How many institutions own KYMR stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own KYMR shares is 294, representing 109.99% of the company's common stock.

Who are the major shareholders selling Kymera Therapeutics, Inc. stock?

DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C), in the last quarter, reduced its stake in KYMR by -12.36% restricting it's holding to 572.26 thousand shares of worth nearly $32.39M. PRICE T ROWE ASSOCIATES INC /MD/ also lessened -25.69% of the KYMR shares from its portfolio, reducing its holding to 5.1 million shares of worth $288.51M. ADAGE CAPITAL PARTNERS GP, L.L.C. also shunned KYMR shares holding by -21.76% last quarter which brought its holding to 238 thousand shares worth $13.47M.

Investors who are buying KYMR stock?

As per its latest 13F filing, CHARLES SCHWAB INVESTMENT MANAGEMENT INC increased its stake in KYMR by 2.45% in the last quarter. The institutional holder raised its holding to 439.83 thousand shares having worth more than $24.89M. FRONTIER CAPITAL MANAGEMENT CO LLC also added 5.34% more shares of KYMR to its portfolio, raising its holding to 518.06 thousand shares of worth $29.32M. FEDERATED HERMES, INC. also increased its KYMR shares holding by 100% which brought its holding to 558.7 thousand shares worth $31.62M.

KYMR's major insiders: who are they?

The insider with the most stakes in KYMR is Atlas Venture Fund X, L.P. , 10 percent owner at the company. Additionally, KYMR stock is highly held by BAKER BROS. ADVISORS LP and director Booth Bruce among others.

Did an insider recently sell KYMR stock?

Company executives, directors, and other insiders own 2.53% percent of Kymera Therapeutics, Inc.'s stock. Within the last six months, there have been 14 transaction(s) in which KYMR insiders have sold stock, totaling 255.5K shares. Insiders that have sold shares include MAINOLFI NELLO, ESPOSITO PAMELA, and BOOTH BRUCE.

Which insider recently purchased KYMR stock?

There have been 1 transaction(s) during the past 6-months in which Kymera Therapeutics, Inc. insiders have bought stock, totalling 167192 shares

How much of KYMR does insiders own?

Around 5.97M Kymera Therapeutics, Inc. shares are held by insiders, which represents about 2.53% of KYMR stock.

Who is the insider with the largest stake?

KYMR 10 percent owner, Atlas Venture Fund X, L.P. holds the largest portfolio of the company's shares. KYMR shares owned by Atlas total nearly 828.83 thousand.

Which institution holds the most shares in KYMR?

CHARLES SCHWAB INVESTMENT MANAGEMENT INC is the largest institutional owner in KYMR which holds 439.83 thousand shares worth $24.89M or 0.5% of the total KYMR shares outstanding followed by ROCK SPRINGS CAPITAL MANAGEMENT LP with ownership of 450.37 thousand shares representing 0.52% of the KYMR ownership. AJU IB INVESTMENT CO., LTD. is the third largest stakeholder with 457.06 thousand shares or 0.52% of the ownership worth more than $25.86M.

Is Kymera Therapeutics, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the KYMR is concerned, it is a stock which is optionable.

Is there a short position on KYMR's shares?

Number of KYMR shares short is 7.75M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding KYMR shares are there?

As of today, 71.50M shares of KYMR are outstanding.

Is there many float in KYMR stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, KYMR has 46.96M shares in float.

KYMR short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for KYMR is 12.29.

Kymera Therapeutics (KYMR) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares11.05

Short Percent Of Float13.7

Shares Outstanding71.50M

Shares Float46.96M

Shares Short7.75M

Short Ratio12.29

13.7%

Short % of Float

11.05%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

2.53% Percentage of Shares held by All Insiders

109.99% Percentage of Shares held by All Institutions

112.83% Percentage of Float held by Institutions

294

Number of Institutions Holding Shares

Institutional Ownership

About 109.99% of KYMR shares are held by financial institutions. CHARLES SCHWAB INVESTMENT MANAGEMENT INC is the top corporate investor, holding 439.83K shares valued at $24.89M. A 0.5% stake in Kymera Therapeutics, Inc. is owned by the company. ROCK SPRINGS CAPITAL MANAGEMENT LP owns 450.37K shares valued at $25.49M, which translates its holding of 0.52% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.5%	439.83K	24.89M	10.52K	+2.45%
Sep 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.52%	450.37K	25.49M	0	0
Sep 30, 2025	AJU IB INVESTMENT CO., LTD.	0.52%	457.06K	25.86M	0	0
Sep 30, 2025	FRONTIER CAPITAL MANAGEMENT CO LLC	0.59%	518.06K	29.32M	26.25K	+5.34%
Sep 30, 2025	FEDERATED HERMES, INC.	0.64%	558.7K	31.62M	558.7K	+100.00%
Sep 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.66%	572.26K	32.39M	-80.74K	-12.36%
Sep 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	0.74%	644.59K	36.48M	81.6K	+14.49%
Sep 30, 2025	CAPITAL RESEARCH GLOBAL INVESTORS	1.45%	1.26M	71.44M	0	0
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.46%	1.28M	72.28M	83.65K	+7.01%
Sep 30, 2025	DEER MANAGEMENT CO. LLC	0.37%	325.9K	18.45M	0	0
Sep 30, 2025	NEXTECH INVEST, LTD.	0.39%	340.91K	19.3M	0	0
Sep 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.4%	346.82K	19.78M	341.26K	+6,139.96%
Sep 30, 2025	SQUAREPOINT OPS LLC	0.4%	351.25K	19.88M	317.92K	+954.03%
Sep 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.99%	863.76K	48.89M	44.84K	+5.47%
Sep 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	1.08%	939.09K	53.15M	5.2K	+0.56%
Sep 30, 2025	JENNISON ASSOCIATES LLC	1.18%	1.03M	58.17M	202.71K	+24.57%
Sep 30, 2025	STATE STREET CORP	2.31%	2.02M	114.3M	465.02K	+29.92%
Sep 30, 2025	SIREN, L.L.C.	3.93%	3.43M	194.03M	0	0
Sep 30, 2025	BLACKROCK, INC.	5%	4.37M	247.08M	217.19K	+5.24%
Sep 30, 2025	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	5.61%	4.9M	277.14M	0	0
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	5.84%	5.1M	288.51M	-1.76M	-25.69%
Sep 30, 2025	ROYAL BANK OF CANADA	0.29%	236.97K	13.41M	80.72K	+51.66%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.27%	238K	13.47M	-66.2K	-21.76%
Sep 30, 2025	GILDER GAGNON HOWE & CO LLC	0.28%	246.7K	13.96M	-82.32K	-25.02%
Sep 30, 2025	WOODLINE PARTNERS LP	0.28%	248K	14.04M	-250.11K	-50.21%
Sep 30, 2025	LOGOS GLOBAL MANAGEMENT LP	0.29%	250K	14.15M	250K	+100.00%
Sep 30, 2025	VANGUARD GROUP INC	6.21%	5.42M	306.87M	-198.13K	-3.53%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.02%	18.99K	1.07M	-7.71K	-28.87%
Sep 30, 2025	NEO IVY CAPITAL MANAGEMENT	0.02%	19.66K	1.11M	-839	-4.09%
Sep 30, 2025	HANDELSBANKEN FONDER AB	0.03%	21.7K	1.23M	5.2K	+31.52%
Sep 30, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.03%	22.53K	1.28M	-547	-2.37%
Sep 30, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.03%	23.13K	1.31M	18.13K	+362.68%
Sep 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.03%	23.56K	869K	0	0
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.03%	24.4K	1.38M	9.85K	+67.68%
Sep 30, 2025	ERSTE ASSET MANAGEMENT GMBH	0.03%	27K	1.58M	0	0
Sep 30, 2025	MOODY ALDRICH PARTNERS LLC	0.04%	28.91K	1.64M	-5.89K	-16.92%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	29.5K	1.67M	1.71K	+6.16%
Sep 30, 2025	HARBOR CAPITAL ADVISORS, INC.	0.04%	29.93K	1.69M	-3.54K	-10.59%
Sep 30, 2025	NAN FUNG GROUP HOLDINGS LTD	0.04%	30.88K	1.75M	0	0
Sep 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.04%	31.29K	1.77M	1.66K	+5.59%
Sep 30, 2025	FRANKLIN RESOURCES INC	0.04%	31.66K	1.79M	-1.99K	-5.91%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.04%	32.06K	1.81M	6.49K	+25.38%
Sep 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.05%	36.46K	2.06M	6.67K	+22.39%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.05%	43.5K	2.46M	1.97K	+4.75%
Sep 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.08%	61.64K	3.61M	-48.57K	-44.07%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.08%	68.3K	3.87M	28.16K	+70.15%
Sep 30, 2025	DEUTSCHE BANK AG\	0.09%	72.74K	4.12M	21.82K	+42.86%
Sep 30, 2025	RHUMBLINE ADVISERS	0.09%	74.17K	4.2M	3.12K	+4.38%
Sep 30, 2025	FIRST TRUST ADVISORS LP	0.09%	74.85K	4.24M	74.85K	+100.00%
Sep 30, 2025	INVESCO LTD.	0.1%	79.81K	4.52M	31.92K	+66.67%
Sep 30, 2025	ATIKA CAPITAL MANAGEMENT LLC	0.1%	81.3K	4.6M	-65.3K	-44.54%
Sep 30, 2025	SWISS NATIONAL BANK	0.1%	81.6K	4.62M	7.2K	+9.68%
Sep 30, 2025	ENSIGN PEAK ADVISORS, INC	0.11%	91.9K	5.2M	0	0
Sep 30, 2025	PATIENT SQUARE CAPITAL LP	0.12%	92.59K	5.24M	-47.41K	-33.86%
Sep 30, 2025	NUVEEN, LLC	0.13%	106.71K	6.04M	6.26K	+6.23%
Sep 30, 2025	MARSHALL WACE, LLP	0.41%	359.08K	20.32M	89.79K	+33.34%
Sep 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.13%	107.7K	6.1M	265	+0.25%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.19%	152.45K	8.63M	21.74K	+16.63%
Sep 30, 2025	BARCLAYS PLC	0.19%	155.14K	8.78M	11.96K	+8.36%
Sep 30, 2025	CANDRIAM S.C.A.	0.24%	191.64K	10.85M	37.54K	+24.36%
Sep 30, 2025	JPMORGAN CHASE & CO	0.24%	192.7K	10.91M	-15.02K	-7.23%
Sep 30, 2025	FMR LLC	6.73%	5.88M	332.79M	447.62K	+8.24%
Sep 30, 2025	TWO SIGMA ADVISERS, LP	0.43%	372.4K	21.08M	148.1K	+66.03%
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.49%	429.98K	24.34M	270.81K	+170.15%
Sep 30, 2025	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.5%	435.01K	24.62M	-52.95K	-10.85%
Sep 30, 2025	OCTAGON CAPITAL ADVISORS LP	0.41%	360K	20.38M	94K	+35.34%
Sep 30, 2025	MORGAN STANLEY	0.43%	377.8K	21.38M	140.19K	+59.00%
Sep 30, 2025	POLAR CAPITAL HOLDINGS PLC	0.45%	397.04K	22.47M	147.04K	+58.82%
Sep 30, 2025	UBS GROUP AG	0.74%	648.72K	36.72M	90.98K	+16.31%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.84%	731.42K	41.41M	168.06K	+29.83%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.26%	209.25K	11.84M	-25.72K	-10.95%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	5.95%	5.2M	294.08M	-176.37K	-3.28%
Sep 30, 2025	BVF INC/IL	6.3%	5.5M	311.45M	0	0
Sep 30, 2025	AVORO CAPITAL ADVISORS LLC	7.27%	6.35M	359.41M	-205.56K	-3.14%
Sep 30, 2025	BAKER BROS. ADVISORS LP	7.62%	6.65M	376.47M	0	0
Sep 30, 2025	GOLDMAN SACHS GROUP INC	0.81%	711.44K	40.27M	432.71K	+155.24%
Sep 30, 2025	COMMODORE CAPITAL LP	0.86%	750K	42.45M	0	0
Sep 30, 2025	MERCK & CO., INC.	0.88%	772.17K	43.7M	0	0
Sep 30, 2025	HOLOCENE ADVISORS, LP	0.96%	840.33K	47.56M	840.33K	+100.00%
Sep 30, 2025	BRAIDWELL LP	0.32%	276.69K	15.66M	276.69K	+100.00%
Sep 30, 2025	FIRST TURN MANAGEMENT, LLC	0.32%	277.73K	15.72M	277.73K	+100.00%
Sep 30, 2025	BOXER CAPITAL MANAGEMENT, LLC	0.37%	319.1K	18.06M	-112.91K	-26.14%
Sep 30, 2025	NORTHERN TRUST CORP	0.5%	437.12K	24.74M	27.77K	+6.78%
Sep 30, 2025	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	0.7%	611.22K	34.6M	520.59K	+574.43%
Sep 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.7%	615.09K	34.81M	565.09K	+1,130.18%
Jun 30, 2025	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	6.09%	4.9M	213.68M	0	0
Jun 30, 2025	UBS GROUP AG	0.69%	557.73K	24.34M	-35.87K	-6.04%
Jun 30, 2025	NEXTECH INVEST, LTD.	0.42%	340.91K	14.88B	340.91K	+100.00%
Jun 30, 2025	BOXER CAPITAL MANAGEMENT, LLC	0.54%	432.01K	18.85M	107.01K	+32.93%
Jun 30, 2025	MERCK & CO., INC.	0.96%	772.17K	33.7M	0	0
Jun 30, 2025	MORGAN STANLEY	0.3%	237.61K	10.37B	65.52K	+38.08%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.35%	278.74K	12.16B	-65.5K	-19.03%
Jun 30, 2025	CITADEL ADVISORS LLC	0.65%	518.89K	22.64B	516.38K	+20,614.05%
Jun 30, 2025	REDMILE GROUP, LLC	1%	803.29K	35.06M	-180.12K	-18.32%
Jun 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	1.02%	818.93K	35.74M	-77.48K	-8.64%
Jun 30, 2025	JENNISON ASSOCIATES LLC	1.03%	825.03K	36M	272.74K	+49.38%
Jun 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	1.16%	933.89K	40.75M	-234.9K	-20.10%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.48%	1.19M	52.08M	59.35K	+5.23%
Jun 30, 2025	STATE STREET CORP	1.93%	1.55M	67.84M	-206.28K	-11.72%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	6.68%	5.37M	234.44M	-624.81K	-10.42%
Jun 30, 2025	VANGUARD GROUP INC	6.99%	5.62M	245.25M	388.46K	+7.43%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	8.53%	6.86M	299.34M	156.75K	+2.34%
Jun 30, 2025	JPMORGAN CHASE & CO	0.26%	207.72K	9.06M	160.85K	+343.15%
Jun 30, 2025	POLAR CAPITAL HOLDINGS PLC	0.31%	250K	10.91M	250K	+100.00%
Jun 30, 2025	TD ASSET MANAGEMENT INC	0.29%	234.97K	10.25M	32.88K	+16.27%
Jun 30, 2025	ATIKA CAPITAL MANAGEMENT LLC	0.18%	146.6K	6.4M	146.6K	+100.00%
Jun 30, 2025	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.2%	162.32K	7.08M	18.09K	+12.54%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.53%	429.3K	18.73M	47.6K	+12.47%
Jun 30, 2025	FRONTIER CAPITAL MANAGEMENT CO LLC	0.61%	491.81K	21.46M	359.85K	+272.69%
Jun 30, 2025	AVORO CAPITAL ADVISORS LLC	8.15%	6.56M	286.08M	95.56K	+1.48%
Jun 30, 2025	MAVEN SECURITIES LTD	0.06%	50K	2.18M	50K	+100.00%
Jun 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.05%	40.14K	1.75M	-18.84K	-31.95%
Jun 30, 2025	SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)	0.05%	38.14K	1.66M	0	0
Jun 30, 2025	MOODY ALDRICH PARTNERS LLC	0.04%	34.8K	1.52M	34.8K	+100.00%
Jun 30, 2025	ROYCE & ASSOCIATES LP	0.04%	33.8K	1.47M	33.8K	+100.00%
Jun 30, 2025	HARBOR CAPITAL ADVISORS, INC.	0.04%	33.47K	1.46M	2.59K	+8.40%
Jun 30, 2025	STATE OF WISCONSIN INVESTMENT BOARD	0.04%	32.77K	1.43M	-24.45K	-42.73%
Jun 30, 2025	NAN FUNG GROUP HOLDINGS LTD	0.04%	30.88K	1.35M	0	0
Jun 30, 2025	HRT FINANCIAL LP	0.04%	28.91K	1.26M	28.91K	+100.00%
Jun 30, 2025	DARK FOREST CAPITAL MANAGEMENT LP	0.03%	25.95K	1.13M	-28.2K	-52.08%
Jun 30, 2025	BAKER BROS. ADVISORS LP	8.27%	6.65M	290.27M	655.5K	+10.93%
Jun 30, 2025	DEER MANAGEMENT CO. LLC	0.41%	325.9K	14.22M	-90K	-21.64%
Jun 30, 2025	ROYAL BANK OF CANADA	0.19%	156.25K	6.82M	154.11K	+7,187.92%
Jun 30, 2025	BVF INC/IL	6.84%	5.5M	240.14M	340.91K	+6.60%
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.07%	58.92K	2.57M	10.76K	+22.35%
Jun 30, 2025	WEISS ASSET MANAGEMENT LP	0.06%	50.79K	2.22M	50.79K	+100.00%
Jun 30, 2025	TREXQUANT INVESTMENT LP	0.06%	50.66K	2.21M	50.66K	+100.00%
Jun 30, 2025	FMR LLC	6.75%	5.43M	237.05M	1.02M	+23.20%
Jun 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	0.7%	562.99K	24.57M	37.85K	+7.21%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.7%	563.37K	24.59M	167.9K	+42.46%
Jun 30, 2025	BLACKROCK, INC.	5.16%	4.15M	181.03M	-134.64K	-3.14%
Jun 30, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.19%	152.17K	6.64M	9.58K	+6.72%
Jun 30, 2025	TWO SIGMA INVESTMENTS, LP	0.2%	159.16K	6.95M	11.54K	+7.82%
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.23%	184.48K	8.05M	184.48K	+100.00%
Jun 30, 2025	TWO SIGMA ADVISERS, LP	0.28%	224.3K	9.79M	41K	+22.37%
Jun 30, 2025	NORTHERN TRUST CORP	0.51%	409.35K	17.86M	-12.31K	-2.92%
Jun 30, 2025		0.42%	340.91K	14.88B	340.91K	+100.00%
Jun 30, 2025	MONASHEE INVESTMENT MANAGEMENT LLC	0.11%	85K	3.71M	85K	+100.00%
Jun 30, 2025	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	0.11%	90.63K	3.96M	90.63K	+100.00%
Jun 30, 2025	ENSIGN PEAK ADVISORS, INC	0.11%	91.9K	4.01M	91.9K	+100.00%
Jun 30, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.13%	101K	4.41M	71.5K	+242.35%
Jun 30, 2025	CHECKPOINT CAPITAL L.P.	0.13%	106.99K	4.67M	-29.61K	-21.68%
Jun 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.14%	110.21K	4.81M	-48.13K	-30.39%
Jun 30, 2025	YIHENG CAPITAL MANAGEMENT, L.P.	0.15%	122.61K	5.35M	0	0
Jun 30, 2025	PATIENT SQUARE CAPITAL LP	0.17%	140K	6.11M	-2.2K	-1.55%
Jun 30, 2025	FORESITE CAPITAL MANAGEMENT VI LLC	0.18%	146.33K	6.39M	0	0
Jun 30, 2025	CAPITAL RESEARCH GLOBAL INVESTORS	1.57%	1.26M	55.08M	896.99K	+245.62%
Jun 30, 2025	SIREN, L.L.C.	4.26%	3.43M	149.6M	187.84K	+5.80%
Jun 30, 2025	COMMODORE CAPITAL LP	0.93%	750K	32.73M	750K	+100.00%
Jun 30, 2025	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.61%	487.96K	21.29M	67.92K	+16.17%
Jun 30, 2025	AJU IB INVESTMENT CO., LTD.	0.57%	457.06K	19.95M	0	0
Jun 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.56%	450.37K	19.65M	-344.06K	-43.31%
Jun 30, 2025	GILDER GAGNON HOWE & CO LLC	0.41%	329.02K	14.36M	10.64K	+3.34%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.38%	304.2K	13.28M	304.2K	+100.00%
Jun 30, 2025	SUVRETTA CAPITAL MANAGEMENT, LLC	0.34%	275K	12M	275K	+100.00%
Jun 30, 2025	MARSHALL WACE, LLP	0.33%	269.28K	11.75M	67.38K	+33.37%
Jun 30, 2025	OCTAGON CAPITAL ADVISORS LP	0.33%	266K	11.61M	266K	+100.00%
Jun 30, 2025	PERCEPTIVE ADVISORS LLC	0.26%	210.11K	9.17M	210.11K	+100.00%
Jun 30, 2025	CANDRIAM S.C.A.	0.19%	154.1K	6.73M	154.1K	+100.00%
Jun 30, 2025	CAPTION MANAGEMENT, LLC	0.08%	64.8K	2.83M	29.6K	+84.09%
Jun 30, 2025	WOODLINE PARTNERS LP	0.62%	498.11K	21.74M	-27.13K	-5.17%
Jun 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.81%	653K	28.5M	60K	+10.12%
Mar 31, 2025	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.18%	144.22K	3.95M	-3.01K	-2.05%
Mar 31, 2025	BAKER BROS. ADVISORS LP	7.48%	6M	164.11M	0	0
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.48%	381.71K	10.45M	-5.48K	-1.42%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	7.48%	6M	164.13M	689.55K	+12.99%
Mar 31, 2025	AVORO CAPITAL ADVISORS LLC	8.06%	6.46M	176.81M	1.31M	+25.44%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.64%	510.48K	13.97M	394.56K	+340.38%
Mar 31, 2025	AJU IB INVESTMENT CO., LTD.	0.57%	457.06K	12.51M	0	0
Mar 31, 2025	NORTHERN TRUST CORP	0.53%	421.66K	11.54M	-16.17K	-3.69%
Mar 31, 2025	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.52%	420.05K	11.5M	555	+0.13%
Mar 31, 2025	DEER MANAGEMENT CO. LLC	0.52%	415.9K	11.38M	0	0
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.49%	395.47K	10.83M	-38.29K	-8.83%
Mar 31, 2025	GILDER GAGNON HOWE & CO LLC	0.4%	318.38K	8.71M	-7.97K	-2.44%
Mar 31, 2025	TD ASSET MANAGEMENT INC	0.25%	202.09K	5.53M	-26.47K	-11.58%
Mar 31, 2025	AQUILO CAPITAL MANAGEMENT, LLC	0.17%	138.52K	3.79M	-45K	-24.52%
Mar 31, 2025	MARSHALL WACE, LLP	0.25%	201.9K	5.53M	195.07K	+2,853.91%
Mar 31, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.74%	593K	16.23M	0	0
Mar 31, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.18%	142.59K	3.9M	-4.71K	-3.20%
Mar 31, 2025	SIREN, L.L.C.	4.04%	3.24M	88.69M	270.58K	+9.11%
Mar 31, 2025	STATE STREET CORP	2.2%	1.76M	48.19M	71.92K	+4.26%
Mar 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	1.46%	1.17M	31.99M	-221.58K	-15.94%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.41%	1.13M	31.04M	28.28K	+2.56%
Mar 31, 2025	REDMILE GROUP, LLC	1.23%	983.41K	26.92M	-117.02K	-10.63%
Mar 31, 2025	TWO SIGMA ADVISERS, LP	0.23%	183.3K	5.02M	-77K	-29.58%
Mar 31, 2025	IKARIAN CAPITAL, LLC	0.22%	176.8K	4.84M	176.8K	+100.00%
Mar 31, 2025	MORGAN STANLEY	0.21%	172.08K	4.71M	-67.68K	-28.23%
Mar 31, 2025	FORESITE CAPITAL MANAGEMENT VI LLC	0.18%	146.33K	4.01M	0	0
Mar 31, 2025		0.18%	143.24K	3.92M	143.24K	+100.00%
Mar 31, 2025	PATIENT SQUARE CAPITAL LP	0.18%	142.2K	3.89M	142.2K	+100.00%
Mar 31, 2025	CHECKPOINT CAPITAL L.P.	0.17%	136.61K	3.74M	59.07K	+76.18%
Mar 31, 2025	FRONTIER CAPITAL MANAGEMENT CO LLC	0.16%	131.96K	3.61M	-18.21K	-12.13%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.16%	126.88K	3.47M	-216	-0.17%
Mar 31, 2025	VANGUARD GROUP INC	6.53%	5.23M	143.18M	344.08K	+7.04%
Mar 31, 2025	BVF INC/IL	6.44%	5.16M	141.28M	0	0
Mar 31, 2025	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	6.11%	4.9M	134.02M	0	0
Mar 31, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.99%	794.44K	21.74M	-239.7K	-23.18%
Mar 31, 2025	MERCK & CO., INC.	0.96%	772.17K	21.13M	0	0
Mar 31, 2025	JENNISON ASSOCIATES LLC	0.69%	552.29K	15.12M	-164.65K	-22.97%
Mar 31, 2025	WOODLINE PARTNERS LP	0.66%	525.25K	14.38M	-12.18K	-2.27%
Mar 31, 2025	CAPITAL RESEARCH GLOBAL INVESTORS	0.46%	365.19K	10M	365.19K	+100.00%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.43%	344.24K	9.42M	-89.71K	-20.67%
Mar 31, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.2%	158.34K	4.69M	-5.56K	-3.39%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.18%	147.62K	4.04M	-26.13K	-15.04%
Mar 31, 2025	BLACKROCK, INC.	5.34%	4.28M	117.22M	-73.4K	-1.68%
Mar 31, 2025	FMR LLC	5.5%	4.41M	120.68M	-421.19K	-8.72%
Mar 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	1.12%	896.4K	24.53M	491.74K	+121.52%
Mar 31, 2025	EVENTIDE ASSET MANAGEMENT, LLC	0.66%	525.14K	14.37M	69.41K	+15.23%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	8.36%	6.7M	183.45M	-167.88K	-2.44%
Mar 31, 2025	JANUS HENDERSON GROUP PLC	0.96%	770.58K	22.81M	393.2K	+104.19%
Mar 31, 2025	UBS GROUP AG	0.74%	593.61K	16.25M	123.76K	+26.34%
Mar 31, 2024	GREAT LAKES ADVISORS, LLC	0.27%	156.38K	6.29M	156.38K	+100.00%
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.37%	218.8K	8.8M	32.32K	+17.33%
Mar 31, 2024	CITIGROUP INC	0.38%	220.91K	8.88M	131.98K	+148.41%
Mar 31, 2024	CREDIT SUISSE AG/	0.39%	227.59K	9.15M	63.43K	+38.64%
Mar 31, 2024	NORTHERN TRUST CORP	0.64%	372.79K	14.99M	14.21K	+3.96%
Mar 31, 2024	SCHONFELD STRATEGIC ADVISORS LLC	0.65%	380.44K	15.29M	-57.19K	-13.07%
Mar 31, 2024	AQUILO CAPITAL MANAGEMENT, LLC	0.67%	388.74K	15.63M	-492.59K	-55.89%
Mar 31, 2024	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.68%	395.14K	15.88M	-67.54K	-14.60%
Mar 31, 2024	DEER MANAGEMENT CO. LLC	0.71%	415.9K	16.72M	-200K	-32.47%
Mar 31, 2024	JENNISON ASSOCIATES LLC	0.73%	425.92K	17.12M	425.92K	+100.00%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.77%	450.52K	18.11M	-224.14K	-33.22%
Mar 31, 2024	JPMORGAN CHASE & CO	0.78%	455.94K	18.33M	-56.31K	-10.99%
Mar 31, 2024	WOODLINE PARTNERS LP	0.86%	500.93K	20.14M	400.18K	+397.20%
Mar 31, 2024	BVF INC/IL	8.84%	5.16M	207.5M	0	0
Mar 31, 2024	BAKER BROS. ADVISORS LP	10.27%	6M	241.04M	0	0
Mar 31, 2024	PRICE T ROWE ASSOCIATES INC /MD/	10.85%	6.33M	254.55M	996.3K	+18.67%
Mar 31, 2024	AXA S.A.	0.19%	109.22K	4.39M	109.22K	+100.00%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.2%	114.76K	4.61M	14.68K	+14.67%
Mar 31, 2024	SCHRODER INVESTMENT MANAGEMENT GROUP	0.21%	120.85K	4.86M	-64.45K	-34.78%
Mar 31, 2024	NEUBERGER BERMAN GROUP LLC	0.21%	125.18K	5.03M	4.1K	+3.39%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	1.65%	965.7K	38.83M	85.19K	+9.67%
Mar 31, 2024	DEEP TRACK CAPITAL, LP	2.16%	1.26M	50.74M	1.26M	+100.00%
Mar 31, 2024	ROCK SPRINGS CAPITAL MANAGEMENT LP	2.61%	1.52M	61.19M	0	0
Mar 31, 2024	REDMILE GROUP, LLC	2.97%	1.73M	69.71M	-89.87K	-4.93%
Mar 31, 2024	STATE STREET CORP	4.58%	2.67M	107.44M	778.24K	+41.08%
Mar 31, 2024	ARTAL GROUP S.A.	5.19%	3.03M	121.69M	496.4K	+19.61%
Mar 31, 2024	BLACKROCK INC.	6.26%	3.66M	146.96M	89.05K	+2.50%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.22%	127.75K	5.14M	-4.82K	-3.63%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.22%	130.89K	5.26M	-2.7K	-2.02%
Mar 31, 2024	GILDER GAGNON HOWE & CO LLC	0.23%	132.99K	5.35M	132.99K	+100.00%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.17%	102.1K	4.1M	63.7K	+165.89%
Mar 31, 2024	TREXQUANT INVESTMENT LP	0.28%	162.12K	6.52M	-41.45K	-20.36%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.28%	162.29K	6.52M	132.29K	+441.01%
Mar 31, 2024	UBS ASSET MANAGEMENT AMERICAS INC	0.31%	179.94K	7.23M	3.44K	+1.95%
Mar 31, 2024	TWO SIGMA ADVISERS, LP	0.36%	209.1K	8.41M	38.2K	+22.35%
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	0.36%	210.86K	8.48M	90.67K	+75.44%
Mar 31, 2024	CITADEL ADVISORS LLC	0.45%	261.38K	10.51M	-110.06K	-29.63%
Mar 31, 2024	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.46%	267.51K	10.75M	25.72K	+10.64%
Mar 31, 2024	UBS GROUP AG	0.51%	296.68K	11.93M	-3.78K	-1.26%
Mar 31, 2024	BARCLAYS PLC	0.55%	319.9K	12.86M	-61.88K	-16.21%
Mar 31, 2024	CANDRIAM S.C.A.	0.56%	328.3K	13.2M	-15K	-4.37%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	0.6%	349.21K	14.04M	-184.51K	-34.57%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.61%	354.11K	14.24M	47.41K	+15.46%
Mar 31, 2024	MORGAN STANLEY	0.94%	547.14K	22M	105.86K	+23.99%
Mar 31, 2024	MARSHALL WACE, LLP	0.98%	572.93K	23.03M	572.93K	+100.00%
Mar 31, 2024	AVORO CAPITAL ADVISORS LLC	6.66%	3.89M	156.33M	113.89K	+3.02%
Mar 31, 2024	WELLINGTON MANAGEMENT GROUP LLP	7.36%	4.29M	172.61M	-521.86K	-10.84%
Mar 31, 2024	VANGUARD GROUP INC	8.17%	4.77M	191.64M	769.49K	+19.25%
Mar 31, 2024	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	9.21%	5.38M	216.17M	-480.9K	-8.21%
Mar 31, 2024	INVESCO LTD.	0.19%	113.37K	4.56M	85.28K	+303.60%
Mar 31, 2024	FMR LLC	7.48%	4.36M	175.45M	3.83M	+716.39%
Mar 31, 2024	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	20.75K	834.31K	789	+3.95%
Mar 31, 2024	DEKABANK DEUTSCHE GIROZENTRALE	0.04%	23.56K	950K	1.56K	+7.10%
Mar 31, 2024	JEFFERIES FINANCIAL GROUP INC.	0.04%	24K	964.8K	0	0
Mar 31, 2024	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.04%	24.47K	787.49K	1.53K	+6.67%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.04%	25.63K	1.03M	25.63K	+100.00%
Mar 31, 2024	ALGERT GLOBAL LLC	0.05%	28.08K	1.13M	-71.29K	-71.74%
Mar 31, 2024	SIMPLIFY ASSET MANAGEMENT INC.	0.05%	30.52K	1.23M	0	0
Mar 31, 2024	PROFUND ADVISORS LLC	0.06%	32.83K	1.32B	12.94K	+65.06%
Mar 31, 2024	CAMPBELL & CO INVESTMENT ADVISER LLC	0.06%	34.7K	1.39M	3.6K	+11.57%
Mar 31, 2024	STATE OF WISCONSIN INVESTMENT BOARD	0.06%	37.85K	1.52M	8.25K	+27.87%
Mar 31, 2024	SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)	0.07%	38.14K	1.53M	38.14K	+100.00%
Mar 31, 2024	HARBOR CAPITAL ADVISORS, INC.	0.07%	41.33K	1.66M	6.69K	+19.32%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.07%	42.49K	1.71B	4.1K	+10.67%
Mar 31, 2024	CONGRESS ASSET MANAGEMENT CO /MA	0.08%	45.84K	1.84M	533	+1.18%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.08%	47.67K	1.92M	24.89K	+109.30%
Mar 31, 2024	PRUDENTIAL FINANCIAL INC	0.08%	49.4K	1.99M	49.4K	+100.00%
Mar 31, 2024	RUSSELL INVESTMENTS GROUP, LTD.	0.09%	51.76K	2.08M	2.65K	+5.39%
Mar 31, 2024	PROPEL BIO MANAGEMENT, LLC	0.1%	56.36K	2.27M	0	0
Mar 31, 2024	RHUMBLINE ADVISERS	0.1%	57.39K	2.31M	3.89K	+7.27%
Mar 31, 2024	FIRST TRUST ADVISORS LP	0.12%	67.74K	2.72M	67.74K	+100.00%
Mar 31, 2024	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.12%	71.49K	2.87M	71.49K	+100.00%
Mar 31, 2024	SWISS NATIONAL BANK	0.14%	79.7K	3.2M	8.7K	+12.25%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.16%	96K	3.86M	-40.83K	-29.84%
Mar 31, 2024	ATIKA CAPITAL MANAGEMENT LLC	0.17%	102K	4.1M	102K	+100.00%
Dec 31, 2023	CITIGROUP INC	0.15%	88.93K	2.26M	-11.87K	-11.77%
Dec 31, 2023	CUBIST SYSTEMATIC STRATEGIES, LLC	0.16%	95.58K	2.43M	95.58K	+100.00%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	0.17%	98.3K	2.5M	-73.62K	-42.82%
Dec 31, 2023	ALGERT GLOBAL LLC	0.17%	99.37K	2.53M	-29.16K	-22.69%
Dec 31, 2023	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.17%	100.07K	2.55M	23.09K	+30.00%
Dec 31, 2023	WOODLINE PARTNERS LP	0.17%	100.75K	2.57M	-2.44K	-2.36%
Dec 31, 2023	HRT FINANCIAL LP	0.18%	107.31K	2.73M	107.31K	+100.00%
Dec 31, 2023	RAFFERTY ASSET MANAGEMENT, LLC	0.21%	120.19K	3.06M	-29.91K	-19.93%
Dec 31, 2023	NEUBERGER BERMAN GROUP LLC	0.21%	121.08K	3.08M	121.08K	+100.00%
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	0.23%	132.56K	3.38M	-94.68K	-41.66%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.23%	133.59K	3.4M	7.33K	+5.80%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.23%	136.83K	3.48M	41.96K	+44.23%
Dec 31, 2023	CREDIT SUISSE AG/	0.28%	164.15K	4.18M	126.82K	+339.73%
Dec 31, 2023	TWO SIGMA ADVISERS, LP	0.29%	170.9K	4.35M	-17.6K	-9.34%
Dec 31, 2023	UBS ASSET MANAGEMENT AMERICAS INC	0.3%	176.5K	4.49M	-13.23K	-6.97%
Dec 31, 2023	SCHRODER INVESTMENT MANAGEMENT GROUP	0.32%	185.3K	4.72M	-42.28K	-18.58%
Dec 31, 2023	TD ASSET MANAGEMENT INC	0.32%	186.48K	4.75M	2.4K	+1.30%
Dec 31, 2023	JANE STREET GROUP, LLC	0.34%	195.97K	4.99M	96.92K	+97.84%
Dec 31, 2023	TREXQUANT INVESTMENT LP	0.35%	203.56K	5.18M	203.56K	+100.00%
Dec 31, 2023	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.41%	241.8K	6.16M	114.98K	+90.67%
Dec 31, 2023	UBS GROUP AG	0.51%	300.46K	7.65M	137.7K	+84.61%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.53%	306.69K	7.81M	4.95K	+1.64%
Dec 31, 2023	CANDRIAM S.C.A.	0.59%	343.3K	8.74M	-145K	-29.70%
Dec 31, 2023	NORTHERN TRUST CORP	0.61%	358.58K	9.13M	-7.68K	-2.10%
Dec 31, 2023	CITADEL ADVISORS LLC	0.64%	371.44K	9.46M	152.46K	+69.62%
Dec 31, 2023	BARCLAYS PLC	0.65%	381.78K	9.72M	-7.7K	-1.98%
Dec 31, 2023	SCHONFELD STRATEGIC ADVISORS LLC	0.75%	437.63K	11.14M	437.63K	+100.00%
Dec 31, 2023	MORGAN STANLEY	0.76%	441.28K	11.23M	101.95K	+30.04%
Dec 31, 2023	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.79%	462.68K	11.78M	-858	-0.19%
Dec 31, 2023	NORGES BANK	0.86%	504.08K	12.83M	504.08K	+100.00%
Dec 31, 2023	JPMORGAN CHASE & CO	0.88%	512.25K	13.04M	-109.75K	-17.64%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	0.91%	533.72K	13.59M	-121.5K	-18.54%
Dec 31, 2023	FMR LLC	0.92%	534.6K	13.61M	-335.95K	-38.59%
Dec 31, 2023	DEER MANAGEMENT CO. LLC	1.05%	615.9K	15.68M	0	0
Dec 31, 2023	GOLDMAN SACHS GROUP INC	1.15%	674.66K	17.18M	469.95K	+229.57%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.51%	880.52K	22.42M	46.29K	+5.55%
Dec 31, 2023	AQUILO CAPITAL MANAGEMENT, LLC	1.51%	881.34K	22.44M	99.12K	+12.67%
Dec 31, 2023	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	2.22%	1.3M	33M	-314.55K	-19.53%
Dec 31, 2023	ROCK SPRINGS CAPITAL MANAGEMENT LP	2.61%	1.52M	38.76M	17.89K	+1.19%
Dec 31, 2023	REDMILE GROUP, LLC	3.12%	1.82M	46.44M	-44.55K	-2.38%
Dec 31, 2023	STATE STREET CORP	3.24%	1.89M	48.23M	-91.61K	-4.61%
Dec 31, 2023	ARTAL GROUP S.A.	4.33%	2.53M	64.43M	725.39K	+40.18%
Dec 31, 2023	BLACKROCK INC.	6.1%	3.57M	90.81M	208.73K	+6.22%
Dec 31, 2023	AVORO CAPITAL ADVISORS LLC	6.46%	3.78M	96.11M	-80K	-2.08%
Dec 31, 2023	VANGUARD GROUP INC	6.84%	4M	101.78M	72.35K	+1.84%
Dec 31, 2023	WELLINGTON MANAGEMENT GROUP LLP	8.24%	4.82M	122.6M	4.82M	+100.00%
Dec 31, 2023	BVF INC/IL	8.84%	5.16M	131.42M	422.8K	+8.92%
Dec 31, 2023	PRICE T ROWE ASSOCIATES INC /MD/	9.13%	5.34M	135.85M	278.29K	+5.50%
Dec 31, 2023	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	10.03%	5.86M	149.15M	0	0
Dec 31, 2023	BAKER BROS. ADVISORS LP	10.26%	6M	152.66M	1.25M	+26.22%

Insiders

Among the KYMR insiders holding of 2.53% of the stake in company, ATLAS VENTURE FUND X, L.P., 10 percent owner, holds the largest shares of 828.83K. BAKER BROS. ADVISORS LP, , is the second largest KYMR insider with ownership of 701.33K shares. BOOTH BRUCE, director, stands third with possession of 685.39K shares of that stake.

Insiders	Designation	Shares Held
ATLAS VENTURE FUND X, L.P.	10 percent owner	828.83K
BAKER BROS. ADVISORS LP		701.33K
BOOTH BRUCE	director	685.39K
MAINOLFI NELLO	Chief Executive Officer	663.08K
BVF PARTNERS L P/IL	See Remarks and Footnotes	353.41K
JACOBS BRUCE N.	Chief Financial Officer	227.41K
GOLLOB JARED	Chief Medical Officer	109.99K
CHINIARA ELLEN	Chief Legal Officer	80.09K
CHADWICK JEREMY G	Chief Operating Officer	66.42K
CAUGHEY ELAINE	Chief Business Officer	18.99K
ALBERS JEFFREY W.	director	0
RIDLOFF ELENA	director	0
HOROBIN JOANNA	director	0
ESPOSITO PAMELA	director	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Dec 31, 2025	MAINOLFI NELLO	SALE	78.52	6.01K	472.21K	663.08K
Dec 17, 2025	ESPOSITO PAMELA	SALE	84.07	1K	84.07K	0
Dec 12, 2025	BOOTH BRUCE	SALE	91.04	108	9.83K	685.39K
Dec 11, 2025	BOOTH BRUCE	SALE	91.23	976	89.04K	685.5K
Dec 11, 2025	BAKER BROS. ADVISORS LP	PURCHASE	86.00	167.19K	14.38M	701.33K
Dec 10, 2025	BOOTH BRUCE	SALE	93.20	16.34K	1.52M	686.48K
Dec 08, 2025	GOLLOB JARED	SALE	92.19	1.4K	129.07K	109.99K
Dec 08, 2025	ALBERS JEFFREY W.	SALE	90.30	2.25K	203.36K	0
Dec 08, 2025	MAINOLFI NELLO	SALE	89.17	100K	8.92M	660.48K
Oct 29, 2025	MAINOLFI NELLO	SALE	61.46	3.63K	222.91K	660.48K
Oct 15, 2025	GOLLOB JARED	SALE	63.09	6.45K	407.1K	109.99K
Oct 13, 2025	ALBERS JEFFREY W.	SALE	59.19	5K	295.95K	0
Oct 13, 2025	GOLLOB JARED	SALE	60.00	3.11K	186.84K	118.36K
Sep 17, 2025	JACOBS BRUCE N.	SALE	50.00	79.22K	3.96M	227.41K
Sep 16, 2025	MAINOLFI NELLO	SALE	49.00	30K	1.47M	660.48K
Jun 30, 2025	BAKER BROS. ADVISORS LP	PURCHASE	44.00	55.19K	2.43M	534.13K
Jun 30, 2025	BVF PARTNERS L P/IL	PURCHASE	44.00	58.78K	2.59M	353.41K
Jun 11, 2025	RIDLOFF ELENA	SALE	50.00	4.5K	225K	0
Jun 03, 2025	RIDLOFF ELENA	SALE	47.00	4.8K	225.6K	0
Jun 03, 2025	ESPOSITO PAMELA	SALE	49.04	5K	245.19K	0
Jun 03, 2025	MAINOLFI NELLO	SALE	49.00	30K	1.47M	660.48K
Jun 03, 2025	ALBERS JEFFREY W.	SALE	49.00	6.35K	311.1K	0
May 23, 2025	CHADWICK JEREMY G	SALE	29.30	2.58K	75.44K	66.42K
Mar 03, 2025	CHINIARA ELLEN	SALE	31.00	408	12.65K	80.09K
Mar 03, 2025	GOLLOB JARED	SALE	31.00	1.05K	32.4K	120K
Mar 03, 2025	JACOBS BRUCE N.	SALE	31.00	1.28K	39.72K	201.89K
Mar 03, 2025	CHADWICK JEREMY G	SALE	31.00	252	7.81K	67.8K
Jan 06, 2025	CHINIARA ELLEN	SALE	41.75	3.13K	130.64K	54.83K
Dec 02, 2024	ESPOSITO PAMELA	SALE	49.00	2.5K	122.5K	0
Sep 17, 2024	ESPOSITO PAMELA	SALE	48.75	7.15K	348.58K	0
Aug 26, 2024	ALBERS JEFFREY W.	SALE	49.10	5K	245.51K	0
Aug 21, 2024	BAKER BROS. ADVISORS LP	PURCHASE	0.00	347.57K	34.76	919K
Aug 20, 2024	BAKER BROS. ADVISORS LP	PURCHASE	46.41	1	46.41	5.52M
Aug 20, 2024	BVF PARTNERS L P/IL	PURCHASE	0.00	156.74K	15.67	156.74K
Jul 16, 2024	GOLLOB JARED	SALE	46.10	9.86K	454.7K	95.47K
Jul 15, 2024	GOLLOB JARED	SALE	45.15	16.46K	742.93K	95.74K
Jul 09, 2024	BOOTH BRUCE	SALE	39.26	20.24K	794.54K	723.25K
Jun 13, 2024	BOOTH BRUCE	SALE	34.98	1.77K	61.91K	802.02K
Jun 12, 2024	BOOTH BRUCE	SALE	36.02	420	15.13K	803.79K
Jun 07, 2024	HOROBIN JOANNA	SALE	33.11	6.31K	209.01K	0
May 23, 2024	CHADWICK JEREMY G	SALE	34.99	2.58K	90.1K	44.18K
Mar 15, 2024	BOOTH BRUCE	SALE	41.23	329	13.56K	806.7K
Mar 14, 2024	BOOTH BRUCE	SALE	41.51	154	6.39K	819.15K
Mar 13, 2024	BOOTH BRUCE	SALE	42.84	1.39K	59.38K	828.83K
Mar 13, 2024	ATLAS VENTURE FUND X, L.P.	SALE	42.84	1.39K	59.38K	828.83K
Mar 12, 2024	ATLAS VENTURE FUND X, L.P.	SALE	42.52	1.82K	77.34K	853K
Mar 12, 2024	BOOTH BRUCE	SALE	42.52	1.82K	77.34K	853K
Mar 11, 2024	BOOTH BRUCE	SALE	43.42	1.05K	45.37K	881.27K
Mar 11, 2024	ATLAS VENTURE FUND X, L.P.	SALE	43.42	1.05K	45.37K	881.27K
Mar 04, 2024	GOLLOB JARED	SALE	43.26	216	9.34K	95.74K
Mar 04, 2024	JACOBS BRUCE N.	SALE	43.26	255	11.03K	142.35K
Feb 27, 2024	GOLLOB JARED	SALE	45.00	400	18K	74.71K
Feb 21, 2024	ALBERS JEFFREY W.	SALE	39.05	4.39K	171.23K	0
Feb 20, 2024	ALBERS JEFFREY W.	SALE	39.07	615	24.03K	0
Feb 09, 2024	GOLLOB JARED	SALE	36.09	7.4K	267.01K	74.71K
Jan 23, 2024	ALBERS JEFFREY W.	SALE	30.05	10K	300.47K	0
Jan 05, 2024	BVF PARTNERS L P/IL	PURCHASE	0.00	52.73K	5.27	52.73K
Jan 04, 2024	CHINIARA ELLEN	SALE	22.58	3.3K	74.42K	34.21K
Nov 03, 2023	BVF PARTNERS L P/IL	PURCHASE	14.07	10.11K	142.18K	294.63K
Nov 02, 2023	BVF PARTNERS L P/IL	PURCHASE	11.64	26.77K	311.74K	284.53K
Mar 02, 2023	CAUGHEY ELAINE	SALE	31.40	164	5.15K	18.99K
Mar 02, 2023	JACOBS BRUCE N.	SALE	31.40	314	9.86K	104.57K
Mar 02, 2023	GOLLOB JARED	SALE	31.40	297	9.32K	74.71K
Jan 12, 2023	BVF PARTNERS L P/IL	PURCHASE	31.24	15.91K	497.13K	1.89M
Jan 12, 2023	ATLAS VENTURE FUND X, L.P.	SALE	30.29	21.59K	654.02K	890.15K
Jan 12, 2023	BOOTH BRUCE	SALE	30.29	21.59K	654.02K	890.15K
Jan 11, 2023	ATLAS VENTURE FUND X, L.P.	SALE	29.96	6.07K	181.89K	911.74K
Jan 11, 2023	BVF PARTNERS L P/IL	PURCHASE	29.89	11.15K	333.21K	1.87M
Jan 11, 2023	BOOTH BRUCE	SALE	29.96	6.07K	181.89K	911.74K
Dec 15, 2022	ATLAS VENTURE FUND X, L.P.	SALE	30.00	717	21.51K	917.81K
Dec 15, 2022	BOOTH BRUCE	SALE	30.00	717	21.51K	917.81K
Dec 14, 2022	BOOTH BRUCE	SALE	31.44	101.19K	3.18M	5.15M
Dec 14, 2022	ATLAS VENTURE FUND X, L.P.	SALE	32.33	54.74K	1.77M	5.1M

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE167.19K1

SALES255.5K14

NET SHARES-88.31K13

SHARES HELD5.97M15

% NET SHARES-101.48%-13.33%

Frequently Asked Questions