2025	GALLAGHER KATHLEEN P.	SALE	32.16	5.88K	188.92K	50.55K
Jan 22, 2025	GALLAGHER KATHLEEN P.	SALE	30.16	5.63K	169.78K	50.55K
Jan 21, 2025	LEVIN ARTHUR A	SALE	28.60	1.87K	53.54K	12.96K
Jan 21, 2025	HUGHES STEVEN GEORGE	SALE	28.59	2.03K	58.1K	82.43K
Jan 21, 2025	MACLEAN MICHAEL F	SALE	28.59	1.67K	47.61K	104.66K
Jan 21, 2025	MCCARTHY TERESA	SALE	28.60	1.22K	34.92K	104.91K
Jan 21, 2025	FLANAGAN W. MICHAEL	SALE	28.59	1.81K	51.81K	91.98K
Jan 21, 2025	GALLAGHER KATHLEEN P.	SALE	28.59	1.82K	51.95K	56.18K
Jan 21, 2025	BOYCE SARAH	SALE	28.59	5.66K	161.82K	337.41K
Dec 18, 2024	FLANAGAN W. MICHAEL	SALE	32.66	12.74K	416.15K	72.65K
Dec 18, 2024	MACLEAN MICHAEL F	SALE	32.66	11.15K	364.19K	82.94K
Dec 18, 2024	BOYCE SARAH	SALE	32.66	31.86K	1.04M	265.31K
Dec 18, 2024	MCCARTHY TERESA	SALE	32.66	11.15K	364.19K	82.87K
Dec 16, 2024	MCCARTHY TERESA	SALE	33.26	25K	831.61K	94.02K
Dec 11, 2024	FLANAGAN W. MICHAEL	SALE	35.77	24K	858.4K	85.39K
Nov 19, 2024	LEVIN ARTHUR A	SALE	42.12	3.32K	139.97K	14.83K
Nov 18, 2024	MCCARTHY TERESA	SALE	41.14	25K	1.03M	94.02K
Nov 06, 2024	MACLEAN MICHAEL F	SALE	45.33	13.88K	629.01K	94.09K
Oct 21, 2024	LEVIN ARTHUR A	SALE	46.63	5K	233.17K	14.83K
Oct 16, 2024	MCCARTHY TERESA	SALE	48.52	25K	1.21M	94.02K
Oct 07, 2024	THOMPSON TAMAR	SALE	44.98	30K	1.35M	0
Oct 01, 2024	FLANAGAN W. MICHAEL	SALE	47.62	62.5K	2.98M	85.39K
Sep 23, 2024	MACLEAN MICHAEL F	SALE	44.00	11.51K	506.44K	96.36K
Sep 23, 2024	MCCARTHY TERESA	SALE	44.00	13.15K	578.74K	69.02K
Sep 23, 2024	FLANAGAN W. MICHAEL	SALE	44.00	13.15K	578.74K	72.72K
Sep 23, 2024	BOYCE SARAH	SALE	44.00	32.88K	1.45M	234.66K
Sep 19, 2024	LEVIN ARTHUR A	SALE	45.73	5K	228.66K	14.83K
Sep 11, 2024	MCCARTHY TERESA	SALE	40.40	25K	1.01M	57.17K
Sep 11, 2024	FLANAGAN W. MICHAEL	SALE	40.40	14.89K	601.68K	60.87K
Aug 19, 2024	LEVIN ARTHUR A	SALE	45.19	5K	225.95K	14.83K
Aug 06, 2024	BOYCE SARAH	SALE	43.35	28K	1.21M	205.04K
Jul 19, 2024	LEVIN ARTHUR A	SALE	45.01	5K	225.07K	14.83K
Jul 09, 2024	BOYCE SARAH	SALE	39.93	28K	1.12M	205.04K
Jun 20, 2024	LEVIN ARTHUR A	SALE	37.59	5K	187.95K	14.83K
Jun 18, 2024	MCCARTHY TERESA	SALE	39.13	9.86K	385.97K	32.17K
Jun 18, 2024	BOYCE SARAH	SALE	39.13	32.07K	1.26M	142.54K
Jun 18, 2024	FLANAGAN W. MICHAEL	SALE	39.13	10.11K	395.44K	50.77K
Jun 18, 2024	MACLEAN MICHAEL F	SALE	39.13	11.23K	439.34K	57.87K
Jun 14, 2024	BOYCE SARAH	SALE	40.08	35.77K	1.43M	112.12K
Jun 13, 2024	BOYCE SARAH	SALE	40.08	164.23K	6.58M	112.12K
Jun 13, 2024	LEVIN ARTHUR A	SALE	40.08	60K	2.4M	153.87K
Jun 12, 2024	MACLEAN MICHAEL F	SALE	35.72	104.25K	3.72M	44.09K
Jun 12, 2024	LEVIN ARTHUR A	SALE	35.07	40K	1.4M	213.87K
Jun 12, 2024	BOYCE SARAH	SALE	35.73	100K	3.57M	112.12K
Jun 04, 2024	BOYCE SARAH	SALE	27.42	28K	767.78K	112.12K
May 20, 2024	LEVIN ARTHUR A	SALE	29.90	5K	149.48K	14.83K
May 14, 2024	MACLEAN MICHAEL F	SALE	28.28	75K	2.12M	44.09K
May 07, 2024	BOYCE SARAH	SALE	25.54	28K	715.05K	112.12K
Apr 19, 2024	LEVIN ARTHUR A	SALE	22.82	5K	114.12K	14.83K
Apr 03, 2024	LEVIN ARTHUR A	SALE	27.11	20K	542.21K	253.87K
Apr 02, 2024	BOYCE SARAH	SALE	26.25	28K	734.92K	112.12K
Mar 19, 2024	LEVIN ARTHUR A	SALE	23.97	5K	119.85K	14.83K
Mar 13, 2024	MACLEAN MICHAEL F	SALE	24.52	40K	980.76K	44.09K
Mar 12, 2024	LEVIN ARTHUR A	SALE	22.00	2.64K	58.1K	14.83K
Mar 12, 2024	BOYCE SARAH	SALE	22.63	28K	633.68K	112.12K
Mar 08, 2024	BOYCE SARAH	SALE	21.39	84K	1.8M	112.12K
Mar 01, 2024	BOYCE SARAH	SALE	20.13	84K	1.69M	112.12K
Jan 22, 2024	MCCARTHY TERESA	SALE	10.13	2.07K	20.92K	17.04K
Jan 22, 2024	MACLEAN MICHAEL F	SALE	10.13	1.62K	16.37K	16.88K
Jan 22, 2024	BOYCE SARAH	SALE	10.13	5.09K	51.58K	44.01K
Jan 22, 2024	LEVIN ARTHUR A	SALE	10.13	1.86K	18.83K	17.47K
Jan 22, 2024	FLANAGAN W. MICHAEL	SALE	10.13	4.13K	41.83K	35.87K
Mar 15, 2023	LEVIN ARTHUR A	SALE	22.01	100	2.2K	19.33K
Feb 14, 2023	LEVIN ARTHUR A	SALE	24.24	523	12.68K	19.33K
Feb 03, 2023	BOYCE SARAH	SALE	24.26	3.22K	78.14K	53.35K
Feb 02, 2023	BOYCE SARAH	SALE	24.36	45.88K	1.12M	53.35K
Feb 01, 2023	BOYCE SARAH	SALE	24.27	900	21.84K	53.35K
Jan 12, 2023	LEVIN ARTHUR A	SALE	22.00	10K	220.03K	1.33K
Dec 29, 2022	LEVIN ARTHUR A	SALE	22.01	40K	880.57K	1.33K
Aug 24, 2022	BOYCE SARAH	SALE	23.07	14.86K	342.69K	0
Aug 15, 2022	LEVIN ARTHUR A	SALE	22.12	62.5K	1.38M	1.33K
Aug 15, 2022	BOYCE SARAH	SALE	22.47	100	2.25K	0
Aug 12, 2022	LEVIN ARTHUR A	SALE	22.00	14K	308.07K	1.33K
Nov 18, 2021	LEVIN ARTHUR A	SALE	27.89	25K	697.22K	1.33K
Aug 04, 2021	RTW INVESTMENTS, LP	PURCHASE	18.00	800K	14.4M	4.8M
Jun 25, 2021	LEVIN ARTHUR A	SALE	29.14	2.65K	77.13K	1.33K
Jun 24, 2021	LEVIN ARTHUR A	SALE	27.75	100	2.78K	1.33K
Jun 17, 2021	LEVIN ARTHUR A	SALE	27.75	200	5.55K	1.33K
Jun 15, 2021	LEVIN ARTHUR A	SALE	26.02	23.02K	599.07K	0
Jun 14, 2021	LEVIN ARTHUR A	SALE	25.92	14K	362.92K	23.02K
Mar 16, 2021	LEVIN ARTHUR A	SALE	27.87	4.6K	128.18K	0
Jun 16, 2020	RTW INVESTMENTS, LP	PURCHASE	18.00	950K	17.1M	4M
Jun 16, 2020	CORMORANT ASSET MANAGEMENT, LP	PURCHASE	18.00	300K	5.4M	2.51M

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES182.01K24

NET SHARES-182.01K24

SHARES HELD2.2M24

% NET SHARES-108.26%0%

Frequently Asked Questions