How many institutions own FULC stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own FULC shares is 161, representing 101.55% of the company's common stock.

Who are the major shareholders selling Fulcrum Therapeutics, Inc. stock?

MARTINGALE ASSET MANAGEMENT L P, in the last quarter, reduced its stake in FULC by -88.39% restricting it's holding to 10.56 thousand shares of worth nearly $97.18M. SIMPLEX TRADING, LLC also lessened -88.3% of the FULC shares from its portfolio, reducing its holding to 12.8 thousand shares of worth $117.00K. LEGAL & GENERAL GROUP PLC also shunned FULC shares holding by -6.23% last quarter which brought its holding to 16.37 thousand shares worth $150.63K.

Investors who are buying FULC stock?

As per its latest 13F filing, HSBC HOLDINGS PLC increased its stake in FULC by 8.62% in the last quarter. The institutional holder raised its holding to 53.81 thousand shares having worth more than $474.03K. ASSETMARK, INC also added 100% more shares of FULC to its portfolio, raising its holding to 9.61 thousand shares of worth $88.42K. Y-INTERCEPT (HONG KONG) LTD also increased its FULC shares holding by 100% which brought its holding to 11.27 thousand shares worth $103.70K.

FULC's major insiders: who are they?

The insider with the most stakes in FULC is RA CAPITAL MANAGEMENT, L.P. , 10 percent owner at the company. Additionally, FULC stock is highly held by LEVIN MARK J and 10 percent owner Third Rock Ventures III, L.P. among others.

Did an insider recently sell FULC stock?

Company executives, directors, and other insiders own 1.82% percent of Fulcrum Therapeutics, Inc.'s stock. Within the last six months, there have been 4 transaction(s) in which FULC insiders have sold stock, totaling 125.17K shares. Insiders that have sold shares include GOULD ROBERT J, OLTMANS CURTIS GALE, and RA CAPITAL MANAGEMENT, L.P..

Which insider recently purchased FULC stock?

There have been 0 transaction(s) during the past 6-months in which Fulcrum Therapeutics, Inc. insiders have bought stock, totalling 0 shares

How much of FULC does insiders own?

Around 7.02M Fulcrum Therapeutics, Inc. shares are held by insiders, which represents about 1.82% of FULC stock.

Who is the insider with the largest stake?

FULC 10 percent owner, RA CAPITAL MANAGEMENT, L.P. holds the largest portfolio of the company's shares. FULC shares owned by RA total nearly 6.05 million.

Which institution holds the most shares in FULC?

HSBC HOLDINGS PLC is the largest institutional owner in FULC which holds 53.81 thousand shares worth $474.03K or 0.09% of the total FULC shares outstanding followed by ASSETMARK, INC with ownership of 9.61 thousand shares representing 0.02% of the FULC ownership. MARTINGALE ASSET MANAGEMENT L P is the third largest stakeholder with 10.56 thousand shares or 0.02% of the ownership worth more than $97.18M.

Is Fulcrum Therapeutics, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the FULC is concerned, it is a stock which is optionable.

Is there a short position on FULC's shares?

Number of FULC shares short is 5.02M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding FULC shares are there?

As of today, 54.09M shares of FULC are outstanding.

Is there many float in FULC stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, FULC has 14.59M shares in float.

FULC short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for FULC is 5.37.

Fulcrum Therapeutics (FULC) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares9.28

Short Percent Of Float13.4

Shares Outstanding54.09M

Shares Float14.59M

Shares Short5.02M

Short Ratio5.37

13.4%

Short % of Float

9.28%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

1.82% Percentage of Shares held by All Insiders

101.55% Percentage of Shares held by All Institutions

103.43% Percentage of Float held by Institutions

161

Number of Institutions Holding Shares

Institutional Ownership

About 101.55% of FULC shares are held by financial institutions. HSBC HOLDINGS PLC is the top corporate investor, holding 53.81K shares valued at $474.03K. A 0.09% stake in Fulcrum Therapeutics, Inc. is owned by the company. ASSETMARK, INC owns 9.61K shares valued at $88.42K, which translates its holding of 0.02% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	HSBC HOLDINGS PLC	0.09%	53.81K	474.03K	4.27K	+8.62%
Sep 30, 2025	ASSETMARK, INC	0.02%	9.61K	88.42K	9.61K	+100.00%
Sep 30, 2025	MARTINGALE ASSET MANAGEMENT L P	0.02%	10.56K	97.18M	-80.45K	-88.39%
Sep 30, 2025	Y-INTERCEPT (HONG KONG) LTD	0.02%	11.27K	103.7K	11.27K	+100.00%
Sep 30, 2025	SIMPLEX TRADING, LLC	0.02%	12.8K	117K	-96.57K	-88.30%
Sep 30, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.02%	12.84K	118.16K	368	+2.95%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.02%	13.1K	120.52K	0	0
Sep 30, 2025	ALPHABET INC.	0.02%	14.26K	131.21K	0	0
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.02%	14.27K	131.32K	8.28K	+137.94%
Sep 30, 2025	WINTON GROUP LTD	0.03%	16.21K	149.15K	16.21K	+100.00%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.03%	16.37K	150.63K	-1.09K	-6.23%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	17.24K	158.65K	-10.81K	-38.54%
Sep 30, 2025	JPMORGAN CHASE & CO	0.03%	18.07K	166.24K	-8.09K	-30.93%
Sep 30, 2025	MATISSE CAPITAL	0.03%	18.63K	171.4K	-7.47K	-28.62%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	25.9K	238.23K	-6.65K	-20.43%
Sep 30, 2025	BAILARD, INC.	0.04%	26.88K	247.31K	0	0
Sep 30, 2025	COUNTRY TRUST BANK	0.05%	30.04K	276.38K	-145	-0.48%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.05%	32.51K	299.06K	-1.24K	-3.68%
Sep 30, 2025	QUEST PARTNERS LLC	0.06%	35.38K	325.45K	35.38K	+100.00%
Sep 30, 2025	FOX RUN MANAGEMENT, L.L.C.	0.08%	50.79K	467.28K	50.79K	+100.00%
Sep 30, 2025	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.15%	95.4K	877.68K	-2.2K	-2.25%
Sep 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.1%	60K	611K	0	0
Sep 30, 2025	FRANKLIN RESOURCES INC	0.1%	60.02K	552.2K	0	0
Sep 30, 2025	BLACKROCK, INC.	5.93%	3.71M	34.1M	-672.27K	-15.35%
Sep 30, 2025	NUVEEN, LLC	0.18%	112.2K	1.03M	-12.52K	-10.04%
Sep 30, 2025	INVESCO LTD.	0.2%	123.87K	1.14M	-346.46K	-73.66%
Sep 30, 2025	J. GOLDMAN & CO LP	0.22%	135K	1.24M	67.5K	+100.00%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.24%	147.21K	1.35M	101.22K	+220.10%
Sep 30, 2025	PRINCIPAL FINANCIAL GROUP INC	0.11%	66.55K	612.26K	66.55K	+100.00%
Sep 30, 2025	RHUMBLINE ADVISERS	0.11%	69.37K	638.22K	-13.88K	-16.67%
Sep 30, 2025	ALLIANCEBERNSTEIN L.P.	0.12%	74.59K	686.23K	0	0
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.24%	150.87K	1.39M	45.17K	+42.74%
Sep 30, 2025	D. E. SHAW & CO., INC.	2.32%	1.45M	13.33M	272.71K	+23.18%
Sep 30, 2025	COMMONWEALTH EQUITY SERVICES, LLC	0.13%	83.43K	768K	0	0
Sep 30, 2025	CAMPBELL & CO INVESTMENT ADVISER LLC	0.16%	102.47K	942.72K	102.47K	+100.00%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.29%	179.36K	1.65M	52.96K	+41.89%
Sep 30, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.61%	384.14K	3.53M	41.59K	+12.14%
Sep 30, 2025	STRS OHIO	0.12%	77.9K	716.68K	2.8K	+3.73%
Sep 30, 2025	RBF CAPITAL, LLC	0.13%	80.51K	740.66K	0	0
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	3.89%	2.43M	22.37M	-2.16M	-47.00%
Sep 30, 2025	GSA CAPITAL PARTNERS LLP	0.19%	116.07K	1.07M	83.51K	+256.44%
Sep 30, 2025	ABRDN PLC	0.22%	137.96K	1.27M	79.27K	+135.04%
Sep 30, 2025	DEUTSCHE BANK AG\	0.46%	285.33K	2.63M	6.08K	+2.18%
Sep 30, 2025	AMERIPRISE FINANCIAL INC	0.2%	124.67K	1.15M	124.67K	+100.00%
Sep 30, 2025	JANE STREET GROUP, LLC	0.51%	321.52K	2.96M	304.09K	+1,744.95%
Sep 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.59%	366.3K	3.37M	161.9K	+79.21%
Sep 30, 2025	BRAIDWELL LP	0.35%	219.49K	2.02M	219.49K	+100.00%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.53%	333.48K	3.07M	-54.3K	-14.00%
Sep 30, 2025	CITADEL ADVISORS LLC	1.37%	854.56K	7.86M	688.32K	+414.07%
Sep 30, 2025	ROYAL BANK OF CANADA	1.6%	1M	9.21M	996.63K	+23,633.67%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.4%	248.2K	2.28M	169.7K	+216.18%
Sep 30, 2025	UBS GROUP AG	0.48%	301.16K	2.77M	165.95K	+122.74%
Sep 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.55%	341.61K	3.14M	288.26K	+540.33%
Sep 30, 2025	ACADIAN ASSET MANAGEMENT LLC	0.86%	540.64K	4.97M	-22.74K	-4.04%
Sep 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	1.08%	678.41K	6.24M	537.04K	+379.86%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	2.08%	1.3M	11.95M	-73.33K	-5.34%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	2.32%	1.45M	13.34M	112.27K	+8.39%
Sep 30, 2025	VANGUARD GROUP INC	4.8%	3M	27.6M	-146.98K	-4.67%
Sep 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	8.39%	5.25M	48.3M	0	0
Sep 30, 2025	SIMPLIFY ASSET MANAGEMENT INC.	0.13%	83.23K	765.75K	10.08K	+13.78%
Sep 30, 2025	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.18%	111.58K	1.03M	0	0
Sep 30, 2025	MORGAN STANLEY	0.39%	243.84K	2.24M	-70.58K	-22.45%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.61%	1M	9.24M	-189.09K	-15.85%
Sep 30, 2025	FARTHER FINANCE ADVISORS, LLC	0.01%	7.11K	65.43K	3.7K	+108.26%
Sep 30, 2025	FMR LLC	0.01%	7.35K	67.62K	383	+5.50%
Sep 30, 2025	BARCLAYS PLC	0.14%	89.62K	824.47K	-22.45K	-20.03%
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	16.36%	10.23M	94.11M	0	0
Sep 30, 2025	SUVRETTA CAPITAL MANAGEMENT, LLC	8.6%	5.38M	49.51M	298.1K	+5.86%
Sep 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	7.47%	4.67M	42.97M	382.49K	+8.92%
Sep 30, 2025	IKARIAN CAPITAL, LLC	2.06%	1.29M	11.86M	860.7K	+200.85%
Sep 30, 2025	STATE STREET CORP	1.7%	1.06M	9.78M	-155.16K	-12.74%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	0.94%	586.35K	5.39M	-557.19K	-48.72%
Sep 30, 2025	NORTHERN TRUST CORP	0.91%	568.32K	5.23M	-43.21K	-7.07%
Sep 30, 2025	BESSEMER GROUP INC	0.46%	286.99K	2.64M	0	0
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.24%	152.24K	1.4M	19.9K	+15.03%
Sep 30, 2025	FIDUCIARY TRUST CO	0.22%	136.56K	1.26M	0	0
Sep 30, 2025	HRT FINANCIAL LP	0.2%	124.92K	1.15M	124.92K	+100.00%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.19%	119.16K	1.1M	-17.84K	-13.02%
Sep 30, 2025	EXOME ASSET MANAGEMENT LLC	0.16%	98.8K	908.95K	-346.15K	-77.80%
Sep 30, 2025	VANGUARD PERSONALIZED INDEXING MANAGEMENT, LLC	0.02%	13.17K	121.15K	225	+1.74%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.02%	13.73K	126.32K	4.42K	+47.52%
Jun 30, 2025	BESSEMER GROUP INC	0.46%	286.99K	1.98M	0	0
Jun 30, 2025	PDT PARTNERS, LLC	0.04%	27.28K	187.69K	27.28K	+100.00%
Jun 30, 2025	VANGUARD PERSONALIZED INDEXING MANAGEMENT, LLC	0.02%	12.94K	89.05K	2.68K	+26.08%
Jun 30, 2025	GRAHAM CAPITAL MANAGEMENT, L.P.	0.02%	12.05K	82.92K	-154.19K	-92.75%
Jun 30, 2025	BARCLAYS PLC	0.18%	112.06K	771K	29.61K	+35.90%
Jun 30, 2025	D. E. SHAW & CO., INC.	1.88%	1.18M	8.1M	596.05K	+102.65%
Jun 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.04%	28.06K	193.04K	-17.63K	-38.59%
Jun 30, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0.05%	29.43K	202.5K	-2.16K	-6.83%
Jun 30, 2025	COUNTRY TRUST BANK	0.05%	30.19K	207.68K	0	0
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	0.21%	132.35K	910.56K	8.64K	+6.98%
Jun 30, 2025	ALLOSTERY INVESTMENTS LP	0.06%	40.35K	277.63K	40.35K	+100.00%
Jun 30, 2025	LMR PARTNERS LLP	0.08%	50K	344K	50K	+100.00%
Jun 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.09%	53.35K	367.04K	-437.18K	-89.12%
Jun 30, 2025	VANGUARD GROUP INC	5.03%	3.15M	21.65M	-73.94K	-2.30%
Jun 30, 2025	STATE STREET CORP	1.95%	1.22M	8.38M	-34.07K	-2.72%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.91%	1.19M	8.21M	-38.24K	-3.11%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	1.83%	1.14M	7.87M	740.94K	+184.04%
Jun 30, 2025	WOODLINE PARTNERS LP	1.44%	897.62K	6.18M	0	0
Jun 30, 2025	NORTHERN TRUST CORP	0.98%	611.54K	4.21M	-29.41K	-4.59%
Jun 30, 2025	ACADIAN ASSET MANAGEMENT LLC	0.9%	563.38K	3.87M	218.82K	+63.51%
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.8%	498.22K	3.43M	498.22K	+100.00%
Jun 30, 2025	INVESCO LTD.	0.75%	470.33K	3.24M	384.57K	+448.38%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.62%	387.78K	2.67M	6.42K	+1.68%
Jun 30, 2025	DEUTSCHE BANK AG\	0.45%	279.25K	1.92M	-561	-0.20%
Jun 30, 2025	UBS GROUP AG	0.22%	135.21K	930.21K	63.29K	+87.99%
Jun 30, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	0.15%	92.47K	636.19K	-55.18K	-37.37%
Jun 30, 2025	RHUMBLINE ADVISERS	0.13%	83.25K	572.75K	-5.74K	-6.45%
Jun 30, 2025	TWO SIGMA ADVISERS, LP	0.13%	82.1K	564.85K	-195.7K	-70.45%
Jun 30, 2025	ABRDN PLC	0.09%	58.7K	403.83K	58.7K	+100.00%
Jun 30, 2025	ACUTA CAPITAL PARTNERS, LLC	0.1%	59.65K	410.39K	59.65K	+100.00%
Jun 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.1%	60K	616K	0	0
Jun 30, 2025	J. GOLDMAN & CO LP	0.11%	67.5K	464.4K	47.25K	+233.33%
Jun 30, 2025	SIMPLIFY ASSET MANAGEMENT INC.	0.12%	73.15K	503.3K	-7.98K	-9.84%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.12%	74.59K	513.18M	9K	+13.72%
Jun 30, 2025	RBF CAPITAL, LLC	0.13%	80.51K	553.88K	0	0
Jun 30, 2025	MARTINGALE ASSET MANAGEMENT L P	0.15%	91.02K	626.18K	91.02K	+100.00%
Jun 30, 2025	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.18%	111.58K	767.68K	-39.06K	-25.93%
Jun 30, 2025	FIDUCIARY TRUST CO	0.22%	136.56K	939.5K	0	0
Jun 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.23%	141.38K	972.68K	81.85K	+137.48%
Jun 30, 2025	PRELUDE CAPITAL MANAGEMENT, LLC	0.23%	143.13K	984.73K	-49.08K	-25.53%
Jun 30, 2025		0.2%	124.72K	858.09K	-28.27K	-18.48%
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.33%	204.4K	1.41M	204.4K	+100.00%
Jun 30, 2025	IKARIAN CAPITAL, LLC	0.69%	428.52K	2.95M	228.43K	+114.16%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.2%	126.4K	869.65K	126.4K	+100.00%
Jun 30, 2025	SIMPLEX TRADING, LLC	0.17%	109.37K	752K	106.34K	+3,514.18%
Jun 30, 2025	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.16%	97.6K	671.49K	0	0
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.17%	105.69K	727.17K	65K	+159.74%
Jun 30, 2025	NUVEEN, LLC	0.2%	124.72K	858.09K	-28.27K	-18.48%
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.16%	99.49K	684.49K	34.65K	+53.44%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.22%	137K	942.56K	-6.59K	-4.59%
Jun 30, 2025	CITADEL ADVISORS LLC	0.27%	166.23K	1.14M	-208.02K	-55.58%
Jun 30, 2025	CATALIO CAPITAL MANAGEMENT, LP	0.3%	188.3K	1.3M	-13.84K	-6.84%
Jun 30, 2025	MORGAN STANLEY	0.5%	314.41K	2.16M	28.81K	+10.09%
Jun 30, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.55%	342.55K	2.36M	124.8K	+57.31%
Jun 30, 2025	EXOME ASSET MANAGEMENT LLC	0.71%	444.95K	3.06M	-244.19K	-35.43%
Jun 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	2.14%	1.34M	9.21M	1.34M	+100.00%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	2.19%	1.37M	9.44M	-34.41K	-2.45%
Jun 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	6.86%	4.29M	29.5M	-534.39K	-11.08%
Jun 30, 2025	BLACKROCK, INC.	7%	4.38M	30.13M	-331.67K	-7.04%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	7.34%	4.59M	31.57M	1.59M	+52.97%
Jun 30, 2025	SUVRETTA CAPITAL MANAGEMENT, LLC	8.13%	5.08M	34.97M	15.51K	+0.31%
Jun 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	8.39%	5.25M	36.12M	0	0
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	16.36%	10.23M	70.38M	0	0
Jun 30, 2025	COMMONWEALTH EQUITY SERVICES, LLC	0.13%	83.43K	574K	0	0
Jun 30, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.02%	13.47K	92.64K	13.47K	+100.00%
Jun 30, 2025	ALPHABET INC.	0.02%	14.26K	98.12K	0	0
Jun 30, 2025	WOLVERINE TRADING, LLC	0.03%	16.4K	116.44K	16.4K	+100.00%
Jun 30, 2025	EVERGREEN CAPITAL MANAGEMENT LLC	0.03%	16.5K	113.53K	16.5K	+100.00%
Jun 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.03%	18.05K	124.21M	445	+2.53%
Jun 30, 2025	MATISSE CAPITAL	0.04%	26.1K	179.57K	-70.62K	-73.01%
Jun 30, 2025	BAILARD, INC.	0.04%	26.88K	184.94K	26.88K	+100.00%
Jun 30, 2025	SHERBROOKE PARK ADVISERS LLC	0.04%	27.2K	187.14K	-28.14K	-50.85%
Mar 31, 2025	MORGAN STANLEY	0.46%	285.6K	822.53K	-1.25M	-81.35%
Mar 31, 2025	CITADEL ADVISORS LLC	0.6%	374.26K	1.08M	40.93K	+12.28%
Mar 31, 2025	UBS GROUP AG	0.12%	71.92K	207.13K	-5.47K	-7.07%
Mar 31, 2025	STATE STREET CORP	2%	1.25M	3.61M	7.12K	+0.57%
Mar 31, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	0.24%	147.65K	425.24K	147.65K	+100.00%
Mar 31, 2025	HSBC HOLDINGS PLC	0.12%	74.96K	218.51K	-998	-1.31%
Mar 31, 2025	TCG CROSSOVER MANAGEMENT, LLC	8.4%	5.25M	15.12M	0	0
Mar 31, 2025	BLACKROCK, INC.	7.54%	4.71M	13.57M	-458.73K	-8.87%
Mar 31, 2025	VANGUARD GROUP INC	5.15%	3.22M	9.27M	-29.23K	-0.90%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.64%	401.1K	1.16M	401.1K	+100.00%
Mar 31, 2025	TWO SIGMA ADVISERS, LP	0.44%	277.8K	800.06K	-65.8K	-19.15%
Mar 31, 2025	JPMORGAN CHASE & CO	0.34%	209.89K	604.49K	130.77K	+165.28%
Mar 31, 2025	RHUMBLINE ADVISERS	0.14%	88.99K	256.29K	386	+0.44%
Mar 31, 2025	INVESCO LTD.	0.14%	85.77K	247.01K	55.79K	+186.12%
Mar 31, 2025	SUVRETTA CAPITAL MANAGEMENT, LLC	8.11%	5.07M	14.59M	1.73M	+51.79%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.24%	150.27K	432.79K	-19.27K	-11.36%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.23%	143.59K	413.54K	1.72K	+1.21%
Mar 31, 2025	EXOME ASSET MANAGEMENT LLC	1.1%	689.14K	1.98M	405.54K	+143.00%
Mar 31, 2025	NORTHERN TRUST CORP	1.03%	640.95K	1.85M	-69.37K	-9.77%
Mar 31, 2025	D. E. SHAW & CO., INC.	0.93%	580.66K	1.67M	-2.54K	-0.44%
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.79%	490.53K	1.41M	294.28K	+149.96%
Mar 31, 2025	ACADIAN ASSET MANAGEMENT LLC	0.55%	344.56K	989K	308.85K	+864.97%
Mar 31, 2025	BESSEMER GROUP INC	0.46%	286.99K	827K	0	0
Mar 31, 2025	DEUTSCHE BANK AG\	0.45%	279.81K	805.86K	-5.68K	-1.99%
Mar 31, 2025	SHAY CAPITAL LLC	0.36%	224.31K	646K	-77.16K	-25.59%
Mar 31, 2025	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.24%	150.64K	433.85K	-62.57K	-29.35%
Mar 31, 2025		0.24%	152.99K	440.62K	152.99K	+100.00%
Mar 31, 2025	IKARIAN CAPITAL, LLC	0.32%	200.1K	576.28K	0	0
Mar 31, 2025	PRELUDE CAPITAL MANAGEMENT, LLC	0.31%	192.21K	553.56K	106.12K	+123.28%
Mar 31, 2025	GRAHAM CAPITAL MANAGEMENT, L.P.	0.27%	166.24K	478.78K	21.3K	+14.70%
Mar 31, 2025	COMMONWEALTH EQUITY SERVICES, LLC	0.13%	83.43K	240K	0	0
Mar 31, 2025	BARCLAYS PLC	0.13%	82.46K	238K	-39.61K	-32.45%
Mar 31, 2025	SIMPLIFY ASSET MANAGEMENT INC.	0.13%	81.13K	233.67K	420	+0.52%
Mar 31, 2025	RBF CAPITAL, LLC	0.13%	80.51K	231.86K	0	0
Mar 31, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.35%	217.75K	627.12K	-149.85K	-40.76%
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	16.37%	10.23M	29.46M	0	0
Mar 31, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	7.72%	4.82M	13.89M	42.99K	+0.90%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.97%	1.23M	3.55M	-63.14K	-4.88%
Mar 31, 2025	WOODLINE PARTNERS LP	1.44%	897.62K	2.59M	-512.9K	-36.36%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.64%	402.6K	1.16M	-139.66K	-25.75%
Mar 31, 2025	FIDUCIARY TRUST CO	0.22%	136.56K	393.28K	0	0
Mar 31, 2025	AMERICAN CENTURY COMPANIES INC	0.2%	123.71K	356.29K	3.1K	+2.57%
Mar 31, 2025	JANE STREET GROUP, LLC	0.19%	117.82K	339.31K	72.66K	+160.89%
Mar 31, 2025	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.16%	97.6K	281.09K	-42.4K	-30.29%
Mar 31, 2025	MATISSE CAPITAL	0.15%	96.72K	278.55K	-31.73K	-24.70%
Mar 31, 2025	STRS OHIO	0.15%	91.2K	262.66K	0	0
Mar 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	4.8%	3M	8.64M	0	0
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	2.25%	1.41M	4.05M	-11.64K	-0.82%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.61%	381.36K	1.1M	-144.69K	-27.50%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	0.92%	563.46K	5.32M	10.23K	+1.85%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	2.13%	1.3M	12.32M	329.53K	+33.79%
Mar 31, 2024	CITADEL ADVISORS LLC	2.16%	1.33M	12.51M	-78.49K	-5.59%
Mar 31, 2024	TRV GP IV, LLC	3.82%	2.34M	22.12M	0	0
Mar 31, 2024	SUSQUEHANNA PORTFOLIO STRATEGIES, LLC	0.28%	168.78K	1.59M	168.78K	+100.00%
Mar 31, 2024	CUBIST SYSTEMATIC STRATEGIES, LLC	0.28%	171.51K	1.62M	171.51K	+100.00%
Mar 31, 2024	WELLINGTON MANAGEMENT GROUP LLP	0.28%	172.66K	1.63M	172.66K	+100.00%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.29%	175.22K	1.65M	-86.53K	-33.06%
Mar 31, 2024	CITIGROUP INC	0.29%	178.56K	1.69M	-106.73K	-37.41%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.3%	186.97K	1.76M	-52.49K	-21.92%
Mar 31, 2024	ALYESKA INVESTMENT GROUP, L.P.	0.33%	202.15K	1.91M	0	0
Mar 31, 2024	MASS GENERAL BRIGHAM, INC	0.33%	205.36K	1.94M	205.36K	+100.00%
Mar 31, 2024	POINT72 ASSET MANAGEMENT, L.P.	0.36%	223.4K	2.11M	223.4K	+100.00%
Mar 31, 2024	MARSHALL WACE, LLP	0.37%	225.57K	2.13M	-279.53K	-55.34%
Mar 31, 2024	STATE STREET CORP	0.42%	256.86K	2.42M	73.71K	+40.25%
Mar 31, 2024	LOGOS GLOBAL MANAGEMENT LP	1.63%	1M	9.44M	1M	+100.00%
Mar 31, 2024	BLACKROCK INC.	2.51%	1.54M	14.55M	-20.66K	-1.32%
Mar 31, 2024	VANGUARD GROUP INC	4.14%	2.54M	23.96M	18.68K	+0.74%
Mar 31, 2024	SUVRETTA CAPITAL MANAGEMENT, LLC	4.65%	2.85M	26.89M	-2.67M	-48.39%
Mar 31, 2024	COWEN AND COMPANY, LLC	6.06%	3.71M	35.06M	240K	+6.91%
Mar 31, 2024	FMR LLC	8.75%	5.36M	50.64M	-319.95K	-5.63%
Mar 31, 2024	RTW INVESTMENTS, LP	9.54%	5.85M	55.19M	376K	+6.87%
Mar 31, 2024	RA CAPITAL MANAGEMENT, L.P.	18.94%	11.61M	109.6M	0	0
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.04%	24.49K	231.14K	0	0
Mar 31, 2024	FRANKLIN RESOURCES INC	0.04%	24.82K	234.31K	0	0
Mar 31, 2024	BROWN WEALTH MANAGEMENT, LLC	0.04%	25K	236K	0	0
Mar 31, 2024	DENALI ADVISORS LLC	0.04%	27.1K	255.82K	-30.7K	-53.11%
Mar 31, 2024	COUNTRY TRUST BANK	0.05%	30.19K	284.96K	0	0
Mar 31, 2024	SIMPLEX TRADING, LLC	0.05%	30.74K	290K	30.74K	+100.00%
Mar 31, 2024	JUMP FINANCIAL, LLC	0.05%	30.84K	291.17K	30.84K	+100.00%
Mar 31, 2024	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.05%	32.59K	111.15K	32.59K	+100.00%
Mar 31, 2024	ACUITAS INVESTMENTS, LLC	0.05%	33.22K	313.64K	-101.63K	-75.36%
Mar 31, 2024	ALPS ADVISORS INC	0.07%	43.68K	412.36K	3.83K	+9.61%
Mar 31, 2024	MARATHON TRADING INVESTMENT MANAGEMENT LLC	0.07%	45K	424.8K	45K	+100.00%
Mar 31, 2024	TREXQUANT INVESTMENT LP	0.08%	47.22K	445.78K	47.22K	+100.00%
Mar 31, 2024	HAP TRADING, LLC	0.08%	50K	120K	50K	+100.00%
Mar 31, 2024	Y-INTERCEPT (HONG KONG) LTD	0.09%	54.42K	513.69K	38K	+231.44%
Mar 31, 2024	DEKABANK DEUTSCHE GIROZENTRALE	0.1%	60K	568K	0	0
Mar 31, 2024	UBS GROUP AG	0.12%	72.77K	686.93K	42.59K	+141.09%
Mar 31, 2024	COMMONWEALTH EQUITY SERVICES, LLC	0.14%	83.43K	788K	83.43K	+100.00%
Mar 31, 2024	STIFEL FINANCIAL CORP	0.14%	85.01K	802.54K	13.56K	+18.98%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.15%	92.2K	870.41K	27.58K	+42.68%
Mar 31, 2024	LANDSCAPE CAPITAL MANAGEMENT, L.L.C.	0.15%	94.78K	894.68K	30.02K	+46.36%
Mar 31, 2024	HRT FINANCIAL LP	0.2%	123.41K	1.16M	123.41K	+100.00%
Mar 31, 2024	NORTHERN TRUST CORP	0.22%	136.43K	1.29M	-8.53K	-5.89%
Mar 31, 2024	FIDUCIARY TRUST CO	0.22%	136.56K	1.29M	0	0
Mar 31, 2024	CIBC WORLD MARKETS CORP	0.24%	150K	1.42M	150K	+100.00%
Mar 31, 2024	JPMORGAN CHASE & CO	0.26%	158.94K	1.5M	147.5K	+1,289.29%
Mar 31, 2024	ABRDN PLC	0.42%	256.89K	2.43M	0	0
Mar 31, 2024	BESSEMER GROUP INC	0.47%	286.99K	2.71M	0	0
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.5%	305.5K	2.88M	1.5K	+0.49%
Mar 31, 2024	ADAR1 CAPITAL MANAGEMENT, LLC	0.55%	339.83K	3.21M	-297.58K	-46.69%
Mar 31, 2024	SILVERARC CAPITAL MANAGEMENT, LLC	0.65%	398.44K	3.76M	398.44K	+100.00%
Mar 31, 2024	STEMPOINT CAPITAL LP	0.66%	407.11K	3.84M	30.54K	+8.11%
Mar 31, 2024	TWO SIGMA ADVISERS, LP	0.69%	420.2K	3.97M	-76K	-15.32%
Mar 31, 2024	INVESCO LTD.	0.81%	496.68K	4.69M	20.47K	+4.30%
Mar 31, 2024	JANE STREET GROUP, LLC	0.87%	535.06K	5.05M	188.21K	+54.26%
Mar 31, 2024	AFFINITY ASSET ADVISORS, LLC	0.45%	275K	2.6M	275K	+100.00%
Mar 31, 2024	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.8%	1.11M	10.44M	-400K	-26.55%
Mar 31, 2024	BIOIMPACT CAPITAL LLC	1.85%	1.14M	10.73M	1.14M	+100.00%
Mar 31, 2024	JEFFERIES FINANCIAL GROUP INC.	1.88%	1.15M	10.87M	-281.59K	-19.65%
Mar 31, 2024	CAPTION MANAGEMENT, LLC	0.51%	315.46K	2.98M	315.46K	+100.00%
Mar 31, 2024	MORGAN STANLEY	1.89%	1.16M	10.92M	-61.92K	-5.08%
Mar 31, 2024	D. E. SHAW & CO., INC.	1.02%	625.18K	5.9M	127.5K	+25.62%
Mar 31, 2024	SIMPLIFY ASSET MANAGEMENT INC.	1.1%	676.03K	6.38M	112.71K	+20.01%
Mar 31, 2024	VESTAL POINT CAPITAL, LP	1.13%	695K	6.56M	-330K	-32.20%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	1.18%	723.16K	6.83M	480.26K	+197.71%
Mar 31, 2024	ROCK SPRINGS CAPITAL MANAGEMENT LP	1.19%	727.67K	6.87M	0	0
Mar 31, 2024	PROPEL BIO MANAGEMENT, LLC	1.22%	750K	7.08M	0	0
Mar 31, 2024	GOLDMAN SACHS GROUP INC	1.32%	810.27K	7.65M	-61.23K	-7.03%
Mar 31, 2024	DEUTSCHE BANK AG\	1.34%	823.1K	7.77M	0	0
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	1.46%	897.46K	8.47M	459.96K	+105.13%
Dec 31, 2023	NORTHERN TRUST CORP	0.23%	144.97K	978.51K	1.98K	+1.39%
Dec 31, 2023	STATE STREET CORP	0.3%	183.15K	1.24M	0	0
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.3%	187.47K	1.27M	48.43K	+34.83%
Dec 31, 2023	ALYESKA INVESTMENT GROUP, L.P.	0.33%	202.15K	1.36M	0	0
Dec 31, 2023	ALLIANCEBERNSTEIN L.P.	0.39%	239.46K	1.62M	5.92K	+2.53%
Dec 31, 2023	QUBE RESEARCH & TECHNOLOGIES LTD	0.39%	242.91K	1.64M	229.84K	+1,759.08%
Dec 31, 2023	ABRDN PLC	0.42%	256.89K	1.73M	256.89K	+100.00%
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	0.42%	261.75K	1.77M	-300.37K	-53.44%
Dec 31, 2023	CITIGROUP INC	0.46%	285.3K	1.93M	196.11K	+219.88%
Dec 31, 2023	BESSEMER GROUP INC	0.46%	286.99K	1.94M	0	0
Dec 31, 2023	CITADEL ADVISORS LLC	0.54%	332.1K	2.24M	-18K	-5.14%
Dec 31, 2023	JANE STREET GROUP, LLC	0.56%	346.85K	2.34M	308.35K	+800.89%
Dec 31, 2023	FMR LLC	9.2%	5.68M	38.37M	-290.8K	-4.87%
Dec 31, 2023	RA CAPITAL MANAGEMENT, L.P.	18.78%	11.61M	78.37M	0	0
Dec 31, 2023	CLARIVEST ASSET MANAGEMENT LLC	0.17%	106.98K	722.1K	2.58K	+2.47%
Dec 31, 2023	JACOBS LEVY EQUITY MANAGEMENT, INC	0.2%	122.13K	824.38K	-143.38K	-54.00%
Dec 31, 2023	AFFINITY ASSET ADVISORS, LLC	0.2%	125K	843.75K	125K	+100.00%
Dec 31, 2023	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.2%	126.5K	853.88K	0	0
Dec 31, 2023	OPALEYE MANAGEMENT INC.	0.21%	130K	877.5K	130K	+100.00%
Dec 31, 2023	ACUITAS INVESTMENTS, LLC	0.22%	134.85K	910.24K	39	+0.03%
Dec 31, 2023	FIDUCIARY TRUST CO	0.22%	136.56K	921.75K	0	0
Dec 31, 2023	RBF CAPITAL, LLC	0.23%	140K	945K	-14.1K	-9.15%
Dec 31, 2023	LAURION CAPITAL MANAGEMENT LP	0.23%	144.72K	976.87K	144.72K	+100.00%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	0.71%	437.5K	2.95M	-567.18K	-56.45%
Dec 31, 2023	INVESCO LTD.	0.77%	476.21K	3.21M	476.21K	+100.00%
Dec 31, 2023	TWO SIGMA ADVISERS, LP	0.8%	496.2K	3.35M	-25.8K	-4.94%
Dec 31, 2023		0.61%	376.57K	2.54M	376.57K	+100.00%
Dec 31, 2023	SCHONFELD STRATEGIC ADVISORS LLC	0.7%	432.53K	2.92M	432.53K	+100.00%
Dec 31, 2023	D. E. SHAW & CO., INC.	0.81%	497.68K	3.36M	276.42K	+124.93%
Dec 31, 2023	MARSHALL WACE, LLP	0.82%	505.1K	3.41M	-543.54K	-51.83%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	0.89%	553.23K	3.74M	18.73K	+3.50%
Dec 31, 2023	SIMPLIFY ASSET MANAGEMENT INC.	0.91%	563.33K	3.8M	-7.19K	-1.26%
Dec 31, 2023	ROCK SPRINGS CAPITAL MANAGEMENT LP	1.18%	727.67K	4.91M	0	0
Dec 31, 2023	DEUTSCHE BANK AG\	1.33%	823.1K	5.56M	823.1K	+100.00%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	1.41%	871.5K	5.88M	612.28K	+236.19%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	1.58%	975.28K	6.58M	413.28K	+73.54%
Dec 31, 2023	LOGOS GLOBAL MANAGEMENT LP	1.94%	1.2M	8.1M	1.2M	+100.00%
Dec 31, 2023	MORGAN STANLEY	1.97%	1.22M	8.23M	307.19K	+33.69%
Dec 31, 2023	JEFFERIES FINANCIAL GROUP INC.	2.32%	1.43M	9.67M	0	0
Dec 31, 2023	ADAGE CAPITAL PARTNERS GP, L.L.C.	2.44%	1.51M	10.17M	-900K	-37.40%
Dec 31, 2023	BLACKROCK INC.	2.53%	1.56M	10.54M	115.93K	+8.02%
Dec 31, 2023	TRV GP IV, LLC	3.79%	2.34M	15.82M	0	0
Dec 31, 2023	VANGUARD GROUP INC	4.08%	2.52M	17.01M	-123.21K	-4.66%
Dec 31, 2023	COWEN AND COMPANY, LLC	5.62%	3.47M	23.45M	-834.43K	-19.37%
Dec 31, 2023	RTW INVESTMENTS, LP	8.85%	5.47M	36.92M	-348.85K	-6.00%
Dec 31, 2023	SUVRETTA CAPITAL MANAGEMENT, LLC	8.93%	5.52M	37.25M	-200K	-3.50%

Insiders

Among the FULC insiders holding of 1.82% of the stake in company, RA CAPITAL MANAGEMENT, L.P., 10 percent owner, holds the largest shares of 6.05M. LEVIN MARK J, , is the second largest FULC insider with ownership of 5.96M shares. THIRD ROCK VENTURES III, L.P., 10 percent owner, stands third with possession of 5.96M shares of that stake.

Insiders	Designation	Shares Held
RA CAPITAL MANAGEMENT, L.P.	10 percent owner	6.05M
LEVIN MARK J		5.96M
THIRD ROCK VENTURES III, L.P.	10 percent owner	5.96M
THIRD ROCK VENTURES IV, L.P.	10 percent owner	2.34M
CASDIN CAPITAL, LLC	10 percent owner	589.29K
6 DIMENSIONS CAPITAL, L.P.	10 percent owner	559.82K
SANOFI	10 percent owner	558.04K
GOULD ROBERT J	director	469.86K
WALLACE OWEN B.	Chief Scientific Officer	127.09K
GERAGHTY JAMES A	director	90.71K
CADAVID DIEGO	SVP Clinical Development	65.71K
SAPIR ALEX	See Remarks	43.36K
TOURANGEAU GREG	Principal Accounting Officer	14.06K
OLTMANS CURTIS GALE	Chief Legal Officer	10.25K
THOMSON PETER G.	VP Finance & Accounting	2.3K
MORABITO CHRISTOPHER	Chief Medical Officer	1.1K
MOXHAM CHRISTOPHER	Chief Scientific Officer	0
STUART BRYAN	See Remarks	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Jan 02, 2026	GOULD ROBERT J	SALE	11.87	15K	178.09K	469.86K
Dec 15, 2025	OLTMANS CURTIS GALE	SALE	12.92	3.45K	44.6K	10.25K
Dec 08, 2025	RA CAPITAL MANAGEMENT, L.P.	SALE	14.98	91.72K	1.37M	6.05M
Nov 19, 2025	GOULD ROBERT J	SALE	11.03	15K	165.5K	484.86K
May 08, 2025	TOURANGEAU GREG	SALE	5.06	498	2.52K	14.06K
May 07, 2024	TOURANGEAU GREG	SALE	7.76	236	1.83K	11.57K
Mar 08, 2024	TOURANGEAU GREG	SALE	11.72	4.88K	57.22K	11.81K
Mar 04, 2024	SAPIR ALEX	PURCHASE	11.35	43.36K	492.03K	43.36K
May 10, 2023	TOURANGEAU GREG	SALE	3.31	210	695.1	15.99K
Jan 20, 2023	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	13.00	1.92M	25M	11.61M
Jan 13, 2023	GOULD ROBERT J	SALE	15.00	6.77K	101.49K	499.86K
Jan 04, 2023	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	7.03	122.33K	859.71K	9.63M
Dec 27, 2022	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	5.99	4.09K	24.51K	9.51M
Dec 19, 2022	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	5.90	98.79K	582.81K	9.5M
Dec 16, 2022	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	5.42	1.34M	7.27M	9.4M
Dec 15, 2022	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	5.50	237.03K	1.3M	8.06M
Dec 14, 2022	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	5.46	824.6K	4.5M	7.82M
Jun 07, 2022	GOULD ROBERT J	SALE	8.09	71.44K	577.89K	506.63K
Jun 02, 2022	GOULD ROBERT J	SALE	7.92	16.69K	132.16K	506.63K
Apr 07, 2022	GOULD ROBERT J	SALE	24.02	5.63K	135.23K	506.63K
Apr 01, 2022	GOULD ROBERT J	SALE	24.26	52.55K	1.27M	506.63K
Aug 11, 2021	STUART BRYAN	SALE	23.75	28K	665K	0
Aug 10, 2021	STUART BRYAN	SALE	17.50	32K	560K	0
Aug 10, 2021	MOXHAM CHRISTOPHER	SALE	18.00	31.07K	559.28K	0
Jun 28, 2021	GERAGHTY JAMES A	PURCHASE	9.16	10K	91.6K	90.71K
Jun 28, 2021	MORABITO CHRISTOPHER	PURCHASE	9.16	1.1K	10.08K	1.1K
Jun 28, 2021	THOMSON PETER G.	PURCHASE	9.00	2.3K	20.7K	2.3K
Jun 28, 2021	OLTMANS CURTIS GALE	PURCHASE	9.01	1.09K	9.8K	1.09K
Mar 16, 2021	GOULD ROBERT J	SALE	12.43	789	9.81K	506.63K
Mar 15, 2021	GOULD ROBERT J	SALE	12.13	9.21K	111.77K	507.42K
Feb 22, 2021	THOMSON PETER G.	SALE	14.72	5K	73.58K	15.21K
Feb 16, 2021	GOULD ROBERT J	SALE	14.56	1.67K	24.37K	516.63K
Jan 21, 2021	THOMSON PETER G.	SALE	14.00	6.61K	92.5K	15.21K
Jan 20, 2021	GOULD ROBERT J	SALE	12.08	10K	120.83K	524.85K
Jul 08, 2020	WALLACE OWEN B.	SALE	20.00	2.95K	59.02K	127.09K
Jul 08, 2020	GOULD ROBERT J	SALE	20.00	2.5K	50K	534.85K
Jul 01, 2020	CADAVID DIEGO	SALE	18.30	1.07K	19.6K	65.71K
Jun 30, 2020	WALLACE OWEN B.	SALE	20.00	141	2.82K	127.09K
Jun 25, 2020	CADAVID DIEGO	SALE	22.00	1.46K	32.1K	66.79K
Jun 25, 2020	GOULD ROBERT J	SALE	20.80	2.5K	51.99K	537.35K
Jun 10, 2020	CADAVID DIEGO	SALE	22.00	401	8.82K	66.79K
Jun 09, 2020	GOULD ROBERT J	SALE	20.00	156	3.12K	539.85K
Jun 05, 2020	CADAVID DIEGO	SALE	20.18	451	9.1K	66.79K
Jun 05, 2020	GOULD ROBERT J	SALE	20.17	3.43K	69.25K	540K
Jun 04, 2020	CADAVID DIEGO	SALE	20.05	226	4.53K	66.79K
Jun 04, 2020	GOULD ROBERT J	SALE	20.04	1.3K	26.06K	543.43K
Jun 03, 2020	GOULD ROBERT J	SALE	20.13	1.5K	30.19K	544.73K
Jun 03, 2020	CADAVID DIEGO	SALE	20.18	338	6.82K	66.79K
Jun 02, 2020	CADAVID DIEGO	SALE	20.00	45	900	66.79K
Jun 02, 2020	GOULD ROBERT J	SALE	20.00	2.8K	55.94K	546.23K
Jun 01, 2020	GOULD ROBERT J	SALE	20.00	5	100	549.03K
May 29, 2020	CADAVID DIEGO	SALE	20.04	200	4.01K	66.79K
May 29, 2020	GOULD ROBERT J	SALE	20.08	1.39K	27.91K	549.04K
May 28, 2020	CADAVID DIEGO	SALE	20.00	600	12K	66.79K
May 28, 2020	GOULD ROBERT J	SALE	20.01	1.92K	38.39K	550.43K
May 28, 2020	WALLACE OWEN B.	SALE	20.00	2.23K	44.64K	127.09K
May 27, 2020	WALLACE OWEN B.	SALE	20.00	448	8.96K	127.09K
May 26, 2020	GOULD ROBERT J	SALE	20.00	2.5K	50K	552.35K
May 26, 2020	WALLACE OWEN B.	SALE	20.00	412	8.24K	127.09K
May 12, 2020	CADAVID DIEGO	SALE	18.00	1.86K	33.48K	66.79K
May 11, 2020	THOMSON PETER G.	SALE	16.00	7.5K	120K	21.07K
Mar 02, 2020	CADAVID DIEGO	SALE	18.13	315	5.71K	66.79K
Feb 24, 2020	THOMSON PETER G.	SALE	18.61	250	4.65K	28.57K
Feb 19, 2020	WALLACE OWEN B.	SALE	20.00	6.09K	121.76K	127.09K
Feb 19, 2020	GOULD ROBERT J	SALE	20.00	2.5K	50K	554.85K
Feb 03, 2020	CADAVID DIEGO	SALE	17.33	2.14K	37.14K	68.93K
Jan 23, 2020	THOMSON PETER G.	SALE	18.05	262	4.73K	33.57K
Jul 22, 2019	LEVIN MARK J	PURCHASE	16.00	81.25K	1.3M	5.96M
Jul 22, 2019	THIRD ROCK VENTURES III, L.P.	PURCHASE	16.00	81.25K	1.3M	5.96M
Jul 22, 2019	SANOFI	PURCHASE	16.00	93.75K	1.5M	558.04K
Jul 22, 2019	CASDIN CAPITAL, LLC	PURCHASE	16.00	125K	2M	589.29K
Jul 22, 2019	6 DIMENSIONS CAPITAL, L.P.	PURCHASE	16.00	118.75K	1.9M	559.82K
Jul 22, 2019	THIRD ROCK VENTURES IV, L.P.	PURCHASE	16.00	81.25K	1.3M	2.34M

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES125.17K4

NET SHARES-125.17K4

SHARES HELD7.02M4

% NET SHARES-101.78%0%

Frequently Asked Questions