How many institutions own ORIC stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own ORIC shares is 190, representing 99.21% of the company's common stock.

Who are the major shareholders selling ORIC Pharmaceuticals, Inc. stock?

VANGUARD GROUP INC, in the last quarter, reduced its stake in ORIC by -2.33% restricting it's holding to 4.54 million shares of worth nearly $37.15M. FIRST TURN MANAGEMENT, LLC also lessened -6.91% of the ORIC shares from its portfolio, reducing its holding to 2.01 million shares of worth $16.44M. VIVO CAPITAL, LLC also shunned ORIC shares holding by -32.25% last quarter which brought its holding to 2.12 million shares worth $17.33M.

Investors who are buying ORIC stock?

As per its latest 13F filing, FRANKLIN RESOURCES INC increased its stake in ORIC by 2.64% in the last quarter. The institutional holder raised its holding to 1.21 million shares having worth more than $9.92M. DIMENSIONAL FUND ADVISORS LP also added 54.59% more shares of ORIC to its portfolio, raising its holding to 1.23 million shares of worth $10.04M. ROYCE & ASSOCIATES LP also increased its ORIC shares holding by 3.35% which brought its holding to 1.51 million shares worth $12.33M.

ORIC's major insiders: who are they?

The insider with the most stakes in ORIC is ORBIMED ADVISORS LLC , director at the company. Additionally, ORIC stock is highly held by director GORDON CARL L and 10 percent owner Topspin Fund L.P. among others.

Did an insider recently sell ORIC stock?

Company executives, directors, and other insiders own 6.94% percent of ORIC Pharmaceuticals, Inc.'s stock. Within the last six months, there have been 9 transaction(s) in which ORIC insiders have sold stock, totaling 319.31K shares. Insiders that have sold shares include HEYMAN RICHARD A., PISCITELLI DOMINIC, and CHACKO JACOB.

Which insider recently purchased ORIC stock?

There have been 0 transaction(s) during the past 6-months in which ORIC Pharmaceuticals, Inc. insiders have bought stock, totalling 0 shares

How much of ORIC does insiders own?

Around 3.19M ORIC Pharmaceuticals, Inc. shares are held by insiders, which represents about 6.94% of ORIC stock.

Who is the insider with the largest stake?

ORIC director, ORBIMED ADVISORS LLC holds the largest portfolio of the company's shares. ORIC shares owned by ORBIMED total nearly 2.21 million.

Which institution holds the most shares in ORIC?

VANGUARD GROUP INC is the largest institutional owner in ORIC which holds 4.54 million shares worth $37.15M or 4.59% of the total ORIC shares outstanding followed by FRANKLIN RESOURCES INC with ownership of 1.21 million shares representing 1.23% of the ORIC ownership. DIMENSIONAL FUND ADVISORS LP is the third largest stakeholder with 1.23 million shares or 1.24% of the ownership worth more than $10.04M.

Is ORIC Pharmaceuticals, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the ORIC is concerned, it is a stock which is optionable.

Is there a short position on ORIC's shares?

Number of ORIC shares short is 6.76M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding ORIC shares are there?

As of today, 97.12M shares of ORIC are outstanding.

Is there many float in ORIC stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, ORIC has 53.43M shares in float.

ORIC short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for ORIC is 5.99.

ORIC Pharmaceuticals (ORIC) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares7.93

Short Percent Of Float8.05

Shares Outstanding97.12M

Shares Float53.43M

Shares Short6.76M

Short Ratio5.99

8.05%

Short % of Float

7.93%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

6.94% Percentage of Shares held by All Insiders

99.21% Percentage of Shares held by All Institutions

106.6% Percentage of Float held by Institutions

190

Number of Institutions Holding Shares

Institutional Ownership

About 99.21% of ORIC shares are held by financial institutions. VANGUARD GROUP INC is the top corporate investor, holding 4.54M shares valued at $37.15M. A 4.59% stake in ORIC Pharmaceuticals, Inc. is owned by the company. FRANKLIN RESOURCES INC owns 1.21M shares valued at $9.92M, which translates its holding of 1.23% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	VANGUARD GROUP INC	4.59%	4.54M	37.15M	-108.16K	-2.33%
Dec 31, 2025	FRANKLIN RESOURCES INC	1.23%	1.21M	9.92M	31.22K	+2.64%
Dec 31, 2025	DIMENSIONAL FUND ADVISORS LP	1.24%	1.23M	10.04M	433.36K	+54.59%
Dec 31, 2025	ROYCE & ASSOCIATES LP	1.52%	1.51M	12.33M	48.82K	+3.35%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.77%	1.75M	14.32M	119.95K	+7.36%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	1.96%	1.94M	15.86M	1.03M	+114.33%
Dec 31, 2025	FIRST TURN MANAGEMENT, LLC	2.03%	2.01M	16.44M	-149.17K	-6.91%
Dec 31, 2025	VIVO CAPITAL, LLC	2.14%	2.12M	17.33M	-1.01M	-32.25%
Dec 31, 2025	COLUMN GROUP LLC	3.58%	3.54M	28.96M	0	0
Dec 31, 2025	ECOR1 CAPITAL, LLC	6.8%	6.73M	55.04M	0	0
Dec 31, 2025	REDMILE GROUP, LLC	0.45%	448.11K	3.67M	448.11K	+100.00%
Dec 31, 2025	POLAR CAPITAL HOLDINGS PLC	0.51%	502.36K	4.11M	33.75K	+7.20%
Dec 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.55%	549K	4.49M	101.63K	+22.72%
Dec 31, 2025	NORTHERN TRUST CORP	0.89%	885.48K	7.24M	-3.06K	-0.34%
Dec 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.96%	950.21K	7.77M	-569.1K	-37.46%
Dec 31, 2025	EUCLIDEAN CAPITAL LLC	1%	989.41K	8.09M	0	0
Dec 31, 2025	SPHERA FUNDS MANAGEMENT LTD.	1.02%	1M	8.22M	572.69K	+132.66%
Dec 31, 2025	ARROWMARK COLORADO HOLDINGS LLC	1.08%	1.06M	8.7M	-33.73K	-3.07%
Dec 31, 2025	INTEGRAL HEALTH ASSET MANAGEMENT, LLC	1.21%	1.2M	9.82M	300K	+33.33%
Dec 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	1.22%	1.21M	9.86M	1.21M	+100.00%
Dec 31, 2025	PARADIGM BIOCAPITAL ADVISORS LP	2.43%	2.4M	19.64M	2.4M	+100.00%
Dec 31, 2025	FMR LLC	2.51%	2.48M	20.28M	-49.13K	-1.94%
Dec 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	2.95%	2.92M	23.91M	303.16K	+11.57%
Dec 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	3.33%	3.3M	26.96M	423.8K	+14.76%
Dec 31, 2025	ORBIMED ADVISORS LLC	3.68%	3.64M	29.79M	0	0
Dec 31, 2025	NEA MANAGEMENT COMPANY, LLC	4.16%	4.12M	33.69M	0	0
Dec 31, 2025	ALKEON CAPITAL MANAGEMENT LLC	4.55%	4.5M	36.84M	0	0
Dec 31, 2025	OPTIMIZE FINANCIAL INC	0.04%	39.61K	324.03K	568	+1.45%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.04%	40.12K	328.14K	-198.51K	-83.19%
Dec 31, 2025	STATE STREET CORP	4.3%	4.26M	34.83M	1.85M	+77.14%
Dec 31, 2025	SR ONE CAPITAL MANAGEMENT, LP	4.56%	4.51M	37.75M	0	0
Dec 31, 2025	PFIZER INC	5.43%	5.38M	43.98M	0	0
Dec 31, 2025	BLACKROCK, INC.	5.94%	5.88M	48.06M	598.43K	+11.34%
Dec 31, 2025	JPMORGAN CHASE & CO	0.42%	414.79K	3.39M	-813.74K	-66.24%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.63%	621.09K	5.08M	17.88K	+2.96%
Dec 31, 2025	BARCLAYS PLC	0.73%	718.54K	5.88M	534.44K	+290.32%
Dec 31, 2025	UBS GROUP AG	0.74%	734.86K	6.01M	395.62K	+116.62%
Dec 31, 2025	EVENTIDE ASSET MANAGEMENT, LLC	0.96%	952.37K	7.79M	864	+0.09%
Dec 31, 2025	SIREN, L.L.C.	1.02%	1.01M	8.24M	0	0
Dec 31, 2025	VR ADVISER, LLC	5.74%	5.68M	46.43M	-920.66K	-13.96%
Dec 31, 2025	VIKING GLOBAL INVESTORS LP	6.64%	6.57M	53.76M	-9	0.00%
Dec 31, 2025	NEXTECH INVEST, LTD.	7.24%	7.16M	58.59M	0	0
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.08%	82.53K	675.11K	31.57K	+61.94%
Dec 31, 2025	SWISS NATIONAL BANK	0.09%	86.2K	705.12K	20.1K	+30.41%
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	0.1%	97.43K	796.99K	-43K	-30.62%
Dec 31, 2025	XTX TOPCO LTD	0.11%	110.57K	904.42K	110.57K	+100.00%
Dec 31, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.13%	128.65K	1.04M	1.99K	+1.57%
Dec 31, 2025	AMERICAN CENTURY COMPANIES INC	0.14%	134.93K	1.1M	4.35K	+3.33%
Dec 31, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.14%	141.05K	1.15M	36.37K	+34.75%
Dec 31, 2025	NUVEEN, LLC	0.15%	144.4K	1.18M	6.71K	+4.87%
Dec 31, 2025	CITIGROUP INC	0.16%	154.15K	1.26M	143.52K	+1,349.59%
Dec 31, 2025	TD ASSET MANAGEMENT INC	0.17%	169.83K	1.39M	18.13K	+11.95%
Dec 31, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.17%	170.07K	1.39M	23.02K	+15.66%
Dec 31, 2025	AQR CAPITAL MANAGEMENT LLC	0.18%	174.28K	1.43M	2.35K	+1.37%
Dec 31, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.18%	177.18K	1.45M	91.59K	+107.00%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.19%	187.92K	1.54M	12.21K	+6.95%
Dec 31, 2025	SQUAREPOINT OPS LLC	0.23%	229.38K	1.88M	198.65K	+646.37%
Dec 31, 2025	JANE STREET GROUP, LLC	0.25%	244.03K	2B	181.36K	+289.34%
Dec 31, 2025		0.62%	615.72K	5.04B	615.72K	+100.00%
Dec 31, 2025	VICTORY CAPITAL MANAGEMENT INC	0.34%	332.76K	2.72M	200.54K	+151.67%
Dec 31, 2025	Y-INTERCEPT (HONG KONG) LTD	0.35%	341.42K	2.79M	341.42K	+100.00%
Dec 31, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.35%	350.88K	2.87M	334.45K	+2,034.72%
Dec 31, 2025	LOGOS GLOBAL MANAGEMENT LP	0.45%	450K	3.68M	450K	+100.00%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	0.51%	507.51K	4.15M	404.06K	+390.58%
Dec 31, 2025	BLUE OWL CAPITAL HOLDINGS LP	0.52%	515K	4.21M	515K	+100.00%
Dec 31, 2025	LORD, ABBETT & CO. LLC	0.57%	564.25K	4.62M	564.25K	+100.00%
Dec 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.58%	572.72K	4.68M	558.22K	+3,849.82%
Dec 31, 2025	BIOIMPACT CAPITAL LLC	1.82%	1.8M	14.71M	69.34K	+4.01%
Dec 31, 2025	CITADEL ADVISORS LLC	2.46%	2.43M	19.92M	1.24M	+103.23%
Dec 31, 2025	SG AMERICAS SECURITIES, LLC	0.04%	41.02K	336K	22.99K	+127.58%
Dec 31, 2025	QUEST PARTNERS LLC	0.04%	44.39K	363.09K	28.89K	+186.37%
Dec 31, 2025	DEUTSCHE BANK AG\	0.05%	44.94K	367.59K	2.44K	+5.74%
Dec 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.05%	50.78K	415.4K	27.55K	+118.56%
Dec 31, 2025	PROFUND ADVISORS LLC	0.07%	65.16K	533.01K	46.44K	+248.08%
Dec 31, 2025	GSA CAPITAL PARTNERS LLP	0.07%	70.63K	578K	38.71K	+121.23%
Dec 31, 2025	RHUMBLINE ADVISERS	0.08%	77.71K	635.63K	-4.33K	-5.27%
Dec 31, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	1.13%	1.12M	9.13M	-832.2K	-42.70%
Dec 31, 2025	MORGAN STANLEY	1.21%	1.19M	9.77M	448.55K	+60.16%
Sep 30, 2025	NORTHERN TRUST CORP	1.14%	888.54K	10.66M	487.58K	+121.61%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.06%	45.08K	540.92K	27.29K	+153.36%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.07%	50.96K	611.56K	17.36K	+51.66%
Sep 30, 2025	SWISS NATIONAL BANK	0.08%	66.1K	793.2K	66.1K	+100.00%
Sep 30, 2025	RHUMBLINE ADVISERS	0.11%	82.03K	984.37K	10.6K	+14.84%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.11%	85.59K	1.03M	42.95K	+100.71%
Sep 30, 2025	INVESCO LTD.	0.12%	91.61K	1.1M	30.05K	+48.81%
Sep 30, 2025	CITADEL ADVISORS LLC	1.53%	1.2M	14.38M	-204.76K	-14.60%
Sep 30, 2025	JPMORGAN CHASE & CO	1.57%	1.23M	14.74M	-106.92K	-8.01%
Sep 30, 2025	ROYCE & ASSOCIATES LP	1.87%	1.46M	17.5M	1.22M	+521.23%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	1.94%	1.52M	18.23M	-258.43K	-14.54%
Sep 30, 2025	VIVO CAPITAL, LLC	4%	3.13M	37.52M	0	0
Sep 30, 2025	COLUMN GROUP LLC	4.53%	3.54M	42.49M	0	0
Sep 30, 2025	ALKEON CAPITAL MANAGEMENT LLC	5.77%	4.5M	54.05M	0	0
Sep 30, 2025	SR ONE CAPITAL MANAGEMENT, LP	5.78%	4.51M	54.18M	0	0
Sep 30, 2025	VANGUARD GROUP INC	5.95%	4.65M	55.8M	1.53M	+48.82%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.17%	130.58K	1.57M	39.37K	+43.16%
Sep 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.17%	132.22K	1.59M	-410	-0.31%
Sep 30, 2025	NUVEEN, LLC	0.18%	137.69K	1.65M	15.01K	+12.23%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.19%	151.7K	1.82M	-26K	-14.63%
Sep 30, 2025	STEMPOINT CAPITAL LP	0.21%	166.46K	2M	-34.32K	-17.09%
Sep 30, 2025	RESOLUTE CAPITAL ASSET PARTNERS LLC	0.21%	167.52K	2.01M	-60K	-26.37%
Sep 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.22%	171.93K	2.06M	492	+0.29%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.22%	175.71K	2.11M	40.68K	+30.13%
Sep 30, 2025	SPHERA FUNDS MANAGEMENT LTD.	0.55%	431.69K	5.18M	37K	+9.37%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.57%	447.37K	5.37M	81.97K	+22.43%
Sep 30, 2025	POLAR CAPITAL HOLDINGS PLC	0.6%	468.61K	5.62M	468.61K	+100.00%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.77%	603.21K	7.24M	220.82K	+57.75%
Sep 30, 2025	MORGAN STANLEY	0.95%	745.53K	8.95M	350.74K	+88.84%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.16%	904.81K	10.86M	415.18K	+84.79%
Sep 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	1.22%	951.51K	11.42M	74	+0.01%
Sep 30, 2025	EUCLIDEAN CAPITAL LLC	1.27%	989.41K	11.87M	0	0
Sep 30, 2025	SIREN, L.L.C.	1.29%	1.01M	12.09M	0	0
Sep 30, 2025	ARROWMARK COLORADO HOLDINGS LLC	1.4%	1.1M	13.17M	-180.96K	-14.15%
Sep 30, 2025	FRANKLIN RESOURCES INC	1.51%	1.18M	14.18M	138.77K	+13.31%
Sep 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	3.35%	2.62M	31.44M	-230.73K	-8.09%
Sep 30, 2025	NEA MANAGEMENT COMPANY, LLC	5.27%	4.12M	49.42M	0	0
Sep 30, 2025	ECOR1 CAPITAL, LLC	8.61%	6.73M	80.74M	5.11M	+315.81%
Sep 30, 2025	NICHOLAS INVESTMENT PARTNERS, LP	0.28%	220.74K	2.65M	146.49K	+197.32%
Sep 30, 2025	BLACKROCK, INC.	6.75%	5.28M	63.32M	1.2M	+29.39%
Sep 30, 2025	PFIZER INC	6.88%	5.38M	64.52M	0	0
Sep 30, 2025	VIKING GLOBAL INVESTORS LP	8.41%	6.57M	78.87M	0	0
Sep 30, 2025	ARIZONA STATE RETIREMENT SYSTEM	0.01%	10.06K	120.67K	10.06K	+100.00%
Sep 30, 2025	CITIGROUP INC	0.01%	10.63K	127.61K	-21.92K	-67.33%
Sep 30, 2025	CWM, LLC	0.02%	12.29K	148K	-164	-1.32%
Sep 30, 2025	PROSHARE ADVISORS LLC	0.02%	13.38K	160.6K	1.53K	+12.88%
Sep 30, 2025	INTEGRAL HEALTH ASSET MANAGEMENT, LLC	1.15%	900K	10.8M	-350K	-28.00%
Sep 30, 2025	CAMPBELL & CO INVESTMENT ADVISER LLC	0.02%	13.97K	167.64K	-5.7K	-28.97%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.02%	14.5K	174K	4.3K	+42.16%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.09%	1.63M	19.57M	522.28K	+47.12%
Sep 30, 2025	BIOIMPACT CAPITAL LLC	2.21%	1.73M	20.75M	0	0
Sep 30, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	2.49%	1.95M	23.39M	147.98K	+8.22%
Sep 30, 2025	FIRST TURN MANAGEMENT, LLC	2.76%	2.16M	25.91M	149.55K	+7.44%
Sep 30, 2025	STATE STREET CORP	3.08%	2.4M	28.85M	771.82K	+47.29%
Sep 30, 2025	FMR LLC	3.24%	2.53M	30.34M	57.99K	+2.35%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	3.68%	2.87M	34.46M	108.41K	+3.92%
Sep 30, 2025	ORBIMED ADVISORS LLC	4.66%	3.64M	43.7M	2.74M	+304.96%
Sep 30, 2025	VR ADVISER, LLC	8.44%	6.6M	79.16M	0	0
Sep 30, 2025	NEXTECH INVEST, LTD.	9.17%	7.16M	85.95M	0	0
Sep 30, 2025	CLEAR HARBOR ASSET MANAGEMENT, LLC	0.02%	15.12K	181.43K	0	0
Sep 30, 2025	QUEST PARTNERS LLC	0.02%	15.5K	186K	-4.66K	-23.10%
Sep 30, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.02%	15.64K	187.72K	4.96K	+46.42%
Sep 30, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.02%	16.44K	197.24M	16.44K	+100.00%
Sep 30, 2025	FOX RUN MANAGEMENT, L.L.C.	0.02%	16.89K	202.64K	16.89K	+100.00%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.02%	17.38K	208.6K	-8.06K	-31.69%
Sep 30, 2025	SG AMERICAS SECURITIES, LLC	0.02%	18.02K	216K	18.02K	+100.00%
Sep 30, 2025	PROFUND ADVISORS LLC	0.02%	18.72K	224.64K	18.72K	+100.00%
Sep 30, 2025	LEGATO CAPITAL MANAGEMENT LLC	0.03%	23.4K	280.75K	23.4K	+100.00%
Sep 30, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.03%	27.02K	324.29K	12.75K	+89.27%
Sep 30, 2025	GSA CAPITAL PARTNERS LLP	0.04%	31.93K	383K	31.93K	+100.00%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.04%	33.13K	397.51K	28.79K	+663.45%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	1.02%	793.87K	9.52M	79.01K	+11.05%
Sep 30, 2025	BARCLAYS PLC	0.24%	184.09K	2.21M	41.41K	+29.02%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.31%	238.62K	2.86M	151.87K	+175.05%
Sep 30, 2025	WOODLINE PARTNERS LP	0.32%	246.53K	2.96M	2.17K	+0.89%
Sep 30, 2025	SECTORAL ASSET MANAGEMENT INC	0.42%	328.66K	3.94M	97.17K	+41.98%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.19%	150.59K	1.81M	-72.71K	-32.56%
Sep 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.19%	148.78K	1.79M	148.78K	+100.00%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	33.97K	407.64K	6.9K	+25.48%
Sep 30, 2025	OPTIMIZE FINANCIAL INC	0.05%	39.04K	468.53K	39.04K	+100.00%
Sep 30, 2025	DEUTSCHE BANK AG\	0.05%	42.5K	509.96K	3.92K	+10.16%
Sep 30, 2025	PALUMBO WEALTH MANAGEMENT LLC	0.06%	44.03K	528.31K	-2.76K	-5.89%
Sep 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.19%	147.05K	1.76M	-2.68K	-1.79%
Sep 30, 2025	UBS GROUP AG	0.43%	339.24K	4.07M	240.23K	+242.64%
Jun 30, 2025	EUCLIDEAN CAPITAL LLC	1.27%	989.41K	10.04M	0	0
Jun 30, 2025	NEA MANAGEMENT COMPANY, LLC	5.27%	4.12M	41.8M	1.92M	+87.59%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.49%	382.39K	3.88M	-26.12K	-6.39%
Jun 30, 2025	SUPERSTRING CAPITAL MANAGEMENT LP	0.44%	344.92K	3.5M	-474.27K	-57.90%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.38%	298.44K	3.03M	38.64K	+14.87%
Jun 30, 2025	SECTORAL ASSET MANAGEMENT INC	0.3%	231.49K	2.35M	211.49K	+1,057.43%
Jun 30, 2025	RESOLUTE CAPITAL ASSET PARTNERS LLC	0.29%	227.52K	2.31M	227.52K	+100.00%
Jun 30, 2025	NORTHERN TRUST CORP	0.51%	400.95K	4.07M	-145.79K	-26.67%
Jun 30, 2025	SPHERA FUNDS MANAGEMENT LTD.	0.51%	394.69K	4.01M	159.86K	+68.07%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.47%	365.4K	3.71M	365.4K	+100.00%
Jun 30, 2025	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.06%	43.39K	440.44K	-25.64K	-37.14%
Jun 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.05%	42.64K	432.84K	-34.78K	-44.92%
Jun 30, 2025	LMR PARTNERS LLP	0.05%	35.27K	357.96K	-33	-0.09%
Jun 30, 2025	BLACKROCK, INC.	5.22%	4.08M	41.39M	-1.36M	-24.97%
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	3.65%	2.85M	28.93M	2.85M	+100.00%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	3.54%	2.76M	28.04M	1.43M	+107.29%
Jun 30, 2025	FMR LLC	3.16%	2.47M	25.07M	-10.36K	-0.42%
Jun 30, 2025	FIRST TURN MANAGEMENT, LLC	2.57%	2.01M	20.4M	-17.51K	-0.86%
Jun 30, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	2.31%	1.8M	18.28M	-259.41K	-12.59%
Jun 30, 2025	STATE STREET CORP	2.09%	1.63M	16.57M	-564.43K	-25.70%
Jun 30, 2025	ECOR1 CAPITAL, LLC	2.07%	1.62M	16.42M	-1.8M	-52.66%
Jun 30, 2025	JPMORGAN CHASE & CO	1.71%	1.34M	13.55M	1.3M	+3,646.10%
Jun 30, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	1.36%	1.07M	10.81M	-344.86K	-24.45%
Jun 30, 2025	SIREN, L.L.C.	1.29%	1.01M	10.23M	0	0
Jun 30, 2025	CAPTION MANAGEMENT, LLC	1.28%	996.2K	10.11M	996.2K	+100.00%
Jun 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	1.22%	951.43K	9.66M	951.43K	+100.00%
Jun 30, 2025	ORBIMED ADVISORS LLC	1.15%	899.28K	9.13M	199.28K	+28.47%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.92%	714.87K	7.26M	-12.96K	-1.78%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.29%	223.3K	2.27M	45.09K	+25.30%
Jun 30, 2025	STEMPOINT CAPITAL LP	0.26%	200.79K	2.04M	200.79K	+100.00%
Jun 30, 2025	TD ASSET MANAGEMENT INC	0.23%	177.7K	1.8M	25K	+16.37%
Jun 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.19%	149.73K	1.52M	-6.92K	-4.42%
Jun 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	2.28%	1.78M	18.04M	-229.53K	-11.43%
Jun 30, 2025	ARROWMARK COLORADO HOLDINGS LLC	1.64%	1.28M	12.98M	-67.74K	-5.03%
Jun 30, 2025	FRANKLIN RESOURCES INC	1.33%	1.04M	10.58M	19.77K	+1.93%
Jun 30, 2025		9.17%	7.16M	72.7B	1.88M	+35.51%
Jun 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.22%	171.43K	1.74B	121.9K	+246.12%
Jun 30, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.17%	135.27K	1.37M	-106.73K	-44.10%
Jun 30, 2025	HRT FINANCIAL LP	0.13%	102.58K	1.04M	102.58K	+100.00%
Jun 30, 2025	ROYAL BANK OF CANADA	0.13%	99.9K	1.01M	95.07K	+1,966.59%
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	0.12%	91.21K	925.78K	-21.42K	-19.02%
Jun 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.11%	86.76K	880.56M	79.54K	+1,102.43%
Jun 30, 2025	FRED ALGER MANAGEMENT, LLC	0.1%	76.29K	774.3K	-102.44K	-57.32%
Jun 30, 2025	NICHOLAS INVESTMENT PARTNERS, LP	0.1%	74.24K	753.56K	-80.14K	-51.91%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.08%	63.81K	647.67M	-43.62K	-40.60%
Jun 30, 2025	UBS OCONNOR LLC	0.06%	49K	497.35K	1.36K	+2.85%
Jun 30, 2025	PALUMBO WEALTH MANAGEMENT LLC	0.06%	46.78K	474.85K	46.78K	+100.00%
Jun 30, 2025	COLUMN GROUP LLC	4.53%	3.54M	35.94M	0	0
Jun 30, 2025	VIVO CAPITAL, LLC	4%	3.13M	31.74M	1.05M	+50.29%
Jun 30, 2025	VR ADVISER, LLC	8.44%	6.6M	66.96M	3.41M	+107.28%
Jun 30, 2025	ATOM INVESTORS LP	0.32%	252.65K	2.56M	41.95K	+19.91%
Jun 30, 2025	WOODLINE PARTNERS LP	0.31%	244.37K	2.48M	244.37K	+100.00%
Jun 30, 2025	ROYCE & ASSOCIATES LP	0.3%	234.77K	2.38M	234.77K	+100.00%
Jun 30, 2025	BIOIMPACT CAPITAL LLC	2.21%	1.73M	17.55M	329.86K	+23.57%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.45%	350.54K	3.56M	296.55K	+549.34%
Jun 30, 2025	BARCLAYS PLC	0.18%	142.68K	1.45M	40.89K	+40.17%
Jun 30, 2025	VIKING GLOBAL INVESTORS LP	8.41%	6.57M	66.71M	0	0
Jun 30, 2025	PFIZER INC	6.88%	5.38M	54.57M	0	0
Jun 30, 2025	SR ONE CAPITAL MANAGEMENT, LP	5.78%	4.51M	45.83M	4.51M	+100.00%
Jun 30, 2025	INTEGRAL HEALTH ASSET MANAGEMENT, LLC	1.6%	1.25M	12.69M	1.25M	+100.00%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.42%	1.11M	11.25M	-197.53K	-15.13%
Jun 30, 2025	ALLY BRIDGE GROUP (NY) LLC	0.62%	485.63K	4.93M	485.63K	+100.00%
Jun 30, 2025	ALKEON CAPITAL MANAGEMENT LLC	5.77%	4.5M	45.72M	500K	+12.49%
Jun 30, 2025	VANGUARD GROUP INC	4%	3.12M	31.72M	-91.19K	-2.84%
Jun 30, 2025	CITADEL ADVISORS LLC	1.8%	1.4M	14.24B	890.88K	+174.04%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.63%	489.64K	4.97B	194.85K	+66.10%
Jun 30, 2025	MORGAN STANLEY	0.51%	394.79K	4.01B	226.11K	+134.06%
Jun 30, 2025	NEXTECH INVEST, LTD.	9.17%	7.16M	72.7B	1.88M	+35.51%
Mar 31, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.29%	203.01K	1.13M	203.01K	+100.00%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.42%	294.78K	1.64M	24.78K	+9.18%
Mar 31, 2025	NEA MANAGEMENT COMPANY, LLC	3.09%	2.2M	12.25M	629.46K	+40.19%
Mar 31, 2025	VR ADVISER, LLC	4.48%	3.18M	17.76M	-1.21M	-27.58%
Mar 31, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.34%	242K	1.35M	242K	+100.00%
Mar 31, 2025	NORTHERN TRUST CORP	0.77%	546.75K	3.05M	-7.25K	-1.31%
Mar 31, 2025	ORBIMED ADVISORS LLC	0.99%	700K	3.91M	700K	+100.00%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	1.02%	727.83K	4.06M	10.64K	+1.48%
Mar 31, 2025	FRANKLIN RESOURCES INC	1.44%	1.02M	5.71M	72.27K	+7.60%
Mar 31, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	2.9%	2.06M	11.5M	881.94K	+74.85%
Mar 31, 2025	VIVO CAPITAL, LLC	2.93%	2.08M	11.61M	802.63K	+62.81%
Mar 31, 2025	VANGUARD GROUP INC	4.53%	3.22M	17.94M	12.1K	+0.38%
Mar 31, 2025	ECOR1 CAPITAL, LLC	4.81%	3.42M	19.07M	0	0
Mar 31, 2025	COLUMN GROUP LLC	4.98%	3.54M	19.76M	0	0
Mar 31, 2025	ALKEON CAPITAL MANAGEMENT LLC	5.64%	4M	22.34M	100K	+2.56%
Mar 31, 2025	VIKING GLOBAL INVESTORS LP	9.25%	6.57M	36.68M	2.14M	+48.33%
Mar 31, 2025	TD ASSET MANAGEMENT INC	0.21%	152.7K	852.07K	4.9K	+3.32%
Mar 31, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.22%	156.64K	874.07K	-6.27K	-3.85%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.23%	166.15K	927.14K	-1.15K	-0.68%
Mar 31, 2025		0.24%	167.5K	934.66K	167.5K	+100.00%
Mar 31, 2025	FMR LLC	3.49%	2.48M	13.84M	12.61K	+0.51%
Mar 31, 2025	MORGAN STANLEY	0.24%	168.67K	941.18K	-178.68K	-51.44%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.25%	178.22K	994.45K	-8.21K	-4.41%
Mar 31, 2025	SPHERA FUNDS MANAGEMENT LTD.	0.33%	234.83K	1.31M	-38.38K	-14.05%
Mar 31, 2025	SUVRETTA CAPITAL MANAGEMENT, LLC	0.36%	255K	1.42M	255K	+100.00%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.37%	259.8K	1.45M	147.28K	+130.89%
Mar 31, 2025	SUPERSTRING CAPITAL MANAGEMENT LP	1.15%	819.19K	4.57M	-761.55K	-48.18%
Mar 31, 2025	EUCLIDEAN CAPITAL LLC	1.39%	989.41K	5.52M	0	0
Mar 31, 2025	ARROWMARK COLORADO HOLDINGS LLC	1.9%	1.35M	7.51M	-49.16K	-3.52%
Mar 31, 2025	SIREN, L.L.C.	1.42%	1.01M	5.62M	0	0
Mar 31, 2025	NICHOLAS INVESTMENT PARTNERS, LP	0.22%	154.38K	861.44K	154.38K	+100.00%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.84%	1.31M	7.29M	27.28K	+2.13%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	1.88%	1.33M	7.44M	37.84K	+2.92%
Mar 31, 2025	FIRST TURN MANAGEMENT, LLC	2.85%	2.03M	11.31M	576.39K	+39.72%
Mar 31, 2025	PFIZER INC	7.57%	5.38M	30M	0	0
Mar 31, 2025	BLACKROCK, INC.	7.65%	5.44M	30.33M	322.05K	+6.30%
Mar 31, 2025	ATOM INVESTORS LP	0.3%	210.71K	1.18M	134.06K	+174.92%
Mar 31, 2025	FRED ALGER MANAGEMENT, LLC	0.25%	178.72K	997.27K	-40.55K	-18.49%
Mar 31, 2025	CANTOR FITZGERALD, L. P.	0.28%	200K	1.12M	177.3K	+780.90%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.58%	408.51K	2.28M	-9.45K	-2.26%
Mar 31, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.6%	426.9K	2.38M	-297.42K	-41.06%
Mar 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.72%	509.18K	2.84M	473.6K	+1,331.12%
Mar 31, 2025	CITADEL ADVISORS LLC	0.72%	511.89K	2.86M	475.46K	+1,305.28%
Mar 31, 2025	BIOIMPACT CAPITAL LLC	1.97%	1.4M	7.81M	1.4M	+100.00%
Mar 31, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	1.99%	1.41M	7.87M	-2.48M	-63.73%
Mar 31, 2025	COMMODORE CAPITAL LP	2.82%	2M	11.16M	0	0
Mar 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	2.83%	2.01M	11.2M	452.01K	+29.06%
Mar 31, 2025	STATE STREET CORP	3.09%	2.2M	12.26M	350.29K	+18.97%
Mar 31, 2024	FMR LLC	9.77%	5.02M	69.09M	-1.98M	-28.24%
Mar 31, 2024	NEXTECH INVEST LTD.	10.27%	5.29M	72.68M	1M	+23.33%
Mar 31, 2024	METROPOLITAN LIFE INSURANCE CO/NY	0%	2.15K	29.55K	0	0
Mar 31, 2024	QUEST PARTNERS LLC	0.01%	2.94K	40.4K	2.94K	+100.00%
Mar 31, 2024	AMERITAS INVESTMENT PARTNERS, INC.	0.01%	3.22K	44.32M	0	0
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.01%	3.25K	44.73M	0	0
Mar 31, 2024	QUANTBOT TECHNOLOGIES LP	0.01%	5.7K	78.38K	5.7K	+100.00%
Mar 31, 2024	STRS OHIO	0.01%	7.4K	101K	-500	-6.33%
Mar 31, 2024	LPL FINANCIAL LLC	0.02%	10.29K	141.49K	290	+2.90%
Mar 31, 2024	PROSHARE ADVISORS LLC	0.02%	11.73K	161.33K	11.73K	+100.00%
Mar 31, 2024	BAIRD FINANCIAL GROUP, INC.	0.02%	12.34K	169.69K	0	0
Mar 31, 2024	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.03%	12.92K	178K	6.62K	+104.95%
Mar 31, 2024	CLEAR HARBOR ASSET MANAGEMENT, LLC	0.03%	13.74K	188.98K	13.74K	+100.00%
Mar 31, 2024	FIRST TURN MANAGEMENT, LLC	2.13%	1.1M	15.09M	1.1M	+100.00%
Mar 31, 2024	NEA MANAGEMENT COMPANY, LLC	2.92%	1.5M	20.63M	1.5M	+100.00%
Mar 31, 2024	ARROWMARK COLORADO HOLDINGS LLC	2.94%	1.51M	20.77M	-222.96K	-12.86%
Mar 31, 2024	PRICE T ROWE ASSOCIATES INC /MD/	3.05%	1.57M	21.54M	915.18K	+140.46%
Mar 31, 2024	STATE STREET CORP	3.34%	1.72M	23.6M	923.01K	+116.38%
Mar 31, 2024	BOXER CAPITAL, LLC	3.37%	1.73M	23.82M	0	0
Mar 31, 2024	COMMODORE CAPITAL LP	3.89%	2M	27.5M	2M	+100.00%
Mar 31, 2024	VANGUARD GROUP INC	5.6%	2.88M	39.63M	629.54K	+27.95%
Mar 31, 2024	BLACKROCK INC.	6.18%	3.18M	43.7M	82.54K	+2.67%
Mar 31, 2024	ECOR1 CAPITAL, LLC	6.64%	3.42M	47M	0	0
Mar 31, 2024	COLUMN GROUP LLC	6.88%	3.54M	48.69M	-27.4K	-0.77%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.2%	104.54K	1.44M	-2.06K	-1.93%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.21%	109.01K	1.5M	4K	+3.81%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.22%	115.09K	1.58M	-3.59K	-3.02%
Mar 31, 2024	INVUS FINANCIAL ADVISORS, LLC	1.96%	1.01M	13.85M	0	0
Mar 31, 2024	ADAGE CAPITAL PARTNERS GP, L.L.C.	2%	1.03M	14.17M	1.03M	+100.00%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.22%	110.9K	1.53M	-77.6K	-41.17%
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	0.22%	111.15K	1.53M	111.15K	+100.00%
Mar 31, 2024	WELLINGTON MANAGEMENT GROUP LLP	0.22%	111.97K	1.54M	39.58K	+54.67%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.24%	121.93K	1.68M	74.1K	+154.91%
Mar 31, 2024	MONACO ASSET MANAGEMENT SAM	0.25%	130K	1.79M	-150K	-53.57%
Mar 31, 2024	CITIGROUP INC	0.26%	133.91K	1.84M	127.34K	+1,940.32%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.26%	135.79K	1.87M	0	0
Mar 31, 2024	DRIEHAUS CAPITAL MANAGEMENT LLC	0.28%	143.94K	1.98M	0	0
Mar 31, 2024	WALLEYE CAPITAL LLC	0.29%	149.34K	2.05M	149.34K	+100.00%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	0.31%	160.8K	2.21M	136.13K	+551.65%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.33%	169.68K	2.33M	118.89K	+234.09%
Mar 31, 2024	NICHOLAS INVESTMENT PARTNERS, LP	0.36%	183.49K	2.52M	183.49K	+100.00%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	0.38%	196.85K	2.71M	196.85K	+100.00%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.39%	199.8K	2.75M	165.9K	+489.38%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.39%	201.12K	2.77M	95.43K	+90.29%
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.41%	208.6K	2.87M	127.8K	+158.17%
Mar 31, 2024	FRED ALGER MANAGEMENT, LLC	0.43%	219.94K	3.02M	219.94K	+100.00%
Mar 31, 2024	ORBIMED ADVISORS LLC	0.56%	287.1K	3.95M	-235.87K	-45.10%
Mar 31, 2024	MORGAN STANLEY	0.58%	300.82K	4.14M	-179.51K	-37.37%
Mar 31, 2024	NORTHERN TRUST CORP	0.69%	353.34K	4.86M	144	+0.04%
Mar 31, 2024	ALTIUM CAPITAL MANAGEMENT LP	0.79%	405K	5.57M	-271K	-40.09%
Mar 31, 2024	SOLEUS CAPITAL MANAGEMENT, L.P.	0.82%	421K	5.79M	421K	+100.00%
Mar 31, 2024	INVESCO LTD.	0.96%	494.17K	6.79M	124.95K	+33.84%
Mar 31, 2024	FRANKLIN RESOURCES INC	1.46%	750.52K	10.32M	0	0
Mar 31, 2024	VIVO CAPITAL, LLC	1.65%	849.68K	11.68M	0	0
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	1.77%	911.63K	12.54M	36.74K	+4.20%
Mar 31, 2024	EUCLIDEAN CAPITAL LLC	1.92%	989.41K	13.6M	0	0
Mar 31, 2024	SILVERARC CAPITAL MANAGEMENT, LLC	2.16%	1.11M	15.3M	-56.99K	-4.87%
Mar 31, 2024	VIKING GLOBAL INVESTORS LP	7.77%	4M	55M	4M	+100.00%
Mar 31, 2024	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	8.05%	4.14M	56.96M	2M	+93.33%
Mar 31, 2024	VR ADVISER, LLC	8.54%	4.39M	60.42M	1.97M	+80.97%
Mar 31, 2024	WELLS FARGO & COMPANY/MN	0.03%	15.22K	209.23K	1.79K	+13.30%
Mar 31, 2024	PROFUND ADVISORS LLC	0.03%	17.69K	243.18M	17.69K	+100.00%
Mar 31, 2024	AMERICAN INTERNATIONAL GROUP, INC.	0.04%	19.24K	264.5K	-165	-0.85%
Mar 31, 2024	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	20.74K	285.13K	0	0
Mar 31, 2024	LEGATO CAPITAL MANAGEMENT LLC	0.04%	23.1K	317.63K	23.1K	+100.00%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.06%	30.16K	414.7K	14.84K	+96.87%
Mar 31, 2024	JPMORGAN CHASE & CO	0.06%	31.8K	437.27K	-6.37K	-16.70%
Mar 31, 2024	RATAN CAPITAL MANAGEMENT LP	0.08%	40K	550K	40K	+100.00%
Mar 31, 2024	NEW YORK STATE COMMON RETIREMENT FUND	0.09%	44.71K	615K	35.14K	+367.23%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.1%	53.04K	729.34K	53.04K	+100.00%
Mar 31, 2024	RHUMBLINE ADVISERS	0.12%	60.3K	829.12K	2.4K	+4.14%
Mar 31, 2024	M&T BANK CORP	0.14%	71.41K	982.11K	-12.52K	-14.92%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.14%	73.17K	1.01M	23.62K	+47.66%
Mar 31, 2024	VICTORY CAPITAL MANAGEMENT INC	0.17%	88.54K	1.22M	-37.49K	-29.75%
Mar 31, 2024	UBS GROUP AG	0.18%	94.06K	1.29M	53.09K	+129.57%
Mar 31, 2024	CAMPBELL & CO INVESTMENT ADVISER LLC	0.19%	96.47K	1.33M	58.85K	+156.43%
Mar 31, 2024	ALKEON CAPITAL MANAGEMENT LLC	7.2%	3.7M	50.93M	100K	+2.77%
Dec 31, 2023	PRICE T ROWE ASSOCIATES INC /MD/	1.14%	651.56K	6M	606.45K	+1,344.22%
Dec 31, 2023	ORBIMED ADVISORS LLC	0.91%	522.97K	4.81M	-370.7K	-41.48%
Dec 31, 2023	POINT72 ASSET MANAGEMENT, L.P.	0.91%	521.14K	4.79M	521.14K	+100.00%
Dec 31, 2023	MORGAN STANLEY	0.84%	480.33K	4.42M	356.14K	+286.77%
Dec 31, 2023	INVESCO LTD.	0.64%	369.22K	3.4M	27.69K	+8.11%
Dec 31, 2023	NORTHERN TRUST CORP	0.62%	353.2K	3.25M	10.3K	+3.00%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.18%	105.69K	972.35K	-27.42K	-20.60%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.19%	106.6K	980.73K	719	+0.68%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.21%	118.68K	1.09M	4.03K	+3.51%
Dec 31, 2023	VICTORY CAPITAL MANAGEMENT INC	0.22%	126.03K	1.16M	1.18K	+0.95%
Dec 31, 2023	SPHERA FUNDS MANAGEMENT LTD.	0.22%	126.8K	1.17M	126.8K	+100.00%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.24%	135.79K	1.25M	-33.23K	-19.66%
Dec 31, 2023	DRIEHAUS CAPITAL MANAGEMENT LLC	0.25%	143.94K	1.32M	0	0
Dec 31, 2023	RENAISSANCE TECHNOLOGIES LLC	0.33%	188.5K	1.73M	-191.3K	-50.37%
Dec 31, 2023	CAPTION MANAGEMENT, LLC	0.17%	95.26K	876.39K	95.26K	+100.00%
Dec 31, 2023	UBS OCONNOR LLC	0.46%	262.96K	2.42M	-88.55K	-25.19%
Dec 31, 2023	BOXER CAPITAL, LLC	3.02%	1.73M	15.94M	0	0
Dec 31, 2023	ARROWMARK COLORADO HOLDINGS LLC	3.02%	1.73M	15.95M	83.86K	+5.08%
Dec 31, 2023	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	3.73%	2.14M	19.71M	0	0
Dec 31, 2023	VANGUARD GROUP INC	3.92%	2.25M	20.72M	-336.35K	-12.99%
Dec 31, 2023	VR ADVISER, LLC	4.23%	2.43M	22.34M	285.53K	+13.32%
Dec 31, 2023	PROSIGHT MANAGEMENT, LP	2.75%	1.58M	14.52M	-1M	-38.82%
Dec 31, 2023	BLACKROCK INC.	5.39%	3.1M	28.48M	-636.96K	-17.06%
Dec 31, 2023	ECOR1 CAPITAL, LLC	5.95%	3.42M	31.45M	0	0
Dec 31, 2023	COLUMN GROUP LLC	6.22%	3.57M	32.83M	0	0
Dec 31, 2023	ALKEON CAPITAL MANAGEMENT LLC	6.28%	3.6M	33.16M	124.81K	+3.59%
Dec 31, 2023	NEXTECH INVEST LTD.	7.47%	4.29M	39.43M	0	0
Dec 31, 2023	FMR LLC	12.2%	7M	64.42M	3.87M	+123.55%
Dec 31, 2023	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.08%	47.83K	440.05K	31.45K	+191.96%
Dec 31, 2023	AMERICAN CENTURY COMPANIES INC	0.09%	49.55K	455.86K	17.11K	+52.76%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.09%	50.79K	467.25K	2.63K	+5.47%
Dec 31, 2023	BARCLAYS PLC	0.09%	54.2K	499K	46.48K	+602.51%
Dec 31, 2023	MONACO ASSET MANAGEMENT SAM	0.49%	280K	2.58M	-104.79K	-27.23%
Dec 31, 2023	RHUMBLINE ADVISERS	0.1%	57.9K	532.71K	-677	-1.16%
Dec 31, 2023	WELLINGTON MANAGEMENT GROUP LLP	0.13%	72.4K	666.05K	72.4K	+100.00%
Dec 31, 2023	DAFNA CAPITAL MANAGEMENT LLC	0.13%	72.8K	669.73K	72.8K	+100.00%
Dec 31, 2023	TD ASSET MANAGEMENT INC	0.14%	80.8K	743.36K	80.8K	+100.00%
Dec 31, 2023	M&T BANK CORP	0.15%	83.93K	771.83K	12.96K	+18.27%
Dec 31, 2023	D. E. SHAW & CO., INC.	0.17%	98.43K	905.58K	-209.05K	-67.99%
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	0.18%	105.01K	966.09K	73.9K	+237.50%
Dec 31, 2023	SILVERARC CAPITAL MANAGEMENT, LLC	2.04%	1.17M	10.76M	46.66K	+4.15%
Dec 31, 2023	INVUS FINANCIAL ADVISORS, LLC	1.76%	1.01M	9.27M	0	0
Dec 31, 2023	EUCLIDEAN CAPITAL LLC	1.72%	989.41K	9.1M	0	0
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.52%	874.89K	8.05M	54.44K	+6.64%
Dec 31, 2023	VIVO CAPITAL, LLC	1.48%	849.68K	7.82M	71.74K	+9.22%
Dec 31, 2023	STATE STREET CORP	1.38%	793.07K	7.3M	74.06K	+10.30%
Dec 31, 2023	FRANKLIN RESOURCES INC	1.31%	750.52K	6.9M	105	+0.01%
Dec 31, 2023	ALTIUM CAPITAL MANAGEMENT LP	1.18%	676K	6.22M	257.29K	+61.45%
Dec 31, 2023	JANUS HENDERSON GROUP PLC	1.15%	659.05K	6.07M	659.05K	+100.00%

Insiders

Among the ORIC insiders holding of 6.94% of the stake in company, ORBIMED ADVISORS LLC, director, holds the largest shares of 2.21M. GORDON CARL L, director, is the second largest ORIC insider with ownership of 2.21M shares. TOPSPIN FUND L.P., 10 percent owner, stands third with possession of 1.1M shares of that stake.

Insiders	Designation	Shares Held
ORBIMED ADVISORS LLC	director	2.21M
GORDON CARL L	director	2.21M
TOPSPIN FUND L.P.	10 percent owner	1.1M
CHACKO JACOB	PRESIDENT AND CEO	581.71K
MULTANI PRATIK S	Chief Medical Officer	68.15K
PISCITELLI DOMINIC	Chief Financial Officer	68.15K
HEYMAN RICHARD A.	director	41.8K
SCHELLER RICHARD H	director	39.09K
YOU ANGIE	director	28K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Jan 16, 2026	HEYMAN RICHARD A.	SALE	12.00	3.5K	42.02K	41.8K
Dec 16, 2025	PISCITELLI DOMINIC	SALE	9.06	10.72K	97.13K	68.15K
Dec 16, 2025	CHACKO JACOB	SALE	9.06	33.37K	302.37K	581.71K
Dec 16, 2025	MULTANI PRATIK S	SALE	9.06	10.72K	97.13K	68.15K
Oct 06, 2025	PISCITELLI DOMINIC	SALE	14.52	11K	159.72K	48.32K
Oct 06, 2025	CHACKO JACOB	SALE	12.32	37.46K	461.52K	531.42K
Oct 01, 2025	CHACKO JACOB	SALE	12.05	53K	638.81K	568.88K
Sep 30, 2025	CHACKO JACOB	SALE	12.01	34.54K	414.75K	621.88K
Sep 22, 2025	CHACKO JACOB	SALE	10.80	125K	1.35M	656.42K
Jul 01, 2025	PISCITELLI DOMINIC	SALE	10.05	20K	200.97K	48.32K
Jun 24, 2025	PISCITELLI DOMINIC	SALE	10.50	32.47K	341.04K	68.32K
Jun 23, 2025	PISCITELLI DOMINIC	SALE	10.01	450	4.5K	100.78K
Jun 23, 2025	YOU ANGIE	PURCHASE	9.43	1.4K	13.23K	28K
Jun 20, 2025	YOU ANGIE	PURCHASE	9.39	26.6K	249.67K	26.6K
Jun 12, 2025	PISCITELLI DOMINIC	SALE	10.00	300	3K	101.82K
Jun 11, 2025	PISCITELLI DOMINIC	SALE	10.01	1.7K	17.02K	102.12K
Jun 10, 2025	PISCITELLI DOMINIC	SALE	10.00	324	3.24K	105.09K
Jun 09, 2025	PISCITELLI DOMINIC	SALE	10.00	300	3K	103.86K
Jun 06, 2025	PISCITELLI DOMINIC	SALE	10.01	2.6K	26.02K	104.16K
Dec 16, 2024	CHACKO JACOB	SALE	8.28	24.66K	204.21K	778.65K
Dec 16, 2024	PISCITELLI DOMINIC	SALE	8.28	8.85K	73.3K	106.76K
Dec 16, 2024	MULTANI PRATIK S	SALE	8.28	8.85K	73.29K	46.77K
Mar 06, 2024	CHACKO JACOB	SALE	16.21	40K	648.38K	728.54K
Feb 07, 2024	CHACKO JACOB	SALE	12.29	26.04K	320.19K	768.54K
Feb 06, 2024	CHACKO JACOB	SALE	12.12	13.96K	169.16K	794.59K
Dec 15, 2023	CHACKO JACOB	SALE	8.58	14.54K	124.81K	808.54K
Dec 15, 2023	PISCITELLI DOMINIC	SALE	8.58	5.28K	45.34K	83.81K
Dec 15, 2023	MULTANI PRATIK S	SALE	8.59	5.28K	45.35K	23.81K
Jul 11, 2023	CHACKO JACOB	SALE	8.01	5.16K	41.29K	780.65K
Jul 10, 2023	CHACKO JACOB	SALE	8.01	10.51K	84.21K	785.81K
Jul 05, 2023	CHACKO JACOB	SALE	8.01	4.34K	34.71K	796.32K
Jun 26, 2023	CHACKO JACOB	SALE	8.03	20K	160.56K	800.65K
Dec 15, 2022	MULTANI PRATIK S	SALE	3.25	2.09K	6.79K	7.42K
Dec 15, 2022	PISCITELLI DOMINIC	SALE	3.25	2.09K	6.79K	67.42K
Dec 15, 2022	CHACKO JACOB	SALE	3.25	5.76K	18.73K	817.03K
May 13, 2022	CHACKO JACOB	PURCHASE	2.82	76.07K	214.56K	802.65K
May 12, 2022	CHACKO JACOB	PURCHASE	2.75	69.35K	190.47K	726.58K
May 11, 2022	CHACKO JACOB	PURCHASE	2.90	304.57K	883.57K	657.23K
Mar 31, 2022	PISCITELLI DOMINIC	PURCHASE	5.36	60K	321.62K	60K
Mar 25, 2022	CHACKO JACOB	PURCHASE	4.54	50K	227.17K	352.65K
Mar 23, 2022	CHACKO JACOB	PURCHASE	4.98	257.13K	1.28M	259.78K
Sep 15, 2021	CHACKO JACOB	SALE	25.06	3.74K	93.63K	2.65K
Sep 15, 2021	HEYMAN RICHARD A.	SALE	25.03	682	17.07K	216.27K
Sep 14, 2021	CHACKO JACOB	SALE	25.05	4.42K	110.71K	6.39K
Sep 14, 2021	HEYMAN RICHARD A.	SALE	25.05	706	17.69K	216.95K
Sep 13, 2021	CHACKO JACOB	SALE	25.02	2.8K	70.09K	10.81K
Sep 13, 2021	HEYMAN RICHARD A.	SALE	25.01	601	15.03K	217.66K
Sep 10, 2021	HEYMAN RICHARD A.	SALE	25.10	479	12.02K	218.26K
Sep 10, 2021	CHACKO JACOB	SALE	25.08	2.94K	73.78K	13.61K
Sep 08, 2021	CHACKO JACOB	SALE	25.04	200	5.01K	16.55K
Sep 07, 2021	HEYMAN RICHARD A.	SALE	25.11	1.09K	27.27K	218.74K
Sep 07, 2021	CHACKO JACOB	SALE	25.11	5.98K	150.17K	16.75K
May 27, 2021	CHACKO JACOB	SALE	25.07	400	10.03K	22.73K
May 24, 2021	HEYMAN RICHARD A.	SALE	25.00	100	2.5K	219.83K
May 24, 2021	SCHELLER RICHARD H	SALE	25.00	100	2.5K	39.09K
May 24, 2021	CHACKO JACOB	SALE	25.00	12	300	23.13K
May 21, 2021	SCHELLER RICHARD H	SALE	25.19	1.23K	31.01K	39.19K
May 21, 2021	HEYMAN RICHARD A.	SALE	25.25	600	15.15K	219.93K
May 21, 2021	CHACKO JACOB	SALE	25.20	4.79K	120.69K	23.14K
May 20, 2021	CHACKO JACOB	SALE	25.07	2.47K	61.86K	27.93K
May 20, 2021	SCHELLER RICHARD H	SALE	25.08	659	16.53K	40.42K
May 20, 2021	HEYMAN RICHARD A.	SALE	25.08	700	17.56K	220.53K
May 18, 2021	CHACKO JACOB	SALE	26.03	200	5.21K	30.4K
May 18, 2021	HEYMAN RICHARD A.	SALE	25.32	2.16K	54.72K	221.23K
May 18, 2021	SCHELLER RICHARD H	SALE	25.34	2.8K	70.96K	41.08K
May 17, 2021	CHACKO JACOB	SALE	25.05	2.55K	63.88K	41.73K
May 17, 2021	HEYMAN RICHARD A.	SALE	25.07	498	12.48K	223.39K
May 17, 2021	SCHELLER RICHARD H	SALE	25.06	500	12.53K	43.88K
May 14, 2021	SCHELLER RICHARD H	SALE	25.38	4.62K	117.12K	44.38K
May 14, 2021	HEYMAN RICHARD A.	SALE	25.31	3.22K	81.38K	223.89K
May 14, 2021	CHACKO JACOB	SALE	25.36	13.9K	352.47K	44.28K
May 13, 2021	SCHELLER RICHARD H	SALE	25.00	100	2.5K	49K
May 13, 2021	CHACKO JACOB	SALE	25.04	730	18.28K	58.18K
May 12, 2021	SCHELLER RICHARD H	SALE	25.00	103	2.58K	49.1K
May 12, 2021	CHACKO JACOB	SALE	25.02	400	10.01K	58.91K
May 11, 2021	SCHELLER RICHARD H	SALE	25.16	300	7.55K	49.2K
May 11, 2021	HEYMAN RICHARD A.	SALE	25.11	100	2.51K	227.1K
May 11, 2021	CHACKO JACOB	SALE	25.22	1.09K	27.49K	59.31K
Apr 30, 2021	SCHELLER RICHARD H	SALE	25.19	100	2.52K	49.5K
Apr 30, 2021	CHACKO JACOB	SALE	25.24	600	15.14K	60.4K
Apr 30, 2021	HEYMAN RICHARD A.	SALE	25.26	100	2.53K	227.2K
Apr 28, 2021	CHACKO JACOB	SALE	25.06	700	17.54K	61K
Apr 28, 2021	HEYMAN RICHARD A.	SALE	25.08	100	2.51K	227.3K
Apr 28, 2021	SCHELLER RICHARD H	SALE	25.11	200	5.02K	49.6K
Apr 01, 2021	CHACKO JACOB	SALE	25.09	800	20.07K	61.7K
Apr 01, 2021	SCHELLER RICHARD H	SALE	25.00	200	5K	49.8K
Apr 01, 2021	HEYMAN RICHARD A.	SALE	25.00	100	2.5K	227.4K
Mar 30, 2021	GORDON CARL L	SALE	23.93	27.87K	666.91K	2.21M
Mar 30, 2021	ORBIMED ADVISORS LLC	SALE	23.93	27.87K	666.91K	2.21M
Mar 29, 2021	GORDON CARL L	SALE	23.31	75.56K	1.76M	2.24M
Mar 29, 2021	ORBIMED ADVISORS LLC	SALE	23.31	75.56K	1.76M	2.24M
Mar 26, 2021	GORDON CARL L	SALE	23.88	27.82K	664.25K	2.32M
Mar 26, 2021	ORBIMED ADVISORS LLC	SALE	23.88	27.82K	664.25K	2.32M
Mar 25, 2021	GORDON CARL L	SALE	24.70	51.52K	1.27M	2.34M
Mar 25, 2021	ORBIMED ADVISORS LLC	SALE	24.70	51.52K	1.27M	2.34M
Mar 24, 2021	GORDON CARL L	SALE	24.80	32.96K	817.38K	2.4M
Mar 24, 2021	ORBIMED ADVISORS LLC	SALE	24.80	32.96K	817.38K	2.4M
Mar 23, 2021	GORDON CARL L	SALE	24.32	3.99K	97.09K	2.43M
Mar 23, 2021	ORBIMED ADVISORS LLC	SALE	24.32	3.99K	97.09K	2.43M
Mar 22, 2021	ORBIMED ADVISORS LLC	SALE	26.47	7.67K	203.1K	2.43M
Mar 22, 2021	GORDON CARL L	SALE	26.47	7.67K	203.1K	2.43M
Mar 19, 2021	ORBIMED ADVISORS LLC	SALE	26.47	21.28K	563.15K	2.44M
Mar 19, 2021	GORDON CARL L	SALE	26.47	21.28K	563.15K	2.44M
Mar 18, 2021	ORBIMED ADVISORS LLC	SALE	28.03	6.06K	169.83K	2.46M
Mar 18, 2021	GORDON CARL L	SALE	28.03	6.06K	169.83K	2.46M
Mar 17, 2021	ORBIMED ADVISORS LLC	SALE	28.43	18.79K	534.2K	2.47M
Mar 17, 2021	GORDON CARL L	SALE	28.43	18.79K	534.2K	2.47M
Mar 16, 2021	ORBIMED ADVISORS LLC	SALE	27.72	41.35K	1.15M	2.49M
Mar 16, 2021	GORDON CARL L	SALE	27.72	41.35K	1.15M	2.49M
Mar 15, 2021	ORBIMED ADVISORS LLC	SALE	29.14	89.21K	2.6M	2.53M
Mar 15, 2021	GORDON CARL L	SALE	29.14	89.21K	2.6M	2.53M
Mar 12, 2021	GORDON CARL L	SALE	30.29	90.52K	2.74M	2.62M
Mar 12, 2021	ORBIMED ADVISORS LLC	SALE	30.29	90.52K	2.74M	2.62M
Mar 11, 2021	ORBIMED ADVISORS LLC	SALE	33.04	58.55K	1.93M	2.71M
Mar 11, 2021	GORDON CARL L	SALE	33.04	58.55K	1.93M	2.71M
Nov 04, 2020	TOPSPIN FUND L.P.	SALE	0.00	2.27M	-	1.1M
Apr 24, 2020	ORBIMED ADVISORS LLC	PURCHASE	16.00	281.25K	4.5M	281.25K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES319.31K9

NET SHARES-319.31K9

SHARES HELD3.19M9

% NET SHARES-110.02%0%

Frequently Asked Questions