How many institutions own MIRM stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own MIRM shares is 299, representing 114.07% of the company's common stock.

Who are the major shareholders selling Mirum Pharmaceuticals, Inc. stock?

MILLENNIUM MANAGEMENT LLC, in the last quarter, reduced its stake in MIRM by -20.96% restricting it's holding to 244.27 thousand shares of worth nearly $19.30M. ADAGE CAPITAL PARTNERS GP, L.L.C. also lessened -6.03% of the MIRM shares from its portfolio, reducing its holding to 467.47 thousand shares of worth $36.93M. POLAR CAPITAL HOLDINGS PLC also shunned MIRM shares holding by -3.28% last quarter which brought its holding to 793.64 thousand shares worth $62.69M.

Investors who are buying MIRM stock?

As per its latest 13F filing, FRANKLIN RESOURCES INC increased its stake in MIRM by 8.25% in the last quarter. The institutional holder raised its holding to 650.72 thousand shares having worth more than $51.40M. BANK OF NEW YORK MELLON CORP also added 26.95% more shares of MIRM to its portfolio, raising its holding to 565.58 thousand shares of worth $44.68M. FMR LLC also increased its MIRM shares holding by 0.98% which brought its holding to 646.47 thousand shares worth $51.06M.

MIRM's major insiders: who are they?

The insider with the most stakes in MIRM is New Enterprise Associates 16, L.P. , 10 percent owner at the company. Additionally, MIRM stock is highly held by 10 percent owner Walker Paul Edward and 10 percent owner Sonsini Peter W. among others.

Did an insider recently sell MIRM stock?

Company executives, directors, and other insiders own 1.86% percent of Mirum Pharmaceuticals, Inc.'s stock. Within the last six months, there have been 22 transaction(s) in which MIRM insiders have sold stock, totaling 216.21K shares. Insiders that have sold shares include RAMASASTRY SAIRA, HOWE JOLANDA, and PEETZ CHRISTOPHER.

Which insider recently purchased MIRM stock?

There have been 1 transaction(s) during the past 6-months in which Mirum Pharmaceuticals, Inc. insiders have bought stock, totalling 131425 shares

How much of MIRM does insiders own?

Around 1.19M Mirum Pharmaceuticals, Inc. shares are held by insiders, which represents about 1.86% of MIRM stock.

Who is the insider with the largest stake?

MIRM 10 percent owner, New Enterprise Associates 16, L.P. holds the largest portfolio of the company's shares. MIRM shares owned by New total nearly 4.19 million.

Which institution holds the most shares in MIRM?

BVF INC/IL is the largest institutional owner in MIRM which holds 1.5 million shares worth $118.11M or 2.57% of the total MIRM shares outstanding followed by MILLENNIUM MANAGEMENT LLC with ownership of 244.27 thousand shares representing 0.42% of the MIRM ownership. FRANKLIN RESOURCES INC is the third largest stakeholder with 650.72 thousand shares or 1.12% of the ownership worth more than $51.40M.

Is Mirum Pharmaceuticals, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the MIRM is concerned, it is a stock which is optionable.

Is there a short position on MIRM's shares?

Number of MIRM shares short is 6.63M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding MIRM shares are there?

As of today, 50.24M shares of MIRM are outstanding.

Is there many float in MIRM stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, MIRM has 39.99M shares in float.

MIRM short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for MIRM is 17.23.

Mirum Pharmaceuticals (MIRM) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares13.25

Short Percent Of Float13.25

Shares Outstanding50.24M

Shares Float39.99M

Shares Short6.63M

Short Ratio17.23

13.25%

Short % of Float

13.25%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

1.86% Percentage of Shares held by All Insiders

114.07% Percentage of Shares held by All Institutions

116.24% Percentage of Float held by Institutions

299

Number of Institutions Holding Shares

Institutional Ownership

About 114.07% of MIRM shares are held by financial institutions. BVF INC/IL is the top corporate investor, holding 1.5M shares valued at $118.11M. A 2.57% stake in Mirum Pharmaceuticals, Inc. is owned by the company. MILLENNIUM MANAGEMENT LLC owns 244.27K shares valued at $19.30M, which translates its holding of 0.42% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	BVF INC/IL	2.57%	1.5M	118.11M	0	0
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	0.42%	244.27K	19.3M	-64.76K	-20.96%
Dec 31, 2025	FRANKLIN RESOURCES INC	1.12%	650.72K	51.4M	49.58K	+8.25%
Dec 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.8%	467.47K	36.93M	-30K	-6.03%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.97%	565.58K	44.68M	120.05K	+26.95%
Dec 31, 2025	WOODLINE PARTNERS LP	0.98%	567.89K	44.86M	0	0
Dec 31, 2025	FMR LLC	1.11%	646.47K	51.06M	6.25K	+0.98%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	1.13%	655.78K	51.8M	54.71K	+9.10%
Dec 31, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	1.31%	762.29K	60.21M	1.17K	+0.15%
Dec 31, 2025	POLAR CAPITAL HOLDINGS PLC	1.37%	793.64K	62.69M	-26.91K	-3.28%
Dec 31, 2025	D. E. SHAW & CO., INC.	1.63%	948.16K	74.9M	24.65K	+2.67%
Dec 31, 2025	NOVO HOLDINGS A/S	2.18%	1.26M	99.85M	0	0
Dec 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.44%	1.42M	112.2M	137.09K	+10.68%
Dec 31, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	11.7%	6.8M	536.75M	0	0
Dec 31, 2025	ESSEX INVESTMENT MANAGEMENT CO LLC	0.19%	111.31K	8.79M	-2.15K	-1.89%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.2%	115.44K	9.12M	88.37K	+326.52%
Dec 31, 2025	HIGHLANDER PARTNERS, L.P.	0.21%	122.98K	9.71M	0	0
Dec 31, 2025	ENSIGN PEAK ADVISORS, INC	0.23%	133.97K	10.58M	0	0
Dec 31, 2025	FIRST TRUST ADVISORS LP	0.24%	137.7K	10.88M	-6.55K	-4.54%
Dec 31, 2025	BARCLAYS PLC	0.24%	142.14K	11.23M	26.37K	+22.78%
Dec 31, 2025	CITIGROUP INC	0.25%	145.99K	11.53M	-1.26K	-0.86%
Dec 31, 2025	LEGAL & GENERAL GROUP PLC	0.29%	168.39K	13.3M	1.16K	+0.70%
Dec 31, 2025	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	0.44%	257.23K	20.32M	257.23K	+100.00%
Dec 31, 2025	NORGES BANK	0.45%	263.18K	20.79M	263.18K	+100.00%
Dec 31, 2025	PENN CAPITAL MANAGEMENT COMPANY, LLC	0.49%	281.92K	22.32M	-26.07K	-8.47%
Dec 31, 2025	TANG CAPITAL MANAGEMENT LLC	2.13%	1.24M	97.63M	0	0
Dec 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	2.13%	1.24M	97.78M	447.14K	+56.55%
Dec 31, 2025	JANUS HENDERSON GROUP PLC	10.44%	6.07M	479.05M	1.07M	+21.36%
Dec 31, 2025	UBS GROUP AG	0.55%	320.78K	25.34M	44.94K	+16.29%
Dec 31, 2025	WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	0.58%	336.7K	26.6M	23.44K	+7.48%
Dec 31, 2025	EMERALD ADVISERS, LLC	0.63%	367.13K	29M	-2.47K	-0.67%
Dec 31, 2025	NEXT CENTURY GROWTH INVESTORS LLC	0.63%	368.04K	29.07M	7.1K	+1.97%
Dec 31, 2025	TWO SIGMA INVESTMENTS, LP	0.67%	388.54K	30.69M	45.42K	+13.24%
Dec 31, 2025	TIMESSQUARE CAPITAL MANAGEMENT, LLC	0.68%	395.83K	31.27M	95.18K	+31.66%
Dec 31, 2025	NUVEEN, LLC	0.87%	503.05K	39.74M	-98.63K	-16.39%
Dec 31, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.99%	573.61K	45.31M	424.92K	+285.76%
Dec 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.99%	577.27K	45.6M	36K	+6.65%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	1.23%	713.45K	56.36M	322.98K	+82.71%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	1.25%	724.32K	57.21M	273.48K	+60.66%
Dec 31, 2025	CITADEL ADVISORS LLC	1.45%	840.22K	66.37M	-200.32K	-19.25%
Dec 31, 2025	EVENTIDE ASSET MANAGEMENT, LLC	3.6%	2.09M	165.37M	-428.98K	-17.01%
Dec 31, 2025	STATE STREET CORP	3.69%	2.14M	169.35M	797.09K	+59.18%
Dec 31, 2025	VANGUARD GROUP INC	4.47%	2.6M	205.07M	50.72K	+1.99%
Dec 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.49%	285.87K	22.58M	-31.28K	-9.86%
Dec 31, 2025	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.51%	297.95K	23.54M	-91.62K	-23.52%
Dec 31, 2025	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	0.64%	372.51K	29.42M	-239.81K	-39.16%
Dec 31, 2025	NORTHERN TRUST CORP	0.65%	374.86K	29.61M	-10.47K	-2.72%
Dec 31, 2025	BOONE CAPITAL MANAGEMENT LLC	0.72%	421.24K	33.27M	-114.5K	-21.37%
Dec 31, 2025	MACQUARIE MANAGEMENT HOLDINGS, INC.	0.73%	421.85K	33.32B	421.85K	+100.00%
Dec 31, 2025	MORGAN STANLEY	0.73%	425.69K	33.62M	-244.46K	-36.48%
Dec 31, 2025	SQUAREPOINT OPS LLC	0.3%	172.43K	13.62M	44.52K	+34.81%
Dec 31, 2025	SEGALL BRYANT & HAMILL, LLC	0.32%	185.02K	14.62M	185.02K	+100.00%
Dec 31, 2025	DEUTSCHE BANK AG\	0.32%	186.71K	14.75M	2.38K	+1.29%
Dec 31, 2025	NICHOLAS INVESTMENT PARTNERS, LP	0.37%	213.39K	16.86M	-3.68K	-1.69%
Dec 31, 2025	HANDELSBANKEN FONDER AB	0.37%	213.5K	16.86M	213.5K	+100.00%
Dec 31, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.37%	217.61K	17.19M	-25.78K	-10.59%
Dec 31, 2025	LOGOS GLOBAL MANAGEMENT LP	0.39%	225K	17.77M	225K	+100.00%
Dec 31, 2025	NAN FUNG TRINITY (HK) LTD	0.39%	227.48K	17.97M	71.21K	+45.57%
Dec 31, 2025	TWO SIGMA ADVISERS, LP	0.4%	232.1K	18.33M	-44.3K	-16.03%
Dec 31, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.42%	242.32K	19.14M	23.28K	+10.63%
Dec 31, 2025	RAYMOND JAMES FINANCIAL INC	0.42%	246.42K	19.46M	-5.32K	-2.11%
Dec 31, 2025	ERSTE ASSET MANAGEMENT GMBH	0.43%	250K	19.78M	0	0
Dec 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.76%	439.09K	34.68M	-74.36K	-14.48%
Dec 31, 2025	PATIENT SQUARE CAPITAL LP	0.51%	298.68K	23.59M	194.42K	+186.47%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.7%	409.29K	32.33M	14.8K	+3.75%
Dec 31, 2025	FIRST TURN MANAGEMENT, LLC	0.83%	481.56K	38.04M	-89.01K	-15.60%
Dec 31, 2025	FEDERATED HERMES, INC.	0.83%	481.96K	38.07M	135.44K	+39.09%
Dec 31, 2025	LOOMIS SAYLES & CO L P	0.89%	514.98K	40.68M	-24.06K	-4.46%
Dec 31, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.9%	521.65K	41.21M	25.68K	+5.18%
Dec 31, 2025	CANDRIAM S.C.A.	0.98%	569.59K	44.99M	166.56K	+41.33%
Dec 31, 2025	LORD, ABBETT & CO. LLC	1%	579.98K	45.81M	-81.96K	-12.38%
Dec 31, 2025	CLEARBRIDGE INVESTMENTS, LLC	1.49%	865.97K	68.4M	-137.84K	-13.73%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.83%	1.06M	83.98M	52.9K	+5.24%
Dec 31, 2025	BLACKROCK, INC.	6.27%	3.65M	287.94M	42.85K	+1.19%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.49%	243.39K	17.84M	-6.47K	-2.59%
Sep 30, 2025	BVF INC/IL	2.57%	1.5M	109.62M	-1.27M	-45.85%
Sep 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	4.34%	2.52M	184.92M	-114.92K	-4.36%
Sep 30, 2025	VANGUARD GROUP INC	4.38%	2.55M	186.6M	-19.5K	-0.76%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.53%	309.03K	22.66M	20.87K	+7.24%
Sep 30, 2025	NEXT CENTURY GROWTH INVESTORS LLC	0.62%	360.93K	26.46M	170.61K	+89.64%
Sep 30, 2025	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.67%	389.57K	28.56M	372K	+2,116.64%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.77%	445.53K	32.66M	-50.53K	-10.19%
Sep 30, 2025	CALAMOS ADVISORS LLC	0.09%	43.25K	3.17M	9.99K	+30.02%
Sep 30, 2025	SECURE ASSET MANAGEMENT, LLC	0.1%	48.44K	3.54M	-2.56K	-5.01%
Sep 30, 2025	JANUS HENDERSON GROUP PLC	8.6%	5M	366.52M	-238.69K	-4.56%
Sep 30, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	11.7%	6.8M	498.15M	0	0
Sep 30, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.85%	495.98K	36.36M	72.23K	+17.05%
Sep 30, 2025	PRUDENTIAL FINANCIAL INC	0.11%	54.19K	3.97M	44.54K	+461.79%
Sep 30, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.11%	56.26K	4.12M	-9.5K	-14.45%
Sep 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.93%	541.28K	39.68M	-159.88K	-22.80%
Sep 30, 2025	NOVO HOLDINGS A/S	2.18%	1.26M	92.67M	-236.03K	-15.73%
Sep 30, 2025	NORTHERN TRUST CORP	0.66%	385.34K	28.25M	-17.06K	-4.24%
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.59%	343.13K	25.15M	171.31K	+99.71%
Sep 30, 2025	CITADEL ADVISORS LLC	1.79%	1.04M	76.28M	-365.81K	-26.01%
Sep 30, 2025	TANG CAPITAL MANAGEMENT LLC	2.13%	1.24M	90.61M	0	0
Sep 30, 2025	STATE STREET CORP	2.32%	1.35M	98.74M	-28.72K	-2.09%
Sep 30, 2025	BOONE CAPITAL MANAGEMENT LLC	0.92%	535.73K	39.27M	-105.72K	-16.48%
Sep 30, 2025	BANK OF MONTREAL /CAN/	0.11%	57.04K	4.18M	0	0
Sep 30, 2025	RHUMBLINE ADVISERS	0.12%	59.07K	4.33M	-5.53K	-8.56%
Sep 30, 2025	SWISS NATIONAL BANK	0.14%	72K	5.28M	1.8K	+2.56%
Sep 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.16%	78.9K	5.78M	12.11K	+18.13%
Sep 30, 2025	HEALTHINVEST PARTNERS AB	0.19%	93.61K	728.52K	-13.31K	-12.45%
Sep 30, 2025	JPMORGAN CHASE & CO	0.2%	100.21K	7.35M	-380.07K	-79.14%
Sep 30, 2025	INVESCO LTD.	0.2%	101.47K	7.44M	36.82K	+56.95%
Sep 30, 2025	PATIENT SQUARE CAPITAL LP	0.21%	104.26K	7.64M	-9.2K	-8.11%
Sep 30, 2025	ESSEX INVESTMENT MANAGEMENT CO LLC	0.23%	113.46K	8.32M	727	+0.64%
Sep 30, 2025	BARCLAYS PLC	0.23%	115.77K	8.49M	-39.1K	-25.25%
Sep 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.23%	115.85K	8.49M	-6.92K	-5.63%
Sep 30, 2025	HIGHLANDER PARTNERS, L.P.	0.25%	122.98K	9.02M	0	0
Sep 30, 2025	ENSIGN PEAK ADVISORS, INC	0.27%	133.97K	9.82M	0	0
Sep 30, 2025	FIRST TRUST ADVISORS LP	0.29%	144.25K	10.57M	14.45K	+11.14%
Sep 30, 2025	CITIGROUP INC	0.3%	147.25K	10.8M	76.55K	+108.26%
Sep 30, 2025	NAN FUNG TRINITY (HK) LTD	0.31%	156.27K	11.46M	9.5K	+6.47%
Sep 30, 2025	JUMP FINANCIAL, LLC	0.33%	162.1K	11.88M	13.41K	+9.02%
Sep 30, 2025	RICE HALL JAMES & ASSOCIATES, LLC	0.33%	164.75K	12.08M	-67.25K	-28.99%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.34%	167.23K	12.26M	124.22K	+288.82%
Sep 30, 2025	DEUTSCHE BANK AG\	0.37%	184.33K	13.51M	28.7K	+18.44%
Sep 30, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.44%	219.04K	16.06M	1.5K	+0.69%
Sep 30, 2025	TIMESSQUARE CAPITAL MANAGEMENT, LLC	0.52%	300.65K	22.04M	300.65K	+100.00%
Sep 30, 2025	PENN CAPITAL MANAGEMENT COMPANY, LLC	0.53%	307.99K	22.63M	-34.27K	-10.01%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.55%	317.15K	23.25M	317.15K	+100.00%
Sep 30, 2025	BLACKROCK, INC.	6.2%	3.6M	264.09M	25.34K	+0.71%
Sep 30, 2025	FEDERATED HERMES, INC.	0.6%	346.52K	25.4M	2.22K	+0.64%
Sep 30, 2025	WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	0.54%	313.26K	22.97M	313.26K	+100.00%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	0.78%	450.84K	33.05M	55.83K	+14.13%
Sep 30, 2025	LORD, ABBETT & CO. LLC	1.14%	661.94K	48.53M	-109.21K	-14.16%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.56%	278.76K	20.44M	31.03K	+12.53%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.88%	513.45K	37.64M	117.1K	+29.54%
Sep 30, 2025	LOOMIS SAYLES & CO L P	0.93%	539.04K	39.52M	-13.92K	-2.52%
Sep 30, 2025	WOODLINE PARTNERS LP	0.98%	567.89K	41.63M	0	0
Sep 30, 2025	FIRST TURN MANAGEMENT, LLC	0.98%	570.57K	41.83M	43.03K	+8.16%
Sep 30, 2025	EMERALD ADVISERS, LLC	0.64%	369.6K	27.1M	63.83K	+20.88%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.86%	497.47K	36.47M	254.47K	+104.72%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	1.03%	601.07K	44.06M	119.61K	+24.84%
Sep 30, 2025	FRANKLIN RESOURCES INC	1.03%	601.14K	44.07M	7.54K	+1.27%
Sep 30, 2025	NUVEEN, LLC	1.04%	601.67K	44.11M	11.41K	+1.93%
Sep 30, 2025	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	1.05%	612.32K	44.89M	536.67K	+709.47%
Sep 30, 2025	FMR LLC	1.1%	640.22K	46.93M	580.78K	+977.06%
Sep 30, 2025	MORGAN STANLEY	1.15%	670.15K	49.13M	103.82K	+18.33%
Sep 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	1.31%	761.13K	55.8M	-57.08K	-6.98%
Sep 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	1.36%	790.68K	57.96M	531.81K	+205.44%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	1.36%	790.69K	57.97M	672.12K	+566.85%
Sep 30, 2025	POLAR CAPITAL HOLDINGS PLC	1.41%	820.55K	60.15M	-154.45K	-15.84%
Sep 30, 2025	D. E. SHAW & CO., INC.	1.59%	923.51K	67.7M	368.55K	+66.41%
Sep 30, 2025	CLEARBRIDGE INVESTMENTS, LLC	1.73%	1M	73.59M	-23.72K	-2.31%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.74%	1.01M	74.06M	-19.59K	-1.90%
Sep 30, 2025	UBS GROUP AG	0.55%	275.84K	20.22M	93.39K	+51.18%
Sep 30, 2025	TWO SIGMA ADVISERS, LP	0.56%	276.4K	20.26M	105K	+61.26%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.79%	390.47K	28.63M	1.2K	+0.31%
Sep 30, 2025	MACQUARIE GROUP LTD	0.68%	393.21K	28.83M	-42.51K	-9.76%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.21%	1.28M	94.08M	-133.93K	-9.45%
Sep 30, 2025	AXA INVESTMENT MANAGERS S.A.	0.51%	255.69K	18.74M	255.69K	+100.00%
Sep 30, 2025	JANE STREET GROUP, LLC	0.51%	254.49K	18.66B	233.05K	+1,087.07%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.68%	394.49K	28.92M	11.33K	+2.96%
Sep 30, 2025	CANDRIAM S.C.A.	0.69%	403.03K	29.55M	30.02K	+8.05%
Sep 30, 2025	RAYMOND JAMES FINANCIAL INC	0.51%	251.73K	18.45M	-12.39K	-4.69%
Sep 30, 2025	ERSTE ASSET MANAGEMENT GMBH	0.5%	250K	18.21M	-10K	-3.85%
Jun 30, 2025	STATE STREET CORP	2.77%	1.38M	70.01M	-118.94K	-7.96%
Jun 30, 2025	RAYMOND JAMES FINANCIAL INC	0.53%	264.12K	13.44M	14.8K	+5.94%
Jun 30, 2025	RICE HALL JAMES & ASSOCIATES, LLC	0.47%	231.99K	11.81M	-2.7K	-1.15%
Jun 30, 2025	FMR LLC	0.12%	59.44K	3.02B	5.11K	+9.41%
Jun 30, 2025	BLACKROCK, INC.	7.19%	3.58M	182.04M	237.53K	+7.11%
Jun 30, 2025	PROSIGHT MANAGEMENT, LP	0.4%	200K	10.18M	-143.33K	-41.75%
Jun 30, 2025	ALGERT GLOBAL LLC	0.32%	159.35K	8.11M	92.59K	+138.69%
Jun 30, 2025	ESSEX INVESTMENT MANAGEMENT CO LLC	0.23%	112.73K	5.74M	112.73K	+100.00%
Jun 30, 2025	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	0.15%	75.64K	3.85M	75.64K	+100.00%
Jun 30, 2025	PALO ALTO INVESTORS LP	0.13%	64.7K	3.29M	0	0
Jun 30, 2025	SECURE ASSET MANAGEMENT, LLC	0.1%	51K	2.6M	2.09K	+4.27%
Jun 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.07%	37.21K	1.89M	-14.65K	-28.25%
Jun 30, 2025	AQUATIC CAPITAL MANAGEMENT LLC	0.07%	36.9K	1.88M	-9.41K	-20.33%
Jun 30, 2025	WOODLINE PARTNERS LP	1.14%	567.89K	28.9M	1.62K	+0.29%
Jun 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.41%	701.16K	35.68M	-77.09K	-9.91%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.77%	383.16K	19.5M	55.28K	+16.86%
Jun 30, 2025	CANDRIAM S.C.A.	0.75%	373.01K	18.98M	-9.97K	-2.60%
Jun 30, 2025	FEDERATED HERMES, INC.	0.69%	344.3K	17.52M	-3.06K	-0.88%
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.52%	258.87K	13.17M	26.77K	+11.53%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.49%	243K	12.37M	-102K	-29.57%
Jun 30, 2025	AMERIPRISE FINANCIAL INC	0.49%	242.76K	12.35M	46.88K	+23.93%
Jun 30, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	13.66%	6.8M	345.8M	0	0
Jun 30, 2025	BOONE CAPITAL MANAGEMENT LLC	1.29%	641.45K	32.64M	38.13K	+6.32%
Jun 30, 2025	MORGAN STANLEY	1.14%	566.33K	28.82M	-40.11K	-6.61%
Jun 30, 2025	PENN CAPITAL MANAGEMENT COMPANY, LLC	0.69%	342.26K	17.46M	-31.26K	-8.37%
Jun 30, 2025	NEXT CENTURY GROWTH INVESTORS LLC	0.38%	190.33K	9.69M	-5.02K	-2.57%
Jun 30, 2025	NICHOLAS INVESTMENT PARTNERS, LP	0.37%	184.48K	9.39M	11.44K	+6.61%
Jun 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.32%	159.03K	8.09M	19.59K	+14.05%
Jun 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.25%	122.77K	6.25M	-24.42K	-16.59%
Jun 30, 2025	HEALTHINVEST PARTNERS AB	0.22%	106.91K	5.44M	29.65K	+38.37%
Jun 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	5.3%	2.64M	134.22M	110.49K	+4.37%
Jun 30, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.44%	217.54K	11.07M	217.54K	+100.00%
Jun 30, 2025	JUMP FINANCIAL, LLC	0.3%	148.69K	7.57M	132.87K	+839.70%
Jun 30, 2025	NAN FUNG TRINITY (HK) LTD	0.3%	146.77K	7.47M	146.77K	+100.00%
Jun 30, 2025	PDT PARTNERS, LLC	0.29%	145.38K	7.4M	7.88K	+5.73%
Jun 30, 2025	SILVERCREST ASSET MANAGEMENT GROUP LLC	0.27%	135.92K	6.92M	0	0
Jun 30, 2025	ENSIGN PEAK ADVISORS, INC	0.27%	133.97K	6.82M	0	0
Jun 30, 2025	HIGHLANDER PARTNERS, L.P.	0.25%	122.98K	6.26M	0	0
Jun 30, 2025	PATIENT SQUARE CAPITAL LP	0.23%	113.46K	5.77M	-2.9K	-2.49%
Jun 30, 2025	TREXQUANT INVESTMENT LP	0.21%	104.3K	5.31M	104.3K	+100.00%
Jun 30, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.13%	65.76K	3.35M	-8K	-10.85%
Jun 30, 2025	BVF INC/IL	5.55%	2.76M	140.52M	-35.18K	-1.26%
Jun 30, 2025	NOVO HOLDINGS A/S	3.02%	1.5M	76.34M	55	0.00%
Jun 30, 2025	CLEARBRIDGE INVESTMENTS, LLC	2.07%	1.03M	52.29M	49.46K	+5.06%
Jun 30, 2025	POLAR CAPITAL HOLDINGS PLC	1.96%	975K	49.62M	-200K	-17.02%
Jun 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	1.65%	818.21K	41.64M	-133.56K	-14.03%
Jun 30, 2025	EMERALD ADVISERS, LLC	0.61%	305.77K	15.56M	305.77K	+100.00%
Jun 30, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.6%	298.7K	15.2M	298.7K	+100.00%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.58%	288.16K	14.66M	-191.14K	-39.88%
Jun 30, 2025	D. E. SHAW & CO., INC.	1.12%	554.96K	28.24M	11.68K	+2.15%
Jun 30, 2025	LOOMIS SAYLES & CO L P	1.11%	552.96K	28.14M	-13.2K	-2.33%
Jun 30, 2025	FIRST TURN MANAGEMENT, LLC	1.06%	527.54K	26.85M	24.53K	+4.88%
Jun 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.97%	481.46K	24.5M	-17.72K	-3.55%
Jun 30, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.85%	423.74K	21.56M	67.47K	+18.94%
Jun 30, 2025	AXA S.A.	0.71%	351.68K	17.9M	310	+0.09%
Jun 30, 2025		0.52%	260K	13.24M	0	0
Jun 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.5%	249.86K	12.72M	-10.51K	-4.04%
Jun 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.5%	247.73K	12.61M	18.28K	+7.97%
Jun 30, 2025	EVERSEPT PARTNERS, LP	0.47%	232.18K	11.82M	232.18K	+100.00%
Jun 30, 2025	JANUS HENDERSON GROUP PLC	10.53%	5.24M	266.48M	470.17K	+9.86%
Jun 30, 2025	VANGUARD GROUP INC	5.16%	2.56M	130.53M	24.81K	+0.98%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.85%	1.42M	72.12M	2.08K	+0.15%
Jun 30, 2025	CITADEL ADVISORS LLC	2.83%	1.41M	71.57M	-39.64K	-2.74%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.07%	1.03M	52.4M	65.95K	+6.84%
Jun 30, 2025	LORD, ABBETT & CO. LLC	1.55%	771.15K	39.24M	-42.25K	-5.19%
Jun 30, 2025	FRANKLIN RESOURCES INC	1.19%	593.6K	30.21M	241	+0.04%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	1%	496.06K	25.24M	249.33K	+101.05%
Jun 30, 2025	JPMORGAN CHASE & CO	0.97%	480.28K	24.44M	192.34K	+66.80%
Jun 30, 2025	MACQUARIE GROUP LTD	0.88%	435.72K	22.17M	68.97K	+18.80%
Jun 30, 2025	NORTHERN TRUST CORP	0.81%	402.4K	20.48M	13.48K	+3.46%
Jun 30, 2025	NUVEEN, LLC	1.19%	590.26K	30.04M	-64.47K	-9.85%
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.8%	396.35K	20.17M	207.85K	+110.26%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.79%	395.01K	20.1M	-82.64K	-17.30%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.78%	389.27K	19.81M	10.65K	+2.81%
Jun 30, 2025	ERSTE ASSET MANAGEMENT GMBH	0.52%	260K	13.24M	0	0
Jun 30, 2025	TANG CAPITAL MANAGEMENT LLC	2.49%	1.24M	62.9M	-1.08K	-0.09%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.77%	378.62K	17.06M	-64.01K	-14.46%
Mar 31, 2025	CANDRIAM S.C.A.	0.78%	382.98K	17.25M	-46.75K	-10.88%
Mar 31, 2025	NORTHERN TRUST CORP	0.8%	388.92K	17.52M	-10.62K	-2.66%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.98%	477.65K	21.52M	-77.99K	-14.04%
Mar 31, 2025	FIRST TURN MANAGEMENT, LLC	1.03%	503.01K	22.66M	-3.89K	-0.77%
Mar 31, 2025	LOOMIS SAYLES & CO L P	1.16%	566.16K	25.51M	-11.87K	-2.05%
Mar 31, 2025	FRANKLIN RESOURCES INC	1.21%	593.36K	26.73M	2.69K	+0.46%
Mar 31, 2025	MORGAN STANLEY	1.24%	606.43K	27.32M	-151.95K	-20.04%
Mar 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.59%	778.24K	35.06M	-81.85K	-9.52%
Mar 31, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.53%	260.37K	11.73M	32.02K	+14.02%
Mar 31, 2025	D. E. SHAW & CO., INC.	1.11%	543.28K	24.47M	385.93K	+245.26%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.98%	479.3K	21.59M	-47.68K	-9.05%
Mar 31, 2025	TANG CAPITAL MANAGEMENT LLC	2.53%	1.24M	55.73M	0	0
Mar 31, 2025	PENN CAPITAL MANAGEMENT COMPANY, LLC	0.76%	373.52K	16.87M	95.09K	+34.15%
Mar 31, 2025	CLEARBRIDGE INVESTMENTS, LLC	2%	978.07K	44.06M	70.75K	+7.80%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.89%	1.42M	63.75M	-7.59K	-0.53%
Mar 31, 2025	CITADEL ADVISORS LLC	2.96%	1.45M	65.14M	-65.19K	-4.31%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.5%	246.73K	11.12M	122.4K	+98.45%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.67%	327.88K	14.77M	-4.76K	-1.43%
Mar 31, 2025	STATE STREET CORP	3.06%	1.49M	67.33M	112.94K	+8.17%
Mar 31, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.47%	229.45K	10.34M	203.49K	+783.86%
Mar 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.47%	232.1K	10.46M	232.1K	+100.00%
Mar 31, 2025	RICE HALL JAMES & ASSOCIATES, LLC	0.48%	234.7K	10.57M	-4.3K	-1.80%
Mar 31, 2025	INVESCO LTD.	0.64%	313.42K	14.12M	14.14K	+4.73%
Mar 31, 2025	UBS GROUP AG	0.48%	235.96K	10.63M	51.37K	+27.83%
Mar 31, 2025	MACQUARIE GROUP LTD	0.75%	366.75K	16.52M	366.75K	+100.00%
Mar 31, 2025	WOODLINE PARTNERS LP	1.16%	566.27K	25.51M	161.87K	+40.03%
Mar 31, 2025	BOONE CAPITAL MANAGEMENT LLC	1.23%	603.32K	27.18M	21.48K	+3.69%
Mar 31, 2025	JANUS HENDERSON GROUP PLC	9.75%	4.77M	219.25M	184.47K	+4.03%
Mar 31, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	13.9%	6.8M	306.12M	224.73K	+3.42%
Mar 31, 2025		0.53%	260K	11.74M	0	0
Mar 31, 2025	PROSIGHT MANAGEMENT, LP	0.7%	343.33K	15.47M	-107.8K	-23.90%
Mar 31, 2025	RAYMOND JAMES FINANCIAL INC	0.51%	249.32K	11.23M	-7.29K	-2.84%
Mar 31, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.73%	356.28K	16.05M	179.32K	+101.33%
Mar 31, 2025	DEUTSCHE BANK AG\	0.49%	240.74K	10.85M	71.42K	+42.18%
Mar 31, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0.61%	296.89K	13.37M	212.92K	+253.57%
Mar 31, 2025	JPMORGAN CHASE & CO	0.59%	287.94K	12.97M	-97.21K	-25.24%
Mar 31, 2025	LORD, ABBETT & CO. LLC	1.66%	813.4K	36.64M	31.04K	+3.97%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.97%	963.67K	43.42M	20.32K	+2.15%
Mar 31, 2025	POLAR CAPITAL HOLDINGS PLC	2.4%	1.18M	52.93M	500K	+74.07%
Mar 31, 2025	BNP PARIBAS ARBITRAGE, SNC	1.02%	499.18K	22.49M	237.54K	+90.79%
Mar 31, 2025	BVF INC/IL	5.72%	2.8M	125.98M	0	0
Mar 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.71%	345K	15.54M	195K	+130.00%
Mar 31, 2025	FEDERATED HERMES, INC.	0.71%	347.37K	15.65M	343.73K	+9,440.40%
Mar 31, 2025	VANGUARD GROUP INC	5.2%	2.54M	114.43M	115.33K	+4.76%
Mar 31, 2025	AXA S.A.	0.72%	351.37K	15.83M	-74.27K	-17.45%
Mar 31, 2025	BLACKROCK, INC.	6.83%	3.34M	150.45M	-95.07K	-2.77%
Mar 31, 2025	EVENTIDE ASSET MANAGEMENT, LLC	5.17%	2.53M	113.85M	-79.94K	-3.07%
Mar 31, 2025	NOVO HOLDINGS A/S	3.07%	1.5M	67.58M	0	0
Mar 31, 2024	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.16%	64.42K	1.62M	31.24K	+94.14%
Mar 31, 2024	SCHRODER INVESTMENT MANAGEMENT GROUP	0.17%	67.5K	1.7M	0	0
Mar 31, 2024	PROPEL BIO MANAGEMENT, LLC	0.17%	70K	1.76M	0	0
Mar 31, 2024	SIMPLIFY ASSET MANAGEMENT INC.	0.17%	70K	1.76M	0	0
Mar 31, 2024	SILVERARC CAPITAL MANAGEMENT, LLC	0.19%	79.19K	1.99M	-1.62K	-2.00%
Mar 31, 2024	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.23%	92.25K	2.32M	92.25K	+100.00%
Mar 31, 2024	ALPHACENTRIC ADVISORS LLC	0.23%	94K	2.36M	44K	+88.00%
Mar 31, 2024	NAN FUNG GROUP HOLDINGS LTD	0.23%	96.1K	2.41M	0	0
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.24%	96.49K	2.42M	-20.79K	-17.73%
Mar 31, 2024	RAYMOND JAMES FINANCIAL SERVICES ADVISORS, INC.	0.24%	97.89K	2.46M	37.84K	+63.02%
Mar 31, 2024	KNIGHTS OF COLUMBUS ASSET ADVISORS LLC	0.25%	102.28K	2.57M	-14.37K	-12.32%
Mar 31, 2024	ABRDN PLC	0.27%	109.76K	2.76M	109.76K	+100.00%
Mar 31, 2024	CENTERBOOK PARTNERS LP	0.3%	122.46K	3.08M	70.62K	+136.23%
Mar 31, 2024	HIGHLANDER PARTNERS, L.P.	0.3%	122.98K	3.09M	0	0
Mar 31, 2024	HEALTHINVEST PARTNERS AB	0.3%	123K	3.09M	123K	+100.00%
Mar 31, 2024	RAYMOND JAMES & ASSOCIATES	0.32%	130.56K	3.28M	-5.12K	-3.77%
Mar 31, 2024	JPMORGAN CHASE & CO	0.36%	145.56K	3.66M	-41.02K	-21.99%
Mar 31, 2024	NICHOLAS INVESTMENT PARTNERS, LP	0.37%	151K	3.79M	-247.88K	-62.14%
Mar 31, 2024	UBS GROUP AG	0.38%	156.91K	3.94M	38.37K	+32.37%
Mar 31, 2024	AVIDITY PARTNERS MANAGEMENT LP	2.8%	1.14M	28.71M	0	0
Mar 31, 2024	VANGUARD GROUP INC	5.41%	2.21M	55.56M	-264.56K	-10.68%
Mar 31, 2024	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	15.89%	6.5M	163.16M	0	0
Mar 31, 2024	AFFINITY ASSET ADVISORS, LLC	0.39%	160K	4.02M	110K	+220.00%
Mar 31, 2024	ENSIGN PEAK ADVISORS, INC	0.54%	222.61K	5.59M	0	0
Mar 31, 2024	WOODLINE PARTNERS LP	0.57%	233.27K	5.86M	-20K	-7.90%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.59%	241.5K	6.07M	116.86K	+93.75%
Mar 31, 2024	DEUTSCHE BANK AG\	0.6%	244.15K	6.13M	72.63K	+42.34%
Mar 31, 2024	ARDSLEY ADVISORY PARTNERS LP	0.6%	245K	6.15M	20K	+8.89%
Mar 31, 2024	ELEQUIN SECURITIES, LLC	0.6%	245.7K	6.18M	245.6K	+264,089.25%
Mar 31, 2024	PENN CAPITAL MANAGEMENT COMPANY, LLC	0.6%	245.7K	6.18M	-32	-0.01%
Mar 31, 2024	CLEARBRIDGE INVESTMENTS, LLC	0.64%	263.58K	6.62M	-513	-0.19%
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	0.65%	266.26K	6.69M	135.92K	+104.27%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.66%	271.65K	6.82M	4.97K	+1.86%
Mar 31, 2024	BARCLAYS PLC	0.67%	274.87K	6.9M	174.94K	+175.08%
Mar 31, 2024	NORTHERN TRUST CORP	0.69%	281.08K	7.06M	-6.96K	-2.42%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.76%	311.19K	7.82M	-159.16K	-33.84%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.76%	312.61K	7.85M	161.79K	+107.27%
Mar 31, 2024	CITIGROUP INC	0.91%	371.05K	9.32M	285.82K	+335.35%
Mar 31, 2024	BOONE CAPITAL MANAGEMENT LLC	1.11%	451.9K	11.35M	-38.24K	-7.80%
Mar 31, 2024	PROSIGHT MANAGEMENT, LP	1.14%	465K	11.68M	171.7K	+58.54%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	1.32%	539.67K	13.56M	315.29K	+140.52%
Mar 31, 2024	AXA S.A.	1.45%	593.79K	14.92M	73	+0.01%
Mar 31, 2024	POLAR CAPITAL HOLDINGS PLC	1.53%	625K	15.7M	0	0
Mar 31, 2024	WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	1.53%	627.27K	15.76M	5.49K	+0.88%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	1.71%	697.14K	17.52M	15.96K	+2.34%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	1.71%	700.12K	17.59M	243.8K	+53.43%
Mar 31, 2024	FRANKLIN RESOURCES INC	2.3%	941.37K	23.65M	28.31K	+3.10%
Mar 31, 2024	PICTET ASSET MANAGEMENT HOLDING SA	2.34%	955.91K	24.01M	162.26K	+20.44%
Mar 31, 2024	FIRST TURN MANAGEMENT, LLC	2.34%	958.65K	24.08M	122.35K	+14.63%
Mar 31, 2024	CADIAN CAPITAL MANAGEMENT, LP	5.61%	2.29M	57.59M	357.65K	+18.48%
Mar 31, 2024	BLACKROCK INC.	6%	2.45M	61.6M	-9.48K	-0.39%
Mar 31, 2024	JANUS HENDERSON GROUP PLC	6.77%	2.77M	69.47M	704.66K	+34.16%
Mar 31, 2024	RICE HALL JAMES & ASSOCIATES, LLC	0.53%	214.89K	5.4M	172.05K	+401.60%
Mar 31, 2024	MORGAN STANLEY	0.87%	354.59K	8.91M	109.9K	+44.91%
Mar 31, 2024	CHECKPOINT CAPITAL L.P.	0.89%	362.19K	9.1M	128.53K	+55.01%
Mar 31, 2024	STATE STREET CORP	6.9%	2.82M	70.9M	1.09M	+62.70%
Mar 31, 2024	EVENTIDE ASSET MANAGEMENT, LLC	8.07%	3.3M	82.91M	636.75K	+23.91%
Mar 31, 2024	BVF INC/IL	10.69%	4.37M	109.78M	0	0
Mar 31, 2024	INVESCO LTD.	0.1%	39.02K	980.21K	-45.85K	-54.02%
Mar 31, 2024	PROFUND ADVISORS LLC	0.1%	40.86K	1.03B	19.69K	+93.03%
Mar 31, 2024	LOS ANGELES CAPITAL MANAGEMENT LLC	0.1%	41.84K	1.05M	4.07K	+10.77%
Mar 31, 2024	SECURE ASSET MANAGEMENT, LLC	0.1%	42.27K	1.06M	3.07K	+7.83%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.11%	44.19K	1.11M	5.67K	+14.71%
Mar 31, 2024	BANK OF MONTREAL /CAN/	0.11%	45.27K	1.32M	-4.52K	-9.08%
Mar 31, 2024	STATE OF WISCONSIN INVESTMENT BOARD	0.11%	45.82K	1.15M	17.09K	+59.49%
Mar 31, 2024	SWISS NATIONAL BANK	0.15%	59.3K	1.49M	0	0
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.15%	59.8K	1.5B	12.8K	+27.23%
Mar 31, 2024	PHOCAS FINANCIAL CORP.	0.15%	61.54K	1.55M	61.54K	+100.00%
Mar 31, 2024	HENNION & WALSH ASSET MANAGEMENT, INC.	0.16%	63.53K	1.6M	15.02K	+30.97%
Mar 31, 2024	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.39%	160K	4.02M	-415K	-72.17%
Mar 31, 2024	SILVERCREST ASSET MANAGEMENT GROUP LLC	0.4%	162.82K	4.09M	63.87K	+64.55%
Mar 31, 2024	BAKER BROS. ADVISORS LP	0.47%	190.48K	4.78M	0	0
Mar 31, 2024	NEW YORK STATE COMMON RETIREMENT FUND	0.48%	196.68K	4.94M	-26.19K	-11.75%
Mar 31, 2024	TWO SIGMA ADVISERS, LP	0.48%	197K	4.95M	-139.3K	-41.42%
Mar 31, 2024	ALTIUM CAPITAL MANAGEMENT LP	0.51%	208K	5.22M	208K	+100.00%
Mar 31, 2024	TANG CAPITAL MANAGEMENT LLC	2.9%	1.19M	29.82M	50K	+4.40%
Mar 31, 2024	CITADEL ADVISORS LLC	3.41%	1.39M	34.98M	-50.31K	-3.49%
Mar 31, 2024	NOVO HOLDINGS A/S	3.67%	1.5M	37.68M	0	0
Mar 31, 2024	PRICE T ROWE ASSOCIATES INC /MD/	3.91%	1.6M	40.13M	432.82K	+37.16%
Mar 31, 2024	ROCK SPRINGS CAPITAL MANAGEMENT LP	4.54%	1.86M	46.64M	5.1K	+0.28%
Dec 31, 2023	TWO SIGMA ADVISERS, LP	0.82%	336.3K	9.93M	-54.6K	-13.97%
Dec 31, 2023	PROSIGHT MANAGEMENT, LP	0.71%	293.3K	8.66M	-60.21K	-17.03%
Dec 31, 2023	NORTHERN TRUST CORP	0.7%	288.04K	8.5M	12.8K	+4.65%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.65%	266.68K	7.87M	42.11K	+18.75%
Dec 31, 2023	CLEARBRIDGE INVESTMENTS, LLC	0.64%	264.1K	7.8M	247.93K	+1,533.86%
Dec 31, 2023	WOODLINE PARTNERS LP	0.62%	253.26K	7.48M	-199.44K	-44.06%
Dec 31, 2023	PENN CAPITAL MANAGEMENT COMPANY, LLC	0.6%	245.73K	7.26M	-242	-0.10%
Dec 31, 2023	MORGAN STANLEY	0.6%	244.69K	7.22M	97.78K	+66.55%
Dec 31, 2023		0.57%	233.66K	6.9M	233.66K	+100.00%
Dec 31, 2023	ARDSLEY ADVISORY PARTNERS LP	0.55%	225K	6.64M	125K	+125.00%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	0.55%	224.38K	6.62M	87.97K	+64.49%
Dec 31, 2023	NEW YORK STATE COMMON RETIREMENT FUND	0.54%	222.86K	6.58M	918	+0.41%
Dec 31, 2023	ENSIGN PEAK ADVISORS, INC	0.54%	222.61K	6.57M	0	0
Dec 31, 2023	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	0.52%	211.95K	6.26M	111.95K	+111.95%
Dec 31, 2023	BLACKROCK INC.	5.99%	2.46M	72.67M	348.34K	+16.48%
Dec 31, 2023	VANGUARD GROUP INC	6.03%	2.48M	73.1M	782.9K	+46.23%
Dec 31, 2023	EVENTIDE ASSET MANAGEMENT, LLC	6.48%	2.66M	78.63M	-1.29M	-32.71%
Dec 31, 2023	BVF INC/IL	10.63%	4.37M	129M	0	0
Dec 31, 2023	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	15.8%	6.5M	191.74M	25K	+0.39%
Dec 31, 2023	TEACHER RETIREMENT SYSTEM OF TEXAS	0.33%	137.22K	4.05M	130.21K	+1,858.55%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.37%	150.82K	4.45M	28.18K	+22.97%
Dec 31, 2023	DEUTSCHE BANK AG\	0.42%	171.53K	5.06M	157.16K	+1,094.14%
Dec 31, 2023	JPMORGAN CHASE & CO	0.45%	186.58K	5.51M	86.81K	+87.00%
Dec 31, 2023	PATHWAY CAPITAL MANAGEMENT, LP	0.46%	190.29K	5.62M	190.29K	+100.00%
Dec 31, 2023	BAKER BROS. ADVISORS LP	0.46%	190.48K	5.62M	0	0
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	0.48%	196.13K	5.79M	-132.66K	-40.35%
Dec 31, 2023	FRANKLIN RESOURCES INC	2.22%	913.07K	26.95M	168.45K	+22.62%
Dec 31, 2023	TANG CAPITAL MANAGEMENT LLC	2.77%	1.14M	33.57M	0	0
Dec 31, 2023	AVIDITY PARTNERS MANAGEMENT LP	2.78%	1.14M	33.74M	0	0
Dec 31, 2023	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0.51%	211.11K	6.23M	183.8K	+672.93%
Dec 31, 2023	PRICE T ROWE ASSOCIATES INC /MD/	2.83%	1.16M	34.38M	1.13M	+3,544.30%
Dec 31, 2023	CITADEL ADVISORS LLC	3.51%	1.44M	42.59M	-274.45K	-15.98%
Dec 31, 2023	NOVO HOLDINGS A/S	3.65%	1.5M	44.28M	0	0
Dec 31, 2023	STATE STREET CORP	4.22%	1.73M	51.21M	113.87K	+7.02%
Dec 31, 2023	ROCK SPRINGS CAPITAL MANAGEMENT LP	4.5%	1.85M	54.66M	30.73K	+1.69%
Dec 31, 2023	CADIAN CAPITAL MANAGEMENT, LP	4.71%	1.93M	57.12M	500K	+34.85%
Dec 31, 2023	JANUS HENDERSON GROUP PLC	5.02%	2.06M	60.89M	138.79K	+7.21%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.66%	681.18K	20.11M	106.1K	+18.45%
Dec 31, 2023	POLAR CAPITAL HOLDINGS PLC	1.52%	625K	18.45M	-550K	-46.81%
Dec 31, 2023	WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	1.51%	621.78K	18.35M	88.09K	+16.50%
Dec 31, 2023	AXA S.A.	1.44%	593.71K	17.53M	-23.4K	-3.79%
Dec 31, 2023	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.4%	575K	16.97M	-90K	-13.53%
Dec 31, 2023	PERCEPTIVE ADVISORS LLC	1.3%	534.94K	15.79M	-137.1K	-20.40%
Dec 31, 2023	BOONE CAPITAL MANAGEMENT LLC	1.19%	490.14K	14.47M	100.35K	+25.74%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	1.14%	470.34K	13.88M	37.56K	+8.68%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	1.11%	456.32K	13.47M	215.54K	+89.52%
Dec 31, 2023	NICHOLAS INVESTMENT PARTNERS, LP	0.97%	398.88K	11.78M	-800.48K	-66.74%
Dec 31, 2023	SOFINNOVA INVESTMENTS, INC.	0.86%	352.4K	10.4M	343.31K	+3,777.18%

Insiders

Among the MIRM insiders holding of 1.86% of the stake in company, NEW ENTERPRISE ASSOCIATES 16, L.P., 10 percent owner, holds the largest shares of 4.19M. WALKER PAUL EDWARD, 10 percent owner, is the second largest MIRM insider with ownership of 4.19M shares. SONSINI PETER W., 10 percent owner, stands third with possession of 4.19M shares of that stake.

Insiders	Designation	Shares Held
NEW ENTERPRISE ASSOCIATES 16, L.P.	10 percent owner	4.19M
WALKER PAUL EDWARD	10 percent owner	4.19M
SONSINI PETER W.	10 percent owner	4.19M
SANDELL SCOTT D	10 percent owner	4.19M
MOTT DAVID M	10 percent owner	4.19M
MAKOWER JOSHUA	10 percent owner	4.19M
MAKHZOUMI MOHAMAD	10 percent owner	4.19M
FLORENCE ANTHONY A. JR.	10 percent owner	4.19M
CHANG CARMEN	10 percent owner	4.19M
BASKETT FOREST	10 percent owner	4.19M
BARRIS PETER J	10 percent owner	4.19M
BEHBAHANI ALI	10 percent owner	4.19M
FRAZIER LIFE SCIENCES IX, L.P.	10 percent owner	3.57M
NOVO HOLDINGS A/S	10 percent owner	2.45M
O'DONNELL NIALL	director	1.62M
DEERFIELD HEALTHCARE INNOVATIONS FUND, L.P.		1.54M
FLYNN JAMES E	* Possible Member of 10% Group	1.54M
HERON PATRICK J	director	459.01K
PEETZ CHRISTOPHER	CHIEF EXECUTIVE OFFICER	160.29K
LONGPRE LARA	CHIEF DEVELOPMENT OFFICER	104.41K
TUCKER EDWIN JONATHAN	Chief Medical Officer	45.77K
BJERKHOLT ERIC	CHIEF FINANCIAL OFFICER	43.74K
VIG PAMELA	CHIEF SCIENTIFIC OFFICER	27.41K
RADOVICH PETER	PRESIDENT AND COO	20.66K
CLEMENTS IAN	Chief Financial Officer	18.56K
BREGE LAURA	director	15.7K
QUAN JOANNE	CHIEF MEDICAL OFFICER	12.82K
FISCHER LAURENT	director	6.75K
HOWE JOLANDA	SVP, GLOBAL CONTROLLER	4.5K
FAIREY WILLIAM	director	2.5K
GREY MICHAEL G	director	0
RAMASASTRY SAIRA	director	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Feb 13, 2026	RAMASASTRY SAIRA	SALE	102.09	2K	204.18K	0
Feb 02, 2026	HOWE JOLANDA	SALE	103.30	968	100K	4.5K
Feb 02, 2026	PEETZ CHRISTOPHER	SALE	103.30	9.11K	940.89K	160.29K
Feb 02, 2026	RADOVICH PETER	SALE	103.30	2.63K	271.79K	20.66K
Jan 26, 2026	HOWE JOLANDA	SALE	96.19	842	80.99K	3.7K
Jan 26, 2026	RADOVICH PETER	SALE	96.19	3.14K	302.33K	23.29K
Jan 26, 2026	BJERKHOLT ERIC	SALE	96.19	1.05K	101.29K	43.74K
Jan 26, 2026	PEETZ CHRISTOPHER	SALE	96.19	6.83K	657.09K	169.4K
Jan 23, 2026	HERON PATRICK J	PURCHASE	68.48	131.43K	9M	459.01K
Jan 22, 2026	BJERKHOLT ERIC	SALE	93.33	1.42K	132.62K	42.13K
Jan 22, 2026	PEETZ CHRISTOPHER	SALE	93.33	7.1K	662.42K	163.73K
Jan 22, 2026	RADOVICH PETER	SALE	93.33	2.38K	222.3K	20.68K
Jan 22, 2026	HOWE JOLANDA	SALE	93.33	926	86.42K	3.04K
Jan 22, 2026	QUAN JOANNE	SALE	93.33	1.82K	170.04K	12.82K
Jan 20, 2026	QUAN JOANNE	SALE	90.27	6.91K	623.85K	11.31K
Jan 15, 2026	RAMASASTRY SAIRA	SALE	90.99	2K	181.98K	0
Dec 22, 2025	RAMASASTRY SAIRA	SALE	80.00	5K	400K	0
Dec 19, 2025	GREY MICHAEL G	SALE	78.00	50K	3.9M	0
Dec 18, 2025	RAMASASTRY SAIRA	SALE	70.00	1K	70K	0
Dec 01, 2025	GREY MICHAEL G	SALE	74.00	50K	3.7M	0
Nov 21, 2025	GREY MICHAEL G	SALE	70.00	50K	3.5M	0
Sep 12, 2025	BJERKHOLT ERIC	SALE	76.01	9.58K	728.02K	39.95K
Sep 11, 2025	BREGE LAURA	SALE	75.07	1.49K	111.93K	15.7K
Sep 08, 2025	RAMASASTRY SAIRA	SALE	0.00	17K	-	0
Aug 11, 2025	BJERKHOLT ERIC	SALE	0.00	8K	-	28.24K
Aug 11, 2025	PEETZ CHRISTOPHER	SALE	62.00	40K	2.48M	138.64K
Aug 07, 2025	PEETZ CHRISTOPHER	SALE	55.25	40K	2.21M	138.64K
Aug 07, 2025	HOWE JOLANDA	SALE	58.00	10K	580K	2.43K
Jul 03, 2025	HOWE JOLANDA	SALE	49.08	477	23.41K	2.43K
Jul 02, 2025	HOWE JOLANDA	SALE	48.25	564	27.21K	2.9K
Jun 11, 2025	FAIREY WILLIAM	SALE	48.42	3.2K	155.09K	2.5K
Jun 03, 2025	RAMASASTRY SAIRA	SALE	45.74	2.5K	114.35K	0
Jun 02, 2025	RAMASASTRY SAIRA	SALE	46.20	5.7K	263.49K	0
Mar 18, 2025	HOWE JOLANDA	SALE	44.45	2.42K	107.34K	2.43K
Mar 17, 2025	HERON PATRICK J	PURCHASE	43.93	21	922.61	168.67K
Mar 17, 2025	HOWE JOLANDA	SALE	44.36	1.81K	80.11K	4.84K
Mar 17, 2025	RADOVICH PETER	SALE	44.21	7.88K	348.36K	18.67K
Mar 17, 2025	PEETZ CHRISTOPHER	SALE	44.21	27.28K	1.21M	138.64K
Mar 14, 2025	HERON PATRICK J	PURCHASE	44.11	528	23.29K	168.65K
Mar 11, 2025	HERON PATRICK J	PURCHASE	43.77	963	42.16K	168.12K
Mar 10, 2025	HERON PATRICK J	PURCHASE	42.66	758	32.34K	166.58K
Mar 07, 2025	HERON PATRICK J	PURCHASE	43.21	580	25.06K	165.83K
Mar 06, 2025	HERON PATRICK J	PURCHASE	43.89	1.34K	58.6K	165.25K
Mar 05, 2025	HERON PATRICK J	PURCHASE	44.55	267	11.89K	163.91K
Mar 04, 2025	HERON PATRICK J	PURCHASE	45.55	1.28K	58.26K	163.59K
Mar 04, 2025	RADOVICH PETER	SALE	45.74	1.17K	53.47K	12.11K
Mar 03, 2025	PEETZ CHRISTOPHER	SALE	47.19	20.61K	972.49K	115.92K
Feb 03, 2025	HOWE JOLANDA	SALE	48.22	1.06K	51.31K	4.23K
Feb 03, 2025	RADOVICH PETER	SALE	48.22	2.63K	126.68K	26.96K
Feb 03, 2025	PEETZ CHRISTOPHER	SALE	48.22	9.1K	438.92K	115.92K
Jan 24, 2025	RADOVICH PETER	SALE	47.92	3.18K	152.26K	29.59K
Jan 24, 2025	PEETZ CHRISTOPHER	SALE	47.92	6.84K	327.66K	125.02K
Jan 24, 2025	HOWE JOLANDA	SALE	47.92	902	43.23K	3.52K
Jan 17, 2025	QUAN JOANNE	SALE	45.86	6.97K	319.6K	5.65K
Jan 07, 2025	RADOVICH PETER	SALE	42.82	2K	85.54K	27.02K
Jan 07, 2025	PEETZ CHRISTOPHER	SALE	42.82	7.49K	320.64K	119.36K
Jan 07, 2025	HOWE JOLANDA	SALE	42.82	750	32.11K	2.93K
Nov 14, 2024	HOWE JOLANDA	SALE	47.10	2.5K	117.75K	2.43K
Sep 18, 2024	HERON PATRICK J	PURCHASE	37.40	115	4.3K	162.31K
Sep 06, 2024	HERON PATRICK J	PURCHASE	41.58	230	9.56K	162.19K
Jul 02, 2024	HOWE JOLANDA	SALE	34.00	375	12.75K	2.43K
Jun 24, 2024	VIG PAMELA	SALE	34.00	30.56K	1.04M	27.41K
Jun 05, 2024	RAMASASTRY SAIRA	SALE	25.68	5K	128.4K	0
Mar 27, 2024	BJERKHOLT ERIC	PURCHASE	24.80	2K	49.6K	14K
Mar 25, 2024	RADOVICH PETER	SALE	25.80	4.3K	111.02K	29.01K
Mar 18, 2024	BJERKHOLT ERIC	PURCHASE	25.80	2K	51.6K	12K
Feb 02, 2024	RADOVICH PETER	SALE	26.19	1.79K	46.88K	34.7K
Feb 02, 2024	PEETZ CHRISTOPHER	SALE	26.19	6.01K	157.49K	104.11K
Feb 02, 2024	VIG PAMELA	SALE	26.19	1.21K	31.8K	28.69K
Feb 02, 2024	HOWE JOLANDA	SALE	26.19	735	19.25K	1.76K
Feb 02, 2024	LONGPRE LARA	SALE	26.19	847	22.18K	104.41K
Jan 08, 2024	HOWE JOLANDA	SALE	28.04	528	14.8K	722
Jan 08, 2024	PEETZ CHRISTOPHER	SALE	28.03	5.21K	146.03K	110.13K
Jan 08, 2024	VIG PAMELA	SALE	28.03	1.41K	39.47K	29.91K
Jan 08, 2024	RADOVICH PETER	SALE	28.03	1.41K	39.47K	36.49K
Jan 08, 2024	LONGPRE LARA	SALE	28.04	1.02K	28.57K	105.25K
Dec 05, 2023	HOWE JOLANDA	SALE	32.40	2.5K	81K	0
Nov 09, 2023	HERON PATRICK J	PURCHASE	28.30	2.91K	82.35K	161.96K
Sep 14, 2023	GREY MICHAEL G	SALE	32.00	14.22K	454.91K	0
Sep 13, 2023	HERON PATRICK J	PURCHASE	31.02	2.63K	81.42K	159.05K
Sep 12, 2023	HERON PATRICK J	PURCHASE	30.60	3.75K	114.76K	156.43K
Sep 11, 2023	BJERKHOLT ERIC	PURCHASE	29.65	10K	296.49K	10K
Sep 11, 2023	HERON PATRICK J	PURCHASE	30.30	4.69K	142.03K	152.68K
Aug 31, 2023	HERON PATRICK J	PURCHASE	26.25	147.99K	3.88M	147.99K
Aug 25, 2023	HOWE JOLANDA	SALE	26.23	3.46K	90.74K	0
Jul 03, 2023	HOWE JOLANDA	SALE	25.65	915	23.47K	3.46K
Jul 03, 2023	PEETZ CHRISTOPHER	SALE	25.65	5.5K	141.01K	115.33K
Jul 03, 2023	LONGPRE LARA	SALE	25.65	1K	25.75K	105.84K
Jul 03, 2023	RADOVICH PETER	SALE	25.65	1.43K	36.55K	37.68K
Jul 03, 2023	VIG PAMELA	SALE	25.65	1.43K	36.55K	30.79K
Jun 08, 2023	GREY MICHAEL G	SALE	29.00	14.61K	423.63K	0
May 03, 2023	GREY MICHAEL G	SALE	28.00	14.61K	409.02K	0
Jan 09, 2023	PEETZ CHRISTOPHER	SALE	20.62	5.16K	106.39K	91.95K
Jan 09, 2023	LONGPRE LARA	SALE	20.62	1K	20.68K	104.37K
Jan 09, 2023	RADOVICH PETER	SALE	20.62	1.38K	28.44K	33.32K
Jan 09, 2023	VIG PAMELA	SALE	20.62	1.38K	28.44K	27.31K
Nov 15, 2022	O'DONNELL NIALL	SALE	19.69	93.77K	1.85M	1.62M
Nov 14, 2022	O'DONNELL NIALL	SALE	19.60	32.11K	629.42K	1.71M
Nov 11, 2022	O'DONNELL NIALL	SALE	19.99	174.12K	3.48M	1.75M
Jun 06, 2022	FLYNN JAMES E	SALE	24.47	6.24K	152.77K	1.54M
Jun 06, 2022	DEERFIELD HEALTHCARE INNOVATIONS FUND, L.P.	SALE	24.47	6.24K	152.77K	1.54M
Nov 26, 2021	CLEMENTS IAN	PURCHASE	13.90	750	10.43K	18.56K
Nov 24, 2021	CLEMENTS IAN	PURCHASE	14.40	700	10.08K	17.81K
Nov 24, 2021	PEETZ CHRISTOPHER	PURCHASE	14.40	7K	100.8K	28.03K
Oct 01, 2021	RADOVICH PETER	SALE	19.26	1.36K	26.26K	11.27K
Oct 01, 2021	TUCKER EDWIN JONATHAN	SALE	19.26	1.36K	26.26K	45.77K
Oct 01, 2021	LONGPRE LARA	SALE	19.26	961	18.51K	84.25K
Oct 01, 2021	CLEMENTS IAN	SALE	19.26	1.57K	30.31K	16.65K
Oct 01, 2021	PEETZ CHRISTOPHER	SALE	19.26	3.67K	70.71K	21.03K
Oct 01, 2021	VIG PAMELA	SALE	19.26	1.36K	26.26K	9.67K
Jul 09, 2021	FLYNN JAMES E	SALE	15.81	99.33K	1.57M	0
Jul 07, 2021	FLYNN JAMES E	SALE	15.87	6.84K	108.5K	99.33K
Jul 06, 2021	FLYNN JAMES E	SALE	16.20	49.24K	797.43K	106.16K
Jul 02, 2021	FLYNN JAMES E	SALE	17.01	10.6K	180.3K	155.4K
Dec 23, 2020	PEETZ CHRISTOPHER	PURCHASE	18.76	3K	56.28K	199.57K
Dec 23, 2020	CLEMENTS IAN	PURCHASE	18.55	908	16.84K	6.28K
Mar 20, 2020	TUCKER EDWIN JONATHAN	PURCHASE	11.90	2.5K	29.74K	6K
Mar 19, 2020	TUCKER EDWIN JONATHAN	PURCHASE	9.91	2K	19.82K	3.5K
Sep 17, 2019	FISCHER LAURENT	PURCHASE	9.37	1.65K	15.44K	6.75K
Sep 16, 2019	FISCHER LAURENT	PURCHASE	9.47	452	4.28K	5.1K
Sep 10, 2019	LONGPRE LARA	PURCHASE	10.64	965	10.27K	105.37K
Sep 10, 2019	FISCHER LAURENT	PURCHASE	10.29	960	9.88K	4.65K
Sep 10, 2019	BREGE LAURA	PURCHASE	11.22	10K	112.2K	10K
Sep 09, 2019	FISCHER LAURENT	PURCHASE	10.54	1.67K	17.6K	3.39K
Sep 09, 2019	PEETZ CHRISTOPHER	PURCHASE	10.90	2K	21.8K	194.25K
Sep 06, 2019	FISCHER LAURENT	PURCHASE	10.71	1.72K	18.43K	1.72K
Sep 06, 2019	PEETZ CHRISTOPHER	PURCHASE	10.91	4.75K	51.81K	192.25K
Sep 06, 2019	VIG PAMELA	PURCHASE	10.96	1.6K	17.54K	1.6K
Sep 06, 2019	CLEMENTS IAN	PURCHASE	11.07	1.8K	19.94K	1.8K
Jul 22, 2019	SONSINI PETER W.	PURCHASE	15.00	450K	6.75M	4.19M
Jul 22, 2019	SANDELL SCOTT D	PURCHASE	15.00	450K	6.75M	4.19M
Jul 22, 2019	MOTT DAVID M	PURCHASE	15.00	450K	6.75M	4.19M
Jul 22, 2019	O'DONNELL NIALL	PURCHASE	15.00	300K	4.5M	1.92M
Jul 22, 2019	MAKOWER JOSHUA	PURCHASE	15.00	450K	6.75M	4.19M
Jul 22, 2019	NOVO HOLDINGS A/S	PURCHASE	15.00	575K	8.63M	2.45M
Jul 22, 2019	FLYNN JAMES E	PURCHASE	15.00	166K	2.49M	166K
Jul 22, 2019	HERON PATRICK J	PURCHASE	15.00	450K	6.75M	3.57M
Jul 22, 2019	FRAZIER LIFE SCIENCES IX, L.P.	PURCHASE	15.00	450K	6.75M	3.57M
Jul 22, 2019	CHANG CARMEN	PURCHASE	15.00	450K	6.75M	4.19M
Jul 22, 2019	FLORENCE ANTHONY A. JR.	PURCHASE	15.00	450K	6.75M	4.19M
Jul 22, 2019	MAKHZOUMI MOHAMAD	PURCHASE	15.00	450K	6.75M	4.19M
Jul 22, 2019	NEW ENTERPRISE ASSOCIATES 16, L.P.	PURCHASE	15.00	450K	6.75M	4.19M
Jul 22, 2019	BARRIS PETER J	PURCHASE	15.00	450K	6.75M	4.19M
Jul 22, 2019	BASKETT FOREST	PURCHASE	15.00	450K	6.75M	4.19M
Jul 22, 2019	BEHBAHANI ALI	PURCHASE	15.00	450K	6.75M	4.19M
Jul 22, 2019	WALKER PAUL EDWARD	PURCHASE	15.00	450K	6.75M	4.19M

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE131.43K1

SALES216.21K22

NET SHARES-84.78K21

SHARES HELD1.19M23

% NET SHARES-107.1%-8.7%

Frequently Asked Questions

Stock Outstanding Shares

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares13.25

Short Percent Of Float13.25

Shares Outstanding50.24M

Shares Float39.99M

Shares Short6.63M

Short Ratio17.23

13.25%

Short % of Float

13.25%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

1.86% Percentage of Shares held by All Insiders

114.07% Percentage of Shares held by All Institutions

116.24% Percentage of Float held by Institutions

299

Number of Institutions Holding Shares

Institutional Ownership

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	BVF INC/IL	2.57%	1.5M	118.11M	0	0
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	0.42%	244.27K	19.3M	-64.76K	-20.96%
Dec 31, 2025	FRANKLIN RESOURCES INC	1.12%	650.72K	51.4M	49.58K	+8.25%
Dec 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.8%	467.47K	36.93M	-30K	-6.03%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.97%	565.58K	44.68M	120.05K	+26.95%
Dec 31, 2025	WOODLINE PARTNERS LP	0.98%	567.89K	44.86M	0	0
Dec 31, 2025	FMR LLC	1.11%	646.47K	51.06M	6.25K	+0.98%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	1.13%	655.78K	51.8M	54.71K	+9.10%
Dec 31, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	1.31%	762.29K	60.21M	1.17K	+0.15%
Dec 31, 2025	POLAR CAPITAL HOLDINGS PLC	1.37%	793.64K	62.69M	-26.91K	-3.28%
Dec 31, 2025	D. E. SHAW & CO., INC.	1.63%	948.16K	74.9M	24.65K	+2.67%
Dec 31, 2025	NOVO HOLDINGS A/S	2.18%	1.26M	99.85M	0	0
Dec 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.44%	1.42M	112.2M	137.09K	+10.68%
Dec 31, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	11.7%	6.8M	536.75M	0	0
Dec 31, 2025	ESSEX INVESTMENT MANAGEMENT CO LLC	0.19%	111.31K	8.79M	-2.15K	-1.89%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.2%	115.44K	9.12M	88.37K	+326.52%
Dec 31, 2025	HIGHLANDER PARTNERS, L.P.	0.21%	122.98K	9.71M	0	0
Dec 31, 2025	ENSIGN PEAK ADVISORS, INC	0.23%	133.97K	10.58M	0	0
Dec 31, 2025	FIRST TRUST ADVISORS LP	0.24%	137.7K	10.88M	-6.55K	-4.54%
Dec 31, 2025	BARCLAYS PLC	0.24%	142.14K	11.23M	26.37K	+22.78%
Dec 31, 2025	CITIGROUP INC	0.25%	145.99K	11.53M	-1.26K	-0.86%
Dec 31, 2025	LEGAL & GENERAL GROUP PLC	0.29%	168.39K	13.3M	1.16K	+0.70%
Dec 31, 2025	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	0.44%	257.23K	20.32M	257.23K	+100.00%
Dec 31, 2025	NORGES BANK	0.45%	263.18K	20.79M	263.18K	+100.00%
Dec 31, 2025	PENN CAPITAL MANAGEMENT COMPANY, LLC	0.49%	281.92K	22.32M	-26.07K	-8.47%
Dec 31, 2025	TANG CAPITAL MANAGEMENT LLC	2.13%	1.24M	97.63M	0	0
Dec 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	2.13%	1.24M	97.78M	447.14K	+56.55%
Dec 31, 2025	JANUS HENDERSON GROUP PLC	10.44%	6.07M	479.05M	1.07M	+21.36%
Dec 31, 2025	UBS GROUP AG	0.55%	320.78K	25.34M	44.94K	+16.29%
Dec 31, 2025	WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	0.58%	336.7K	26.6M	23.44K	+7.48%
Dec 31, 2025	EMERALD ADVISERS, LLC	0.63%	367.13K	29M	-2.47K	-0.67%
Dec 31, 2025	NEXT CENTURY GROWTH INVESTORS LLC	0.63%	368.04K	29.07M	7.1K	+1.97%
Dec 31, 2025	TWO SIGMA INVESTMENTS, LP	0.67%	388.54K	30.69M	45.42K	+13.24%
Dec 31, 2025	TIMESSQUARE CAPITAL MANAGEMENT, LLC	0.68%	395.83K	31.27M	95.18K	+31.66%
Dec 31, 2025	NUVEEN, LLC	0.87%	503.05K	39.74M	-98.63K	-16.39%
Dec 31, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.99%	573.61K	45.31M	424.92K	+285.76%
Dec 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.99%	577.27K	45.6M	36K	+6.65%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	1.23%	713.45K	56.36M	322.98K	+82.71%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	1.25%	724.32K	57.21M	273.48K	+60.66%
Dec 31, 2025	CITADEL ADVISORS LLC	1.45%	840.22K	66.37M	-200.32K	-19.25%
Dec 31, 2025	EVENTIDE ASSET MANAGEMENT, LLC	3.6%	2.09M	165.37M	-428.98K	-17.01%
Dec 31, 2025	STATE STREET CORP	3.69%	2.14M	169.35M	797.09K	+59.18%
Dec 31, 2025	VANGUARD GROUP INC	4.47%	2.6M	205.07M	50.72K	+1.99%
Dec 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.49%	285.87K	22.58M	-31.28K	-9.86%
Dec 31, 2025	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.51%	297.95K	23.54M	-91.62K	-23.52%
Dec 31, 2025	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	0.64%	372.51K	29.42M	-239.81K	-39.16%
Dec 31, 2025	NORTHERN TRUST CORP	0.65%	374.86K	29.61M	-10.47K	-2.72%
Dec 31, 2025	BOONE CAPITAL MANAGEMENT LLC	0.72%	421.24K	33.27M	-114.5K	-21.37%
Dec 31, 2025	MACQUARIE MANAGEMENT HOLDINGS, INC.	0.73%	421.85K	33.32B	421.85K	+100.00%
Dec 31, 2025	MORGAN STANLEY	0.73%	425.69K	33.62M	-244.46K	-36.48%
Dec 31, 2025	SQUAREPOINT OPS LLC	0.3%	172.43K	13.62M	44.52K	+34.81%
Dec 31, 2025	SEGALL BRYANT & HAMILL, LLC	0.32%	185.02K	14.62M	185.02K	+100.00%
Dec 31, 2025	DEUTSCHE BANK AG\	0.32%	186.71K	14.75M	2.38K	+1.29%
Dec 31, 2025	NICHOLAS INVESTMENT PARTNERS, LP	0.37%	213.39K	16.86M	-3.68K	-1.69%
Dec 31, 2025	HANDELSBANKEN FONDER AB	0.37%	213.5K	16.86M	213.5K	+100.00%
Dec 31, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.37%	217.61K	17.19M	-25.78K	-10.59%
Dec 31, 2025	LOGOS GLOBAL MANAGEMENT LP	0.39%	225K	17.77M	225K	+100.00%
Dec 31, 2025	NAN FUNG TRINITY (HK) LTD	0.39%	227.48K	17.97M	71.21K	+45.57%
Dec 31, 2025	TWO SIGMA ADVISERS, LP	0.4%	232.1K	18.33M	-44.3K	-16.03%
Dec 31, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.42%	242.32K	19.14M	23.28K	+10.63%
Dec 31, 2025	RAYMOND JAMES FINANCIAL INC	0.42%	246.42K	19.46M	-5.32K	-2.11%
Dec 31, 2025	ERSTE ASSET MANAGEMENT GMBH	0.43%	250K	19.78M	0	0
Dec 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.76%	439.09K	34.68M	-74.36K	-14.48%
Dec 31, 2025	PATIENT SQUARE CAPITAL LP	0.51%	298.68K	23.59M	194.42K	+186.47%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.7%	409.29K	32.33M	14.8K	+3.75%
Dec 31, 2025	FIRST TURN MANAGEMENT, LLC	0.83%	481.56K	38.04M	-89.01K	-15.60%
Dec 31, 2025	FEDERATED HERMES, INC.	0.83%	481.96K	38.07M	135.44K	+39.09%
Dec 31, 2025	LOOMIS SAYLES & CO L P	0.89%	514.98K	40.68M	-24.06K	-4.46%
Dec 31, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.9%	521.65K	41.21M	25.68K	+5.18%
Dec 31, 2025	CANDRIAM S.C.A.	0.98%	569.59K	44.99M	166.56K	+41.33%
Dec 31, 2025	LORD, ABBETT & CO. LLC	1%	579.98K	45.81M	-81.96K	-12.38%
Dec 31, 2025	CLEARBRIDGE INVESTMENTS, LLC	1.49%	865.97K	68.4M	-137.84K	-13.73%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.83%	1.06M	83.98M	52.9K	+5.24%
Dec 31, 2025	BLACKROCK, INC.	6.27%	3.65M	287.94M	42.85K	+1.19%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.49%	243.39K	17.84M	-6.47K	-2.59%
Sep 30, 2025	BVF INC/IL	2.57%	1.5M	109.62M	-1.27M	-45.85%
Sep 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	4.34%	2.52M	184.92M	-114.92K	-4.36%
Sep 30, 2025	VANGUARD GROUP INC	4.38%	2.55M	186.6M	-19.5K	-0.76%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.53%	309.03K	22.66M	20.87K	+7.24%
Sep 30, 2025	NEXT CENTURY GROWTH INVESTORS LLC	0.62%	360.93K	26.46M	170.61K	+89.64%
Sep 30, 2025	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.67%	389.57K	28.56M	372K	+2,116.64%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.77%	445.53K	32.66M	-50.53K	-10.19%
Sep 30, 2025	CALAMOS ADVISORS LLC	0.09%	43.25K	3.17M	9.99K	+30.02%
Sep 30, 2025	SECURE ASSET MANAGEMENT, LLC	0.1%	48.44K	3.54M	-2.56K	-5.01%
Sep 30, 2025	JANUS HENDERSON GROUP PLC	8.6%	5M	366.52M	-238.69K	-4.56%
Sep 30, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	11.7%	6.8M	498.15M	0	0
Sep 30, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.85%	495.98K	36.36M	72.23K	+17.05%
Sep 30, 2025	PRUDENTIAL FINANCIAL INC	0.11%	54.19K	3.97M	44.54K	+461.79%
Sep 30, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.11%	56.26K	4.12M	-9.5K	-14.45%
Sep 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.93%	541.28K	39.68M	-159.88K	-22.80%
Sep 30, 2025	NOVO HOLDINGS A/S	2.18%	1.26M	92.67M	-236.03K	-15.73%
Sep 30, 2025	NORTHERN TRUST CORP	0.66%	385.34K	28.25M	-17.06K	-4.24%
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.59%	343.13K	25.15M	171.31K	+99.71%
Sep 30, 2025	CITADEL ADVISORS LLC	1.79%	1.04M	76.28M	-365.81K	-26.01%
Sep 30, 2025	TANG CAPITAL MANAGEMENT LLC	2.13%	1.24M	90.61M	0	0
Sep 30, 2025	STATE STREET CORP	2.32%	1.35M	98.74M	-28.72K	-2.09%
Sep 30, 2025	BOONE CAPITAL MANAGEMENT LLC	0.92%	535.73K	39.27M	-105.72K	-16.48%
Sep 30, 2025	BANK OF MONTREAL /CAN/	0.11%	57.04K	4.18M	0	0
Sep 30, 2025	RHUMBLINE ADVISERS	0.12%	59.07K	4.33M	-5.53K	-8.56%
Sep 30, 2025	SWISS NATIONAL BANK	0.14%	72K	5.28M	1.8K	+2.56%
Sep 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.16%	78.9K	5.78M	12.11K	+18.13%
Sep 30, 2025	HEALTHINVEST PARTNERS AB	0.19%	93.61K	728.52K	-13.31K	-12.45%
Sep 30, 2025	JPMORGAN CHASE & CO	0.2%	100.21K	7.35M	-380.07K	-79.14%
Sep 30, 2025	INVESCO LTD.	0.2%	101.47K	7.44M	36.82K	+56.95%
Sep 30, 2025	PATIENT SQUARE CAPITAL LP	0.21%	104.26K	7.64M	-9.2K	-8.11%
Sep 30, 2025	ESSEX INVESTMENT MANAGEMENT CO LLC	0.23%	113.46K	8.32M	727	+0.64%
Sep 30, 2025	BARCLAYS PLC	0.23%	115.77K	8.49M	-39.1K	-25.25%
Sep 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.23%	115.85K	8.49M	-6.92K	-5.63%
Sep 30, 2025	HIGHLANDER PARTNERS, L.P.	0.25%	122.98K	9.02M	0	0
Sep 30, 2025	ENSIGN PEAK ADVISORS, INC	0.27%	133.97K	9.82M	0	0
Sep 30, 2025	FIRST TRUST ADVISORS LP	0.29%	144.25K	10.57M	14.45K	+11.14%
Sep 30, 2025	CITIGROUP INC	0.3%	147.25K	10.8M	76.55K	+108.26%
Sep 30, 2025	NAN FUNG TRINITY (HK) LTD	0.31%	156.27K	11.46M	9.5K	+6.47%
Sep 30, 2025	JUMP FINANCIAL, LLC	0.33%	162.1K	11.88M	13.41K	+9.02%
Sep 30, 2025	RICE HALL JAMES & ASSOCIATES, LLC	0.33%	164.75K	12.08M	-67.25K	-28.99%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.34%	167.23K	12.26M	124.22K	+288.82%
Sep 30, 2025	DEUTSCHE BANK AG\	0.37%	184.33K	13.51M	28.7K	+18.44%
Sep 30, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.44%	219.04K	16.06M	1.5K	+0.69%
Sep 30, 2025	TIMESSQUARE CAPITAL MANAGEMENT, LLC	0.52%	300.65K	22.04M	300.65K	+100.00%
Sep 30, 2025	PENN CAPITAL MANAGEMENT COMPANY, LLC	0.53%	307.99K	22.63M	-34.27K	-10.01%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.55%	317.15K	23.25M	317.15K	+100.00%
Sep 30, 2025	BLACKROCK, INC.	6.2%	3.6M	264.09M	25.34K	+0.71%
Sep 30, 2025	FEDERATED HERMES, INC.	0.6%	346.52K	25.4M	2.22K	+0.64%
Sep 30, 2025	WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	0.54%	313.26K	22.97M	313.26K	+100.00%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	0.78%	450.84K	33.05M	55.83K	+14.13%
Sep 30, 2025	LORD, ABBETT & CO. LLC	1.14%	661.94K	48.53M	-109.21K	-14.16%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.56%	278.76K	20.44M	31.03K	+12.53%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.88%	513.45K	37.64M	117.1K	+29.54%
Sep 30, 2025	LOOMIS SAYLES & CO L P	0.93%	539.04K	39.52M	-13.92K	-2.52%
Sep 30, 2025	WOODLINE PARTNERS LP	0.98%	567.89K	41.63M	0	0
Sep 30, 2025	FIRST TURN MANAGEMENT, LLC	0.98%	570.57K	41.83M	43.03K	+8.16%
Sep 30, 2025	EMERALD ADVISERS, LLC	0.64%	369.6K	27.1M	63.83K	+20.88%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.86%	497.47K	36.47M	254.47K	+104.72%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	1.03%	601.07K	44.06M	119.61K	+24.84%
Sep 30, 2025	FRANKLIN RESOURCES INC	1.03%	601.14K	44.07M	7.54K	+1.27%
Sep 30, 2025	NUVEEN, LLC	1.04%	601.67K	44.11M	11.41K	+1.93%
Sep 30, 2025	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	1.05%	612.32K	44.89M	536.67K	+709.47%
Sep 30, 2025	FMR LLC	1.1%	640.22K	46.93M	580.78K	+977.06%
Sep 30, 2025	MORGAN STANLEY	1.15%	670.15K	49.13M	103.82K	+18.33%
Sep 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	1.31%	761.13K	55.8M	-57.08K	-6.98%
Sep 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	1.36%	790.68K	57.96M	531.81K	+205.44%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	1.36%	790.69K	57.97M	672.12K	+566.85%
Sep 30, 2025	POLAR CAPITAL HOLDINGS PLC	1.41%	820.55K	60.15M	-154.45K	-15.84%
Sep 30, 2025	D. E. SHAW & CO., INC.	1.59%	923.51K	67.7M	368.55K	+66.41%
Sep 30, 2025	CLEARBRIDGE INVESTMENTS, LLC	1.73%	1M	73.59M	-23.72K	-2.31%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.74%	1.01M	74.06M	-19.59K	-1.90%
Sep 30, 2025	UBS GROUP AG	0.55%	275.84K	20.22M	93.39K	+51.18%
Sep 30, 2025	TWO SIGMA ADVISERS, LP	0.56%	276.4K	20.26M	105K	+61.26%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.79%	390.47K	28.63M	1.2K	+0.31%
Sep 30, 2025	MACQUARIE GROUP LTD	0.68%	393.21K	28.83M	-42.51K	-9.76%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.21%	1.28M	94.08M	-133.93K	-9.45%
Sep 30, 2025	AXA INVESTMENT MANAGERS S.A.	0.51%	255.69K	18.74M	255.69K	+100.00%
Sep 30, 2025	JANE STREET GROUP, LLC	0.51%	254.49K	18.66B	233.05K	+1,087.07%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.68%	394.49K	28.92M	11.33K	+2.96%
Sep 30, 2025	CANDRIAM S.C.A.	0.69%	403.03K	29.55M	30.02K	+8.05%
Sep 30, 2025	RAYMOND JAMES FINANCIAL INC	0.51%	251.73K	18.45M	-12.39K	-4.69%
Sep 30, 2025	ERSTE ASSET MANAGEMENT GMBH	0.5%	250K	18.21M	-10K	-3.85%
Jun 30, 2025	STATE STREET CORP	2.77%	1.38M	70.01M	-118.94K	-7.96%
Jun 30, 2025	RAYMOND JAMES FINANCIAL INC	0.53%	264.12K	13.44M	14.8K	+5.94%
Jun 30, 2025	RICE HALL JAMES & ASSOCIATES, LLC	0.47%	231.99K	11.81M	-2.7K	-1.15%
Jun 30, 2025	FMR LLC	0.12%	59.44K	3.02B	5.11K	+9.41%
Jun 30, 2025	BLACKROCK, INC.	7.19%	3.58M	182.04M	237.53K	+7.11%
Jun 30, 2025	PROSIGHT MANAGEMENT, LP	0.4%	200K	10.18M	-143.33K	-41.75%
Jun 30, 2025	ALGERT GLOBAL LLC	0.32%	159.35K	8.11M	92.59K	+138.69%
Jun 30, 2025	ESSEX INVESTMENT MANAGEMENT CO LLC	0.23%	112.73K	5.74M	112.73K	+100.00%
Jun 30, 2025	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	0.15%	75.64K	3.85M	75.64K	+100.00%
Jun 30, 2025	PALO ALTO INVESTORS LP	0.13%	64.7K	3.29M	0	0
Jun 30, 2025	SECURE ASSET MANAGEMENT, LLC	0.1%	51K	2.6M	2.09K	+4.27%
Jun 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.07%	37.21K	1.89M	-14.65K	-28.25%
Jun 30, 2025	AQUATIC CAPITAL MANAGEMENT LLC	0.07%	36.9K	1.88M	-9.41K	-20.33%
Jun 30, 2025	WOODLINE PARTNERS LP	1.14%	567.89K	28.9M	1.62K	+0.29%
Jun 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.41%	701.16K	35.68M	-77.09K	-9.91%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.77%	383.16K	19.5M	55.28K	+16.86%
Jun 30, 2025	CANDRIAM S.C.A.	0.75%	373.01K	18.98M	-9.97K	-2.60%
Jun 30, 2025	FEDERATED HERMES, INC.	0.69%	344.3K	17.52M	-3.06K	-0.88%
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.52%	258.87K	13.17M	26.77K	+11.53%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.49%	243K	12.37M	-102K	-29.57%
Jun 30, 2025	AMERIPRISE FINANCIAL INC	0.49%	242.76K	12.35M	46.88K	+23.93%
Jun 30, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	13.66%	6.8M	345.8M	0	0
Jun 30, 2025	BOONE CAPITAL MANAGEMENT LLC	1.29%	641.45K	32.64M	38.13K	+6.32%
Jun 30, 2025	MORGAN STANLEY	1.14%	566.33K	28.82M	-40.11K	-6.61%
Jun 30, 2025	PENN CAPITAL MANAGEMENT COMPANY, LLC	0.69%	342.26K	17.46M	-31.26K	-8.37%
Jun 30, 2025	NEXT CENTURY GROWTH INVESTORS LLC	0.38%	190.33K	9.69M	-5.02K	-2.57%
Jun 30, 2025	NICHOLAS INVESTMENT PARTNERS, LP	0.37%	184.48K	9.39M	11.44K	+6.61%
Jun 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.32%	159.03K	8.09M	19.59K	+14.05%
Jun 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.25%	122.77K	6.25M	-24.42K	-16.59%
Jun 30, 2025	HEALTHINVEST PARTNERS AB	0.22%	106.91K	5.44M	29.65K	+38.37%
Jun 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	5.3%	2.64M	134.22M	110.49K	+4.37%
Jun 30, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.44%	217.54K	11.07M	217.54K	+100.00%
Jun 30, 2025	JUMP FINANCIAL, LLC	0.3%	148.69K	7.57M	132.87K	+839.70%
Jun 30, 2025	NAN FUNG TRINITY (HK) LTD	0.3%	146.77K	7.47M	146.77K	+100.00%
Jun 30, 2025	PDT PARTNERS, LLC	0.29%	145.38K	7.4M	7.88K	+5.73%
Jun 30, 2025	SILVERCREST ASSET MANAGEMENT GROUP LLC	0.27%	135.92K	6.92M	0	0
Jun 30, 2025	ENSIGN PEAK ADVISORS, INC	0.27%	133.97K	6.82M	0	0
Jun 30, 2025	HIGHLANDER PARTNERS, L.P.	0.25%	122.98K	6.26M	0	0
Jun 30, 2025	PATIENT SQUARE CAPITAL LP	0.23%	113.46K	5.77M	-2.9K	-2.49%
Jun 30, 2025	TREXQUANT INVESTMENT LP	0.21%	104.3K	5.31M	104.3K	+100.00%
Jun 30, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.13%	65.76K	3.35M	-8K	-10.85%
Jun 30, 2025	BVF INC/IL	5.55%	2.76M	140.52M	-35.18K	-1.26%
Jun 30, 2025	NOVO HOLDINGS A/S	3.02%	1.5M	76.34M	55	0.00%
Jun 30, 2025	CLEARBRIDGE INVESTMENTS, LLC	2.07%	1.03M	52.29M	49.46K	+5.06%
Jun 30, 2025	POLAR CAPITAL HOLDINGS PLC	1.96%	975K	49.62M	-200K	-17.02%
Jun 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	1.65%	818.21K	41.64M	-133.56K	-14.03%
Jun 30, 2025	EMERALD ADVISERS, LLC	0.61%	305.77K	15.56M	305.77K	+100.00%
Jun 30, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.6%	298.7K	15.2M	298.7K	+100.00%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.58%	288.16K	14.66M	-191.14K	-39.88%
Jun 30, 2025	D. E. SHAW & CO., INC.	1.12%	554.96K	28.24M	11.68K	+2.15%
Jun 30, 2025	LOOMIS SAYLES & CO L P	1.11%	552.96K	28.14M	-13.2K	-2.33%
Jun 30, 2025	FIRST TURN MANAGEMENT, LLC	1.06%	527.54K	26.85M	24.53K	+4.88%
Jun 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.97%	481.46K	24.5M	-17.72K	-3.55%
Jun 30, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.85%	423.74K	21.56M	67.47K	+18.94%
Jun 30, 2025	AXA S.A.	0.71%	351.68K	17.9M	310	+0.09%
Jun 30, 2025		0.52%	260K	13.24M	0	0
Jun 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.5%	249.86K	12.72M	-10.51K	-4.04%
Jun 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.5%	247.73K	12.61M	18.28K	+7.97%
Jun 30, 2025	EVERSEPT PARTNERS, LP	0.47%	232.18K	11.82M	232.18K	+100.00%
Jun 30, 2025	JANUS HENDERSON GROUP PLC	10.53%	5.24M	266.48M	470.17K	+9.86%
Jun 30, 2025	VANGUARD GROUP INC	5.16%	2.56M	130.53M	24.81K	+0.98%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.85%	1.42M	72.12M	2.08K	+0.15%
Jun 30, 2025	CITADEL ADVISORS LLC	2.83%	1.41M	71.57M	-39.64K	-2.74%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.07%	1.03M	52.4M	65.95K	+6.84%
Jun 30, 2025	LORD, ABBETT & CO. LLC	1.55%	771.15K	39.24M	-42.25K	-5.19%
Jun 30, 2025	FRANKLIN RESOURCES INC	1.19%	593.6K	30.21M	241	+0.04%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	1%	496.06K	25.24M	249.33K	+101.05%
Jun 30, 2025	JPMORGAN CHASE & CO	0.97%	480.28K	24.44M	192.34K	+66.80%
Jun 30, 2025	MACQUARIE GROUP LTD	0.88%	435.72K	22.17M	68.97K	+18.80%
Jun 30, 2025	NORTHERN TRUST CORP	0.81%	402.4K	20.48M	13.48K	+3.46%
Jun 30, 2025	NUVEEN, LLC	1.19%	590.26K	30.04M	-64.47K	-9.85%
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.8%	396.35K	20.17M	207.85K	+110.26%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.79%	395.01K	20.1M	-82.64K	-17.30%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.78%	389.27K	19.81M	10.65K	+2.81%
Jun 30, 2025	ERSTE ASSET MANAGEMENT GMBH	0.52%	260K	13.24M	0	0
Jun 30, 2025	TANG CAPITAL MANAGEMENT LLC	2.49%	1.24M	62.9M	-1.08K	-0.09%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.77%	378.62K	17.06M	-64.01K	-14.46%
Mar 31, 2025	CANDRIAM S.C.A.	0.78%	382.98K	17.25M	-46.75K	-10.88%
Mar 31, 2025	NORTHERN TRUST CORP	0.8%	388.92K	17.52M	-10.62K	-2.66%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.98%	477.65K	21.52M	-77.99K	-14.04%
Mar 31, 2025	FIRST TURN MANAGEMENT, LLC	1.03%	503.01K	22.66M	-3.89K	-0.77%
Mar 31, 2025	LOOMIS SAYLES & CO L P	1.16%	566.16K	25.51M	-11.87K	-2.05%
Mar 31, 2025	FRANKLIN RESOURCES INC	1.21%	593.36K	26.73M	2.69K	+0.46%
Mar 31, 2025	MORGAN STANLEY	1.24%	606.43K	27.32M	-151.95K	-20.04%
Mar 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.59%	778.24K	35.06M	-81.85K	-9.52%
Mar 31, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.53%	260.37K	11.73M	32.02K	+14.02%
Mar 31, 2025	D. E. SHAW & CO., INC.	1.11%	543.28K	24.47M	385.93K	+245.26%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.98%	479.3K	21.59M	-47.68K	-9.05%
Mar 31, 2025	TANG CAPITAL MANAGEMENT LLC	2.53%	1.24M	55.73M	0	0
Mar 31, 2025	PENN CAPITAL MANAGEMENT COMPANY, LLC	0.76%	373.52K	16.87M	95.09K	+34.15%
Mar 31, 2025	CLEARBRIDGE INVESTMENTS, LLC	2%	978.07K	44.06M	70.75K	+7.80%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.89%	1.42M	63.75M	-7.59K	-0.53%
Mar 31, 2025	CITADEL ADVISORS LLC	2.96%	1.45M	65.14M	-65.19K	-4.31%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.5%	246.73K	11.12M	122.4K	+98.45%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.67%	327.88K	14.77M	-4.76K	-1.43%
Mar 31, 2025	STATE STREET CORP	3.06%	1.49M	67.33M	112.94K	+8.17%
Mar 31, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.47%	229.45K	10.34M	203.49K	+783.86%
Mar 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.47%	232.1K	10.46M	232.1K	+100.00%
Mar 31, 2025	RICE HALL JAMES & ASSOCIATES, LLC	0.48%	234.7K	10.57M	-4.3K	-1.80%
Mar 31, 2025	INVESCO LTD.	0.64%	313.42K	14.12M	14.14K	+4.73%
Mar 31, 2025	UBS GROUP AG	0.48%	235.96K	10.63M	51.37K	+27.83%
Mar 31, 2025	MACQUARIE GROUP LTD	0.75%	366.75K	16.52M	366.75K	+100.00%
Mar 31, 2025	WOODLINE PARTNERS LP	1.16%	566.27K	25.51M	161.87K	+40.03%
Mar 31, 2025	BOONE CAPITAL MANAGEMENT LLC	1.23%	603.32K	27.18M	21.48K	+3.69%
Mar 31, 2025	JANUS HENDERSON GROUP PLC	9.75%	4.77M	219.25M	184.47K	+4.03%
Mar 31, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	13.9%	6.8M	306.12M	224.73K	+3.42%
Mar 31, 2025		0.53%	260K	11.74M	0	0
Mar 31, 2025	PROSIGHT MANAGEMENT, LP	0.7%	343.33K	15.47M	-107.8K	-23.90%
Mar 31, 2025	RAYMOND JAMES FINANCIAL INC	0.51%	249.32K	11.23M	-7.29K	-2.84%
Mar 31, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.73%	356.28K	16.05M	179.32K	+101.33%
Mar 31, 2025	DEUTSCHE BANK AG\	0.49%	240.74K	10.85M	71.42K	+42.18%
Mar 31, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0.61%	296.89K	13.37M	212.92K	+253.57%
Mar 31, 2025	JPMORGAN CHASE & CO	0.59%	287.94K	12.97M	-97.21K	-25.24%
Mar 31, 2025	LORD, ABBETT & CO. LLC	1.66%	813.4K	36.64M	31.04K	+3.97%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.97%	963.67K	43.42M	20.32K	+2.15%
Mar 31, 2025	POLAR CAPITAL HOLDINGS PLC	2.4%	1.18M	52.93M	500K	+74.07%
Mar 31, 2025	BNP PARIBAS ARBITRAGE, SNC	1.02%	499.18K	22.49M	237.54K	+90.79%
Mar 31, 2025	BVF INC/IL	5.72%	2.8M	125.98M	0	0
Mar 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.71%	345K	15.54M	195K	+130.00%
Mar 31, 2025	FEDERATED HERMES, INC.	0.71%	347.37K	15.65M	343.73K	+9,440.40%
Mar 31, 2025	VANGUARD GROUP INC	5.2%	2.54M	114.43M	115.33K	+4.76%
Mar 31, 2025	AXA S.A.	0.72%	351.37K	15.83M	-74.27K	-17.45%
Mar 31, 2025	BLACKROCK, INC.	6.83%	3.34M	150.45M	-95.07K	-2.77%
Mar 31, 2025	EVENTIDE ASSET MANAGEMENT, LLC	5.17%	2.53M	113.85M	-79.94K	-3.07%
Mar 31, 2025	NOVO HOLDINGS A/S	3.07%	1.5M	67.58M	0	0
Mar 31, 2024	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.16%	64.42K	1.62M	31.24K	+94.14%
Mar 31, 2024	SCHRODER INVESTMENT MANAGEMENT GROUP	0.17%	67.5K	1.7M	0	0
Mar 31, 2024	PROPEL BIO MANAGEMENT, LLC	0.17%	70K	1.76M	0	0
Mar 31, 2024	SIMPLIFY ASSET MANAGEMENT INC.	0.17%	70K	1.76M	0	0
Mar 31, 2024	SILVERARC CAPITAL MANAGEMENT, LLC	0.19%	79.19K	1.99M	-1.62K	-2.00%
Mar 31, 2024	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.23%	92.25K	2.32M	92.25K	+100.00%
Mar 31, 2024	ALPHACENTRIC ADVISORS LLC	0.23%	94K	2.36M	44K	+88.00%
Mar 31, 2024	NAN FUNG GROUP HOLDINGS LTD	0.23%	96.1K	2.41M	0	0
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.24%	96.49K	2.42M	-20.79K	-17.73%
Mar 31, 2024	RAYMOND JAMES FINANCIAL SERVICES ADVISORS, INC.	0.24%	97.89K	2.46M	37.84K	+63.02%
Mar 31, 2024	KNIGHTS OF COLUMBUS ASSET ADVISORS LLC	0.25%	102.28K	2.57M	-14.37K	-12.32%
Mar 31, 2024	ABRDN PLC	0.27%	109.76K	2.76M	109.76K	+100.00%
Mar 31, 2024	CENTERBOOK PARTNERS LP	0.3%	122.46K	3.08M	70.62K	+136.23%
Mar 31, 2024	HIGHLANDER PARTNERS, L.P.	0.3%	122.98K	3.09M	0	0
Mar 31, 2024	HEALTHINVEST PARTNERS AB	0.3%	123K	3.09M	123K	+100.00%
Mar 31, 2024	RAYMOND JAMES & ASSOCIATES	0.32%	130.56K	3.28M	-5.12K	-3.77%
Mar 31, 2024	JPMORGAN CHASE & CO	0.36%	145.56K	3.66M	-41.02K	-21.99%
Mar 31, 2024	NICHOLAS INVESTMENT PARTNERS, LP	0.37%	151K	3.79M	-247.88K	-62.14%
Mar 31, 2024	UBS GROUP AG	0.38%	156.91K	3.94M	38.37K	+32.37%
Mar 31, 2024	AVIDITY PARTNERS MANAGEMENT LP	2.8%	1.14M	28.71M	0	0
Mar 31, 2024	VANGUARD GROUP INC	5.41%	2.21M	55.56M	-264.56K	-10.68%
Mar 31, 2024	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	15.89%	6.5M	163.16M	0	0
Mar 31, 2024	AFFINITY ASSET ADVISORS, LLC	0.39%	160K	4.02M	110K	+220.00%
Mar 31, 2024	ENSIGN PEAK ADVISORS, INC	0.54%	222.61K	5.59M	0	0
Mar 31, 2024	WOODLINE PARTNERS LP	0.57%	233.27K	5.86M	-20K	-7.90%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.59%	241.5K	6.07M	116.86K	+93.75%
Mar 31, 2024	DEUTSCHE BANK AG\	0.6%	244.15K	6.13M	72.63K	+42.34%
Mar 31, 2024	ARDSLEY ADVISORY PARTNERS LP	0.6%	245K	6.15M	20K	+8.89%
Mar 31, 2024	ELEQUIN SECURITIES, LLC	0.6%	245.7K	6.18M	245.6K	+264,089.25%
Mar 31, 2024	PENN CAPITAL MANAGEMENT COMPANY, LLC	0.6%	245.7K	6.18M	-32	-0.01%
Mar 31, 2024	CLEARBRIDGE INVESTMENTS, LLC	0.64%	263.58K	6.62M	-513	-0.19%
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	0.65%	266.26K	6.69M	135.92K	+104.27%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.66%	271.65K	6.82M	4.97K	+1.86%
Mar 31, 2024	BARCLAYS PLC	0.67%	274.87K	6.9M	174.94K	+175.08%
Mar 31, 2024	NORTHERN TRUST CORP	0.69%	281.08K	7.06M	-6.96K	-2.42%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.76%	311.19K	7.82M	-159.16K	-33.84%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.76%	312.61K	7.85M	161.79K	+107.27%
Mar 31, 2024	CITIGROUP INC	0.91%	371.05K	9.32M	285.82K	+335.35%
Mar 31, 2024	BOONE CAPITAL MANAGEMENT LLC	1.11%	451.9K	11.35M	-38.24K	-7.80%
Mar 31, 2024	PROSIGHT MANAGEMENT, LP	1.14%	465K	11.68M	171.7K	+58.54%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	1.32%	539.67K	13.56M	315.29K	+140.52%
Mar 31, 2024	AXA S.A.	1.45%	593.79K	14.92M	73	+0.01%
Mar 31, 2024	POLAR CAPITAL HOLDINGS PLC	1.53%	625K	15.7M	0	0
Mar 31, 2024	WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	1.53%	627.27K	15.76M	5.49K	+0.88%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	1.71%	697.14K	17.52M	15.96K	+2.34%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	1.71%	700.12K	17.59M	243.8K	+53.43%
Mar 31, 2024	FRANKLIN RESOURCES INC	2.3%	941.37K	23.65M	28.31K	+3.10%
Mar 31, 2024	PICTET ASSET MANAGEMENT HOLDING SA	2.34%	955.91K	24.01M	162.26K	+20.44%
Mar 31, 2024	FIRST TURN MANAGEMENT, LLC	2.34%	958.65K	24.08M	122.35K	+14.63%
Mar 31, 2024	CADIAN CAPITAL MANAGEMENT, LP	5.61%	2.29M	57.59M	357.65K	+18.48%
Mar 31, 2024	BLACKROCK INC.	6%	2.45M	61.6M	-9.48K	-0.39%
Mar 31, 2024	JANUS HENDERSON GROUP PLC	6.77%	2.77M	69.47M	704.66K	+34.16%
Mar 31, 2024	RICE HALL JAMES & ASSOCIATES, LLC	0.53%	214.89K	5.4M	172.05K	+401.60%
Mar 31, 2024	MORGAN STANLEY	0.87%	354.59K	8.91M	109.9K	+44.91%
Mar 31, 2024	CHECKPOINT CAPITAL L.P.	0.89%	362.19K	9.1M	128.53K	+55.01%
Mar 31, 2024	STATE STREET CORP	6.9%	2.82M	70.9M	1.09M	+62.70%
Mar 31, 2024	EVENTIDE ASSET MANAGEMENT, LLC	8.07%	3.3M	82.91M	636.75K	+23.91%
Mar 31, 2024	BVF INC/IL	10.69%	4.37M	109.78M	0	0
Mar 31, 2024	INVESCO LTD.	0.1%	39.02K	980.21K	-45.85K	-54.02%
Mar 31, 2024	PROFUND ADVISORS LLC	0.1%	40.86K	1.03B	19.69K	+93.03%
Mar 31, 2024	LOS ANGELES CAPITAL MANAGEMENT LLC	0.1%	41.84K	1.05M	4.07K	+10.77%
Mar 31, 2024	SECURE ASSET MANAGEMENT, LLC	0.1%	42.27K	1.06M	3.07K	+7.83%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.11%	44.19K	1.11M	5.67K	+14.71%
Mar 31, 2024	BANK OF MONTREAL /CAN/	0.11%	45.27K	1.32M	-4.52K	-9.08%
Mar 31, 2024	STATE OF WISCONSIN INVESTMENT BOARD	0.11%	45.82K	1.15M	17.09K	+59.49%
Mar 31, 2024	SWISS NATIONAL BANK	0.15%	59.3K	1.49M	0	0
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.15%	59.8K	1.5B	12.8K	+27.23%
Mar 31, 2024	PHOCAS FINANCIAL CORP.	0.15%	61.54K	1.55M	61.54K	+100.00%
Mar 31, 2024	HENNION & WALSH ASSET MANAGEMENT, INC.	0.16%	63.53K	1.6M	15.02K	+30.97%
Mar 31, 2024	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.39%	160K	4.02M	-415K	-72.17%
Mar 31, 2024	SILVERCREST ASSET MANAGEMENT GROUP LLC	0.4%	162.82K	4.09M	63.87K	+64.55%
Mar 31, 2024	BAKER BROS. ADVISORS LP	0.47%	190.48K	4.78M	0	0
Mar 31, 2024	NEW YORK STATE COMMON RETIREMENT FUND	0.48%	196.68K	4.94M	-26.19K	-11.75%
Mar 31, 2024	TWO SIGMA ADVISERS, LP	0.48%	197K	4.95M	-139.3K	-41.42%
Mar 31, 2024	ALTIUM CAPITAL MANAGEMENT LP	0.51%	208K	5.22M	208K	+100.00%
Mar 31, 2024	TANG CAPITAL MANAGEMENT LLC	2.9%	1.19M	29.82M	50K	+4.40%
Mar 31, 2024	CITADEL ADVISORS LLC	3.41%	1.39M	34.98M	-50.31K	-3.49%
Mar 31, 2024	NOVO HOLDINGS A/S	3.67%	1.5M	37.68M	0	0
Mar 31, 2024	PRICE T ROWE ASSOCIATES INC /MD/	3.91%	1.6M	40.13M	432.82K	+37.16%
Mar 31, 2024	ROCK SPRINGS CAPITAL MANAGEMENT LP	4.54%	1.86M	46.64M	5.1K	+0.28%
Dec 31, 2023	TWO SIGMA ADVISERS, LP	0.82%	336.3K	9.93M	-54.6K	-13.97%
Dec 31, 2023	PROSIGHT MANAGEMENT, LP	0.71%	293.3K	8.66M	-60.21K	-17.03%
Dec 31, 2023	NORTHERN TRUST CORP	0.7%	288.04K	8.5M	12.8K	+4.65%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.65%	266.68K	7.87M	42.11K	+18.75%
Dec 31, 2023	CLEARBRIDGE INVESTMENTS, LLC	0.64%	264.1K	7.8M	247.93K	+1,533.86%
Dec 31, 2023	WOODLINE PARTNERS LP	0.62%	253.26K	7.48M	-199.44K	-44.06%
Dec 31, 2023	PENN CAPITAL MANAGEMENT COMPANY, LLC	0.6%	245.73K	7.26M	-242	-0.10%
Dec 31, 2023	MORGAN STANLEY	0.6%	244.69K	7.22M	97.78K	+66.55%
Dec 31, 2023		0.57%	233.66K	6.9M	233.66K	+100.00%
Dec 31, 2023	ARDSLEY ADVISORY PARTNERS LP	0.55%	225K	6.64M	125K	+125.00%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	0.55%	224.38K	6.62M	87.97K	+64.49%
Dec 31, 2023	NEW YORK STATE COMMON RETIREMENT FUND	0.54%	222.86K	6.58M	918	+0.41%
Dec 31, 2023	ENSIGN PEAK ADVISORS, INC	0.54%	222.61K	6.57M	0	0
Dec 31, 2023	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	0.52%	211.95K	6.26M	111.95K	+111.95%
Dec 31, 2023	BLACKROCK INC.	5.99%	2.46M	72.67M	348.34K	+16.48%
Dec 31, 2023	VANGUARD GROUP INC	6.03%	2.48M	73.1M	782.9K	+46.23%
Dec 31, 2023	EVENTIDE ASSET MANAGEMENT, LLC	6.48%	2.66M	78.63M	-1.29M	-32.71%
Dec 31, 2023	BVF INC/IL	10.63%	4.37M	129M	0	0
Dec 31, 2023	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	15.8%	6.5M	191.74M	25K	+0.39%
Dec 31, 2023	TEACHER RETIREMENT SYSTEM OF TEXAS	0.33%	137.22K	4.05M	130.21K	+1,858.55%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.37%	150.82K	4.45M	28.18K	+22.97%
Dec 31, 2023	DEUTSCHE BANK AG\	0.42%	171.53K	5.06M	157.16K	+1,094.14%
Dec 31, 2023	JPMORGAN CHASE & CO	0.45%	186.58K	5.51M	86.81K	+87.00%
Dec 31, 2023	PATHWAY CAPITAL MANAGEMENT, LP	0.46%	190.29K	5.62M	190.29K	+100.00%
Dec 31, 2023	BAKER BROS. ADVISORS LP	0.46%	190.48K	5.62M	0	0
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	0.48%	196.13K	5.79M	-132.66K	-40.35%
Dec 31, 2023	FRANKLIN RESOURCES INC	2.22%	913.07K	26.95M	168.45K	+22.62%
Dec 31, 2023	TANG CAPITAL MANAGEMENT LLC	2.77%	1.14M	33.57M	0	0
Dec 31, 2023	AVIDITY PARTNERS MANAGEMENT LP	2.78%	1.14M	33.74M	0	0
Dec 31, 2023	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0.51%	211.11K	6.23M	183.8K	+672.93%
Dec 31, 2023	PRICE T ROWE ASSOCIATES INC /MD/	2.83%	1.16M	34.38M	1.13M	+3,544.30%
Dec 31, 2023	CITADEL ADVISORS LLC	3.51%	1.44M	42.59M	-274.45K	-15.98%
Dec 31, 2023	NOVO HOLDINGS A/S	3.65%	1.5M	44.28M	0	0
Dec 31, 2023	STATE STREET CORP	4.22%	1.73M	51.21M	113.87K	+7.02%
Dec 31, 2023	ROCK SPRINGS CAPITAL MANAGEMENT LP	4.5%	1.85M	54.66M	30.73K	+1.69%
Dec 31, 2023	CADIAN CAPITAL MANAGEMENT, LP	4.71%	1.93M	57.12M	500K	+34.85%
Dec 31, 2023	JANUS HENDERSON GROUP PLC	5.02%	2.06M	60.89M	138.79K	+7.21%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.66%	681.18K	20.11M	106.1K	+18.45%
Dec 31, 2023	POLAR CAPITAL HOLDINGS PLC	1.52%	625K	18.45M	-550K	-46.81%
Dec 31, 2023	WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	1.51%	621.78K	18.35M	88.09K	+16.50%
Dec 31, 2023	AXA S.A.	1.44%	593.71K	17.53M	-23.4K	-3.79%
Dec 31, 2023	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.4%	575K	16.97M	-90K	-13.53%
Dec 31, 2023	PERCEPTIVE ADVISORS LLC	1.3%	534.94K	15.79M	-137.1K	-20.40%
Dec 31, 2023	BOONE CAPITAL MANAGEMENT LLC	1.19%	490.14K	14.47M	100.35K	+25.74%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	1.14%	470.34K	13.88M	37.56K	+8.68%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	1.11%	456.32K	13.47M	215.54K	+89.52%
Dec 31, 2023	NICHOLAS INVESTMENT PARTNERS, LP	0.97%	398.88K	11.78M	-800.48K	-66.74%
Dec 31, 2023	SOFINNOVA INVESTMENTS, INC.	0.86%	352.4K	10.4M	343.31K	+3,777.18%

Insiders

Insiders	Designation	Shares Held
NEW ENTERPRISE ASSOCIATES 16, L.P.	10 percent owner	4.19M
WALKER PAUL EDWARD	10 percent owner	4.19M
SONSINI PETER W.	10 percent owner	4.19M
SANDELL SCOTT D	10 percent owner	4.19M
MOTT DAVID M	10 percent owner	4.19M
MAKOWER JOSHUA	10 percent owner	4.19M
MAKHZOUMI MOHAMAD	10 percent owner	4.19M
FLORENCE ANTHONY A. JR.	10 percent owner	4.19M
CHANG CARMEN	10 percent owner	4.19M
BASKETT FOREST	10 percent owner	4.19M
BARRIS PETER J	10 percent owner	4.19M
BEHBAHANI ALI	10 percent owner	4.19M
FRAZIER LIFE SCIENCES IX, L.P.	10 percent owner	3.57M
NOVO HOLDINGS A/S	10 percent owner	2.45M
O'DONNELL NIALL	director	1.62M
DEERFIELD HEALTHCARE INNOVATIONS FUND, L.P.		1.54M
FLYNN JAMES E	* Possible Member of 10% Group	1.54M
HERON PATRICK J	director	459.01K
PEETZ CHRISTOPHER	CHIEF EXECUTIVE OFFICER	160.29K
LONGPRE LARA	CHIEF DEVELOPMENT OFFICER	104.41K
TUCKER EDWIN JONATHAN	Chief Medical Officer	45.77K
BJERKHOLT ERIC	CHIEF FINANCIAL OFFICER	43.74K
VIG PAMELA	CHIEF SCIENTIFIC OFFICER	27.41K
RADOVICH PETER	PRESIDENT AND COO	20.66K
CLEMENTS IAN	Chief Financial Officer	18.56K
BREGE LAURA	director	15.7K
QUAN JOANNE	CHIEF MEDICAL OFFICER	12.82K
FISCHER LAURENT	director	6.75K
HOWE JOLANDA	SVP, GLOBAL CONTROLLER	4.5K
FAIREY WILLIAM	director	2.5K
GREY MICHAEL G	director	0
RAMASASTRY SAIRA	director	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Feb 13, 2026	RAMASASTRY SAIRA	SALE	102.09	2K	204.18K	0
Feb 02, 2026	HOWE JOLANDA	SALE	103.30	968	100K	4.5K
Feb 02, 2026	PEETZ CHRISTOPHER	SALE	103.30	9.11K	940.89K	160.29K
Feb 02, 2026	RADOVICH PETER	SALE	103.30	2.63K	271.79K	20.66K
Jan 26, 2026	HOWE JOLANDA	SALE	96.19	842	80.99K	3.7K
Jan 26, 2026	RADOVICH PETER	SALE	96.19	3.14K	302.33K	23.29K
Jan 26, 2026	BJERKHOLT ERIC	SALE	96.19	1.05K	101.29K	43.74K
Jan 26, 2026	PEETZ CHRISTOPHER	SALE	96.19	6.83K	657.09K	169.4K
Jan 23, 2026	HERON PATRICK J	PURCHASE	68.48	131.43K	9M	459.01K
Jan 22, 2026	BJERKHOLT ERIC	SALE	93.33	1.42K	132.62K	42.13K
Jan 22, 2026	PEETZ CHRISTOPHER	SALE	93.33	7.1K	662.42K	163.73K
Jan 22, 2026	RADOVICH PETER	SALE	93.33	2.38K	222.3K	20.68K
Jan 22, 2026	HOWE JOLANDA	SALE	93.33	926	86.42K	3.04K
Jan 22, 2026	QUAN JOANNE	SALE	93.33	1.82K	170.04K	12.82K
Jan 20, 2026	QUAN JOANNE	SALE	90.27	6.91K	623.85K	11.31K
Jan 15, 2026	RAMASASTRY SAIRA	SALE	90.99	2K	181.98K	0
Dec 22, 2025	RAMASASTRY SAIRA	SALE	80.00	5K	400K	0
Dec 19, 2025	GREY MICHAEL G	SALE	78.00	50K	3.9M	0
Dec 18, 2025	RAMASASTRY SAIRA	SALE	70.00	1K	70K	0
Dec 01, 2025	GREY MICHAEL G	SALE	74.00	50K	3.7M	0
Nov 21, 2025	GREY MICHAEL G	SALE	70.00	50K	3.5M	0
Sep 12, 2025	BJERKHOLT ERIC	SALE	76.01	9.58K	728.02K	39.95K
Sep 11, 2025	BREGE LAURA	SALE	75.07	1.49K	111.93K	15.7K
Sep 08, 2025	RAMASASTRY SAIRA	SALE	0.00	17K	-	0
Aug 11, 2025	BJERKHOLT ERIC	SALE	0.00	8K	-	28.24K
Aug 11, 2025	PEETZ CHRISTOPHER	SALE	62.00	40K	2.48M	138.64K
Aug 07, 2025	PEETZ CHRISTOPHER	SALE	55.25	40K	2.21M	138.64K
Aug 07, 2025	HOWE JOLANDA	SALE	58.00	10K	580K	2.43K
Jul 03, 2025	HOWE JOLANDA	SALE	49.08	477	23.41K	2.43K
Jul 02, 2025	HOWE JOLANDA	SALE	48.25	564	27.21K	2.9K
Jun 11, 2025	FAIREY WILLIAM	SALE	48.42	3.2K	155.09K	2.5K
Jun 03, 2025	RAMASASTRY SAIRA	SALE	45.74	2.5K	114.35K	0
Jun 02, 2025	RAMASASTRY SAIRA	SALE	46.20	5.7K	263.49K	0
Mar 18, 2025	HOWE JOLANDA	SALE	44.45	2.42K	107.34K	2.43K
Mar 17, 2025	HERON PATRICK J	PURCHASE	43.93	21	922.61	168.67K
Mar 17, 2025	HOWE JOLANDA	SALE	44.36	1.81K	80.11K	4.84K
Mar 17, 2025	RADOVICH PETER	SALE	44.21	7.88K	348.36K	18.67K
Mar 17, 2025	PEETZ CHRISTOPHER	SALE	44.21	27.28K	1.21M	138.64K
Mar 14, 2025	HERON PATRICK J	PURCHASE	44.11	528	23.29K	168.65K
Mar 11, 2025	HERON PATRICK J	PURCHASE	43.77	963	42.16K	168.12K
Mar 10, 2025	HERON PATRICK J	PURCHASE	42.66	758	32.34K	166.58K
Mar 07, 2025	HERON PATRICK J	PURCHASE	43.21	580	25.06K	165.83K
Mar 06, 2025	HERON PATRICK J	PURCHASE	43.89	1.34K	58.6K	165.25K
Mar 05, 2025	HERON PATRICK J	PURCHASE	44.55	267	11.89K	163.91K
Mar 04, 2025	HERON PATRICK J	PURCHASE	45.55	1.28K	58.26K	163.59K
Mar 04, 2025	RADOVICH PETER	SALE	45.74	1.17K	53.47K	12.11K
Mar 03, 2025	PEETZ CHRISTOPHER	SALE	47.19	20.61K	972.49K	115.92K
Feb 03, 2025	HOWE JOLANDA	SALE	48.22	1.06K	51.31K	4.23K
Feb 03, 2025	RADOVICH PETER	SALE	48.22	2.63K	126.68K	26.96K
Feb 03, 2025	PEETZ CHRISTOPHER	SALE	48.22	9.1K	438.92K	115.92K
Jan 24, 2025	RADOVICH PETER	SALE	47.92	3.18K	152.26K	29.59K
Jan 24, 2025	PEETZ CHRISTOPHER	SALE	47.92	6.84K	327.66K	125.02K
Jan 24, 2025	HOWE JOLANDA	SALE	47.92	902	43.23K	3.52K
Jan 17, 2025	QUAN JOANNE	SALE	45.86	6.97K	319.6K	5.65K
Jan 07, 2025	RADOVICH PETER	SALE	42.82	2K	85.54K	27.02K
Jan 07, 2025	PEETZ CHRISTOPHER	SALE	42.82	7.49K	320.64K	119.36K
Jan 07, 2025	HOWE JOLANDA	SALE	42.82	750	32.11K	2.93K
Nov 14, 2024	HOWE JOLANDA	SALE	47.10	2.5K	117.75K	2.43K
Sep 18, 2024	HERON PATRICK J	PURCHASE	37.40	115	4.3K	162.31K
Sep 06, 2024	HERON PATRICK J	PURCHASE	41.58	230	9.56K	162.19K
Jul 02, 2024	HOWE JOLANDA	SALE	34.00	375	12.75K	2.43K
Jun 24, 2024	VIG PAMELA	SALE	34.00	30.56K	1.04M	27.41K
Jun 05, 2024	RAMASASTRY SAIRA	SALE	25.68	5K	128.4K	0
Mar 27, 2024	BJERKHOLT ERIC	PURCHASE	24.80	2K	49.6K	14K
Mar 25, 2024	RADOVICH PETER	SALE	25.80	4.3K	111.02K	29.01K
Mar 18, 2024	BJERKHOLT ERIC	PURCHASE	25.80	2K	51.6K	12K
Feb 02, 2024	RADOVICH PETER	SALE	26.19	1.79K	46.88K	34.7K
Feb 02, 2024	PEETZ CHRISTOPHER	SALE	26.19	6.01K	157.49K	104.11K
Feb 02, 2024	VIG PAMELA	SALE	26.19	1.21K	31.8K	28.69K
Feb 02, 2024	HOWE JOLANDA	SALE	26.19	735	19.25K	1.76K
Feb 02, 2024	LONGPRE LARA	SALE	26.19	847	22.18K	104.41K
Jan 08, 2024	HOWE JOLANDA	SALE	28.04	528	14.8K	722
Jan 08, 2024	PEETZ CHRISTOPHER	SALE	28.03	5.21K	146.03K	110.13K
Jan 08, 2024	VIG PAMELA	SALE	28.03	1.41K	39.47K	29.91K
Jan 08, 2024	RADOVICH PETER	SALE	28.03	1.41K	39.47K	36.49K
Jan 08, 2024	LONGPRE LARA	SALE	28.04	1.02K	28.57K	105.25K
Dec 05, 2023	HOWE JOLANDA	SALE	32.40	2.5K	81K	0
Nov 09, 2023	HERON PATRICK J	PURCHASE	28.30	2.91K	82.35K	161.96K
Sep 14, 2023	GREY MICHAEL G	SALE	32.00	14.22K	454.91K	0
Sep 13, 2023	HERON PATRICK J	PURCHASE	31.02	2.63K	81.42K	159.05K
Sep 12, 2023	HERON PATRICK J	PURCHASE	30.60	3.75K	114.76K	156.43K
Sep 11, 2023	BJERKHOLT ERIC	PURCHASE	29.65	10K	296.49K	10K
Sep 11, 2023	HERON PATRICK J	PURCHASE	30.30	4.69K	142.03K	152.68K
Aug 31, 2023	HERON PATRICK J	PURCHASE	26.25	147.99K	3.88M	147.99K
Aug 25, 2023	HOWE JOLANDA	SALE	26.23	3.46K	90.74K	0
Jul 03, 2023	HOWE JOLANDA	SALE	25.65	915	23.47K	3.46K
Jul 03, 2023	PEETZ CHRISTOPHER	SALE	25.65	5.5K	141.01K	115.33K
Jul 03, 2023	LONGPRE LARA	SALE	25.65	1K	25.75K	105.84K
Jul 03, 2023	RADOVICH PETER	SALE	25.65	1.43K	36.55K	37.68K
Jul 03, 2023	VIG PAMELA	SALE	25.65	1.43K	36.55K	30.79K
Jun 08, 2023	GREY MICHAEL G	SALE	29.00	14.61K	423.63K	0
May 03, 2023	GREY MICHAEL G	SALE	28.00	14.61K	409.02K	0
Jan 09, 2023	PEETZ CHRISTOPHER	SALE	20.62	5.16K	106.39K	91.95K
Jan 09, 2023	LONGPRE LARA	SALE	20.62	1K	20.68K	104.37K
Jan 09, 2023	RADOVICH PETER	SALE	20.62	1.38K	28.44K	33.32K
Jan 09, 2023	VIG PAMELA	SALE	20.62	1.38K	28.44K	27.31K
Nov 15, 2022	O'DONNELL NIALL	SALE	19.69	93.77K	1.85M	1.62M
Nov 14, 2022	O'DONNELL NIALL	SALE	19.60	32.11K	629.42K	1.71M
Nov 11, 2022	O'DONNELL NIALL	SALE	19.99	174.12K	3.48M	1.75M
Jun 06, 2022	FLYNN JAMES E	SALE	24.47	6.24K	152.77K	1.54M
Jun 06, 2022	DEERFIELD HEALTHCARE INNOVATIONS FUND, L.P.	SALE	24.47	6.24K	152.77K	1.54M
Nov 26, 2021	CLEMENTS IAN	PURCHASE	13.90	750	10.43K	18.56K
Nov 24, 2021	CLEMENTS IAN	PURCHASE	14.40	700	10.08K	17.81K
Nov 24, 2021	PEETZ CHRISTOPHER	PURCHASE	14.40	7K	100.8K	28.03K
Oct 01, 2021	RADOVICH PETER	SALE	19.26	1.36K	26.26K	11.27K
Oct 01, 2021	TUCKER EDWIN JONATHAN	SALE	19.26	1.36K	26.26K	45.77K
Oct 01, 2021	LONGPRE LARA	SALE	19.26	961	18.51K	84.25K
Oct 01, 2021	CLEMENTS IAN	SALE	19.26	1.57K	30.31K	16.65K
Oct 01, 2021	PEETZ CHRISTOPHER	SALE	19.26	3.67K	70.71K	21.03K
Oct 01, 2021	VIG PAMELA	SALE	19.26	1.36K	26.26K	9.67K
Jul 09, 2021	FLYNN JAMES E	SALE	15.81	99.33K	1.57M	0
Jul 07, 2021	FLYNN JAMES E	SALE	15.87	6.84K	108.5K	99.33K
Jul 06, 2021	FLYNN JAMES E	SALE	16.20	49.24K	797.43K	106.16K
Jul 02, 2021	FLYNN JAMES E	SALE	17.01	10.6K	180.3K	155.4K
Dec 23, 2020	PEETZ CHRISTOPHER	PURCHASE	18.76	3K	56.28K	199.57K
Dec 23, 2020	CLEMENTS IAN	PURCHASE	18.55	908	16.84K	6.28K
Mar 20, 2020	TUCKER EDWIN JONATHAN	PURCHASE	11.90	2.5K	29.74K	6K
Mar 19, 2020	TUCKER EDWIN JONATHAN	PURCHASE	9.91	2K	19.82K	3.5K
Sep 17, 2019	FISCHER LAURENT	PURCHASE	9.37	1.65K	15.44K	6.75K
Sep 16, 2019	FISCHER LAURENT	PURCHASE	9.47	452	4.28K	5.1K
Sep 10, 2019	LONGPRE LARA	PURCHASE	10.64	965	10.27K	105.37K
Sep 10, 2019	FISCHER LAURENT	PURCHASE	10.29	960	9.88K	4.65K
Sep 10, 2019	BREGE LAURA	PURCHASE	11.22	10K	112.2K	10K
Sep 09, 2019	FISCHER LAURENT	PURCHASE	10.54	1.67K	17.6K	3.39K
Sep 09, 2019	PEETZ CHRISTOPHER	PURCHASE	10.90	2K	21.8K	194.25K
Sep 06, 2019	FISCHER LAURENT	PURCHASE	10.71	1.72K	18.43K	1.72K
Sep 06, 2019	PEETZ CHRISTOPHER	PURCHASE	10.91	4.75K	51.81K	192.25K
Sep 06, 2019	VIG PAMELA	PURCHASE	10.96	1.6K	17.54K	1.6K
Sep 06, 2019	CLEMENTS IAN	PURCHASE	11.07	1.8K	19.94K	1.8K
Jul 22, 2019	SONSINI PETER W.	PURCHASE	15.00	450K	6.75M	4.19M
Jul 22, 2019	SANDELL SCOTT D	PURCHASE	15.00	450K	6.75M	4.19M
Jul 22, 2019	MOTT DAVID M	PURCHASE	15.00	450K	6.75M	4.19M
Jul 22, 2019	O'DONNELL NIALL	PURCHASE	15.00	300K	4.5M	1.92M
Jul 22, 2019	MAKOWER JOSHUA	PURCHASE	15.00	450K	6.75M	4.19M
Jul 22, 2019	NOVO HOLDINGS A/S	PURCHASE	15.00	575K	8.63M	2.45M
Jul 22, 2019	FLYNN JAMES E	PURCHASE	15.00	166K	2.49M	166K
Jul 22, 2019	HERON PATRICK J	PURCHASE	15.00	450K	6.75M	3.57M
Jul 22, 2019	FRAZIER LIFE SCIENCES IX, L.P.	PURCHASE	15.00	450K	6.75M	3.57M
Jul 22, 2019	CHANG CARMEN	PURCHASE	15.00	450K	6.75M	4.19M
Jul 22, 2019	FLORENCE ANTHONY A. JR.	PURCHASE	15.00	450K	6.75M	4.19M
Jul 22, 2019	MAKHZOUMI MOHAMAD	PURCHASE	15.00	450K	6.75M	4.19M
Jul 22, 2019	NEW ENTERPRISE ASSOCIATES 16, L.P.	PURCHASE	15.00	450K	6.75M	4.19M
Jul 22, 2019	BARRIS PETER J	PURCHASE	15.00	450K	6.75M	4.19M
Jul 22, 2019	BASKETT FOREST	PURCHASE	15.00	450K	6.75M	4.19M
Jul 22, 2019	BEHBAHANI ALI	PURCHASE	15.00	450K	6.75M	4.19M
Jul 22, 2019	WALKER PAUL EDWARD	PURCHASE	15.00	450K	6.75M	4.19M

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE131.43K1

SALES216.21K22

NET SHARES-84.78K21

SHARES HELD1.19M23

% NET SHARES-107.1%-8.7%

MIRM Stock Ownership Breakdown