How many institutions own EWTX stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own EWTX shares is 257, representing 116.34% of the company's common stock.

Who are the major shareholders selling Edgewise Therapeutics, Inc. stock?

GEODE CAPITAL MANAGEMENT, LLC, in the last quarter, reduced its stake in EWTX by -4.43% restricting it's holding to 1.72 million shares of worth nearly $27.86M. SIO CAPITAL MANAGEMENT, LLC also lessened -43.09% of the EWTX shares from its portfolio, reducing its holding to 307.18 thousand shares of worth $4.98M. GRANAHAN INVESTMENT MANAGEMENT, LLC also shunned EWTX shares holding by -16.24% last quarter which brought its holding to 339.62 thousand shares worth $5.51M.

Investors who are buying EWTX stock?

As per its latest 13F filing, BANK OF AMERICA CORP /DE/ increased its stake in EWTX by 26.22% in the last quarter. The institutional holder raised its holding to 321.13 thousand shares having worth more than $5.21M. OPALEYE MANAGEMENT INC. also added 2.04% more shares of EWTX to its portfolio, raising its holding to 500 thousand shares of worth $8.11M. EVERSEPT PARTNERS, LP also increased its EWTX shares holding by 27.88% which brought its holding to 502.23 thousand shares worth $8.15M.

EWTX's major insiders: who are they?

The insider with the most stakes in EWTX is OrbiMed Genesis GP LLC , at the company. Additionally, EWTX stock is highly held by 10 percent owner Novo Holdings A/S and 10 percent owner Flynn James E among others.

Did an insider recently sell EWTX stock?

Company executives, directors, and other insiders own 0.44% percent of Edgewise Therapeutics, Inc.'s stock. Within the last six months, there have been 8 transaction(s) in which EWTX insiders have sold stock, totaling 218.76K shares. Insiders that have sold shares include RUSSELL ALAN J, MOORE JOHN R, and DONOVAN JOANNE M..

Which insider recently purchased EWTX stock?

There have been 1 transaction(s) during the past 6-months in which Edgewise Therapeutics, Inc. insiders have bought stock, totalling 10700 shares

How much of EWTX does insiders own?

Around 269.9K Edgewise Therapeutics, Inc. shares are held by insiders, which represents about 0.44% of EWTX stock.

Who is the insider with the largest stake?

EWTX , OrbiMed Genesis GP LLC holds the largest portfolio of the company's shares. EWTX shares owned by OrbiMed total nearly 13.5 million.

Which institution holds the most shares in EWTX?

GEODE CAPITAL MANAGEMENT, LLC is the largest institutional owner in EWTX which holds 1.72 million shares worth $27.86M or 1.64% of the total EWTX shares outstanding followed by SIO CAPITAL MANAGEMENT, LLC with ownership of 307.18 thousand shares representing 0.29% of the EWTX ownership. BANK OF AMERICA CORP /DE/ is the third largest stakeholder with 321.13 thousand shares or 0.31% of the ownership worth more than $5.21M.

Is Edgewise Therapeutics, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the EWTX is concerned, it is a stock which is optionable.

Is there a short position on EWTX's shares?

Number of EWTX shares short is 10.19M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding EWTX shares are there?

As of today, 105.35M shares of EWTX are outstanding.

Is there many float in EWTX stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, EWTX has 60.53M shares in float.

EWTX short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for EWTX is 17.04.

Edgewise Therapeutics (EWTX) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares9.68

Short Percent Of Float11.36

Shares Outstanding105.35M

Shares Float60.53M

Shares Short10.19M

Short Ratio17.04

11.36%

Short % of Float

9.68%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

0.44% Percentage of Shares held by All Insiders

116.34% Percentage of Shares held by All Institutions

116.86% Percentage of Float held by Institutions

257

Number of Institutions Holding Shares

Institutional Ownership

About 116.34% of EWTX shares are held by financial institutions. GEODE CAPITAL MANAGEMENT, LLC is the top corporate investor, holding 1.72M shares valued at $27.86M. A 1.64% stake in Edgewise Therapeutics, Inc. is owned by the company. SIO CAPITAL MANAGEMENT, LLC owns 307.18K shares valued at $4.98M, which translates its holding of 0.29% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.64%	1.72M	27.86M	-79.57K	-4.43%
Sep 30, 2025	SIO CAPITAL MANAGEMENT, LLC	0.29%	307.18K	4.98M	-232.55K	-43.09%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.31%	321.13K	5.21M	66.7K	+26.22%
Sep 30, 2025	GRANAHAN INVESTMENT MANAGEMENT, LLC	0.32%	339.62K	5.51M	-65.86K	-16.24%
Sep 30, 2025	TANG CAPITAL MANAGEMENT LLC	0.41%	431.3K	7M	0	0
Sep 30, 2025	OPALEYE MANAGEMENT INC.	0.48%	500K	8.11M	10K	+2.04%
Sep 30, 2025	EVERSEPT PARTNERS, LP	0.48%	502.23K	8.15M	109.5K	+27.88%
Sep 30, 2025	SOFINNOVA INVESTMENTS, INC.	0.5%	520.24K	8.44M	-196.63K	-27.43%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	0.5%	527.83K	8.56M	-103.92K	-16.45%
Sep 30, 2025	CITIGROUP INC	0.51%	538.45K	8.73M	-186.45K	-25.72%
Sep 30, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.52%	550.17K	8.92M	-97.16K	-15.01%
Sep 30, 2025	NORTHERN TRUST CORP	0.56%	587.88K	9.54M	-15.02K	-2.49%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.57%	597.6K	9.69M	18.5K	+3.19%
Sep 30, 2025	WOODLINE PARTNERS LP	0.21%	224.19K	3.64M	-872.67K	-79.56%
Sep 30, 2025	BARCLAYS PLC	0.22%	234.65K	3.81M	-46.6K	-16.57%
Sep 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	0.54%	568.31K	9.22M	0	0
Sep 30, 2025	ABRDN PLC	0.59%	619.88K	10.05M	176.56K	+39.83%
Sep 30, 2025	ARTISAN PARTNERS LIMITED PARTNERSHIP	0.68%	718.18K	11.65M	-660.89K	-47.92%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.69%	725.43K	11.77M	-196.54K	-21.32%
Sep 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.73%	765.69K	12.42M	-1.3M	-62.96%
Sep 30, 2025	MORGAN STANLEY	0.83%	869.68K	14.11M	141.96K	+19.51%
Sep 30, 2025	NEW LEAF VENTURE PARTNERS, L.L.C.	0.98%	1.03M	16.71M	0	0
Sep 30, 2025	INTEGRAL HEALTH ASSET MANAGEMENT, LLC	1.43%	1.5M	24.33M	500K	+50.00%
Sep 30, 2025	STATE STREET CORP	1.62%	1.7M	27.57M	-81.59K	-4.58%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	1.04%	1.1M	17.77M	312.31K	+39.88%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	1.13%	1.18M	19.19M	134.2K	+12.79%
Sep 30, 2025	FIRST LIGHT ASSET MANAGEMENT, LLC	1.35%	1.41M	22.95M	-299.03K	-17.45%
Sep 30, 2025	SIREN, L.L.C.	3.71%	3.9M	63.21M	736.8K	+23.31%
Sep 30, 2025	VANGUARD GROUP INC	4.58%	4.8M	77.92M	-37.56K	-0.78%
Sep 30, 2025	BIOIMPACT CAPITAL LLC	1.64%	1.72M	27.91M	0	0
Sep 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	2.12%	2.23M	36.14M	126.5K	+6.02%
Sep 30, 2025	BELLEVUE GROUP AG	2.65%	2.78M	45.03M	0	0
Sep 30, 2025	PERCEPTIVE ADVISORS LLC	3.62%	3.8M	61.57M	-844.06K	-18.19%
Sep 30, 2025	CORMORANT ASSET MANAGEMENT, LP	3.82%	4.01M	65.04M	-241.99K	-5.69%
Sep 30, 2025	BRAIDWELL LP	4.97%	5.21M	84.52M	0	0
Sep 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.24%	250.62K	4.07M	-1.9K	-0.75%
Sep 30, 2025	NOVO HOLDINGS A/S	5.1%	5.35M	86.78M	0	0
Sep 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	5.88%	6.17M	100.08M	27.79K	+0.45%
Sep 30, 2025	BLACKROCK, INC.	6.05%	6.35M	103.02M	-429.56K	-6.33%
Sep 30, 2025	PROSHARE ADVISORS LLC	0.01%	15.29K	248.02K	-3.6K	-19.04%
Sep 30, 2025	ARIZONA STATE RETIREMENT SYSTEM	0.01%	15.55K	252.21K	1.8K	+13.12%
Sep 30, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	18.47K	299.52K	-2.65K	-12.57%
Sep 30, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.02%	18.87K	305.99K	1.51K	+8.69%
Sep 30, 2025	FOX RUN MANAGEMENT, L.L.C.	0.02%	20.47K	332.04K	20.47K	+100.00%
Sep 30, 2025	OPTIMIZE FINANCIAL INC	0.03%	27.28K	442.53K	27.28K	+100.00%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	29.18K	473.28K	-14.89K	-33.78%
Sep 30, 2025	HANDELSBANKEN FONDER AB	0.04%	38.4K	623K	9.7K	+33.80%
Sep 30, 2025	SEI INVESTMENTS CO	0.04%	39.1K	634.12K	-4.54K	-10.41%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.04%	42.2K	684.42K	3.81K	+9.93%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	43.88K	711.78K	0	0
Sep 30, 2025	FRANKLIN RESOURCES INC	0.05%	48.22K	782.13K	2.41K	+5.27%
Sep 30, 2025	ALPS ADVISORS INC	0.05%	51.11K	829.04K	-5.69K	-10.01%
Sep 30, 2025	HIGHMARK WEALTH MANAGEMENT LLC	0.05%	53.18K	862.56K	1.11K	+2.14%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.05%	55.94K	907.36K	3.63K	+6.95%
Sep 30, 2025	Y-INTERCEPT (HONG KONG) LTD	0.05%	57.3K	929.41K	57.3K	+100.00%
Sep 30, 2025	FEDERATED HERMES, INC.	0.06%	59.26K	961.13K	-257.24K	-81.28%
Sep 30, 2025	INVESCO LTD.	0.06%	66.06K	1.07M	9.9K	+17.63%
Sep 30, 2025	JPMORGAN CHASE & CO	0.07%	68.72K	1.11M	-8.9K	-11.46%
Sep 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.08%	80K	1.55M	0	0
Sep 30, 2025	JUMP FINANCIAL, LLC	0.08%	80.83K	1.31M	-40.88K	-33.59%
Sep 30, 2025	MOODY ALDRICH PARTNERS LLC	0.08%	82.94K	1.35M	-16.91K	-16.93%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.08%	83.44K	1.35M	-10.37K	-11.06%
Sep 30, 2025	SWISS NATIONAL BANK	0.1%	101.9K	1.65M	11.9K	+13.22%
Sep 30, 2025	RHUMBLINE ADVISERS	0.1%	104.83K	1.7M	-7.65K	-6.80%
Sep 30, 2025	QUANTUM PRIVATE WEALTH, LLC	0.1%	105.87K	1.72M	5.1K	+5.06%
Sep 30, 2025	GSA CAPITAL PARTNERS LLP	0.11%	113.24K	1.84M	85.97K	+315.17%
Sep 30, 2025	UBS GROUP AG	0.11%	114.13K	1.85M	-56.85K	-33.25%
Sep 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.13%	132.5K	2.15M	325	+0.25%
Sep 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.14%	151.06K	2.38M	0	0
Sep 30, 2025	DEUTSCHE BANK AG\	0.15%	154.9K	2.51M	7.37K	+5.00%
Sep 30, 2025	NUVEEN, LLC	0.16%	172.71K	2.8M	-144.47K	-45.55%
Sep 30, 2025	D. E. SHAW & CO., INC.	0.65%	677.56K	10.99M	82.13K	+13.79%
Sep 30, 2025	JANUS HENDERSON GROUP PLC	4.74%	4.98M	80.8M	-524.02K	-9.52%
Sep 30, 2025	EXOME ASSET MANAGEMENT LLC	0.17%	173.44K	2.81M	48.97K	+39.34%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.19%	204.24K	3.31M	-8.62K	-4.05%
Sep 30, 2025	HIGHVISTA STRATEGIES LLC	0.2%	208.1K	3.38M	138.38K	+198.47%
Sep 30, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.2%	213.74K	3.47M	-24.4K	-10.25%
Sep 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.53%	555.71K	9.01M	55.8K	+11.16%
Sep 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.48%	498.65K	8.09M	55.81K	+12.60%
Sep 30, 2025	BAKER BROS. ADVISORS LP	6.96%	7.31M	118.5M	0	0
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	9.94%	10.43M	169.15M	525.8K	+5.31%
Sep 30, 2025	ORBIMED ADVISORS LLC	14.79%	15.52M	251.71M	0	0
Sep 30, 2025	NEUBERGER BERMAN GROUP LLC	0.21%	219.65K	3.56M	54.11K	+32.69%
Sep 30, 2025	CANDRIAM S.C.A.	0.21%	221.16K	3.59M	-2.83K	-1.26%
Sep 30, 2025	FMR LLC	0.24%	253.33K	4.11M	-217.39K	-46.18%
Sep 30, 2025	KYNAM CAPITAL MANAGEMENT, LP	0.24%	253.98K	4.12M	0	0
Jun 30, 2025	FMR LLC	0.45%	470.72K	6.17M	284.69K	+153.04%
Jun 30, 2025	FEDERATED HERMES, INC.	0.3%	316.5K	4.15M	316.42K	+395,525.00%
Jun 30, 2025	KYNAM CAPITAL MANAGEMENT, LP	0.24%	253.98K	3.33M	253.98K	+100.00%
Jun 30, 2025	SOFINNOVA INVESTMENTS, INC.	0.68%	716.87K	9.4M	374.66K	+109.48%
Jun 30, 2025	NORTHERN TRUST CORP	0.57%	602.9K	7.9M	-3.79K	-0.63%
Jun 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	0.54%	568.31K	7.45M	0	0
Jun 30, 2025	SIO CAPITAL MANAGEMENT, LLC	0.51%	539.73K	7.08M	539.73K	+100.00%
Jun 30, 2025	ALPS ADVISORS INC	0.05%	56.8K	744.62K	-11.18K	-16.44%
Jun 30, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.23%	238.14K	3.12M	55K	+30.03%
Jun 30, 2025	CANDRIAM S.C.A.	0.21%	223.99K	2.94M	-1.81K	-0.80%
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.16%	167.34K	2.19M	-111.63K	-40.02%
Jun 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.14%	151.06K	1.98M	71.91K	+90.85%
Jun 30, 2025	INTEGRAL HEALTH ASSET MANAGEMENT, LLC	0.95%	1M	13.11M	325K	+48.15%
Jun 30, 2025		0.3%	317.17K	4.16M	114.59K	+56.57%
Jun 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.24%	252.52K	3.31M	27.82K	+12.38%
Jun 30, 2025	JUMP FINANCIAL, LLC	0.12%	121.71K	1.6M	121.71K	+100.00%
Jun 30, 2025	CAMPBELL & CO INVESTMENT ADVISER LLC	0.11%	114.18K	1.5M	114.18K	+100.00%
Jun 30, 2025	QUANTUM PRIVATE WEALTH, LLC	0.1%	100.77K	1.32M	10.05K	+11.08%
Jun 30, 2025	POLAR CAPITAL HOLDINGS PLC	0.93%	975K	12.78M	725K	+290.00%
Jun 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	2%	2.1M	27.55M	726.04K	+52.77%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.24%	254.43K	3.34M	-441K	-63.41%
Jun 30, 2025	BARCLAYS PLC	0.27%	281.25K	3.69M	172.69K	+159.07%
Jun 30, 2025	EVERSEPT PARTNERS, LP	0.37%	392.74K	5.15M	392.74K	+100.00%
Jun 30, 2025	GRANAHAN INVESTMENT MANAGEMENT, LLC	0.39%	405.48K	5.32M	187.81K	+86.28%
Jun 30, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.62%	647.33K	8.49M	221.92K	+52.17%
Jun 30, 2025	TANG CAPITAL MANAGEMENT LLC	0.41%	431.3K	5.65M	131.3K	+43.77%
Jun 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.42%	442.84K	5.81M	442.84K	+100.00%
Jun 30, 2025	ABRDN PLC	0.42%	443.32K	5.81M	130.29K	+41.62%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.55%	579.1K	7.59M	57.84K	+11.10%
Jun 30, 2025	CITIGROUP INC	0.69%	724.9K	9.5M	650.59K	+875.55%
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	0.75%	783.17K	10.27M	3.4K	+0.44%
Jun 30, 2025	NEW LEAF VENTURE PARTNERS, L.L.C.	0.98%	1.03M	13.51M	0	0
Jun 30, 2025	NUVEEN, LLC	0.3%	317.17K	4.16M	114.59K	+56.57%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.88%	921.97K	12.09M	306.85K	+49.88%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	1%	1.05M	13.75M	381.44K	+57.14%
Jun 30, 2025	WOODLINE PARTNERS LP	1.05%	1.1M	14.38M	54	0.00%
Jun 30, 2025	ARTISAN PARTNERS LIMITED PARTNERSHIP	1.31%	1.38M	18.08M	461.85K	+50.35%
Jun 30, 2025	BIOIMPACT CAPITAL LLC	1.64%	1.72M	22.56M	615.3K	+55.66%
Jun 30, 2025	FORESITE CAPITAL MANAGEMENT VI LLC	0.56%	585K	7.67M	0	0
Jun 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.08%	80K	1.56M	0	0
Jun 30, 2025	OPALEYE MANAGEMENT INC.	0.47%	490K	6.42M	95K	+24.05%
Jun 30, 2025	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.27%	284.55K	3.73M	284.55K	+100.00%
Jun 30, 2025	STATE STREET CORP	1.7%	1.78M	23.36M	63.78K	+3.71%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.71%	1.8M	23.56M	141.55K	+8.55%
Jun 30, 2025	XTX TOPCO LTD	0.06%	60.74K	796.29K	60.74K	+100.00%
Jun 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.97%	2.07M	27.1M	-11.19K	-0.54%
Jun 30, 2025	JANUS HENDERSON GROUP PLC	5.24%	5.5M	72.13M	221.2K	+4.19%
Jun 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	5.85%	6.14M	80.53M	1.75M	+39.77%
Jun 30, 2025	CITADEL ADVISORS LLC	0.31%	325.25K	4.26B	227.97K	+234.35%
Jun 30, 2025	D. E. SHAW & CO., INC.	0.57%	595.43K	7.81B	454.88K	+323.65%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.6%	631.74K	8.28B	265.1K	+72.30%
Jun 30, 2025	MORGAN STANLEY	0.69%	727.71K	9.54B	318.72K	+77.93%
Jun 30, 2025	BLACKROCK, INC.	6.46%	6.78M	88.9M	296.04K	+4.57%
Jun 30, 2025	BAKER BROS. ADVISORS LP	6.96%	7.31M	95.78M	1.15M	+18.68%
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	9.44%	9.9M	129.82M	993.54K	+11.15%
Jun 30, 2025	ORBIMED ADVISORS LLC	14.79%	15.52M	203.45M	496.77K	+3.31%
Jun 30, 2025	TWINBEECH CAPITAL LP	0.07%	78.28K	1.03M	-22.55K	-22.36%
Jun 30, 2025	PERCEPTIVE ADVISORS LLC	4.42%	4.64M	60.83M	-1.91M	-29.13%
Jun 30, 2025	BELLEVUE GROUP AG	2.65%	2.78M	36.39M	1.35M	+94.27%
Jun 30, 2025	SIREN, L.L.C.	3.01%	3.16M	41.43M	1.46M	+86.29%
Jun 30, 2025	VANGUARD GROUP INC	4.61%	4.84M	63.47M	547.1K	+12.74%
Jun 30, 2025	BRAIDWELL LP	4.97%	5.21M	68.31M	2.75M	+111.93%
Jun 30, 2025	NOVO HOLDINGS A/S	5.1%	5.35M	70.14M	0	0
Jun 30, 2025	HIGHVISTA STRATEGIES LLC	0.07%	69.72K	914.07K	-21.48K	-23.56%
Jun 30, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.07%	76.49K	1M	4.19K	+5.80%
Jun 30, 2025	GRAHAM CAPITAL MANAGEMENT, L.P.	0.04%	40.36K	529.17K	23.32K	+136.78%
Jun 30, 2025	QUANTBOT TECHNOLOGIES LP	0.04%	41.46K	543.58K	41.46K	+100.00%
Jun 30, 2025	TUDOR INVESTMENT CORP ET AL	0.04%	41.66K	546.2K	-5.14K	-10.98%
Jun 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.04%	44.07K	577.69K	-2.14K	-4.64%
Jun 30, 2025	VERITION FUND MANAGEMENT LLC	0.04%	44.07K	577.75K	9.35K	+26.93%
Jun 30, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.04%	45.26K	593K	45.26K	+100.00%
Jun 30, 2025	HIGHMARK WEALTH MANAGEMENT LLC	0.05%	52.07K	682.57K	51.9K	+31,454.55%
Jun 30, 2025	STATE OF WISCONSIN INVESTMENT BOARD	0.05%	54.02K	708.19K	-17.11K	-24.06%
Jun 30, 2025	UBS OCONNOR LLC	0.05%	55.29K	724.88K	15.28K	+38.18%
Jun 30, 2025	MOODY ALDRICH PARTNERS LLC	0.1%	99.85K	1.31M	-82.25K	-45.17%
Jun 30, 2025	WALLEYE CAPITAL LLC	0.08%	86.88K	1.14M	70.7K	+437.04%
Jun 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.48%	499.92K	6.55M	102.34K	+25.74%
Jun 30, 2025	CORMORANT ASSET MANAGEMENT, LP	4.05%	4.25M	55.74M	150K	+3.66%
Jun 30, 2025	FIRST LIGHT ASSET MANAGEMENT, LLC	1.63%	1.71M	22.47M	-138.27K	-7.46%
Mar 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	1.45%	1.38M	30.27M	-118.05K	-7.90%
Mar 31, 2025	SIREN, L.L.C.	1.78%	1.7M	37.32M	962.1K	+131.02%
Mar 31, 2025	BRAIDWELL LP	2.58%	2.46M	54.09M	126.61K	+5.43%
Mar 31, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	2.18%	2.08M	45.73M	0	0
Mar 31, 2025	WOODLINE PARTNERS LP	1.15%	1.1M	24.13M	529.59K	+93.37%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.7%	667.5K	14.69M	-62.42K	-8.55%
Mar 31, 2025	NORTHERN TRUST CORP	0.64%	606.69K	13.35M	-4.61K	-0.75%
Mar 31, 2025	EVENTIDE ASSET MANAGEMENT, LLC	0.6%	568.31K	12.5M	568.31K	+100.00%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.65%	615.12K	13.53M	-273.85K	-30.81%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.74%	1.66M	36.43M	55.09K	+3.44%
Mar 31, 2025	BELLEVUE GROUP AG	1.5%	1.43M	31.44M	0	0
Mar 31, 2025	FORESITE CAPITAL MANAGEMENT VI LLC	0.61%	585K	12.87M	0	0
Mar 31, 2025	DEEP TRACK CAPITAL, LP	1.47%	1.4M	30.8M	689.58K	+97.07%
Mar 31, 2025	BIOIMPACT CAPITAL LLC	1.16%	1.11M	24.32M	26.13K	+2.42%
Mar 31, 2025	ARTISAN PARTNERS LIMITED PARTNERSHIP	0.96%	917.22K	20.18M	-154.37K	-14.41%
Mar 31, 2025	FIRST LIGHT ASSET MANAGEMENT, LLC	1.95%	1.85M	40.75M	1.07M	+137.28%
Mar 31, 2025	STATE STREET CORP	1.81%	1.72M	37.79M	2.18K	+0.13%
Mar 31, 2025	CAPTION MANAGEMENT, LLC	0.61%	580.1K	12.76M	580.1K	+100.00%
Mar 31, 2025	ORBIMED ADVISORS LLC	15.79%	15.02M	330.48M	0	0
Mar 31, 2025	AMERICAN CENTURY COMPANIES INC	0.82%	779.77K	17.15M	9.41K	+1.22%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.73%	695.43K	15.3M	646.52K	+1,321.94%
Mar 31, 2025	INTEGRAL HEALTH ASSET MANAGEMENT, LLC	0.71%	675K	14.85M	125K	+22.73%
Mar 31, 2025	SOFINNOVA INVESTMENTS, INC.	0.34%	320.4K	7.05M	320.4K	+100.00%
Mar 31, 2025	ABRDN PLC	0.33%	313.03K	6.89M	134.98K	+75.81%
Mar 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.32%	302.51K	6.66M	1.27K	+0.42%
Mar 31, 2025	AMUNDI	0.32%	308.63K	4.19M	-33.05K	-9.67%
Mar 31, 2025	TANG CAPITAL MANAGEMENT LLC	0.32%	300K	6.6M	0	0
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	9.37%	8.91M	196M	0	0
Mar 31, 2025	BLACKROCK, INC.	6.82%	6.49M	142.67M	5.99K	+0.09%
Mar 31, 2025	BAKER BROS. ADVISORS LP	6.47%	6.16M	135.43M	0	0
Mar 31, 2025	NOVO HOLDINGS A/S	5.62%	5.35M	117.7M	350K	+7.00%
Mar 31, 2025	JANUS HENDERSON GROUP PLC	5.55%	5.28M	122.85M	298.21K	+5.98%
Mar 31, 2025	VANGUARD GROUP INC	4.51%	4.29M	94.48M	-172.45K	-3.86%
Mar 31, 2025	CORMORANT ASSET MANAGEMENT, LP	4.31%	4.1M	90.24M	695.46K	+20.42%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.55%	521.26K	11.47M	-16.1K	-3.00%
Mar 31, 2025	PERCEPTIVE ADVISORS LLC	0.53%	500K	11M	500K	+100.00%
Mar 31, 2025	PARADIGM BIOCAPITAL ADVISORS LP	0.53%	500K	11M	500K	+100.00%
Mar 31, 2025	VIKING GLOBAL INVESTORS LP	0.52%	490.04K	10.78M	-734.95K	-60.00%
Mar 31, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.45%	425.41K	9.36M	44.23K	+11.60%
Mar 31, 2025	MORGAN STANLEY	0.43%	409K	9M	-27.43K	-6.29%
Mar 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.42%	397.57K	8.75M	28.13K	+7.61%
Mar 31, 2025	OPALEYE MANAGEMENT INC.	0.42%	395K	8.69M	-85K	-17.71%
Mar 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.41%	390K	8.58M	150K	+62.50%
Mar 31, 2025	DEUTSCHE BANK AG\	0.4%	376.06K	8.27M	100.22K	+36.33%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.39%	366.64K	8.07M	19.75K	+5.69%
Mar 31, 2025	READYSTATE ASSET MANAGEMENT LP	0.38%	361.23K	7.95M	339.87K	+1,591.01%
Mar 31, 2024	RHUMBLINE ADVISERS	0.13%	84.23K	1.54M	19.9K	+30.93%
Mar 31, 2024	TREXQUANT INVESTMENT LP	0.2%	126.33K	2.3M	70.74K	+127.25%
Mar 31, 2024	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.28%	175.9K	3.21M	175.9K	+100.00%
Mar 31, 2024	ADAR1 CAPITAL MANAGEMENT, LLC	0.28%	180.91K	3.3M	180.91K	+100.00%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.33%	212.27K	3.87M	66.1K	+45.22%
Mar 31, 2024	SCHONFELD STRATEGIC ADVISORS LLC	0.45%	284.6K	5.19M	-34.5K	-10.81%
Mar 31, 2024	KENNEDY CAPITAL MANAGEMENT LLC	0.46%	293.27K	5.35M	-49.6K	-14.47%
Mar 31, 2024	DAFNA CAPITAL MANAGEMENT LLC	0.48%	306.2K	5.59M	-143.19K	-31.86%
Mar 31, 2024	CANDRIAM S.C.A.	0.52%	329K	6M	21K	+6.82%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.53%	338K	6.17M	184.71K	+120.50%
Mar 31, 2024	MORGAN STANLEY	0.59%	374.72K	6.83M	149.54K	+66.41%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.62%	392.74K	7.16M	223.19K	+131.64%
Mar 31, 2024	WOODLINE PARTNERS LP	0.64%	405.13K	7.39M	920	+0.23%
Mar 31, 2024	PARKMAN HEALTHCARE PARTNERS LLC	1.03%	653.65K	11.92M	2.03K	+0.31%
Mar 31, 2024	OPALEYE MANAGEMENT INC.	1.04%	665K	12.13M	-34K	-4.86%
Mar 31, 2024	DRIEHAUS CAPITAL MANAGEMENT LLC	1.99%	1.27M	23.13M	872.75K	+220.91%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	2.15%	1.37M	24.99M	422.85K	+44.65%
Mar 31, 2024	NEW LEAF VENTURE PARTNERS, L.L.C.	2.44%	1.55M	28.34M	0	0
Mar 31, 2024	GOLDMAN SACHS GROUP INC	2.74%	1.75M	31.88M	865.95K	+98.19%
Mar 31, 2024	JANUS HENDERSON GROUP PLC	2.83%	1.81M	32.9M	590.3K	+48.58%
Mar 31, 2024	VR ADVISER, LLC	2.85%	1.82M	33.16M	1.82M	+100.00%
Mar 31, 2024	TCG CROSSOVER MANAGEMENT, LLC	3.57%	2.27M	41.45M	2.27M	+100.00%
Mar 31, 2024	PERCEPTIVE ADVISORS LLC	3.64%	2.32M	42.31M	1.76M	+317.54%
Mar 31, 2024	CITADEL ADVISORS LLC	4.27%	2.72M	49.6M	133.36K	+5.16%
Mar 31, 2024	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	4.51%	2.87M	52.43M	-1.06M	-26.91%
Mar 31, 2024	CORMORANT ASSET MANAGEMENT, LP	4.72%	3.01M	54.84M	454.55K	+17.81%
Mar 31, 2024	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	5.18%	3.3M	60.26M	636.36K	+23.86%
Mar 31, 2024	VIKING GLOBAL INVESTORS LP	5.24%	3.34M	60.91M	-2.82M	-45.79%
Mar 31, 2024	VANGUARD GROUP INC	6.3%	4.02M	73.28M	1.89M	+89.02%
Mar 31, 2024	BLACKROCK INC.	8.11%	5.17M	94.25M	1.86M	+56.24%
Mar 31, 2024	FMR LLC	9.99%	6.37M	116.11M	-126.79K	-1.95%
Mar 31, 2024	ORBIMED ADVISORS LLC	23.57%	15.02M	274M	454.55K	+3.12%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	0.47%	299.29K	5.46M	37.05K	+14.13%
Mar 31, 2024	BIOIMPACT CAPITAL LLC	0.69%	441.26K	8.05M	441.26K	+100.00%
Mar 31, 2024	WELLINGTON MANAGEMENT GROUP LLP	0.74%	472.9K	8.63M	132K	+38.72%
Mar 31, 2024	D. E. SHAW & CO., INC.	0.74%	473.68K	8.64M	441.73K	+1,382.57%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.78%	497.16K	9.07M	166.1K	+50.17%
Mar 31, 2024	NORTHERN TRUST CORP	0.78%	499.52K	9.11M	136.28K	+37.52%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	0.84%	532.26K	9.71M	400.9K	+305.20%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.88%	559.33K	10.2M	-211.12K	-27.40%
Mar 31, 2024	GRANAHAN INVESTMENT MANAGEMENT, LLC	0.95%	608.01K	11.09M	-466.9K	-43.44%
Mar 31, 2024	ARTAL GROUP S.A.	1.27%	811.72K	14.81M	811.72K	+100.00%
Mar 31, 2024	STATE STREET CORP	1.9%	1.21M	22.1M	318.77K	+35.71%
Mar 31, 2024	ECOR1 CAPITAL, LLC	1.96%	1.25M	22.81M	-2.24M	-64.21%
Mar 31, 2024	PARADIGM BIOCAPITAL ADVISORS LP	3.84%	2.45M	44.62M	2.45M	+100.00%
Mar 31, 2024	BAKER BROS. ADVISORS LP	9.16%	5.84M	106.52M	2.73M	+87.62%
Mar 31, 2024	RA CAPITAL MANAGEMENT, L.P.	13.98%	8.91M	162.5M	8.91M	+100.00%
Mar 31, 2024	FOX RUN MANAGEMENT, L.L.C.	0.02%	10.81K	197.25K	10.81K	+100.00%
Mar 31, 2024	STRS OHIO	0.02%	12.6K	229K	12.6K	+100.00%
Mar 31, 2024	ENTROPY TECHNOLOGIES, LP	0.02%	12.67K	231.01K	12.67K	+100.00%
Mar 31, 2024	XTX TOPCO LTD	0.02%	14.05K	256.25K	-3.09K	-18.05%
Mar 31, 2024	ENTRYPOINT CAPITAL, LLC	0.02%	14.22K	259.3K	496	+3.62%
Mar 31, 2024	Y-INTERCEPT (HONG KONG) LTD	0.02%	14.9K	271.83K	14.9K	+100.00%
Mar 31, 2024	CASTLEVIEW PARTNERS, LLC	0.03%	16.2K	295.56K	16.2K	+100.00%
Mar 31, 2024	STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	0.03%	16.65K	111.06K	-220	-1.30%
Mar 31, 2024	PRINCIPAL FINANCIAL GROUP INC	0.03%	16.77K	305.79K	365	+2.23%
Mar 31, 2024	PROSHARE ADVISORS LLC	0.03%	16.89K	307.98K	5.75K	+51.61%
Mar 31, 2024	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.03%	17.32K	152.31K	-3.51K	-16.86%
Mar 31, 2024	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.03%	17.88K	326K	10.54K	+143.68%
Mar 31, 2024	DENALI ADVISORS LLC	0.03%	19.2K	350.21K	19.2K	+100.00%
Mar 31, 2024	STATE OF WISCONSIN INVESTMENT BOARD	0.03%	19.6K	357.52K	19.6K	+100.00%
Mar 31, 2024	FRANKLIN RESOURCES INC	0.03%	20.01K	364.89K	20.01K	+100.00%
Mar 31, 2024	CREDIT SUISSE AG/	0.03%	20.17K	367.83K	2.87K	+16.57%
Mar 31, 2024	WELLS FARGO & COMPANY/MN	0.03%	20.43K	372.66K	7.26K	+55.06%
Mar 31, 2024	INVESCO LTD.	0.03%	21.15K	385.7K	4.62K	+27.94%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.04%	26.87K	490.11K	26.87K	+100.00%
Mar 31, 2024	AMERICAN INTERNATIONAL GROUP, INC.	0.04%	28.42K	518.34K	7.15K	+33.62%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.04%	28.49K	519.68M	11.83K	+71.05%
Mar 31, 2024	METLIFE INVESTMENT MANAGEMENT, LLC	0.05%	29.94K	546.01K	6.58K	+28.17%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.05%	30.58K	557.78K	13.32K	+77.19%
Mar 31, 2024	CITIGROUP INC	0.06%	36.94K	673.86K	29.68K	+408.80%
Mar 31, 2024	JPMORGAN CHASE & CO	0.07%	42.83K	781.27K	2.77K	+6.91%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.07%	45.4K	828K	-19.3K	-29.83%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.09%	56.1K	1.02M	18.68K	+49.92%
Mar 31, 2024	LIGHTHOUSE INVESTMENT PARTNERS, LLC	0.1%	60.88K	1.11M	60.88K	+100.00%
Mar 31, 2024	ALPS ADVISORS INC	0.1%	65.67K	1.2M	22.45K	+51.93%
Mar 31, 2024	QUANTUM PRIVATE WEALTH, LLC	0.1%	66.67K	1.22M	3.46K	+5.47%
Mar 31, 2024	SWISS NATIONAL BANK	0.11%	67.3K	1.23M	17.2K	+34.33%
Mar 31, 2024	NEW YORK STATE COMMON RETIREMENT FUND	0.11%	68.7K	1.25M	-2K	-2.82%
Mar 31, 2024	UBS GROUP AG	0.12%	74.12K	1.35M	74.12K	+100.00%
Mar 31, 2024	GSA CAPITAL PARTNERS LLP	0.12%	74.51K	1.36M	21.85K	+41.49%
Mar 31, 2024	DEKABANK DEUTSCHE GIROZENTRALE	0.13%	80K	1.44M	0	0
Mar 31, 2024	BARCLAYS PLC	0.14%	87.24K	1.59M	-691.67K	-88.80%
Mar 31, 2024	TWO SIGMA ADVISERS, LP	0.15%	92.4K	1.69M	51.5K	+125.92%
Mar 31, 2024	CUBIST SYSTEMATIC STRATEGIES, LLC	0.16%	103.21K	1.88M	101.48K	+5,869.23%
Dec 31, 2023	ECOR1 CAPITAL, LLC	5.5%	3.49M	38.22M	0	0
Dec 31, 2023	CITADEL ADVISORS LLC	4.07%	2.59M	28.29M	-181.51K	-6.56%
Dec 31, 2023	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	4.2%	2.67M	29.18M	1.82M	+214.15%
Dec 31, 2023	BAKER BROS. ADVISORS LP	4.91%	3.11M	34.05M	2.06M	+196.54%
Dec 31, 2023	BLACKROCK INC.	5.21%	3.31M	36.18M	321.27K	+10.76%
Dec 31, 2023	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	6.2%	3.93M	43.03M	0	0
Dec 31, 2023	NOVO HOLDINGS A/S	9.57%	6.07M	66.42M	0	0
Dec 31, 2023	VIKING GLOBAL INVESTORS LP	9.71%	6.16M	67.38M	0	0
Dec 31, 2023	FMR LLC	10.23%	6.49M	71.03M	89.67K	+1.40%
Dec 31, 2023	ORBIMED ADVISORS LLC	22.96%	14.57M	159.36M	0	0
Dec 31, 2023	DEKABANK DEUTSCHE GIROZENTRALE	0.13%	80K	920K	0	0
Dec 31, 2023	PALE FIRE CAPITAL SE	0.16%	98.45K	1.08M	82.8K	+529.27%
Dec 31, 2023	UBS OCONNOR LLC	0.18%	114.69K	1.25M	-25.17K	-18.00%
Dec 31, 2023	PRICE T ROWE ASSOCIATES INC /MD/	0.2%	126.07K	1.38M	367	+0.29%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	0.21%	131.36K	1.44M	95.46K	+265.96%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.23%	146.17K	1.6M	-114	-0.08%
Dec 31, 2023	ABRDN PLC	0.24%	150.42K	1.65M	150.42K	+100.00%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.24%	153.29K	1.68M	806	+0.53%
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	0.27%	169.54K	1.85M	111.98K	+194.53%
Dec 31, 2023	MORGAN STANLEY	0.35%	225.18K	2.46M	152.11K	+208.16%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	0.41%	262.24K	2.87M	87.32K	+49.92%
Dec 31, 2023	IKARIAN CAPITAL, LLC	0.43%	270K	2.95M	270K	+100.00%
Dec 31, 2023	CANDRIAM S.C.A.	0.49%	308K	3.37M	10K	+3.36%
Dec 31, 2023	SCHONFELD STRATEGIC ADVISORS LLC	0.5%	319.1K	3.49M	202.2K	+172.97%
Dec 31, 2023	VONTOBEL HOLDING LTD.	0.52%	327.8K	3.59M	327.8K	+100.00%
Dec 31, 2023	SECTORAL ASSET MANAGEMENT INC	0.52%	327.8K	3.59M	327.8K	+100.00%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.52%	331.06K	3.62M	200	+0.06%
Dec 31, 2023	WELLINGTON MANAGEMENT GROUP LLP	0.54%	340.91K	3.73M	340.91K	+100.00%
Dec 31, 2023	KENNEDY CAPITAL MANAGEMENT LLC	0.54%	342.86K	3.75M	342.86K	+100.00%
Dec 31, 2023	NORTHERN TRUST CORP	0.57%	363.24K	3.97M	18.33K	+5.31%
Dec 31, 2023	DRIEHAUS CAPITAL MANAGEMENT LLC	0.62%	395.07K	4.32M	395.07K	+100.00%
Dec 31, 2023	WOODLINE PARTNERS LP	0.64%	404.21K	4.42M	44.12K	+12.25%
Dec 31, 2023	DAFNA CAPITAL MANAGEMENT LLC	0.71%	449.38K	4.92M	-70K	-13.48%
Dec 31, 2023	POINT72 ASSET MANAGEMENT, L.P.	0.79%	501.26K	5.48M	501.26K	+100.00%
Dec 31, 2023	PERCEPTIVE ADVISORS LLC	0.88%	555.56K	6.08M	555.56K	+100.00%
Dec 31, 2023	PARKMAN HEALTHCARE PARTNERS LLC	1.03%	651.63K	7.13M	178.31K	+37.67%
Dec 31, 2023	OPALEYE MANAGEMENT INC.	1.1%	699K	7.65M	-176.41K	-20.15%
Dec 31, 2023	AMERICAN CENTURY COMPANIES INC	1.21%	770.45K	8.43M	242.61K	+45.96%
Dec 31, 2023	BARCLAYS PLC	1.23%	778.92K	8.52M	760.64K	+4,161.26%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	1.39%	881.9K	9.65M	-65.9K	-6.95%
Dec 31, 2023	STATE STREET CORP	1.41%	892.71K	9.77M	104.45K	+13.25%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.49%	947.05K	10.36M	55.28K	+6.20%
Dec 31, 2023	LOGOS GLOBAL MANAGEMENT LP	1.5%	950K	10.39M	950K	+100.00%
Dec 31, 2023	GRANAHAN INVESTMENT MANAGEMENT, LLC	1.69%	1.07M	11.76M	135.78K	+14.46%
Dec 31, 2023	HUDSON BAY CAPITAL MANAGEMENT LP	1.87%	1.19M	13M	1.19M	+100.00%
Dec 31, 2023	JANUS HENDERSON GROUP PLC	1.91%	1.22M	13.25M	94.25K	+8.41%
Dec 31, 2023	NEW LEAF VENTURE PARTNERS, L.L.C.	2.45%	1.55M	17M	0	0
Dec 31, 2023	VANGUARD GROUP INC	3.35%	2.13M	23.25M	60.96K	+2.95%
Dec 31, 2023	DEEP TRACK CAPITAL, LP	4%	2.54M	27.76M	-212.82K	-7.74%
Dec 31, 2023	CORMORANT ASSET MANAGEMENT, LP	4.02%	2.55M	27.92M	-394.9K	-13.40%

Insiders

Among the EWTX insiders holding of 0.44% of the stake in company, ORBIMED GENESIS GP LLC, , holds the largest shares of 13.5M. NOVO HOLDINGS A/S, 10 percent owner, is the second largest EWTX insider with ownership of 6.07M shares. FLYNN JAMES E, 10 percent owner, stands third with possession of 3.93M shares of that stake.

Insiders	Designation	Shares Held
ORBIMED GENESIS GP LLC		13.5M
NOVO HOLDINGS A/S	10 percent owner	6.07M
FLYNN JAMES E	10 percent owner	3.93M
ORBIMED ADVISORS LLC		443.79K
THOMPSON PETER A.		443.79K
CARRUTHERS R MICHAEL	Chief Financial Officer	86.16K
KOCH KEVIN	President and CEO	30.62K
DONOVAN JOANNE M.	CMO	25.36K
FOX JONATHAN C	director	23.7K
DERAKHSHAN BEHRAD	Chief Business Officer	23.65K
RUSSELL ALAN J	Chief Scientific Officer	23.4K
ROOT JONATHAN D	director	15.63K
MOORE JOHN R	General Counsel	10.21K
SEMIGRAN MARC	Chief Development Officer	6.72K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Nov 12, 2025	RUSSELL ALAN J	SALE	21.12	100K	2.11M	23.4K
Nov 11, 2025	FOX JONATHAN C	PURCHASE	18.64	10.7K	199.4K	23.7K
Aug 26, 2025	RUSSELL ALAN J	SALE	14.60	100K	1.46M	23.4K
Aug 12, 2025	MOORE JOHN R	SALE	13.39	2.1K	28.1K	10.21K
Aug 12, 2025	DONOVAN JOANNE M.	SALE	13.39	2.86K	38.33K	25.36K
Aug 12, 2025	KOCH KEVIN	SALE	13.39	7.97K	106.76K	30.62K
Aug 12, 2025	RUSSELL ALAN J	SALE	13.39	1.91K	25.54K	23.4K
Aug 12, 2025	CARRUTHERS R MICHAEL	SALE	13.39	1.43K	19.12K	86.16K
Aug 12, 2025	DERAKHSHAN BEHRAD	SALE	13.39	2.49K	33.36K	23.65K
May 02, 2025	CARRUTHERS R MICHAEL	SALE	16.45	1.31K	21.62K	81.01K
May 02, 2025	RUSSELL ALAN J	SALE	16.45	1.55K	25.52K	18.52K
May 02, 2025	MOORE JOHN R	SALE	16.45	1.93K	31.76K	6.53K
May 02, 2025	KOCH KEVIN	SALE	16.45	4.28K	70.36K	20.62K
May 02, 2025	DONOVAN JOANNE M.	SALE	16.45	5.19K	85.35K	21.59K
May 02, 2025	DERAKHSHAN BEHRAD	SALE	16.45	1.69K	27.82K	20.36K
Apr 03, 2025	THOMPSON PETER A.	PURCHASE	20.13	124.19K	2.5M	443.79K
Apr 03, 2025	ORBIMED ADVISORS LLC	PURCHASE	20.13	124.19K	2.5M	443.79K
Mar 07, 2025	KOCH KEVIN	SALE	30.00	100	3K	14.48K
Mar 07, 2025	RUSSELL ALAN J	SALE	30.02	200	6K	14.86K
Feb 06, 2025	RUSSELL ALAN J	SALE	30.13	1.2K	36.15K	14.86K
Feb 06, 2025	KOCH KEVIN	SALE	31.13	900	28.02K	14.48K
Feb 05, 2025	DERAKHSHAN BEHRAD	SALE	30.03	10K	300.3K	16.84K
Feb 05, 2025	KOCH KEVIN	SALE	30.03	8.64K	259.3K	14.48K
Feb 05, 2025	RUSSELL ALAN J	SALE	30.02	8.02K	240.62K	14.86K
Jan 28, 2025	DONOVAN JOANNE M.	SALE	27.63	25K	690.66K	16.36K
Dec 30, 2024	RUSSELL ALAN J	SALE	27.37	100K	2.74M	14.86K
Dec 24, 2024	SEMIGRAN MARC	SALE	30.08	1.73K	52.01K	6.72K
Sep 23, 2024	MOORE JOHN R	SALE	27.63	20.92K	578.06K	3.25K
Sep 20, 2024	MOORE JOHN R	SALE	28.37	50K	1.42M	3.25K
Sep 20, 2024	RUSSELL ALAN J	SALE	29.51	815	24.05K	12.72K
Sep 20, 2024	CARRUTHERS R MICHAEL	SALE	28.55	50K	1.43M	6.9K
Sep 20, 2024	DERAKHSHAN BEHRAD	SALE	29.03	42.07K	1.22M	15.12K
Sep 20, 2024	DONOVAN JOANNE M.	SALE	28.29	7.16K	202.6K	14.54K
May 02, 2024	DERAKHSHAN BEHRAD	SALE	18.91	1.72K	32.49K	13.42K
May 02, 2024	RUSSELL ALAN J	SALE	18.91	1.58K	29.8K	7.24K
May 02, 2024	DONOVAN JOANNE M.	SALE	18.91	3.68K	69.63K	19.9K
May 02, 2024	CARRUTHERS R MICHAEL	SALE	18.91	2.16K	40.79K	35.23K
May 02, 2024	MOORE JOHN R	SALE	18.91	1.96K	36.99K	3.25K
May 02, 2024	KOCH KEVIN	SALE	18.91	3.15K	59.6K	14.48K
Feb 09, 2024	MOORE JOHN R	SALE	20.01	8.03K	160.66K	0
Feb 09, 2024	DERAKHSHAN BEHRAD	SALE	20.04	4.8K	96.21K	7.02K
Feb 08, 2024	DERAKHSHAN BEHRAD	SALE	20.01	4.6K	92.05K	7.02K
Feb 08, 2024	MOORE JOHN R	SALE	20.01	3.81K	76.28K	0
Feb 07, 2024	MOORE JOHN R	SALE	20.00	17.99K	359.86K	0
Feb 07, 2024	DERAKHSHAN BEHRAD	SALE	20.00	600	12K	7.02K
Jan 23, 2024	ORBIMED ADVISORS LLC	PURCHASE	11.00	454.55K	5M	14.44M
Jan 23, 2024	THOMPSON PETER A.	PURCHASE	11.00	454.55K	5M	14.44M
Jan 23, 2024	CARRUTHERS R MICHAEL	SALE	15.78	90K	1.42M	29.02K
Dec 27, 2023	MOORE JOHN R	SALE	10.50	8.5K	89.22K	0
Dec 26, 2023	FOX JONATHAN C	PURCHASE	9.30	10.86K	100.96K	10.86K
Dec 26, 2023	RUSSELL ALAN J	SALE	9.33	172.59K	1.61M	3.61K
May 02, 2023	DERAKHSHAN BEHRAD	SALE	8.90	1.75K	15.56K	7.02K
May 02, 2023	RUSSELL ALAN J	SALE	8.90	1.6K	14.27K	176.19K
May 02, 2023	KOCH KEVIN	SALE	8.90	3.2K	28.52K	7.21K
May 02, 2023	DONOVAN JOANNE M.	SALE	8.90	3.25K	28.98K	9.96K
May 02, 2023	MOORE JOHN R	SALE	8.90	1.9K	16.89K	6.57K
May 02, 2023	CARRUTHERS R MICHAEL	SALE	8.90	1.34K	11.9K	16.13K
Oct 03, 2022	MOORE JOHN R	SALE	9.76	4.73K	46.15K	3K
Sep 16, 2022	ORBIMED ADVISORS LLC	PURCHASE	10.32	484.5K	5M	13.98M
Sep 16, 2022	THOMPSON PETER A.	PURCHASE	10.32	484.5K	5M	13.98M
Sep 14, 2022	NOVO HOLDINGS A/S	PURCHASE	10.32	484.5K	5M	6.07M
Sep 06, 2022	MOORE JOHN R	SALE	10.99	2.35K	25.84K	3K
Aug 03, 2022	MOORE JOHN R	SALE	9.31	9.23K	85.92K	3K
Jul 05, 2022	MOORE JOHN R	SALE	8.35	8.19K	68.33K	3K
Jun 16, 2022	MOORE JOHN R	SALE	7.29	31.08K	226.7K	3K
Jun 13, 2022	MOORE JOHN R	SALE	6.11	18.08K	110.45K	3K
Jun 08, 2022	MOORE JOHN R	SALE	6.05	7.13K	43.12K	3K
Jun 03, 2022	MOORE JOHN R	SALE	6.61	17.15K	113.28K	3K
May 18, 2022	THOMPSON PETER A.	PURCHASE	7.21	138K	994.98K	13.5M
May 18, 2022	ORBIMED GENESIS GP LLC	PURCHASE	7.21	138K	994.98K	13.5M
May 18, 2022	ORBIMED ADVISORS LLC	PURCHASE	7.21	138K	994.98K	13.5M
May 16, 2022	MOORE JOHN R	SALE	7.42	10.8K	80.15K	3K
Nov 15, 2021	RUSSELL ALAN J	SALE	19.61	38	745.18	0
Nov 12, 2021	RUSSELL ALAN J	SALE	19.51	8.56K	167.07K	479
Nov 11, 2021	RUSSELL ALAN J	SALE	20.43	3.68K	75.2K	9.04K
Nov 10, 2021	RUSSELL ALAN J	SALE	20.21	580	11.72K	28.32K
Nov 09, 2021	RUSSELL ALAN J	SALE	20.30	12.71K	258.03K	40.64K
Nov 08, 2021	RUSSELL ALAN J	SALE	20.16	9.02K	181.82K	70.22K
Nov 05, 2021	RUSSELL ALAN J	SALE	19.62	13.04K	255.78K	79.24K
Nov 04, 2021	RUSSELL ALAN J	SALE	19.76	7.39K	146.09K	92.28K
Nov 03, 2021	RUSSELL ALAN J	SALE	19.42	1.12K	21.73K	99.67K
Nov 02, 2021	RUSSELL ALAN J	SALE	17.43	17.52K	305.36K	125.85K
Nov 01, 2021	RUSSELL ALAN J	SALE	18.02	469	8.45K	143.37K
Oct 15, 2021	RUSSELL ALAN J	SALE	18.00	126	2.27K	143.84K
Oct 14, 2021	RUSSELL ALAN J	SALE	18.18	5.75K	104.52K	145.28K
Oct 11, 2021	RUSSELL ALAN J	SALE	18.02	1.27K	22.89K	151.02K
Oct 08, 2021	RUSSELL ALAN J	SALE	18.15	5.9K	107.12K	152.29K
Oct 07, 2021	RUSSELL ALAN J	SALE	18.56	13.02K	241.61K	158.2K
Oct 06, 2021	RUSSELL ALAN J	SALE	18.03	2.11K	38.01K	171.21K
Oct 05, 2021	RUSSELL ALAN J	SALE	18.26	5.4K	98.68K	173.32K
Oct 04, 2021	RUSSELL ALAN J	SALE	18.00	100	1.8K	178.73K
Oct 01, 2021	RUSSELL ALAN J	SALE	18.00	274	4.93K	178.83K
Sep 29, 2021	RUSSELL ALAN J	SALE	17.47	618	10.8K	179.1K
Sep 28, 2021	RUSSELL ALAN J	SALE	17.30	14.61K	252.75K	190.94K
Sep 27, 2021	RUSSELL ALAN J	SALE	18.48	17	314.16	205.55K
Sep 24, 2021	RUSSELL ALAN J	SALE	18.16	20.1K	365.02K	217.17K
Sep 23, 2021	RUSSELL ALAN J	SALE	19.42	5.07K	98.5K	237.27K
Mar 30, 2021	NOVO HOLDINGS A/S	PURCHASE	16.00	625K	10M	5.59M
Mar 30, 2021	FLYNN JAMES E	PURCHASE	16.00	625K	10M	3.93M
Mar 30, 2021	ROOT JONATHAN D	PURCHASE	16.00	15.63K	250K	15.63K
Mar 30, 2021	ORBIMED ADVISORS LLC	PURCHASE	16.00	46.88K	750K	319.6K
Mar 30, 2021	THOMPSON PETER A.	PURCHASE	16.00	46.88K	750K	319.6K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE10.7K1

SALES218.76K8

NET SHARES-208.06K7

SHARES HELD269.9K9

% NET SHARES-177.09%-22.22%

Frequently Asked Questions