How many institutions own ITOS stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own ITOS shares is 187, representing 90.28% of the company's common stock.

Who are the major shareholders selling iTeos Therapeutics, Inc. stock?

DAFNA CAPITAL MANAGEMENT LLC, in the last quarter, reduced its stake in ITOS by -33.98% restricting it's holding to 140.85 thousand shares of worth nearly $1.40M. ACADIAN ASSET MANAGEMENT LLC also lessened -65.22% of the ITOS shares from its portfolio, reducing its holding to 186.69 thousand shares of worth $1.86M. JPMORGAN CHASE & CO also shunned ITOS shares holding by -69.67% last quarter which brought its holding to 601.36 thousand shares worth $6.00M.

Investors who are buying ITOS stock?

As per its latest 13F filing, DIADEMA PARTNERS LP increased its stake in ITOS by 100% in the last quarter. The institutional holder raised its holding to 206.2 thousand shares having worth more than $2.06M. GABELLI & CO INVESTMENT ADVISERS, INC. also added 100% more shares of ITOS to its portfolio, raising its holding to 146.45 thousand shares of worth $1.46M. WELLINGTON MANAGEMENT GROUP LLP also increased its ITOS shares holding by 10.59% which brought its holding to 154.96 thousand shares worth $1.54M.

ITOS's major insiders: who are they?

The insider with the most stakes in ITOS is EcoR1 Capital, LLC , 10 percent owner at the company. Additionally, ITOS stock is highly held by Former 10% Owner RA CAPITAL MANAGEMENT, L.P. and Former 10% Owner GADICKE ANSBERT among others.

Did an insider recently sell ITOS stock?

Company executives, directors, and other insiders own 0.35% percent of iTeos Therapeutics, Inc.'s stock. Within the last six months, there have been 0 transaction(s) in which ITOS insiders have sold stock, totaling 0 shares. Insiders that have sold shares include DETHEUX MICHEL, HALLAL DAVID, and MPM BIOVENTURES 2018, L.P..

Which insider recently purchased ITOS stock?

There have been 0 transaction(s) during the past 6-months in which iTeos Therapeutics, Inc. insiders have bought stock, totalling 0 shares

How much of ITOS does insiders own?

Around 0 iTeos Therapeutics, Inc. shares are held by insiders, which represents about 0.35% of ITOS stock.

Who is the insider with the largest stake?

ITOS 10 percent owner, EcoR1 Capital, LLC holds the largest portfolio of the company's shares. ITOS shares owned by EcoR1 total nearly 10.69 million.

Which institution holds the most shares in ITOS?

DIADEMA PARTNERS LP is the largest institutional owner in ITOS which holds 206.2 thousand shares worth $2.06M or 0.47% of the total ITOS shares outstanding followed by DAFNA CAPITAL MANAGEMENT LLC with ownership of 140.85 thousand shares representing 0.32% of the ITOS ownership. GABELLI & CO INVESTMENT ADVISERS, INC. is the third largest stakeholder with 146.45 thousand shares or 0.34% of the ownership worth more than $1.46M.

Is iTeos Therapeutics, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the ITOS is concerned, it is a stock which is optionable.

Is there a short position on ITOS's shares?

Number of ITOS shares short is 2.97M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding ITOS shares are there?

As of today, 44.21M shares of ITOS are outstanding.

Is there many float in ITOS stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, ITOS has 33.24M shares in float.

ITOS short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for ITOS is 2.17.

iTeos Therapeutics (ITOS) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableNo

OptionableYes

Short Percent Of Outstanding Shares6.72

Short Percent Of Float8.32

Shares Outstanding44.21M

Shares Float33.24M

Shares Short2.97M

Short Ratio2.17

8.32%

Short % of Float

6.72%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

0.35% Percentage of Shares held by All Insiders

90.28% Percentage of Shares held by All Institutions

90.6% Percentage of Float held by Institutions

187

Number of Institutions Holding Shares

Institutional Ownership

About 90.28% of ITOS shares are held by financial institutions. DIADEMA PARTNERS LP is the top corporate investor, holding 206.2K shares valued at $2.06M. A 0.47% stake in iTeos Therapeutics, Inc. is owned by the company. DAFNA CAPITAL MANAGEMENT LLC owns 140.85K shares valued at $1.40M, which translates its holding of 0.32% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Jun 30, 2025	DIADEMA PARTNERS LP	0.47%	206.2K	2.06M	206.2K	+100.00%
Jun 30, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.32%	140.85K	1.4M	-72.5K	-33.98%
Jun 30, 2025	GABELLI & CO INVESTMENT ADVISERS, INC.	0.34%	146.45K	1.46M	146.45K	+100.00%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.36%	154.96K	1.54M	14.84K	+10.59%
Jun 30, 2025	ACADIAN ASSET MANAGEMENT LLC	0.43%	186.69K	1.86M	-350.1K	-65.22%
Jun 30, 2025	SUSQUEHANNA PORTFOLIO STRATEGIES, LLC	0.47%	204.71K	2.04M	204.71K	+100.00%
Jun 30, 2025	LMR PARTNERS LLP	1.26%	550K	5.48M	550K	+100.00%
Jun 30, 2025	NEWTYN MANAGEMENT, LLC	1.3%	567.42K	5.66M	567.42K	+100.00%
Jun 30, 2025	DLD ASSET MANAGEMENT, LP	1.32%	576.66K	5.75M	576.66K	+100.00%
Jun 30, 2025	STATE STREET CORP	1.36%	594.56K	5.93M	12.56K	+2.16%
Jun 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	1.37%	596.67K	5.95M	596.67K	+100.00%
Jun 30, 2025	JPMORGAN CHASE & CO	1.38%	601.36K	6M	-1.38M	-69.67%
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	0.18%	78.95K	787.12K	4.42K	+5.93%
Jun 30, 2025	SIMPLEX TRADING, LLC	0.24%	103.21K	1.03M	103.21K	+100.00%
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.24%	106.4K	1.06M	106.4K	+100.00%
Jun 30, 2025	EVERSEPT PARTNERS, LP	0.25%	109.32K	1.09M	-110.87K	-50.35%
Jun 30, 2025	JANE STREET GROUP, LLC	0.27%	116K	1.16M	116K	+100.00%
Jun 30, 2025	BARCLAYS PLC	0.29%	126K	1.26M	-2.98K	-2.31%
Jun 30, 2025	AMERIPRISE FINANCIAL INC	0.48%	207.79K	2.07M	9.89K	+4.99%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.56%	246.09K	2.45M	12.53K	+5.36%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.79%	342.5K	3.41M	342.5K	+100.00%
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	1.38%	602.1K	6M	-43.5K	-6.74%
Jun 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	1.15%	500K	4.99M	500K	+100.00%
Jun 30, 2025	SHAY CAPITAL LLC	0.48%	210.52K	2.1M	210.52K	+100.00%
Jun 30, 2025	ALPINE GLOBAL MANAGEMENT, LLC	0.52%	225K	2.24M	225K	+100.00%
Jun 30, 2025	ALMITAS CAPITAL LLC	1.12%	487.2K	4.86M	212.08K	+77.09%
Jun 30, 2025	RANGELEY CAPITAL, LLC	0.69%	302.08K	3.01M	302.08K	+100.00%
Jun 30, 2025	MARSHALL WACE, LLP	1.4%	611.65K	6.1M	492.09K	+411.59%
Jun 30, 2025	ORBIMED ADVISORS LLC	1.61%	700K	6.98M	700K	+100.00%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.61%	703.47K	7.02M	53.41K	+8.22%
Jun 30, 2025	BOXER CAPITAL MANAGEMENT, LLC	1.89%	825K	8.23M	825K	+100.00%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	1.91%	832.76K	8.3M	-348.49K	-29.50%
Jun 30, 2025	VANGUARD GROUP INC	3.82%	1.66M	16.59M	-62.3K	-3.61%
Jun 30, 2025	TANG CAPITAL MANAGEMENT LLC	8.78%	3.83M	38.15M	1.14M	+42.30%
Jun 30, 2025	BLACKROCK, INC.	10.5%	4.57M	45.61M	65.29K	+1.45%
Jun 30, 2025	ECOR1 CAPITAL, LLC	24.54%	10.69M	106.57M	10.69M	+100.00%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.36%	155.35K	1.55B	-432.07K	-73.55%
Jun 30, 2025	CITADEL ADVISORS LLC	0.35%	150.7K	1.5B	73.9K	+96.22%
Jun 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.55%	237.81K	2.37B	11.6K	+5.13%
Jun 30, 2025	MORGAN STANLEY	0.99%	429.34K	4.28B	178.21K	+70.96%
Jun 30, 2025	GABELLI FUNDS LLC	0.28%	120.59K	1.2M	120.59K	+100.00%
Jun 30, 2025		0.35%	154.42K	1.54M	-149.23K	-49.14%
Jun 30, 2025	INVESCO LTD.	0.19%	81.04K	807.92K	-4.17K	-4.89%
Jun 30, 2025	VERITION FUND MANAGEMENT LLC	0.35%	150.65K	1.5M	106.5K	+241.23%
Jun 30, 2025	NORTHERN TRUST CORP	0.59%	258.37K	2.58M	8.24K	+3.30%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.71%	308.66K	3.08M	128.56K	+71.38%
Jun 30, 2025	STONEPINE CAPITAL MANAGEMENT, LLC	0.71%	310.03K	3.09M	200.03K	+181.85%
Jun 30, 2025	NUVEEN, LLC	0.35%	154.42K	1.54M	-149.23K	-49.14%
Jun 30, 2025	ROYAL BANK OF CANADA	0.43%	185.76K	1.85M	184.05K	+10,769.51%
Jun 30, 2025	SILVER POINT CAPITAL L.P.	0.67%	290K	2.89M	290K	+100.00%
Jun 30, 2025	PEAPOD LANE CAPITAL LLC	0.39%	169.29K	1.69M	33.63K	+24.79%
Mar 31, 2025	CAPTION MANAGEMENT, LLC	0.36%	154.49K	922.32K	-355.34K	-69.70%
Mar 31, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.36%	154.72K	923.66K	16.13K	+11.64%
Mar 31, 2025	VANGUARD GROUP INC	3.99%	1.73M	10.31M	92.43K	+5.66%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.81%	348.36K	2.08M	-62.71K	-15.26%
Mar 31, 2025	HSBC HOLDINGS PLC	0.18%	76.99K	458.49K	29.59K	+62.41%
Mar 31, 2025	AMERICAN CENTURY COMPANIES INC	0.17%	74.53K	444.96K	6.6K	+9.71%
Mar 31, 2025	STONEPINE CAPITAL MANAGEMENT, LLC	0.25%	110K	656.7K	0	0
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	8.44%	3.65M	21.78M	1.56M	+74.41%
Mar 31, 2025	683 CAPITAL MANAGEMENT, LLC	4.05%	1.75M	10.45M	831.88K	+90.61%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	2.73%	1.18M	7.05M	-28.83K	-2.38%
Mar 31, 2025	VESTAL POINT CAPITAL, LP	2.08%	900K	5.37M	0	0
Mar 31, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	1.29%	557.94K	3.33M	-364.2K	-39.50%
Mar 31, 2025	AQR CAPITAL MANAGEMENT LLC	0.52%	226.21K	1.35M	106.26K	+88.59%
Mar 31, 2025	ACADIAN ASSET MANAGEMENT LLC	1.24%	536.79K	3.2M	66.64K	+14.17%
Mar 31, 2025	EVERSEPT PARTNERS, LP	0.51%	220.2K	1.31M	0	0
Mar 31, 2025	AMERIPRISE FINANCIAL INC	0.46%	197.9K	1.18M	-7.29K	-3.55%
Mar 31, 2025	TREXQUANT INVESTMENT LP	0.44%	188.5K	1.13M	8.53K	+4.74%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.33%	142.9K	853.11K	-929.7K	-86.68%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.32%	140.12K	836.51K	29.79K	+27.00%
Mar 31, 2025	BARCLAYS PLC	0.3%	128.98K	770K	-3.92K	-2.95%
Mar 31, 2025	K2 PRINCIPAL FUND, L.P.	0.28%	120.5K	719.39K	-64K	-34.69%
Mar 31, 2025	MARSHALL WACE, LLP	0.28%	119.56K	713.76K	119.56K	+100.00%
Mar 31, 2025	INVESCO LTD.	0.2%	85.2K	508.66K	762	+0.90%
Mar 31, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0.26%	112.09K	669.19K	49.91K	+80.28%
Mar 31, 2025	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.2%	84.5K	504.48K	84.5K	+100.00%
Mar 31, 2025	ALGERT GLOBAL LLC	0.18%	79.95K	477K	10.44K	+15.02%
Mar 31, 2025	IKARIAN CAPITAL, LLC	0.18%	78.59K	469.15K	0	0
Mar 31, 2025	CITADEL ADVISORS LLC	0.18%	76.8K	458.5K	-117K	-60.37%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.5%	650.05K	3.88M	5.15K	+0.80%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	1.49%	645.6K	3.85M	-191.6K	-22.89%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	1.36%	587.42K	3.51M	-143.07K	-19.59%
Mar 31, 2025	STATE STREET CORP	1.35%	582K	3.47M	-3.94K	-0.67%
Mar 31, 2025	MORGAN STANLEY	0.58%	251.13K	1.5M	514	+0.21%
Mar 31, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.49%	213.35K	1.27M	25K	+13.27%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.42%	180.1K	1.08M	118.77K	+193.66%
Mar 31, 2025	JPMORGAN CHASE & CO	4.59%	1.98M	11.84M	-86.13K	-4.16%
Mar 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.25%	107.76K	643.35K	-87.19K	-44.72%
Mar 31, 2025	D. E. SHAW & CO., INC.	0.24%	104.13K	621.63K	47.59K	+84.18%
Mar 31, 2025		0.31%	135.66K	809.86K	26.8K	+24.62%
Mar 31, 2025	VICTORY CAPITAL MANAGEMENT INC	0.24%	102.19K	610.06K	429	+0.42%
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.23%	101.1K	603.54K	-30.5K	-23.18%
Mar 31, 2025	TANG CAPITAL MANAGEMENT LLC	6.22%	2.69M	16.05M	2.47M	+1,112.90%
Mar 31, 2025	BLACKROCK, INC.	10.43%	4.51M	26.92M	707.74K	+18.62%
Mar 31, 2025	NORTHERN TRUST CORP	0.58%	250.13K	1.49M	-9.61K	-3.70%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.54%	233.56K	1.39M	34.37K	+17.25%
Mar 31, 2025	BVF INC/IL	7.11%	3.08M	18.36M	750K	+32.26%
Mar 31, 2025	BIOIMPACT CAPITAL LLC	4.04%	1.75M	10.42M	0	0
Mar 31, 2024	J. GOLDMAN & CO LP	0.23%	82.15K	1.12M	82.15K	+100.00%
Mar 31, 2024	RA CAPITAL MANAGEMENT, L.P.	12.33%	4.42M	60.25M	0	0
Mar 31, 2024	MPM ASSET MANAGEMENT LLC	7.64%	2.74M	37.36M	0	0
Mar 31, 2024	EMPOWERED FUNDS, LLC	0.16%	57.92K	789.99K	-63.31K	-52.23%
Mar 31, 2024	HRT FINANCIAL LP	0.14%	50.94K	694K	-7.68K	-13.10%
Mar 31, 2024	SWISS NATIONAL BANK	0.13%	45.9K	626.08K	0	0
Mar 31, 2024	RHUMBLINE ADVISERS	0.12%	41.35K	563.98K	1.15K	+2.87%
Mar 31, 2024	RUSSELL INVESTMENTS GROUP, LTD.	0.11%	39.13K	533.75K	-377	-0.95%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.1%	37.31K	508.85K	-45.48K	-54.93%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.1%	36.61K	499.29K	9.8K	+36.57%
Mar 31, 2024	FRANKLIN RESOURCES INC	0.1%	36.44K	497.02K	36.44K	+100.00%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.09%	31.83K	434.16K	-3.49K	-9.88%
Mar 31, 2024	K2 PRINCIPAL FUND, L.P.	0.06%	20K	272.8K	20K	+100.00%
Mar 31, 2024	LOS ANGELES CAPITAL MANAGEMENT LLC	0.08%	29.4K	400.99K	29.4K	+100.00%
Mar 31, 2024	CREDIT SUISSE AG/	0.07%	26.66K	363.66K	0	0
Mar 31, 2024	EXCHANGE TRADED CONCEPTS, LLC	0.07%	26.56K	362.21K	15.18K	+133.37%
Mar 31, 2024	TREXQUANT INVESTMENT LP	0.07%	25.89K	353.09K	-35.77K	-58.02%
Mar 31, 2024	ALPS ADVISORS INC	0.07%	25.28K	344.87K	88	+0.35%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.07%	24.8K	338.27K	24.8K	+100.00%
Mar 31, 2024	LIGHTHOUSE INVESTMENT PARTNERS, LLC	0.07%	24.47K	333.81K	24.47K	+100.00%
Mar 31, 2024	JUPITER ASSET MANAGEMENT LTD	0.06%	23.13K	315.53K	0	0
Mar 31, 2024	CREATIVE PLANNING	0.06%	20.64K	281.56K	2.44K	+13.43%
Mar 31, 2024	ALLIANZ ASSET MANAGEMENT GMBH	0.06%	20.54K	280.19K	20.54K	+100.00%
Mar 31, 2024	JPMORGAN CHASE & CO	0.05%	17.76K	242.22K	-5.49K	-23.63%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.05%	16.46K	224.51M	0	0
Mar 31, 2024	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.05%	16.16K	220K	-47.39K	-74.58%
Mar 31, 2024	GSA CAPITAL PARTNERS LLP	0.04%	15.45K	211K	-31.98K	-67.42%
Mar 31, 2024	FOX RUN MANAGEMENT, L.L.C.	0.04%	14.84K	202.47K	-12.91K	-46.52%
Mar 31, 2024	CORNERCAP INVESTMENT COUNSEL INC	0.04%	13.24K	180.59K	0	0
Mar 31, 2024	ECOR1 CAPITAL, LLC	5.58%	2M	27.27M	884.23K	+79.30%
Mar 31, 2024	MORGAN STANLEY	4.55%	1.63M	22.27M	500.86K	+44.27%
Mar 31, 2024	CITADEL ADVISORS LLC	3.26%	1.17M	15.94M	38.88K	+3.44%
Mar 31, 2024	BRAIDWELL LP	3.24%	1.16M	15.85M	1.16M	+100.00%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	2.46%	882.98K	12.04M	-84.42K	-8.73%
Mar 31, 2024	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	2.02%	723K	9.86M	0	0
Mar 31, 2024	GOLDMAN SACHS GROUP INC	2%	716.26K	9.77M	-25.81K	-3.48%
Mar 31, 2024	683 CAPITAL MANAGEMENT, LLC	2%	715K	9.75M	0	0
Mar 31, 2024	STATE STREET CORP	1.61%	577.55K	7.88M	25.99K	+4.71%
Mar 31, 2024	JACOBS LEVY EQUITY MANAGEMENT, INC	1.41%	504.55K	6.88M	-30.12K	-5.63%
Mar 31, 2024	SATURN V CAPITAL MANAGEMENT LLC	1.08%	387.1K	5.28M	-441.14K	-53.26%
Mar 31, 2024	BARCLAYS PLC	0.97%	346.42K	4.73M	33.84K	+10.83%
Mar 31, 2024	EAGLE ASSET MANAGEMENT INC	0.65%	233.58K	3.12M	233.58K	+100.00%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.57%	205.87K	2.81M	4.32K	+2.14%
Mar 31, 2024	KENNEDY CAPITAL MANAGEMENT LLC	0.41%	145.73K	1.99M	145.73K	+100.00%
Mar 31, 2024	D. E. SHAW & CO., INC.	0.38%	136.72K	1.86M	-25.34K	-15.64%
Mar 31, 2024	SECTORAL ASSET MANAGEMENT INC	0.37%	133.97K	1.83M	-86.09K	-39.12%
Mar 31, 2024	ALGERT GLOBAL LLC	0.36%	127.27K	1.74M	-1.59K	-1.23%
Mar 31, 2024	PANAGORA ASSET MANAGEMENT INC	0.34%	120.77K	1.65M	-3.75K	-3.01%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.32%	115.84K	1.58M	-8.31K	-6.69%
Mar 31, 2024	CUBIST SYSTEMATIC STRATEGIES, LLC	0.29%	103.98K	1.42M	-30.02K	-22.40%
Mar 31, 2024	SUSQUEHANNA PORTFOLIO STRATEGIES, LLC	0.28%	101.78K	1.39M	101.78K	+100.00%
Mar 31, 2024	UBS GROUP AG	0.16%	59.09K	806.04K	13.81K	+30.50%
Mar 31, 2024	SQUAREPOINT OPS LLC	0.16%	58.44K	797.08K	-42.36K	-42.03%
Mar 31, 2024	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.16%	57.92K	789.99K	-63.31K	-52.23%
Mar 31, 2024	BOXER CAPITAL, LLC	5.03%	1.8M	24.61M	0	0
Mar 31, 2024	BIOIMPACT CAPITAL LLC	4.87%	1.75M	23.81M	0	0
Mar 31, 2024	IKARIAN CAPITAL, LLC	0.28%	101.33K	1.38M	-245.15K	-70.76%
Mar 31, 2024	DAFNA CAPITAL MANAGEMENT LLC	0.28%	98.56K	1.34M	0	0
Mar 31, 2024	VICTORY CAPITAL MANAGEMENT INC	0.26%	93.76K	1.28M	13.97K	+17.50%
Mar 31, 2024	AQR CAPITAL MANAGEMENT LLC	0.24%	86.17K	1.18M	-7.83K	-8.33%
Mar 31, 2024	WELLINGTON MANAGEMENT GROUP LLP	0.24%	85.85K	1.17M	85.85K	+100.00%
Mar 31, 2024	INVESCO LTD.	0.24%	84.56K	1.15M	47.53K	+128.33%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.22%	80.05K	1.09M	52.84K	+194.13%
Mar 31, 2024	AMERIPRISE FINANCIAL INC	0.22%	78.78K	1.07M	6.06K	+8.34%
Mar 31, 2024	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.21%	75.68K	1.03M	-168	-0.22%
Mar 31, 2024	BLACKROCK INC.	11.48%	4.11M	56.13M	-146.93K	-3.45%
Mar 31, 2024	VANGUARD GROUP INC	4.19%	1.5M	20.47M	9.66K	+0.65%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	2.21%	791.17K	10.79M	18.03K	+2.33%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	2%	717.3K	9.78M	18.4K	+2.63%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	1.63%	583.52K	7.96M	14.66K	+2.58%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	1.04%	371.1K	5.06M	177.7K	+91.88%
Mar 31, 2024	CITIGROUP INC	0.83%	295.98K	4.04M	-48.82K	-14.16%
Mar 31, 2024	NORTHERN TRUST CORP	0.7%	249.8K	3.41M	-7.05K	-2.74%
Mar 31, 2024	ACADIAN ASSET MANAGEMENT LLC	0.68%	244.71K	3.34M	244.71K	+100.00%
Mar 31, 2024	PRUDENTIAL FINANCIAL INC	0.68%	241.89K	3.3M	-101.1K	-29.48%
Mar 31, 2024	READYSTATE ASSET MANAGEMENT LP	0.52%	186.9K	2.55M	45.11K	+31.82%
Dec 31, 2023	VANGUARD GROUP INC	4.17%	1.49M	16.33M	-322.82K	-17.80%
Dec 31, 2023	BIOIMPACT CAPITAL LLC	4.88%	1.75M	19.12M	0	0
Dec 31, 2023	BOXER CAPITAL, LLC	5.04%	1.8M	19.75M	0	0
Dec 31, 2023	MPM ASSET MANAGEMENT LLC	7.65%	2.74M	29.99M	0	0
Dec 31, 2023	BLACKROCK INC.	11.91%	4.26M	46.67M	-789.22K	-15.63%
Dec 31, 2023	RA CAPITAL MANAGEMENT, L.P.	12.34%	4.42M	48.37M	0	0
Dec 31, 2023	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.18%	63.55K	696K	41.56K	+188.93%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.18%	64.68K	708.22K	-38.8K	-37.49%
Dec 31, 2023	AMERIPRISE FINANCIAL INC	0.2%	72.72K	796.28K	-60.5K	-45.41%
Dec 31, 2023	BOOTHBAY FUND MANAGEMENT, LLC	0.21%	75.7K	828.9K	1.72K	+2.33%
Dec 31, 2023	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.21%	75.85K	830.51K	-2.4K	-3.06%
Dec 31, 2023	VICTORY CAPITAL MANAGEMENT INC	0.22%	79.79K	873.73K	-19.34K	-19.51%
Dec 31, 2023	QUBE RESEARCH & TECHNOLOGIES LTD	0.23%	82.78K	906.45K	82.78K	+100.00%
Dec 31, 2023	GROUP ONE TRADING, L.P.	0.24%	85.73K	938.72M	85.73K	+100.00%
Dec 31, 2023	AQR CAPITAL MANAGEMENT LLC	0.26%	94K	1.03M	34.62K	+58.30%
Dec 31, 2023	DAFNA CAPITAL MANAGEMENT LLC	0.28%	98.56K	1.08M	0	0
Dec 31, 2023	SQUAREPOINT OPS LLC	0.28%	100.8K	1.1M	75.59K	+299.87%
Dec 31, 2023	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.34%	121.23K	1.33M	-55.58K	-31.43%
Dec 31, 2023	EMPOWERED FUNDS, LLC	0.34%	121.23K	1.33B	10.92K	+9.90%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.35%	124.15K	1.36M	-154.81K	-55.49%
Dec 31, 2023	PANAGORA ASSET MANAGEMENT INC	0.35%	124.51K	1.36M	-21.77K	-14.88%
Dec 31, 2023	ALGERT GLOBAL LLC	0.36%	128.86K	1.41M	32.68K	+33.98%
Dec 31, 2023	CUBIST SYSTEMATIC STRATEGIES, LLC	0.37%	134K	1.47M	120.93K	+924.72%
Dec 31, 2023	FMR LLC	0.4%	141.54K	1.55M	879	+0.62%
Dec 31, 2023	READYSTATE ASSET MANAGEMENT LP	0.4%	141.79K	1.55M	36.1K	+34.16%
Dec 31, 2023	D. E. SHAW & CO., INC.	0.45%	162.06K	1.77M	47.6K	+41.59%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.54%	193.4K	2.12M	133.5K	+222.87%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.56%	201.55K	2.21M	-8.62K	-4.10%
Dec 31, 2023	VONTOBEL HOLDING LTD.	0.62%	220.06K	2.41M	64.98K	+41.90%
Dec 31, 2023	SECTORAL ASSET MANAGEMENT INC	0.62%	220.06K	2.41M	64.98K	+41.90%
Dec 31, 2023	NORTHERN TRUST CORP	0.72%	256.85K	2.81M	-20.39K	-7.35%
Dec 31, 2023	BARCLAYS PLC	0.87%	312.58K	3.42M	-9.74K	-3.02%
Dec 31, 2023	PRUDENTIAL FINANCIAL INC	0.96%	342.99K	3.76M	91.29K	+36.27%
Dec 31, 2023	CITIGROUP INC	0.96%	344.8K	3.78M	258.47K	+299.38%
Dec 31, 2023	IKARIAN CAPITAL, LLC	0.97%	346.47K	3.79M	0	0
Dec 31, 2023	ARTAL GROUP S.A.	1.12%	400K	4.38M	0	0
Dec 31, 2023	JACOBS LEVY EQUITY MANAGEMENT, INC	1.49%	534.66K	5.85M	74.95K	+16.30%
Dec 31, 2023	STATE STREET CORP	1.54%	551.56K	6.04M	-1.03M	-65.12%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.59%	568.86K	6.23M	36.77K	+6.91%
Dec 31, 2023	RENAISSANCE TECHNOLOGIES LLC	1.95%	698.9K	7.65M	304.9K	+77.39%
Dec 31, 2023	683 CAPITAL MANAGEMENT, LLC	2%	715K	7.83M	-95K	-11.73%
Dec 31, 2023	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	2.02%	723K	7.92M	0	0
Dec 31, 2023	GOLDMAN SACHS GROUP INC	2.07%	742.07K	8.13M	132.86K	+21.81%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	2.16%	773.14K	8.47M	72.19K	+10.30%
Dec 31, 2023	SATURN V CAPITAL MANAGEMENT LLC	2.31%	828.23K	9.07M	-166.52K	-16.74%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	2.7%	967.4K	10.59M	-65.44K	-6.34%
Dec 31, 2023	ECOR1 CAPITAL, LLC	3.12%	1.12M	12.21M	1.12M	+100.00%
Dec 31, 2023	CITADEL ADVISORS LLC	3.16%	1.13M	12.37M	122.22K	+12.13%
Dec 31, 2023	MORGAN STANLEY	3.16%	1.13M	12.39M	869.74K	+332.28%
Dec 31, 2023	BVF INC/IL	3.52%	1.26M	13.79M	0	0

Insiders

Among the ITOS insiders holding of 0.35% of the stake in company, ECOR1 CAPITAL, LLC, 10 percent owner, holds the largest shares of 10.69M. RA CAPITAL MANAGEMENT, L.P., Former 10% Owner, is the second largest ITOS insider with ownership of 5.71M shares. GADICKE ANSBERT, Former 10% Owner, stands third with possession of 3.45M shares of that stake.

Insiders	Designation	Shares Held
ECOR1 CAPITAL, LLC	10 percent owner	10.69M
RA CAPITAL MANAGEMENT, L.P.	Former 10% Owner	5.71M
GADICKE ANSBERT	Former 10% Owner	3.45M
LEWIS JOSEPH		3.14M
DAVIS AARON I.	director	2.49M
MPM BIOVENTURES 2014, L.P.	Former 10% Owner	2.11M
MPM BIOVENTURES 2018, L.P.	Former 10% Owner	2.11M
BOXER CAPITAL, LLC		1.8M
GALL MATTHEW	Chief Financial Officer	65.43K
BINISZKIEWICZ DETLEV	director	0
MCGRATH YVONNE	Chief Scientific Officer	0
LAGER JOANNE JENKINS	Chief Medical Officer	0
HALLAL DAVID	director	0
DETHEUX MICHEL	Chief Executive Officer	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Jun 10, 2025	DETHEUX MICHEL	SALE	10.02	43.88K	439.71K	0
Jun 09, 2025	DETHEUX MICHEL	SALE	10.03	43.88K	440.14K	0
Jun 06, 2025	HALLAL DAVID	SALE	10.24	38.23K	391.45K	0
Jun 06, 2025	DETHEUX MICHEL	SALE	10.21	43.88K	448.04K	0
Jun 05, 2025	HALLAL DAVID	SALE	10.15	38.23K	388K	0
Jun 05, 2025	DETHEUX MICHEL	SALE	10.15	43.88K	445.4K	0
Jun 04, 2025	DETHEUX MICHEL	SALE	10.10	43.88K	443.22K	0
Jun 04, 2025	HALLAL DAVID	SALE	10.07	38.23K	384.95K	0
May 15, 2025	ECOR1 CAPITAL, LLC	PURCHASE	8.00	3.3M	26.4M	10.69M
May 14, 2025	ECOR1 CAPITAL, LLC	PURCHASE	7.41	1.66M	12.29M	7.39M
May 13, 2025	MPM BIOVENTURES 2018, L.P.	SALE	8.06	630.19K	5.08M	2.11M
May 13, 2025	GADICKE ANSBERT	SALE	8.06	1.03M	8.32M	3.45M
May 13, 2025	MPM BIOVENTURES 2014, L.P.	SALE	8.06	630.19K	5.08M	2.11M
Nov 19, 2024	GALL MATTHEW	PURCHASE	7.73	5K	38.64K	65.43K
May 10, 2024	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	0.00	5.71M	5.71K	5.71M
Oct 12, 2023	GALL MATTHEW	PURCHASE	8.37	5K	41.85K	19.43K
Aug 23, 2023	BOXER CAPITAL, LLC	SALE	16.87	219.64K	3.71M	1.8M
Jun 08, 2022	HALLAL DAVID	SALE	20.39	11.9K	242.62K	0
May 11, 2022	DAVIS AARON I.	SALE	17.53	891	15.62K	2.49M
May 10, 2022	DAVIS AARON I.	SALE	24.77	4.85K	120.11K	2.49M
May 09, 2022	DAVIS AARON I.	SALE	18.25	337.11K	6.15M	2.15M
May 02, 2022	DAVIS AARON I.	SALE	27.53	92.7K	2.55M	2.82M
Apr 29, 2022	DAVIS AARON I.	SALE	28.22	10K	282.15K	3.03M
Apr 28, 2022	DAVIS AARON I.	SALE	27.01	115K	3.11M	2.92M
Apr 18, 2022	DETHEUX MICHEL	SALE	31.87	11.47K	365.45K	26.3K
Mar 22, 2022	DAVIS AARON I.	PURCHASE	31.88	21.3K	678.94K	3.16M
Mar 21, 2022	DETHEUX MICHEL	SALE	33.44	5.82K	194.69K	38.88K
Mar 17, 2022	BOXER CAPITAL, LLC	SALE	35.25	575.2K	20.28M	3.14M
Mar 17, 2022	LEWIS JOSEPH	SALE	35.25	575.2K	20.28M	3.14M
Mar 11, 2022	LAGER JOANNE JENKINS	SALE	36.01	3.5K	126.04K	0
Mar 01, 2022	MCGRATH YVONNE	SALE	36.76	10K	367.57K	0
Feb 23, 2022	DETHEUX MICHEL	SALE	35.32	544	19.21K	34.7K
Feb 11, 2022	LAGER JOANNE JENKINS	SALE	36.27	1.52K	55.06K	0
Jan 25, 2022	DETHEUX MICHEL	SALE	36.21	4.41K	159.76K	49.2K
Jan 14, 2022	LAGER JOANNE JENKINS	SALE	39.58	723	28.62K	0
Jan 05, 2022	MPM BIOVENTURES 2018, L.P.	SALE	42.03	18.14K	762.21K	2.74M
Jan 05, 2022	MPM BIOVENTURES 2014, L.P.	SALE	42.03	18.14K	762.21K	2.74M
Jan 05, 2022	GADICKE ANSBERT	SALE	42.03	30.35K	1.28M	4.48M
Jan 04, 2022	MPM BIOVENTURES 2018, L.P.	SALE	46.47	7.67K	356.47K	2.76M
Jan 04, 2022	MPM BIOVENTURES 2014, L.P.	SALE	46.47	7.67K	356.47K	2.76M
Jan 04, 2022	BOXER CAPITAL, LLC	SALE	45.48	2.52K	114.47K	0
Jan 04, 2022	GADICKE ANSBERT	SALE	46.47	12.83K	596.16K	4.52M
Jan 03, 2022	BOXER CAPITAL, LLC	SALE	50.63	731	37.01K	46.48K
Jan 03, 2022	LAGER JOANNE JENKINS	SALE	51.90	7K	363.3K	0
Jan 03, 2022	BINISZKIEWICZ DETLEV	SALE	51.90	3.5K	181.65K	0
Dec 27, 2021	GALL MATTHEW	SALE	46.45	5K	232.25K	14.43K
Dec 22, 2021	DETHEUX MICHEL	SALE	45.37	9.49K	430.7K	63.7K
Dec 21, 2021	DETHEUX MICHEL	SALE	45.06	5.58K	251.43K	78.2K
Dec 20, 2021	HALLAL DAVID	SALE	43.57	50K	2.18M	0
Dec 20, 2021	DETHEUX MICHEL	SALE	43.94	9.11K	400.34K	78.2K
Dec 17, 2021	LAGER JOANNE JENKINS	SALE	41.00	7K	287K	0
Dec 10, 2021	LAGER JOANNE JENKINS	SALE	34.50	3.5K	120.75K	0
Dec 07, 2021	MPM BIOVENTURES 2014, L.P.	SALE	34.11	1.49K	50.96K	2.89M
Dec 07, 2021	MPM BIOVENTURES 2018, L.P.	SALE	34.11	1.49K	50.96K	2.89M
Dec 06, 2021	GADICKE ANSBERT	SALE	32.35	14.17K	458.5K	4.77M
Dec 06, 2021	MPM BIOVENTURES 2018, L.P.	SALE	35.04	60	2.1K	2.9M
Dec 06, 2021	MPM BIOVENTURES 2014, L.P.	SALE	35.04	60	2.1K	2.9M
Dec 03, 2021	MPM BIOVENTURES 2018, L.P.	SALE	36.26	179	6.49K	2.92M
Dec 03, 2021	MPM BIOVENTURES 2014, L.P.	SALE	36.26	179	6.49K	2.92M
Dec 03, 2021	GADICKE ANSBERT	SALE	36.26	300	10.88K	4.78M

Frequently Asked Questions