How many institutions own REPL stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own REPL shares is 238, representing 104.94% of the company's common stock.

Who are the major shareholders selling Replimune Group, Inc. stock?

DEUTSCHE BANK AG\, in the last quarter, reduced its stake in REPL by -90% restricting it's holding to 53.94 thousand shares of worth nearly $524.34K. ACADIAN ASSET MANAGEMENT LLC also lessened -22.97% of the REPL shares from its portfolio, reducing its holding to 56.72 thousand shares of worth $550.00K. SUSQUEHANNA INTERNATIONAL GROUP, LLP also shunned REPL shares holding by -85.48% last quarter which brought its holding to 251 thousand shares worth $2.44M.

Investors who are buying REPL stock?

As per its latest 13F filing, HRT FINANCIAL LP increased its stake in REPL by 5.48% in the last quarter. The institutional holder raised its holding to 183.59 thousand shares having worth more than $1.78M. ROSALIND ADVISORS, INC. also added 100% more shares of REPL to its portfolio, raising its holding to 1.41 million shares of worth $13.71M. STATE STREET CORP also increased its REPL shares holding by 26.3% which brought its holding to 3.69 million shares worth $35.90M.

REPL's major insiders: who are they?

The insider with the most stakes in REPL is Omega Fund IV, L.P. , at the company. Additionally, REPL stock is highly held by Stampacchia Otello and director Coffin Robert among others.

Did an insider recently sell REPL stock?

Company executives, directors, and other insiders own 2% percent of Replimune Group, Inc.'s stock. Within the last six months, there have been 4 transaction(s) in which REPL insiders have sold stock, totaling 25.63K shares. Insiders that have sold shares include DHINGRA KAPIL, PATEL SUSHIL, and XYNOS KONSTANTINOS.

Which insider recently purchased REPL stock?

There have been 0 transaction(s) during the past 6-months in which Replimune Group, Inc. insiders have bought stock, totalling 0 shares

How much of REPL does insiders own?

Around 596.35K Replimune Group, Inc. shares are held by insiders, which represents about 2% of REPL stock.

Who is the insider with the largest stake?

REPL , Omega Fund IV, L.P. holds the largest portfolio of the company's shares. REPL shares owned by Omega total nearly 4.76 million.

Which institution holds the most shares in REPL?

HRT FINANCIAL LP is the largest institutional owner in REPL which holds 183.59 thousand shares worth $1.78M or 0.2% of the total REPL shares outstanding followed by ROSALIND ADVISORS, INC. with ownership of 1.41 million shares representing 1.53% of the REPL ownership. STATE STREET CORP is the third largest stakeholder with 3.69 million shares or 4.01% of the ownership worth more than $35.90M.

Is Replimune Group, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the REPL is concerned, it is a stock which is optionable.

Is there a short position on REPL's shares?

Number of REPL shares short is 19.20M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding REPL shares are there?

As of today, 78.06M shares of REPL are outstanding.

Is there many float in REPL stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, REPL has 49.98M shares in float.

REPL short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for REPL is 0.91.

Replimune Group (REPL) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares24.59

Short Percent Of Float46.2

Shares Outstanding78.06M

Shares Float49.98M

Shares Short19.20M

Short Ratio0.91

46.2%

Short % of Float

24.59%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

2% Percentage of Shares held by All Insiders

104.94% Percentage of Shares held by All Institutions

107.09% Percentage of Float held by Institutions

238

Number of Institutions Holding Shares

Institutional Ownership

About 104.94% of REPL shares are held by financial institutions. HRT FINANCIAL LP is the top corporate investor, holding 183.59K shares valued at $1.78M. A 0.2% stake in Replimune Group, Inc. is owned by the company. ROSALIND ADVISORS, INC. owns 1.41M shares valued at $13.71M, which translates its holding of 1.53% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	HRT FINANCIAL LP	0.2%	183.59K	1.78M	9.54K	+5.48%
Dec 31, 2025	ROSALIND ADVISORS, INC.	1.53%	1.41M	13.71M	1.41M	+100.00%
Dec 31, 2025	STATE STREET CORP	4.01%	3.69M	35.9M	768.98K	+26.30%
Dec 31, 2025	VANGUARD GROUP INC	4.1%	3.78M	36.7M	296.8K	+8.53%
Dec 31, 2025	BLACKROCK, INC.	6.58%	6.07M	59M	293.74K	+5.09%
Dec 31, 2025	PROFUND ADVISORS LLC	0.06%	52.15K	506.85K	28.48K	+120.31%
Dec 31, 2025	DEUTSCHE BANK AG\	0.06%	53.94K	524.34K	-485.62K	-90.00%
Dec 31, 2025	ACADIAN ASSET MANAGEMENT LLC	0.06%	56.72K	550K	-16.92K	-22.97%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	0.23%	215.33K	2.09M	106.05K	+97.04%
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.27%	251K	2.44M	-1.48M	-85.48%
Dec 31, 2025	JUMP FINANCIAL, LLC	0.32%	296.84K	2.89M	53.08K	+21.77%
Dec 31, 2025	TWO SIGMA INVESTMENTS, LP	0.48%	444.07K	4.32M	286.58K	+181.95%
Dec 31, 2025	JANE STREET GROUP, LLC	0.63%	584.33K	5.68M	55	+0.01%
Dec 31, 2025	BOXER CAPITAL MANAGEMENT, LLC	0.81%	750K	7.29M	-300K	-28.57%
Dec 31, 2025	DIADEMA PARTNERS LP	0.25%	231K	2.25M	231K	+100.00%
Dec 31, 2025	ERSTE ASSET MANAGEMENT GMBH	2.3%	2.12M	20.62M	490K	+30.06%
Dec 31, 2025	D. E. SHAW & CO., INC.	2.79%	2.58M	25.03M	2.17M	+538.18%
Dec 31, 2025	FCPM III SERVICES B.V.	3.05%	2.81M	27.3M	-1.35M	-32.46%
Dec 31, 2025	FMR LLC	3.23%	2.98M	28.98M	1.62M	+119.06%
Dec 31, 2025	RTW INVESTMENTS, LP	7.75%	7.14M	69.4M	744.62K	+11.64%
Dec 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	8.96%	8.26M	80.31M	-44.14K	-0.53%
Dec 31, 2025	BAKER BROS. ADVISORS LP	11.98%	11.05M	107.36M	0	0
Dec 31, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.02%	18.45K	179.29K	0	0
Dec 31, 2025	AXQ CAPITAL, LP	0.02%	19.86K	193.06K	19.86K	+100.00%
Dec 31, 2025	WALLEYE TRADING LLC	0.08%	74.5K	724.14K	36.2K	+94.52%
Dec 31, 2025	DLD ASSET MANAGEMENT, LP	0.12%	112.7K	1.09M	72.7K	+181.75%
Dec 31, 2025	TUDOR INVESTMENT CORP ET AL	0.14%	128.38K	1.25M	107.62K	+518.25%
Dec 31, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.15%	140.91K	1.37M	32.32K	+29.76%
Dec 31, 2025	AMERICAN CENTURY COMPANIES INC	0.16%	148.09K	1.44M	8.35K	+5.98%
Dec 31, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.17%	153.65K	1.49M	153.65K	+100.00%
Dec 31, 2025	QUINN OPPORTUNITY PARTNERS LLC	0.43%	392.92K	3.82M	-257.81K	-39.62%
Dec 31, 2025	HIGHTOWER ADVISORS, LLC	0.02%	20.12K	195.6K	3.99K	+24.76%
Dec 31, 2025	CAPTION MANAGEMENT, LLC	0.25%	228.57K	2.22M	58.57K	+34.45%
Dec 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.44%	405.05K	3.94M	405.05K	+100.00%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.5%	460.7K	4.48M	446.94K	+3,247.65%
Dec 31, 2025	NORTHERN TRUST CORP	0.59%	539.6K	5.24M	-74.59K	-12.14%
Dec 31, 2025	WOODLINE PARTNERS LP	0.62%	570.99K	5.55M	-285K	-33.29%
Dec 31, 2025	NAN FUNG TRINITY (HK) LTD	0.62%	575.53K	5.59M	110K	+23.63%
Dec 31, 2025	INVESCO LTD.	0.67%	613.02K	5.96M	458.71K	+297.29%
Dec 31, 2025	JEFFERIES FINANCIAL GROUP INC.	0.77%	714.23K	6.94M	714.23K	+100.00%
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	0.91%	834.56K	8.11M	-755.18K	-47.50%
Dec 31, 2025	TORONTO DOMINION BANK	2.42%	2.23M	21.67M	857.48K	+62.50%
Dec 31, 2025	CITIGROUP INC	0.02%	20.19K	196.29K	13.07K	+183.35%
Dec 31, 2025	NISA INVESTMENT ADVISORS, LLC	0.02%	20.95K	203.65K	20.06K	+2,243.62%
Dec 31, 2025	BALLENTINE PARTNERS, LLC	0.03%	23.67K	230.02K	1.72K	+7.84%
Dec 31, 2025	DIMENSIONAL FUND ADVISORS LP	1.21%	1.12M	10.88M	-132.14K	-10.56%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.9%	1.75M	17.02M	54.75K	+3.23%
Dec 31, 2025	REDMILE GROUP, LLC	1.19%	1.1M	10.69M	563.94K	+105.25%
Dec 31, 2025	ALLY BRIDGE GROUP (NY) LLC	1.3%	1.2M	11.66M	-2.4M	-66.67%
Dec 31, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	24.7K	240.12K	0	0
Dec 31, 2025	DYNAMIC TECHNOLOGY LAB PRIVATE LTD	0.03%	25.91K	252K	5.78K	+28.73%
Dec 31, 2025	NUVEEN, LLC	0.06%	57.61K	560.01M	0	0
Dec 31, 2025	SQUAREPOINT OPS LLC	0.07%	67.27K	653.87K	-4.54K	-6.32%
Dec 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	1.35%	1.24M	12.07M	262.43K	+26.81%
Dec 31, 2025	COMMODORE CAPITAL LP	1.55%	1.43M	13.85M	1.43M	+100.00%
Dec 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.96%	1.81M	17.57M	1.81M	+100.00%
Dec 31, 2025	TEMA ETFS LLC	0.06%	51.28K	498.46K	8.32K	+19.35%
Dec 31, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.05%	44.05K	451.46K	1.27K	+2.97%
Dec 31, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	34.33K	333.67K	-6.21K	-15.32%
Dec 31, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.03%	32.09K	311.94K	19.65K	+157.82%
Dec 31, 2025	GSA CAPITAL PARTNERS LLP	0.03%	29.15K	283K	9.86K	+51.13%
Dec 31, 2025	QUEST PARTNERS LLC	0.03%	28.08K	272.94K	3.05K	+12.19%
Dec 31, 2025	SG AMERICAS SECURITIES, LLC	0.08%	71.96K	699K	-26.78K	-27.12%
Dec 31, 2025	WALLEYE CAPITAL LLC	0.09%	86.2K	837.86K	26K	+43.19%
Dec 31, 2025	JPMORGAN CHASE & CO	1%	925.17K	8.99M	887.16K	+2,333.64%
Dec 31, 2025	MORGAN STANLEY	0.88%	814.89K	7.92M	-560.63K	-40.76%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	0.71%	658.1K	6.4M	-476.66K	-42.01%
Dec 31, 2025	UBS GROUP AG	0.66%	604.31K	5.87M	-297.32K	-32.98%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.64%	587.89K	5.71M	72.49K	+14.06%
Dec 31, 2025	BARCLAYS PLC	0.32%	292.19K	2.84M	-163.68K	-35.90%
Dec 31, 2025	TD ASSET MANAGEMENT INC	0.29%	266.48K	2.59M	-17.57K	-6.18%
Dec 31, 2025	CITADEL ADVISORS LLC	0.27%	250.2K	2.43M	-4.8K	-1.88%
Dec 31, 2025	OMEGA FUND MANAGEMENT, LLC	0.27%	248.67K	2.42M	0	0
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.23%	209.22K	2.03M	7.92K	+3.93%
Dec 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.23%	208.67K	2.03M	-18.35K	-8.08%
Dec 31, 2025	RHUMBLINE ADVISERS	0.1%	89.31K	868.09M	-10K	-10.07%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.1%	90.72K	881.84K	-64.66K	-41.61%
Dec 31, 2025	MARSHALL WACE, LLP	0.1%	93.59K	909.65K	93.59K	+100.00%
Dec 31, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.19%	178.91K	1.75M	-38.68K	-17.77%
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.17%	157.5K	659.92K	135.08K	+602.46%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.17%	155.38K	651.04K	-12.63K	-7.51%
Sep 30, 2025	HRT FINANCIAL LP	0.19%	174.05K	729K	82.88K	+90.90%
Sep 30, 2025	RAYMOND JAMES FINANCIAL INC	0.2%	186.99K	783.51K	179.58K	+2,422.17%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.22%	201.31K	843.48K	-5.26K	-2.54%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.24%	1.13M	4.75M	17.42K	+1.56%
Sep 30, 2025	ERSTE ASSET MANAGEMENT GMBH	1.78%	1.63M	7.07M	1.62M	+13,597.48%
Sep 30, 2025	DIADEMA PARTNERS LP	0.67%	612.3K	2.57M	612.3K	+100.00%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.56%	515.4K	2.16M	-37.76K	-6.83%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	1.89%	1.73M	7.24M	1.61M	+1,381.41%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	2.87%	2.63M	11.01M	2.2M	+507.44%
Sep 30, 2025	BRAIDWELL LP	3.01%	2.75M	11.52M	2.33M	+550.31%
Sep 30, 2025	STATE STREET CORP	3.2%	2.92M	12.25M	471.44K	+19.22%
Sep 30, 2025	TANG CAPITAL MANAGEMENT LLC	3.72%	3.4M	14.25M	200K	+6.25%
Sep 30, 2025	ALLY BRIDGE GROUP (NY) LLC	3.93%	3.6M	15.08M	3.6M	+100.00%
Sep 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	3.97%	3.63M	15.21M	2.92M	+409.43%
Sep 30, 2025	FCPM III SERVICES B.V.	4.54%	4.16M	17.42M	248.67K	+6.36%
Sep 30, 2025	RTW INVESTMENTS, LP	6.99%	6.4M	26.8M	4.33M	+209.72%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	9.08%	8.31M	34.81M	-2.51M	-23.23%
Sep 30, 2025	BAKER BROS. ADVISORS LP	12.07%	11.05M	46.28M	0	0
Sep 30, 2025	OMEGA FUND MANAGEMENT, LLC	0.27%	248.67K	1.04M	-1.73M	-87.41%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.31%	284.05K	1.19M	-43.4K	-13.25%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.33%	300K	1.26M	225K	+300.00%
Sep 30, 2025	JANE STREET GROUP, LLC	0.37%	340.7K	1.43M	3.9K	+1.16%
Sep 30, 2025	CITADEL ADVISORS LLC	0.28%	255K	1.07M	93.4K	+57.80%
Sep 30, 2025	NAN FUNG TRINITY (HK) LTD	0.51%	465.53K	1.95M	0	0
Sep 30, 2025	DYNAMIC TECHNOLOGY LAB PRIVATE LTD	0.02%	20.12K	85K	20.12K	+100.00%
Sep 30, 2025	BALLENTINE PARTNERS, LLC	0.02%	21.94K	91.95K	21.94K	+100.00%
Sep 30, 2025	PROFUND ADVISORS LLC	0.03%	23.67K	99.17K	6.65K	+39.05%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	24.7K	103.51K	-11.16K	-31.12%
Sep 30, 2025	QUEST PARTNERS LLC	0.03%	25.03K	104.88K	15.17K	+153.93%
Sep 30, 2025	TCG ADVISORY SERVICES, LLC	0.03%	25.37K	106.29K	0	0
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.03%	26.77K	112.15K	-26.43K	-49.68%
Sep 30, 2025	GROUP ONE TRADING, L.P.	0.03%	28.86K	120.92M	9.14K	+46.33%
Sep 30, 2025	ALPS ADVISORS INC	0.04%	37.29K	156.23K	-4.32K	-10.37%
Sep 30, 2025	JPMORGAN CHASE & CO	0.04%	38.02K	159.29K	1.71K	+4.72%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	40.54K	169.85K	-60	-0.15%
Sep 30, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.05%	42.77K	179.22K	-648	-1.49%
Sep 30, 2025	TEMA ETFS LLC	0.05%	42.97K	180.03K	2.06K	+5.04%
Sep 30, 2025	NEOS INVESTMENT MANAGEMENT LLC	0.05%	42.97K	180.03K	2.06K	+5.04%
Sep 30, 2025	DIAMETRIC CAPITAL, LP	0.05%	50K	209.5K	50K	+100.00%
Sep 30, 2025	NUVEEN, LLC	0.06%	57.61K	241.4K	-69.71K	-54.75%
Sep 30, 2025	NAN FUNG GROUP HOLDINGS LTD	0.07%	63.72K	266.98K	0	0
Sep 30, 2025	SWISS NATIONAL BANK	0.08%	73.5K	307.97K	0	0
Sep 30, 2025	ACADIAN ASSET MANAGEMENT LLC	0.08%	73.64K	306K	73.64K	+100.00%
Sep 30, 2025	FRANKLIN RESOURCES INC	0.09%	81.23K	340.37K	81.23K	+100.00%
Sep 30, 2025	PANAGORA ASSET MANAGEMENT INC	0.09%	83.25K	348.8K	-17.47K	-17.35%
Sep 30, 2025	SG AMERICAS SECURITIES, LLC	0.11%	98.73K	414K	88.53K	+868.05%
Sep 30, 2025	RHUMBLINE ADVISERS	0.11%	99.32K	416.12K	-2.69K	-2.64%
Sep 30, 2025	HAP TRADING, LLC	0.11%	100K	10M	100K	+100.00%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.12%	108.59K	455K	29.06K	+36.54%
Sep 30, 2025	Y-INTERCEPT (HONG KONG) LTD	0.13%	121.4K	508.65K	121.4K	+100.00%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.15%	139.74K	585.49K	6.63K	+4.98%
Sep 30, 2025	VANGUARD GROUP INC	3.8%	3.48M	14.58M	9.71K	+0.28%
Sep 30, 2025	BLACKROCK, INC.	6.31%	5.78M	24.2M	45.51K	+0.79%
Sep 30, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.24%	217.59K	911.69K	-51.53K	-19.15%
Sep 30, 2025	DLD ASSET MANAGEMENT, LP	0.32%	292.6K	1.22M	292.6K	+100.00%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.25%	227.02K	951.2K	-717.49K	-75.96%
Sep 30, 2025	JUMP FINANCIAL, LLC	0.27%	243.77K	1.02M	243.77K	+100.00%
Sep 30, 2025	STATE OF WISCONSIN INVESTMENT BOARD	0.28%	258.96K	1.09M	184.18K	+246.29%
Sep 30, 2025	D. E. SHAW & CO., INC.	0.44%	403.5K	1.69M	-103.1K	-20.35%
Sep 30, 2025	BARCLAYS PLC	0.5%	455.86K	1.91M	83.75K	+22.51%
Sep 30, 2025	REDMILE GROUP, LLC	0.59%	535.82K	2.25M	-4.13M	-88.51%
Sep 30, 2025	DEUTSCHE BANK AG\	0.59%	539.57K	2.26M	6.56K	+1.23%
Sep 30, 2025	NORTHERN TRUST CORP	0.67%	614.19K	2.57M	27.43K	+4.67%
Sep 30, 2025	CAPTION MANAGEMENT, LLC	0.93%	852.2K	3.57M	59.8K	+7.55%
Sep 30, 2025	QUINN OPPORTUNITY PARTNERS LLC	0.71%	650.72K	2.73M	650.72K	+100.00%
Sep 30, 2025	UBS GROUP AG	0.99%	901.63K	3.78M	658.23K	+270.44%
Sep 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	1.07%	978.89K	4.1M	968.49K	+9,312.44%
Sep 30, 2025	BOXER CAPITAL MANAGEMENT, LLC	1.15%	1.05M	4.4M	-1.16M	-52.52%
Sep 30, 2025	TORONTO DOMINION BANK	1.5%	1.37M	5.75M	1.37M	+100.00%
Sep 30, 2025	WOODLINE PARTNERS LP	0.94%	855.99K	3.59M	0	0
Sep 30, 2025	CENTIVA CAPITAL, LP	0.27%	248.8K	1.04M	98.8K	+65.87%
Sep 30, 2025	MORGAN STANLEY	1.5%	1.38M	5.76M	453.86K	+49.24%
Sep 30, 2025	READYSTATE ASSET MANAGEMENT LP	2.86%	2.62M	10.98M	2.43M	+1,296.23%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	1.37%	1.25M	5.24M	86.05K	+7.38%
Sep 30, 2025	FMR LLC	1.49%	1.36M	5.7M	969.42K	+247.52%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.85%	1.7M	7.11M	71.4K	+4.40%
Sep 30, 2025	SIMPLEX TRADING, LLC	0.16%	150.45K	630K	111.9K	+290.30%
Sep 30, 2025	INVESCO LTD.	0.17%	154.3K	646.52K	34.97K	+29.31%
Jun 30, 2025	BRAIDWELL LP	0.46%	422.89K	3.93M	-1.04M	-71.07%
Jun 30, 2025	TANG CAPITAL MANAGEMENT LLC	3.5%	3.2M	29.73M	300K	+10.34%
Jun 30, 2025	ENSIGN PEAK ADVISORS, INC	0.35%	322.4K	3M	0	0
Jun 30, 2025	PRELUDE CAPITAL MANAGEMENT, LLC	0.14%	123.78K	1.15M	41.22K	+49.92%
Jun 30, 2025	STATE OF WISCONSIN INVESTMENT BOARD	0.08%	74.78K	694.72K	27.08K	+56.76%
Jun 30, 2025	BAKER BROS. ADVISORS LP	12.07%	11.05M	102.61M	0	0
Jun 30, 2025	RTW INVESTMENTS, LP	2.26%	2.07M	19.18M	0	0
Jun 30, 2025	SOFINNOVA INVESTMENTS, INC.	1.64%	1.5M	13.94M	1.5M	+100.00%
Jun 30, 2025	MORGAN STANLEY	1.01%	921.66K	8.56B	-6.6K	-0.71%
Jun 30, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.98%	896.71K	8.33M	-53.69K	-5.65%
Jun 30, 2025	WOODLINE PARTNERS LP	0.94%	855.99K	7.95M	750	+0.09%
Jun 30, 2025	ALLY BRIDGE GROUP (NY) LLC	0.58%	528.49K	4.91M	528.49K	+100.00%
Jun 30, 2025	ARTISAN PARTNERS LIMITED PARTNERSHIP	0.56%	511.37K	4.75M	-53.7K	-9.50%
Jun 30, 2025	TD ASSET MANAGEMENT INC	0.36%	327.45K	3.04M	51.6K	+18.71%
Jun 30, 2025	SECTORAL ASSET MANAGEMENT INC	0.25%	231.65K	2.15M	231.65K	+100.00%
Jun 30, 2025	MOODY ALDRICH PARTNERS LLC	0.21%	194.45K	1.81M	-2.93K	-1.49%
Jun 30, 2025	READYSTATE ASSET MANAGEMENT LP	0.21%	187.72K	1.74M	187.72K	+100.00%
Jun 30, 2025	VELAN CAPITAL INVESTMENT MANAGEMENT LP	0.2%	183.08K	1.7M	1K	+0.55%
Jun 30, 2025	CANDRIAM S.C.A.	0.19%	171.53K	1.59M	171.53K	+100.00%
Jun 30, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.17%	157.55K	1.46M	157.55K	+100.00%
Jun 30, 2025	CENTIVA CAPITAL, LP	0.16%	150K	1.39M	150K	+100.00%
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	0.15%	133.11K	1.24M	-132	-0.10%
Jun 30, 2025	TREXQUANT INVESTMENT LP	0.14%	131.49K	1.22M	-21.05K	-13.80%
Jun 30, 2025	SATURN V CAPITAL MANAGEMENT LLC	0.14%	128.92K	1.2M	128.92K	+100.00%
Jun 30, 2025	UBS OCONNOR LLC	0.12%	114.08K	1.06M	-136.34K	-54.44%
Jun 30, 2025	HRT FINANCIAL LP	0.1%	91.18K	847K	91.18K	+100.00%
Jun 30, 2025	ALGERT GLOBAL LLC	0.09%	79.37K	737K	33.55K	+73.22%
Jun 30, 2025	ECOR1 CAPITAL, LLC	0.93%	850.34K	7.9M	0	0
Jun 30, 2025	BLACKROCK, INC.	6.26%	5.73M	53.24M	-331.51K	-5.47%
Jun 30, 2025	REDMILE GROUP, LLC	5.1%	4.66M	43.34M	-233.74K	-4.77%
Jun 30, 2025	J. GOLDMAN & CO LP	0.07%	67.6K	628K	67.6K	+100.00%
Jun 30, 2025	ENCOMPASS MORE ASSET MANAGEMENT	0.07%	66.73K	619.92K	66.73K	+100.00%
Jun 30, 2025	NAN FUNG GROUP HOLDINGS LTD	0.07%	63.72K	591.95K	-350.53K	-84.62%
Jun 30, 2025	XTX TOPCO LTD	0.07%	62.79K	583.36K	62.79K	+100.00%
Jun 30, 2025	BREVAN HOWARD CAPITAL MANAGEMENT LP	0.06%	58.24K	541.07K	58.24K	+100.00%
Jun 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.06%	53.81K	499.85K	1.03K	+1.94%
Jun 30, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.05%	43.42K	403.39K	43.42K	+100.00%
Jun 30, 2025	ALPS ADVISORS INC	0.05%	41.6K	386.48K	-14.73K	-26.14%
Jun 30, 2025	NEOS INVESTMENT MANAGEMENT LLC	0.04%	40.91K	380.02K	3.38K	+9.02%
Jun 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.04%	35.86K	333.18K	-4.85K	-11.91%
Jun 30, 2025		0.36%	330.34K	3.07M	-25.3K	-7.11%
Jun 30, 2025	MARSHALL WACE, LLP	2.04%	1.87M	17.34M	-621.16K	-24.97%
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.78%	712.54K	6.62M	616.57K	+642.41%
Jun 30, 2025	D. E. SHAW & CO., INC.	0.55%	506.6K	4.71B	-289.98K	-36.40%
Jun 30, 2025	CANTOR FITZGERALD, L. P.	0.22%	200K	1.86M	200K	+100.00%
Jun 30, 2025	FISHER ASSET MANAGEMENT, LLC	0.09%	81.95K	761.31K	0	0
Jun 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.09%	79.53K	738.84K	923	+1.17%
Jun 30, 2025	STATE STREET CORP	2.68%	2.45M	22.79M	54.64K	+2.28%
Jun 30, 2025	OMEGA FUND MANAGEMENT, LLC	2.16%	1.98M	18.35M	0	0
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.77%	1.62M	15.09M	-48.72K	-2.91%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	1.27%	1.17M	10.83M	215.58K	+22.70%
Jun 30, 2025	BIOIMPACT CAPITAL LLC	1.08%	983.78K	9.14M	-3.26K	-0.33%
Jun 30, 2025	BARCLAYS PLC	0.41%	372.11K	3.46M	217.31K	+140.39%
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.26%	234.81K	2.18M	-223.87K	-48.81%
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.25%	229.3K	2.13M	194.6K	+560.81%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.23%	206.56K	1.92M	17.39K	+9.19%
Jun 30, 2025	FCPM III SERVICES B.V.	4.27%	3.91M	36.32M	0	0
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	1.03%	944.51K	8.77M	8.15K	+0.87%
Jun 30, 2025	ROSALIND ADVISORS, INC.	0.98%	900K	8.36M	50K	+5.88%
Jun 30, 2025	CAPTION MANAGEMENT, LLC	0.49%	445.6K	4.14M	445.6K	+100.00%
Jun 30, 2025	NORTHERN TRUST CORP	0.64%	586.77K	5.45M	-46.23K	-7.30%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.6%	553.16K	5.14M	1.12K	+0.20%
Jun 30, 2025	DEUTSCHE BANK AG\	0.58%	533.01K	4.95M	-30.69K	-5.45%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.55%	505.11K	4.69M	143.83K	+39.81%
Jun 30, 2025	NAN FUNG TRINITY (HK) LTD	0.51%	465.53K	4.32M	465.53K	+100.00%
Jun 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.47%	432.65K	4.02M	99.42K	+29.83%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.45%	412.7K	3.83M	412.7K	+100.00%
Jun 30, 2025	FMR LLC	0.43%	391.66K	3.64M	-11.71K	-2.90%
Jun 30, 2025	JANE STREET GROUP, LLC	0.37%	336.8K	3.13M	336.8K	+100.00%
Jun 30, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.29%	269.12K	2.5M	61.04K	+29.34%
Jun 30, 2025	UBS GROUP AG	0.27%	243.4K	2.26M	95.09K	+64.12%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	11.82%	10.82M	100.51M	-34.62K	-0.32%
Jun 30, 2025	VANGUARD GROUP INC	3.79%	3.47M	32.23M	-363.35K	-9.48%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	1.22%	1.12M	10.38B	427.16K	+61.89%
Jun 30, 2025	CITADEL ADVISORS LLC	0.3%	277.47K	2.58B	254.72K	+1,119.40%
Jun 30, 2025	BOXER CAPITAL MANAGEMENT, LLC	2.42%	2.21M	20.54M	415K	+23.10%
Jun 30, 2025	CATALIO CAPITAL MANAGEMENT, LP	0.36%	330.34K	3.07M	-25.3K	-7.11%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	1.47%	1.22M	11.93M	33.57K	+2.82%
Mar 31, 2025	BRAIDWELL LP	1.75%	1.46M	14.25M	-15.28K	-1.03%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	2%	1.67M	16.31M	243.1K	+17.00%
Mar 31, 2025	OMEGA FUND MANAGEMENT, LLC	2.37%	1.98M	19.26M	0	0
Mar 31, 2025	VANGUARD GROUP INC	4.59%	3.83M	37.37M	237.19K	+6.60%
Mar 31, 2025	REDMILE GROUP, LLC	5.87%	4.9M	47.76M	-7K	-0.14%
Mar 31, 2025	MARSHALL WACE, LLP	2.98%	2.49M	24.25M	1.59M	+177.59%
Mar 31, 2025	TANG CAPITAL MANAGEMENT LLC	3.47%	2.9M	28.28M	200K	+7.41%
Mar 31, 2025	STATE STREET CORP	2.87%	2.4M	23.38M	194K	+8.80%
Mar 31, 2025	SOFINNOVA INVESTMENTS, INC.	2.97%	2.48M	24.18M	-669.58K	-21.26%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	13%	10.85M	105.83M	-109.05K	-0.99%
Mar 31, 2025	BAKER BROS. ADVISORS LP	13.23%	11.05M	107.69M	0	0
Mar 31, 2025	INVESCO LTD.	0.39%	322.34K	3.14M	234.34K	+266.27%
Mar 31, 2025	ROSALIND ADVISORS, INC.	1.02%	850K	8.29M	590K	+226.92%
Mar 31, 2025	NORTHERN TRUST CORP	0.76%	633K	6.17M	43.36K	+7.35%
Mar 31, 2025	ARTISAN PARTNERS LIMITED PARTNERSHIP	0.68%	565.08K	5.51M	-45.94K	-7.52%
Mar 31, 2025	DEUTSCHE BANK AG\	0.68%	563.7K	5.5M	2.14K	+0.38%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.66%	552.05K	5.38M	43.65K	+8.59%
Mar 31, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.55%	458.67K	4.47M	295.37K	+180.88%
Mar 31, 2025	NAN FUNG GROUP HOLDINGS LTD	0.5%	414.25K	4.04M	92.5K	+28.75%
Mar 31, 2025	FMR LLC	0.48%	403.37K	3.93M	56.09K	+16.15%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.43%	361.28K	3.52M	336.85K	+1,379.25%
Mar 31, 2025		0.43%	355.64K	3.47M	355.64K	+100.00%
Mar 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.4%	333.24K	3.25M	333.24K	+100.00%
Mar 31, 2025	ENSIGN PEAK ADVISORS, INC	0.39%	322.4K	3.14M	322.4K	+100.00%
Mar 31, 2025	EXOME ASSET MANAGEMENT LLC	0.35%	294.85K	2.87M	240.11K	+438.65%
Mar 31, 2025	TD ASSET MANAGEMENT INC	0.33%	275.85K	2.69M	-18.45K	-6.27%
Mar 31, 2025	JANE STREET GROUP, LLC	0.32%	264.9K	2.58M	-51.39K	-16.25%
Mar 31, 2025	UBS OCONNOR LLC	0.3%	250.42K	2.44M	8.85K	+3.66%
Mar 31, 2025	JPMORGAN CHASE & CO	0.26%	220.59K	2.15M	-266.02K	-54.67%
Mar 31, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.25%	208.08K	2.03M	14.07K	+7.25%
Mar 31, 2025	MOODY ALDRICH PARTNERS LLC	0.24%	197.39K	1.92M	197.39K	+100.00%
Mar 31, 2025	PDT PARTNERS, LLC	0.19%	158.76K	1.55M	-34	-0.02%
Mar 31, 2025	WELLS FARGO & COMPANY/MN	0.19%	158.28K	1.54M	80.91K	+104.57%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.19%	156.24K	1.52M	-700	-0.45%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.19%	155.9K	1.52M	110.81K	+245.71%
Mar 31, 2025	BARCLAYS PLC	0.19%	154.8K	1.51M	-12.53K	-7.49%
Mar 31, 2025	WOODLINE PARTNERS LP	1.02%	855.24K	8.34M	929	+0.11%
Mar 31, 2025	MORGAN STANLEY	1.11%	928.26K	9.05M	-119.37K	-11.39%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	1.12%	936.36K	9.13M	-160.38K	-14.62%
Mar 31, 2025	RTW INVESTMENTS, LP	2.47%	2.07M	20.13M	0	0
Mar 31, 2025	D. E. SHAW & CO., INC.	0.95%	796.58K	7.77M	-176K	-18.10%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.83%	690.17K	6.73M	119.15K	+20.87%
Mar 31, 2025	BLACKROCK, INC.	7.26%	6.06M	59.1M	495.5K	+8.90%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.23%	189.18K	1.84M	14.66K	+8.40%
Mar 31, 2025	VELAN CAPITAL INVESTMENT MANAGEMENT LP	0.22%	182.08K	1.78M	716	+0.39%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	1.14%	949.87K	9.27M	171.71K	+22.07%
Mar 31, 2025	PARKMAN HEALTHCARE PARTNERS LLC	1.14%	950.4K	9.27M	80.64K	+9.27%
Mar 31, 2025	BIOIMPACT CAPITAL LLC	1.18%	987.04K	9.62M	37.04K	+3.90%
Mar 31, 2024	RHUMBLINE ADVISERS	0.12%	79.19K	646.98K	2.03K	+2.63%
Mar 31, 2024	GHOST TREE CAPITAL, LLC	0.98%	650K	5.31M	250K	+62.50%
Mar 31, 2024	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.2%	802.98K	6.56M	-1.01M	-55.68%
Mar 31, 2024	D. E. SHAW & CO., INC.	1.5%	997.79K	8.15M	754.78K	+310.60%
Mar 31, 2024	MORGAN STANLEY	3.98%	2.65M	21.68M	-1.79M	-40.32%
Mar 31, 2024	CAMBER CAPITAL MANAGEMENT LP	4.13%	2.75M	22.47M	1.75M	+175.00%
Mar 31, 2024	PANAGORA ASSET MANAGEMENT INC	0.08%	56.61K	462.5K	56.61K	+100.00%
Mar 31, 2024	BNP PARIBAS ARBITRAGE, SNC	0.09%	58.73K	479.78K	-137.53K	-70.08%
Mar 31, 2024	ENTROPY TECHNOLOGIES, LP	0.09%	59.33K	484.69K	9.18K	+18.31%
Mar 31, 2024	LOS ANGELES CAPITAL MANAGEMENT LLC	0.1%	66.41K	542.53K	30.2K	+83.43%
Mar 31, 2024	SWISS NATIONAL BANK	0.1%	69.8K	570.27K	0	0
Mar 31, 2024	FISHER ASSET MANAGEMENT, LLC	0.12%	77.66K	634.51K	0	0
Mar 31, 2024	DEUTSCHE BANK AG\	0.78%	522.05K	4.27M	384.27K	+278.90%
Mar 31, 2024	ALGERT GLOBAL LLC	0.12%	79.69K	651K	15.72K	+24.57%
Mar 31, 2024	INVESCO LTD.	0.13%	86.66K	707.99K	64.44K	+290.00%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.11%	74.4K	607.85K	74.4K	+100.00%
Mar 31, 2024	PROFUND ADVISORS LLC	0.15%	98.32K	803.25M	24.08K	+32.44%
Mar 31, 2024	TREXQUANT INVESTMENT LP	0.15%	100.43K	820.55K	100.43K	+100.00%
Mar 31, 2024	WOODLINE PARTNERS LP	0.44%	293.62K	2.4M	0	0
Mar 31, 2024	BAKER BROS. ADVISORS LP	14.32%	9.55M	77.99M	0	0
Mar 31, 2024	BARCLAYS PLC	0.16%	108.53K	885K	-181.97K	-62.64%
Mar 31, 2024	ACADIAN ASSET MANAGEMENT LLC	0.17%	113.65K	927K	113.65K	+100.00%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.22%	148.17K	1.21M	-6.58K	-4.25%
Mar 31, 2024	JANE STREET GROUP, LLC	0.24%	157.82K	1.29M	-85.69K	-35.19%
Mar 31, 2024	SCHONFELD STRATEGIC ADVISORS LLC	0.24%	158.29K	1.29M	115.9K	+273.38%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.24%	161.05K	1.32M	127.2K	+375.74%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.24%	162.76K	1.33M	-5.82K	-3.45%
Mar 31, 2024	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.26%	171.02K	1.4M	6.79K	+4.14%
Mar 31, 2024	NAN FUNG GROUP HOLDINGS LTD	0.31%	204.94K	1.67M	20.2K	+10.93%
Mar 31, 2024	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.32%	212.65K	1.74M	32.21K	+17.85%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.33%	221.22K	1.81M	-173.49K	-43.95%
Mar 31, 2024	TWO SIGMA ADVISERS, LP	0.33%	222.6K	1.82M	19.9K	+9.82%
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.36%	238.85K	1.95M	-28.8K	-10.76%
Mar 31, 2024	AMUNDI	0.37%	248.08K	1.73M	73.63K	+42.21%
Mar 31, 2024	JPMORGAN CHASE & CO	0.41%	272.13K	2.22M	-32.89K	-10.78%
Mar 31, 2024	CLEARBRIDGE INVESTMENTS, LLC	0.42%	277.97K	2.27M	7.27K	+2.69%
Mar 31, 2024	FMR LLC	0.43%	286.48K	2.34M	-539.38K	-65.31%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.59%	390.03K	3.19M	169.38K	+76.77%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.63%	418.66K	3.42M	16.72K	+4.16%
Mar 31, 2024	NORTHERN TRUST CORP	0.73%	483.64K	3.95M	1.81K	+0.38%
Mar 31, 2024	EMERALD ADVISERS, LLC	0.74%	492.22K	4.02M	-46.62K	-8.65%
Mar 31, 2024	CITIGROUP INC	0.81%	542.49K	4.43M	359.23K	+196.02%
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	0.96%	642.08K	5.25M	178.68K	+38.56%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	1.79%	1.19M	9.74M	46.68K	+4.08%
Mar 31, 2024	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	3.15%	2.1M	17.14M	0	0
Mar 31, 2024	VANGUARD GROUP INC	4.16%	2.77M	22.63M	32.56K	+1.19%
Mar 31, 2024	OMEGA FUND MANAGEMENT, LLC	4.5%	3M	24.52M	0	0
Mar 31, 2024	FCPM III SERVICES B.V.	7.3%	4.87M	39.76M	-50	0.00%
Mar 31, 2024	PRICE T ROWE ASSOCIATES INC /MD/	9.83%	6.55M	53.51M	699.68K	+11.96%
Mar 31, 2024	UBS GROUP AG	0.55%	367.99K	3.01M	147.56K	+66.94%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	1.47%	977.85K	7.99M	-345.12K	-26.09%
Mar 31, 2024	JEFFERIES FINANCIAL GROUP INC.	1.5%	1M	8.17M	1M	+100.00%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.18%	116.99K	955.78K	0	0
Mar 31, 2024	EMERALD MUTUAL FUND ADVISERS TRUST	0.2%	132.41K	1.08M	-215K	-61.89%
Mar 31, 2024	JACOBS LEVY EQUITY MANAGEMENT, INC	0.2%	133.2K	1.09M	133.2K	+100.00%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	0.69%	461.86K	3.77M	446.84K	+2,973.75%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.77%	513.34K	4.19M	-1.73M	-77.07%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.46%	308.84K	2.52M	194.66K	+170.48%
Mar 31, 2024	WELLINGTON MANAGEMENT GROUP LLP	0.46%	309.78K	2.53M	63.16K	+25.61%
Mar 31, 2024	REDMILE GROUP, LLC	5.6%	3.73M	30.47M	-135.28K	-3.50%
Mar 31, 2024	BLACKROCK INC.	6.92%	4.61M	37.68M	74.07K	+1.63%
Mar 31, 2024	STATE STREET CORP	9.73%	6.49M	53M	1.38M	+26.90%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.05%	34.74K	283.84M	0	0
Mar 31, 2024	DENALI ADVISORS LLC	0.05%	36.3K	296.57K	36.3K	+100.00%
Mar 31, 2024	CREDIT SUISSE AG/	0.06%	37.86K	309.31K	0	0
Mar 31, 2024	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.06%	39.19K	513.35K	-1.03K	-2.57%
Mar 31, 2024	HARBOR CAPITAL ADVISORS, INC.	0.06%	41.72K	341K	9.4K	+29.10%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.06%	43.2K	352.93K	10.33K	+31.44%
Mar 31, 2024	ALPS ADVISORS INC	0.07%	43.29K	353.71K	3.52K	+8.85%
Mar 31, 2024	PRUDENTIAL FINANCIAL INC	0.07%	44.52K	363.73K	-10.13K	-18.54%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.07%	46.73K	381.78K	0	0
Dec 31, 2023	SECTORAL ASSET MANAGEMENT INC	0.46%	305.41K	2.57M	34.36K	+12.67%
Dec 31, 2023	CANADA PENSION PLAN INVESTMENT BOARD	0.48%	319K	2.69M	319K	+100.00%
Dec 31, 2023	EMERALD MUTUAL FUND ADVISERS TRUST	0.52%	347.41K	2.93M	-526.8K	-60.26%
Dec 31, 2023		7.3%	4.87M	41.02M	4.87M	+100.00%
Dec 31, 2023	CLEARBRIDGE INVESTMENTS, LLC	0.41%	270.7K	2.28M	270.7K	+100.00%
Dec 31, 2023	BARCLAYS PLC	0.44%	290.5K	2.45M	172.09K	+145.33%
Dec 31, 2023	WOODLINE PARTNERS LP	0.44%	293.62K	2.48M	0	0
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.18%	116.99K	986.2K	12.76K	+12.24%
Dec 31, 2023	JPMORGAN CHASE & CO	0.46%	305.02K	2.57M	-77.51K	-20.26%
Dec 31, 2023	QUBE RESEARCH & TECHNOLOGIES LTD	0.59%	394.72K	3.33M	394.72K	+100.00%
Dec 31, 2023	GHOST TREE CAPITAL, LLC	0.6%	400K	3.37M	400K	+100.00%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.6%	401.94K	3.39M	23.63K	+6.25%
Dec 31, 2023	RAFFERTY ASSET MANAGEMENT, LLC	0.7%	463.4K	3.91M	276.6K	+148.07%
Dec 31, 2023	NORTHERN TRUST CORP	0.72%	481.83K	4.06M	29.09K	+6.43%
Dec 31, 2023	ARTAL GROUP S.A.	0.75%	500K	4.22M	0	0
Dec 31, 2023	EMERALD ADVISERS, LLC	0.81%	538.84K	4.54M	-513.68K	-48.80%
Dec 31, 2023	FMR LLC	1.24%	825.86K	6.96M	-442.82K	-34.90%
Dec 31, 2023	CAMBER CAPITAL MANAGEMENT LP	1.5%	1M	8.43M	-1M	-50.00%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.72%	1.15M	9.65M	136.77K	+13.56%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	1.99%	1.32M	11.15M	-107.06K	-7.49%
Dec 31, 2023	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	2.72%	1.81M	15.27M	1.81M	+100.00%
Dec 31, 2023	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	3.15%	2.1M	17.69M	0	0
Dec 31, 2023	GOLDMAN SACHS GROUP INC	3.36%	2.24M	18.87M	1.68M	+300.28%
Dec 31, 2023	VANGUARD GROUP INC	4.11%	2.74M	23.08M	141.65K	+5.46%
Dec 31, 2023	OMEGA FUND MANAGEMENT, LLC	4.5%	3M	25.3M	0	0
Dec 31, 2023	VONTOBEL HOLDING LTD.	0.46%	305.41K	2.57M	305.41K	+100.00%
Dec 31, 2023	REDMILE GROUP, LLC	5.8%	3.87M	32.58M	-298.66K	-7.17%
Dec 31, 2023	MORGAN STANLEY	6.67%	4.45M	37.49M	3.98M	+847.51%
Dec 31, 2023	BLACKROCK INC.	6.81%	4.54M	38.26M	580.54K	+14.67%
Dec 31, 2023	STATE STREET CORP	7.67%	5.11M	43.09M	2.74M	+115.62%
Dec 31, 2023	PRICE T ROWE ASSOCIATES INC /MD/	8.78%	5.85M	49.31M	56.05K	+0.97%
Dec 31, 2023	GROUP ONE TRADING, L.P.	0.2%	135.24K	1.14B	89.4K	+195.03%
Dec 31, 2023	DEUTSCHE BANK AG\	0.21%	137.78K	1.16M	119.07K	+636.47%
Dec 31, 2023	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.23%	154.75K	1.3M	24.09K	+18.43%
Dec 31, 2023	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.25%	164.22K	1.38M	39.25K	+31.41%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.25%	168.57K	1.42M	1.14K	+0.68%
Dec 31, 2023	AMUNDI	0.26%	174.45K	1.62M	-407.64K	-70.03%
Dec 31, 2023	BAKER BROS. ADVISORS LP	14.32%	9.55M	80.47M	4.97M	+108.49%
Dec 31, 2023	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.27%	180.44K	1.52M	97.97K	+118.78%
Dec 31, 2023	CITIGROUP INC	0.28%	183.26K	1.54M	103.73K	+130.44%
Dec 31, 2023	NAN FUNG GROUP HOLDINGS LTD	0.28%	184.74K	1.56M	0	0
Dec 31, 2023	BNP PARIBAS ARBITRAGE, SNC	0.29%	196.25K	1.65M	164.49K	+517.90%
Dec 31, 2023	TWO SIGMA ADVISERS, LP	0.3%	202.7K	1.71M	-18.7K	-8.45%
Dec 31, 2023	CITADEL ADVISORS LLC	0.31%	207.54K	1.75M	-989.5K	-82.66%
Dec 31, 2023	UBS GROUP AG	0.33%	220.43K	1.86M	160.48K	+267.73%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.33%	220.65K	1.86M	94.98K	+75.58%
Dec 31, 2023	D. E. SHAW & CO., INC.	0.36%	243.01K	2.05M	162.3K	+201.11%
Dec 31, 2023	JANE STREET GROUP, LLC	0.37%	243.51K	2.05M	243.51K	+100.00%
Dec 31, 2023	WELLINGTON MANAGEMENT GROUP LLP	0.37%	246.62K	2.08M	246.62K	+100.00%
Dec 31, 2023	TD ASSET MANAGEMENT INC	0.4%	267.65K	2.26M	0	0
Dec 31, 2023	ENSIGN PEAK ADVISORS, INC	0.41%	270.01K	2.28M	0	0

Insiders

Among the REPL insiders holding of 2% of the stake in company, OMEGA FUND IV, L.P., , holds the largest shares of 4.76M. STAMPACCHIA OTELLO, , is the second largest REPL insider with ownership of 4.67M shares. COFFIN ROBERT, director, stands third with possession of 1.82M shares of that stake.

Insiders	Designation	Shares Held
OMEGA FUND IV, L.P.		4.76M
STAMPACCHIA OTELLO		4.67M
COFFIN ROBERT	director	1.82M
ASTLEY-SPARKE PHILIP	director	1.41M
RHODES JASON P	director	946K
LOVE COLIN	Chief Operating Officer	777.35K
PATEL SUSHIL	Chief Executive Officer	333.58K
ESPOSITO PAMELA	Chief Business Officer	263.44K
XYNOS KONSTANTINOS	Chief Medical Officer	139.69K
LEWIS TANYA	Chief Dev. Op. Officer	135.29K
HILL EMILY LUISA	Chief Financial Officer	134.37K
FRANCHI JEAN M.	Chief Financial Officer	128.75K
SARCHI CHRISTOPHER	Chief Commercial Officer	123.09K
SCHWENDENMAN ANDREW	Chief Accounting Officer	68.28K
DHINGRA KAPIL	director	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Dec 09, 2025	DHINGRA KAPIL	SALE	10.40	3.17K	32.96K	0
Dec 02, 2025	PATEL SUSHIL	SALE	11.13	10K	111.3K	333.58K
Nov 17, 2025	XYNOS KONSTANTINOS	SALE	9.10	7.25K	65.96K	139.69K
Nov 17, 2025	SARCHI CHRISTOPHER	SALE	9.10	5.21K	47.39K	123.09K
Aug 15, 2025	HILL EMILY LUISA	SALE	5.37	9.15K	49.16K	134.37K
May 20, 2025	HILL EMILY LUISA	SALE	8.05	2.54K	20.41K	143.52K
May 20, 2025	PATEL SUSHIL	SALE	8.06	25.11K	202.35K	343.58K
May 20, 2025	SCHWENDENMAN ANDREW	SALE	8.05	3.29K	26.46K	68.28K
May 20, 2025	XYNOS KONSTANTINOS	SALE	8.06	7.95K	64.09K	146.93K
May 20, 2025	ASTLEY-SPARKE PHILIP	SALE	8.06	32.28K	260.17K	1.41M
May 20, 2025	SARCHI CHRISTOPHER	SALE	8.05	3.75K	30.18K	128.3K
Dec 16, 2024	PATEL SUSHIL	SALE	12.42	10K	124.2K	202.01K
Nov 18, 2024	XYNOS KONSTANTINOS	SALE	10.78	7.25K	78.11K	109.89K
Nov 18, 2024	SARCHI CHRISTOPHER	SALE	10.78	5.21K	56.13K	87.05K
Aug 16, 2024	HILL EMILY LUISA	SALE	10.18	8.94K	90.99K	101.06K
Jun 07, 2024	XYNOS KONSTANTINOS	SALE	7.50	15.88K	119.11K	117.13K
May 16, 2024	XYNOS KONSTANTINOS	SALE	6.47	6.37K	41.19K	133.01K
May 16, 2024	COFFIN ROBERT	SALE	6.47	11.46K	74.17K	1.82M
May 16, 2024	ASTLEY-SPARKE PHILIP	SALE	6.47	37.93K	245.39K	1.49M
May 16, 2024	LOVE COLIN	SALE	6.47	17.62K	113.97K	777.35K
May 16, 2024	SCHWENDENMAN ANDREW	SALE	6.47	2.3K	14.87K	38.24K
May 16, 2024	SARCHI CHRISTOPHER	SALE	6.47	2.22K	14.35K	92.25K
May 16, 2024	PATEL SUSHIL	SALE	6.47	20.19K	130.66K	212.01K
Nov 16, 2023	SARCHI CHRISTOPHER	SALE	10.92	5.26K	57.38K	72.25K
Nov 16, 2023	XYNOS KONSTANTINOS	SALE	10.92	7.31K	79.86K	112.71K
Sep 12, 2023	ESPOSITO PAMELA	SALE	20.00	300	6K	263.44K
Sep 11, 2023	ESPOSITO PAMELA	SALE	20.01	5.36K	107.21K	263.44K
Aug 22, 2023	ESPOSITO PAMELA	SALE	20.01	18.6K	372.19K	263.44K
Aug 11, 2023	ESPOSITO PAMELA	SALE	20.00	1.4K	28K	263.44K
Jul 10, 2023	ESPOSITO PAMELA	SALE	21.12	2.08K	43.87K	263.44K
Jun 13, 2023	LEWIS TANYA	SALE	23.45	817	19.16K	135.29K
Jun 13, 2023	PATEL SUSHIL	SALE	23.44	553	12.96K	148.87K
May 16, 2023	FRANCHI JEAN M.	SALE	18.05	11.35K	204.89K	128.75K
May 16, 2023	XYNOS KONSTANTINOS	SALE	18.05	771	13.92K	120.03K
May 16, 2023	ASTLEY-SPARKE PHILIP	SALE	18.05	17.9K	323.13K	1.53M
May 16, 2023	PATEL SUSHIL	SALE	18.05	15.58K	281.13K	154.57K
May 16, 2023	COFFIN ROBERT	SALE	18.05	7.86K	141.89K	1.83M
May 16, 2023	LOVE COLIN	SALE	18.05	10.78K	194.49K	794.96K
May 16, 2023	ESPOSITO PAMELA	SALE	18.05	5.97K	107.69K	263.44K
May 16, 2023	LEWIS TANYA	SALE	18.05	12.21K	220.34K	148.15K
Dec 09, 2022	ESPOSITO PAMELA	SALE	25.03	15K	375.45K	229.4K
May 16, 2022	LOVE COLIN	SALE	14.59	6.32K	92.27K	765.74K
May 16, 2022	ESPOSITO PAMELA	SALE	14.59	3.51K	51.17K	229.4K
May 16, 2022	FRANCHI JEAN M.	SALE	14.59	3.44K	50.13K	95.1K
May 16, 2022	PATEL SUSHIL	SALE	14.59	10.69K	155.92K	130.15K
May 16, 2022	COFFIN ROBERT	SALE	14.59	5.74K	83.7K	1.8M
May 16, 2022	ASTLEY-SPARKE PHILIP	SALE	14.59	9.63K	140.53K	1.4M
May 16, 2022	LEWIS TANYA	SALE	14.59	5.47K	79.85K	120.36K
Mar 14, 2022	STAMPACCHIA OTELLO	SALE	15.55	38.76K	602.75K	4.67M
Nov 22, 2021	OMEGA FUND IV, L.P.	SALE	34.70	10.16K	352.62K	4.76M
Nov 19, 2021	OMEGA FUND IV, L.P.	SALE	34.80	417	14.51K	4.77M
Nov 18, 2021	OMEGA FUND IV, L.P.	SALE	33.50	2.44K	81.77K	4.81M
Nov 16, 2021	OMEGA FUND IV, L.P.	SALE	33.50	153	5.13K	4.81M
Nov 15, 2021	OMEGA FUND IV, L.P.	SALE	33.66	782	26.32K	4.81M
Nov 12, 2021	OMEGA FUND IV, L.P.	SALE	33.66	23.24K	782.09K	4.81M
Nov 11, 2021	OMEGA FUND IV, L.P.	SALE	33.61	18.28K	614.36K	4.84M
Nov 10, 2021	OMEGA FUND IV, L.P.	SALE	33.50	11	368.5	4.85M
Nov 09, 2021	OMEGA FUND IV, L.P.	SALE	33.73	7.54K	254.22K	4.85M
Nov 08, 2021	OMEGA FUND IV, L.P.	SALE	33.53	3.82K	127.98K	4.86M
Nov 05, 2021	OMEGA FUND IV, L.P.	SALE	33.50	5.79K	193.97K	4.87M
Nov 04, 2021	OMEGA FUND IV, L.P.	SALE	33.58	25.23K	847.06K	4.87M
Oct 18, 2021	LOVE COLIN	SALE	29.58	12.71K	375.99K	745.81K
Oct 15, 2021	LOVE COLIN	SALE	30.31	15.09K	457.35K	758.52K
Sep 23, 2021	OMEGA FUND IV, L.P.	SALE	33.58	12.17K	408.7K	4.9M
Sep 17, 2021	OMEGA FUND IV, L.P.	SALE	33.71	15.47K	521.33K	4.91M
Sep 16, 2021	OMEGA FUND IV, L.P.	SALE	32.55	5.54K	180.23K	5M
Sep 15, 2021	LOVE COLIN	SALE	31.23	30K	936.9K	775.81K
Aug 16, 2021	LOVE COLIN	SALE	29.27	2.7K	79.03K	805.81K
Aug 05, 2021	ESPOSITO PAMELA	SALE	35.09	25.8K	905.32K	210.16K
Aug 04, 2021	ESPOSITO PAMELA	SALE	35.00	4.2K	147K	210.16K
Jul 21, 2021	ESPOSITO PAMELA	SALE	33.17	12.54K	415.89K	210.16K
Jul 20, 2021	ESPOSITO PAMELA	SALE	33.05	4.86K	160.69K	210.16K
Jul 15, 2021	LOVE COLIN	SALE	32.02	30K	960.6K	835.81K
Jul 15, 2021	ESPOSITO PAMELA	SALE	33.37	4.6K	153.5K	210.16K
Jul 02, 2021	COFFIN ROBERT	SALE	40.04	7.81K	312.71K	1.78M
Jun 29, 2021	COFFIN ROBERT	SALE	40.05	22.83K	914.18K	1.78M
Jun 28, 2021	COFFIN ROBERT	SALE	40.04	14.66K	587.11K	1.81M
Jun 15, 2021	LOVE COLIN	SALE	34.53	12.2K	421.27K	865.81K
Apr 15, 2021	LOVE COLIN	SALE	29.98	2.7K	80.95K	895.81K
Mar 15, 2021	LOVE COLIN	SALE	32.67	100	3.27K	886.52K
Feb 16, 2021	LOVE COLIN	SALE	35.84	11.38K	407.86K	916.52K
Feb 08, 2021	OMEGA FUND IV, L.P.	SALE	45.00	5.25K	236.21K	5.14M
Jan 26, 2021	RHODES JASON P	SALE	46.14	5.56K	256.45K	946K
Jan 26, 2021	OMEGA FUND IV, L.P.	SALE	46.04	3.39K	156.21K	5.28M
Jan 22, 2021	OMEGA FUND IV, L.P.	SALE	45.03	3.27K	147.2K	5.31M
Jan 22, 2021	COFFIN ROBERT	SALE	43.99	29.8K	1.31M	1.74M
Jan 19, 2021	LOVE COLIN	SALE	43.25	700	30.28K	953.68K
Jan 19, 2021	ESPOSITO PAMELA	SALE	42.38	5.13K	217.28K	175.99K
Jan 19, 2021	ASTLEY-SPARKE PHILIP	SALE	42.40	7.63K	323.6K	1.26M
Jan 15, 2021	LOVE COLIN	SALE	43.07	12.4K	533.9K	954.38K
Jan 15, 2021	ASTLEY-SPARKE PHILIP	SALE	43.02	9.41K	404.78K	1.26M
Jan 15, 2021	ESPOSITO PAMELA	SALE	43.58	29.27K	1.28M	175.99K
Jan 14, 2021	ESPOSITO PAMELA	SALE	45.02	20K	900.4K	175.99K
Jan 14, 2021	ASTLEY-SPARKE PHILIP	SALE	43.06	100	4.31K	1.28M

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES25.63K4

NET SHARES-25.63K4

SHARES HELD596.35K4

% NET SHARES-104.3%0%

Frequently Asked Questions

Stock Outstanding Shares

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares24.59

Short Percent Of Float46.2

Shares Outstanding78.06M

Shares Float49.98M

Shares Short19.20M

Short Ratio0.91

46.2%

Short % of Float

24.59%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

2% Percentage of Shares held by All Insiders

104.94% Percentage of Shares held by All Institutions

107.09% Percentage of Float held by Institutions

238

Number of Institutions Holding Shares

Institutional Ownership

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	HRT FINANCIAL LP	0.2%	183.59K	1.78M	9.54K	+5.48%
Dec 31, 2025	ROSALIND ADVISORS, INC.	1.53%	1.41M	13.71M	1.41M	+100.00%
Dec 31, 2025	STATE STREET CORP	4.01%	3.69M	35.9M	768.98K	+26.30%
Dec 31, 2025	VANGUARD GROUP INC	4.1%	3.78M	36.7M	296.8K	+8.53%
Dec 31, 2025	BLACKROCK, INC.	6.58%	6.07M	59M	293.74K	+5.09%
Dec 31, 2025	PROFUND ADVISORS LLC	0.06%	52.15K	506.85K	28.48K	+120.31%
Dec 31, 2025	DEUTSCHE BANK AG\	0.06%	53.94K	524.34K	-485.62K	-90.00%
Dec 31, 2025	ACADIAN ASSET MANAGEMENT LLC	0.06%	56.72K	550K	-16.92K	-22.97%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	0.23%	215.33K	2.09M	106.05K	+97.04%
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.27%	251K	2.44M	-1.48M	-85.48%
Dec 31, 2025	JUMP FINANCIAL, LLC	0.32%	296.84K	2.89M	53.08K	+21.77%
Dec 31, 2025	TWO SIGMA INVESTMENTS, LP	0.48%	444.07K	4.32M	286.58K	+181.95%
Dec 31, 2025	JANE STREET GROUP, LLC	0.63%	584.33K	5.68M	55	+0.01%
Dec 31, 2025	BOXER CAPITAL MANAGEMENT, LLC	0.81%	750K	7.29M	-300K	-28.57%
Dec 31, 2025	DIADEMA PARTNERS LP	0.25%	231K	2.25M	231K	+100.00%
Dec 31, 2025	ERSTE ASSET MANAGEMENT GMBH	2.3%	2.12M	20.62M	490K	+30.06%
Dec 31, 2025	D. E. SHAW & CO., INC.	2.79%	2.58M	25.03M	2.17M	+538.18%
Dec 31, 2025	FCPM III SERVICES B.V.	3.05%	2.81M	27.3M	-1.35M	-32.46%
Dec 31, 2025	FMR LLC	3.23%	2.98M	28.98M	1.62M	+119.06%
Dec 31, 2025	RTW INVESTMENTS, LP	7.75%	7.14M	69.4M	744.62K	+11.64%
Dec 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	8.96%	8.26M	80.31M	-44.14K	-0.53%
Dec 31, 2025	BAKER BROS. ADVISORS LP	11.98%	11.05M	107.36M	0	0
Dec 31, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.02%	18.45K	179.29K	0	0
Dec 31, 2025	AXQ CAPITAL, LP	0.02%	19.86K	193.06K	19.86K	+100.00%
Dec 31, 2025	WALLEYE TRADING LLC	0.08%	74.5K	724.14K	36.2K	+94.52%
Dec 31, 2025	DLD ASSET MANAGEMENT, LP	0.12%	112.7K	1.09M	72.7K	+181.75%
Dec 31, 2025	TUDOR INVESTMENT CORP ET AL	0.14%	128.38K	1.25M	107.62K	+518.25%
Dec 31, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.15%	140.91K	1.37M	32.32K	+29.76%
Dec 31, 2025	AMERICAN CENTURY COMPANIES INC	0.16%	148.09K	1.44M	8.35K	+5.98%
Dec 31, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.17%	153.65K	1.49M	153.65K	+100.00%
Dec 31, 2025	QUINN OPPORTUNITY PARTNERS LLC	0.43%	392.92K	3.82M	-257.81K	-39.62%
Dec 31, 2025	HIGHTOWER ADVISORS, LLC	0.02%	20.12K	195.6K	3.99K	+24.76%
Dec 31, 2025	CAPTION MANAGEMENT, LLC	0.25%	228.57K	2.22M	58.57K	+34.45%
Dec 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.44%	405.05K	3.94M	405.05K	+100.00%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.5%	460.7K	4.48M	446.94K	+3,247.65%
Dec 31, 2025	NORTHERN TRUST CORP	0.59%	539.6K	5.24M	-74.59K	-12.14%
Dec 31, 2025	WOODLINE PARTNERS LP	0.62%	570.99K	5.55M	-285K	-33.29%
Dec 31, 2025	NAN FUNG TRINITY (HK) LTD	0.62%	575.53K	5.59M	110K	+23.63%
Dec 31, 2025	INVESCO LTD.	0.67%	613.02K	5.96M	458.71K	+297.29%
Dec 31, 2025	JEFFERIES FINANCIAL GROUP INC.	0.77%	714.23K	6.94M	714.23K	+100.00%
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	0.91%	834.56K	8.11M	-755.18K	-47.50%
Dec 31, 2025	TORONTO DOMINION BANK	2.42%	2.23M	21.67M	857.48K	+62.50%
Dec 31, 2025	CITIGROUP INC	0.02%	20.19K	196.29K	13.07K	+183.35%
Dec 31, 2025	NISA INVESTMENT ADVISORS, LLC	0.02%	20.95K	203.65K	20.06K	+2,243.62%
Dec 31, 2025	BALLENTINE PARTNERS, LLC	0.03%	23.67K	230.02K	1.72K	+7.84%
Dec 31, 2025	DIMENSIONAL FUND ADVISORS LP	1.21%	1.12M	10.88M	-132.14K	-10.56%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.9%	1.75M	17.02M	54.75K	+3.23%
Dec 31, 2025	REDMILE GROUP, LLC	1.19%	1.1M	10.69M	563.94K	+105.25%
Dec 31, 2025	ALLY BRIDGE GROUP (NY) LLC	1.3%	1.2M	11.66M	-2.4M	-66.67%
Dec 31, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	24.7K	240.12K	0	0
Dec 31, 2025	DYNAMIC TECHNOLOGY LAB PRIVATE LTD	0.03%	25.91K	252K	5.78K	+28.73%
Dec 31, 2025	NUVEEN, LLC	0.06%	57.61K	560.01M	0	0
Dec 31, 2025	SQUAREPOINT OPS LLC	0.07%	67.27K	653.87K	-4.54K	-6.32%
Dec 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	1.35%	1.24M	12.07M	262.43K	+26.81%
Dec 31, 2025	COMMODORE CAPITAL LP	1.55%	1.43M	13.85M	1.43M	+100.00%
Dec 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.96%	1.81M	17.57M	1.81M	+100.00%
Dec 31, 2025	TEMA ETFS LLC	0.06%	51.28K	498.46K	8.32K	+19.35%
Dec 31, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.05%	44.05K	451.46K	1.27K	+2.97%
Dec 31, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	34.33K	333.67K	-6.21K	-15.32%
Dec 31, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.03%	32.09K	311.94K	19.65K	+157.82%
Dec 31, 2025	GSA CAPITAL PARTNERS LLP	0.03%	29.15K	283K	9.86K	+51.13%
Dec 31, 2025	QUEST PARTNERS LLC	0.03%	28.08K	272.94K	3.05K	+12.19%
Dec 31, 2025	SG AMERICAS SECURITIES, LLC	0.08%	71.96K	699K	-26.78K	-27.12%
Dec 31, 2025	WALLEYE CAPITAL LLC	0.09%	86.2K	837.86K	26K	+43.19%
Dec 31, 2025	JPMORGAN CHASE & CO	1%	925.17K	8.99M	887.16K	+2,333.64%
Dec 31, 2025	MORGAN STANLEY	0.88%	814.89K	7.92M	-560.63K	-40.76%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	0.71%	658.1K	6.4M	-476.66K	-42.01%
Dec 31, 2025	UBS GROUP AG	0.66%	604.31K	5.87M	-297.32K	-32.98%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.64%	587.89K	5.71M	72.49K	+14.06%
Dec 31, 2025	BARCLAYS PLC	0.32%	292.19K	2.84M	-163.68K	-35.90%
Dec 31, 2025	TD ASSET MANAGEMENT INC	0.29%	266.48K	2.59M	-17.57K	-6.18%
Dec 31, 2025	CITADEL ADVISORS LLC	0.27%	250.2K	2.43M	-4.8K	-1.88%
Dec 31, 2025	OMEGA FUND MANAGEMENT, LLC	0.27%	248.67K	2.42M	0	0
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.23%	209.22K	2.03M	7.92K	+3.93%
Dec 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.23%	208.67K	2.03M	-18.35K	-8.08%
Dec 31, 2025	RHUMBLINE ADVISERS	0.1%	89.31K	868.09M	-10K	-10.07%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.1%	90.72K	881.84K	-64.66K	-41.61%
Dec 31, 2025	MARSHALL WACE, LLP	0.1%	93.59K	909.65K	93.59K	+100.00%
Dec 31, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.19%	178.91K	1.75M	-38.68K	-17.77%
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.17%	157.5K	659.92K	135.08K	+602.46%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.17%	155.38K	651.04K	-12.63K	-7.51%
Sep 30, 2025	HRT FINANCIAL LP	0.19%	174.05K	729K	82.88K	+90.90%
Sep 30, 2025	RAYMOND JAMES FINANCIAL INC	0.2%	186.99K	783.51K	179.58K	+2,422.17%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.22%	201.31K	843.48K	-5.26K	-2.54%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.24%	1.13M	4.75M	17.42K	+1.56%
Sep 30, 2025	ERSTE ASSET MANAGEMENT GMBH	1.78%	1.63M	7.07M	1.62M	+13,597.48%
Sep 30, 2025	DIADEMA PARTNERS LP	0.67%	612.3K	2.57M	612.3K	+100.00%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.56%	515.4K	2.16M	-37.76K	-6.83%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	1.89%	1.73M	7.24M	1.61M	+1,381.41%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	2.87%	2.63M	11.01M	2.2M	+507.44%
Sep 30, 2025	BRAIDWELL LP	3.01%	2.75M	11.52M	2.33M	+550.31%
Sep 30, 2025	STATE STREET CORP	3.2%	2.92M	12.25M	471.44K	+19.22%
Sep 30, 2025	TANG CAPITAL MANAGEMENT LLC	3.72%	3.4M	14.25M	200K	+6.25%
Sep 30, 2025	ALLY BRIDGE GROUP (NY) LLC	3.93%	3.6M	15.08M	3.6M	+100.00%
Sep 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	3.97%	3.63M	15.21M	2.92M	+409.43%
Sep 30, 2025	FCPM III SERVICES B.V.	4.54%	4.16M	17.42M	248.67K	+6.36%
Sep 30, 2025	RTW INVESTMENTS, LP	6.99%	6.4M	26.8M	4.33M	+209.72%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	9.08%	8.31M	34.81M	-2.51M	-23.23%
Sep 30, 2025	BAKER BROS. ADVISORS LP	12.07%	11.05M	46.28M	0	0
Sep 30, 2025	OMEGA FUND MANAGEMENT, LLC	0.27%	248.67K	1.04M	-1.73M	-87.41%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.31%	284.05K	1.19M	-43.4K	-13.25%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.33%	300K	1.26M	225K	+300.00%
Sep 30, 2025	JANE STREET GROUP, LLC	0.37%	340.7K	1.43M	3.9K	+1.16%
Sep 30, 2025	CITADEL ADVISORS LLC	0.28%	255K	1.07M	93.4K	+57.80%
Sep 30, 2025	NAN FUNG TRINITY (HK) LTD	0.51%	465.53K	1.95M	0	0
Sep 30, 2025	DYNAMIC TECHNOLOGY LAB PRIVATE LTD	0.02%	20.12K	85K	20.12K	+100.00%
Sep 30, 2025	BALLENTINE PARTNERS, LLC	0.02%	21.94K	91.95K	21.94K	+100.00%
Sep 30, 2025	PROFUND ADVISORS LLC	0.03%	23.67K	99.17K	6.65K	+39.05%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	24.7K	103.51K	-11.16K	-31.12%
Sep 30, 2025	QUEST PARTNERS LLC	0.03%	25.03K	104.88K	15.17K	+153.93%
Sep 30, 2025	TCG ADVISORY SERVICES, LLC	0.03%	25.37K	106.29K	0	0
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.03%	26.77K	112.15K	-26.43K	-49.68%
Sep 30, 2025	GROUP ONE TRADING, L.P.	0.03%	28.86K	120.92M	9.14K	+46.33%
Sep 30, 2025	ALPS ADVISORS INC	0.04%	37.29K	156.23K	-4.32K	-10.37%
Sep 30, 2025	JPMORGAN CHASE & CO	0.04%	38.02K	159.29K	1.71K	+4.72%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	40.54K	169.85K	-60	-0.15%
Sep 30, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.05%	42.77K	179.22K	-648	-1.49%
Sep 30, 2025	TEMA ETFS LLC	0.05%	42.97K	180.03K	2.06K	+5.04%
Sep 30, 2025	NEOS INVESTMENT MANAGEMENT LLC	0.05%	42.97K	180.03K	2.06K	+5.04%
Sep 30, 2025	DIAMETRIC CAPITAL, LP	0.05%	50K	209.5K	50K	+100.00%
Sep 30, 2025	NUVEEN, LLC	0.06%	57.61K	241.4K	-69.71K	-54.75%
Sep 30, 2025	NAN FUNG GROUP HOLDINGS LTD	0.07%	63.72K	266.98K	0	0
Sep 30, 2025	SWISS NATIONAL BANK	0.08%	73.5K	307.97K	0	0
Sep 30, 2025	ACADIAN ASSET MANAGEMENT LLC	0.08%	73.64K	306K	73.64K	+100.00%
Sep 30, 2025	FRANKLIN RESOURCES INC	0.09%	81.23K	340.37K	81.23K	+100.00%
Sep 30, 2025	PANAGORA ASSET MANAGEMENT INC	0.09%	83.25K	348.8K	-17.47K	-17.35%
Sep 30, 2025	SG AMERICAS SECURITIES, LLC	0.11%	98.73K	414K	88.53K	+868.05%
Sep 30, 2025	RHUMBLINE ADVISERS	0.11%	99.32K	416.12K	-2.69K	-2.64%
Sep 30, 2025	HAP TRADING, LLC	0.11%	100K	10M	100K	+100.00%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.12%	108.59K	455K	29.06K	+36.54%
Sep 30, 2025	Y-INTERCEPT (HONG KONG) LTD	0.13%	121.4K	508.65K	121.4K	+100.00%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.15%	139.74K	585.49K	6.63K	+4.98%
Sep 30, 2025	VANGUARD GROUP INC	3.8%	3.48M	14.58M	9.71K	+0.28%
Sep 30, 2025	BLACKROCK, INC.	6.31%	5.78M	24.2M	45.51K	+0.79%
Sep 30, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.24%	217.59K	911.69K	-51.53K	-19.15%
Sep 30, 2025	DLD ASSET MANAGEMENT, LP	0.32%	292.6K	1.22M	292.6K	+100.00%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.25%	227.02K	951.2K	-717.49K	-75.96%
Sep 30, 2025	JUMP FINANCIAL, LLC	0.27%	243.77K	1.02M	243.77K	+100.00%
Sep 30, 2025	STATE OF WISCONSIN INVESTMENT BOARD	0.28%	258.96K	1.09M	184.18K	+246.29%
Sep 30, 2025	D. E. SHAW & CO., INC.	0.44%	403.5K	1.69M	-103.1K	-20.35%
Sep 30, 2025	BARCLAYS PLC	0.5%	455.86K	1.91M	83.75K	+22.51%
Sep 30, 2025	REDMILE GROUP, LLC	0.59%	535.82K	2.25M	-4.13M	-88.51%
Sep 30, 2025	DEUTSCHE BANK AG\	0.59%	539.57K	2.26M	6.56K	+1.23%
Sep 30, 2025	NORTHERN TRUST CORP	0.67%	614.19K	2.57M	27.43K	+4.67%
Sep 30, 2025	CAPTION MANAGEMENT, LLC	0.93%	852.2K	3.57M	59.8K	+7.55%
Sep 30, 2025	QUINN OPPORTUNITY PARTNERS LLC	0.71%	650.72K	2.73M	650.72K	+100.00%
Sep 30, 2025	UBS GROUP AG	0.99%	901.63K	3.78M	658.23K	+270.44%
Sep 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	1.07%	978.89K	4.1M	968.49K	+9,312.44%
Sep 30, 2025	BOXER CAPITAL MANAGEMENT, LLC	1.15%	1.05M	4.4M	-1.16M	-52.52%
Sep 30, 2025	TORONTO DOMINION BANK	1.5%	1.37M	5.75M	1.37M	+100.00%
Sep 30, 2025	WOODLINE PARTNERS LP	0.94%	855.99K	3.59M	0	0
Sep 30, 2025	CENTIVA CAPITAL, LP	0.27%	248.8K	1.04M	98.8K	+65.87%
Sep 30, 2025	MORGAN STANLEY	1.5%	1.38M	5.76M	453.86K	+49.24%
Sep 30, 2025	READYSTATE ASSET MANAGEMENT LP	2.86%	2.62M	10.98M	2.43M	+1,296.23%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	1.37%	1.25M	5.24M	86.05K	+7.38%
Sep 30, 2025	FMR LLC	1.49%	1.36M	5.7M	969.42K	+247.52%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.85%	1.7M	7.11M	71.4K	+4.40%
Sep 30, 2025	SIMPLEX TRADING, LLC	0.16%	150.45K	630K	111.9K	+290.30%
Sep 30, 2025	INVESCO LTD.	0.17%	154.3K	646.52K	34.97K	+29.31%
Jun 30, 2025	BRAIDWELL LP	0.46%	422.89K	3.93M	-1.04M	-71.07%
Jun 30, 2025	TANG CAPITAL MANAGEMENT LLC	3.5%	3.2M	29.73M	300K	+10.34%
Jun 30, 2025	ENSIGN PEAK ADVISORS, INC	0.35%	322.4K	3M	0	0
Jun 30, 2025	PRELUDE CAPITAL MANAGEMENT, LLC	0.14%	123.78K	1.15M	41.22K	+49.92%
Jun 30, 2025	STATE OF WISCONSIN INVESTMENT BOARD	0.08%	74.78K	694.72K	27.08K	+56.76%
Jun 30, 2025	BAKER BROS. ADVISORS LP	12.07%	11.05M	102.61M	0	0
Jun 30, 2025	RTW INVESTMENTS, LP	2.26%	2.07M	19.18M	0	0
Jun 30, 2025	SOFINNOVA INVESTMENTS, INC.	1.64%	1.5M	13.94M	1.5M	+100.00%
Jun 30, 2025	MORGAN STANLEY	1.01%	921.66K	8.56B	-6.6K	-0.71%
Jun 30, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.98%	896.71K	8.33M	-53.69K	-5.65%
Jun 30, 2025	WOODLINE PARTNERS LP	0.94%	855.99K	7.95M	750	+0.09%
Jun 30, 2025	ALLY BRIDGE GROUP (NY) LLC	0.58%	528.49K	4.91M	528.49K	+100.00%
Jun 30, 2025	ARTISAN PARTNERS LIMITED PARTNERSHIP	0.56%	511.37K	4.75M	-53.7K	-9.50%
Jun 30, 2025	TD ASSET MANAGEMENT INC	0.36%	327.45K	3.04M	51.6K	+18.71%
Jun 30, 2025	SECTORAL ASSET MANAGEMENT INC	0.25%	231.65K	2.15M	231.65K	+100.00%
Jun 30, 2025	MOODY ALDRICH PARTNERS LLC	0.21%	194.45K	1.81M	-2.93K	-1.49%
Jun 30, 2025	READYSTATE ASSET MANAGEMENT LP	0.21%	187.72K	1.74M	187.72K	+100.00%
Jun 30, 2025	VELAN CAPITAL INVESTMENT MANAGEMENT LP	0.2%	183.08K	1.7M	1K	+0.55%
Jun 30, 2025	CANDRIAM S.C.A.	0.19%	171.53K	1.59M	171.53K	+100.00%
Jun 30, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.17%	157.55K	1.46M	157.55K	+100.00%
Jun 30, 2025	CENTIVA CAPITAL, LP	0.16%	150K	1.39M	150K	+100.00%
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	0.15%	133.11K	1.24M	-132	-0.10%
Jun 30, 2025	TREXQUANT INVESTMENT LP	0.14%	131.49K	1.22M	-21.05K	-13.80%
Jun 30, 2025	SATURN V CAPITAL MANAGEMENT LLC	0.14%	128.92K	1.2M	128.92K	+100.00%
Jun 30, 2025	UBS OCONNOR LLC	0.12%	114.08K	1.06M	-136.34K	-54.44%
Jun 30, 2025	HRT FINANCIAL LP	0.1%	91.18K	847K	91.18K	+100.00%
Jun 30, 2025	ALGERT GLOBAL LLC	0.09%	79.37K	737K	33.55K	+73.22%
Jun 30, 2025	ECOR1 CAPITAL, LLC	0.93%	850.34K	7.9M	0	0
Jun 30, 2025	BLACKROCK, INC.	6.26%	5.73M	53.24M	-331.51K	-5.47%
Jun 30, 2025	REDMILE GROUP, LLC	5.1%	4.66M	43.34M	-233.74K	-4.77%
Jun 30, 2025	J. GOLDMAN & CO LP	0.07%	67.6K	628K	67.6K	+100.00%
Jun 30, 2025	ENCOMPASS MORE ASSET MANAGEMENT	0.07%	66.73K	619.92K	66.73K	+100.00%
Jun 30, 2025	NAN FUNG GROUP HOLDINGS LTD	0.07%	63.72K	591.95K	-350.53K	-84.62%
Jun 30, 2025	XTX TOPCO LTD	0.07%	62.79K	583.36K	62.79K	+100.00%
Jun 30, 2025	BREVAN HOWARD CAPITAL MANAGEMENT LP	0.06%	58.24K	541.07K	58.24K	+100.00%
Jun 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.06%	53.81K	499.85K	1.03K	+1.94%
Jun 30, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.05%	43.42K	403.39K	43.42K	+100.00%
Jun 30, 2025	ALPS ADVISORS INC	0.05%	41.6K	386.48K	-14.73K	-26.14%
Jun 30, 2025	NEOS INVESTMENT MANAGEMENT LLC	0.04%	40.91K	380.02K	3.38K	+9.02%
Jun 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.04%	35.86K	333.18K	-4.85K	-11.91%
Jun 30, 2025		0.36%	330.34K	3.07M	-25.3K	-7.11%
Jun 30, 2025	MARSHALL WACE, LLP	2.04%	1.87M	17.34M	-621.16K	-24.97%
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.78%	712.54K	6.62M	616.57K	+642.41%
Jun 30, 2025	D. E. SHAW & CO., INC.	0.55%	506.6K	4.71B	-289.98K	-36.40%
Jun 30, 2025	CANTOR FITZGERALD, L. P.	0.22%	200K	1.86M	200K	+100.00%
Jun 30, 2025	FISHER ASSET MANAGEMENT, LLC	0.09%	81.95K	761.31K	0	0
Jun 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.09%	79.53K	738.84K	923	+1.17%
Jun 30, 2025	STATE STREET CORP	2.68%	2.45M	22.79M	54.64K	+2.28%
Jun 30, 2025	OMEGA FUND MANAGEMENT, LLC	2.16%	1.98M	18.35M	0	0
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.77%	1.62M	15.09M	-48.72K	-2.91%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	1.27%	1.17M	10.83M	215.58K	+22.70%
Jun 30, 2025	BIOIMPACT CAPITAL LLC	1.08%	983.78K	9.14M	-3.26K	-0.33%
Jun 30, 2025	BARCLAYS PLC	0.41%	372.11K	3.46M	217.31K	+140.39%
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.26%	234.81K	2.18M	-223.87K	-48.81%
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.25%	229.3K	2.13M	194.6K	+560.81%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.23%	206.56K	1.92M	17.39K	+9.19%
Jun 30, 2025	FCPM III SERVICES B.V.	4.27%	3.91M	36.32M	0	0
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	1.03%	944.51K	8.77M	8.15K	+0.87%
Jun 30, 2025	ROSALIND ADVISORS, INC.	0.98%	900K	8.36M	50K	+5.88%
Jun 30, 2025	CAPTION MANAGEMENT, LLC	0.49%	445.6K	4.14M	445.6K	+100.00%
Jun 30, 2025	NORTHERN TRUST CORP	0.64%	586.77K	5.45M	-46.23K	-7.30%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.6%	553.16K	5.14M	1.12K	+0.20%
Jun 30, 2025	DEUTSCHE BANK AG\	0.58%	533.01K	4.95M	-30.69K	-5.45%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.55%	505.11K	4.69M	143.83K	+39.81%
Jun 30, 2025	NAN FUNG TRINITY (HK) LTD	0.51%	465.53K	4.32M	465.53K	+100.00%
Jun 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.47%	432.65K	4.02M	99.42K	+29.83%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.45%	412.7K	3.83M	412.7K	+100.00%
Jun 30, 2025	FMR LLC	0.43%	391.66K	3.64M	-11.71K	-2.90%
Jun 30, 2025	JANE STREET GROUP, LLC	0.37%	336.8K	3.13M	336.8K	+100.00%
Jun 30, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.29%	269.12K	2.5M	61.04K	+29.34%
Jun 30, 2025	UBS GROUP AG	0.27%	243.4K	2.26M	95.09K	+64.12%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	11.82%	10.82M	100.51M	-34.62K	-0.32%
Jun 30, 2025	VANGUARD GROUP INC	3.79%	3.47M	32.23M	-363.35K	-9.48%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	1.22%	1.12M	10.38B	427.16K	+61.89%
Jun 30, 2025	CITADEL ADVISORS LLC	0.3%	277.47K	2.58B	254.72K	+1,119.40%
Jun 30, 2025	BOXER CAPITAL MANAGEMENT, LLC	2.42%	2.21M	20.54M	415K	+23.10%
Jun 30, 2025	CATALIO CAPITAL MANAGEMENT, LP	0.36%	330.34K	3.07M	-25.3K	-7.11%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	1.47%	1.22M	11.93M	33.57K	+2.82%
Mar 31, 2025	BRAIDWELL LP	1.75%	1.46M	14.25M	-15.28K	-1.03%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	2%	1.67M	16.31M	243.1K	+17.00%
Mar 31, 2025	OMEGA FUND MANAGEMENT, LLC	2.37%	1.98M	19.26M	0	0
Mar 31, 2025	VANGUARD GROUP INC	4.59%	3.83M	37.37M	237.19K	+6.60%
Mar 31, 2025	REDMILE GROUP, LLC	5.87%	4.9M	47.76M	-7K	-0.14%
Mar 31, 2025	MARSHALL WACE, LLP	2.98%	2.49M	24.25M	1.59M	+177.59%
Mar 31, 2025	TANG CAPITAL MANAGEMENT LLC	3.47%	2.9M	28.28M	200K	+7.41%
Mar 31, 2025	STATE STREET CORP	2.87%	2.4M	23.38M	194K	+8.80%
Mar 31, 2025	SOFINNOVA INVESTMENTS, INC.	2.97%	2.48M	24.18M	-669.58K	-21.26%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	13%	10.85M	105.83M	-109.05K	-0.99%
Mar 31, 2025	BAKER BROS. ADVISORS LP	13.23%	11.05M	107.69M	0	0
Mar 31, 2025	INVESCO LTD.	0.39%	322.34K	3.14M	234.34K	+266.27%
Mar 31, 2025	ROSALIND ADVISORS, INC.	1.02%	850K	8.29M	590K	+226.92%
Mar 31, 2025	NORTHERN TRUST CORP	0.76%	633K	6.17M	43.36K	+7.35%
Mar 31, 2025	ARTISAN PARTNERS LIMITED PARTNERSHIP	0.68%	565.08K	5.51M	-45.94K	-7.52%
Mar 31, 2025	DEUTSCHE BANK AG\	0.68%	563.7K	5.5M	2.14K	+0.38%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.66%	552.05K	5.38M	43.65K	+8.59%
Mar 31, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.55%	458.67K	4.47M	295.37K	+180.88%
Mar 31, 2025	NAN FUNG GROUP HOLDINGS LTD	0.5%	414.25K	4.04M	92.5K	+28.75%
Mar 31, 2025	FMR LLC	0.48%	403.37K	3.93M	56.09K	+16.15%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.43%	361.28K	3.52M	336.85K	+1,379.25%
Mar 31, 2025		0.43%	355.64K	3.47M	355.64K	+100.00%
Mar 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.4%	333.24K	3.25M	333.24K	+100.00%
Mar 31, 2025	ENSIGN PEAK ADVISORS, INC	0.39%	322.4K	3.14M	322.4K	+100.00%
Mar 31, 2025	EXOME ASSET MANAGEMENT LLC	0.35%	294.85K	2.87M	240.11K	+438.65%
Mar 31, 2025	TD ASSET MANAGEMENT INC	0.33%	275.85K	2.69M	-18.45K	-6.27%
Mar 31, 2025	JANE STREET GROUP, LLC	0.32%	264.9K	2.58M	-51.39K	-16.25%
Mar 31, 2025	UBS OCONNOR LLC	0.3%	250.42K	2.44M	8.85K	+3.66%
Mar 31, 2025	JPMORGAN CHASE & CO	0.26%	220.59K	2.15M	-266.02K	-54.67%
Mar 31, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.25%	208.08K	2.03M	14.07K	+7.25%
Mar 31, 2025	MOODY ALDRICH PARTNERS LLC	0.24%	197.39K	1.92M	197.39K	+100.00%
Mar 31, 2025	PDT PARTNERS, LLC	0.19%	158.76K	1.55M	-34	-0.02%
Mar 31, 2025	WELLS FARGO & COMPANY/MN	0.19%	158.28K	1.54M	80.91K	+104.57%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.19%	156.24K	1.52M	-700	-0.45%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.19%	155.9K	1.52M	110.81K	+245.71%
Mar 31, 2025	BARCLAYS PLC	0.19%	154.8K	1.51M	-12.53K	-7.49%
Mar 31, 2025	WOODLINE PARTNERS LP	1.02%	855.24K	8.34M	929	+0.11%
Mar 31, 2025	MORGAN STANLEY	1.11%	928.26K	9.05M	-119.37K	-11.39%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	1.12%	936.36K	9.13M	-160.38K	-14.62%
Mar 31, 2025	RTW INVESTMENTS, LP	2.47%	2.07M	20.13M	0	0
Mar 31, 2025	D. E. SHAW & CO., INC.	0.95%	796.58K	7.77M	-176K	-18.10%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.83%	690.17K	6.73M	119.15K	+20.87%
Mar 31, 2025	BLACKROCK, INC.	7.26%	6.06M	59.1M	495.5K	+8.90%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.23%	189.18K	1.84M	14.66K	+8.40%
Mar 31, 2025	VELAN CAPITAL INVESTMENT MANAGEMENT LP	0.22%	182.08K	1.78M	716	+0.39%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	1.14%	949.87K	9.27M	171.71K	+22.07%
Mar 31, 2025	PARKMAN HEALTHCARE PARTNERS LLC	1.14%	950.4K	9.27M	80.64K	+9.27%
Mar 31, 2025	BIOIMPACT CAPITAL LLC	1.18%	987.04K	9.62M	37.04K	+3.90%
Mar 31, 2024	RHUMBLINE ADVISERS	0.12%	79.19K	646.98K	2.03K	+2.63%
Mar 31, 2024	GHOST TREE CAPITAL, LLC	0.98%	650K	5.31M	250K	+62.50%
Mar 31, 2024	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.2%	802.98K	6.56M	-1.01M	-55.68%
Mar 31, 2024	D. E. SHAW & CO., INC.	1.5%	997.79K	8.15M	754.78K	+310.60%
Mar 31, 2024	MORGAN STANLEY	3.98%	2.65M	21.68M	-1.79M	-40.32%
Mar 31, 2024	CAMBER CAPITAL MANAGEMENT LP	4.13%	2.75M	22.47M	1.75M	+175.00%
Mar 31, 2024	PANAGORA ASSET MANAGEMENT INC	0.08%	56.61K	462.5K	56.61K	+100.00%
Mar 31, 2024	BNP PARIBAS ARBITRAGE, SNC	0.09%	58.73K	479.78K	-137.53K	-70.08%
Mar 31, 2024	ENTROPY TECHNOLOGIES, LP	0.09%	59.33K	484.69K	9.18K	+18.31%
Mar 31, 2024	LOS ANGELES CAPITAL MANAGEMENT LLC	0.1%	66.41K	542.53K	30.2K	+83.43%
Mar 31, 2024	SWISS NATIONAL BANK	0.1%	69.8K	570.27K	0	0
Mar 31, 2024	FISHER ASSET MANAGEMENT, LLC	0.12%	77.66K	634.51K	0	0
Mar 31, 2024	DEUTSCHE BANK AG\	0.78%	522.05K	4.27M	384.27K	+278.90%
Mar 31, 2024	ALGERT GLOBAL LLC	0.12%	79.69K	651K	15.72K	+24.57%
Mar 31, 2024	INVESCO LTD.	0.13%	86.66K	707.99K	64.44K	+290.00%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.11%	74.4K	607.85K	74.4K	+100.00%
Mar 31, 2024	PROFUND ADVISORS LLC	0.15%	98.32K	803.25M	24.08K	+32.44%
Mar 31, 2024	TREXQUANT INVESTMENT LP	0.15%	100.43K	820.55K	100.43K	+100.00%
Mar 31, 2024	WOODLINE PARTNERS LP	0.44%	293.62K	2.4M	0	0
Mar 31, 2024	BAKER BROS. ADVISORS LP	14.32%	9.55M	77.99M	0	0
Mar 31, 2024	BARCLAYS PLC	0.16%	108.53K	885K	-181.97K	-62.64%
Mar 31, 2024	ACADIAN ASSET MANAGEMENT LLC	0.17%	113.65K	927K	113.65K	+100.00%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.22%	148.17K	1.21M	-6.58K	-4.25%
Mar 31, 2024	JANE STREET GROUP, LLC	0.24%	157.82K	1.29M	-85.69K	-35.19%
Mar 31, 2024	SCHONFELD STRATEGIC ADVISORS LLC	0.24%	158.29K	1.29M	115.9K	+273.38%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.24%	161.05K	1.32M	127.2K	+375.74%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.24%	162.76K	1.33M	-5.82K	-3.45%
Mar 31, 2024	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.26%	171.02K	1.4M	6.79K	+4.14%
Mar 31, 2024	NAN FUNG GROUP HOLDINGS LTD	0.31%	204.94K	1.67M	20.2K	+10.93%
Mar 31, 2024	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.32%	212.65K	1.74M	32.21K	+17.85%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.33%	221.22K	1.81M	-173.49K	-43.95%
Mar 31, 2024	TWO SIGMA ADVISERS, LP	0.33%	222.6K	1.82M	19.9K	+9.82%
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.36%	238.85K	1.95M	-28.8K	-10.76%
Mar 31, 2024	AMUNDI	0.37%	248.08K	1.73M	73.63K	+42.21%
Mar 31, 2024	JPMORGAN CHASE & CO	0.41%	272.13K	2.22M	-32.89K	-10.78%
Mar 31, 2024	CLEARBRIDGE INVESTMENTS, LLC	0.42%	277.97K	2.27M	7.27K	+2.69%
Mar 31, 2024	FMR LLC	0.43%	286.48K	2.34M	-539.38K	-65.31%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.59%	390.03K	3.19M	169.38K	+76.77%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.63%	418.66K	3.42M	16.72K	+4.16%
Mar 31, 2024	NORTHERN TRUST CORP	0.73%	483.64K	3.95M	1.81K	+0.38%
Mar 31, 2024	EMERALD ADVISERS, LLC	0.74%	492.22K	4.02M	-46.62K	-8.65%
Mar 31, 2024	CITIGROUP INC	0.81%	542.49K	4.43M	359.23K	+196.02%
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	0.96%	642.08K	5.25M	178.68K	+38.56%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	1.79%	1.19M	9.74M	46.68K	+4.08%
Mar 31, 2024	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	3.15%	2.1M	17.14M	0	0
Mar 31, 2024	VANGUARD GROUP INC	4.16%	2.77M	22.63M	32.56K	+1.19%
Mar 31, 2024	OMEGA FUND MANAGEMENT, LLC	4.5%	3M	24.52M	0	0
Mar 31, 2024	FCPM III SERVICES B.V.	7.3%	4.87M	39.76M	-50	0.00%
Mar 31, 2024	PRICE T ROWE ASSOCIATES INC /MD/	9.83%	6.55M	53.51M	699.68K	+11.96%
Mar 31, 2024	UBS GROUP AG	0.55%	367.99K	3.01M	147.56K	+66.94%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	1.47%	977.85K	7.99M	-345.12K	-26.09%
Mar 31, 2024	JEFFERIES FINANCIAL GROUP INC.	1.5%	1M	8.17M	1M	+100.00%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.18%	116.99K	955.78K	0	0
Mar 31, 2024	EMERALD MUTUAL FUND ADVISERS TRUST	0.2%	132.41K	1.08M	-215K	-61.89%
Mar 31, 2024	JACOBS LEVY EQUITY MANAGEMENT, INC	0.2%	133.2K	1.09M	133.2K	+100.00%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	0.69%	461.86K	3.77M	446.84K	+2,973.75%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.77%	513.34K	4.19M	-1.73M	-77.07%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.46%	308.84K	2.52M	194.66K	+170.48%
Mar 31, 2024	WELLINGTON MANAGEMENT GROUP LLP	0.46%	309.78K	2.53M	63.16K	+25.61%
Mar 31, 2024	REDMILE GROUP, LLC	5.6%	3.73M	30.47M	-135.28K	-3.50%
Mar 31, 2024	BLACKROCK INC.	6.92%	4.61M	37.68M	74.07K	+1.63%
Mar 31, 2024	STATE STREET CORP	9.73%	6.49M	53M	1.38M	+26.90%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.05%	34.74K	283.84M	0	0
Mar 31, 2024	DENALI ADVISORS LLC	0.05%	36.3K	296.57K	36.3K	+100.00%
Mar 31, 2024	CREDIT SUISSE AG/	0.06%	37.86K	309.31K	0	0
Mar 31, 2024	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.06%	39.19K	513.35K	-1.03K	-2.57%
Mar 31, 2024	HARBOR CAPITAL ADVISORS, INC.	0.06%	41.72K	341K	9.4K	+29.10%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.06%	43.2K	352.93K	10.33K	+31.44%
Mar 31, 2024	ALPS ADVISORS INC	0.07%	43.29K	353.71K	3.52K	+8.85%
Mar 31, 2024	PRUDENTIAL FINANCIAL INC	0.07%	44.52K	363.73K	-10.13K	-18.54%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.07%	46.73K	381.78K	0	0
Dec 31, 2023	SECTORAL ASSET MANAGEMENT INC	0.46%	305.41K	2.57M	34.36K	+12.67%
Dec 31, 2023	CANADA PENSION PLAN INVESTMENT BOARD	0.48%	319K	2.69M	319K	+100.00%
Dec 31, 2023	EMERALD MUTUAL FUND ADVISERS TRUST	0.52%	347.41K	2.93M	-526.8K	-60.26%
Dec 31, 2023		7.3%	4.87M	41.02M	4.87M	+100.00%
Dec 31, 2023	CLEARBRIDGE INVESTMENTS, LLC	0.41%	270.7K	2.28M	270.7K	+100.00%
Dec 31, 2023	BARCLAYS PLC	0.44%	290.5K	2.45M	172.09K	+145.33%
Dec 31, 2023	WOODLINE PARTNERS LP	0.44%	293.62K	2.48M	0	0
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.18%	116.99K	986.2K	12.76K	+12.24%
Dec 31, 2023	JPMORGAN CHASE & CO	0.46%	305.02K	2.57M	-77.51K	-20.26%
Dec 31, 2023	QUBE RESEARCH & TECHNOLOGIES LTD	0.59%	394.72K	3.33M	394.72K	+100.00%
Dec 31, 2023	GHOST TREE CAPITAL, LLC	0.6%	400K	3.37M	400K	+100.00%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.6%	401.94K	3.39M	23.63K	+6.25%
Dec 31, 2023	RAFFERTY ASSET MANAGEMENT, LLC	0.7%	463.4K	3.91M	276.6K	+148.07%
Dec 31, 2023	NORTHERN TRUST CORP	0.72%	481.83K	4.06M	29.09K	+6.43%
Dec 31, 2023	ARTAL GROUP S.A.	0.75%	500K	4.22M	0	0
Dec 31, 2023	EMERALD ADVISERS, LLC	0.81%	538.84K	4.54M	-513.68K	-48.80%
Dec 31, 2023	FMR LLC	1.24%	825.86K	6.96M	-442.82K	-34.90%
Dec 31, 2023	CAMBER CAPITAL MANAGEMENT LP	1.5%	1M	8.43M	-1M	-50.00%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.72%	1.15M	9.65M	136.77K	+13.56%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	1.99%	1.32M	11.15M	-107.06K	-7.49%
Dec 31, 2023	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	2.72%	1.81M	15.27M	1.81M	+100.00%
Dec 31, 2023	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	3.15%	2.1M	17.69M	0	0
Dec 31, 2023	GOLDMAN SACHS GROUP INC	3.36%	2.24M	18.87M	1.68M	+300.28%
Dec 31, 2023	VANGUARD GROUP INC	4.11%	2.74M	23.08M	141.65K	+5.46%
Dec 31, 2023	OMEGA FUND MANAGEMENT, LLC	4.5%	3M	25.3M	0	0
Dec 31, 2023	VONTOBEL HOLDING LTD.	0.46%	305.41K	2.57M	305.41K	+100.00%
Dec 31, 2023	REDMILE GROUP, LLC	5.8%	3.87M	32.58M	-298.66K	-7.17%
Dec 31, 2023	MORGAN STANLEY	6.67%	4.45M	37.49M	3.98M	+847.51%
Dec 31, 2023	BLACKROCK INC.	6.81%	4.54M	38.26M	580.54K	+14.67%
Dec 31, 2023	STATE STREET CORP	7.67%	5.11M	43.09M	2.74M	+115.62%
Dec 31, 2023	PRICE T ROWE ASSOCIATES INC /MD/	8.78%	5.85M	49.31M	56.05K	+0.97%
Dec 31, 2023	GROUP ONE TRADING, L.P.	0.2%	135.24K	1.14B	89.4K	+195.03%
Dec 31, 2023	DEUTSCHE BANK AG\	0.21%	137.78K	1.16M	119.07K	+636.47%
Dec 31, 2023	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.23%	154.75K	1.3M	24.09K	+18.43%
Dec 31, 2023	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.25%	164.22K	1.38M	39.25K	+31.41%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.25%	168.57K	1.42M	1.14K	+0.68%
Dec 31, 2023	AMUNDI	0.26%	174.45K	1.62M	-407.64K	-70.03%
Dec 31, 2023	BAKER BROS. ADVISORS LP	14.32%	9.55M	80.47M	4.97M	+108.49%
Dec 31, 2023	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.27%	180.44K	1.52M	97.97K	+118.78%
Dec 31, 2023	CITIGROUP INC	0.28%	183.26K	1.54M	103.73K	+130.44%
Dec 31, 2023	NAN FUNG GROUP HOLDINGS LTD	0.28%	184.74K	1.56M	0	0
Dec 31, 2023	BNP PARIBAS ARBITRAGE, SNC	0.29%	196.25K	1.65M	164.49K	+517.90%
Dec 31, 2023	TWO SIGMA ADVISERS, LP	0.3%	202.7K	1.71M	-18.7K	-8.45%
Dec 31, 2023	CITADEL ADVISORS LLC	0.31%	207.54K	1.75M	-989.5K	-82.66%
Dec 31, 2023	UBS GROUP AG	0.33%	220.43K	1.86M	160.48K	+267.73%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.33%	220.65K	1.86M	94.98K	+75.58%
Dec 31, 2023	D. E. SHAW & CO., INC.	0.36%	243.01K	2.05M	162.3K	+201.11%
Dec 31, 2023	JANE STREET GROUP, LLC	0.37%	243.51K	2.05M	243.51K	+100.00%
Dec 31, 2023	WELLINGTON MANAGEMENT GROUP LLP	0.37%	246.62K	2.08M	246.62K	+100.00%
Dec 31, 2023	TD ASSET MANAGEMENT INC	0.4%	267.65K	2.26M	0	0
Dec 31, 2023	ENSIGN PEAK ADVISORS, INC	0.41%	270.01K	2.28M	0	0

Insiders

Insiders	Designation	Shares Held
OMEGA FUND IV, L.P.		4.76M
STAMPACCHIA OTELLO		4.67M
COFFIN ROBERT	director	1.82M
ASTLEY-SPARKE PHILIP	director	1.41M
RHODES JASON P	director	946K
LOVE COLIN	Chief Operating Officer	777.35K
PATEL SUSHIL	Chief Executive Officer	333.58K
ESPOSITO PAMELA	Chief Business Officer	263.44K
XYNOS KONSTANTINOS	Chief Medical Officer	139.69K
LEWIS TANYA	Chief Dev. Op. Officer	135.29K
HILL EMILY LUISA	Chief Financial Officer	134.37K
FRANCHI JEAN M.	Chief Financial Officer	128.75K
SARCHI CHRISTOPHER	Chief Commercial Officer	123.09K
SCHWENDENMAN ANDREW	Chief Accounting Officer	68.28K
DHINGRA KAPIL	director	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Dec 09, 2025	DHINGRA KAPIL	SALE	10.40	3.17K	32.96K	0
Dec 02, 2025	PATEL SUSHIL	SALE	11.13	10K	111.3K	333.58K
Nov 17, 2025	XYNOS KONSTANTINOS	SALE	9.10	7.25K	65.96K	139.69K
Nov 17, 2025	SARCHI CHRISTOPHER	SALE	9.10	5.21K	47.39K	123.09K
Aug 15, 2025	HILL EMILY LUISA	SALE	5.37	9.15K	49.16K	134.37K
May 20, 2025	HILL EMILY LUISA	SALE	8.05	2.54K	20.41K	143.52K
May 20, 2025	PATEL SUSHIL	SALE	8.06	25.11K	202.35K	343.58K
May 20, 2025	SCHWENDENMAN ANDREW	SALE	8.05	3.29K	26.46K	68.28K
May 20, 2025	XYNOS KONSTANTINOS	SALE	8.06	7.95K	64.09K	146.93K
May 20, 2025	ASTLEY-SPARKE PHILIP	SALE	8.06	32.28K	260.17K	1.41M
May 20, 2025	SARCHI CHRISTOPHER	SALE	8.05	3.75K	30.18K	128.3K
Dec 16, 2024	PATEL SUSHIL	SALE	12.42	10K	124.2K	202.01K
Nov 18, 2024	XYNOS KONSTANTINOS	SALE	10.78	7.25K	78.11K	109.89K
Nov 18, 2024	SARCHI CHRISTOPHER	SALE	10.78	5.21K	56.13K	87.05K
Aug 16, 2024	HILL EMILY LUISA	SALE	10.18	8.94K	90.99K	101.06K
Jun 07, 2024	XYNOS KONSTANTINOS	SALE	7.50	15.88K	119.11K	117.13K
May 16, 2024	XYNOS KONSTANTINOS	SALE	6.47	6.37K	41.19K	133.01K
May 16, 2024	COFFIN ROBERT	SALE	6.47	11.46K	74.17K	1.82M
May 16, 2024	ASTLEY-SPARKE PHILIP	SALE	6.47	37.93K	245.39K	1.49M
May 16, 2024	LOVE COLIN	SALE	6.47	17.62K	113.97K	777.35K
May 16, 2024	SCHWENDENMAN ANDREW	SALE	6.47	2.3K	14.87K	38.24K
May 16, 2024	SARCHI CHRISTOPHER	SALE	6.47	2.22K	14.35K	92.25K
May 16, 2024	PATEL SUSHIL	SALE	6.47	20.19K	130.66K	212.01K
Nov 16, 2023	SARCHI CHRISTOPHER	SALE	10.92	5.26K	57.38K	72.25K
Nov 16, 2023	XYNOS KONSTANTINOS	SALE	10.92	7.31K	79.86K	112.71K
Sep 12, 2023	ESPOSITO PAMELA	SALE	20.00	300	6K	263.44K
Sep 11, 2023	ESPOSITO PAMELA	SALE	20.01	5.36K	107.21K	263.44K
Aug 22, 2023	ESPOSITO PAMELA	SALE	20.01	18.6K	372.19K	263.44K
Aug 11, 2023	ESPOSITO PAMELA	SALE	20.00	1.4K	28K	263.44K
Jul 10, 2023	ESPOSITO PAMELA	SALE	21.12	2.08K	43.87K	263.44K
Jun 13, 2023	LEWIS TANYA	SALE	23.45	817	19.16K	135.29K
Jun 13, 2023	PATEL SUSHIL	SALE	23.44	553	12.96K	148.87K
May 16, 2023	FRANCHI JEAN M.	SALE	18.05	11.35K	204.89K	128.75K
May 16, 2023	XYNOS KONSTANTINOS	SALE	18.05	771	13.92K	120.03K
May 16, 2023	ASTLEY-SPARKE PHILIP	SALE	18.05	17.9K	323.13K	1.53M
May 16, 2023	PATEL SUSHIL	SALE	18.05	15.58K	281.13K	154.57K
May 16, 2023	COFFIN ROBERT	SALE	18.05	7.86K	141.89K	1.83M
May 16, 2023	LOVE COLIN	SALE	18.05	10.78K	194.49K	794.96K
May 16, 2023	ESPOSITO PAMELA	SALE	18.05	5.97K	107.69K	263.44K
May 16, 2023	LEWIS TANYA	SALE	18.05	12.21K	220.34K	148.15K
Dec 09, 2022	ESPOSITO PAMELA	SALE	25.03	15K	375.45K	229.4K
May 16, 2022	LOVE COLIN	SALE	14.59	6.32K	92.27K	765.74K
May 16, 2022	ESPOSITO PAMELA	SALE	14.59	3.51K	51.17K	229.4K
May 16, 2022	FRANCHI JEAN M.	SALE	14.59	3.44K	50.13K	95.1K
May 16, 2022	PATEL SUSHIL	SALE	14.59	10.69K	155.92K	130.15K
May 16, 2022	COFFIN ROBERT	SALE	14.59	5.74K	83.7K	1.8M
May 16, 2022	ASTLEY-SPARKE PHILIP	SALE	14.59	9.63K	140.53K	1.4M
May 16, 2022	LEWIS TANYA	SALE	14.59	5.47K	79.85K	120.36K
Mar 14, 2022	STAMPACCHIA OTELLO	SALE	15.55	38.76K	602.75K	4.67M
Nov 22, 2021	OMEGA FUND IV, L.P.	SALE	34.70	10.16K	352.62K	4.76M
Nov 19, 2021	OMEGA FUND IV, L.P.	SALE	34.80	417	14.51K	4.77M
Nov 18, 2021	OMEGA FUND IV, L.P.	SALE	33.50	2.44K	81.77K	4.81M
Nov 16, 2021	OMEGA FUND IV, L.P.	SALE	33.50	153	5.13K	4.81M
Nov 15, 2021	OMEGA FUND IV, L.P.	SALE	33.66	782	26.32K	4.81M
Nov 12, 2021	OMEGA FUND IV, L.P.	SALE	33.66	23.24K	782.09K	4.81M
Nov 11, 2021	OMEGA FUND IV, L.P.	SALE	33.61	18.28K	614.36K	4.84M
Nov 10, 2021	OMEGA FUND IV, L.P.	SALE	33.50	11	368.5	4.85M
Nov 09, 2021	OMEGA FUND IV, L.P.	SALE	33.73	7.54K	254.22K	4.85M
Nov 08, 2021	OMEGA FUND IV, L.P.	SALE	33.53	3.82K	127.98K	4.86M
Nov 05, 2021	OMEGA FUND IV, L.P.	SALE	33.50	5.79K	193.97K	4.87M
Nov 04, 2021	OMEGA FUND IV, L.P.	SALE	33.58	25.23K	847.06K	4.87M
Oct 18, 2021	LOVE COLIN	SALE	29.58	12.71K	375.99K	745.81K
Oct 15, 2021	LOVE COLIN	SALE	30.31	15.09K	457.35K	758.52K
Sep 23, 2021	OMEGA FUND IV, L.P.	SALE	33.58	12.17K	408.7K	4.9M
Sep 17, 2021	OMEGA FUND IV, L.P.	SALE	33.71	15.47K	521.33K	4.91M
Sep 16, 2021	OMEGA FUND IV, L.P.	SALE	32.55	5.54K	180.23K	5M
Sep 15, 2021	LOVE COLIN	SALE	31.23	30K	936.9K	775.81K
Aug 16, 2021	LOVE COLIN	SALE	29.27	2.7K	79.03K	805.81K
Aug 05, 2021	ESPOSITO PAMELA	SALE	35.09	25.8K	905.32K	210.16K
Aug 04, 2021	ESPOSITO PAMELA	SALE	35.00	4.2K	147K	210.16K
Jul 21, 2021	ESPOSITO PAMELA	SALE	33.17	12.54K	415.89K	210.16K
Jul 20, 2021	ESPOSITO PAMELA	SALE	33.05	4.86K	160.69K	210.16K
Jul 15, 2021	LOVE COLIN	SALE	32.02	30K	960.6K	835.81K
Jul 15, 2021	ESPOSITO PAMELA	SALE	33.37	4.6K	153.5K	210.16K
Jul 02, 2021	COFFIN ROBERT	SALE	40.04	7.81K	312.71K	1.78M
Jun 29, 2021	COFFIN ROBERT	SALE	40.05	22.83K	914.18K	1.78M
Jun 28, 2021	COFFIN ROBERT	SALE	40.04	14.66K	587.11K	1.81M
Jun 15, 2021	LOVE COLIN	SALE	34.53	12.2K	421.27K	865.81K
Apr 15, 2021	LOVE COLIN	SALE	29.98	2.7K	80.95K	895.81K
Mar 15, 2021	LOVE COLIN	SALE	32.67	100	3.27K	886.52K
Feb 16, 2021	LOVE COLIN	SALE	35.84	11.38K	407.86K	916.52K
Feb 08, 2021	OMEGA FUND IV, L.P.	SALE	45.00	5.25K	236.21K	5.14M
Jan 26, 2021	RHODES JASON P	SALE	46.14	5.56K	256.45K	946K
Jan 26, 2021	OMEGA FUND IV, L.P.	SALE	46.04	3.39K	156.21K	5.28M
Jan 22, 2021	OMEGA FUND IV, L.P.	SALE	45.03	3.27K	147.2K	5.31M
Jan 22, 2021	COFFIN ROBERT	SALE	43.99	29.8K	1.31M	1.74M
Jan 19, 2021	LOVE COLIN	SALE	43.25	700	30.28K	953.68K
Jan 19, 2021	ESPOSITO PAMELA	SALE	42.38	5.13K	217.28K	175.99K
Jan 19, 2021	ASTLEY-SPARKE PHILIP	SALE	42.40	7.63K	323.6K	1.26M
Jan 15, 2021	LOVE COLIN	SALE	43.07	12.4K	533.9K	954.38K
Jan 15, 2021	ASTLEY-SPARKE PHILIP	SALE	43.02	9.41K	404.78K	1.26M
Jan 15, 2021	ESPOSITO PAMELA	SALE	43.58	29.27K	1.28M	175.99K
Jan 14, 2021	ESPOSITO PAMELA	SALE	45.02	20K	900.4K	175.99K
Jan 14, 2021	ASTLEY-SPARKE PHILIP	SALE	43.06	100	4.31K	1.28M

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES25.63K4

NET SHARES-25.63K4

SHARES HELD596.35K4

% NET SHARES-104.3%0%

REPL Stock Ownership Breakdown

Replimune Group

Stock Outstanding Shares

Market Insider

Institutional Ownership

Insiders

Buying/Selling by Insiders

Insider Transaction Summary (6 Months)

Frequently Asked Questions

Stock Outstanding Shares

Market Insider

Institutional Ownership

Insiders

Buying/Selling by Insiders

Insider Transaction Summary (6 Months)

Frequently Asked Questions