How many institutions own PTGX stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own PTGX shares is 426, representing 113.64% of the company's common stock.

Who are the major shareholders selling Protagonist Therapeutics, Inc. stock?

MARSHALL WACE, LLP, in the last quarter, reduced its stake in PTGX by -38.72% restricting it's holding to 628.08 thousand shares of worth nearly $66.20M. PERCEPTIVE ADVISORS LLC also lessened -8.85% of the PTGX shares from its portfolio, reducing its holding to 1.23 million shares of worth $129.73M. STATE STREET CORP also shunned PTGX shares holding by -2.59% last quarter which brought its holding to 3.12 million shares worth $328.51M.

Investors who are buying PTGX stock?

As per its latest 13F filing, CLEARBRIDGE INVESTMENTS, LLC increased its stake in PTGX by 26.94% in the last quarter. The institutional holder raised its holding to 621.82 thousand shares having worth more than $65.54M. FMR LLC also added 22.62% more shares of PTGX to its portfolio, raising its holding to 662 thousand shares of worth $69.77M. BANK OF AMERICA CORP /DE/ also increased its PTGX shares holding by 49.32% which brought its holding to 1.3 million shares worth $136.54M.

PTGX's major insiders: who are they?

The insider with the most stakes in PTGX is Papanek Julie , director at the company. Additionally, PTGX stock is highly held by 10 percent owner JOHNSON & JOHNSON and 10 percent owner CANAAN X L.P. among others.

Did an insider recently sell PTGX stock?

Company executives, directors, and other insiders own 1.23% percent of Protagonist Therapeutics, Inc.'s stock. Within the last six months, there have been 20 transaction(s) in which PTGX insiders have sold stock, totaling 382.64K shares. Insiders that have sold shares include PATEL DINESH V PH D, GIRAUDO BRYAN, and ALI ASIF.

Which insider recently purchased PTGX stock?

There have been 0 transaction(s) during the past 6-months in which Protagonist Therapeutics, Inc. insiders have bought stock, totalling 0 shares

How much of PTGX does insiders own?

Around 4.13M Protagonist Therapeutics, Inc. shares are held by insiders, which represents about 1.23% of PTGX stock.

Who is the insider with the largest stake?

PTGX director, Papanek Julie holds the largest portfolio of the company's shares. PTGX shares owned by Papanek total nearly 2.45 million.

Which institution holds the most shares in PTGX?

CLEARBRIDGE INVESTMENTS, LLC is the largest institutional owner in PTGX which holds 621.82 thousand shares worth $65.54M or 0.98% of the total PTGX shares outstanding followed by MARSHALL WACE, LLP with ownership of 628.08 thousand shares representing 0.99% of the PTGX ownership. FMR LLC is the third largest stakeholder with 662 thousand shares or 1.04% of the ownership worth more than $69.77M.

Is Protagonist Therapeutics, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the PTGX is concerned, it is a stock which is optionable.

Is there a short position on PTGX's shares?

Number of PTGX shares short is 5.76M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding PTGX shares are there?

As of today, 62.21M shares of PTGX are outstanding.

Is there many float in PTGX stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, PTGX has 43.15M shares in float.

PTGX short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for PTGX is 7.93.

Protagonist Therapeutics (PTGX) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares9.25

Short Percent Of Float11.1

Shares Outstanding62.21M

Shares Float43.15M

Shares Short5.76M

Short Ratio7.93

11.1%

Short % of Float

9.25%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

1.23% Percentage of Shares held by All Insiders

113.64% Percentage of Shares held by All Institutions

115.05% Percentage of Float held by Institutions

426

Number of Institutions Holding Shares

Institutional Ownership

About 113.64% of PTGX shares are held by financial institutions. CLEARBRIDGE INVESTMENTS, LLC is the top corporate investor, holding 621.82K shares valued at $65.54M. A 0.98% stake in Protagonist Therapeutics, Inc. is owned by the company. MARSHALL WACE, LLP owns 628.08K shares valued at $66.20M, which translates its holding of 0.99% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Mar 31, 2026	CLEARBRIDGE INVESTMENTS, LLC	0.98%	621.82K	65.54M	131.98K	+26.94%
Mar 31, 2026	MARSHALL WACE, LLP	0.99%	628.08K	66.2M	-396.85K	-38.72%
Mar 31, 2026	FMR LLC	1.04%	662K	69.77M	122.12K	+22.62%
Mar 31, 2026	PERCEPTIVE ADVISORS LLC	1.94%	1.23M	129.73M	-119.55K	-8.85%
Mar 31, 2026	BANK OF AMERICA CORP /DE/	2.04%	1.3M	136.54M	427.85K	+49.32%
Mar 31, 2026	WOODLINE PARTNERS LP	2.22%	1.41M	149.05M	5.4K	+0.38%
Mar 31, 2026	CITADEL ADVISORS LLC	2.44%	1.55M	163.57M	425.21K	+37.74%
Mar 31, 2026	PRICE T ROWE ASSOCIATES INC /MD/	2.62%	1.67M	175.55M	264.76K	+18.90%
Mar 31, 2026	GEODE CAPITAL MANAGEMENT, LLC	2.63%	1.67M	175.98M	216.44K	+14.90%
Mar 31, 2026	INVESCO LTD.	3.41%	2.16M	228.16M	596.83K	+38.07%
Mar 31, 2026	JOHNSON & JOHNSON	3.85%	2.45M	258.14M	0	0
Mar 31, 2026	JANUS HENDERSON GROUP PLC	4.55%	2.89M	304.87M	241.55K	+9.12%
Mar 31, 2026	STATE STREET CORP	4.9%	3.12M	328.51M	-82.98K	-2.59%
Mar 31, 2026	WELLINGTON MANAGEMENT GROUP LLP	5.66%	3.6M	379.4M	428.22K	+13.50%
Mar 31, 2026	NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO	0.08%	49.02K	5.17M	126	+0.26%
Mar 31, 2026	NORDEA INVESTMENT MANAGEMENT AB	0.08%	51.82K	5.33M	51.82K	+100.00%
Mar 31, 2026	MOODY ALDRICH PARTNERS LLC	0.08%	53.89K	5.68M	-26.73K	-33.15%
Mar 31, 2026	BESSEMER GROUP INC	0.09%	54.18K	5.71M	16	+0.03%
Mar 31, 2026	ATIKA CAPITAL MANAGEMENT LLC	0.1%	62.1K	6.55M	-23.9K	-27.79%
Mar 31, 2026	KNOTT DAVID M JR	0.1%	63K	6.64M	-10K	-13.70%
Mar 31, 2026	GREAT LAKES ADVISORS, LLC	0.11%	71.04K	7.49M	-2.92K	-3.95%
Mar 31, 2026	ALGERT GLOBAL LLC	0.12%	78.47K	8.27M	73.38K	+1,441.65%
Mar 31, 2026	SEI INVESTMENTS CO	0.13%	83.2K	8.77M	45.85K	+122.77%
Mar 31, 2026	AXIOM INVESTORS LLC /DE	0.13%	85.48K	9.01M	-3.99K	-4.46%
Mar 31, 2026	FIRST TRUST ADVISORS LP	0.14%	87.86K	9.26M	41.4K	+89.13%
Mar 31, 2026	PRUDENTIAL FINANCIAL INC	0.15%	95.24K	10.04M	-15.13K	-13.71%
Mar 31, 2026	SWISS NATIONAL BANK	0.16%	98.9K	10.42M	700	+0.71%
Mar 31, 2026	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.17%	105.51K	11.12M	-8.52K	-7.47%
Mar 31, 2026	UBS ASSET MANAGEMENT AMERICAS INC	0.17%	107.44K	11.32M	2.91K	+2.78%
Mar 31, 2026	PANAGORA ASSET MANAGEMENT INC	0.18%	116.61K	12.29M	-8.78K	-7.00%
Mar 31, 2026	PUBLIC SECTOR PENSION INVESTMENT BOARD	0.33%	210.28K	22.16M	6.85K	+3.37%
Mar 31, 2026	VOYA INVESTMENT MANAGEMENT LLC	0.71%	454.38K	47.89M	88.22K	+24.09%
Mar 31, 2026	DIMENSIONAL FUND ADVISORS LP	0.8%	508.1K	53.54M	93.69K	+22.61%
Mar 31, 2026	AMERICAN CENTURY COMPANIES INC	0.85%	537.32K	56.63M	1.9K	+0.35%
Mar 31, 2026	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.87%	552.96K	58.28M	-3.81K	-0.68%
Mar 31, 2026	RTW INVESTMENTS, LP	7.96%	5.06M	533.22M	0	0
Mar 31, 2026	SEGALL BRYANT & HAMILL, LLC	0.33%	212.71K	22.42M	83.65K	+64.82%
Mar 31, 2026	UBS GROUP AG	8.14%	5.18M	545.74M	2.41M	+86.92%
Mar 31, 2026	FARALLON CAPITAL MANAGEMENT LLC	9.99%	6.35M	669.17M	204.9K	+3.34%
Mar 31, 2026	DEUTSCHE BANK AG\	0.2%	125.45K	13.22M	19.99K	+18.96%
Mar 31, 2026	NUVEEN, LLC	0.2%	127.91K	13.48M	2.05K	+1.63%
Mar 31, 2026	LEGAL & GENERAL GROUP PLC	0.21%	135.37K	14.27M	-13.8K	-9.25%
Mar 31, 2026	KENNEDY CAPITAL MANAGEMENT LLC	0.22%	137.1K	14.45M	-84.35K	-38.09%
Mar 31, 2026	FRANKLIN RESOURCES INC	0.22%	137.87K	14.53M	61.43K	+80.36%
Mar 31, 2026	NEUBERGER BERMAN GROUP LLC	0.22%	141.44K	14.91M	42.97K	+43.63%
Mar 31, 2026	RHUMBLINE ADVISERS	0.25%	157.41K	16.59M	2.46K	+1.59%
Mar 31, 2026	CITIGROUP INC	0.25%	158.71K	16.73M	63.8K	+67.22%
Mar 31, 2026	NAN FUNG TRINITY (HK) LTD	0.25%	160.67K	16.93M	-20K	-11.07%
Mar 31, 2026	LORD, ABBETT & CO. LLC	0.26%	163.46K	17.23M	163.46K	+100.00%
Mar 31, 2026	AFFINITY ASSET ADVISORS, LLC	0.27%	172.13K	18.14M	0	0
Mar 31, 2026	JPMORGAN CHASE & CO	0.27%	172.99K	17.28M	17.69K	+11.39%
Mar 31, 2026	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.44%	282.44K	29.77M	49.6K	+21.30%
Mar 31, 2026	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	0.48%	306.04K	32.26M	-24.77K	-7.49%
Mar 31, 2026	VESTAL POINT CAPITAL, LP	0.51%	326.16K	34.38M	326.16K	+100.00%
Mar 31, 2026	BANK OF NEW YORK MELLON CORP	0.54%	341.47K	35.99M	-8.92K	-2.55%
Mar 31, 2026	683 CAPITAL MANAGEMENT, LLC	0.56%	355K	37.42M	-25.67K	-6.74%
Mar 31, 2026	PRINCIPAL FINANCIAL GROUP INC	0.58%	367.82K	38.77M	19.89K	+5.72%
Mar 31, 2026	VANGUARD FIDUCIARY TRUST CO	0.65%	412.73K	43.5M	412.73K	+100.00%
Mar 31, 2026	RUBRIC CAPITAL MANAGEMENT LP	0.67%	428K	45.11M	428K	+100.00%
Mar 31, 2026	DRIEHAUS CAPITAL MANAGEMENT LLC	1.13%	720.93K	75.99M	-378.24K	-34.41%
Mar 31, 2026	GOLDMAN SACHS GROUP INC	1.23%	778.95K	82.1M	-182.2K	-18.96%
Mar 31, 2026	HOOD RIVER CAPITAL MANAGEMENT LLC	1.3%	829.29K	87.41M	829.29K	+100.00%
Mar 31, 2026	ADAR1 CAPITAL MANAGEMENT, LLC	1.56%	994.12K	104.78M	-55.05K	-5.25%
Mar 31, 2026	MORGAN STANLEY	1.6%	1.02M	107.32M	139.2K	+15.84%
Mar 31, 2026	FISHER ASSET MANAGEMENT, LLC	0.27%	173.97K	18.34M	108.86K	+167.18%
Mar 31, 2026	RAYMOND JAMES FINANCIAL INC	0.28%	177.36K	17.8M	-4.14K	-2.28%
Mar 31, 2026	NATIONALE-NEDERLANDEN POWSZECHNE TOWARZYSTWO EMERYTALNE S.A.	0.9%	571.83K	60.27M	0	0
Mar 31, 2026	PICTET ASSET MANAGEMENT HOLDING SA	0.91%	581.08K	61.25M	51.45K	+9.71%
Mar 31, 2026	BLACKROCK, INC.	15.38%	9.78M	1.03B	63.37K	+0.65%
Mar 31, 2026	JENNISON ASSOCIATES LLC	1.69%	1.07M	112.99M	740.85K	+223.71%
Mar 31, 2026	EAGLE HEALTH INVESTMENTS LP	0.28%	179.32K	18.9M	122.02K	+212.95%
Mar 31, 2026	TD ASSET MANAGEMENT INC	0.29%	183.7K	19.36M	24.97K	+15.73%
Mar 31, 2026	BNP PARIBAS ARBITRAGE, SNC	0.31%	194.53K	20.5M	96.77K	+98.98%
Mar 31, 2026	HOLOCENE ADVISORS, LP	0.33%	209.92K	22.13M	-103	-0.05%
Mar 31, 2026		0.36%	229.62K	24.2M	0	0
Mar 31, 2026	NORTHERN TRUST CORP	0.92%	587.97K	61.97M	12.85K	+2.23%
Mar 31, 2026	ALYESKA INVESTMENT GROUP, L.P.	0.93%	593.2K	62.52M	393.67K	+197.31%
Dec 31, 2025	PRINCIPAL FINANCIAL GROUP INC	0.55%	347.93K	30.39M	21.84K	+6.70%
Dec 31, 2025	HOLOCENE ADVISORS, LP	0.33%	210.02K	18.34M	210.02K	+100.00%
Dec 31, 2025		0.3%	189.82K	16.58M	189.82K	+100.00%
Dec 31, 2025	PANAGORA ASSET MANAGEMENT INC	0.2%	125.38K	10.95M	-23.35K	-15.70%
Dec 31, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.18%	114.04K	9.96M	23.72K	+26.26%
Dec 31, 2025	NUVEEN, LLC	0.2%	125.86K	10.99M	-2.52K	-1.97%
Dec 31, 2025	SEGALL BRYANT & HAMILL, LLC	0.2%	129.06K	11.27M	5.94K	+4.82%
Dec 31, 2025	AMERICAN CENTURY COMPANIES INC	0.84%	535.42K	46.76M	-64.62K	-10.77%
Dec 31, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.35%	221.44K	19.34M	13.01K	+6.24%
Dec 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.65%	414.42K	36.19M	-24.1K	-5.50%
Dec 31, 2025	CLEARBRIDGE INVESTMENTS, LLC	0.77%	489.84K	42.78M	489.84K	+100.00%
Dec 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.83%	529.63K	46.26M	-292.58K	-35.58%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.87%	556.76K	48.63M	3.89K	+0.70%
Dec 31, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.57%	366.17K	31.98M	60.75K	+19.89%
Dec 31, 2025	683 CAPITAL MANAGEMENT, LLC	0.6%	380.67K	33.25M	-26.83K	-6.58%
Dec 31, 2025	COMMODORE CAPITAL LP	0.71%	450K	39.3M	-575K	-56.10%
Dec 31, 2025	FMR LLC	0.85%	539.88K	47.15M	19.21K	+3.69%
Dec 31, 2025	NORTHERN TRUST CORP	0.9%	575.12K	50.23M	-28.1K	-4.66%
Dec 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	1.65%	1.05M	91.63M	59.99K	+6.06%
Dec 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	1.72%	1.1M	96M	-40.68K	-3.57%
Dec 31, 2025	PERCEPTIVE ADVISORS LLC	2.12%	1.35M	117.95M	320.29K	+31.09%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.15%	97.76K	8.54B	84.63K	+644.19%
Dec 31, 2025	FRANKLIN RESOURCES INC	0.12%	76.44K	6.68M	-6.48K	-7.81%
Dec 31, 2025	GREAT LAKES ADVISORS, LLC	0.12%	73.97K	6.46M	-15.21K	-17.05%
Dec 31, 2025	KNOTT DAVID M JR	0.11%	73K	6.38M	-10K	-12.05%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.11%	71.65K	6.26M	23.85K	+49.90%
Dec 31, 2025	JANE STREET GROUP, LLC	0.11%	69.6K	6.08M	43.8K	+169.77%
Dec 31, 2025	FISHER ASSET MANAGEMENT, LLC	0.1%	65.11K	5.69M	65.11K	+100.00%
Dec 31, 2025	EAGLE HEALTH INVESTMENTS LP	0.09%	57.3K	5M	57.3K	+100.00%
Dec 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.2%	1.4M	122.34M	180.3K	+14.77%
Dec 31, 2025	WOODLINE PARTNERS LP	2.21%	1.41M	123.04M	-29.48K	-2.05%
Dec 31, 2025	INVESCO LTD.	2.46%	1.57M	136.94M	564.13K	+56.21%
Dec 31, 2025	JANUS HENDERSON GROUP PLC	4.16%	2.65M	231.35M	1.55M	+140.73%
Dec 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	4.97%	3.17M	276.99M	1.26M	+66.18%
Dec 31, 2025	RTW INVESTMENTS, LP	7.93%	5.06M	441.86M	-697.22K	-12.11%
Dec 31, 2025	FARALLON CAPITAL MANAGEMENT LLC	9.63%	6.14M	536.62M	-52K	-0.84%
Dec 31, 2025	CAPTION MANAGEMENT, LLC	0.27%	174.8K	15.27M	156.8K	+871.11%
Dec 31, 2025	NAN FUNG TRINITY (HK) LTD	0.28%	180.67K	15.78M	35.78K	+24.69%
Dec 31, 2025	RAYMOND JAMES FINANCIAL INC	0.28%	181.5K	15.84M	-112.79K	-38.33%
Dec 31, 2025	BARCLAYS PLC	0.29%	187.64K	16.39M	16.24K	+9.47%
Dec 31, 2025	PUBLIC SECTOR PENSION INVESTMENT BOARD	0.32%	203.43K	17.77M	-24.72K	-10.84%
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.55%	348.6K	30.45M	280.1K	+408.91%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.55%	350.39K	30.6M	-12.87K	-3.54%
Dec 31, 2025	BESSEMER GROUP INC	0.08%	54.16K	4.73M	49.89K	+1,166.95%
Dec 31, 2025	BIRCHVIEW CAPITAL, LP	0.09%	55K	4.8M	7K	+14.58%
Dec 31, 2025	NEUBERGER BERMAN GROUP LLC	0.15%	98.47K	8.6M	-24.9K	-20.19%
Dec 31, 2025	NATIONALE-NEDERLANDEN POWSZECHNE TOWARZYSTWO EMERYTALNE S.A.	0.9%	571.83K	49.94M	571.83K	+100.00%
Dec 31, 2025	MORGAN STANLEY	1.38%	879.02K	76.77M	110.67K	+14.40%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	1.51%	961.15K	83.95M	179.44K	+22.95%
Dec 31, 2025	MARSHALL WACE, LLP	1.61%	1.02M	89.52M	-60.64K	-5.59%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.28%	1.45M	126.92M	36.28K	+2.56%
Dec 31, 2025	JOHNSON & JOHNSON	3.84%	2.45M	213.91M	0	0
Dec 31, 2025	UBS GROUP AG	4.34%	2.77M	241.93M	874.01K	+46.10%
Dec 31, 2025	STATE STREET CORP	5.02%	3.2M	279.46M	33.93K	+1.07%
Dec 31, 2025	VANGUARD GROUP INC	8.49%	5.41M	472.83M	1.16M	+27.16%
Dec 31, 2025	BLACKROCK, INC.	15.24%	9.72M	848.6M	311.77K	+3.32%
Dec 31, 2025	EAM INVESTORS, LLC	0.12%	78.5K	6.86M	-1.57K	-1.96%
Dec 31, 2025	MOODY ALDRICH PARTNERS LLC	0.13%	80.62K	7.04M	-62.44K	-43.64%
Dec 31, 2025	CITADEL ADVISORS LLC	1.77%	1.13M	98.4M	888.81K	+373.63%
Dec 31, 2025	AXIOM INVESTORS LLC /DE	0.14%	89.47K	7.81M	9.36K	+11.68%
Dec 31, 2025	CITIGROUP INC	0.15%	94.91K	8.29M	-57.67K	-37.80%
Dec 31, 2025	SWISS NATIONAL BANK	0.15%	98.2K	8.58M	2.1K	+2.19%
Dec 31, 2025	SOROS FUND MANAGEMENT LLC	0.16%	100K	8.73M	100K	+100.00%
Dec 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.16%	104.53K	9.13M	-5.7K	-5.17%
Dec 31, 2025	DEUTSCHE BANK AG\	0.17%	105.46K	9.21M	-11.75K	-10.03%
Dec 31, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.17%	109.62K	9.57M	109.62K	+100.00%
Dec 31, 2025	PRUDENTIAL FINANCIAL INC	0.17%	110.36K	9.64M	-16.04K	-12.69%
Dec 31, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.18%	113.34K	9.89M	-21.76K	-16.10%
Dec 31, 2025	LEGAL & GENERAL GROUP PLC	0.23%	149.16K	13.03M	-6.67K	-4.28%
Dec 31, 2025	RHUMBLINE ADVISERS	0.24%	154.95K	13.53B	-9.03K	-5.51%
Dec 31, 2025	JPMORGAN CHASE & CO	0.24%	155.3K	13.56M	-97.1K	-38.47%
Dec 31, 2025	TD ASSET MANAGEMENT INC	0.25%	158.73K	13.86M	8.3K	+5.52%
Dec 31, 2025	BOXER CAPITAL MANAGEMENT, LLC	0.27%	170K	14.85M	60K	+54.55%
Dec 31, 2025	AFFINITY ASSET ADVISORS, LLC	0.27%	172.13K	15.03M	-48.48K	-21.97%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	1.36%	867.58K	75.77M	37.7K	+4.54%
Dec 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.37%	232.84K	20.34M	-485.37K	-67.58%
Dec 31, 2025	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	0.52%	330.8K	28.89M	-120.96K	-26.78%
Dec 31, 2025	SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)	0.32%	205.57K	17.95M	126.78K	+160.89%
Dec 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.31%	199.52K	17.43M	199.52K	+100.00%
Dec 31, 2025	BIOIMPACT CAPITAL LLC	0.31%	199.47K	17.42M	199.47K	+100.00%
Dec 31, 2025	JENNISON ASSOCIATES LLC	0.52%	331.16K	28.92M	331.16K	+100.00%
Sep 30, 2025	PERCEPTIVE ADVISORS LLC	1.62%	1.03M	68.43M	-44.31K	-4.12%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.23%	781.71K	51.93M	4.4K	+0.57%
Sep 30, 2025	JEFFERIES FINANCIAL GROUP INC.	1.29%	821.5K	54.57M	-2.52K	-0.31%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.13%	718.2K	47.71M	-374.06K	-34.25%
Sep 30, 2025	COLONY GROUP, LLC	0.71%	448.99K	29.83M	448.99K	+100.00%
Sep 30, 2025	INVESCO LTD.	1.58%	1M	66.68M	282.03K	+39.08%
Sep 30, 2025	NORTHERN TRUST CORP	0.95%	603.22K	40.07M	-11.84K	-1.93%
Sep 30, 2025	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	0.71%	451.77K	30.01M	5.74K	+1.29%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.25%	155.83K	10.35M	-10.35K	-6.23%
Sep 30, 2025	AMERIPRISE FINANCIAL INC	0.24%	153.19K	10.18B	-15.18K	-9.02%
Sep 30, 2025	CITIGROUP INC	0.24%	152.58K	10.14M	74.63K	+95.74%
Sep 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	1.79%	1.14M	75.72M	382.14K	+50.43%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	1.31%	829.88K	55.13M	-21.96K	-2.58%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.87%	552.88K	36.73M	-22.49K	-3.91%
Sep 30, 2025	683 CAPITAL MANAGEMENT, LLC	0.64%	407.5K	27.07M	-37.5K	-8.43%
Sep 30, 2025	BARCLAYS PLC	0.27%	171.41K	11.39M	-40.71K	-19.19%
Sep 30, 2025	COMMODORE CAPITAL LP	1.61%	1.03M	68.09M	-50K	-4.65%
Sep 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.29%	822.21K	54.62M	70.24K	+9.34%
Sep 30, 2025	MORGAN STANLEY	1.21%	768.36K	51.04M	-100.6K	-11.58%
Sep 30, 2025	RHUMBLINE ADVISERS	0.26%	163.98K	10.89M	-9.05K	-5.23%
Sep 30, 2025	FMR LLC	0.82%	520.66K	34.59M	-17.77K	-3.30%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.69%	438.52K	29.13M	258.47K	+143.55%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	3%	1.91M	126.78M	870.71K	+83.90%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	1.92%	1.22M	81.08M	283.73K	+30.29%
Sep 30, 2025	JPMORGAN CHASE & CO	0.4%	252.4K	16.77M	-193.29K	-43.37%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.24%	150.43K	9.99M	34.1K	+29.31%
Sep 30, 2025	PANAGORA ASSET MANAGEMENT INC	0.23%	148.73K	9.88M	-61	-0.04%
Sep 30, 2025	NAN FUNG TRINITY (HK) LTD	0.23%	144.89K	9.63M	9.84K	+7.29%
Sep 30, 2025	MOODY ALDRICH PARTNERS LLC	0.23%	143.06K	9.5M	-27.51K	-16.13%
Sep 30, 2025	NUVEEN, LLC	0.2%	128.38K	8.53M	-1.13K	-0.87%
Sep 30, 2025	PRUDENTIAL FINANCIAL INC	0.2%	126.4K	8.4M	49K	+63.29%
Sep 30, 2025	NEUBERGER BERMAN GROUP LLC	0.19%	123.38K	8.2M	29.8K	+31.84%
Sep 30, 2025	SEGALL BRYANT & HAMILL, LLC	0.19%	123.13K	8.18M	2.97K	+2.47%
Sep 30, 2025	DEUTSCHE BANK AG\	0.18%	117.21K	7.79M	6.05K	+5.44%
Sep 30, 2025	SWISS NATIONAL BANK	0.15%	96.1K	6.38M	2.3K	+2.45%
Sep 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.14%	90.32K	6M	49.83K	+123.09%
Sep 30, 2025	GREAT LAKES ADVISORS, LLC	0.14%	89.17K	5.92M	-50.22K	-36.03%
Sep 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.13%	85.49K	5.68M	-5.44K	-5.98%
Sep 30, 2025	ATIKA CAPITAL MANAGEMENT LLC	0.13%	83K	5.51M	83K	+100.00%
Sep 30, 2025	KNOTT DAVID M JR	0.13%	83K	5.51M	3K	+3.75%
Sep 30, 2025	FRANKLIN RESOURCES INC	0.13%	82.92K	5.51M	339	+0.41%
Sep 30, 2025	EFG ASSET MANAGEMENT (NORTH AMERICA) CORP.	0.13%	82.64K	5.49M	913	+1.12%
Sep 30, 2025	SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)	0.12%	78.8K	5.23M	-3.95K	-4.78%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.12%	74.83K	4.97M	-5.72K	-7.10%
Sep 30, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.1%	65.76K	4.37M	-26.12K	-28.43%
Sep 30, 2025	FIRST TRUST ADVISORS LP	0.1%	62.72K	4.17M	-51.18K	-44.93%
Sep 30, 2025	NEW YORK STATE TEACHERS RETIREMENT SYSTEM	0.08%	49.55K	3.29M	-6.16K	-11.06%
Sep 30, 2025	BIRCHVIEW CAPITAL, LP	0.08%	48K	3.19M	0	0
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.08%	47.79K	3.17M	6.11K	+14.65%
Sep 30, 2025	SEI INVESTMENTS CO	0.07%	44.01K	2.92M	-921	-2.05%
Sep 30, 2025	DUQUESNE FAMILY OFFICE LLC	0.25%	159.7K	10.61M	159.7K	+100.00%
Sep 30, 2025	LYNX1 CAPITAL MANAGEMENT LP	1.1%	700.01K	46.5M	-33K	-4.50%
Sep 30, 2025	BLACKROCK, INC.	14.81%	9.4M	624.72M	-226.11K	-2.35%
Sep 30, 2025	FARALLON CAPITAL MANAGEMENT LLC	9.76%	6.2M	411.6M	24K	+0.39%
Sep 30, 2025	RTW INVESTMENTS, LP	9.06%	5.76M	382.39M	0	0
Sep 30, 2025	VANGUARD GROUP INC	6.7%	4.26M	282.81M	-101.37K	-2.33%
Sep 30, 2025	STATE STREET CORP	4.98%	3.17M	210.3M	-41.75K	-1.30%
Sep 30, 2025	BVF INC/IL	4.03%	2.56M	170.12M	-650.13K	-20.25%
Sep 30, 2025	JOHNSON & JOHNSON	3.86%	2.45M	162.7M	0	0
Sep 30, 2025	UBS GROUP AG	2.99%	1.9M	125.95M	-605.24K	-24.20%
Sep 30, 2025	DEEP TRACK CAPITAL, LP	2.7%	1.72M	113.97M	-1.53M	-47.14%
Sep 30, 2025	WOODLINE PARTNERS LP	2.26%	1.44M	95.54M	491.36K	+51.89%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.23%	1.42M	94.12M	-27.58K	-1.91%
Sep 30, 2025	JANUS HENDERSON GROUP PLC	1.73%	1.1M	73.17M	653.99K	+146.36%
Sep 30, 2025	MARSHALL WACE, LLP	1.71%	1.09M	72.11M	1.09M	+100.00%
Sep 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	1.56%	989.18K	65.71M	41.11K	+4.34%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.94%	600.05K	39.86M	-213.95K	-26.28%
Sep 30, 2025	MANGROVE PARTNERS	0.75%	478.41K	31.78M	83.03K	+21.00%
Sep 30, 2025	TORONTO DOMINION BANK	0.7%	445.44K	29.59M	0	0
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.57%	363.26K	24.13M	-24.82K	-6.40%
Sep 30, 2025	PRINCIPAL FINANCIAL GROUP INC	0.51%	326.09K	21.66M	-4.05K	-1.23%
Sep 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.48%	305.42K	20.29M	25.07K	+8.94%
Sep 30, 2025	LOGOS GLOBAL MANAGEMENT LP	0.47%	300K	19.93M	300K	+100.00%
Sep 30, 2025	RAYMOND JAMES FINANCIAL INC	0.46%	294.3K	19.55M	-17.69K	-5.67%
Sep 30, 2025	ALLIANCEBERNSTEIN L.P.	0.41%	260.85K	17.33M	192.95K	+284.17%
Sep 30, 2025	CITADEL ADVISORS LLC	0.37%	237.88K	15.8M	210.68K	+774.53%
Sep 30, 2025	PUBLIC SECTOR PENSION INVESTMENT BOARD	0.36%	228.15K	15.16M	16.87K	+7.98%
Sep 30, 2025	AFFINITY ASSET ADVISORS, LLC	0.35%	220.6K	14.65M	-219.4K	-49.86%
Sep 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.33%	208.44K	13.85M	73.55K	+54.52%
Jun 30, 2025	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	0.7%	446.03K	24.65M	66.38K	+17.48%
Jun 30, 2025	AMERIPRISE FINANCIAL INC	0.27%	168.37K	9.31M	31.53K	+23.04%
Jun 30, 2025	TORONTO DOMINION BANK	0.7%	445.44K	24.62M	0	0
Jun 30, 2025	BARCLAYS PLC	0.33%	212.11K	11.72M	100.68K	+90.35%
Jun 30, 2025	683 CAPITAL MANAGEMENT, LLC	0.7%	445K	24.6M	-55K	-11.00%
Jun 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.44%	280.35K	15.5M	220.68K	+369.78%
Jun 30, 2025	EVERSEPT PARTNERS, LP	0.44%	277.32K	15.33M	-269.8K	-49.31%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.61%	388.08K	21.45M	11.22K	+2.98%
Jun 30, 2025	MANGROVE PARTNERS	0.62%	395.38K	21.85M	0	0
Jun 30, 2025	JUPITER ASSET MANAGEMENT LTD	0.64%	405.64K	22.42M	237.58K	+141.36%
Jun 30, 2025	AFFINITY ASSET ADVISORS, LLC	0.69%	440K	24.32M	40K	+10.00%
Jun 30, 2025	JPMORGAN CHASE & CO	0.7%	445.69K	24.63M	-23.21K	-4.95%
Jun 30, 2025	JANUS HENDERSON GROUP PLC	0.7%	446.83K	24.7M	425.37K	+1,982.73%
Jun 30, 2025	EAM GLOBAL INVESTORS LLC	0.11%	69.73K	3.85M	-24	-0.03%
Jun 30, 2025	EAM INVESTORS, LLC	0.11%	71.97K	3.98M	2.79K	+4.03%
Jun 30, 2025	ROYAL BANK OF CANADA	0.12%	74.73K	4.13M	64.77K	+650.04%
Jun 30, 2025		0.12%	76.19K	4.21M	76.19K	+100.00%
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.12%	77.07K	4.26M	-210.23K	-73.18%
Jun 30, 2025	KNOTT DAVID M JR	0.13%	80K	4.42M	4K	+5.26%
Jun 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.13%	80.54K	4.45M	36.29K	+81.99%
Jun 30, 2025	CHECKPOINT CAPITAL L.P.	0.13%	81.31K	4.49M	-93.87K	-53.59%
Jun 30, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.14%	91.88K	5.08M	47K	+104.75%
Jun 30, 2025	OPALEYE MANAGEMENT INC.	0.17%	105K	5.8M	0	0
Jun 30, 2025	CAPITOLIS LIQUID GLOBAL MARKETS LLC	0.18%	116.1K	6.42M	116.1K	+100.00%
Jun 30, 2025	TD ASSET MANAGEMENT INC	0.18%	116.33K	6.43M	-53.6K	-31.54%
Jun 30, 2025	SEGALL BRYANT & HAMILL, LLC	0.19%	120.16K	6.64M	120.16K	+100.00%
Jun 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.21%	134.89K	7.46M	-2.61K	-1.90%
Jun 30, 2025	NAN FUNG TRINITY (HK) LTD	0.21%	135.05K	7.46M	135.05K	+100.00%
Jun 30, 2025	GREAT LAKES ADVISORS, LLC	0.22%	139.39K	7.7M	-12.93K	-8.49%
Jun 30, 2025	CAPTION MANAGEMENT, LLC	0.21%	135K	7.46M	-153.6K	-53.22%
Jun 30, 2025	FMR LLC	0.85%	538.43K	29.76M	60.09K	+12.56%
Jun 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.18%	751.98K	41.56M	456.38K	+154.40%
Jun 30, 2025	EFG ASSET MANAGEMENT (NORTH AMERICA) CORP.	0.13%	81.73K	4.52M	10.59K	+14.89%
Jun 30, 2025	SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)	0.13%	82.75K	4.57M	-166.2K	-66.76%
Jun 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	1.19%	757.71K	41.88M	522.64K	+222.33%
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	1.28%	814K	44.99M	128.17K	+18.69%
Jun 30, 2025	JEFFERIES FINANCIAL GROUP INC.	1.3%	824.02K	45.54M	192.13K	+30.40%
Jun 30, 2025	MORGAN STANLEY	1.37%	868.96K	48.03B	371.86K	+74.80%
Jun 30, 2025	WOODLINE PARTNERS LP	1.49%	946.88K	52.33M	49.19K	+5.48%
Jun 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	1.49%	948.07K	52.4M	8.4K	+0.89%
Jun 30, 2025	PERCEPTIVE ADVISORS LLC	1.69%	1.07M	59.38M	-16.82K	-1.54%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.72%	1.09M	60.37M	748.76K	+217.98%
Jun 30, 2025	JOHNSON & JOHNSON	3.86%	2.45M	136.4M	0	0
Jun 30, 2025	BVF INC/IL	5.06%	3.21M	177.47M	636.03K	+24.70%
Jun 30, 2025	DEEP TRACK CAPITAL, LP	5.11%	3.25M	179.4M	245.9K	+8.20%
Jun 30, 2025	RTW INVESTMENTS, LP	9.06%	5.76M	318.15M	36.86K	+0.64%
Jun 30, 2025	FARALLON CAPITAL MANAGEMENT LLC	9.72%	6.17M	341.13M	65K	+1.06%
Jun 30, 2025	BLACKROCK, INC.	15.16%	9.63M	532.27M	-106.43K	-1.09%
Jun 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.38%	243.37K	13.45M	34.62K	+16.58%
Jun 30, 2025	MOODY ALDRICH PARTNERS LLC	0.27%	170.57K	9.43M	7.09K	+4.34%
Jun 30, 2025	LEGAL & GENERAL GROUP PLC	0.26%	166.18K	9.18M	18.07K	+12.20%
Jun 30, 2025	PUBLIC SECTOR PENSION INVESTMENT BOARD	0.33%	211.28K	11.68M	22.25K	+11.77%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.28%	180.05K	9.95M	58.5K	+48.12%
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.27%	173.13K	9.57M	-150.43K	-46.49%
Jun 30, 2025	RHUMBLINE ADVISERS	0.27%	173.03K	9.56M	10.96K	+6.76%
Jun 30, 2025	UBS GROUP AG	3.94%	2.5M	138.24M	2.15M	+608.83%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.27%	1.44M	79.83M	20.67K	+1.45%
Jun 30, 2025	COMMODORE CAPITAL LP	1.69%	1.08M	59.42M	1.08M	+100.00%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	1.63%	1.04M	57.36M	50.37K	+5.10%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	1.47%	936.7K	51.77M	-385.3K	-29.15%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	1.34%	851.83K	47.08M	380.09K	+80.57%
Jun 30, 2025	INVESCO LTD.	1.14%	721.68K	39.89M	-137.97K	-16.05%
Jun 30, 2025	VANGUARD GROUP INC	6.86%	4.36M	240.9M	81.38K	+1.90%
Jun 30, 2025	STATE STREET CORP	5.05%	3.21M	177.28M	500.92K	+18.51%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	1.22%	777.31K	42.96B	221.76K	+39.92%
Jun 30, 2025	NORTHERN TRUST CORP	0.97%	615.07K	33.99M	-24.44K	-3.82%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.91%	575.36K	31.8M	17.65K	+3.16%
Jun 30, 2025	PRINCIPAL FINANCIAL GROUP INC	0.52%	330.13K	18.25M	-16.96K	-4.89%
Jun 30, 2025	RAYMOND JAMES FINANCIAL INC	0.49%	311.99K	17.24M	13.16K	+4.40%
Jun 30, 2025	LYNX1 CAPITAL MANAGEMENT LP	1.15%	733.01K	40.51M	0	0
Jun 30, 2025	HOLOCENE ADVISORS, LP	0.84%	530.33K	29.31M	530.33K	+100.00%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.88%	555.55K	26.87M	-203.14K	-26.78%
Mar 31, 2025	EVERSEPT PARTNERS, LP	0.87%	547.12K	26.46M	-131.67K	-19.40%
Mar 31, 2025	683 CAPITAL MANAGEMENT, LLC	0.79%	500K	24.18M	90K	+21.95%
Mar 31, 2025	MORGAN STANLEY	0.79%	497.11K	24.04M	-43.21K	-8.00%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.75%	471.75K	22.81M	336.87K	+249.77%
Mar 31, 2025	MANGROVE PARTNERS	0.63%	395.38K	19.12M	0	0
Mar 31, 2025	UBS GROUP AG	0.56%	352.87K	17.06M	220.26K	+166.10%
Mar 31, 2025	PRINCIPAL FINANCIAL GROUP INC	0.55%	347.1K	16.79M	9.29K	+2.75%
Mar 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.55%	343.5K	16.61M	343.5K	+100.00%
Mar 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.55%	343.41K	16.61M	31.09K	+9.96%
Mar 31, 2025	ARTIA GLOBAL PARTNERS LP	0.53%	333.85K	16.15M	40K	+13.61%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.51%	323.57K	15.65M	102.4K	+46.30%
Mar 31, 2025	RAYMOND JAMES FINANCIAL INC	0.47%	298.83K	14.45M	-4.49K	-1.48%
Mar 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.47%	295.59K	14.29M	-918	-0.31%
Mar 31, 2025	SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)	0.4%	248.95K	12.04M	-61.7K	-19.86%
Mar 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.33%	208.76K	10.1M	-79.16K	-27.49%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.89%	557.72K	26.97M	-20.69K	-3.58%
Mar 31, 2025	JEFFERIES FINANCIAL GROUP INC.	1%	631.89K	30.56M	-857.6K	-57.58%
Mar 31, 2025	NORTHERN TRUST CORP	1.02%	639.51K	30.93M	10.93K	+1.74%
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	1.49%	939.67K	45.44M	-80.66K	-7.91%
Mar 31, 2025	JOHNSON & JOHNSON	3.89%	2.45M	118.44M	0	0
Mar 31, 2025	BURNEY CO/	0.32%	201.99K	9.77M	201.99K	+100.00%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.6%	376.86K	18.23M	-13.93K	-3.56%
Mar 31, 2025	RTW INVESTMENTS, LP	9.08%	5.72M	276.59M	220.87K	+4.02%
Mar 31, 2025	JANE STREET GROUP, LLC	0.31%	193.3K	9.35M	131.75K	+214.05%
Mar 31, 2025	BVF INC/IL	4.09%	2.58M	124.53M	675K	+35.53%
Mar 31, 2025	VANGUARD GROUP INC	6.79%	4.28M	206.85M	57.18K	+1.36%
Mar 31, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.46%	287.3K	13.89M	287.3K	+100.00%
Mar 31, 2025	CAPTION MANAGEMENT, LLC	0.31%	193.9K	9.38M	104.7K	+117.38%
Mar 31, 2025	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	0.6%	379.65K	18.36M	253.75K	+201.55%
Mar 31, 2025	DEEP TRACK CAPITAL, LP	4.76%	3M	145.08M	2M	+200.00%
Mar 31, 2025	STATE STREET CORP	4.3%	2.71M	130.89M	-624.44K	-18.75%
Mar 31, 2025	AFFINITY ASSET ADVISORS, LLC	0.64%	400K	19.34M	270K	+207.69%
Mar 31, 2025	FARALLON CAPITAL MANAGEMENT LLC	9.7%	6.11M	295.33M	177K	+2.98%
Mar 31, 2025	LYNX1 CAPITAL MANAGEMENT LP	1.16%	733.01K	35.45M	733.01K	+100.00%
Mar 31, 2025	WOODLINE PARTNERS LP	1.43%	897.7K	43.41M	315.37K	+54.16%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	1.57%	987.37K	47.75M	47.29K	+5.03%
Mar 31, 2025	FMR LLC	0.76%	478.34K	23.13M	35.83K	+8.10%
Mar 31, 2025	NEW VERNON CAPITAL HOLDINGS II LLC	0.55%	348.1K	7.2M	345.03K	+11,271.94%
Mar 31, 2025	AMERICAN CENTURY COMPANIES INC	1.09%	685.82K	33.17M	-242.46K	-26.12%
Mar 31, 2025	COLONY GROUP, LLC	0.69%	435.1K	21.04M	9.54K	+2.24%
Mar 31, 2025	TORONTO DOMINION BANK	0.71%	445.44K	21.54M	104.47K	+30.64%
Mar 31, 2025	JPMORGAN CHASE & CO	0.74%	468.9K	22.68M	-108.08K	-18.73%
Mar 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.37%	235.07K	11.37M	-104.63K	-30.80%
Mar 31, 2025	PERCEPTIVE ADVISORS LLC	1.73%	1.09M	52.77M	-180.39K	-14.19%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.1%	1.32M	63.93M	-70.65K	-5.07%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.26%	1.42M	68.86M	46.5K	+3.38%
Mar 31, 2025	INVESCO LTD.	1.37%	859.65K	41.57M	120.7K	+16.33%
Mar 31, 2025	BLACKROCK, INC.	15.46%	9.74M	470.87M	-147.85K	-1.50%
Mar 31, 2024	RUBRIC CAPITAL MANAGEMENT LP	0.35%	198.06K	5.73M	198.06K	+100.00%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.08%	47.58K	1.38B	2.29K	+5.06%
Mar 31, 2024	BIRCHVIEW CAPITAL, LP	0.08%	48K	1.39M	0	0
Mar 31, 2024	KNOTT DAVID M JR	0.09%	52.37K	1.52M	0	0
Mar 31, 2024	GSA CAPITAL PARTNERS LLP	0.1%	55.36K	1.6M	35.57K	+179.76%
Mar 31, 2024	FIRST TRUST ADVISORS LP	0.11%	60.66K	1.75M	60.66K	+100.00%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.11%	62.16K	1.8M	62.16K	+100.00%
Mar 31, 2024	CREDIT SUISSE AG/	0.11%	63.02K	1.82M	507	+0.81%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.09%	50.2K	1.45M	50.2K	+100.00%
Mar 31, 2024	RHUMBLINE ADVISERS	0.15%	84.99K	2.46M	1.7K	+2.04%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.15%	85.4K	2.47M	0	0
Mar 31, 2024	CIBC WORLD MARKET INC.	0.15%	87K	2.52M	87K	+100.00%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.16%	89.66K	2.59M	21.23K	+31.02%
Mar 31, 2024	SWISS NATIONAL BANK	0.16%	90.7K	2.62M	0	0
Mar 31, 2024	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.16%	93.19K	2.7M	-14.36K	-13.35%
Mar 31, 2024	GREAT LAKES ADVISORS, LLC	0.17%	97.16K	2.81M	6.01K	+6.59%
Mar 31, 2024	AFFINITY ASSET ADVISORS, LLC	0.18%	100K	2.89M	100K	+100.00%
Mar 31, 2024	MOODY ALDRICH PARTNERS LLC	0.18%	100.52K	2.91M	38.19K	+61.28%
Mar 31, 2024	TREXQUANT INVESTMENT LP	0.18%	102.38K	2.96M	102.38K	+100.00%
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.19%	108.45K	3.14B	-2.35K	-2.12%
Mar 31, 2024	PRIVIUM FUND MANAGEMENT B.V.	0.2%	114.02K	3.3M	114.02K	+100.00%
Mar 31, 2024	ADAR1 CAPITAL MANAGEMENT, LLC	1.38%	785.66K	22.73M	584.8K	+291.15%
Mar 31, 2024	PRICE T ROWE ASSOCIATES INC /MD/	1.44%	819.3K	23.7M	-4.44K	-0.54%
Mar 31, 2024	WALLEYE CAPITAL LLC	0.24%	134.11K	3.88M	-51.31K	-27.67%
Mar 31, 2024	ALGERT GLOBAL LLC	0.26%	147.84K	4.28M	72.08K	+95.15%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.28%	157.59K	4.56M	-1.25K	-0.79%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.28%	160.32K	4.64M	121.98K	+318.11%
Mar 31, 2024	UBS GROUP AG	0.31%	177.55K	5.14M	26.68K	+17.68%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.33%	187.23K	5.42M	-15.94K	-7.85%
Mar 31, 2024	SILVERCREST ASSET MANAGEMENT GROUP LLC	0.33%	188.74K	5.46M	8.25K	+4.57%
Mar 31, 2024	FMR LLC	0.82%	466.09K	13.48M	133	+0.03%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.87%	496.56K	14.37M	41.24K	+9.06%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.93%	525.04K	15.19M	9.82K	+1.91%
Mar 31, 2024	NORTHERN TRUST CORP	0.95%	539K	15.59M	-11.14K	-2.03%
Mar 31, 2024	DRIEHAUS CAPITAL MANAGEMENT LLC	0.99%	560.53K	16.22M	361.84K	+182.11%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	1.19%	678.2K	19.62M	372.78K	+122.06%
Mar 31, 2024	683 CAPITAL MANAGEMENT, LLC	1.23%	700K	20.25M	-15K	-2.10%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	1.39%	791.34K	22.89M	-25.19K	-3.09%
Mar 31, 2024	MARSHALL WACE, LLP	1.72%	976.89K	28.26M	834.42K	+585.68%
Mar 31, 2024	POINT72 ASSET MANAGEMENT, L.P.	2.11%	1.2M	34.71M	-1.41M	-54.09%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	2.28%	1.29M	37.43M	45.46K	+3.64%
Mar 31, 2024	COWEN AND COMPANY, LLC	2.74%	1.56M	45.06M	1.56M	+100.00%
Mar 31, 2024	MORGAN STANLEY	3.31%	1.88M	54.38M	688.04K	+57.73%
Mar 31, 2024	ADAGE CAPITAL PARTNERS GP, L.L.C.	3.91%	2.22M	64.19M	927.17K	+71.78%
Mar 31, 2024	STATE STREET CORP	5.77%	3.27M	94.67M	542.56K	+19.87%
Mar 31, 2024	BVF INC/IL	6.62%	3.76M	108.66M	-1.99M	-34.62%
Mar 31, 2024	RTW INVESTMENTS, LP	9.36%	5.32M	153.78M	0	0
Mar 31, 2024	FARALLON CAPITAL MANAGEMENT LLC	10.11%	5.74M	166.03M	4.54K	+0.08%
Mar 31, 2024	PERCEPTIVE ADVISORS LLC	1.75%	994.32K	28.77M	611.06K	+159.44%
Mar 31, 2024	KYNAM CAPITAL MANAGEMENT, LP	2.02%	1.14M	33.1M	-860.63K	-42.93%
Mar 31, 2024	JEFFERIES FINANCIAL GROUP INC.	2.08%	1.18M	34.15M	-90K	-7.08%
Mar 31, 2024	JOHNSON & JOHNSON	4.31%	2.45M	70.85M	0	0
Mar 31, 2024	VANGUARD GROUP INC	5.63%	3.19M	92.37M	39.06K	+1.24%
Mar 31, 2024	BLACKROCK INC.	9.81%	5.57M	161.13M	25.58K	+0.46%
Mar 31, 2024	TWO SIGMA ADVISERS, LP	0.35%	196.7K	5.69M	-25.3K	-11.40%
Mar 31, 2024	CIBC WORLD MARKETS CORP	0.35%	200K	5.79M	200K	+100.00%
Mar 31, 2024	CITIGROUP INC	0.37%	208.64K	6.04M	135.94K	+186.98%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.4%	228.44K	6.61M	75.03K	+48.91%
Mar 31, 2024	JPMORGAN CHASE & CO	0.42%	237.44K	6.87M	-173.61K	-42.24%
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	0.42%	239.21K	6.92M	71.41K	+42.56%
Mar 31, 2024	CHECKPOINT CAPITAL L.P.	0.49%	280.3K	8.11M	13.45K	+5.04%
Mar 31, 2024	KENNEDY CAPITAL MANAGEMENT LLC	0.53%	298.07K	8.62M	-6.72K	-2.21%
Mar 31, 2024	UBS ASSET MANAGEMENT AMERICAS INC	0.59%	335.32K	9.7M	46.24K	+16.00%
Mar 31, 2024	CANDRIAM S.C.A.	0.63%	360K	10.41M	-177K	-32.96%
Mar 31, 2024	GRATUS CAPITAL LLC	0.72%	408.17K	11.81M	10.6K	+2.67%
Mar 31, 2024	EVERSEPT PARTNERS, LP	0.72%	411.48K	11.9M	-126.6K	-23.53%
Mar 31, 2024	MANGROVE PARTNERS	0.77%	439.31K	12.71M	0	0
Mar 31, 2024	WOODLINE PARTNERS LP	1.12%	636.96K	18.43M	636.96K	+100.00%
Mar 31, 2024	DEUTSCHE BANK AG\	1.6%	910.81K	26.35M	794	+0.09%
Mar 31, 2024	FAIRMOUNT FUNDS MANAGEMENT LLC	1.64%	931.89K	26.96M	931.89K	+100.00%
Mar 31, 2024	HENNION & WALSH ASSET MANAGEMENT, INC.	0.06%	34.9K	1.01M	849	+2.49%
Mar 31, 2024	PROFUND ADVISORS LLC	0.07%	37.48K	1.08B	9.59K	+34.37%
Mar 31, 2024	RESOLUTE CAPITAL ASSET PARTNERS LLC	0.07%	39.5K	1.14M	39.5K	+100.00%
Mar 31, 2024	ALPS ADVISORS INC	0.07%	41.1K	1.19M	1.03K	+2.56%
Mar 31, 2024	STATE OF WISCONSIN INVESTMENT BOARD	0.07%	41.49K	1.2M	1.69K	+4.24%
Mar 31, 2024	SEI INVESTMENTS CO	0.07%	41.76K	1.21B	4.53K	+12.17%
Mar 31, 2024	BNP PARIBAS ARBITRAGE, SNC	0.08%	47.23K	1.37M	-24.67K	-34.31%
Dec 31, 2023	DEUTSCHE BANK AG\	1.54%	910.01K	20.87M	838.1K	+1,165.43%
Dec 31, 2023	PRICE T ROWE ASSOCIATES INC /MD/	1.39%	823.74K	18.89M	-8.25K	-0.99%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	1.38%	816.54K	18.72M	-124.74K	-13.25%
Dec 31, 2023	683 CAPITAL MANAGEMENT, LLC	1.21%	715K	16.39M	-17.78K	-2.43%
Dec 31, 2023	NORTHERN TRUST CORP	0.93%	550.14K	12.61M	-12.55K	-2.23%
Dec 31, 2023	EVERSEPT PARTNERS, LP	0.91%	538.07K	12.34M	251.33K	+87.65%
Dec 31, 2023	CANDRIAM S.C.A.	0.91%	537K	12.31M	-93K	-14.76%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.87%	515.22K	11.81M	48.02K	+10.28%
Dec 31, 2023	FMR LLC	0.79%	465.95K	10.68M	-43.29K	-8.50%
Dec 31, 2023	SIO CAPITAL MANAGEMENT, LLC	0.78%	460.04K	10.55M	211.92K	+85.41%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.77%	455.32K	10.44M	16.22K	+3.69%
Dec 31, 2023	MANGROVE PARTNERS	0.74%	439.31K	10.07M	0	0
Dec 31, 2023	JPMORGAN CHASE & CO	0.69%	411.05K	9.43M	178.76K	+76.95%
Dec 31, 2023	GRATUS CAPITAL LLC	0.67%	397.57K	9.12M	104.7K	+35.75%
Dec 31, 2023	PERCEPTIVE ADVISORS LLC	0.65%	383.26K	8.79M	-671.01K	-63.65%
Dec 31, 2023	CITADEL ADVISORS LLC	0.58%	342.6K	7.86M	11.1K	+3.35%
Dec 31, 2023	IKARIAN CAPITAL, LLC	0.54%	319K	7.31M	319K	+100.00%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.52%	305.42K	7M	-230.61K	-43.02%
Dec 31, 2023	KENNEDY CAPITAL MANAGEMENT LLC	0.52%	304.79K	6.99M	-14.74K	-4.61%
Dec 31, 2023	JOHNSON & JOHNSON	4.14%	2.45M	56.16M	0	0
Dec 31, 2023	KYNAM CAPITAL MANAGEMENT, LP	3.39%	2M	45.97M	186.22K	+10.24%
Dec 31, 2023	ADAGE CAPITAL PARTNERS GP, L.L.C.	2.18%	1.29M	29.62M	591.7K	+84.53%
Dec 31, 2023	UBS ASSET MANAGEMENT AMERICAS INC	0.49%	289.08K	6.63M	218.02K	+306.82%
Dec 31, 2023	DEEP TRACK CAPITAL, LP	0.47%	275.2K	6.31M	275.2K	+100.00%
Dec 31, 2023	TWO SIGMA ADVISERS, LP	0.38%	222K	5.09M	-94.9K	-29.95%
Dec 31, 2023	RENAISSANCE TECHNOLOGIES LLC	0.36%	213.97K	4.91M	-12.3K	-5.44%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.34%	203.18K	4.66M	1.73K	+0.86%
Dec 31, 2023		0.34%	200.86K	4.61M	200.86K	+100.00%
Dec 31, 2023	DRIEHAUS CAPITAL MANAGEMENT LLC	0.34%	198.69K	4.56M	198.69K	+100.00%
Dec 31, 2023	WALLEYE CAPITAL LLC	0.31%	185.43K	4.25M	51.61K	+38.57%
Dec 31, 2023	SILVERCREST ASSET MANAGEMENT GROUP LLC	0.3%	180.5K	4.14M	34	+0.02%
Dec 31, 2023	RAFFERTY ASSET MANAGEMENT, LLC	0.28%	167.8K	3.85M	-182.49K	-52.10%
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	0.27%	158.84K	3.64M	-177.47K	-52.77%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.26%	153.41K	3.52M	-85.63K	-35.82%
Dec 31, 2023	UBS GROUP AG	0.25%	150.87K	3.46M	60.14K	+66.29%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	0.25%	149.16K	3.42M	149.16K	+100.00%
Dec 31, 2023	BARCLAYS PLC	0.25%	148.97K	3.42M	-27.86K	-15.76%
Dec 31, 2023	BVF INC/IL	9.71%	5.74M	131.73M	0	0
Dec 31, 2023	FARALLON CAPITAL MANAGEMENT LLC	9.69%	5.73M	131.49M	288K	+5.29%
Dec 31, 2023	BLACKROCK INC.	9.37%	5.54M	127.12M	314.48K	+6.01%
Dec 31, 2023	RTW INVESTMENTS, LP	8.98%	5.32M	121.88M	-100K	-1.85%
Dec 31, 2023	VANGUARD GROUP INC	5.33%	3.15M	72.32M	-74.48K	-2.31%
Dec 31, 2023	STATE STREET CORP	4.61%	2.73M	62.6M	-1.21M	-30.75%
Dec 31, 2023	POINT72 ASSET MANAGEMENT, L.P.	4.42%	2.61M	59.93M	1.51M	+135.84%
Dec 31, 2023	JEFFERIES FINANCIAL GROUP INC.	2.15%	1.27M	29.13M	435K	+52.06%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	2.11%	1.25M	28.63M	67.03K	+5.67%
Dec 31, 2023	MORGAN STANLEY	2.01%	1.19M	27.33M	762.83K	+177.81%

Insiders

Among the PTGX insiders holding of 1.23% of the stake in company, PAPANEK JULIE, director, holds the largest shares of 2.45M. JOHNSON & JOHNSON, 10 percent owner, is the second largest PTGX insider with ownership of 2.45M shares. CANAAN X L.P., 10 percent owner, stands third with possession of 2.12M shares of that stake.

Insiders	Designation	Shares Held
PAPANEK JULIE	director	2.45M
JOHNSON & JOHNSON	10 percent owner	2.45M
CANAAN X L.P.	10 percent owner	2.12M
SHANAFELT ARMEN		2.1M
LV MANAGEMENT GROUP, LLC	10 percent owner	2.1M
PATEL DINESH V PH D	President and CEO	523.48K
GUPTA SUNEEL	Chief Development Officer	266.98K
MOLINA ARTURO MD	Chief Medical Officer	84.12K
SELICK HAROLD E	director	60.85K
ALI ASIF	Chief Financial Officer	59K
LIU DAVID Y	Chief Scientific Officer	58.25K
SHAMES RICHARD S.	Chief Medical Officer	32.02K
WILLIAMS LEWIS T	director	7.83K
WADDILL WILLIAM D.	director	7.83K
KALKOFEN DONALD A.	Chief Financial Officer	613
GIRAUDO BRYAN	director	0
KHOSLA CHAITAN PHD	director	0
O'NEIL THOMAS P.	Chief Financial Officer	0
NOONBERG SARAH B.	director	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
May 12, 2026	PATEL DINESH V PH D	SALE	100.12	75K	7.51M	523.48K
May 08, 2026	GIRAUDO BRYAN	SALE	100.00	6K	600K	0
May 07, 2026	GIRAUDO BRYAN	SALE	100.07	12K	1.2M	6K
Apr 20, 2026	ALI ASIF	SALE	105.47	1.75K	184.57K	59K
Mar 26, 2026	MOLINA ARTURO MD	SALE	104.79	15K	1.57M	84.12K
Mar 26, 2026	ALI ASIF	SALE	104.24	24.77K	2.58M	60.75K
Mar 26, 2026	SELICK HAROLD E	SALE	105.00	24K	2.52M	60.85K
Mar 25, 2026	PATEL DINESH V PH D	SALE	101.00	54.64K	5.52M	524.94K
Feb 17, 2026	WILLIAMS LEWIS T	SALE	82.42	18K	1.48M	7.83K
Feb 06, 2026	WADDILL WILLIAM D.	SALE	83.68	20K	1.67M	7.83K
Jan 27, 2026	ALI ASIF	SALE	83.14	18.2K	1.51M	60.32K
Jan 27, 2026	PATEL DINESH V PH D	SALE	83.19	4.07K	338.42K	574.51K
Jan 27, 2026	MOLINA ARTURO MD	SALE	82.00	5K	410K	84.12K
Jan 26, 2026	MOLINA ARTURO MD	SALE	82.28	5K	411.4K	84.12K
Jan 26, 2026	PATEL DINESH V PH D	SALE	84.05	14.21K	1.19M	574.51K
Jan 23, 2026	MOLINA ARTURO MD	SALE	82.42	13.15K	1.08M	84.12K
Jan 23, 2026	PATEL DINESH V PH D	SALE	84.59	19.32K	1.63M	574.51K
Jan 20, 2026	MOLINA ARTURO MD	SALE	82.48	9.51K	784.71K	97.27K
Jan 20, 2026	ALI ASIF	SALE	82.48	8.59K	708.34K	78.08K
Jan 20, 2026	PATEL DINESH V PH D	SALE	82.48	34.44K	2.84M	580.51K
Nov 17, 2025	MOLINA ARTURO MD	SALE	84.77	2.71K	229.9K	81.18K
Oct 10, 2025	WADDILL WILLIAM D.	SALE	87.81	8K	702.48K	5.13K
Sep 22, 2025	WADDILL WILLIAM D.	SALE	64.25	4K	257K	5.13K
Aug 27, 2025	WADDILL WILLIAM D.	SALE	59.25	4K	237K	9.13K
Jul 25, 2025	PATEL DINESH V PH D	SALE	54.78	10.42K	570.53K	520.6K
Jul 23, 2025	PATEL DINESH V PH D	SALE	54.79	17.52K	959.92K	531.02K
Jul 22, 2025	PATEL DINESH V PH D	SALE	55.05	22.07K	1.21M	548.54K
Jul 21, 2025	PATEL DINESH V PH D	SALE	54.86	12.86K	705.44K	570.6K
Jun 10, 2025	MOLINA ARTURO MD	SALE	57.03	10K	570.3K	83.89K
Jun 09, 2025	MOLINA ARTURO MD	SALE	55.51	10K	555.1K	83.89K
Apr 22, 2025	ALI ASIF	SALE	46.00	1.76K	80.78K	61.07K
Mar 17, 2025	WADDILL WILLIAM D.	SALE	54.25	4K	217K	13.13K
Mar 13, 2025	MOLINA ARTURO MD	SALE	55.74	30.51K	1.7M	83.89K
Mar 12, 2025	ALI ASIF	SALE	58.73	24.9K	1.46M	62.82K
Feb 19, 2025	PATEL DINESH V PH D	SALE	38.18	5.36K	204.61K	540.26K
Jan 16, 2025	MOLINA ARTURO MD	SALE	0.00	3.25K	-	83.89K
Jan 16, 2025	ALI ASIF	SALE	0.00	2.6K	-	62.82K
Nov 27, 2024	MOLINA ARTURO MD	SALE	44.83	16K	717.28K	46.44K
Nov 26, 2024	PATEL DINESH V PH D	SALE	46.25	21.48K	993.45K	408.46K
Nov 26, 2024	MOLINA ARTURO MD	SALE	45.60	5.53K	252.12K	46.44K
Nov 26, 2024	GUPTA SUNEEL	SALE	45.50	19.19K	873.19K	266.98K
Nov 25, 2024	PATEL DINESH V PH D	SALE	46.96	78.52K	3.69M	435.21K
Nov 25, 2024	GUPTA SUNEEL	SALE	46.04	103.44K	4.76M	256.17K
Nov 15, 2024	MOLINA ARTURO MD	SALE	40.98	1.91K	78.11K	46.44K
Sep 11, 2024	ALI ASIF	SALE	44.47	12K	533.64K	34.96K
Sep 10, 2024	WADDILL WILLIAM D.	SALE	45.00	8K	360K	12K
Jul 24, 2024	WADDILL WILLIAM D.	SALE	40.00	8K	320K	12K
Jun 07, 2024	PATEL DINESH V PH D	SALE	35.19	35K	1.23M	515.42K
Jun 07, 2024	WADDILL WILLIAM D.	SALE	35.00	8K	280K	12K
Apr 18, 2024	ALI ASIF	SALE	25.11	1.23K	30.99K	37.16K
Apr 01, 2024	PATEL DINESH V PH D	SALE	28.31	25K	707.75K	549.59K
Mar 01, 2024	WADDILL WILLIAM D.	SALE	31.34	12.98K	406.64K	12K
Mar 01, 2024	ALI ASIF	SALE	32.33	2.25K	72.68K	38.4K
Mar 01, 2024	PATEL DINESH V PH D	SALE	31.62	30K	948.6K	574.59K
Feb 29, 2024	ALI ASIF	SALE	31.00	2.09K	64.76K	40.65K
Jan 09, 2024	GUPTA SUNEEL	SALE	25.00	5K	125K	187.57K
Dec 13, 2023	PATEL DINESH V PH D	SALE	20.08	75K	1.51M	534.35K
Nov 15, 2023	MOLINA ARTURO MD	SALE	16.24	1.85K	30.01K	22.53K
Dec 21, 2021	PATEL DINESH V PH D	SALE	32.14	15K	482.17K	477.16K
Aug 17, 2021	LIU DAVID Y	SALE	47.56	14.78K	702.89K	58.25K
Feb 11, 2021	NOONBERG SARAH B.	SALE	25.09	3.7K	92.83K	0
Feb 10, 2021	NOONBERG SARAH B.	SALE	26.04	400	10.42K	0
Jan 19, 2021	PATEL DINESH V PH D	SALE	24.60	24.85K	611.1K	426.14K
Aug 11, 2020	KHOSLA CHAITAN PHD	SALE	17.19	2.5K	42.95K	0
Mar 12, 2020	SELICK HAROLD E	PURCHASE	6.70	12K	80.4K	15.31K
Dec 03, 2019	GUPTA SUNEEL	PURCHASE	5.13	30K	153.9K	49.5K
Dec 03, 2019	KALKOFEN DONALD A.	PURCHASE	5.10	613	3.13K	613
Dec 03, 2019	PATEL DINESH V PH D	PURCHASE	5.55	10K	55.5K	389.82K
Dec 03, 2019	GIRAUDO BRYAN	PURCHASE	5.70	8K	45.62K	8K
Aug 06, 2019	PATEL DINESH V PH D	SALE	8.85	10.79K	95.54K	374.79K
Aug 06, 2019	LIU DAVID Y	SALE	8.85	3.4K	30.04K	49.8K
Mar 01, 2019	SHAMES RICHARD S.	SALE	8.03	657	5.28K	32.02K
Mar 01, 2019	LIU DAVID Y	SALE	8.03	810	6.5K	51.2K
Mar 01, 2019	PATEL DINESH V PH D	SALE	8.03	2.18K	17.53K	383.83K
Feb 06, 2019	SHAMES RICHARD S.	SALE	7.71	2.58K	19.89K	24.18K
Feb 06, 2019	LIU DAVID Y	SALE	7.74	3.82K	29.56K	37.01K
Feb 06, 2019	PATEL DINESH V PH D	SALE	7.71	10.13K	78.12K	357.26K
May 17, 2018	CANAAN X L.P.	SALE	6.09	38.97K	237.36K	2.12M
May 16, 2018	CANAAN X L.P.	SALE	6.46	29.44K	190.07K	2.16M
May 15, 2018	CANAAN X L.P.	SALE	6.48	57.72K	374.08K	2.18M
May 14, 2018	CANAAN X L.P.	SALE	6.37	77.59K	494.22K	2.24M
Mar 23, 2018	CANAAN X L.P.	SALE	20.71	59.95K	1.24M	2.32M
Mar 22, 2018	CANAAN X L.P.	SALE	20.62	4.76K	98.13K	2.38M
Mar 21, 2018	CANAAN X L.P.	SALE	20.61	17.7K	364.73K	2.38M
Mar 20, 2018	CANAAN X L.P.	SALE	20.61	17.06K	351.54K	2.4M
Mar 19, 2018	CANAAN X L.P.	SALE	20.57	13.44K	276.45K	2.42M
Mar 16, 2018	CANAAN X L.P.	SALE	20.51	6.93K	142.06K	2.43M
Mar 15, 2018	CANAAN X L.P.	SALE	20.64	11.75K	242.52K	2.44M
Mar 14, 2018	CANAAN X L.P.	SALE	20.77	200	4.15K	2.45M
Mar 13, 2018	CANAAN X L.P.	SALE	20.84	1.2K	25.09K	2.45M
Mar 12, 2018	LIU DAVID Y	SALE	21.29	3.5K	74.5K	15.03K
Mar 02, 2018	LIU DAVID Y	SALE	20.00	875	17.5K	13.32K
Jan 16, 2018	LIU DAVID Y	SALE	20.00	875	17.5K	3.82K
Dec 22, 2017	SHAMES RICHARD S.	SALE	20.50	3.53K	72.34K	0
Dec 21, 2017	PATEL DINESH V PH D	SALE	19.56	8.21K	160.57K	190.44K
Dec 20, 2017	PATEL DINESH V PH D	SALE	19.55	1.79K	34.99K	190.44K
Dec 18, 2017	LIU DAVID Y	SALE	20.00	875	17.5K	3.82K
Dec 18, 2017	O'NEIL THOMAS P.	SALE	20.00	8K	160K	0
Nov 30, 2017	LIU DAVID Y	SALE	20.00	875	17.5K	3.82K
Nov 13, 2017	LIU DAVID Y	SALE	16.97	3.5K	59.38K	3.82K
Oct 05, 2017	SHAMES RICHARD S.	SALE	19.00	2.02K	38.32K	0
Sep 12, 2017	SHAMES RICHARD S.	SALE	14.31	3.69K	52.75K	0
Aug 29, 2017	SHAMES RICHARD S.	SALE	17.00	1.51K	25.7K	1.87K
Aug 28, 2017	LIU DAVID Y	SALE	15.00	3.5K	52.5K	2K
Jul 10, 2017	LIU DAVID Y	SALE	12.68	3.5K	44.38K	2K
May 16, 2017	GIRAUDO BRYAN	PURCHASE	6.46	10K	64.57K	10K
Aug 16, 2016	CANAAN X L.P.	PURCHASE	12.00	583.33K	7M	2.45M
Aug 16, 2016	SHANAFELT ARMEN	PURCHASE	12.00	583.33K	7M	2.1M
Aug 16, 2016	LV MANAGEMENT GROUP, LLC	PURCHASE	12.00	583.33K	7M	2.1M
Aug 16, 2016	PAPANEK JULIE	PURCHASE	12.00	583.33K	7M	2.45M
Aug 16, 2016	JOHNSON & JOHNSON	PURCHASE	12.00	583.33K	7M	2.45M

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES382.64K20

NET SHARES-382.64K20

SHARES HELD4.13M20

% NET SHARES-109.27%0%

Frequently Asked Questions