How many institutions own HOWL stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own HOWL shares is 78, representing 49.19% of the company's common stock.

Who are the major shareholders selling Werewolf Therapeutics, Inc. stock?

GOLDMAN SACHS GROUP INC, in the last quarter, reduced its stake in HOWL by -73.47% restricting it's holding to 60.34 thousand shares of worth nearly $118.87K. BLACKROCK, INC. also lessened -72.01% of the HOWL shares from its portfolio, reducing its holding to 101.32 thousand shares of worth $199.61K. TOWER RESEARCH CAPITAL LLC (TRC) also shunned HOWL shares holding by -58.24% last quarter which brought its holding to 6 thousand shares worth $11.83K.

Investors who are buying HOWL stock?

As per its latest 13F filing, CUBIST SYSTEMATIC STRATEGIES, LLC increased its stake in HOWL by 100% in the last quarter. The institutional holder raised its holding to 46.71 thousand shares having worth more than $92.02K. GEODE CAPITAL MANAGEMENT, LLC also added 0.86% more shares of HOWL to its portfolio, raising its holding to 330.79 thousand shares of worth $651.83K. VANGUARD GROUP INC also increased its HOWL shares holding by 8.46% which brought its holding to 1.41 million shares worth $2.77M.

HOWL's major insiders: who are they?

The insider with the most stakes in HOWL is RA CAPITAL MANAGEMENT, L.P. , at the company. Additionally, HOWL stock is highly held by Former 10% Owner MPM BioVentures 2014, L.P. and Former 10% Owner GADICKE ANSBERT among others.

Did an insider recently sell HOWL stock?

Company executives, directors, and other insiders own 5.96% percent of Werewolf Therapeutics, Inc.'s stock. Within the last six months, there have been 104 transaction(s) in which HOWL insiders have sold stock, totaling 5.78M shares. Insiders that have sold shares include EVNIN LUKE, GADICKE ANSBERT, and MPM BIOVENTURES 2014, L.P..

Which insider recently purchased HOWL stock?

There have been 0 transaction(s) during the past 6-months in which Werewolf Therapeutics, Inc. insiders have bought stock, totalling 0 shares

How much of HOWL does insiders own?

Around 469.93M Werewolf Therapeutics, Inc. shares are held by insiders, which represents about 5.96% of HOWL stock.

Who is the insider with the largest stake?

HOWL , RA CAPITAL MANAGEMENT, L.P. holds the largest portfolio of the company's shares. HOWL shares owned by RA total nearly 6.24 million.

Which institution holds the most shares in HOWL?

NORTHERN TRUST CORP is the largest institutional owner in HOWL which holds 65.84 thousand shares worth $129.70K or 0.15% of the total HOWL shares outstanding followed by CUBIST SYSTEMATIC STRATEGIES, LLC with ownership of 46.71 thousand shares representing 0.1% of the HOWL ownership. EDGEWOOD MANAGEMENT LLC is the third largest stakeholder with 50 thousand shares or 0.11% of the ownership worth more than $98.50K.

Is Werewolf Therapeutics, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the HOWL is concerned, it is a stock which is optionable.

Is there a short position on HOWL's shares?

Number of HOWL shares short is 982.02K. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding HOWL shares are there?

As of today, 45.73M shares of HOWL are outstanding.

Is there many float in HOWL stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, HOWL has 29.61M shares in float.

HOWL short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for HOWL is 4.09.

Werewolf Therapeutics (HOWL) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares2.15

Short Percent Of Float3.02

Shares Outstanding45.73M

Shares Float29.61M

Shares Short982.02K

Short Ratio4.09

3.02%

Short % of Float

2.15%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

5.96% Percentage of Shares held by All Insiders

49.19% Percentage of Shares held by All Institutions

52.3% Percentage of Float held by Institutions

Number of Institutions Holding Shares

Institutional Ownership

About 49.19% of HOWL shares are held by financial institutions. NORTHERN TRUST CORP is the top corporate investor, holding 65.84K shares valued at $129.70K. A 0.15% stake in Werewolf Therapeutics, Inc. is owned by the company. CUBIST SYSTEMATIC STRATEGIES, LLC owns 46.71K shares valued at $92.02K, which translates its holding of 0.1% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	NORTHERN TRUST CORP	0.15%	65.84K	129.7K	0	0
Sep 30, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0.1%	46.71K	92.02K	46.71K	+100.00%
Sep 30, 2025	EDGEWOOD MANAGEMENT LLC	0.11%	50K	98.5K	0	0
Sep 30, 2025	GOLDMAN SACHS GROUP INC	0.13%	60.34K	118.87K	-167.1K	-73.47%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.74%	330.79K	651.83K	2.83K	+0.86%
Sep 30, 2025	BIOIMPACT CAPITAL LLC	5.36%	2.41M	4.75M	0	0
Sep 30, 2025	BLACKROCK, INC.	0.23%	101.32K	199.61K	-260.66K	-72.01%
Sep 30, 2025	DC FUNDS, LP	1.31%	589.1K	1.16M	0	0
Sep 30, 2025	SPHERA FUNDS MANAGEMENT LTD.	1.39%	626.81K	1.23M	0	0
Sep 30, 2025	VANGUARD GROUP INC	3.13%	1.41M	2.77M	109.8K	+8.46%
Sep 30, 2025	TOWER RESEARCH CAPITAL LLC (TRC)	0.01%	6K	11.83K	-8.37K	-58.24%
Sep 30, 2025	FINANCIAL PERSPECTIVES, INC	0.02%	6.75K	13.3K	0	0
Sep 30, 2025	UBS GROUP AG	0.03%	12.78K	25.17K	9.34K	+271.61%
Sep 30, 2025	POINT72 ASIA (SINGAPORE) PTE. LTD.	0.03%	13.02K	25.64K	-7.11K	-35.33%
Sep 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.04%	17.81K	35.08K	-74.36K	-80.68%
Sep 30, 2025	MORGAN STANLEY	0.04%	19.25K	37.93K	-7.95K	-29.22%
Sep 30, 2025	TRUE WEALTH DESIGN, LLC	0%	0	-	-13	-100.00%
Sep 30, 2025	JUMP FINANCIAL, LLC	0%	0	-	-11.35K	-100.00%
Sep 30, 2025	Y-INTERCEPT (HONG KONG) LTD	0%	0	-	-84.42K	-100.00%
Sep 30, 2025	QUADRATURE CAPITAL LTD	0%	0	-	-25.79K	-100.00%
Sep 30, 2025	SAVANT CAPITAL, LLC	0%	0	-	-21.28K	-100.00%
Sep 30, 2025	MARSHALL WACE, LLP	0%	0	-	-103.79K	-100.00%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0%	0	-	-459	-100.00%
Sep 30, 2025	OPTIVER HOLDING B.V.	0%	22	43	22	+100.00%
Sep 30, 2025	EVERSOURCE WEALTH ADVISORS, LLC	0%	35	69	-132	-79.04%
Sep 30, 2025	SBI SECURITIES CO., LTD.	0%	41	81	1	+2.50%
Sep 30, 2025	PLANTE MORAN FINANCIAL ADVISORS, LLC	0%	50	99	0	0
Sep 30, 2025	TFC FINANCIAL MANAGEMENT, INC.	0.01%	2.5K	4.93K	0	0
Sep 30, 2025	GROUP ONE TRADING, L.P.	0.01%	2.67K	5.26K	2.67K	+100.00%
Sep 30, 2025	FEDERATED HERMES, INC.	0.01%	4.39K	8.64K	0	0
Sep 30, 2025	CETERA INVESTMENT ADVISERS	0.02%	10.2K	20.09K	10.2K	+100.00%
Sep 30, 2025	FMR LLC	0.03%	11.28K	22.23K	0	0
Sep 30, 2025	HBK SORCE ADVISORY LLC	0.03%	13.23K	23.28K	0	0
Sep 30, 2025	BARCLAYS PLC	0.03%	13.28K	26.15K	39	+0.29%
Sep 30, 2025	RAYMOND JAMES FINANCIAL INC	0.03%	14.44K	28.44K	1.39K	+10.67%
Sep 30, 2025	REGAL INVESTMENT ADVISORS LLC	0.06%	27.2K	53.59K	0	0
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.21%	93.04K	183.29K	13.44K	+16.88%
Sep 30, 2025	CITADEL ADVISORS LLC	0.34%	154.53K	304.43K	154.53K	+100.00%
Sep 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.52%	235.71K	464.34K	0	0
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.7%	317.05K	624.59K	-379.64K	-54.49%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	4.07%	1.83M	3.61M	-298.73K	-14.03%
Sep 30, 2025	CERTUITY, LLC	0.03%	15K	29.55K	0	0
Sep 30, 2025	SIMPLEX TRADING, LLC	0.03%	15.64K	30K	8.64K	+123.40%
Sep 30, 2025	MPM ASSET MANAGEMENT LLC	9.58%	4.31M	8.49M	0	0
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0%	793	1.56K	-2.82K	-78.05%
Sep 30, 2025	ROYAL BANK OF CANADA	0%	806	1K	-9.74K	-92.36%
Sep 30, 2025	ROSSBY FINANCIAL, LCC	0%	860	1.68K	0	0
Sep 30, 2025	JPMORGAN CHASE & CO	0%	1.12K	2.21K	-9.78K	-89.70%
Sep 30, 2025	NISA INVESTMENT ADVISORS, LLC	0%	1.38K	2.71K	0	0
Sep 30, 2025	CWM, LLC	0%	1.57K	3K	-6.88K	-81.43%
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	14.85%	6.68M	13.16M	0	0
Sep 30, 2025	CITIGROUP INC	0.02%	8.66K	17.06K	8.34K	+2,598.13%
Sep 30, 2025	ADVISOR GROUP HOLDINGS, INC.	0.02%	9.63K	13.3K	0	0
Sep 30, 2025	LARSON FINANCIAL GROUP LLC	0.02%	10K	19.7K	0	0
Sep 30, 2025	VIRTU FINANCIAL LLC	0.03%	12.23K	24K	12.23K	+100.00%
Sep 30, 2025	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.23%	102K	200.94K	0	0
Sep 30, 2025	STATE STREET CORP	0.26%	119.17K	234.76K	0	0
Sep 30, 2025	JANE STREET GROUP, LLC	0.6%	268.58K	529.1K	-106.36K	-28.37%
Sep 30, 2025	PFM HEALTH SCIENCES, LP	0.89%	401.11K	790.19K	0	0
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	1.01%	456K	898.32K	139.7K	+44.17%
Sep 30, 2025	HIGHLINE WEALTH PARTNERS LLC	0.01%	5K	9.85K	-5K	-50.00%
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.04%	20.14K	39.67K	-25.28K	-55.66%
Sep 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.07%	29.25K	57.62K	-15.01K	-33.91%
Sep 30, 2025	ACADIAN ASSET MANAGEMENT LLC	0.08%	34.29K	67K	-26.99K	-44.05%
Sep 30, 2025	TWO SIGMA ADVISERS, LP	0.08%	34.6K	68.16K	-22K	-38.87%
Sep 30, 2025	VONTOBEL HOLDING LTD.	0.08%	36K	70.92K	-4K	-10.00%
Sep 30, 2025	HRT FINANCIAL LP	0.09%	39.86K	78K	-2.62K	-6.17%
Jun 30, 2025	MARSHALL WACE, LLP	0.23%	103.79K	113.13K	103.79K	+100.00%
Jun 30, 2025	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.23%	102K	111.18K	62.41K	+157.67%
Jun 30, 2025	Y-INTERCEPT (HONG KONG) LTD	0.19%	84.42K	92.02K	84.42K	+100.00%
Jun 30, 2025	NORTHERN TRUST CORP	0.15%	65.84K	71.76K	-192.62K	-74.53%
Jun 30, 2025	VONTOBEL HOLDING LTD.	0.09%	40K	43.6K	5K	+14.29%
Jun 30, 2025	REGAL INVESTMENT ADVISORS LLC	0.06%	27.2K	29.65K	0	0
Jun 30, 2025	POINT72 ASIA (SINGAPORE) PTE. LTD.	0.04%	20.13K	21.94K	20.13K	+100.00%
Jun 30, 2025	CERTUITY, LLC	0.03%	15K	16.35K	0	0
Jun 30, 2025	ROYAL BANK OF CANADA	0.02%	10.54K	11K	7.76K	+279.38%
Jun 30, 2025	RAYMOND JAMES FINANCIAL INC	0.03%	13.04K	14.22K	13.04K	+100.00%
Jun 30, 2025	EDGEWOOD MANAGEMENT LLC	0.11%	50K	54.5K	0	0
Jun 30, 2025	STATE STREET CORP	0.26%	119.17K	129.89K	-325.1K	-73.18%
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.18%	79.6K	86.77K	30.26K	+61.33%
Jun 30, 2025	ACADIAN ASSET MANAGEMENT LLC	0.14%	61.28K	66K	-189.4K	-75.56%
Jun 30, 2025	TWO SIGMA ADVISERS, LP	0.13%	56.6K	61.69K	-20.4K	-26.49%
Jun 30, 2025	QUADRATURE CAPITAL LTD	0.06%	25.79K	27.98K	25.79K	+100.00%
Jun 30, 2025	AVANTAX ADVISORY SERVICES, INC.	0.02%	10.2K	11.12K	10.2K	+100.00%
Jun 30, 2025	LARSON FINANCIAL GROUP LLC	0.02%	10K	10.9K	0	0
Jun 30, 2025	FMR LLC	0.03%	11.28K	12.3K	6.82K	+152.95%
Jun 30, 2025	TOWER RESEARCH CAPITAL LLC (TRC)	0.03%	14.38K	15.67K	5.24K	+57.26%
Jun 30, 2025	SAVANT CAPITAL, LLC	0.05%	21.28K	23.19K	21.28K	+100.00%
Jun 30, 2025		0.02%	10K	10.9K	10K	+100.00%
Jun 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.1%	44.26K	48.24K	44.26K	+100.00%
Jun 30, 2025	TWO SIGMA INVESTMENTS, LP	0.1%	45.42K	49.51K	-12.71K	-21.86%
Jun 30, 2025	HBK SORCE ADVISORY LLC	0.03%	13.23K	14.42K	-314	-2.32%
Jun 30, 2025	FEDERATED HERMES, INC.	0.01%	4.39K	4.78K	-1.74K	-28.43%
Jun 30, 2025	FINANCIAL PERSPECTIVES, INC	0.02%	6.75K	7.36K	0	0
Jun 30, 2025	JUMP FINANCIAL, LLC	0.03%	11.35K	12.37K	11.35K	+100.00%
Jun 30, 2025	MORGAN STANLEY	0.06%	27.2K	29.65M	-80.63K	-74.77%
Jun 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.2%	92.17K	100.46M	10.5K	+12.86%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.51%	227.44K	247.91M	115.46K	+103.10%
Jun 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.52%	235.71K	256.92K	0	0
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.7%	316.3K	344.77K	252.4K	+394.99%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.73%	327.96K	357.56K	-389.57K	-54.29%
Jun 30, 2025	BLACKROCK, INC.	0.8%	361.98K	394.56K	-1.31M	-78.35%
Jun 30, 2025	JANE STREET GROUP, LLC	0.83%	374.94K	408.68K	374.94K	+100.00%
Jun 30, 2025	PFM HEALTH SCIENCES, LP	0.89%	401.11K	437.21K	-2.11M	-84.00%
Jun 30, 2025	DC FUNDS, LP	1.31%	589.1K	642.12K	0	0
Jun 30, 2025	SPHERA FUNDS MANAGEMENT LTD.	1.39%	626.81K	683.22K	0	0
Jun 30, 2025	HRT FINANCIAL LP	0.09%	42.48K	46K	42.48K	+100.00%
Jun 30, 2025	BARCLAYS PLC	0.03%	13.24K	14K	-32.13K	-70.82%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	1.55%	696.7K	759.4K	-87.92K	-11.21%
Jun 30, 2025	VANGUARD GROUP INC	2.89%	1.3M	1.42M	-211.19K	-13.99%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	4.73%	2.13M	2.32M	25.88K	+1.23%
Jun 30, 2025	BIOIMPACT CAPITAL LLC	5.36%	2.41M	2.63M	0	0
Jun 30, 2025	MPM ASSET MANAGEMENT LLC	9.58%	4.31M	4.7M	0	0
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	14.85%	6.68M	7.28M	536.43K	+8.73%
Jun 30, 2025	SIMPLEX TRADING, LLC	0.02%	7K	7K	5.11K	+270.32%
Jun 30, 2025	CWM, LLC	0.02%	8.45K	9K	1.66K	+24.51%
Jun 30, 2025	ADVISOR GROUP HOLDINGS, INC.	0.02%	9.63K	10.49K	0	0
Jun 30, 2025	JPMORGAN CHASE & CO	0.02%	10.9K	11.88K	-5.11K	-31.94%
Jun 30, 2025	TWO SIGMA SECURITIES, LLC	0.05%	22.41K	24.43K	22.41K	+100.00%
Jun 30, 2025	HIGHLINE WEALTH PARTNERS LLC	0.02%	10K	10.9K	10K	+100.00%
Jun 30, 2025	JAIN GLOBAL LLC	0.06%	26.98K	29.41K	26.98K	+100.00%
Mar 31, 2025	INVESCO LTD.	0.03%	14.23K	13.84K	-357	-2.45%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	1.75%	784.62K	762.81K	188.33K	+31.58%
Mar 31, 2025	STATE STREET CORP	0.99%	444.27K	431.92K	17.5K	+4.10%
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	13.71%	6.14M	5.97M	0	0
Mar 31, 2025	EDGEWOOD MANAGEMENT LLC	0.11%	50K	48.61K	0	0
Mar 31, 2025	UBS GROUP AG	0.04%	17.69K	17.19K	-12.81K	-41.99%
Mar 31, 2025	JPMORGAN CHASE & CO	0.04%	16.01K	15.57K	-46.92K	-74.56%
Mar 31, 2025	MPM ASSET MANAGEMENT LLC	9.61%	4.31M	4.19M	25.69K	+0.60%
Mar 31, 2025	DEUTSCHE BANK AG\	0.23%	101.63K	98.58K	0	0
Mar 31, 2025		0.16%	73.37K	71.33K	73.37K	+100.00%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.14%	63.9K	62.12K	7K	+12.30%
Mar 31, 2025	WALLEYE CAPITAL LLC	0.13%	59.35K	57.7K	-37.5K	-38.72%
Mar 31, 2025	SEI INVESTMENTS CO	0.05%	21.32K	20.73K	0	0
Mar 31, 2025	VANGUARD GROUP INC	3.37%	1.51M	1.47M	88.47K	+6.23%
Mar 31, 2025	RUBRIC CAPITAL MANAGEMENT LP	2.98%	1.33M	1.3M	0	0
Mar 31, 2025	BIOIMPACT CAPITAL LLC	5.37%	2.41M	2.34M	20.8K	+0.87%
Mar 31, 2025	SPHERA FUNDS MANAGEMENT LTD.	1.4%	626.81K	609.39K	0	0
Mar 31, 2025	PFM HEALTH SCIENCES, LP	5.59%	2.51M	2.44M	-398.95K	-13.73%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	4.69%	2.1M	2.04M	24.27K	+1.17%
Mar 31, 2025	BLACKROCK, INC.	3.73%	1.67M	1.63M	-28.58K	-1.68%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.6%	717.52K	697.68K	14.97K	+2.13%
Mar 31, 2025	DC FUNDS, LP	1.31%	589.1K	572.73K	0	0
Mar 31, 2025	NORTHERN TRUST CORP	0.58%	258.46K	251.27K	14.07K	+5.76%
Mar 31, 2025	ACADIAN ASSET MANAGEMENT LLC	0.56%	250.68K	242K	8.41K	+3.47%
Mar 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.53%	235.71K	229.15K	0	0
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.25%	111.99K	108.87K	-29.85K	-21.04%
Mar 31, 2025	MORGAN STANLEY	0.24%	107.83K	104.83K	-30.32K	-21.94%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.21%	95.71K	93.05K	23.85K	+33.19%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.19%	84.61K	82.42K	-110.14K	-56.56%
Mar 31, 2025	AQR CAPITAL MANAGEMENT LLC	0.18%	81.67K	79.4K	81.67K	+100.00%
Mar 31, 2025	TWO SIGMA ADVISERS, LP	0.17%	77K	74.86K	-62.1K	-44.64%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.14%	62.41K	60.67K	-8.89K	-12.47%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.13%	58.13K	56.52K	-35.31K	-37.79%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.11%	49.34K	47.97K	15.48K	+45.71%
Mar 31, 2025	BARCLAYS PLC	0.1%	45.36K	45K	-14.39K	-24.08%
Mar 31, 2025	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.09%	39.59K	38.49K	-70K	-63.88%
Mar 31, 2025	VONTOBEL HOLDING LTD.	0.08%	35K	34.03K	35K	+100.00%
Mar 31, 2025	RHUMBLINE ADVISERS	0.07%	31.23K	30.35K	2.32K	+8.01%
Mar 31, 2025	REGAL INVESTMENT ADVISORS LLC	0.06%	27.2K	26.45K	0	0
Mar 31, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.05%	22.24K	21.62K	7.37K	+49.60%
Mar 31, 2025	CITIGROUP INC	0.05%	21.91K	21.3K	-1.82K	-7.68%
Mar 31, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0.04%	18.65K	18.13K	780	+4.36%
Mar 31, 2025	WELLS FARGO & COMPANY/MN	0.04%	17.86K	17.36K	875	+5.15%
Mar 31, 2025	CERTUITY, LLC	0.03%	15K	14.58K	0	0
Mar 31, 2025	CITADEL ADVISORS LLC	0.03%	13.6K	13.22K	-400	-2.86%
Mar 31, 2025	HBK SORCE ADVISORY LLC	0.03%	13.54K	13.17K	-1.82K	-11.83%
Mar 31, 2025	SQUAREPOINT OPS LLC	0.03%	11.83K	11.5K	11.83K	+100.00%
Mar 31, 2025	IEQ CAPITAL, LLC	0.02%	10.84K	10.54K	10.84K	+100.00%
Mar 31, 2025	LARSON FINANCIAL GROUP LLC	0.02%	10K	9.72K	0	0
Mar 31, 2025	COREBRIDGE FINANCIAL, INC.	0.03%	15.36K	14.93K	199	+1.31%
Mar 31, 2024	RA CAPITAL MANAGEMENT, L.P.	16.8%	6.14M	39.82M	0	0
Mar 31, 2024	FINANCIAL PERSPECTIVES, INC	0.02%	6.75K	43.74K	0	0
Mar 31, 2024	OMERS ADMINISTRATION CORP	0.03%	10.8K	69.98K	10.8K	+100.00%
Mar 31, 2024	HBK SORCE ADVISORY LLC	0.04%	13.23K	85.71K	-13.23K	-50.00%
Mar 31, 2024	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.07%	25.24K	164K	25.24K	+100.00%
Mar 31, 2024	ALYESKA INVESTMENT GROUP, L.P.	0.64%	235.71K	1.53M	-200K	-45.90%
Mar 31, 2024	Y-INTERCEPT (HONG KONG) LTD	0.04%	14.15K	91.72K	14.15K	+100.00%
Mar 31, 2024	BREVAN HOWARD CAPITAL MANAGEMENT LP	0.05%	18.91K	122.54K	18.91K	+100.00%
Mar 31, 2024	MORGAN STANLEY	0.06%	20.58K	133.35K	19.98K	+3,329.83%
Mar 31, 2024	MARSHALL WACE, LLP	0.07%	26.28K	170.32K	26.28K	+100.00%
Mar 31, 2024	DENALI ADVISORS LLC	0.07%	26.6K	172.37K	26.6K	+100.00%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.08%	27.7K	179.5K	27.7K	+100.00%
Mar 31, 2024	ROYCE & ASSOCIATES LP	0.1%	37.32K	241.84K	37.32K	+100.00%
Mar 31, 2024	HRT FINANCIAL LP	0.1%	37.63K	243K	37.63K	+100.00%
Mar 31, 2024	CUBIST SYSTEMATIC STRATEGIES, LLC	0.11%	40.65K	263.41K	40.65K	+100.00%
Mar 31, 2024	NORTHERN TRUST CORP	0.13%	48.5K	314.29K	-1.15K	-2.31%
Mar 31, 2024	EDGEWOOD MANAGEMENT LLC	0.14%	50K	324K	0	0
Mar 31, 2024	STATE STREET CORP	0.19%	71.17K	461.17K	-12.3K	-14.74%
Mar 31, 2024	JPMORGAN CHASE & CO	0.19%	71.18K	461.27K	71.1K	+85,663.86%
Mar 31, 2024	CITIGROUP INC	0.2%	71.56K	463.68K	71.56K	+100.00%
Mar 31, 2024	MAN GROUP PLC	0.22%	79.64K	516.06K	79.64K	+100.00%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.23%	84.2K	546K	-23.31K	-21.68%
Mar 31, 2024	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.23%	85.09K	551.36K	0	0
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	0.31%	111.63K	723.33K	48.7K	+77.40%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.32%	117.01K	758.24K	114.63K	+4,808.26%
Mar 31, 2024	JANE STREET GROUP, LLC	0.43%	157.23K	1.02M	142.74K	+985.29%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.47%	172.79K	1.12M	172.79K	+100.00%
Mar 31, 2024	ACADIAN ASSET MANAGEMENT LLC	0.47%	172.88K	1.12M	94.21K	+119.75%
Mar 31, 2024	TWO SIGMA ADVISERS, LP	0.68%	247.6K	1.6M	70.3K	+39.65%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	0.71%	259.68K	1.68M	65.37K	+33.64%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	1.55%	565.42K	3.66M	121.06K	+27.24%
Mar 31, 2024	SPHERA FUNDS MANAGEMENT LTD.	1.71%	626.81K	4.06M	0	0
Mar 31, 2024	EAGLE HEALTH INVESTMENTS LP	1.91%	700K	4.54M	700K	+100.00%
Mar 31, 2024	MONASHEE INVESTMENT MANAGEMENT LLC	2.43%	890K	5.77M	890K	+100.00%
Mar 31, 2024	VANGUARD GROUP INC	3.03%	1.11M	7.18M	233.91K	+26.78%
Mar 31, 2024	RUBRIC CAPITAL MANAGEMENT LP	4.43%	1.62M	10.5M	-314.32K	-16.24%
Mar 31, 2024	JANUS HENDERSON GROUP PLC	4.62%	1.69M	10.92M	1.69M	+100.00%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	5.14%	1.88M	12.19M	-214.97K	-10.26%
Mar 31, 2024	BIOIMPACT CAPITAL LLC	6.53%	2.39M	15.47M	0	0
Mar 31, 2024	VERITION FUND MANAGEMENT LLC	1.56%	571.47K	3.7M	571.47K	+100.00%
Mar 31, 2024	ADAGE CAPITAL PARTNERS GP, L.L.C.	8.21%	3M	19.44M	-33.66K	-1.11%
Mar 31, 2024	MPM ASSET MANAGEMENT LLC	11.71%	4.28M	27.76M	0	0
Mar 31, 2024	BALYASNY ASSET MANAGEMENT L.P.	0.06%	23.05K	149.35K	23.05K	+100.00%
Mar 31, 2024	POINT72 ASIA (SINGAPORE) PTE. LTD.	0.06%	23.26K	150.75K	23.26K	+100.00%
Mar 31, 2024	RAYMOND JAMES FINANCIAL SERVICES ADVISORS, INC.	0.06%	23.66K	153.31K	23.66K	+100.00%
Mar 31, 2024	SQUAREPOINT OPS LLC	0.07%	24.59K	159.37K	24.59K	+100.00%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.07%	24.98K	161.86K	24.98K	+100.00%
Mar 31, 2024	BLACKROCK INC.	0.45%	164.79K	1.07M	92.56K	+128.16%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.51%	185.06K	1.2M	38.32K	+26.12%
Mar 31, 2024	LAURION CAPITAL MANAGEMENT LP	0.55%	201.24K	1.3M	122.02K	+154.04%
Mar 31, 2024	DC FUNDS, LP	1.61%	589.1K	3.82M	0	0
Mar 31, 2024	PFM HEALTH SCIENCES, LP	8.22%	3.01M	19.48M	-461.44K	-13.31%
Mar 31, 2024	LIGHTHOUSE INVESTMENT PARTNERS, LLC	0%	0	-	-22.47K	-100.00%
Mar 31, 2024	PRUDENTIAL FINANCIAL INC	0%	0	-	-15.4K	-100.00%
Mar 31, 2024	GROUP ONE TRADING, L.P.	0%	0	-	-100	-100.00%
Mar 31, 2024	UBS GROUP AG	0%	37	240	-963	-96.30%
Mar 31, 2024	WELLS FARGO & COMPANY/MN	0%	194	1.26K	40	+25.97%
Mar 31, 2024	SIMPLEX TRADING, LLC	0%	202	1K	-5.5K	-96.45%
Mar 31, 2024	MACQUARIE GROUP LTD	0%	940	6	940	+100.00%
Dec 31, 2023	RUBRIC CAPITAL MANAGEMENT LP	5.43%	1.94M	7.47M	0	0
Dec 31, 2023	BANK OF AMERICA CORP /DE/	5.88%	2.1M	8.09M	564.16K	+36.83%
Dec 31, 2023	BIOIMPACT CAPITAL LLC	6.7%	2.39M	9.22M	0	0
Dec 31, 2023	ADAGE CAPITAL PARTNERS GP, L.L.C.	8.51%	3.03M	11.71M	2.03M	+203.24%
Dec 31, 2023	PFM HEALTH SCIENCES, LP	9.73%	3.47M	13.39M	909.9K	+35.57%
Dec 31, 2023	PRUDENTIAL FINANCIAL INC	0.04%	15.4K	59.44K	0	0
Dec 31, 2023	VIRTU FINANCIAL LLC	0.06%	20.38K	79K	20.38K	+100.00%
Dec 31, 2023	LIGHTHOUSE INVESTMENT PARTNERS, LLC	0.06%	22.47K	86.74K	22.47K	+100.00%
Dec 31, 2023	HBK SORCE ADVISORY LLC	0.07%	26.45K	102.11K	0	0
Dec 31, 2023	NORTHERN TRUST CORP	0.14%	49.65K	191.64K	23.58K	+90.46%
Dec 31, 2023	EDGEWOOD MANAGEMENT LLC	0.14%	50K	193K	0	0
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	0.18%	62.92K	242.88K	4.8K	+8.25%
Dec 31, 2023	BLACKROCK INC.	0.2%	72.23K	278.8K	-4.89K	-6.33%
Dec 31, 2023	ACADIAN ASSET MANAGEMENT LLC	0.22%	78.67K	303K	0	0
Dec 31, 2023	LAURION CAPITAL MANAGEMENT LP	0.22%	79.21K	305.76K	-443.69K	-84.85%
Dec 31, 2023	STATE STREET CORP	0.23%	83.47K	322.19K	32.7K	+64.41%
Dec 31, 2023	MPM ASSET MANAGEMENT LLC	12.02%	4.28M	16.54M	0	0
Dec 31, 2023	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.24%	85.09K	328.43K	-10.43K	-10.92%
Dec 31, 2023	RENAISSANCE TECHNOLOGIES LLC	0.3%	107.51K	415K	62.31K	+137.85%
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	0.41%	146.74K	566.4K	146.74K	+100.00%
Dec 31, 2023	TWO SIGMA ADVISERS, LP	0.5%	177.3K	684.38K	177.3K	+100.00%
Dec 31, 2023	SCHONFELD STRATEGIC ADVISORS LLC	0%	0	-	-174.72K	-100.00%
Dec 31, 2023	TOWER RESEARCH CAPITAL LLC (TRC)	0%	0	-	-2.35K	-100.00%
Dec 31, 2023	RA CAPITAL MANAGEMENT, L.P.	17.23%	6.14M	23.72M	0	0
Dec 31, 2023	GHP INVESTMENT ADVISORS, INC.	0%	0	-	-80	-100.00%
Dec 31, 2023	ROYAL BANK OF CANADA	0%	0	-	-335	-100.00%
Dec 31, 2023	JPMORGAN CHASE & CO	0%	83	320	-665	-88.90%
Dec 31, 2023	CITADEL ADVISORS LLC	0%	100	386	100	+100.00%
Dec 31, 2023	GROUP ONE TRADING, L.P.	0%	100	386K	100	+100.00%
Dec 31, 2023	WELLS FARGO & COMPANY/MN	0%	154	594	8	+5.48%
Dec 31, 2023	BAYSTATE WEALTH MANAGEMENT LLC	0%	300	1.16K	300	+100.00%
Dec 31, 2023	MORGAN STANLEY	0%	600	2.32K	-1.9K	-76.00%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	0.55%	194.31K	750.21K	20.06K	+11.51%
Dec 31, 2023	ALYESKA INVESTMENT GROUP, L.P.	1.22%	435.71K	1.68M	37.9K	+9.53%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	1.25%	444.36K	1.72M	-22.26K	-4.77%
Dec 31, 2023	DC FUNDS, LP	1.65%	589.1K	2.27M	0	0
Dec 31, 2023	SPHERA FUNDS MANAGEMENT LTD.	1.76%	626.81K	2.42M	0	0
Dec 31, 2023	VANGUARD GROUP INC	2.45%	873.44K	3.37M	325.79K	+59.49%
Dec 31, 2023	UBS GROUP AG	0%	1K	3.86K	0	0
Dec 31, 2023	QUBE RESEARCH & TECHNOLOGIES LTD	0.01%	2.38K	9.2K	2.38K	+119,100.00%
Dec 31, 2023	SIMPLEX TRADING, LLC	0.02%	5.7K	21K	-257	-4.32%
Dec 31, 2023		0.02%	6.75K	26.06K	3K	+80.00%
Dec 31, 2023	CERTUITY, LLC	0.03%	10K	38.6K	10K	+100.00%
Dec 31, 2023	JANE STREET GROUP, LLC	0.04%	14.49K	55.92K	14.49K	+100.00%

Insiders

Among the HOWL insiders holding of 5.96% of the stake in company, RA CAPITAL MANAGEMENT, L.P., , holds the largest shares of 6.24M. MPM BIOVENTURES 2014, L.P., Former 10% Owner, is the second largest HOWL insider with ownership of 4.78M shares. GADICKE ANSBERT, Former 10% Owner, stands third with possession of 4.78M shares of that stake.

Insiders	Designation	Shares Held
RA CAPITAL MANAGEMENT, L.P.		6.24M
MPM BIOVENTURES 2014, L.P.	Former 10% Owner	4.78M
GADICKE ANSBERT	Former 10% Owner	4.78M
FLYNN JAMES E	10 percent owner	2.55M
EVNIN LUKE	director	2.4M
ASANUMA SAKAE		2.07M
TAIHO VENTURES LLC	10 percent owner	2.07M
ARKIN BIO VENTURES 2 L.P.	10 percent owner	2.05M
LAZARUS ALON		2.05M
LONGWOOD FUND III GP, LLC	10 percent owner	1.68M
SPHERA GLOBAL HEALTHCARE MANAGEMENT LP	10 percent owner	788K
LEONARD REID	Chief Operating Officer	122.16K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Jan 07, 2026	EVNIN LUKE	SALE	0.64	11.92K	7.63K	2.4M
Jan 06, 2026	EVNIN LUKE	SALE	0.65	40.76K	26.49K	2.41M
Jan 05, 2026	EVNIN LUKE	SALE	0.64	18.38K	11.76K	2.45M
Jan 02, 2026	EVNIN LUKE	SALE	0.63	18.57K	11.7K	2.47M
Dec 31, 2025	EVNIN LUKE	SALE	0.62	24.96K	15.48K	2.49M
Dec 30, 2025	EVNIN LUKE	SALE	0.61	34.85K	21.26K	2.52M
Dec 29, 2025	EVNIN LUKE	SALE	0.61	108.61K	66.25K	2.55M
Dec 26, 2025	EVNIN LUKE	SALE	0.63	35.63K	22.45K	2.66M
Dec 24, 2025	EVNIN LUKE	SALE	0.65	16.31K	10.6K	2.69M
Dec 23, 2025	EVNIN LUKE	SALE	0.63	71.43K	45K	2.71M
Dec 22, 2025	EVNIN LUKE	SALE	0.69	59.31K	40.92K	2.78M
Dec 17, 2025	EVNIN LUKE	SALE	1.14	9.98K	11.38K	2.84M
Dec 16, 2025	EVNIN LUKE	SALE	1.05	14.55K	15.28K	2.85M
Dec 15, 2025	EVNIN LUKE	SALE	1.07	23.64K	25.29K	2.87M
Dec 12, 2025	EVNIN LUKE	SALE	1.08	17.86K	19.29K	2.89M
Dec 11, 2025	EVNIN LUKE	SALE	1.07	28.01K	29.97K	2.91M
Dec 10, 2025	EVNIN LUKE	SALE	1.06	37.1K	39.33K	2.94M
Dec 09, 2025	EVNIN LUKE	SALE	1.01	44.57K	45.02K	2.97M
Dec 08, 2025	EVNIN LUKE	SALE	0.99	34.04K	33.7K	3.02M
Dec 05, 2025	EVNIN LUKE	SALE	0.97	16.57K	16.07K	3.05M
Dec 04, 2025	EVNIN LUKE	SALE	0.97	53.42K	51.81K	3.07M
Dec 04, 2025	GADICKE ANSBERT	SALE	0.97	83.23K	80.73K	4.78M
Dec 04, 2025	MPM BIOVENTURES 2014, L.P.	SALE	0.97	83.23K	80.73K	4.78M
Dec 03, 2025	MPM BIOVENTURES 2014, L.P.	SALE	0.87	57.23K	49.79K	4.87M
Dec 03, 2025	EVNIN LUKE	SALE	0.87	36.73K	31.95K	3.12M
Dec 03, 2025	GADICKE ANSBERT	SALE	0.87	57.23K	49.79K	4.87M
Dec 02, 2025	EVNIN LUKE	SALE	0.89	38.04K	33.86K	3.16M
Dec 02, 2025	MPM BIOVENTURES 2014, L.P.	SALE	0.89	59.28K	52.76K	4.92M
Dec 02, 2025	GADICKE ANSBERT	SALE	0.89	59.28K	52.76K	4.92M
Dec 01, 2025	GADICKE ANSBERT	SALE	0.94	60.92K	57.26K	4.98M
Dec 01, 2025	MPM BIOVENTURES 2014, L.P.	SALE	0.94	60.92K	57.26K	4.98M
Dec 01, 2025	EVNIN LUKE	SALE	0.94	39.1K	36.75K	3.2M
Nov 28, 2025	MPM BIOVENTURES 2014, L.P.	SALE	0.99	20.28K	20.07K	5.04M
Nov 28, 2025	GADICKE ANSBERT	SALE	0.99	20.28K	20.07K	5.04M
Nov 28, 2025	EVNIN LUKE	SALE	0.99	13.01K	12.88K	3.24M
Nov 26, 2025	MPM BIOVENTURES 2014, L.P.	SALE	0.98	60.73K	59.52K	5.07M
Nov 26, 2025	GADICKE ANSBERT	SALE	0.98	60.73K	59.52K	5.07M
Nov 26, 2025	EVNIN LUKE	SALE	0.98	38.98K	38.2K	3.25M
Nov 25, 2025	EVNIN LUKE	SALE	0.92	27.3K	25.11K	3.29M
Nov 25, 2025	MPM BIOVENTURES 2014, L.P.	SALE	0.92	42.53K	39.13K	5.13M
Nov 25, 2025	GADICKE ANSBERT	SALE	0.92	42.53K	39.13K	5.13M
Nov 24, 2025	EVNIN LUKE	SALE	0.98	56.99K	55.85K	3.31M
Nov 24, 2025	GADICKE ANSBERT	SALE	0.98	88.8K	87.03K	5.17M
Nov 24, 2025	MPM BIOVENTURES 2014, L.P.	SALE	0.98	88.8K	87.03K	5.17M
Nov 21, 2025	MPM BIOVENTURES 2014, L.P.	SALE	0.83	64.33K	53.39K	5.26M
Nov 21, 2025	GADICKE ANSBERT	SALE	0.83	64.33K	53.39K	5.26M
Nov 21, 2025	EVNIN LUKE	SALE	0.83	41.29K	34.27K	3.37M
Nov 20, 2025	GADICKE ANSBERT	SALE	0.89	41.15K	36.63K	5.32M
Nov 20, 2025	MPM BIOVENTURES 2014, L.P.	SALE	0.89	41.15K	36.63K	5.32M
Nov 20, 2025	EVNIN LUKE	SALE	0.89	26.41K	23.51K	3.41M
Nov 19, 2025	GADICKE ANSBERT	SALE	0.94	66.32K	62.34K	5.36M
Nov 19, 2025	EVNIN LUKE	SALE	0.94	42.57K	40.01K	3.44M
Nov 19, 2025	MPM BIOVENTURES 2014, L.P.	SALE	0.94	66.32K	62.34K	5.36M
Nov 18, 2025	GADICKE ANSBERT	SALE	0.93	52.63K	48.94K	5.43M
Nov 18, 2025	MPM BIOVENTURES 2014, L.P.	SALE	0.93	52.63K	48.94K	5.43M
Nov 18, 2025	EVNIN LUKE	SALE	0.93	33.78K	31.41K	3.48M
Nov 17, 2025	GADICKE ANSBERT	SALE	0.95	57.06K	54.21K	5.48M
Nov 17, 2025	EVNIN LUKE	SALE	0.95	36.62K	34.79K	3.52M
Nov 17, 2025	MPM BIOVENTURES 2014, L.P.	SALE	0.95	57.06K	54.21K	5.48M
Nov 14, 2025	EVNIN LUKE	SALE	0.93	39.56K	36.79K	3.55M
Nov 14, 2025	GADICKE ANSBERT	SALE	0.93	61.64K	57.33K	5.54M
Nov 14, 2025	MPM BIOVENTURES 2014, L.P.	SALE	0.93	61.64K	57.33K	5.54M
Nov 13, 2025	MPM BIOVENTURES 2014, L.P.	SALE	0.98	90.95K	89.13K	5.6M
Nov 13, 2025	GADICKE ANSBERT	SALE	0.98	90.95K	89.13K	5.6M
Nov 13, 2025	EVNIN LUKE	SALE	0.98	58.37K	57.2K	3.59M
Nov 12, 2025	MPM BIOVENTURES 2014, L.P.	SALE	1.09	40.67K	44.33K	5.69M
Nov 12, 2025	GADICKE ANSBERT	SALE	1.09	40.67K	44.33K	5.69M
Nov 12, 2025	EVNIN LUKE	SALE	1.09	26.1K	28.45K	3.65M
Nov 11, 2025	MPM BIOVENTURES 2014, L.P.	SALE	1.14	55.81K	63.62K	5.73M
Nov 11, 2025	EVNIN LUKE	SALE	1.14	35.82K	40.83K	3.68M
Nov 11, 2025	GADICKE ANSBERT	SALE	1.14	55.81K	63.62K	5.73M
Nov 10, 2025	GADICKE ANSBERT	SALE	1.18	48.57K	57.31K	5.79M
Nov 10, 2025	EVNIN LUKE	SALE	1.18	31.17K	36.78K	3.71M
Nov 10, 2025	MPM BIOVENTURES 2014, L.P.	SALE	1.18	48.57K	57.31K	5.79M
Nov 07, 2025	MPM BIOVENTURES 2014, L.P.	SALE	1.11	68.48K	76.01K	5.84M
Nov 07, 2025	GADICKE ANSBERT	SALE	1.11	68.48K	76.01K	5.84M
Nov 07, 2025	EVNIN LUKE	SALE	1.11	43.95K	48.78K	3.74M
Nov 06, 2025	EVNIN LUKE	SALE	1.21	34.95K	42.29K	3.79M
Nov 06, 2025	MPM BIOVENTURES 2014, L.P.	SALE	1.21	54.45K	65.89K	5.9M
Nov 06, 2025	GADICKE ANSBERT	SALE	1.21	54.45K	65.89K	5.9M
Nov 05, 2025	EVNIN LUKE	SALE	1.22	30.77K	37.54K	3.82M
Nov 05, 2025	GADICKE ANSBERT	SALE	1.22	47.95K	58.5K	5.96M
Nov 05, 2025	MPM BIOVENTURES 2014, L.P.	SALE	1.22	47.95K	58.5K	5.96M
Nov 04, 2025	MPM BIOVENTURES 2014, L.P.	SALE	1.22	140.49K	171.4K	6.01M
Nov 04, 2025	GADICKE ANSBERT	SALE	1.22	140.49K	171.4K	6.01M
Nov 04, 2025	EVNIN LUKE	SALE	1.22	90.16K	110K	3.85M
Nov 03, 2025	GADICKE ANSBERT	SALE	1.29	94.06K	121.34K	6.15M
Nov 03, 2025	MPM BIOVENTURES 2014, L.P.	SALE	1.29	94.06K	121.34K	6.15M
Nov 03, 2025	EVNIN LUKE	SALE	1.29	60.37K	77.88K	3.94M
Oct 31, 2025	GADICKE ANSBERT	SALE	1.28	114.04K	145.98K	6.24M
Oct 31, 2025	EVNIN LUKE	SALE	1.28	73.19K	93.69K	4M
Oct 31, 2025	MPM BIOVENTURES 2014, L.P.	SALE	1.28	114.04K	145.98K	6.24M
Oct 30, 2025	GADICKE ANSBERT	SALE	1.43	86.94K	124.32K	6.36M
Oct 30, 2025	MPM BIOVENTURES 2014, L.P.	SALE	1.43	86.94K	124.32K	6.36M
Oct 30, 2025	EVNIN LUKE	SALE	1.43	55.8K	79.79K	4.08M
Oct 29, 2025	GADICKE ANSBERT	SALE	1.55	134.24K	208.07K	6.44M
Oct 29, 2025	MPM BIOVENTURES 2014, L.P.	SALE	1.55	134.24K	208.07K	6.44M
Oct 29, 2025	EVNIN LUKE	SALE	1.55	86.15K	133.54K	4.13M
Oct 28, 2025	EVNIN LUKE	SALE	1.64	44.33K	72.7K	4.22M
Oct 28, 2025	GADICKE ANSBERT	SALE	1.64	69.07K	113.27K	6.58M
Oct 28, 2025	MPM BIOVENTURES 2014, L.P.	SALE	1.64	69.07K	113.27K	6.58M
Oct 27, 2025	MPM BIOVENTURES 2014, L.P.	SALE	1.72	72.71K	125.06K	6.65M
Oct 27, 2025	GADICKE ANSBERT	SALE	1.72	72.71K	125.06K	6.65M
Oct 27, 2025	EVNIN LUKE	SALE	1.72	46.66K	80.26K	4.26M
May 14, 2025	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	0.98	162.54K	159.29K	6.24M
May 13, 2025	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	0.98	52.97K	51.91K	6.07M
May 12, 2025	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	0.86	320.91K	275.99K	6.02M
Mar 27, 2025	MPM BIOVENTURES 2014, L.P.	SALE	1.05	1.96K	2.06K	3.21M
Mar 27, 2025	GADICKE ANSBERT	SALE	1.05	4.39K	4.61K	6.72M
Mar 27, 2025	EVNIN LUKE	SALE	1.05	2.43K	2.55K	4.31M
Jan 06, 2023	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	2.21	1.85M	4.1M	5.7M
Dec 15, 2021	LEONARD REID	SALE	13.97	135	1.89K	122.16K
Jun 16, 2021	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	13.37	9.29K	124.14K	4.29M
Jun 15, 2021	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	12.95	7.96K	103.06K	4.28M
Jun 14, 2021	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	12.75	306.06K	3.9M	4.27M
May 04, 2021	MPM BIOVENTURES 2014, L.P.	PURCHASE	16.00	125.76K	2.01M	3.19M
May 04, 2021	LONGWOOD FUND III GP, LLC	PURCHASE	16.00	250K	4M	1.68M
May 04, 2021	TAIHO VENTURES LLC	PURCHASE	16.00	312.5K	5M	2.07M
May 04, 2021	SPHERA GLOBAL HEALTHCARE MANAGEMENT LP	PURCHASE	16.00	475K	7.6M	788K
May 04, 2021	GADICKE ANSBERT	PURCHASE	16.00	245K	3.92M	6.67M
May 04, 2021	ARKIN BIO VENTURES 2 L.P.	PURCHASE	16.00	400K	6.4M	2.05M
May 04, 2021	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	16.00	105.79K	1.69M	443.83K
May 04, 2021	LAZARUS ALON	PURCHASE	16.00	400K	6.4M	2.05M
May 04, 2021	EVNIN LUKE	PURCHASE	16.00	150.8K	2.41M	4.28M
May 04, 2021	ASANUMA SAKAE	PURCHASE	16.00	312.5K	5M	2.07M
May 04, 2021	FLYNN JAMES E	PURCHASE	16.00	800K	12.8M	2.55M
Dec 23, 2020	EVNIN LUKE	PURCHASE	0.00	7.94M	-	7.94M
Dec 23, 2020	LAZARUS ALON	PURCHASE	0.00	3.56M	-	3.56M
Dec 23, 2020	ASANUMA SAKAE	PURCHASE	0.00	3.8M	-	3.8M

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES5.78M104

NET SHARES-5.78M104

SHARES HELD469.93M104

% NET SHARES-101.23%0%

Frequently Asked Questions