How many institutions own GPCR stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own GPCR shares is 240, representing 98.22% of the company's common stock.

Who are the major shareholders selling Structure Therapeutics Inc. stock?

IKARIAN CAPITAL, LLC, in the last quarter, reduced its stake in GPCR by -10.84% restricting it's holding to 163.24 thousand shares of worth nearly $4.57M. CCG WEALTH MANAGEMENT, LLC also lessened -93.33% of the GPCR shares from its portfolio, reducing its holding to 10 thousand shares of worth $280.00K. CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD. also shunned GPCR shares holding by -12.73% last quarter which brought its holding to 10.44 thousand shares worth $292.43K.

Investors who are buying GPCR stock?

As per its latest 13F filing, GSA CAPITAL PARTNERS LLP increased its stake in GPCR by 100% in the last quarter. The institutional holder raised its holding to 9.89 thousand shares having worth more than $277.00K. ENVESTNET ASSET MANAGEMENT INC also added 14.46% more shares of GPCR to its portfolio, raising its holding to 12.22 thousand shares of worth $342.16K. DNB ASSET MANAGEMENT AS also increased its GPCR shares holding by 21.18% which brought its holding to 12.89 thousand shares worth $360.86K.

GPCR's major insiders: who are they?

The insider with the most stakes in GPCR is Farid Ramy , director at the company. Additionally, GPCR stock is highly held by CHIEF EXECUTIVE OFFICER Stevens Raymond C and CHIEF SCIENTIFIC OFFICER Lin Xichen among others.

Did an insider recently sell GPCR stock?

Company executives, directors, and other insiders own 3.04% percent of Structure Therapeutics Inc.'s stock. Within the last six months, there have been 2 transaction(s) in which GPCR insiders have sold stock, totaling 41.85K shares. Insiders that have sold shares include FMR LLC, STEVENS RAYMOND C, and LIN XICHEN.

Which insider recently purchased GPCR stock?

There have been 0 transaction(s) during the past 6-months in which Structure Therapeutics Inc. insiders have bought stock, totalling 0 shares

How much of GPCR does insiders own?

Around 1.52M Structure Therapeutics Inc. shares are held by insiders, which represents about 3.04% of GPCR stock.

Who is the insider with the largest stake?

GPCR director, Farid Ramy holds the largest portfolio of the company's shares. GPCR shares owned by Farid total nearly 275 thousand.

Which institution holds the most shares in GPCR?

GSA CAPITAL PARTNERS LLP is the largest institutional owner in GPCR which holds 9.89 thousand shares worth $277.00K or 0.05% of the total GPCR shares outstanding followed by IKARIAN CAPITAL, LLC with ownership of 163.24 thousand shares representing 0.85% of the GPCR ownership. CCG WEALTH MANAGEMENT, LLC is the third largest stakeholder with 10 thousand shares or 0.05% of the ownership worth more than $280.00K.

Is Structure Therapeutics Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the GPCR is concerned, it is a stock which is optionable.

Is there a short position on GPCR's shares?

Number of GPCR shares short is 7.19M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding GPCR shares are there?

As of today, 57.60M shares of GPCR are outstanding.

Is there many float in GPCR stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, GPCR has 133.55M shares in float.

GPCR short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for GPCR is 10.2.

Structure Therapeutics (GPCR) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares12.49

Short Percent Of Float18.01

Shares Outstanding57.60M

Shares Float133.55M

Shares Short7.19M

Short Ratio10.2

18.01%

Short % of Float

12.49%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

3.04% Percentage of Shares held by All Insiders

98.22% Percentage of Shares held by All Institutions

101.3% Percentage of Float held by Institutions

240

Number of Institutions Holding Shares

Institutional Ownership

About 98.22% of GPCR shares are held by financial institutions. GSA CAPITAL PARTNERS LLP is the top corporate investor, holding 9.89K shares valued at $277.00K. A 0.05% stake in Structure Therapeutics Inc. is owned by the company. IKARIAN CAPITAL, LLC owns 163.24K shares valued at $4.57M, which translates its holding of 0.85% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	GSA CAPITAL PARTNERS LLP	0.05%	9.89K	277K	9.89K	+100.00%
Sep 30, 2025	IKARIAN CAPITAL, LLC	0.85%	163.24K	4.57M	-19.85K	-10.84%
Sep 30, 2025	CCG WEALTH MANAGEMENT, LLC	0.05%	10K	280K	-140K	-93.33%
Sep 30, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.05%	10.44K	292.43K	-1.52K	-12.73%
Sep 30, 2025	TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY	0.06%	10.75K	301K	-6.9K	-39.09%
Sep 30, 2025	ENVESTNET ASSET MANAGEMENT INC	0.06%	12.22K	342.16K	1.54K	+14.46%
Sep 30, 2025	DNB ASSET MANAGEMENT AS	0.07%	12.89K	360.86K	2.25K	+21.18%
Sep 30, 2025	JANNEY CAPITAL MANAGEMENT LLC	0.07%	13.72K	384K	13.72K	+100.00%
Sep 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.08%	15.71K	439.99K	3.8K	+31.90%
Sep 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.09%	16.43K	459.9K	-14.23K	-46.42%
Sep 30, 2025	EVERSEPT PARTNERS, LP	0.87%	166.39K	4.66M	67.05K	+67.50%
Sep 30, 2025	JPMORGAN CHASE & CO	0.3%	58.15K	1.63M	15.71K	+37.01%
Sep 30, 2025	HANDELSBANKEN FONDER AB	0.88%	168K	4.7M	-212K	-55.79%
Sep 30, 2025	LPL FINANCIAL LLC	0.12%	23K	644.08K	11.4K	+98.32%
Sep 30, 2025	SIMPLEX TRADING, LLC	0.13%	25.16K	704K	2.07K	+8.95%
Sep 30, 2025	NOMURA ASSET MANAGEMENT CO LTD	0.13%	25.86K	723.97K	982	+3.95%
Sep 30, 2025	HEADLANDS TECHNOLOGIES LLC	0.14%	26.81K	750.79K	4.48K	+20.04%
Sep 30, 2025	ALPS ADVISORS INC	0.15%	27.96K	782.82K	-3.12K	-10.02%
Sep 30, 2025	TRUEMARK INVESTMENTS, LLC	0.18%	34.86K	976.11K	-2.9K	-7.69%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.19%	36.09K	1.01M	-7.6K	-17.40%
Sep 30, 2025	SG AMERICAS SECURITIES, LLC	0.21%	39.7K	1.11M	20.46K	+106.35%
Sep 30, 2025	QUINN OPPORTUNITY PARTNERS LLC	0.22%	42K	1.18M	0	0
Sep 30, 2025	MONASHEE INVESTMENT MANAGEMENT LLC	0.34%	200K	5.6M	-230K	-53.49%
Sep 30, 2025	PRIVATE CAPITAL ADVISORS, INC.	0.29%	55.19K	1.55M	55.19K	+100.00%
Sep 30, 2025	DLD ASSET MANAGEMENT, LP	0.13%	25K	700K	25K	+100.00%
Sep 30, 2025	JANUS HENDERSON GROUP PLC	7.61%	4.45M	124.6M	-124.18K	-2.72%
Sep 30, 2025	ARROWMARK COLORADO HOLDINGS LLC	0.55%	323.17K	9.05M	24.23K	+8.11%
Sep 30, 2025	PIER CAPITAL, LLC	0.34%	197.51K	5.53M	-969	-0.49%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.3%	57.96K	1.62M	3.78K	+6.97%
Sep 30, 2025	MACQUARIE GROUP LTD	0.3%	58K	1.62M	0	0
Sep 30, 2025	FMR LLC	8.98%	5.25M	147.01M	335.4K	+6.82%
Sep 30, 2025	BVF INC/IL	5.48%	3.2M	89.71M	1.43M	+80.87%
Sep 30, 2025	BAKER BROS. ADVISORS LP	2.66%	1.56M	43.57M	-952.66K	-37.97%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	2.18%	1.27M	35.69M	54.5K	+4.47%
Sep 30, 2025	ORBIMED ADVISORS LLC	1.95%	1.14M	31.9M	-60K	-5.00%
Sep 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	1.82%	1.06M	29.76M	0	0
Sep 30, 2025	SIREN, L.L.C.	1.76%	1.03M	28.75M	1.03M	+100.00%
Sep 30, 2025	LOGOS GLOBAL MANAGEMENT LP	1.45%	850K	23.8M	0	0
Sep 30, 2025	PRINCIPAL FINANCIAL GROUP INC	1.35%	787.48K	22.05M	-65.72K	-7.70%
Sep 30, 2025	ABRDN PLC	1%	586.87K	16.43M	185.25K	+46.12%
Sep 30, 2025	MORGAN STANLEY	0.99%	577.74K	16.18M	-339.61K	-37.02%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	0.86%	504.4K	14.12M	284.22K	+129.09%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.83%	486.79K	13.63M	-4.41K	-0.90%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.79%	461.55K	12.92M	461.55K	+100.00%
Sep 30, 2025	CITADEL ADVISORS LLC	0.76%	443.8K	12.43M	-884.68K	-66.59%
Sep 30, 2025	AVORO CAPITAL ADVISORS LLC	0.43%	250K	2.24M	250K	+100.00%
Sep 30, 2025	READYSTATE ASSET MANAGEMENT LP	0.41%	237.19K	6.64M	58.58K	+32.80%
Sep 30, 2025	JEFFERIES FINANCIAL GROUP INC.	0.89%	170.35K	4.77M	170.35K	+100.00%
Sep 30, 2025	SPHERA FUNDS MANAGEMENT LTD.	0.91%	173.93K	4.87M	78K	+81.31%
Sep 30, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.94%	180.1K	5.04M	45K	+33.31%
Sep 30, 2025	INVESCO LTD.	0.76%	443.74K	12.42M	19.19K	+4.52%
Sep 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.7%	407.7K	11.42M	77.7K	+23.55%
Sep 30, 2025	FIRST LIGHT ASSET MANAGEMENT, LLC	0.34%	197.35K	5.53M	75.12K	+61.46%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.8%	153.9K	4.31M	42K	+37.53%
Sep 30, 2025	PLATINUM INVESTMENT MANAGEMENT LTD	0.64%	122.76K	3.44M	47.86K	+63.90%
Sep 30, 2025	JUMP FINANCIAL, LLC	0.55%	106.4K	2.98M	43.17K	+68.26%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.47%	90.43K	2.53M	24.6K	+37.36%
Sep 30, 2025	BIRCHVIEW CAPITAL, LP	0.41%	78K	2.18M	42K	+116.67%
Sep 30, 2025	BANQUE PICTET & CIE SA	0.33%	64.19K	1.8M	-6.22K	-8.83%
Sep 30, 2025	BANK OF MONTREAL /CAN/	0.32%	60.72K	1.7M	2.65K	+4.56%
Sep 30, 2025	EXCHANGE TRADED CONCEPTS, LLC	0.3%	58.22K	1.63M	-3.51K	-5.69%
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.95%	182.91K	5.12M	182.91K	+100.00%
Sep 30, 2025	CAPTION MANAGEMENT, LLC	0.83%	159.4K	4.46M	97.5K	+157.51%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	9.73%	5.69M	159.3M	-1.19M	-17.26%
Sep 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	1.49%	873.5K	24.46M	200.71K	+29.83%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.37%	213.61K	5.98M	137.81K	+181.80%
Sep 30, 2025	UBS GROUP AG	0.36%	208.09K	5.83M	55.11K	+36.02%
Sep 30, 2025	SECTORAL ASSET MANAGEMENT INC	0.38%	221.87K	6.21M	170.5K	+331.92%
Sep 30, 2025	HIGHVISTA STRATEGIES LLC	0.4%	236.24K	6.61M	149.62K	+172.72%
Sep 30, 2025	BLACKROCK, INC.	0.45%	263.94K	7.39M	20.6K	+8.47%
Sep 30, 2025	SC CHINA HOLDING LTD	0.45%	266.06K	4.61M	0	0
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.49%	289.39K	8.1M	-63.48K	-17.99%
Sep 30, 2025	BELLEVUE GROUP AG	0.54%	315.86K	8.84M	-32.67K	-9.37%
Sep 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	0.63%	368.55K	10.32M	200K	+118.66%
Sep 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	0.64%	372.87K	10.44M	372.87K	+100.00%
Sep 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.64%	373.41K	10.46M	0	0
Sep 30, 2025	FRANKLIN RESOURCES INC	1.28%	745.73K	20.88M	3.95K	+0.53%
Sep 30, 2025	CASDIN CAPITAL, LLC	2.66%	1.56M	43.54M	330K	+26.94%
Sep 30, 2025	TWO SIGMA ADVISERS, LP	0.43%	249.3K	6.98M	213.2K	+590.58%
Sep 30, 2025	STEMPOINT CAPITAL LP	0.67%	129.34K	3.62M	129.34K	+100.00%
Sep 30, 2025	DEEP TRACK CAPITAL, LP	7.21%	4.22M	118.04M	-918.11K	-17.88%
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	2.59%	1.52M	42.49M	0	0
Sep 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	1.63%	951.15K	26.63M	-184.73K	-16.26%
Sep 30, 2025	PACIFIC HEIGHTS ASSET MANAGEMENT LLC	1.2%	700K	19.6M	240K	+52.17%
Sep 30, 2025	CATALIO CAPITAL MANAGEMENT, LP	1.11%	651.81K	18.25M	-18.77K	-2.80%
Sep 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.42%	244.85K	6.86M	244.85K	+100.00%
Sep 30, 2025	AMERIPRISE FINANCIAL INC	2.09%	1.22M	34.28M	-364.05K	-22.92%
Sep 30, 2025	NATIONAL BANK OF CANADA /FI/	0.75%	144K	4.03M	143.8K	+71,900.00%
Sep 30, 2025	MISSION WEALTH MANAGEMENT, LP	0.05%	9.58K	268.32K	9.58K	+100.00%
Jun 30, 2025	ABRDN PLC	0.7%	401.62K	8.33M	152.73K	+61.36%
Jun 30, 2025	JANUS HENDERSON GROUP PLC	7.95%	4.57M	94.95M	217.81K	+5.00%
Jun 30, 2025	EVERSEPT PARTNERS, LP	0.17%	99.34K	2.06M	99.34K	+100.00%
Jun 30, 2025	AMERIPRISE FINANCIAL INC	2.76%	1.59M	32.94M	106.39K	+7.18%
Jun 30, 2025		1.17%	670.58K	13.91M	-34.29K	-4.86%
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.57%	330K	6.84M	100.57K	+43.83%
Jun 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	1.85%	1.06M	22.05M	0	0
Jun 30, 2025	UBS GROUP AG	0.27%	152.98K	3.17M	-85.22K	-35.78%
Jun 30, 2025	CCG WEALTH MANAGEMENT, LLC	0.26%	150K	3.11M	0	0
Jun 30, 2025	FEDERATED HERMES, INC.	0.81%	468.3K	9.71M	-702.65K	-60.01%
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	2.64%	1.52M	31.47M	0	0
Jun 30, 2025	CASDIN CAPITAL, LLC	2.13%	1.23M	25.41M	525K	+75.00%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	2.12%	1.22M	25.3M	429.9K	+54.41%
Jun 30, 2025	ORBIMED ADVISORS LLC	2.08%	1.2M	24.87M	547.27K	+83.93%
Jun 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	1.97%	1.14M	23.56M	2.9K	+0.26%
Jun 30, 2025	INVESCO LTD.	0.74%	424.55K	8.81M	30.16K	+7.65%
Jun 30, 2025	SC CHINA HOLDING LTD	0.46%	266.06K	5.52M	0	0
Jun 30, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.31%	175.64K	3.64M	-12.43K	-6.61%
Jun 30, 2025	CANADA PENSION PLAN INVESTMENT BOARD	0.29%	167.8K	3.48M	167.8K	+100.00%
Jun 30, 2025	FRANKLIN RESOURCES INC	1.29%	741.78K	15.38M	1.63K	+0.22%
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.56%	321.59K	6.67M	321.59K	+100.00%
Jun 30, 2025	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.24%	139.72K	2.9M	-18.24K	-11.55%
Jun 30, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.23%	135.1K	2.8M	65.1K	+93.00%
Jun 30, 2025	FIRST LIGHT ASSET MANAGEMENT, LLC	0.21%	122.23K	2.53M	-10.15K	-7.67%
Jun 30, 2025	POINT72 EUROPE (LONDON) LLP	0.2%	116.7K	2.42M	26K	+28.67%
Jun 30, 2025	SPHERA FUNDS MANAGEMENT LTD.	0.17%	95.93K	1.99M	11.93K	+14.20%
Jun 30, 2025	HIGHVISTA STRATEGIES LLC	0.15%	86.62K	1.8M	69.06K	+393.26%
Jun 30, 2025	TREXQUANT INVESTMENT LP	0.14%	81.59K	1.69M	-38.75K	-32.20%
Jun 30, 2025	PLATINUM INVESTMENT MANAGEMENT LTD	0.13%	74.9K	1.55M	0	0
Jun 30, 2025	VERITION FUND MANAGEMENT LLC	0.13%	72.98K	1.51M	53.4K	+272.71%
Jun 30, 2025	BANQUE PICTET & CIE SA	0.12%	70.4K	1.46M	-11.37K	-13.90%
Jun 30, 2025	CITADEL ADVISORS LLC	2.31%	1.33M	27.55M	336.14K	+33.87%
Jun 30, 2025	LOGOS GLOBAL MANAGEMENT LP	1.48%	850K	17.63M	425K	+100.00%
Jun 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	1.17%	672.79K	13.95M	-599.95K	-47.14%
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	0.85%	491.19K	10.19M	-19.01K	-3.73%
Jun 30, 2025	PACIFIC HEIGHTS ASSET MANAGEMENT LLC	0.8%	460K	9.54M	460K	+100.00%
Jun 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.65%	373.41K	7.74M	0	0
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.61%	352.87K	7.32M	-424.31K	-54.60%
Jun 30, 2025	BELLEVUE GROUP AG	0.61%	348.53K	7.23M	126.81K	+57.20%
Jun 30, 2025	ARROWMARK COLORADO HOLDINGS LLC	0.52%	298.94K	6.2M	53.75K	+21.92%
Jun 30, 2025	BLACKROCK, INC.	0.42%	243.33K	5.05M	-323.17K	-57.05%
Jun 30, 2025	VESTAL POINT CAPITAL, LP	2.09%	1.2M	24.89M	-588.99K	-32.92%
Jun 30, 2025	MORGAN STANLEY	1.59%	917.35K	19.03M	224.91K	+32.48%
Jun 30, 2025	MONASHEE INVESTMENT MANAGEMENT LLC	0.75%	430K	8.92M	137.14K	+46.83%
Jun 30, 2025	HANDELSBANKEN FONDER AB	0.66%	380K	7.88M	0	0
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.38%	220.17K	4.57M	-104.26K	-32.14%
Jun 30, 2025	FORESITE CAPITAL MANAGEMENT VI LLC	0.36%	210K	4.36M	-210K	-50.00%
Jun 30, 2025	PIER CAPITAL, LLC	0.34%	198.48K	4.12M	-14.04K	-6.61%
Jun 30, 2025	IKARIAN CAPITAL, LLC	0.32%	183.09K	3.8M	-81K	-30.67%
Jun 30, 2025	WOODLINE PARTNERS LP	0.31%	176.45K	3.66M	1.03K	+0.59%
Jun 30, 2025	MARSHALL WACE, LLP	0.31%	176.06K	3.65M	145.43K	+474.87%
Jun 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	0.26%	150K	3.11M	0	0
Jun 30, 2025	DEEP TRACK CAPITAL, LP	8.92%	5.13M	106.48M	1.03M	+25.22%
Jun 30, 2025	FMR LLC	8.54%	4.91M	101.94M	-968.74K	-16.46%
Jun 30, 2025	PRINCIPAL FINANCIAL GROUP INC	1.48%	853.2K	17.7M	96.5K	+12.75%
Jun 30, 2025	READYSTATE ASSET MANAGEMENT LP	0.31%	178.61K	3.7M	-302.63K	-62.89%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	11.95%	6.88M	142.6M	-915.41K	-11.75%
Jun 30, 2025	CATALIO CAPITAL MANAGEMENT, LP	1.17%	670.58K	13.91M	-34.29K	-4.86%
Jun 30, 2025	BAKER BROS. ADVISORS LP	4.36%	2.51M	52.03M	2.15M	+593.86%
Jun 30, 2025	BVF INC/IL	3.08%	1.77M	36.74M	0	0
Jun 30, 2025	CAPITAL INTERNATIONAL INVESTORS	2.81%	1.62M	33.58M	-150	-0.01%
Mar 31, 2025	DEEP TRACK CAPITAL, LP	0.72%	4.1M	70.97M	1.3M	+46.43%
Mar 31, 2025	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.03%	157.96K	2.73M	157.96K	+100.00%
Mar 31, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	0.03%	168.55K	2.92M	-52.45K	-23.73%
Mar 31, 2025	WOODLINE PARTNERS LP	0.03%	175.42K	3.04M	-158.48K	-47.46%
Mar 31, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.03%	188.07K	3.26M	35.67K	+23.41%
Mar 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.04%	202.48K	3.5M	202.48K	+100.00%
Mar 31, 2025	AMERICAN CENTURY COMPANIES INC	0.09%	510.2K	8.83M	-102.42K	-16.72%
Mar 31, 2025	BLACKROCK, INC.	0.1%	566.51K	9.81M	-44.08K	-7.22%
Mar 31, 2025	ORBIMED ADVISORS LLC	0.11%	652.03K	11.29M	0	0
Mar 31, 2025	MORGAN STANLEY	0.12%	692.44K	11.99M	305.26K	+78.84%
Mar 31, 2025	CASDIN CAPITAL, LLC	0.12%	700K	12.12M	0	0
Mar 31, 2025		0.12%	704.86K	12.2M	135.47K	+23.79%
Mar 31, 2025	FRANKLIN RESOURCES INC	0.13%	740.15K	12.81M	2.06K	+0.28%
Mar 31, 2025	PRINCIPAL FINANCIAL GROUP INC	0.13%	756.71K	13.1M	-34.43K	-4.35%
Mar 31, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.2%	1.13M	19.61M	52.02K	+4.81%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.14%	790.16K	13.68M	39.15K	+5.21%
Mar 31, 2025	JANUS HENDERSON GROUP PLC	0.76%	4.36M	86.13M	195.31K	+4.70%
Mar 31, 2025	FIL LTD	0.2%	1.15M	19.91M	-149.58K	-11.51%
Mar 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.22%	1.27M	22.03M	-784.67K	-38.14%
Mar 31, 2025	AMERIPRISE FINANCIAL INC	0.26%	1.48M	25.65M	61.76K	+4.35%
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	0.26%	1.52M	26.27M	0	0
Mar 31, 2025	FMR LLC	1.03%	5.88M	101.85M	-195.04K	-3.21%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	1.36%	7.79M	134.87M	5.57K	+0.07%
Mar 31, 2025	BAKER BROS. ADVISORS LP	0.06%	361.57K	6.26M	0	0
Mar 31, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.07%	373.41K	6.46M	0	0
Mar 31, 2025	HANDELSBANKEN FONDER AB	0.07%	380K	6.58M	215K	+130.30%
Mar 31, 2025	INVESCO LTD.	0.07%	394.39K	6.83M	22.62K	+6.08%
Mar 31, 2025	CITADEL ADVISORS LLC	0.17%	992.34K	17.18M	-487K	-32.92%
Mar 31, 2025	FEDERATED HERMES, INC.	0.2%	1.17M	20.27M	-875.01K	-42.77%
Mar 31, 2025	CAPITAL INTERNATIONAL INVESTORS	0.28%	1.62M	28.03M	-55	0.00%
Mar 31, 2025	BVF INC/IL	0.31%	1.77M	30.66M	0	0
Mar 31, 2025	VESTAL POINT CAPITAL, LP	0.31%	1.79M	30.97M	63.99K	+3.71%
Mar 31, 2025	CANDRIAM S.C.A.	0.04%	214.06K	3.71M	-1.36K	-0.63%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.14%	777.17K	13.45M	-617.13K	-44.26%
Mar 31, 2025	PIER CAPITAL, LLC	0.04%	212.52K	3.68M	79.92K	+60.27%
Mar 31, 2025	BELLEVUE GROUP AG	0.04%	221.72K	3.84M	-263.34K	-54.29%
Mar 31, 2025	UBS GROUP AG	0.04%	238.2K	4.12M	-5.87K	-2.40%
Mar 31, 2025	ARROWMARK COLORADO HOLDINGS LLC	0.04%	245.19K	4.24M	12.28K	+5.27%
Mar 31, 2025	MONASHEE INVESTMENT MANAGEMENT LLC	0.05%	292.86K	5.07M	160.86K	+121.87%
Mar 31, 2025	FORESITE CAPITAL MANAGEMENT VI LLC	0.07%	420K	7.27M	0	0
Mar 31, 2025	ABRDN PLC	0.04%	248.9K	4.31M	77.51K	+45.23%
Mar 31, 2025	IKARIAN CAPITAL, LLC	0.05%	264.09K	4.57M	-20K	-7.04%
Mar 31, 2025	SC CHINA HOLDING LTD	0.05%	266.06K	6.2M	0	0
Mar 31, 2025	LOGOS GLOBAL MANAGEMENT LP	0.07%	425K	7.36M	-275K	-39.29%
Mar 31, 2025	CAPITAL RESEARCH GLOBAL INVESTORS	0.38%	2.16M	37.46M	-1.37M	-38.82%
Mar 31, 2025	CAMBER CAPITAL MANAGEMENT LP	0.05%	300K	5.19M	0	0
Mar 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.04%	229.43K	3.97M	-247.27K	-51.87%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.06%	324.44K	5.62M	-258.43K	-44.34%
Mar 31, 2025	READYSTATE ASSET MANAGEMENT LP	0.08%	481.24K	8.33M	271.9K	+129.88%
Mar 31, 2025	TCG CROSSOVER MANAGEMENT, LLC	0.19%	1.06M	18.4M	0	0

Insiders

Among the GPCR insiders holding of 3.04% of the stake in company, FARID RAMY, director, holds the largest shares of 275K. STEVENS RAYMOND C, CHIEF EXECUTIVE OFFICER, is the second largest GPCR insider with ownership of 0 shares. LIN XICHEN, CHIEF SCIENTIFIC OFFICER, stands third with possession of 0 shares of that stake.

Insiders	Designation	Shares Held
FARID RAMY	director	275K
STEVENS RAYMOND C	CHIEF EXECUTIVE OFFICER	0
LIN XICHEN	CHIEF SCIENTIFIC OFFICER	0
FMR LLC	See Remark 1	0

Buying/Selling by Insiders

Date	Insider	Type	Shares	Value ($)	Shares Total
Dec 08, 2025	FMR LLC	SALE	15.54K	-	0
Jul 30, 2025	FMR LLC	SALE	26.31K	-	1.52M
Feb 06, 2025	FMR LLC	SALE	41	-	0
Jun 10, 2024	STEVENS RAYMOND C	SALE	185K	-	0
Jun 03, 2024	LIN XICHEN	SALE	17.7K	-	0
Mar 14, 2024	FMR LLC	SALE	22K	-	1.54M
Feb 13, 2024	FMR LLC	SALE	525	-	1.56M
Dec 05, 2023	FMR LLC	SALE	1.37K	-	2.73K
Oct 18, 2023	FMR LLC	SALE	1.37K	-	4.1K
Feb 07, 2023	FARID RAMY	PURCHASE	275K	-	275K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES41.85K2

NET SHARES-41.85K2

SHARES HELD1.52M2

% NET SHARES-102.76%0%

Frequently Asked Questions