How many institutions own JANX stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own JANX shares is 255, representing 109.99% of the company's common stock.

Who are the major shareholders selling Janux Therapeutics, Inc. stock?

SCHRODER INVESTMENT MANAGEMENT GROUP, in the last quarter, reduced its stake in JANX by -10.65% restricting it's holding to 267.05 thousand shares of worth nearly $3.69M. PICTET ASSET MANAGEMENT HOLDING SA also lessened -54.23% of the JANX shares from its portfolio, reducing its holding to 272.25 thousand shares of worth $3.76M. JPMORGAN CHASE & CO also shunned JANX shares holding by -18.49% last quarter which brought its holding to 170.51 thousand shares worth $2.35M.

Investors who are buying JANX stock?

As per its latest 13F filing, MACQUARIE MANAGEMENT HOLDINGS, INC. increased its stake in JANX by 100% in the last quarter. The institutional holder raised its holding to 76.6 thousand shares having worth more than $1.06B. WALLEYE CAPITAL LLC also added 801.75% more shares of JANX to its portfolio, raising its holding to 323.02 thousand shares of worth $4.46M. UNIVERSITY OF WISCONSIN FOUNDATION also increased its JANX shares holding by 100% which brought its holding to 362 thousand shares worth $5.00M.

JANX's major insiders: who are they?

The insider with the most stakes in JANX is RA CAPITAL MANAGEMENT, L.P. , at the company. Additionally, JANX stock is highly held by 10 percent owner Bregua Corp and Acting Chief Financial Officer Reardon Tighe among others.

Did an insider recently sell JANX stock?

Company executives, directors, and other insiders own 6.59% percent of Janux Therapeutics, Inc.'s stock. Within the last six months, there have been 9 transaction(s) in which JANX insiders have sold stock, totaling 39.66K shares. Insiders that have sold shares include DOBEK MARIA, MEYER ANDREW HOLLMAN, and DIRAIMONDO THOMAS.

Which insider recently purchased JANX stock?

There have been 0 transaction(s) during the past 6-months in which Janux Therapeutics, Inc. insiders have bought stock, totalling 0 shares

How much of JANX does insiders own?

Around 860.97K Janux Therapeutics, Inc. shares are held by insiders, which represents about 6.59% of JANX stock.

Who is the insider with the largest stake?

JANX , RA CAPITAL MANAGEMENT, L.P. holds the largest portfolio of the company's shares. JANX shares owned by RA total nearly 10.14 million.

Which institution holds the most shares in JANX?

MACQUARIE MANAGEMENT HOLDINGS, INC. is the largest institutional owner in JANX which holds 76.6 thousand shares worth $1.06B or 0.12% of the total JANX shares outstanding followed by SCHRODER INVESTMENT MANAGEMENT GROUP with ownership of 267.05 thousand shares representing 0.43% of the JANX ownership. PICTET ASSET MANAGEMENT HOLDING SA is the third largest stakeholder with 272.25 thousand shares or 0.44% of the ownership worth more than $3.76M.

Is Janux Therapeutics, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the JANX is concerned, it is a stock which is optionable.

Is there a short position on JANX's shares?

Number of JANX shares short is 8.73M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding JANX shares are there?

As of today, 60.09M shares of JANX are outstanding.

Is there many float in JANX stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, JANX has 44.97M shares in float.

JANX short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for JANX is 10.83.

Janux Therapeutics (JANX) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares14.73

Short Percent Of Float21.29

Shares Outstanding60.09M

Shares Float44.97M

Shares Short8.73M

Short Ratio10.83

21.29%

Short % of Float

14.73%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

6.59% Percentage of Shares held by All Insiders

109.99% Percentage of Shares held by All Institutions

117.75% Percentage of Float held by Institutions

255

Number of Institutions Holding Shares

Institutional Ownership

About 109.99% of JANX shares are held by financial institutions. MACQUARIE MANAGEMENT HOLDINGS, INC. is the top corporate investor, holding 76.6K shares valued at $1.06B. A 0.12% stake in Janux Therapeutics, Inc. is owned by the company. SCHRODER INVESTMENT MANAGEMENT GROUP owns 267.05K shares valued at $3.69M, which translates its holding of 0.43% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	MACQUARIE MANAGEMENT HOLDINGS, INC.	0.12%	76.6K	1.06B	76.6K	+100.00%
Dec 31, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.43%	267.05K	3.69M	-31.83K	-10.65%
Dec 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.44%	272.25K	3.76M	-322.58K	-54.23%
Dec 31, 2025	WALLEYE CAPITAL LLC	0.52%	323.02K	4.46M	287.2K	+801.75%
Dec 31, 2025	UNIVERSITY OF WISCONSIN FOUNDATION	0.58%	362K	5M	362K	+100.00%
Dec 31, 2025	SQUAREPOINT OPS LLC	0.63%	390.95K	5.4M	324.79K	+490.91%
Dec 31, 2025	JPMORGAN CHASE & CO	0.27%	170.51K	2.35M	-38.67K	-18.49%
Dec 31, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.28%	175.25K	2.42M	99.05K	+130.00%
Dec 31, 2025	SWISS NATIONAL BANK	0.12%	77.1K	1.06M	2.5K	+3.35%
Dec 31, 2025	TUDOR INVESTMENT CORP ET AL	0.13%	79.16K	1.09M	-19.4K	-19.68%
Dec 31, 2025	SG AMERICAS SECURITIES, LLC	0.13%	79.82K	1.1M	50.8K	+175.09%
Dec 31, 2025	DEEP TRACK CAPITAL, LP	0.14%	89.59K	1.24M	89.59K	+100.00%
Dec 31, 2025	NUVEEN, LLC	0.16%	96.42K	1.33M	787	+0.82%
Dec 31, 2025	JUMP FINANCIAL, LLC	0.16%	96.68K	1.33M	-83.02K	-46.20%
Dec 31, 2025	BLUE OWL CAPITAL HOLDINGS LP	0.16%	100K	1.38M	100K	+100.00%
Dec 31, 2025	TWO SIGMA ADVISERS, LP	0.17%	104.1K	1.44M	104.1K	+100.00%
Dec 31, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.18%	110K	1.52M	60K	+120.00%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.2%	122.07K	1.68M	1.59K	+1.32%
Dec 31, 2025	XTX TOPCO LTD	0.26%	161.43K	2.23M	161.43K	+100.00%
Dec 31, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.36%	225.38K	3.11M	125.25K	+125.09%
Dec 31, 2025	ALGERT GLOBAL LLC	0.3%	183.37K	2.53M	95.15K	+107.86%
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.34%	212.5K	2.93M	164.9K	+346.43%
Dec 31, 2025	JANUS HENDERSON GROUP PLC	8.63%	5.35M	73.85M	649.34K	+13.81%
Dec 31, 2025	RA CAPITAL MANAGEMENT, L.P.	18.04%	11.19M	154.42M	0	0
Dec 31, 2025	RHUMBLINE ADVISERS	0.08%	52.36K	722.57M	-5.28K	-9.16%
Dec 31, 2025	HEADLANDS TECHNOLOGIES LLC	0.09%	56.5K	779.66K	56.5K	+100.00%
Dec 31, 2025	CONGRESS ASSET MANAGEMENT CO /MA	0.09%	57.34K	791.32K	1.57K	+2.81%
Dec 31, 2025	JANE STREET GROUP, LLC	0.87%	540.23K	7.46M	458.91K	+564.31%
Dec 31, 2025	HRT FINANCIAL LP	0.1%	63.54K	876K	63.54K	+100.00%
Dec 31, 2025	PROFUND ADVISORS LLC	0.1%	64.02K	883.5K	47.58K	+289.48%
Dec 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.12%	75.5K	1.04M	9.17K	+13.83%
Dec 31, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.08%	49.5K	2.04M	0	0
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	0.47%	289.81K	4M	189.16K	+187.95%
Dec 31, 2025	TWO SIGMA INVESTMENTS, LP	0.76%	471.01K	6.5M	367.53K	+355.19%
Dec 31, 2025	UBS GROUP AG	0.95%	590.06K	8.14M	199.7K	+51.16%
Dec 31, 2025	MORGAN STANLEY	1%	618.39K	8.53M	122.75K	+24.77%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	1.19%	738.33K	10.19M	244.88K	+49.63%
Dec 31, 2025	LOGOS GLOBAL MANAGEMENT LP	1.61%	1M	13.8M	65K	+6.95%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	1.73%	1.07M	14.82M	418.55K	+63.89%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.8%	1.11M	15.37M	29.72K	+2.74%
Dec 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	2.1%	1.3M	17.96M	876.24K	+206.25%
Dec 31, 2025	PROSIGHT MANAGEMENT, LP	3.86%	2.39M	33.02M	1.53M	+176.48%
Dec 31, 2025	LESTER MURRAY ANTMAN DBA SIMPLYRICH	0.04%	24.32K	335K	0	0
Dec 31, 2025	DLD ASSET MANAGEMENT, LP	0.04%	25K	345.13K	25K	+100.00%
Dec 31, 2025	AMERICAN CENTURY COMPANIES INC	0.04%	27.69K	382.14K	8.74K	+46.10%
Dec 31, 2025	WINTON GROUP LTD	0.05%	31.8K	438.84K	31.8K	+100.00%
Dec 31, 2025	FRANKLIN RESOURCES INC	0.62%	385.3K	5.32M	-502.45K	-56.60%
Dec 31, 2025	VANGUARD GROUP INC	4.69%	2.91M	40.11M	489.28K	+20.24%
Dec 31, 2025	STATE STREET CORP	6.21%	3.85M	53.18M	1.96M	+103.75%
Dec 31, 2025	BLACKROCK, INC.	6.58%	4.08M	56.31M	349.21K	+9.36%
Dec 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.35%	216.01K	2.98M	105.16K	+94.86%
Dec 31, 2025	BARCLAYS PLC	0.36%	221.23K	3.05M	77.21K	+53.61%
Dec 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.36%	224.29K	3.1M	-16.34K	-6.79%
Dec 31, 2025	CAPTION MANAGEMENT, LLC	0.44%	272.5K	3.76M	182.5K	+202.78%
Dec 31, 2025	NORTHERN TRUST CORP	0.55%	340.41K	4.7M	-13.71K	-3.87%
Dec 31, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.58%	358.8K	4.95M	148.43K	+70.56%
Dec 31, 2025	NATIONALE-NEDERLANDEN POWSZECHNE TOWARZYSTWO EMERYTALNE S.A.	0.61%	376.5K	5.2M	0	0
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.63%	390.51K	5.39M	35.96K	+10.14%
Dec 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.4%	245.45K	3.39M	-105.58K	-30.08%
Dec 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.64%	400K	5.52M	-2.38M	-85.59%
Dec 31, 2025	CORMORANT ASSET MANAGEMENT, LP	1.05%	650K	8.97M	-200K	-23.53%
Dec 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	1.2%	744.47K	10.27M	-521.09K	-41.17%
Dec 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	1.43%	885.55K	12.22M	885.55K	+100.00%
Dec 31, 2025	READYSTATE ASSET MANAGEMENT LP	1.43%	885.9K	12.23M	-74.48K	-7.76%
Dec 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	1.55%	961.82K	13.27M	-748.38K	-43.76%
Dec 31, 2025	WOODLINE PARTNERS LP	1.66%	1.03M	14.18M	283	+0.03%
Dec 31, 2025	CITADEL ADVISORS LLC	1.78%	1.1M	15.24M	301.36K	+37.54%
Dec 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	2.6%	1.61M	22.22M	908.58K	+129.50%
Dec 31, 2025	TCG CROSSOVER MANAGEMENT, LLC	2.89%	1.79M	24.7M	1.79M	+100.00%
Dec 31, 2025	ORBIMED ADVISORS LLC	3.15%	1.95M	26.97M	188.33K	+10.66%
Dec 31, 2025	FMR LLC	5.66%	3.51M	48.47M	-5.54M	-61.22%
Dec 31, 2025	DEUTSCHE BANK AG\	0.05%	32.17K	443.95K	-3.99K	-11.03%
Dec 31, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.06%	36.56K	504.95K	-28.43K	-43.75%
Dec 31, 2025	TEMA ETFS LLC	0.06%	37.09K	511.87K	-3.26K	-8.08%
Dec 31, 2025	TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY	0.06%	38.88K	536K	38.88K	+100.00%
Dec 31, 2025	LEGAL & GENERAL GROUP PLC	0.07%	43.47K	599.84K	5.55K	+14.64%
Dec 31, 2025	RAIFFEISEN BANK INTERNATIONAL AG	0.07%	46K	636.18K	22K	+91.67%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.08%	47.92K	661.28K	19.4K	+68.03%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.02%	11.75K	287.07K	0	0
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.02%	13.88K	339.11K	6.2K	+80.83%
Sep 30, 2025	HANDELSBANKEN FONDER AB	0.02%	14K	342K	0	0
Sep 30, 2025	GSA CAPITAL PARTNERS LLP	0.03%	15.46K	378K	15.46K	+100.00%
Sep 30, 2025	PROFUND ADVISORS LLC	0.03%	16.44K	401.75K	6.39K	+63.53%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	16.74K	409.2K	-5.19K	-23.67%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.03%	17.5K	427.77K	-38.03K	-68.49%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.03%	18.95K	463.21K	7.66K	+67.87%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	23.88K	583.53K	0	0
Sep 30, 2025	RAIFFEISEN BANK INTERNATIONAL AG	0.04%	24K	568.8K	24K	+100.00%
Sep 30, 2025	FOX RUN MANAGEMENT, L.L.C.	0.04%	24.29K	593.75K	24.29K	+100.00%
Sep 30, 2025	LESTER MURRAY ANTMAN DBA SIMPLYRICH	0.04%	24.32K	594K	0	0
Sep 30, 2025	INVESCO LTD.	0.04%	24.47K	598.02K	6.17K	+33.72%
Sep 30, 2025	QUADRATURE CAPITAL LTD	0.04%	26.86K	656.48K	26.86K	+100.00%
Sep 30, 2025	ERSTE ASSET MANAGEMENT GMBH	0.04%	27K	639.9K	0	0
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.05%	28.52K	696.98K	4.84K	+20.42%
Sep 30, 2025	FIRST TURN MANAGEMENT, LLC	1.03%	639.7K	15.63M	192.28K	+42.98%
Sep 30, 2025	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	1.57%	972.69K	23.77M	972.69K	+100.00%
Sep 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	4.72%	2.92M	71.37M	0	0
Sep 30, 2025	SG AMERICAS SECURITIES, LLC	0.05%	29.02K	709K	20.67K	+247.82%
Sep 30, 2025	DEUTSCHE BANK AG\	0.06%	36.16K	883.7K	6.14K	+20.45%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.06%	37.92K	926.67K	-9.44K	-19.93%
Sep 30, 2025	TEMA ETFS LLC	0.07%	40.35K	986.18K	-9.71K	-19.40%
Sep 30, 2025	NEOS INVESTMENT MANAGEMENT LLC	0.07%	40.35K	986.18K	-9.71K	-19.40%
Sep 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.08%	49.5K	2.02M	0	0
Sep 30, 2025	HEALTHINVEST PARTNERS AB	0.08%	49.82K	129.27K	0	0
Sep 30, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.08%	50K	1.22M	20K	+66.67%
Sep 30, 2025	AVALON VENTURES MANAGEMENT, LLC	0.09%	53.3K	1.3M	10K	+23.09%
Sep 30, 2025	CONGRESS ASSET MANAGEMENT CO /MA	0.09%	55.77K	1.36M	55.77K	+100.00%
Sep 30, 2025	RHUMBLINE ADVISERS	0.09%	57.64K	1.41M	-1.75K	-2.94%
Sep 30, 2025	ORBIMED ADVISORS LLC	2.85%	1.77M	43.16M	555.8K	+45.92%
Sep 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	2.76%	1.71M	41.8M	-433.7K	-20.23%
Sep 30, 2025	QUINN OPPORTUNITY PARTNERS LLC	0.1%	59.89K	1.46M	0	0
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.8%	493.45K	12.06M	-365.97K	-42.58%
Sep 30, 2025	LOGOS GLOBAL MANAGEMENT LP	0.81%	500K	12.22M	0	0
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.06%	655.11K	16.01M	306.62K	+87.98%
Sep 30, 2025	TANG CAPITAL MANAGEMENT LLC	1.13%	700K	17.11M	500K	+250.00%
Sep 30, 2025	SWISS NATIONAL BANK	0.12%	74.6K	1.82M	-4.5K	-5.69%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.12%	76.2K	1.86M	29.27K	+62.36%
Sep 30, 2025	MACQUARIE GROUP LTD	0.12%	76.6K	1.87M	0	0
Sep 30, 2025	BIOIMPACT CAPITAL LLC	0.99%	614.28K	15.01M	0	0
Sep 30, 2025	CITADEL ADVISORS LLC	1.3%	802.78K	19.62M	-428.34K	-34.79%
Sep 30, 2025	CORMORANT ASSET MANAGEMENT, LP	1.37%	850K	20.77M	-650K	-43.33%
Sep 30, 2025	STATE STREET CORP	3.06%	1.89M	46.23M	503.36K	+36.26%
Sep 30, 2025	FMR LLC	14.63%	9.06M	221.33M	167.32K	+1.88%
Sep 30, 2025	VANGUARD GROUP INC	3.9%	2.42M	59.07M	227.68K	+10.40%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	4.48%	2.78M	67.82M	250K	+9.90%
Sep 30, 2025	UBS GROUP AG	0.63%	390.36K	9.54M	97.82K	+33.44%
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.17%	103.48K	2.53M	-906	-0.87%
Sep 30, 2025	JPMORGAN CHASE & CO	0.34%	209.18K	5.11M	-38.24K	-15.46%
Sep 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.34%	210.37K	5.14M	100	+0.05%
Sep 30, 2025	AMERIPRISE FINANCIAL INC	0.41%	256.06K	6.26M	470	+0.18%
Sep 30, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0.42%	257.53K	6.29M	115.75K	+81.64%
Sep 30, 2025	PERCEPTIVE ADVISORS LLC	0.47%	292.69K	7.15M	0	0
Sep 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.48%	298.88K	7.08M	51.96K	+21.04%
Sep 30, 2025	BLACKROCK, INC.	6.03%	3.73M	91.19M	328.15K	+9.64%
Sep 30, 2025	ROYAL BANK OF CANADA	0.54%	331.58K	8.1M	-2.18K	-0.65%
Sep 30, 2025	ABRDN PLC	0.56%	345.48K	8.44M	60.19K	+21.10%
Sep 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.57%	351.03K	8.58M	288.94K	+465.38%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.57%	354.54K	8.67M	55.17K	+18.43%
Sep 30, 2025	NATIONALE-NEDERLANDEN POWSZECHNE TOWARZYSTWO EMERYTALNE S.A.	0.61%	376.5K	9.2M	0	0
Sep 30, 2025	JANUS HENDERSON GROUP PLC	7.59%	4.7M	114.99M	240.78K	+5.40%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.27%	167.1K	4.08M	64.8K	+63.34%
Sep 30, 2025	JUMP FINANCIAL, LLC	0.29%	179.7K	4.39M	-48.73K	-21.33%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.39%	240.63K	5.88M	101.97K	+73.54%
Sep 30, 2025	NORTHERN TRUST CORP	0.57%	354.11K	8.65M	12.27K	+3.59%
Sep 30, 2025	MORGAN STANLEY	0.8%	495.64K	12.11M	179.9K	+56.98%
Sep 30, 2025	ALGERT GLOBAL LLC	0.14%	88.22K	2.16M	-4.27K	-4.61%
Sep 30, 2025	CAPTION MANAGEMENT, LLC	0.15%	90K	2.2M	-367.01K	-80.31%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.15%	92.3K	2.26M	27.07K	+41.49%
Sep 30, 2025	NUVEEN, LLC	0.15%	95.63K	2.34M	-346	-0.36%
Sep 30, 2025	TUDOR INVESTMENT CORP ET AL	0.16%	98.56K	2.41M	-15.19K	-13.36%
Sep 30, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.16%	100.13K	2.45M	45K	+81.63%
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	18.08%	11.19M	273.48M	0	0
Sep 30, 2025	PROSIGHT MANAGEMENT, LP	1.4%	865.35K	21.15M	11.45K	+1.34%
Sep 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.96%	594.83K	14.54M	-76.65K	-11.42%
Sep 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.18%	110.85K	2.71M	-137.02K	-55.28%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.19%	120.47K	2.94M	5.77K	+5.03%
Sep 30, 2025	BARCLAYS PLC	0.23%	144.02K	3.52M	11.68K	+8.83%
Sep 30, 2025	WOODLINE PARTNERS LP	1.66%	1.03M	25.1M	-215K	-17.31%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.75%	1.08M	26.49M	181.55K	+20.12%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.04%	1.27M	30.93M	-527.87K	-29.43%
Sep 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.69%	424.85K	10.38M	166.17K	+64.24%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	1.13%	701.6K	17.15M	209.24K	+42.50%
Sep 30, 2025	FRANKLIN RESOURCES INC	1.43%	887.76K	21.7M	-181.44K	-16.97%
Sep 30, 2025	READYSTATE ASSET MANAGEMENT LP	1.55%	960.38K	23.47M	264.42K	+37.99%
Jun 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.42%	258.68K	5.98M	-150K	-36.70%
Jun 30, 2025	PERCEPTIVE ADVISORS LLC	0.47%	292.69K	6.76M	-677.73K	-69.84%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.35%	214.36K	4.95M	132.09K	+160.55%
Jun 30, 2025	VANGUARD GROUP INC	3.54%	2.19M	50.58M	-89.23K	-3.92%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.9%	1.79M	41.43M	400.6K	+28.76%
Jun 30, 2025	FRANKLIN RESOURCES INC	1.73%	1.07M	24.7M	-117.28K	-9.89%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.46%	902.31K	20.85M	121.4K	+15.55%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	1.39%	859.42K	19.85M	110.1K	+14.69%
Jun 30, 2025	BIOIMPACT CAPITAL LLC	0.99%	614.28K	14.19M	47.09K	+8.30%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.8%	492.36K	11.37M	98.88K	+25.13%
Jun 30, 2025	CAPTION MANAGEMENT, LLC	0.74%	457.01K	10.56M	412.57K	+928.31%
Jun 30, 2025	ROYAL BANK OF CANADA	0.54%	333.75K	7.71M	332K	+18,906.38%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.48%	299.38K	6.92M	25.73K	+9.40%
Jun 30, 2025	UBS GROUP AG	0.47%	292.53K	6.76M	-195.95K	-40.11%
Jun 30, 2025	ABRDN PLC	0.46%	285.29K	6.59M	60.5K	+26.91%
Jun 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.43%	264.9K	6.12M	0	0
Jun 30, 2025	JPMORGAN CHASE & CO	0.4%	247.42K	5.72M	112.12K	+82.86%
Jun 30, 2025	IKARIAN CAPITAL, LLC	0.21%	129.69K	3M	0	0
Jun 30, 2025	TUDOR INVESTMENT CORP ET AL	0.18%	113.75K	2.63M	-60.6K	-34.76%
Jun 30, 2025	LAZARD ASSET MANAGEMENT LLC	0.16%	99.86K	2.31M	39.28K	+64.84%
Jun 30, 2025	TREXQUANT INVESTMENT LP	0.16%	96.17K	2.22M	-72.8K	-43.08%
Jun 30, 2025		0.16%	95.98K	2.22M	-27.7K	-22.40%
Jun 30, 2025	SPHERA FUNDS MANAGEMENT LTD.	0.14%	85.84K	1.98M	-40K	-31.79%
Jun 30, 2025	TWINBEECH CAPITAL LP	0.13%	81.88K	1.89M	4.45K	+5.74%
Jun 30, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.12%	74.72K	1.73M	46.75K	+167.18%
Jun 30, 2025	HIGHVISTA STRATEGIES LLC	0.1%	62.44K	1.44M	-12.12K	-16.26%
Jun 30, 2025	ECOR1 CAPITAL, LLC	2.37%	1.47M	33.95M	0	0
Jun 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.4%	247.87K	5.73M	-55.32K	-18.25%
Jun 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.4%	246.92K	5.7M	54.54K	+28.35%
Jun 30, 2025	NORTHERN TRUST CORP	0.55%	341.84K	7.9M	42.62K	+14.24%
Jun 30, 2025	TANG CAPITAL MANAGEMENT LLC	0.32%	200K	4.62M	50K	+33.33%
Jun 30, 2025	SQUAREPOINT OPS LLC	0.31%	189.57K	4.38M	132.12K	+229.98%
Jun 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.29%	182.07K	4.21M	-83.59K	-31.46%
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	18.08%	11.19M	258.48M	0	0
Jun 30, 2025	BLACKROCK, INC.	5.5%	3.4M	78.61M	529.89K	+18.44%
Jun 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.08%	49.5K	2.04M	0	0
Jun 30, 2025	FARALLON CAPITAL MANAGEMENT LLC	0.08%	48K	1.11M	0	0
Jun 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.08%	46.93K	1.08M	-9.35K	-16.61%
Jun 30, 2025	DARK FOREST CAPITAL MANAGEMENT LP	0.08%	46.86K	1.08M	2.18K	+4.89%
Jun 30, 2025	GILDER GAGNON HOWE & CO LLC	0.07%	45.41K	1.05M	-4.7K	-9.37%
Jun 30, 2025	AQUATIC CAPITAL MANAGEMENT LLC	0.07%	43.03K	993.92K	-19.44K	-31.12%
Jun 30, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.05%	30K	693K	-80K	-72.73%
Jun 30, 2025	TEJARA CAPITAL LTD	0.05%	29.8K	688.38K	29.8K	+100.00%
Jun 30, 2025	LESTER MURRAY ANTMAN DBA SIMPLYRICH	0.04%	24.32K	561K	0	0
Jun 30, 2025	ALGERT GLOBAL LLC	0.15%	92.48K	2.14M	51.82K	+127.45%
Jun 30, 2025	STEMPOINT CAPITAL LP	0.15%	89.93K	2.08M	-252.13K	-73.71%
Jun 30, 2025	STATE OF WISCONSIN INVESTMENT BOARD	0.11%	70.26K	1.62M	19.3K	+37.86%
Jun 30, 2025	TD ASSET MANAGEMENT INC	0.11%	65.24K	1.51M	-400	-0.61%
Jun 30, 2025	NEOS INVESTMENT MANAGEMENT LLC	0.08%	50.07K	1.16M	4.13K	+8.99%
Jun 30, 2025	HEALTHINVEST PARTNERS AB	0.08%	49.82K	1.15M	3.01K	+6.43%
Jun 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	4.72%	2.92M	67.46M	-409.65K	-12.30%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	4.08%	2.53M	58.33M	-1.13M	-30.91%
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	3.46%	2.14M	49.52M	1.77M	+469.18%
Jun 30, 2025	CORMORANT ASSET MANAGEMENT, LP	2.42%	1.5M	34.65M	-500K	-25.00%
Jun 30, 2025	STATE STREET CORP	2.24%	1.39M	32.07M	16.61K	+1.21%
Jun 30, 2025	WOODLINE PARTNERS LP	2.01%	1.24M	28.69M	-215.16K	-14.77%
Jun 30, 2025	ORBIMED ADVISORS LLC	1.96%	1.21M	27.96M	451.73K	+59.55%
Jun 30, 2025	PROSIGHT MANAGEMENT, LP	1.38%	853.9K	19.73M	164K	+23.77%
Jun 30, 2025	READYSTATE ASSET MANAGEMENT LP	1.12%	695.96K	16.08M	419.4K	+151.65%
Jun 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.34%	210.27K	4.86M	5.8K	+2.84%
Jun 30, 2025	SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)	0.29%	177.82K	4.11M	0	0
Jun 30, 2025	FIRST LIGHT ASSET MANAGEMENT, LLC	0.24%	149.6K	3.46M	-509.23K	-77.29%
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.37%	229.99K	5.31M	-138.95K	-37.66%
Jun 30, 2025	JUMP FINANCIAL, LLC	0.37%	228.43K	5.28M	134.4K	+142.93%
Jun 30, 2025	MORGAN STANLEY	0.51%	315.73K	7.29B	33.3K	+11.79%
Jun 30, 2025	QUINN OPPORTUNITY PARTNERS LLC	0.1%	59.89K	1.38M	8K	+15.42%
Jun 30, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.09%	55.13K	1.27M	-86.5K	-61.08%
Jun 30, 2025	WALLEYE CAPITAL LLC	0.09%	53.48K	1.24M	42.1K	+369.91%
Jun 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.08%	671.49K	15.51M	14.88K	+2.27%
Jun 30, 2025	LOGOS GLOBAL MANAGEMENT LP	0.81%	500K	11.55M	500K	+100.00%
Jun 30, 2025	FMR LLC	14.36%	8.89M	205.33M	4.67K	+0.05%
Jun 30, 2025	FIRST TURN MANAGEMENT, LLC	0.72%	447.42K	10.34M	17.26K	+4.01%
Jun 30, 2025	NATIONALE-NEDERLANDEN POWSZECHNE TOWARZYSTWO EMERYTALNE S.A.	0.61%	376.5K	8.7M	0	0
Jun 30, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0.23%	141.78K	3.28M	65.92K	+86.89%
Jun 30, 2025	JANUS HENDERSON GROUP PLC	7.21%	4.46M	103.05M	-137.76K	-3.00%
Jun 30, 2025	CITADEL ADVISORS LLC	1.99%	1.23M	28.44B	524.46K	+74.22%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.56%	348.49K	8.05B	62.21K	+21.73%
Jun 30, 2025	AMERIPRISE FINANCIAL INC	0.41%	255.59K	5.9M	-5.68K	-2.17%
Mar 31, 2025	NORTHERN TRUST CORP	0.48%	299.22K	8.08M	-9.58K	-3.10%
Mar 31, 2025	STATE STREET CORP	2.22%	1.37M	37.03M	103.55K	+8.17%
Mar 31, 2025	JANUS HENDERSON GROUP PLC	7.44%	4.6M	133.68M	1.04M	+29.07%
Mar 31, 2025	AVIDITY PARTNERS MANAGEMENT LP	0.42%	258K	6.97M	-483.9K	-65.22%
Mar 31, 2025	UBS GROUP AG	0.79%	488.48K	13.19M	263.39K	+117.02%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	1.21%	749.33K	20.23M	-45.44K	-5.72%
Mar 31, 2025	INVESCO LTD.	0.42%	258.11K	6.97M	-26.55K	-9.33%
Mar 31, 2025	AMERIPRISE FINANCIAL INC	0.42%	261.26K	7.05M	246.36K	+1,652.73%
Mar 31, 2025	VICTORY CAPITAL MANAGEMENT INC	0.43%	265.65K	7.17M	23.24K	+9.59%
Mar 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.61%	376.66K	10.17M	-244.72K	-39.38%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.64%	393.48K	10.62M	-141.92K	-26.51%
Mar 31, 2025	CITADEL ADVISORS LLC	1.14%	706.66K	19.08M	-654.21K	-48.07%
Mar 31, 2025	TUDOR INVESTMENT CORP ET AL	0.28%	174.35K	4.71M	174.35K	+100.00%
Mar 31, 2025	SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)	0.29%	177.82K	4.8M	-27.35K	-13.33%
Mar 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.3%	186.39K	5.03M	20.66K	+12.46%
Mar 31, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.31%	192.37K	5.6M	35.5K	+22.63%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.44%	273.64K	7.39M	508	+0.19%
Mar 31, 2025	READYSTATE ASSET MANAGEMENT LP	0.45%	276.56K	7.47M	-63.08K	-18.57%
Mar 31, 2025	MORGAN STANLEY	0.46%	282.43K	7.63M	64.6K	+29.65%
Mar 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.49%	303.19K	8.19M	73.8K	+32.17%
Mar 31, 2025	STEMPOINT CAPITAL LP	0.55%	342.06K	9.24M	196.19K	+134.49%
Mar 31, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.33%	204.47K	5.52M	0	0
Mar 31, 2025	ORBIMED ADVISORS LLC	1.23%	758.57K	20.48M	0	0
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.26%	780.91K	21.09M	65.95K	+9.22%
Mar 31, 2025	PERCEPTIVE ADVISORS LLC	1.57%	970.41K	26.2M	152.52K	+18.65%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.6%	368.94K	9.96M	339.46K	+1,151.86%
Mar 31, 2025	ENSIGN PEAK ADVISORS, INC	0.48%	294.75K	7.96M	152.45K	+107.13%
Mar 31, 2025	ECOR1 CAPITAL, LLC	2.38%	1.47M	39.69M	0	0
Mar 31, 2025	WOODLINE PARTNERS LP	2.36%	1.46M	39.34M	-395.09K	-21.33%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.25%	1.39M	37.61M	282.85K	+25.48%
Mar 31, 2025	PROSIGHT MANAGEMENT, LP	1.12%	689.9K	18.63M	360.13K	+109.21%
Mar 31, 2025	LORD, ABBETT & CO. LLC	1.08%	667.88K	18.03M	-599.92K	-47.32%
Mar 31, 2025	FIRST LIGHT ASSET MANAGEMENT, LLC	1.07%	658.82K	17.79M	345.04K	+109.96%
Mar 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.06%	656.61K	17.73M	271.81K	+70.64%
Mar 31, 2025	BIOIMPACT CAPITAL LLC	0.92%	567.19K	15.31M	337.19K	+146.61%
Mar 31, 2025	FIRST TURN MANAGEMENT, LLC	0.7%	430.16K	11.61M	46.56K	+12.14%
Mar 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.66%	408.68K	11.03M	63.76K	+18.49%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.46%	286.28K	7.73M	-94.07K	-24.73%
Mar 31, 2025	FRANKLIN RESOURCES INC	1.92%	1.19M	32.03M	689.19K	+138.59%
Mar 31, 2025	NATIONALE-NEDERLANDEN POWSZECHNE TOWARZYSTWO EMERYTALNE S.A.	0.61%	376.5K	10.17M	-52.9K	-12.32%
Mar 31, 2025	FMR LLC	14.38%	8.88M	239.87M	214.13K	+2.47%
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	18.11%	11.19M	302.12M	824.04K	+7.95%
Mar 31, 2025	ABRDN PLC	0.36%	224.79K	6.07M	160.72K	+250.84%
Mar 31, 2025	LOGOS GLOBAL MANAGEMENT LP	2.67%	1.65M	44.55M	400K	+32.00%
Mar 31, 2025	CORMORANT ASSET MANAGEMENT, LP	3.24%	2M	54M	-100K	-4.76%
Mar 31, 2025	VANGUARD GROUP INC	3.69%	2.28M	61.52M	142.33K	+6.66%
Mar 31, 2025	BLACKROCK, INC.	4.65%	2.87M	77.57M	147.15K	+5.40%
Mar 31, 2025	PARADIGM BIOCAPITAL ADVISORS LP	5.39%	3.33M	89.91M	-186.08K	-5.29%
Mar 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	5.91%	3.65M	98.67M	592.82K	+19.36%
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.43%	264.9K	7.15M	264.9K	+100.00%
Mar 31, 2024	STEMPOINT CAPITAL LP	0.28%	121.64K	4.58M	121.64K	+100.00%
Mar 31, 2024	CITADEL ADVISORS LLC	0.12%	52K	1.96M	51.3K	+7,328.57%
Mar 31, 2024	ADAGE CAPITAL PARTNERS GP, L.L.C.	6.31%	2.78M	104.5M	1.42M	+104.77%
Mar 31, 2024	VOYA INVESTMENT MANAGEMENT LLC	0.09%	40.65K	1.53M	40.65K	+100.00%
Mar 31, 2024	ZACKS INVESTMENT MANAGEMENT	0.09%	40.92K	1.54M	-17.89K	-30.41%
Mar 31, 2024	CITIGROUP INC	0.09%	41.57K	1.57M	37.75K	+986.28%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.51%	224.72K	8.46M	180.61K	+409.48%
Mar 31, 2024	STATE STREET CORP	0.91%	399.47K	15.04M	51.88K	+14.93%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	1.06%	467.55K	17.61M	59.36K	+14.54%
Mar 31, 2024	LORD, ABBETT & CO. LLC	1.23%	542.37K	20.42M	542.37K	+100.00%
Mar 31, 2024	VANGUARD GROUP INC	3.09%	1.36M	51.13M	378.48K	+38.64%
Mar 31, 2024	BLACKROCK INC.	3.85%	1.69M	63.78M	-68.11K	-3.87%
Mar 31, 2024	SQUAREPOINT OPS LLC	0.1%	43.15K	1.62M	-18.02K	-29.45%
Mar 31, 2024	ARTIA GLOBAL PARTNERS LP	0.11%	47.95K	1.81M	47.95K	+100.00%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.11%	48.69K	1.83M	-4.06K	-7.70%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.11%	49.26K	1.85M	3.12K	+6.76%
Mar 31, 2024	DEKABANK DEUTSCHE GIROZENTRALE	0.11%	49.5K	1.88M	0	0
Mar 31, 2024	ARTAL GROUP S.A.	0.11%	50K	1.88M	50K	+100.00%
Mar 31, 2024	CAPSTONE INVESTMENT ADVISORS, LLC	0.12%	52.3K	1.97M	52.3K	+100.00%
Mar 31, 2024	D. E. SHAW & CO., INC.	0.12%	54.64K	2.06M	54.64K	+100.00%
Mar 31, 2024	EAM INVESTORS, LLC	0.13%	55.97K	2.11M	55.97K	+100.00%
Mar 31, 2024	MACQUARIE GROUP LTD	0.14%	60K	2.26M	60K	+100.00%
Mar 31, 2024	ATIKA CAPITAL MANAGEMENT LLC	0.15%	64.5K	2.43M	64.5K	+100.00%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.18%	78.63K	2.96M	-2.95K	-3.62%
Mar 31, 2024	CANDRIAM S.C.A.	0.18%	80.01K	3.01M	80.01K	+100.00%
Mar 31, 2024	TWO SIGMA ADVISERS, LP	0.19%	83K	3.12M	59.4K	+251.69%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.18%	78.4K	2.95M	78.4K	+100.00%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.21%	92.9K	3.5M	92.9K	+100.00%
Mar 31, 2024	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.24%	104.5K	3.93M	104.5K	+100.00%
Mar 31, 2024	MORGAN STANLEY	0.28%	121.23K	4.56M	53.78K	+79.74%
Mar 31, 2024	LOGOS GLOBAL MANAGEMENT LP	0.34%	150K	5.65M	150K	+100.00%
Mar 31, 2024	SCHONFELD STRATEGIC ADVISORS LLC	0.35%	152.72K	5.75M	152.72K	+100.00%
Mar 31, 2024	SOLEUS CAPITAL MANAGEMENT, L.P.	0.36%	157.8K	5.94M	157.8K	+100.00%
Mar 31, 2024	SAMSARA BIOCAPITAL, LLC	0.41%	180.21K	6.78M	-180.21K	-50.00%
Mar 31, 2024	DRIEHAUS CAPITAL MANAGEMENT LLC	0.43%	191.06K	7.19M	191.06K	+100.00%
Mar 31, 2024	ALYESKA INVESTMENT GROUP, L.P.	0.44%	193.05K	7.27M	-4.44K	-2.25%
Mar 31, 2024	ALTITUDE CREST PARTNERS INC.	0.44%	193.3K	7.28M	193.3K	+100.00%
Mar 31, 2024	NORTHERN TRUST CORP	0.46%	201.98K	7.6M	-2.02K	-0.99%
Mar 31, 2024	SAMLYN CAPITAL, LLC	0.67%	296.39K	11.16M	296.39K	+100.00%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.79%	347.17K	13.07M	307.22K	+769.06%
Mar 31, 2024	AVIDITY PARTNERS MANAGEMENT LP	0.87%	384.25K	14.47M	384.25K	+100.00%
Mar 31, 2024	CORMORANT ASSET MANAGEMENT, LP	1.7%	750K	28.24M	750K	+100.00%
Mar 31, 2024	RTW INVESTMENTS, LP	2.27%	1M	37.65M	1M	+100.00%
Mar 31, 2024	JANUS HENDERSON GROUP PLC	4.47%	1.97M	73.96M	34.07K	+1.76%
Mar 31, 2024	BVF INC/IL	6.63%	2.92M	109.93M	-1.66M	-36.25%
Mar 31, 2024	ORBIMED ADVISORS LLC	9.71%	4.28M	160.97M	957.63K	+28.86%
Mar 31, 2024	BAILARD, INC.	0.02%	7.4K	278.61M	7.4K	+100.00%
Mar 31, 2024	EXCHANGE TRADED CONCEPTS, LLC	0.02%	7.54K	284.03K	-6.66K	-46.89%
Mar 31, 2024	INVESCO LTD.	0.02%	7.81K	293.93K	7.81K	+100.00%
Mar 31, 2024	LESTER MURRAY ANTMAN DBA SIMPLYRICH	0.02%	7.96K	300K	7.96K	+100.00%
Mar 31, 2024	CHICAGO PARTNERS INVESTMENT GROUP LLC	0.02%	8.46K	421.34K	8.46K	+100.00%
Mar 31, 2024	BELVEDERE TRADING LLC	0.02%	8.5K	320.03K	8.5K	+100.00%
Mar 31, 2024	AMERICAN INTERNATIONAL GROUP, INC.	0.02%	8.52K	320.93K	-72	-0.84%
Mar 31, 2024	METLIFE INVESTMENT MANAGEMENT, LLC	0.02%	9.06K	341.15K	-1.55K	-14.63%
Mar 31, 2024	SEI INVESTMENTS CO	0.02%	9.13K	343.9M	9.13K	+100.00%
Mar 31, 2024	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	9.74K	367K	4.4K	+82.35%
Mar 31, 2024	ORION PORTFOLIO SOLUTIONS, LLC	0.02%	10.96K	412.64K	10.96K	+100.00%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	0.04%	15.6K	587.23K	15.6K	+100.00%
Mar 31, 2024	JUMP FINANCIAL, LLC	0.04%	15.69K	590.77K	15.69K	+100.00%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.04%	16.11K	606.43M	6.23K	+63.01%
Mar 31, 2024	JPMORGAN CHASE & CO	0.04%	19.34K	728.27K	1.61K	+9.06%
Mar 31, 2024	CREDIT SUISSE AG/	0.04%	19.36K	728.94K	1.05K	+5.74%
Mar 31, 2024	RATAN CAPITAL MANAGEMENT LP	0.05%	20K	753K	20K	+100.00%
Mar 31, 2024	CAPULA MANAGEMENT LTD	0.05%	21.35K	803.9K	21.35K	+100.00%
Mar 31, 2024	CERITY PARTNERS LLC	0.05%	21.43K	806.88K	-39.5K	-64.83%
Mar 31, 2024	UBS GROUP AG	0.05%	22.2K	835.98K	22.2K	+100.00%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.05%	23.55K	886.66K	6.18K	+35.58%
Mar 31, 2024	SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)	0.05%	23.62K	889.18K	23.62K	+100.00%
Mar 31, 2024	STATE OF WISCONSIN INVESTMENT BOARD	0.05%	23.99K	903.22K	8.87K	+58.65%
Mar 31, 2024	RHUMBLINE ADVISERS	0.06%	26.92K	1.01M	838	+3.21%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.06%	27.06K	1.02M	15.61K	+136.43%
Mar 31, 2024	SWISS NATIONAL BANK	0.07%	31.8K	1.2M	0	0
Mar 31, 2024	OVATA CAPITAL MANAGEMENT LTD	0.09%	40K	1.51M	40K	+100.00%
Mar 31, 2024	RA CAPITAL MANAGEMENT, L.P.	20.82%	9.17M	345.09M	0	0
Mar 31, 2024	FMR LLC	17.6%	7.75M	291.75M	3.08M	+65.89%
Dec 31, 2023	SWISS NATIONAL BANK	0.07%	31.8K	341.21K	9K	+39.47%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.09%	39.95K	428.64K	25.4K	+174.67%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.1%	43.8K	469.99K	13.26K	+43.42%
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	0.1%	44.11K	473.28K	24.87K	+129.24%
Dec 31, 2023	AMERICAN CENTURY COMPANIES INC	0.03%	11.44K	122.78K	11.44K	+100.00%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.1%	46.14K	495.09K	-2.61K	-5.35%
Dec 31, 2023	BARCLAYS PLC	0.1%	47.72K	511K	29.8K	+166.28%
Dec 31, 2023	DEKABANK DEUTSCHE GIROZENTRALE	0.11%	49.5K	579K	0	0
Dec 31, 2023	JANNEY MONTGOMERY SCOTT LLC	0.11%	51.55K	553K	51.55K	+100.00%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.12%	52.75K	565.97K	-303	-0.57%
Dec 31, 2023	ZACKS INVESTMENT MANAGEMENT	0.13%	58.8K	630.97K	58.8K	+100.00%
Dec 31, 2023	CERITY PARTNERS LLC	0.13%	60.93K	653.81K	60.93K	+100.00%
Dec 31, 2023	SQUAREPOINT OPS LLC	0.13%	61.17K	656.33K	50.52K	+474.51%
Dec 31, 2023	MORGAN STANLEY	0.15%	67.45K	723.72K	46.99K	+229.72%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	0.16%	71.86K	771.02K	-28.76K	-28.58%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.18%	81.57K	875.29K	14.87K	+22.30%
Dec 31, 2023	ALYESKA INVESTMENT GROUP, L.P.	0.43%	197.49K	2.12M	22.49K	+12.85%
Dec 31, 2023	NORTHERN TRUST CORP	0.45%	204K	2.19M	11.32K	+5.87%
Dec 31, 2023	STATE STREET CORP	0.76%	347.59K	3.73M	16.01K	+4.83%
Dec 31, 2023	SAMSARA BIOCAPITAL, LLC	0.79%	360.41K	3.87M	0	0
Dec 31, 2023	EXCHANGE TRADED CONCEPTS, LLC	0.03%	14.2K	152.41K	3.6K	+33.97%
Dec 31, 2023	STATE OF WISCONSIN INVESTMENT BOARD	0.03%	15.12K	162.25K	4.66K	+44.48%
Dec 31, 2023	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0.04%	17.19K	184.47K	4.12K	+31.51%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	0.89%	408.19K	4.38M	21.39K	+5.53%
Dec 31, 2023	VANGUARD GROUP INC	2.14%	979.48K	10.51M	37.2K	+3.95%
Dec 31, 2023	ADAGE CAPITAL PARTNERS GP, L.L.C.	2.97%	1.36M	14.54M	205.48K	+17.87%
Dec 31, 2023	BLACKROCK INC.	3.86%	1.76M	18.91M	122.52K	+7.47%
Dec 31, 2023	ALLIANCEBERNSTEIN L.P.	0.04%	17.37K	186.38K	510	+3.02%
Dec 31, 2023	OLD WELL PARTNERS, LLC	0.02%	10.3K	110.52K	0	0
Dec 31, 2023	JANUS HENDERSON GROUP PLC	4.23%	1.93M	20.74M	-135.99K	-6.58%
Dec 31, 2023	ORBIMED ADVISORS LLC	7.26%	3.32M	35.6M	0	0
Dec 31, 2023	BVF INC/IL	10.02%	4.58M	49.14M	0	0
Dec 31, 2023	FMR LLC	10.22%	4.67M	50.12M	-1.68M	-26.45%
Dec 31, 2023	RA CAPITAL MANAGEMENT, L.P.	20.05%	9.17M	98.35M	0	0
Dec 31, 2023	JPMORGAN CHASE & CO	0.04%	17.74K	190.31K	-130.87K	-88.07%
Dec 31, 2023	METLIFE INVESTMENT MANAGEMENT, LLC	0.02%	10.61K	113.89K	0	0
Dec 31, 2023	CREDIT SUISSE AG/	0.04%	18.31K	196.47K	2.6K	+16.51%
Dec 31, 2023	TWO SIGMA ADVISERS, LP	0.05%	23.6K	253.23K	23.6K	+100.00%
Dec 31, 2023	RHUMBLINE ADVISERS	0.06%	26.09K	279.88K	-447	-1.68%
Dec 31, 2023	NEW YORK STATE COMMON RETIREMENT FUND	0.01%	5.05K	54K	-35	-0.69%
Dec 31, 2023	WELLS FARGO & COMPANY/MN	0.01%	5.29K	56.74K	1.02K	+23.99%
Dec 31, 2023	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.01%	5.34K	57K	5.34K	+100.00%
Dec 31, 2023	ALLSPRING GLOBAL INVESTMENTS HOLDINGS, LLC	0.06%	26.26K	281.81K	25.11K	+2,166.09%
Dec 31, 2023	CITADEL ADVISORS LLC	0.01%	5.6K	60.09K	3.2K	+133.33%
Dec 31, 2023	DEUTSCHE BANK AG\	0.02%	6.97K	74.82K	0	0
Dec 31, 2023	AMERICAN INTERNATIONAL GROUP, INC.	0.02%	8.6K	92.24K	-35	-0.41%
Dec 31, 2023	SG AMERICAS SECURITIES, LLC	0.02%	9.35K	100K	9.35K	+100.00%
Dec 31, 2023	LEGAL & GENERAL GROUP PLC	0.02%	9.88K	106.02K	0	0
Dec 31, 2023	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.03%	12.82K	137.52K	12.82K	+100.00%

Insiders

Among the JANX insiders holding of 6.59% of the stake in company, RA CAPITAL MANAGEMENT, L.P., , holds the largest shares of 10.14M. BREGUA CORP, 10 percent owner, is the second largest JANX insider with ownership of 3.75M shares. REARDON TIGHE, Acting Chief Financial Officer, stands third with possession of 633.67K shares of that stake.

Insiders	Designation	Shares Held
RA CAPITAL MANAGEMENT, L.P.		10.14M
BREGUA CORP	10 percent owner	3.75M
REARDON TIGHE	Acting Chief Financial Officer	633.67K
AVALON VENTURES XI, L.P.	10 percent owner	401.32K
CAMPBELL DAVID ALAN	President and CEO	284.98K
ORBIMED ADVISORS LLC	director	231.1K
THOMPSON PETER A.	director	231.1K
DIRAIMONDO THOMAS	Chief Scientific Officer	124.43K
MEYER ANDREW HOLLMAN	Chief Business Officer	83.1K
WINTER CHARLES M.	Chief Technical Officer	77.72K
MCIVER ZACHARIAH	Chief Medical Officer	23.29K
DOBEK MARIA	Vice President, Accounting	15.37K
LICHTER JAY	10 percent owner	7K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Jan 02, 2026	DOBEK MARIA	SALE	13.73	1.46K	20.07K	15.37K
Jan 02, 2026	MEYER ANDREW HOLLMAN	SALE	13.73	1.88K	25.8K	83.1K
Jan 02, 2026	DIRAIMONDO THOMAS	SALE	13.73	2.51K	34.39K	124.43K
Jan 02, 2026	CAMPBELL DAVID ALAN	SALE	13.73	8.07K	110.83K	284.98K
Jan 02, 2026	WINTER CHARLES M.	SALE	13.73	2.4K	32.97K	77.72K
Jan 02, 2026	MCIVER ZACHARIAH	SALE	13.73	2.71K	37.26K	23.29K
Dec 01, 2025	MEYER ANDREW HOLLMAN	SALE	33.52	633	21.22K	84.97K
Nov 14, 2025	MEYER ANDREW HOLLMAN	SALE	30.00	3.33K	99.99K	84.97K
Oct 28, 2025	MEYER ANDREW HOLLMAN	SALE	30.06	16.67K	500.99K	82.14K
May 01, 2025	MEYER ANDREW HOLLMAN	SALE	32.60	400	13.04K	82.14K
Apr 21, 2025	MEYER ANDREW HOLLMAN	SALE	30.00	3.33K	100.02K	82.14K
Mar 07, 2025	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	31.02	110.21K	3.42M	10.14M
Mar 06, 2025	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	30.78	372.09K	11.45M	10.03M
Mar 05, 2025	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	30.56	304.29K	9.3M	9.62M
Mar 03, 2025	MEYER ANDREW HOLLMAN	SALE	32.85	901	29.6K	82.14K
Feb 03, 2025	MEYER ANDREW HOLLMAN	SALE	43.60	100	4.36K	82.14K
Jan 07, 2025	CAMPBELL DAVID ALAN	SALE	60.00	5K	300K	293.05K
Jan 02, 2025	MEYER ANDREW HOLLMAN	SALE	57.37	200	11.47K	82.14K
Dec 24, 2024	CAMPBELL DAVID ALAN	SALE	56.19	25K	1.4M	217.05K
Dec 03, 2024	CAMPBELL DAVID ALAN	SALE	67.00	15K	1.01M	242.05K
Nov 25, 2024	CAMPBELL DAVID ALAN	SALE	52.04	6.72K	349.65K	257.05K
Oct 28, 2024	CAMPBELL DAVID ALAN	SALE	53.94	11.1K	598.91K	282.05K
Oct 18, 2024	AVALON VENTURES XI, L.P.	SALE	44.75	104.96K	4.7M	401.32K
Oct 18, 2024	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	44.75	1.2M	53.7M	9.32M
Oct 17, 2024	AVALON VENTURES XI, L.P.	SALE	50.02	1.84K	92.19K	6.37K
Oct 16, 2024	AVALON VENTURES XI, L.P.	SALE	50.80	10.96K	556.62K	6.45K
Sep 30, 2024	AVALON VENTURES XI, L.P.	SALE	46.24	958	44.3K	6.89K
Sep 27, 2024	DIRAIMONDO THOMAS	SALE	47.22	675	31.88K	97.94K
Sep 27, 2024	AVALON VENTURES XI, L.P.	SALE	46.19	1.83K	84.34K	6.93K
Sep 27, 2024	MEYER ANDREW HOLLMAN	SALE	45.96	50K	2.3M	67.59K
Sep 27, 2024	CAMPBELL DAVID ALAN	SALE	47.84	795	38.03K	307.05K
Sep 26, 2024	AVALON VENTURES XI, L.P.	SALE	47.77	7.91K	377.77K	555.73K
Sep 13, 2024	LICHTER JAY	SALE	46.68	3.82K	178.08K	7K
Sep 12, 2024	AVALON VENTURES XI, L.P.	SALE	47.00	30.61K	1.44M	573.23K
Sep 10, 2024	AVALON VENTURES XI, L.P.	SALE	46.66	6.65K	310.24K	603.84K
Sep 09, 2024	AVALON VENTURES XI, L.P.	SALE	42.33	2.18K	92.36K	7K
Sep 06, 2024	AVALON VENTURES XI, L.P.	SALE	42.00	20.99K	881.62K	612.68K
Jun 03, 2024	LICHTER JAY	SALE	54.75	131.2K	7.18M	633.67K
Jun 03, 2024	AVALON VENTURES XI, L.P.	SALE	54.75	131.2K	7.18M	633.67K
Jun 03, 2024	REARDON TIGHE	SALE	54.75	131.2K	7.18M	633.67K
Mar 04, 2024	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	0.00	1.4M	1.4K	1.4M
Nov 13, 2023	LICHTER JAY	PURCHASE	5.87	849.85K	4.99M	849.85K
Nov 13, 2023	REARDON TIGHE	PURCHASE	5.87	849.85K	4.99M	849.85K
Nov 13, 2023	AVALON VENTURES XI, L.P.	PURCHASE	5.87	849.85K	4.99M	849.85K
Jul 19, 2023	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	0.00	503.23K	503.23	503.23K
Dec 29, 2021	THOMPSON PETER A.	SALE	20.30	3.7K	75.11K	231.1K
Dec 29, 2021	ORBIMED ADVISORS LLC	SALE	20.30	3.7K	75.11K	231.1K
Dec 21, 2021	ORBIMED ADVISORS LLC	SALE	19.00	11.1K	210.9K	234.8K
Dec 21, 2021	THOMPSON PETER A.	SALE	19.00	11.1K	210.9K	234.8K
Dec 16, 2021	THOMPSON PETER A.	SALE	19.07	36.5K	696.06K	245.9K
Dec 16, 2021	ORBIMED ADVISORS LLC	SALE	19.07	36.5K	696.06K	245.9K
Jun 15, 2021	THOMPSON PETER A.	PURCHASE	17.00	117.65K	2M	282.4K
Jun 15, 2021	LICHTER JAY	PURCHASE	17.00	629.41K	10.7M	4.48M
Jun 15, 2021	AVALON VENTURES XI, L.P.	PURCHASE	17.00	629.41K	10.7M	4.48M
Jun 15, 2021	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	17.00	188.99K	3.21M	1.05M
Jun 15, 2021	BREGUA CORP	PURCHASE	17.00	58.82K	999.99K	3.75M
Jun 15, 2021	REARDON TIGHE	PURCHASE	17.00	629.41K	10.7M	4.48M
Jun 15, 2021	ORBIMED ADVISORS LLC	PURCHASE	17.00	117.65K	2M	282.4K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES39.66K9

NET SHARES-39.66K9

SHARES HELD860.97K9

% NET SHARES-104.61%0%

Frequently Asked Questions