How many institutions own ETNB stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own ETNB shares is 258, representing 111.87% of the company's common stock.

Who are the major shareholders selling 89bio, Inc. stock?

ERSTE ASSET MANAGEMENT GMBH, in the last quarter, reduced its stake in ETNB by -5.66% restricting it's holding to 833 thousand shares of worth nearly $12.25M. NUVEEN, LLC also lessened -37.36% of the ETNB shares from its portfolio, reducing its holding to 400.15 thousand shares of worth $5.88M. RAYMOND JAMES FINANCIAL INC also shunned ETNB shares holding by -26.91% last quarter which brought its holding to 417.76 thousand shares worth $6.14M.

Investors who are buying ETNB stock?

As per its latest 13F filing, SUPERSTRING CAPITAL MANAGEMENT LP increased its stake in ETNB by 81.12% in the last quarter. The institutional holder raised its holding to 384.65 thousand shares having worth more than $5.65M. EVERSEPT PARTNERS, LP also added 66.3% more shares of ETNB to its portfolio, raising its holding to 392.44 thousand shares of worth $5.77M. GROUPE LA FRANCAISE also increased its ETNB shares holding by 100% which brought its holding to 400 thousand shares worth $5.88M.

ETNB's major insiders: who are they?

The insider with the most stakes in ETNB is RA CAPITAL MANAGEMENT, L.P. , at the company. Additionally, ETNB stock is highly held by Shah Rajeev M. and 10 percent owner Longitude Capital Partners III, LLC among others.

Did an insider recently sell ETNB stock?

Company executives, directors, and other insiders own 0.54% percent of 89bio, Inc.'s stock. Within the last six months, there have been 1 transaction(s) in which ETNB insiders have sold stock, totaling 10.46K shares. Insiders that have sold shares include LE-NGUYEN QUOC, PALEKAR ROHAN, and LAPORTE KATHLEEN.

Which insider recently purchased ETNB stock?

There have been 0 transaction(s) during the past 6-months in which 89bio, Inc. insiders have bought stock, totalling 0 shares

How much of ETNB does insiders own?

Around 309.36K 89bio, Inc. shares are held by insiders, which represents about 0.54% of ETNB stock.

Who is the insider with the largest stake?

ETNB , RA CAPITAL MANAGEMENT, L.P. holds the largest portfolio of the company's shares. ETNB shares owned by RA total nearly 19.55 million.

Which institution holds the most shares in ETNB?

SUPERSTRING CAPITAL MANAGEMENT LP is the largest institutional owner in ETNB which holds 384.65 thousand shares worth $5.65M or 0.24% of the total ETNB shares outstanding followed by EVERSEPT PARTNERS, LP with ownership of 392.44 thousand shares representing 0.25% of the ETNB ownership. GROUPE LA FRANCAISE is the third largest stakeholder with 400 thousand shares or 0.25% of the ownership worth more than $5.88M.

Is 89bio, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the ETNB is concerned, it is a stock which is optionable.

Is there a short position on ETNB's shares?

Number of ETNB shares short is 15.79M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding ETNB shares are there?

As of today, 148.31M shares of ETNB are outstanding.

Is there many float in ETNB stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, ETNB has 103.73M shares in float.

ETNB short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for ETNB is 11.3.

89bio (ETNB) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableNo

OptionableYes

Short Percent Of Outstanding Shares10.64

Short Percent Of Float14.73

Shares Outstanding148.31M

Shares Float103.73M

Shares Short15.79M

Short Ratio11.3

14.73%

Short % of Float

10.64%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

0.54% Percentage of Shares held by All Insiders

111.87% Percentage of Shares held by All Institutions

112.48% Percentage of Float held by Institutions

258

Number of Institutions Holding Shares

Institutional Ownership

About 111.87% of ETNB shares are held by financial institutions. SUPERSTRING CAPITAL MANAGEMENT LP is the top corporate investor, holding 384.65K shares valued at $5.65M. A 0.24% stake in 89bio, Inc. is owned by the company. EVERSEPT PARTNERS, LP owns 392.44K shares valued at $5.77M, which translates its holding of 0.25% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	SUPERSTRING CAPITAL MANAGEMENT LP	0.24%	384.65K	5.65M	172.28K	+81.12%
Sep 30, 2025	EVERSEPT PARTNERS, LP	0.25%	392.44K	5.77M	156.45K	+66.30%
Sep 30, 2025	GROUPE LA FRANCAISE	0.25%	400K	5.88M	400K	+100.00%
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	12.6%	19.89M	292.38M	0	0
Sep 30, 2025	ERSTE ASSET MANAGEMENT GMBH	0.53%	833K	12.25M	-50K	-5.66%
Sep 30, 2025	LMR PARTNERS LLP	0.63%	1M	14.7M	1M	+100.00%
Sep 30, 2025	NUVEEN, LLC	0.25%	400.15K	5.88M	-238.67K	-37.36%
Sep 30, 2025	RAYMOND JAMES FINANCIAL INC	0.26%	417.76K	6.14M	-153.85K	-26.91%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.46%	725.82K	10.67M	-236.65K	-24.59%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.52%	820.62K	12.06M	-429.33K	-34.35%
Sep 30, 2025	CSS LLC/IL	0.26%	409.57K	6.02M	409.57K	+100.00%
Sep 30, 2025	YAKIRA CAPITAL MANAGEMENT, INC.	0.16%	251.99K	3.7M	251.99K	+100.00%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.19%	293.94K	4.32M	144.92K	+97.25%
Sep 30, 2025	JBF CAPITAL, INC.	0.47%	735K	50K	735K	+100.00%
Sep 30, 2025	JANUS HENDERSON GROUP PLC	3.41%	5.38M	79.06M	-15.41M	-74.13%
Sep 30, 2025	GLAZER CAPITAL, LLC	3.57%	5.64M	82.86M	5.64M	+100.00%
Sep 30, 2025	AVORO CAPITAL ADVISORS LLC	4.05%	6.39M	93.9M	-362.21K	-5.37%
Sep 30, 2025	VANGUARD GROUP INC	5.1%	8.05M	118.39M	-188.7K	-2.29%
Sep 30, 2025	DEEP TRACK CAPITAL, LP	5.93%	9.36M	137.54M	-143.83K	-1.51%
Sep 30, 2025	EMERALD ADVISERS, LLC	0.34%	535.15K	7.87M	-1.31M	-70.98%
Sep 30, 2025	GABELLI & CO INVESTMENT ADVISERS, INC.	0.26%	417.85K	6.14M	417.85K	+100.00%
Sep 30, 2025	JANE STREET GROUP, LLC	0.27%	428.72K	6.3M	428.72K	+100.00%
Sep 30, 2025	GABELLI FUNDS LLC	0.27%	434.03K	6.38M	434.03K	+100.00%
Sep 30, 2025	MORGAN STANLEY	0.28%	444.77K	6.54M	-1.74M	-79.64%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.32%	510.5K	7.5M	-2.9K	-0.56%
Sep 30, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.32%	512.05K	7.53M	-633.76K	-55.31%
Sep 30, 2025	BARCLAYS PLC	0.33%	527.07K	7.75M	38.36K	+7.85%
Sep 30, 2025	ALPINE ASSOCIATES MANAGEMENT INC.	0.34%	529.8K	7.79M	529.8K	+100.00%
Sep 30, 2025	OMERS ADMINISTRATION CORP	0.36%	575.1K	8.45M	575.1K	+100.00%
Sep 30, 2025	CREDIT INDUSTRIEL ET COMMERCIAL	0.38%	600K	8.82M	600K	+100.00%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.64%	1M	14.75M	-60.9K	-5.72%
Sep 30, 2025	NORTHERN TRUST CORP	0.71%	1.13M	16.55M	-6.65K	-0.59%
Sep 30, 2025	NEWTYN MANAGEMENT, LLC	0.51%	800K	11.76M	600K	+300.00%
Sep 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	1.34%	2.11M	31.06M	1.24M	+141.23%
Sep 30, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	1.38%	2.17M	31.93M	1.95M	+862.34%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	1.02%	1.61M	23.62M	423.56K	+35.80%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.96%	3.09M	45.46M	-18.96K	-0.61%
Sep 30, 2025	DEUTSCHE BANK AG\	2.22%	3.5M	51.44M	3.41M	+3,941.65%
Sep 30, 2025	STATE STREET CORP	3.35%	5.29M	77.71M	1.04M	+24.39%
Sep 30, 2025	SUVRETTA CAPITAL MANAGEMENT, LLC	5.24%	8.28M	121.72M	-5.93M	-41.73%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	5.76%	9.1M	133.73M	7.13M	+362.04%
Sep 30, 2025	TIG ADVISORS, LLC	1.39%	2.19M	32.14M	2.19M	+100.00%
Sep 30, 2025	KRYGER CAPITAL LTD	1.49%	2.35M	34.55M	2.35M	+100.00%
Sep 30, 2025	SYQUANT CAPITAL SAS	1.64%	2.59M	38.13M	2.59M	+100.00%
Sep 30, 2025	WESTFIELD CAPITAL MANAGEMENT CO LP	2.08%	3.29M	48.38M	-79.45K	-2.36%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.41%	651.87K	9.58M	322.01K	+97.62%
Sep 30, 2025	UBS GROUP AG	0.42%	666.84K	9.8M	317.4K	+90.83%
Sep 30, 2025	REDMILE GROUP, LLC	0.93%	1.47M	21.66M	-72.07K	-4.66%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.02%	1.62M	23.77M	363.7K	+29.02%
Sep 30, 2025	GILLILAND JETER WEALTH MANAGEMENT LLC	0.04%	60.5K	889.34K	7.75K	+14.69%
Sep 30, 2025	MINT TOWER CAPITAL MANAGEMENT B.V.	0.04%	70K	1.03M	70K	+100.00%
Sep 30, 2025	JPMORGAN CHASE & CO	0.05%	71.18K	1.05M	-8.4K	-10.55%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.05%	74.66K	1.1M	0	0
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.05%	82.83K	1.22M	-22.34K	-21.24%
Sep 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.06%	90K	1.1M	0	0
Sep 30, 2025	PANAGORA ASSET MANAGEMENT INC	0.06%	90.25K	1.33M	-239.63K	-72.64%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.06%	90.5K	1.33M	15.12K	+20.06%
Sep 30, 2025	SIMPLEX TRADING, LLC	0.07%	108.25K	1.59M	99.05K	+1,077.47%
Sep 30, 2025	CITIGROUP INC	0.09%	144.44K	2.12M	-71.89K	-33.23%
Sep 30, 2025	QUINN OPPORTUNITY PARTNERS LLC	0.1%	150K	2.21M	150K	+100.00%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.69%	1.09M	16.09M	1.09M	+100.00%
Sep 30, 2025	WEISS ASSET MANAGEMENT LP	0.89%	1.4M	20.58M	1.4M	+100.00%
Sep 30, 2025	SANDERS MORRIS HARRIS LLC	0.1%	163.91K	2.41M	163.91K	+100.00%
Sep 30, 2025	INVESCO LTD.	0.1%	165.42K	2.43M	13.73K	+9.05%
Sep 30, 2025	RHUMBLINE ADVISERS	0.12%	189.82K	2.79M	-4K	-2.06%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.12%	189.84K	2.79M	67.48K	+55.16%
Sep 30, 2025	ORCHARD CAPITAL MANAGEMENT, LLC	0.13%	204.11K	3M	6K	+3.03%
Sep 30, 2025	SWISS NATIONAL BANK	0.13%	212.2K	3.12M	17K	+8.71%
Sep 30, 2025	ROYCE & ASSOCIATES LP	0.14%	226.06K	3.32M	0	0
Sep 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.15%	242.56K	3.57M	-11.7K	-4.60%
Sep 30, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.15%	242.72K	3.57M	-1.93M	-88.82%
Sep 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.16%	248.5K	3.65M	36.54K	+17.24%
Sep 30, 2025	BLACKROCK, INC.	6.53%	10.32M	151.65M	-253.03K	-2.39%
Sep 30, 2025	PENTWATER CAPITAL MANAGEMENT LP	7.44%	11.75M	172.73M	11.75M	+100.00%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.22%	349.68K	5.14M	107	+0.03%
Sep 30, 2025	VIVO CAPITAL, LLC	0.24%	376.8K	5.54M	0	0
Jun 30, 2025	ATOM INVESTORS LP	0.13%	205.95K	2.02M	112.78K	+121.05%
Jun 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.13%	211.96K	2.08M	71.65K	+51.07%
Jun 30, 2025	SPHERA FUNDS MANAGEMENT LTD.	0.13%	205.68K	2.02M	-412.67K	-66.74%
Jun 30, 2025	NEWTYN MANAGEMENT, LLC	0.13%	200K	1.96M	0	0
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.33%	513.4K	5.04M	9.1K	+1.80%
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	12.6%	19.89M	195.32M	0	0
Jun 30, 2025	SUVRETTA CAPITAL MANAGEMENT, LLC	9%	14.21M	139.54M	-125.24K	-0.87%
Jun 30, 2025	BLACKROCK, INC.	6.69%	10.57M	103.79M	494.08K	+4.90%
Jun 30, 2025	SUSQUEHANNA PORTFOLIO STRATEGIES, LLC	0.08%	126.51K	1.24M	102.41K	+424.93%
Jun 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.08%	122.35K	1.2M	-14.89K	-10.85%
Jun 30, 2025	ALGERT GLOBAL LLC	0.08%	121.98K	1.2M	-65.01K	-34.77%
Jun 30, 2025	VERITION FUND MANAGEMENT LLC	0.08%	121.16K	1.19M	121.16K	+100.00%
Jun 30, 2025	J. GOLDMAN & CO LP	0.06%	96.34K	946.05K	-46.23K	-32.42%
Jun 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.06%	90K	1.1M	0	0
Jun 30, 2025	WESTFIELD CAPITAL MANAGEMENT CO LP	2.13%	3.37M	33.1M	-523.92K	-13.45%
Jun 30, 2025	ORCHARD CAPITAL MANAGEMENT, LLC	0.13%	198.12K	1.95M	-266.24K	-57.33%
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	0.09%	149.02K	1.46M	-36.28K	-19.58%
Jun 30, 2025	STATE OF WISCONSIN INVESTMENT BOARD	0.09%	148K	1.45M	29.3K	+24.68%
Jun 30, 2025	DEEP TRACK CAPITAL, LP	6.02%	9.5M	93.29M	183.67K	+1.97%
Jun 30, 2025		0.32%	500K	4.91M	0	0
Jun 30, 2025	FMR LLC	0.36%	569.01K	5.59M	-121.01K	-17.54%
Jun 30, 2025	RAYMOND JAMES FINANCIAL INC	0.36%	571.6K	5.61M	189.31K	+49.52%
Jun 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.37%	576.97K	5.67M	-275.25K	-32.30%
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.39%	619.6K	6.08M	539.9K	+677.42%
Jun 30, 2025	INFINITUM ASSET MANAGEMENT, LLC	0.32%	500K	4.91M	0	0
Jun 30, 2025	NUVEEN, LLC	0.4%	638.83K	6.27M	-397.13K	-38.33%
Jun 30, 2025	CAPTION MANAGEMENT, LLC	0.42%	665.6K	6.54M	308.8K	+86.55%
Jun 30, 2025	ERSTE ASSET MANAGEMENT GMBH	0.56%	883K	8.68M	0	0
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.22%	349.57K	3.43M	39.66K	+12.80%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.23%	367.27K	3.61M	117.07K	+46.79%
Jun 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.25%	391.41K	3.84M	122.61K	+45.61%
Jun 30, 2025	BARCLAYS PLC	0.31%	488.71K	4.8M	-338.15K	-40.90%
Jun 30, 2025	WOODLINE PARTNERS LP	0.77%	1.22M	12.01M	521.91K	+74.48%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.79%	1.25M	12.27M	468K	+59.85%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.79%	1.25M	12.31M	257.64K	+25.88%
Jun 30, 2025	ASSENAGON ASSET MANAGEMENT S.A.	1.38%	2.17M	21.32M	1.74M	+406.23%
Jun 30, 2025	MORGAN STANLEY	1.38%	2.19M	21.46M	1.56M	+247.25%
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	1.44%	2.27M	22.33M	2.27M	+100.00%
Jun 30, 2025	POLAR CAPITAL HOLDINGS PLC	1.57%	2.48M	24.3M	-25K	-1.00%
Jun 30, 2025	UNIVERSITY OF WISCONSIN FOUNDATION	0.73%	1.15M	11.33M	0	0
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.75%	1.18M	11.62M	595.24K	+101.23%
Jun 30, 2025	VIVO CAPITAL, LLC	0.24%	376.8K	3.7M	0	0
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.24%	383.19K	3.76M	383.19K	+100.00%
Jun 30, 2025	CANDRIAM S.C.A.	0.49%	766.21K	7.52M	-65.61K	-7.89%
Jun 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.55%	875.98K	8.6M	71.76K	+8.92%
Jun 30, 2025	READYSTATE ASSET MANAGEMENT LP	0.57%	902.08K	8.86M	216.91K	+31.66%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.61%	962.47K	9.45M	510.02K	+112.72%
Jun 30, 2025	INTEGRAL HEALTH ASSET MANAGEMENT, LLC	0.67%	1.05M	10.31M	0	0
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.67%	1.06M	10.45M	78.2K	+7.93%
Jun 30, 2025	NORTHERN TRUST CORP	0.72%	1.13M	11.12M	46.97K	+4.33%
Jun 30, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.73%	1.15M	11.25M	62.84K	+5.80%
Jun 30, 2025	HOLOCENE ADVISORS, LP	1.94%	3.07M	30.1M	3.07M	+100.00%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.97%	3.11M	30.56M	213.33K	+7.36%
Jun 30, 2025	CITADEL ADVISORS LLC	2.43%	3.84M	37.68M	-1.25M	-24.57%
Jun 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	2.56%	4.04M	39.63M	-169.5K	-4.03%
Jun 30, 2025	STATE STREET CORP	2.69%	4.25M	41.73M	219.65K	+5.45%
Jun 30, 2025	AVORO CAPITAL ADVISORS LLC	4.28%	6.75M	66.29M	400K	+6.30%
Jun 30, 2025	VANGUARD GROUP INC	5.22%	8.24M	80.94M	1.08M	+15.06%
Jun 30, 2025	JANUS HENDERSON GROUP PLC	13.17%	20.79M	204.19M	325.46K	+1.59%
Jun 30, 2025	REDMILE GROUP, LLC	0.98%	1.55M	15.17M	-341.24K	-18.09%
Jun 30, 2025	EMERALD ADVISERS, LLC	1.17%	1.84M	18.11M	293.7K	+18.94%
Jun 30, 2025	RTW INVESTMENTS, LP	1.25%	1.97M	19.32M	0	0
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.25%	1.97M	19.34M	1.97M	+100.00%
Jun 30, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	1.29%	2.04M	20M	526.59K	+34.86%
Jun 30, 2025	APIS CAPITAL ADVISORS, LLC	0.2%	322K	3.16M	7K	+2.22%
Jun 30, 2025	TREXQUANT INVESTMENT LP	0.18%	281.03K	2.76M	181.84K	+183.34%
Jun 30, 2025	DARK FOREST CAPITAL MANAGEMENT LP	0.17%	266.4K	2.62M	205.97K	+340.90%
Jun 30, 2025	ROYAL BANK OF CANADA	0.17%	260.64K	2.56M	193.95K	+290.84%
Jun 30, 2025	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.16%	255.8K	2.51M	-10.67K	-4.00%
Jun 30, 2025	EVERSEPT PARTNERS, LP	0.15%	235.99K	2.32M	-67.74K	-22.30%
Jun 30, 2025	JENNISON ASSOCIATES LLC	0.15%	234.19K	2.3M	234.19K	+100.00%
Jun 30, 2025	EXOME ASSET MANAGEMENT LLC	0.15%	233.43K	2.29M	-120.46K	-34.04%
Jun 30, 2025	ROYCE & ASSOCIATES LP	0.14%	226.06K	2.22M	8	0.00%
Jun 30, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.14%	225.7K	2.22M	-24.5K	-9.79%
Jun 30, 2025	HARBOR CAPITAL ADVISORS, INC.	0.14%	217.75K	2.14M	-97.02K	-30.82%
Jun 30, 2025	F/M INVESTMENTS LLC	0.14%	217.74K	2.14M	2.91K	+1.35%
Jun 30, 2025	SUPERSTRING CAPITAL MANAGEMENT LP	0.13%	212.38K	2.09M	103.22K	+94.56%
Mar 31, 2025	READYSTATE ASSET MANAGEMENT LP	0.47%	685.17K	4.98M	685.17K	+100.00%
Mar 31, 2025	LOGOS GLOBAL MANAGEMENT LP	1.71%	2.5M	18.18M	2.5M	+100.00%
Mar 31, 2025	POLAR CAPITAL HOLDINGS PLC	1.71%	2.5M	18.18M	2.5M	+100.00%
Mar 31, 2025	RTW INVESTMENTS, LP	1.34%	1.97M	14.3M	-5.51M	-73.69%
Mar 31, 2025	REDMILE GROUP, LLC	1.29%	1.89M	13.71M	-280.73K	-12.95%
Mar 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.58%	852.23K	6.2M	-73.17K	-7.91%
Mar 31, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.58%	844.44K	6.14M	291.7K	+52.77%
Mar 31, 2025	BARCLAYS PLC	0.56%	826.86K	6.01M	186.89K	+29.20%
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.55%	804.22K	5.85M	289.08K	+56.12%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.53%	781.95K	5.68M	423.38K	+118.07%
Mar 31, 2025	MORGAN STANLEY	0.43%	629.23K	4.57M	287.28K	+84.01%
Mar 31, 2025	RAYMOND JAMES FINANCIAL INC	0.26%	382.29K	2.78M	4.92K	+1.30%
Mar 31, 2025	CAPTION MANAGEMENT, LLC	0.24%	356.8K	2.59M	-75.3K	-17.43%
Mar 31, 2025	BECK BODE, LLC	1.24%	1.82M	13.2M	1.82M	+100.00%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.34%	504.3K	3.67M	206.6K	+69.40%
Mar 31, 2025	ORCHARD CAPITAL MANAGEMENT, LLC	0.32%	464.36K	3.38M	421.73K	+989.40%
Mar 31, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.29%	428.9K	3.12M	186.29K	+76.79%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.31%	452.45K	3.29M	-255.74K	-36.11%
Mar 31, 2025	VIVO CAPITAL, LLC	0.26%	376.8K	2.74M	376.8K	+100.00%
Mar 31, 2025	SPHERA FUNDS MANAGEMENT LTD.	0.42%	618.34K	4.5M	61.81K	+11.11%
Mar 31, 2025	LORD, ABBETT & CO. LLC	0.5%	733.4K	5.33M	733.4K	+100.00%
Mar 31, 2025	WOODLINE PARTNERS LP	0.48%	700.75K	5.09M	305.93K	+77.48%
Mar 31, 2025	FMR LLC	0.47%	690.01K	5.02M	597.85K	+648.65%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.4%	587.99K	4.28M	245.76K	+71.81%
Mar 31, 2025	PANAGORA ASSET MANAGEMENT INC	0.29%	429.39K	3.12M	314K	+272.12%
Mar 31, 2025	DEEP TRACK CAPITAL, LP	6.37%	9.32M	67.73M	2.84M	+43.81%
Mar 31, 2025	SUVRETTA CAPITAL MANAGEMENT, LLC	9.79%	14.34M	104.22M	4.13M	+40.50%
Mar 31, 2025	BLACKROCK, INC.	6.88%	10.08M	73.25M	2.19M	+27.70%
Mar 31, 2025	VANGUARD GROUP INC	4.89%	7.16M	52.08M	1.47M	+25.85%
Mar 31, 2025	AVORO CAPITAL ADVISORS LLC	4.34%	6.35M	46.16M	2.25M	+54.88%
Mar 31, 2025	CITADEL ADVISORS LLC	3.48%	5.09M	36.98M	356.98K	+7.55%
Mar 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	2.87%	4.2M	30.57M	1.2M	+39.84%
Mar 31, 2025	STATE STREET CORP	2.75%	4.03M	29.3M	1.09M	+36.84%
Mar 31, 2025	WESTFIELD CAPITAL MANAGEMENT CO LP	2.66%	3.89M	28.31M	7.95K	+0.20%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.98%	2.9M	21.07M	690.37K	+31.27%
Mar 31, 2025	EMERALD ADVISERS, LLC	1.06%	1.55M	11.27M	1.55M	+100.00%
Mar 31, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	1.03%	1.51M	10.98M	1.41M	+1,465.10%
Mar 31, 2025	NORTHERN TRUST CORP	0.74%	1.09M	7.89M	230.68K	+26.99%
Mar 31, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.74%	1.08M	7.87M	1.08M	+100.00%
Mar 31, 2025	INTEGRAL HEALTH ASSET MANAGEMENT, LLC	0.72%	1.05M	7.63M	50K	+5.00%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.68%	995.45K	7.24M	188.37K	+23.34%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.67%	985.77K	7.17M	174.95K	+21.58%
Mar 31, 2025	CANDRIAM S.C.A.	0.57%	831.82K	6.05M	-223.84K	-21.20%
Mar 31, 2025	UNIVERSITY OF WISCONSIN FOUNDATION	0.79%	1.15M	8.38M	236K	+25.73%
Mar 31, 2025	SIO CAPITAL MANAGEMENT, LLC	0.34%	500K	3.64M	500K	+100.00%
Mar 31, 2025		0.34%	500K	3.64M	500K	+100.00%
Mar 31, 2025	JANUS HENDERSON GROUP PLC	13.98%	20.46M	165.29M	3.95M	+23.91%
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	13.59%	19.89M	144.6M	5.71M	+40.31%
Mar 31, 2024	PARKMAN HEALTHCARE PARTNERS LLC	0.22%	179.9K	2.09M	-39.55K	-18.02%
Mar 31, 2024	COMERICA BANK	0.21%	171K	1.99M	15.07K	+9.66%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.21%	171.1K	1.99M	41K	+31.51%
Mar 31, 2024	WELLINGTON MANAGEMENT GROUP LLP	0.38%	307.92K	3.58M	68.9K	+28.82%
Mar 31, 2024	CANDRIAM S.C.A.	0.38%	310K	3.61M	30K	+10.71%
Mar 31, 2024	UBS GROUP AG	0.4%	320.73K	3.73M	36.24K	+12.74%
Mar 31, 2024	BARCLAYS PLC	0.44%	354.09K	4.12M	-189.46K	-34.86%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.51%	408.64K	4.76M	136.74K	+50.29%
Mar 31, 2024	UNIVERSITY OF WISCONSIN FOUNDATION	0.62%	498.14K	5.8M	371.62K	+293.73%
Mar 31, 2024	SPHERA FUNDS MANAGEMENT LTD.	0.64%	515.88K	6M	107.21K	+26.23%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.68%	550.59K	6.41M	308.21K	+127.15%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.78%	629.23K	7.32M	129.88K	+26.01%
Mar 31, 2024	EAGLE ASSET MANAGEMENT INC	0.84%	679.77K	7.29M	-22.33K	-3.18%
Mar 31, 2024	NORTHERN TRUST CORP	0.89%	714.53K	8.32M	96.53K	+15.62%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.92%	744.95K	8.67M	113.84K	+18.04%
Mar 31, 2024	ORCHARD CAPITAL MANAGEMENT, LLC	0.93%	749.35K	8.72M	10.14K	+1.37%
Mar 31, 2024	MORGAN STANLEY	1.01%	812.62K	9.46M	-676.64K	-45.43%
Mar 31, 2024	FRANKLIN RESOURCES INC	1.03%	827.66K	9.63M	-46	-0.01%
Mar 31, 2024	SUPERSTRING CAPITAL MANAGEMENT LP	1.17%	941.29K	10.96M	-80.19K	-7.85%
Mar 31, 2024	BIOIMPACT CAPITAL LLC	1.2%	967.74K	11.26M	967.74K	+100.00%
Mar 31, 2024	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	1.24%	1M	11.64M	-1M	-50.00%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	1.35%	1.09M	12.65M	528.31K	+94.53%
Mar 31, 2024	HOLOCENE ADVISORS, LP	4.28%	3.45M	40.17M	-39.94K	-1.14%
Mar 31, 2024	PICTET ASSET MANAGEMENT HOLDING SA	4.6%	3.71M	43.19M	-847.49K	-18.59%
Mar 31, 2024	BVF INC/IL	5.02%	4.05M	47.11M	0	0
Mar 31, 2024	STATE STREET CORP	6.87%	5.54M	64.53M	144.23K	+2.67%
Mar 31, 2024	SUVRETTA CAPITAL MANAGEMENT, LLC	7.8%	6.3M	73.31M	1.41M	+28.83%
Mar 31, 2024	RTW INVESTMENTS, LP	9.14%	7.38M	85.89M	1.8M	+32.26%
Mar 31, 2024	JANUS HENDERSON GROUP PLC	15.62%	12.6M	146.65M	3.69M	+41.37%
Mar 31, 2024	RA CAPITAL MANAGEMENT, L.P.	15.82%	12.77M	148.61M	1.35M	+11.82%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.29%	231.01K	2.69M	-67.98K	-22.74%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.3%	246.1K	2.86M	117.34K	+91.13%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.31%	248.75K	2.9M	26.33K	+11.84%
Mar 31, 2024	NEWTYN MANAGEMENT, LLC	0.31%	250K	2.91M	-22.5K	-8.26%
Mar 31, 2024	INTEGRAL HEALTH ASSET MANAGEMENT, LLC	0.37%	300K	3.49M	300K	+100.00%
Mar 31, 2024	ALYESKA INVESTMENT GROUP, L.P.	0.37%	300K	3.49M	-283.19K	-48.56%
Mar 31, 2024	CITIGROUP INC	0.52%	418.26K	4.87M	203.66K	+94.90%
Mar 31, 2024	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.56%	450K	5.24M	-2.68M	-85.60%
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	0.57%	461.95K	5.38M	8.28K	+1.82%
Mar 31, 2024	ABRDN PLC	0.58%	470.39K	5.48M	256.2K	+119.61%
Mar 31, 2024	CAPTION MANAGEMENT, LLC	0.59%	474.9K	5.53M	0	0
Mar 31, 2024	CITADEL ADVISORS LLC	1.95%	1.57M	18.27M	-608.8K	-27.95%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	2.16%	1.74M	20.27M	363.16K	+26.36%
Mar 31, 2024	WESTFIELD CAPITAL MANAGEMENT CO LP	2.68%	2.16M	25.19M	403K	+22.88%
Mar 31, 2024	REDMILE GROUP, LLC	2.81%	2.26M	26.36M	295.16K	+14.99%
Mar 31, 2024	LAURION CAPITAL MANAGEMENT LP	3.35%	2.7M	31.42M	-4.73K	-0.17%
Mar 31, 2024	VANGUARD GROUP INC	5.85%	4.72M	54.98M	415.39K	+9.64%
Mar 31, 2024	BLACKROCK INC.	8.23%	6.64M	77.27M	1.18M	+21.70%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.03%	27.8K	323.57K	-5.59K	-16.75%
Mar 31, 2024	NEW YORK STATE COMMON RETIREMENT FUND	0.04%	28.98K	337K	2.94K	+11.27%
Mar 31, 2024	GILLILAND JETER WEALTH MANAGEMENT LLC	0.04%	32.93K	383.26K	13.93K	+73.29%
Mar 31, 2024	BOURGEON CAPITAL MANAGEMENT LLC	0.04%	33.65K	391.69K	-1.65K	-4.67%
Mar 31, 2024	INVESCO LTD.	0.04%	34.9K	406.26K	-66.32K	-65.52%
Mar 31, 2024	AMERICAN INTERNATIONAL GROUP, INC.	0.05%	38.97K	453.59K	7.14K	+22.43%
Mar 31, 2024	METLIFE INVESTMENT MANAGEMENT, LLC	0.05%	40.6K	472.55K	7.98K	+24.46%
Mar 31, 2024	JUMP FINANCIAL, LLC	0.06%	46.3K	538.97K	46.3K	+100.00%
Mar 31, 2024	TREXQUANT INVESTMENT LP	0.07%	54.27K	631.7K	54.27K	+100.00%
Mar 31, 2024	CREDIT SUISSE AG/	0.07%	60.1K	699.6K	3.27K	+5.75%
Mar 31, 2024	JPMORGAN CHASE & CO	0.08%	60.81K	707.86K	-138.12K	-69.43%
Mar 31, 2024	ALPS ADVISORS INC	0.08%	65.95K	767.62K	13.49K	+25.72%
Mar 31, 2024	PROFUND ADVISORS LLC	0.09%	71.74K	835.05M	-1.4K	-1.92%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.09%	76.47K	890.13M	2.9K	+3.95%
Mar 31, 2024	1492 CAPITAL MANAGEMENT LLC	0.1%	79.17K	921.52K	-50	-0.06%
Mar 31, 2024	JEFFERIES FINANCIAL GROUP INC.	0.1%	79.9K	930.05K	15.79K	+24.62%
Mar 31, 2024	DEKABANK DEUTSCHE GIROZENTRALE	0.11%	90K	1.02M	0	0
Mar 31, 2024	SILVERARC CAPITAL MANAGEMENT, LLC	0.11%	92.3K	1.07M	-66.42K	-41.85%
Mar 31, 2024	NATIXIS	0.12%	99K	1.15M	99K	+100.00%
Mar 31, 2024	WELLS FARGO & COMPANY/MN	0.13%	101.51K	1.18M	15.66K	+18.24%
Mar 31, 2024	RHUMBLINE ADVISERS	0.13%	101.61K	1.18M	17.52K	+20.84%
Mar 31, 2024	CAPSTONE INVESTMENT ADVISORS, LLC	0.13%	103.77K	1.21M	103.77K	+100.00%
Mar 31, 2024	RAYMOND JAMES FINANCIAL SERVICES ADVISORS, INC.	0.15%	117.31K	1.37M	13.02K	+12.48%
Mar 31, 2024	STATE OF WISCONSIN INVESTMENT BOARD	0.15%	118.76K	1.38M	-3.11K	-2.55%
Mar 31, 2024	RAYMOND JAMES & ASSOCIATES	0.17%	135.27K	1.57M	26.87K	+24.79%
Mar 31, 2024	SWISS NATIONAL BANK	0.18%	147.2K	1.71M	4.4K	+3.08%
Dec 31, 2023	NORTHERN TRUST CORP	0.81%	618K	6.9M	37.34K	+6.43%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.83%	631.11K	7.05M	112.44K	+21.68%
Dec 31, 2023	EAGLE ASSET MANAGEMENT INC	0.92%	702.1K	7.84M	-10.8K	-1.52%
Dec 31, 2023		0.53%	408.26K	4.56M	408.26K	+100.00%
Dec 31, 2023	ORCHARD CAPITAL MANAGEMENT, LLC	0.97%	739.21K	8.26M	196.33K	+36.16%
Dec 31, 2023	FRANKLIN RESOURCES INC	1.08%	827.7K	9.25M	320	+0.04%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.8%	1.38M	15.39M	83.72K	+6.47%
Dec 31, 2023	MORGAN STANLEY	1.95%	1.49M	16.64M	889.51K	+148.31%
Dec 31, 2023	WESTFIELD CAPITAL MANAGEMENT CO LP	2.31%	1.76M	19.67M	449.26K	+34.25%
Dec 31, 2023	FEDERATED HERMES, INC.	2.57%	1.96M	21.92M	-167.04K	-7.84%
Dec 31, 2023	REDMILE GROUP, LLC	2.58%	1.97M	22M	1.21M	+158.47%
Dec 31, 2023	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	2.62%	2M	22.34M	2M	+100.00%
Dec 31, 2023	CITADEL ADVISORS LLC	2.85%	2.18M	24.33M	674.33K	+44.84%
Dec 31, 2023	LAURION CAPITAL MANAGEMENT LP	3.54%	2.7M	30.21M	1.5M	+124.30%
Dec 31, 2023	ADAGE CAPITAL PARTNERS GP, L.L.C.	4.09%	3.13M	34.91M	1.43M	+83.99%
Dec 31, 2023	HOLOCENE ADVISORS, LP	4.57%	3.49M	38.99M	1.25M	+56.12%
Dec 31, 2023	BVF INC/IL	5.3%	4.05M	45.21M	2.2M	+119.23%
Dec 31, 2023	VANGUARD GROUP INC	5.64%	4.31M	48.12M	781.8K	+22.17%
Dec 31, 2023	SUVRETTA CAPITAL MANAGEMENT, LLC	6.4%	4.89M	54.6M	2.19M	+81.43%
Dec 31, 2023	STATE STREET CORP	7.07%	5.4M	60.31M	1.09M	+25.37%
Dec 31, 2023	BLACKROCK INC.	7.15%	5.45M	60.92M	487.96K	+9.83%
Dec 31, 2023	RTW INVESTMENTS, LP	7.31%	5.58M	62.32M	5.58M	+100.00%
Dec 31, 2023	JANUS HENDERSON GROUP PLC	11.68%	8.92M	99.57M	4.89M	+121.26%
Dec 31, 2023	RA CAPITAL MANAGEMENT, L.P.	14.96%	11.42M	127.53M	0	0
Dec 31, 2023	ABRDN PLC	0.28%	214.19K	2.39M	214.19K	+100.00%
Dec 31, 2023	CITIGROUP INC	0.28%	214.6K	2.4M	52.75K	+32.59%
Dec 31, 2023	PARKMAN HEALTHCARE PARTNERS LLC	0.29%	219.45K	2.45M	-144.11K	-39.64%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.29%	222.42K	2.48M	4.52K	+2.07%
Dec 31, 2023	WEISS MULTI-STRATEGY ADVISERS LLC	0.3%	230K	2.57M	163.67K	+246.75%
Dec 31, 2023	WELLINGTON MANAGEMENT GROUP LLP	0.31%	239.03K	2.67M	239.03K	+100.00%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.32%	242.39K	2.71M	-155.41K	-39.07%
Dec 31, 2023	ROYAL BANK OF CANADA	0.33%	248.93K	2.78M	23.43K	+10.39%
Dec 31, 2023	CAPTION MANAGEMENT, LLC	0.34%	260K	2.9M	144K	+124.14%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.36%	271.9K	3.04M	-163.5K	-37.55%
Dec 31, 2023	NEWTYN MANAGEMENT, LLC	0.36%	272.5K	3.04M	72K	+35.91%
Dec 31, 2023	CANDRIAM S.C.A.	0.37%	280K	3.13M	60K	+27.27%
Dec 31, 2023	UBS GROUP AG	0.37%	284.5K	3.18M	183.52K	+181.73%
Dec 31, 2023	ALLIANCEBERNSTEIN L.P.	0.39%	298.99K	3.34M	-44.69K	-13.00%
Dec 31, 2023	DEUTSCHE BANK AG\	0.5%	378.84K	4.23M	346.28K	+1,063.37%
Dec 31, 2023	QUBE RESEARCH & TECHNOLOGIES LTD	0.53%	403.32K	4.51M	403.32K	+100.00%
Dec 31, 2023	SPHERA FUNDS MANAGEMENT LTD.	0.54%	408.67K	4.56M	89.37K	+27.99%
Dec 31, 2023	RAFFERTY ASSET MANAGEMENT, LLC	0.59%	453.67K	5.07M	71.73K	+18.78%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.65%	499.35K	5.58M	10.35K	+2.12%
Dec 31, 2023	BARCLAYS PLC	0.71%	543.55K	6.07M	-80.81K	-12.94%
Dec 31, 2023	MARSHALL WACE, LLP	0.73%	554.34K	6.19M	-616.42K	-52.65%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	0.73%	558.89K	6.24M	453.03K	+427.98%
Dec 31, 2023	ALYESKA INVESTMENT GROUP, L.P.	0.76%	583.19K	6.51M	123.3K	+26.81%

Insiders

Among the ETNB insiders holding of 0.54% of the stake in company, RA CAPITAL MANAGEMENT, L.P., , holds the largest shares of 19.55M. SHAH RAJEEV M., , is the second largest ETNB insider with ownership of 7.78M shares. LONGITUDE CAPITAL PARTNERS III, LLC, 10 percent owner, stands third with possession of 2.6M shares of that stake.

Insiders	Designation	Shares Held
RA CAPITAL MANAGEMENT, L.P.		19.55M
SHAH RAJEEV M.		7.78M
LONGITUDE CAPITAL PARTNERS III, LLC	10 percent owner	2.6M
NASCHITZ ANAT		1.86M
ORBIMED ADVISORS LLC	10 percent owner	1.83M
PALEKAR ROHAN	Chief Executive Officer	471.24K
LE-NGUYEN QUOC	See Remarks	309.36K
KARIV TOMER		250K
HAYDEN MICHAEL R	director	61.54K
MARTINS RYAN	Chief Financial Officer	53.58K
MCWHERTER CHARLES	director	25K
GRUNBERG GREGORY	director	0
LAPORTE KATHLEEN	director	0
ATKINSON EDWARD MORROW III	director	0
WAISBOURD RAM	See Remarks	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Jul 15, 2025	LE-NGUYEN QUOC	SALE	11.02	10.46K	115.28K	309.36K
Apr 15, 2025	LE-NGUYEN QUOC	SALE	5.95	15.33K	91.21K	328.32K
Jan 30, 2025	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	8.75	5.71M	50M	19.55M
Jan 22, 2025	MCWHERTER CHARLES	PURCHASE	6.71	10K	67.1K	25K
Jan 21, 2025	MCWHERTER CHARLES	PURCHASE	6.55	5K	32.75K	15K
Jan 15, 2025	LE-NGUYEN QUOC	SALE	6.49	10.96K	71.15K	271.83K
Dec 06, 2024	PALEKAR ROHAN	PURCHASE	7.89	5K	39.45K	471.24K
Dec 05, 2024	MCWHERTER CHARLES	PURCHASE	8.00	10K	80K	10K
Nov 22, 2024	PALEKAR ROHAN	PURCHASE	8.35	10K	83.5K	466.24K
Nov 14, 2024	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	0.00	3.25M	3.25K	4.33M
Oct 30, 2024	LE-NGUYEN QUOC	SALE	8.12	27.96K	226.99K	187.8K
Apr 01, 2024	PALEKAR ROHAN	SALE	10.91	52.72K	575.15K	459.17K
Mar 04, 2024	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	15.35	1.35M	20.72M	12.43M
Feb 26, 2024	PALEKAR ROHAN	SALE	10.76	4.48K	48.17K	486.89K
Dec 29, 2023	PALEKAR ROHAN	SALE	11.20	50K	560K	301.23K
Dec 11, 2023	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	0.00	1.08M	1.08K	1.08M
Jul 17, 2023	LAPORTE KATHLEEN	SALE	18.80	12.5K	235K	0
Jun 05, 2023	PALEKAR ROHAN	SALE	20.00	15K	300K	286.98K
Jun 01, 2023	ATKINSON EDWARD MORROW III	SALE	17.91	6.25K	111.94K	0
May 09, 2023	LE-NGUYEN QUOC	SALE	18.11	13.68K	247.8K	164.97K
Apr 04, 2023	MARTINS RYAN	SALE	14.95	8.72K	130.38K	53.58K
Mar 28, 2023	HAYDEN MICHAEL R	PURCHASE	16.15	61.54K	993.84K	61.54K
Mar 24, 2023	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	16.25	2.46M	40M	11.08M
Mar 23, 2023	PALEKAR ROHAN	SALE	16.00	15K	240K	269.08K
Mar 23, 2023	MARTINS RYAN	SALE	16.11	5K	80.55K	53.58K
Mar 01, 2023	ATKINSON EDWARD MORROW III	SALE	13.60	10K	136K	0
Feb 21, 2023	MARTINS RYAN	SALE	13.89	2.54K	35.28K	58.58K
Feb 08, 2023	MARTINS RYAN	SALE	14.41	1.48K	21.33K	32.87K
Feb 03, 2023	MARTINS RYAN	SALE	12.70	592	7.52K	35.37K
Jan 03, 2023	MARTINS RYAN	SALE	12.51	5.95K	74.4K	36.37K
Oct 18, 2022	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	7.65	1.17M	8.97M	8.96M
Jul 01, 2022	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	5.33	2.82M	15M	1.41M
Jul 01, 2022	SHAH RAJEEV M.	PURCHASE	3.55	2.82M	10M	7.78M
Apr 25, 2022	HAYDEN MICHAEL R	PURCHASE	2.67	10K	26.7K	103.98K
Apr 07, 2022	HAYDEN MICHAEL R	PURCHASE	3.48	10K	34.75K	93.98K
Mar 30, 2022	HAYDEN MICHAEL R	PURCHASE	3.62	6.25K	22.63K	83.98K
Feb 01, 2022	WAISBOURD RAM	SALE	5.70	7K	39.9K	0
Jan 28, 2022	PALEKAR ROHAN	PURCHASE	6.14	2.5K	15.35K	45.85K
Jan 27, 2022	PALEKAR ROHAN	PURCHASE	7.50	5K	37.5K	43.35K
Jan 26, 2022	ORBIMED ADVISORS LLC	SALE	8.38	10.74K	90.02K	1.83M
Jan 25, 2022	ORBIMED ADVISORS LLC	SALE	8.40	24.55K	206.19K	1.84M
Dec 16, 2021	WAISBOURD RAM	SALE	11.48	7K	80.36K	0
Nov 16, 2021	WAISBOURD RAM	SALE	16.49	7K	115.43K	0
Oct 18, 2021	WAISBOURD RAM	SALE	17.49	7K	122.43K	0
Sep 16, 2021	WAISBOURD RAM	SALE	19.46	7K	136.22K	0
Aug 16, 2021	WAISBOURD RAM	SALE	18.28	7K	127.96K	0
Jul 16, 2021	WAISBOURD RAM	SALE	16.80	7K	117.6K	0
Jul 08, 2021	PALEKAR ROHAN	PURCHASE	16.25	2K	32.5K	37K
Jul 07, 2021	PALEKAR ROHAN	PURCHASE	17.07	5K	85.35K	35K
Jun 16, 2021	WAISBOURD RAM	SALE	19.67	7K	137.69K	0
Jun 02, 2021	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	18.77	22.14K	415.53K	4.97M
May 28, 2021	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	18.77	123.51K	2.32M	4.94M
May 27, 2021	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	18.76	35.54K	666.64K	4.82M
May 26, 2021	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	18.03	48.38K	872.24K	4.78M
May 17, 2021	WAISBOURD RAM	SALE	21.61	7K	151.27K	0
Apr 21, 2021	GRUNBERG GREGORY	SALE	27.60	850	23.46K	0
Apr 19, 2021	MARTINS RYAN	SALE	25.00	10K	250K	7.5K
Apr 16, 2021	WAISBOURD RAM	SALE	24.22	7K	169.54K	0
Mar 16, 2021	WAISBOURD RAM	SALE	24.20	7K	169.4K	0
Feb 16, 2021	WAISBOURD RAM	SALE	23.39	7K	163.73K	0
Jan 19, 2021	WAISBOURD RAM	SALE	21.16	7K	148.12K	0
Dec 16, 2020	WAISBOURD RAM	SALE	27.04	7K	189.28K	0
Nov 16, 2020	LE-NGUYEN QUOC	SALE	28.11	4.55K	127.84K	0
Nov 16, 2020	WAISBOURD RAM	SALE	27.39	7K	191.73K	0
Sep 21, 2020	NASCHITZ ANAT	SALE	28.00	137.5K	3.85M	1.86M
Sep 21, 2020	ORBIMED ADVISORS LLC	SALE	28.00	137.5K	3.85M	1.86M
Sep 17, 2020	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	28.00	1.3M	36.4M	4.74M
Jul 10, 2020	GRUNBERG GREGORY	PURCHASE	27.50	109.09K	3M	2.6M
Jul 10, 2020	LONGITUDE CAPITAL PARTNERS III, LLC	PURCHASE	27.50	109.09K	3M	2.6M
Jul 08, 2020	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	27.50	275K	7.56M	3.44M
Nov 11, 2019	HAYDEN MICHAEL R	PURCHASE	16.00	18.75K	300K	18.75K
Nov 11, 2019	GRUNBERG GREGORY	PURCHASE	16.00	575K	9.2M	575K
Nov 11, 2019	KARIV TOMER	PURCHASE	16.00	250K	4M	250K
Nov 11, 2019	ORBIMED ADVISORS LLC	PURCHASE	16.00	418.75K	6.7M	724.36K
Nov 11, 2019	LONGITUDE CAPITAL PARTNERS III, LLC	PURCHASE	16.00	575K	9.2M	575K
Nov 11, 2019	NASCHITZ ANAT	PURCHASE	16.00	418.75K	6.7M	724.36K
Nov 11, 2019	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	16.00	1.5M	24M	1.5M

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES10.46K1

NET SHARES-10.46K1

SHARES HELD309.36K1

% NET SHARES-103.38%0%

Frequently Asked Questions

Stock Outstanding Shares

ShortableNo

OptionableYes

Short Percent Of Outstanding Shares10.64

Short Percent Of Float14.73

Shares Outstanding148.31M

Shares Float103.73M

Shares Short15.79M

Short Ratio11.3

14.73%

Short % of Float

10.64%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

0.54% Percentage of Shares held by All Insiders

111.87% Percentage of Shares held by All Institutions

112.48% Percentage of Float held by Institutions

258

Number of Institutions Holding Shares

Institutional Ownership

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	SUPERSTRING CAPITAL MANAGEMENT LP	0.24%	384.65K	5.65M	172.28K	+81.12%
Sep 30, 2025	EVERSEPT PARTNERS, LP	0.25%	392.44K	5.77M	156.45K	+66.30%
Sep 30, 2025	GROUPE LA FRANCAISE	0.25%	400K	5.88M	400K	+100.00%
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	12.6%	19.89M	292.38M	0	0
Sep 30, 2025	ERSTE ASSET MANAGEMENT GMBH	0.53%	833K	12.25M	-50K	-5.66%
Sep 30, 2025	LMR PARTNERS LLP	0.63%	1M	14.7M	1M	+100.00%
Sep 30, 2025	NUVEEN, LLC	0.25%	400.15K	5.88M	-238.67K	-37.36%
Sep 30, 2025	RAYMOND JAMES FINANCIAL INC	0.26%	417.76K	6.14M	-153.85K	-26.91%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.46%	725.82K	10.67M	-236.65K	-24.59%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.52%	820.62K	12.06M	-429.33K	-34.35%
Sep 30, 2025	CSS LLC/IL	0.26%	409.57K	6.02M	409.57K	+100.00%
Sep 30, 2025	YAKIRA CAPITAL MANAGEMENT, INC.	0.16%	251.99K	3.7M	251.99K	+100.00%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.19%	293.94K	4.32M	144.92K	+97.25%
Sep 30, 2025	JBF CAPITAL, INC.	0.47%	735K	50K	735K	+100.00%
Sep 30, 2025	JANUS HENDERSON GROUP PLC	3.41%	5.38M	79.06M	-15.41M	-74.13%
Sep 30, 2025	GLAZER CAPITAL, LLC	3.57%	5.64M	82.86M	5.64M	+100.00%
Sep 30, 2025	AVORO CAPITAL ADVISORS LLC	4.05%	6.39M	93.9M	-362.21K	-5.37%
Sep 30, 2025	VANGUARD GROUP INC	5.1%	8.05M	118.39M	-188.7K	-2.29%
Sep 30, 2025	DEEP TRACK CAPITAL, LP	5.93%	9.36M	137.54M	-143.83K	-1.51%
Sep 30, 2025	EMERALD ADVISERS, LLC	0.34%	535.15K	7.87M	-1.31M	-70.98%
Sep 30, 2025	GABELLI & CO INVESTMENT ADVISERS, INC.	0.26%	417.85K	6.14M	417.85K	+100.00%
Sep 30, 2025	JANE STREET GROUP, LLC	0.27%	428.72K	6.3M	428.72K	+100.00%
Sep 30, 2025	GABELLI FUNDS LLC	0.27%	434.03K	6.38M	434.03K	+100.00%
Sep 30, 2025	MORGAN STANLEY	0.28%	444.77K	6.54M	-1.74M	-79.64%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.32%	510.5K	7.5M	-2.9K	-0.56%
Sep 30, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.32%	512.05K	7.53M	-633.76K	-55.31%
Sep 30, 2025	BARCLAYS PLC	0.33%	527.07K	7.75M	38.36K	+7.85%
Sep 30, 2025	ALPINE ASSOCIATES MANAGEMENT INC.	0.34%	529.8K	7.79M	529.8K	+100.00%
Sep 30, 2025	OMERS ADMINISTRATION CORP	0.36%	575.1K	8.45M	575.1K	+100.00%
Sep 30, 2025	CREDIT INDUSTRIEL ET COMMERCIAL	0.38%	600K	8.82M	600K	+100.00%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.64%	1M	14.75M	-60.9K	-5.72%
Sep 30, 2025	NORTHERN TRUST CORP	0.71%	1.13M	16.55M	-6.65K	-0.59%
Sep 30, 2025	NEWTYN MANAGEMENT, LLC	0.51%	800K	11.76M	600K	+300.00%
Sep 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	1.34%	2.11M	31.06M	1.24M	+141.23%
Sep 30, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	1.38%	2.17M	31.93M	1.95M	+862.34%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	1.02%	1.61M	23.62M	423.56K	+35.80%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.96%	3.09M	45.46M	-18.96K	-0.61%
Sep 30, 2025	DEUTSCHE BANK AG\	2.22%	3.5M	51.44M	3.41M	+3,941.65%
Sep 30, 2025	STATE STREET CORP	3.35%	5.29M	77.71M	1.04M	+24.39%
Sep 30, 2025	SUVRETTA CAPITAL MANAGEMENT, LLC	5.24%	8.28M	121.72M	-5.93M	-41.73%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	5.76%	9.1M	133.73M	7.13M	+362.04%
Sep 30, 2025	TIG ADVISORS, LLC	1.39%	2.19M	32.14M	2.19M	+100.00%
Sep 30, 2025	KRYGER CAPITAL LTD	1.49%	2.35M	34.55M	2.35M	+100.00%
Sep 30, 2025	SYQUANT CAPITAL SAS	1.64%	2.59M	38.13M	2.59M	+100.00%
Sep 30, 2025	WESTFIELD CAPITAL MANAGEMENT CO LP	2.08%	3.29M	48.38M	-79.45K	-2.36%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.41%	651.87K	9.58M	322.01K	+97.62%
Sep 30, 2025	UBS GROUP AG	0.42%	666.84K	9.8M	317.4K	+90.83%
Sep 30, 2025	REDMILE GROUP, LLC	0.93%	1.47M	21.66M	-72.07K	-4.66%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.02%	1.62M	23.77M	363.7K	+29.02%
Sep 30, 2025	GILLILAND JETER WEALTH MANAGEMENT LLC	0.04%	60.5K	889.34K	7.75K	+14.69%
Sep 30, 2025	MINT TOWER CAPITAL MANAGEMENT B.V.	0.04%	70K	1.03M	70K	+100.00%
Sep 30, 2025	JPMORGAN CHASE & CO	0.05%	71.18K	1.05M	-8.4K	-10.55%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.05%	74.66K	1.1M	0	0
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.05%	82.83K	1.22M	-22.34K	-21.24%
Sep 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.06%	90K	1.1M	0	0
Sep 30, 2025	PANAGORA ASSET MANAGEMENT INC	0.06%	90.25K	1.33M	-239.63K	-72.64%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.06%	90.5K	1.33M	15.12K	+20.06%
Sep 30, 2025	SIMPLEX TRADING, LLC	0.07%	108.25K	1.59M	99.05K	+1,077.47%
Sep 30, 2025	CITIGROUP INC	0.09%	144.44K	2.12M	-71.89K	-33.23%
Sep 30, 2025	QUINN OPPORTUNITY PARTNERS LLC	0.1%	150K	2.21M	150K	+100.00%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.69%	1.09M	16.09M	1.09M	+100.00%
Sep 30, 2025	WEISS ASSET MANAGEMENT LP	0.89%	1.4M	20.58M	1.4M	+100.00%
Sep 30, 2025	SANDERS MORRIS HARRIS LLC	0.1%	163.91K	2.41M	163.91K	+100.00%
Sep 30, 2025	INVESCO LTD.	0.1%	165.42K	2.43M	13.73K	+9.05%
Sep 30, 2025	RHUMBLINE ADVISERS	0.12%	189.82K	2.79M	-4K	-2.06%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.12%	189.84K	2.79M	67.48K	+55.16%
Sep 30, 2025	ORCHARD CAPITAL MANAGEMENT, LLC	0.13%	204.11K	3M	6K	+3.03%
Sep 30, 2025	SWISS NATIONAL BANK	0.13%	212.2K	3.12M	17K	+8.71%
Sep 30, 2025	ROYCE & ASSOCIATES LP	0.14%	226.06K	3.32M	0	0
Sep 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.15%	242.56K	3.57M	-11.7K	-4.60%
Sep 30, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.15%	242.72K	3.57M	-1.93M	-88.82%
Sep 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.16%	248.5K	3.65M	36.54K	+17.24%
Sep 30, 2025	BLACKROCK, INC.	6.53%	10.32M	151.65M	-253.03K	-2.39%
Sep 30, 2025	PENTWATER CAPITAL MANAGEMENT LP	7.44%	11.75M	172.73M	11.75M	+100.00%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.22%	349.68K	5.14M	107	+0.03%
Sep 30, 2025	VIVO CAPITAL, LLC	0.24%	376.8K	5.54M	0	0
Jun 30, 2025	ATOM INVESTORS LP	0.13%	205.95K	2.02M	112.78K	+121.05%
Jun 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.13%	211.96K	2.08M	71.65K	+51.07%
Jun 30, 2025	SPHERA FUNDS MANAGEMENT LTD.	0.13%	205.68K	2.02M	-412.67K	-66.74%
Jun 30, 2025	NEWTYN MANAGEMENT, LLC	0.13%	200K	1.96M	0	0
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.33%	513.4K	5.04M	9.1K	+1.80%
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	12.6%	19.89M	195.32M	0	0
Jun 30, 2025	SUVRETTA CAPITAL MANAGEMENT, LLC	9%	14.21M	139.54M	-125.24K	-0.87%
Jun 30, 2025	BLACKROCK, INC.	6.69%	10.57M	103.79M	494.08K	+4.90%
Jun 30, 2025	SUSQUEHANNA PORTFOLIO STRATEGIES, LLC	0.08%	126.51K	1.24M	102.41K	+424.93%
Jun 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.08%	122.35K	1.2M	-14.89K	-10.85%
Jun 30, 2025	ALGERT GLOBAL LLC	0.08%	121.98K	1.2M	-65.01K	-34.77%
Jun 30, 2025	VERITION FUND MANAGEMENT LLC	0.08%	121.16K	1.19M	121.16K	+100.00%
Jun 30, 2025	J. GOLDMAN & CO LP	0.06%	96.34K	946.05K	-46.23K	-32.42%
Jun 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.06%	90K	1.1M	0	0
Jun 30, 2025	WESTFIELD CAPITAL MANAGEMENT CO LP	2.13%	3.37M	33.1M	-523.92K	-13.45%
Jun 30, 2025	ORCHARD CAPITAL MANAGEMENT, LLC	0.13%	198.12K	1.95M	-266.24K	-57.33%
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	0.09%	149.02K	1.46M	-36.28K	-19.58%
Jun 30, 2025	STATE OF WISCONSIN INVESTMENT BOARD	0.09%	148K	1.45M	29.3K	+24.68%
Jun 30, 2025	DEEP TRACK CAPITAL, LP	6.02%	9.5M	93.29M	183.67K	+1.97%
Jun 30, 2025		0.32%	500K	4.91M	0	0
Jun 30, 2025	FMR LLC	0.36%	569.01K	5.59M	-121.01K	-17.54%
Jun 30, 2025	RAYMOND JAMES FINANCIAL INC	0.36%	571.6K	5.61M	189.31K	+49.52%
Jun 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.37%	576.97K	5.67M	-275.25K	-32.30%
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.39%	619.6K	6.08M	539.9K	+677.42%
Jun 30, 2025	INFINITUM ASSET MANAGEMENT, LLC	0.32%	500K	4.91M	0	0
Jun 30, 2025	NUVEEN, LLC	0.4%	638.83K	6.27M	-397.13K	-38.33%
Jun 30, 2025	CAPTION MANAGEMENT, LLC	0.42%	665.6K	6.54M	308.8K	+86.55%
Jun 30, 2025	ERSTE ASSET MANAGEMENT GMBH	0.56%	883K	8.68M	0	0
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.22%	349.57K	3.43M	39.66K	+12.80%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.23%	367.27K	3.61M	117.07K	+46.79%
Jun 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.25%	391.41K	3.84M	122.61K	+45.61%
Jun 30, 2025	BARCLAYS PLC	0.31%	488.71K	4.8M	-338.15K	-40.90%
Jun 30, 2025	WOODLINE PARTNERS LP	0.77%	1.22M	12.01M	521.91K	+74.48%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.79%	1.25M	12.27M	468K	+59.85%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.79%	1.25M	12.31M	257.64K	+25.88%
Jun 30, 2025	ASSENAGON ASSET MANAGEMENT S.A.	1.38%	2.17M	21.32M	1.74M	+406.23%
Jun 30, 2025	MORGAN STANLEY	1.38%	2.19M	21.46M	1.56M	+247.25%
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	1.44%	2.27M	22.33M	2.27M	+100.00%
Jun 30, 2025	POLAR CAPITAL HOLDINGS PLC	1.57%	2.48M	24.3M	-25K	-1.00%
Jun 30, 2025	UNIVERSITY OF WISCONSIN FOUNDATION	0.73%	1.15M	11.33M	0	0
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.75%	1.18M	11.62M	595.24K	+101.23%
Jun 30, 2025	VIVO CAPITAL, LLC	0.24%	376.8K	3.7M	0	0
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.24%	383.19K	3.76M	383.19K	+100.00%
Jun 30, 2025	CANDRIAM S.C.A.	0.49%	766.21K	7.52M	-65.61K	-7.89%
Jun 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.55%	875.98K	8.6M	71.76K	+8.92%
Jun 30, 2025	READYSTATE ASSET MANAGEMENT LP	0.57%	902.08K	8.86M	216.91K	+31.66%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.61%	962.47K	9.45M	510.02K	+112.72%
Jun 30, 2025	INTEGRAL HEALTH ASSET MANAGEMENT, LLC	0.67%	1.05M	10.31M	0	0
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.67%	1.06M	10.45M	78.2K	+7.93%
Jun 30, 2025	NORTHERN TRUST CORP	0.72%	1.13M	11.12M	46.97K	+4.33%
Jun 30, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.73%	1.15M	11.25M	62.84K	+5.80%
Jun 30, 2025	HOLOCENE ADVISORS, LP	1.94%	3.07M	30.1M	3.07M	+100.00%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.97%	3.11M	30.56M	213.33K	+7.36%
Jun 30, 2025	CITADEL ADVISORS LLC	2.43%	3.84M	37.68M	-1.25M	-24.57%
Jun 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	2.56%	4.04M	39.63M	-169.5K	-4.03%
Jun 30, 2025	STATE STREET CORP	2.69%	4.25M	41.73M	219.65K	+5.45%
Jun 30, 2025	AVORO CAPITAL ADVISORS LLC	4.28%	6.75M	66.29M	400K	+6.30%
Jun 30, 2025	VANGUARD GROUP INC	5.22%	8.24M	80.94M	1.08M	+15.06%
Jun 30, 2025	JANUS HENDERSON GROUP PLC	13.17%	20.79M	204.19M	325.46K	+1.59%
Jun 30, 2025	REDMILE GROUP, LLC	0.98%	1.55M	15.17M	-341.24K	-18.09%
Jun 30, 2025	EMERALD ADVISERS, LLC	1.17%	1.84M	18.11M	293.7K	+18.94%
Jun 30, 2025	RTW INVESTMENTS, LP	1.25%	1.97M	19.32M	0	0
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.25%	1.97M	19.34M	1.97M	+100.00%
Jun 30, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	1.29%	2.04M	20M	526.59K	+34.86%
Jun 30, 2025	APIS CAPITAL ADVISORS, LLC	0.2%	322K	3.16M	7K	+2.22%
Jun 30, 2025	TREXQUANT INVESTMENT LP	0.18%	281.03K	2.76M	181.84K	+183.34%
Jun 30, 2025	DARK FOREST CAPITAL MANAGEMENT LP	0.17%	266.4K	2.62M	205.97K	+340.90%
Jun 30, 2025	ROYAL BANK OF CANADA	0.17%	260.64K	2.56M	193.95K	+290.84%
Jun 30, 2025	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.16%	255.8K	2.51M	-10.67K	-4.00%
Jun 30, 2025	EVERSEPT PARTNERS, LP	0.15%	235.99K	2.32M	-67.74K	-22.30%
Jun 30, 2025	JENNISON ASSOCIATES LLC	0.15%	234.19K	2.3M	234.19K	+100.00%
Jun 30, 2025	EXOME ASSET MANAGEMENT LLC	0.15%	233.43K	2.29M	-120.46K	-34.04%
Jun 30, 2025	ROYCE & ASSOCIATES LP	0.14%	226.06K	2.22M	8	0.00%
Jun 30, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.14%	225.7K	2.22M	-24.5K	-9.79%
Jun 30, 2025	HARBOR CAPITAL ADVISORS, INC.	0.14%	217.75K	2.14M	-97.02K	-30.82%
Jun 30, 2025	F/M INVESTMENTS LLC	0.14%	217.74K	2.14M	2.91K	+1.35%
Jun 30, 2025	SUPERSTRING CAPITAL MANAGEMENT LP	0.13%	212.38K	2.09M	103.22K	+94.56%
Mar 31, 2025	READYSTATE ASSET MANAGEMENT LP	0.47%	685.17K	4.98M	685.17K	+100.00%
Mar 31, 2025	LOGOS GLOBAL MANAGEMENT LP	1.71%	2.5M	18.18M	2.5M	+100.00%
Mar 31, 2025	POLAR CAPITAL HOLDINGS PLC	1.71%	2.5M	18.18M	2.5M	+100.00%
Mar 31, 2025	RTW INVESTMENTS, LP	1.34%	1.97M	14.3M	-5.51M	-73.69%
Mar 31, 2025	REDMILE GROUP, LLC	1.29%	1.89M	13.71M	-280.73K	-12.95%
Mar 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.58%	852.23K	6.2M	-73.17K	-7.91%
Mar 31, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.58%	844.44K	6.14M	291.7K	+52.77%
Mar 31, 2025	BARCLAYS PLC	0.56%	826.86K	6.01M	186.89K	+29.20%
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.55%	804.22K	5.85M	289.08K	+56.12%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.53%	781.95K	5.68M	423.38K	+118.07%
Mar 31, 2025	MORGAN STANLEY	0.43%	629.23K	4.57M	287.28K	+84.01%
Mar 31, 2025	RAYMOND JAMES FINANCIAL INC	0.26%	382.29K	2.78M	4.92K	+1.30%
Mar 31, 2025	CAPTION MANAGEMENT, LLC	0.24%	356.8K	2.59M	-75.3K	-17.43%
Mar 31, 2025	BECK BODE, LLC	1.24%	1.82M	13.2M	1.82M	+100.00%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.34%	504.3K	3.67M	206.6K	+69.40%
Mar 31, 2025	ORCHARD CAPITAL MANAGEMENT, LLC	0.32%	464.36K	3.38M	421.73K	+989.40%
Mar 31, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.29%	428.9K	3.12M	186.29K	+76.79%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.31%	452.45K	3.29M	-255.74K	-36.11%
Mar 31, 2025	VIVO CAPITAL, LLC	0.26%	376.8K	2.74M	376.8K	+100.00%
Mar 31, 2025	SPHERA FUNDS MANAGEMENT LTD.	0.42%	618.34K	4.5M	61.81K	+11.11%
Mar 31, 2025	LORD, ABBETT & CO. LLC	0.5%	733.4K	5.33M	733.4K	+100.00%
Mar 31, 2025	WOODLINE PARTNERS LP	0.48%	700.75K	5.09M	305.93K	+77.48%
Mar 31, 2025	FMR LLC	0.47%	690.01K	5.02M	597.85K	+648.65%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.4%	587.99K	4.28M	245.76K	+71.81%
Mar 31, 2025	PANAGORA ASSET MANAGEMENT INC	0.29%	429.39K	3.12M	314K	+272.12%
Mar 31, 2025	DEEP TRACK CAPITAL, LP	6.37%	9.32M	67.73M	2.84M	+43.81%
Mar 31, 2025	SUVRETTA CAPITAL MANAGEMENT, LLC	9.79%	14.34M	104.22M	4.13M	+40.50%
Mar 31, 2025	BLACKROCK, INC.	6.88%	10.08M	73.25M	2.19M	+27.70%
Mar 31, 2025	VANGUARD GROUP INC	4.89%	7.16M	52.08M	1.47M	+25.85%
Mar 31, 2025	AVORO CAPITAL ADVISORS LLC	4.34%	6.35M	46.16M	2.25M	+54.88%
Mar 31, 2025	CITADEL ADVISORS LLC	3.48%	5.09M	36.98M	356.98K	+7.55%
Mar 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	2.87%	4.2M	30.57M	1.2M	+39.84%
Mar 31, 2025	STATE STREET CORP	2.75%	4.03M	29.3M	1.09M	+36.84%
Mar 31, 2025	WESTFIELD CAPITAL MANAGEMENT CO LP	2.66%	3.89M	28.31M	7.95K	+0.20%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.98%	2.9M	21.07M	690.37K	+31.27%
Mar 31, 2025	EMERALD ADVISERS, LLC	1.06%	1.55M	11.27M	1.55M	+100.00%
Mar 31, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	1.03%	1.51M	10.98M	1.41M	+1,465.10%
Mar 31, 2025	NORTHERN TRUST CORP	0.74%	1.09M	7.89M	230.68K	+26.99%
Mar 31, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.74%	1.08M	7.87M	1.08M	+100.00%
Mar 31, 2025	INTEGRAL HEALTH ASSET MANAGEMENT, LLC	0.72%	1.05M	7.63M	50K	+5.00%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.68%	995.45K	7.24M	188.37K	+23.34%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.67%	985.77K	7.17M	174.95K	+21.58%
Mar 31, 2025	CANDRIAM S.C.A.	0.57%	831.82K	6.05M	-223.84K	-21.20%
Mar 31, 2025	UNIVERSITY OF WISCONSIN FOUNDATION	0.79%	1.15M	8.38M	236K	+25.73%
Mar 31, 2025	SIO CAPITAL MANAGEMENT, LLC	0.34%	500K	3.64M	500K	+100.00%
Mar 31, 2025		0.34%	500K	3.64M	500K	+100.00%
Mar 31, 2025	JANUS HENDERSON GROUP PLC	13.98%	20.46M	165.29M	3.95M	+23.91%
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	13.59%	19.89M	144.6M	5.71M	+40.31%
Mar 31, 2024	PARKMAN HEALTHCARE PARTNERS LLC	0.22%	179.9K	2.09M	-39.55K	-18.02%
Mar 31, 2024	COMERICA BANK	0.21%	171K	1.99M	15.07K	+9.66%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.21%	171.1K	1.99M	41K	+31.51%
Mar 31, 2024	WELLINGTON MANAGEMENT GROUP LLP	0.38%	307.92K	3.58M	68.9K	+28.82%
Mar 31, 2024	CANDRIAM S.C.A.	0.38%	310K	3.61M	30K	+10.71%
Mar 31, 2024	UBS GROUP AG	0.4%	320.73K	3.73M	36.24K	+12.74%
Mar 31, 2024	BARCLAYS PLC	0.44%	354.09K	4.12M	-189.46K	-34.86%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.51%	408.64K	4.76M	136.74K	+50.29%
Mar 31, 2024	UNIVERSITY OF WISCONSIN FOUNDATION	0.62%	498.14K	5.8M	371.62K	+293.73%
Mar 31, 2024	SPHERA FUNDS MANAGEMENT LTD.	0.64%	515.88K	6M	107.21K	+26.23%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.68%	550.59K	6.41M	308.21K	+127.15%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.78%	629.23K	7.32M	129.88K	+26.01%
Mar 31, 2024	EAGLE ASSET MANAGEMENT INC	0.84%	679.77K	7.29M	-22.33K	-3.18%
Mar 31, 2024	NORTHERN TRUST CORP	0.89%	714.53K	8.32M	96.53K	+15.62%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.92%	744.95K	8.67M	113.84K	+18.04%
Mar 31, 2024	ORCHARD CAPITAL MANAGEMENT, LLC	0.93%	749.35K	8.72M	10.14K	+1.37%
Mar 31, 2024	MORGAN STANLEY	1.01%	812.62K	9.46M	-676.64K	-45.43%
Mar 31, 2024	FRANKLIN RESOURCES INC	1.03%	827.66K	9.63M	-46	-0.01%
Mar 31, 2024	SUPERSTRING CAPITAL MANAGEMENT LP	1.17%	941.29K	10.96M	-80.19K	-7.85%
Mar 31, 2024	BIOIMPACT CAPITAL LLC	1.2%	967.74K	11.26M	967.74K	+100.00%
Mar 31, 2024	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	1.24%	1M	11.64M	-1M	-50.00%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	1.35%	1.09M	12.65M	528.31K	+94.53%
Mar 31, 2024	HOLOCENE ADVISORS, LP	4.28%	3.45M	40.17M	-39.94K	-1.14%
Mar 31, 2024	PICTET ASSET MANAGEMENT HOLDING SA	4.6%	3.71M	43.19M	-847.49K	-18.59%
Mar 31, 2024	BVF INC/IL	5.02%	4.05M	47.11M	0	0
Mar 31, 2024	STATE STREET CORP	6.87%	5.54M	64.53M	144.23K	+2.67%
Mar 31, 2024	SUVRETTA CAPITAL MANAGEMENT, LLC	7.8%	6.3M	73.31M	1.41M	+28.83%
Mar 31, 2024	RTW INVESTMENTS, LP	9.14%	7.38M	85.89M	1.8M	+32.26%
Mar 31, 2024	JANUS HENDERSON GROUP PLC	15.62%	12.6M	146.65M	3.69M	+41.37%
Mar 31, 2024	RA CAPITAL MANAGEMENT, L.P.	15.82%	12.77M	148.61M	1.35M	+11.82%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.29%	231.01K	2.69M	-67.98K	-22.74%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.3%	246.1K	2.86M	117.34K	+91.13%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.31%	248.75K	2.9M	26.33K	+11.84%
Mar 31, 2024	NEWTYN MANAGEMENT, LLC	0.31%	250K	2.91M	-22.5K	-8.26%
Mar 31, 2024	INTEGRAL HEALTH ASSET MANAGEMENT, LLC	0.37%	300K	3.49M	300K	+100.00%
Mar 31, 2024	ALYESKA INVESTMENT GROUP, L.P.	0.37%	300K	3.49M	-283.19K	-48.56%
Mar 31, 2024	CITIGROUP INC	0.52%	418.26K	4.87M	203.66K	+94.90%
Mar 31, 2024	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.56%	450K	5.24M	-2.68M	-85.60%
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	0.57%	461.95K	5.38M	8.28K	+1.82%
Mar 31, 2024	ABRDN PLC	0.58%	470.39K	5.48M	256.2K	+119.61%
Mar 31, 2024	CAPTION MANAGEMENT, LLC	0.59%	474.9K	5.53M	0	0
Mar 31, 2024	CITADEL ADVISORS LLC	1.95%	1.57M	18.27M	-608.8K	-27.95%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	2.16%	1.74M	20.27M	363.16K	+26.36%
Mar 31, 2024	WESTFIELD CAPITAL MANAGEMENT CO LP	2.68%	2.16M	25.19M	403K	+22.88%
Mar 31, 2024	REDMILE GROUP, LLC	2.81%	2.26M	26.36M	295.16K	+14.99%
Mar 31, 2024	LAURION CAPITAL MANAGEMENT LP	3.35%	2.7M	31.42M	-4.73K	-0.17%
Mar 31, 2024	VANGUARD GROUP INC	5.85%	4.72M	54.98M	415.39K	+9.64%
Mar 31, 2024	BLACKROCK INC.	8.23%	6.64M	77.27M	1.18M	+21.70%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.03%	27.8K	323.57K	-5.59K	-16.75%
Mar 31, 2024	NEW YORK STATE COMMON RETIREMENT FUND	0.04%	28.98K	337K	2.94K	+11.27%
Mar 31, 2024	GILLILAND JETER WEALTH MANAGEMENT LLC	0.04%	32.93K	383.26K	13.93K	+73.29%
Mar 31, 2024	BOURGEON CAPITAL MANAGEMENT LLC	0.04%	33.65K	391.69K	-1.65K	-4.67%
Mar 31, 2024	INVESCO LTD.	0.04%	34.9K	406.26K	-66.32K	-65.52%
Mar 31, 2024	AMERICAN INTERNATIONAL GROUP, INC.	0.05%	38.97K	453.59K	7.14K	+22.43%
Mar 31, 2024	METLIFE INVESTMENT MANAGEMENT, LLC	0.05%	40.6K	472.55K	7.98K	+24.46%
Mar 31, 2024	JUMP FINANCIAL, LLC	0.06%	46.3K	538.97K	46.3K	+100.00%
Mar 31, 2024	TREXQUANT INVESTMENT LP	0.07%	54.27K	631.7K	54.27K	+100.00%
Mar 31, 2024	CREDIT SUISSE AG/	0.07%	60.1K	699.6K	3.27K	+5.75%
Mar 31, 2024	JPMORGAN CHASE & CO	0.08%	60.81K	707.86K	-138.12K	-69.43%
Mar 31, 2024	ALPS ADVISORS INC	0.08%	65.95K	767.62K	13.49K	+25.72%
Mar 31, 2024	PROFUND ADVISORS LLC	0.09%	71.74K	835.05M	-1.4K	-1.92%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.09%	76.47K	890.13M	2.9K	+3.95%
Mar 31, 2024	1492 CAPITAL MANAGEMENT LLC	0.1%	79.17K	921.52K	-50	-0.06%
Mar 31, 2024	JEFFERIES FINANCIAL GROUP INC.	0.1%	79.9K	930.05K	15.79K	+24.62%
Mar 31, 2024	DEKABANK DEUTSCHE GIROZENTRALE	0.11%	90K	1.02M	0	0
Mar 31, 2024	SILVERARC CAPITAL MANAGEMENT, LLC	0.11%	92.3K	1.07M	-66.42K	-41.85%
Mar 31, 2024	NATIXIS	0.12%	99K	1.15M	99K	+100.00%
Mar 31, 2024	WELLS FARGO & COMPANY/MN	0.13%	101.51K	1.18M	15.66K	+18.24%
Mar 31, 2024	RHUMBLINE ADVISERS	0.13%	101.61K	1.18M	17.52K	+20.84%
Mar 31, 2024	CAPSTONE INVESTMENT ADVISORS, LLC	0.13%	103.77K	1.21M	103.77K	+100.00%
Mar 31, 2024	RAYMOND JAMES FINANCIAL SERVICES ADVISORS, INC.	0.15%	117.31K	1.37M	13.02K	+12.48%
Mar 31, 2024	STATE OF WISCONSIN INVESTMENT BOARD	0.15%	118.76K	1.38M	-3.11K	-2.55%
Mar 31, 2024	RAYMOND JAMES & ASSOCIATES	0.17%	135.27K	1.57M	26.87K	+24.79%
Mar 31, 2024	SWISS NATIONAL BANK	0.18%	147.2K	1.71M	4.4K	+3.08%
Dec 31, 2023	NORTHERN TRUST CORP	0.81%	618K	6.9M	37.34K	+6.43%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.83%	631.11K	7.05M	112.44K	+21.68%
Dec 31, 2023	EAGLE ASSET MANAGEMENT INC	0.92%	702.1K	7.84M	-10.8K	-1.52%
Dec 31, 2023		0.53%	408.26K	4.56M	408.26K	+100.00%
Dec 31, 2023	ORCHARD CAPITAL MANAGEMENT, LLC	0.97%	739.21K	8.26M	196.33K	+36.16%
Dec 31, 2023	FRANKLIN RESOURCES INC	1.08%	827.7K	9.25M	320	+0.04%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.8%	1.38M	15.39M	83.72K	+6.47%
Dec 31, 2023	MORGAN STANLEY	1.95%	1.49M	16.64M	889.51K	+148.31%
Dec 31, 2023	WESTFIELD CAPITAL MANAGEMENT CO LP	2.31%	1.76M	19.67M	449.26K	+34.25%
Dec 31, 2023	FEDERATED HERMES, INC.	2.57%	1.96M	21.92M	-167.04K	-7.84%
Dec 31, 2023	REDMILE GROUP, LLC	2.58%	1.97M	22M	1.21M	+158.47%
Dec 31, 2023	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	2.62%	2M	22.34M	2M	+100.00%
Dec 31, 2023	CITADEL ADVISORS LLC	2.85%	2.18M	24.33M	674.33K	+44.84%
Dec 31, 2023	LAURION CAPITAL MANAGEMENT LP	3.54%	2.7M	30.21M	1.5M	+124.30%
Dec 31, 2023	ADAGE CAPITAL PARTNERS GP, L.L.C.	4.09%	3.13M	34.91M	1.43M	+83.99%
Dec 31, 2023	HOLOCENE ADVISORS, LP	4.57%	3.49M	38.99M	1.25M	+56.12%
Dec 31, 2023	BVF INC/IL	5.3%	4.05M	45.21M	2.2M	+119.23%
Dec 31, 2023	VANGUARD GROUP INC	5.64%	4.31M	48.12M	781.8K	+22.17%
Dec 31, 2023	SUVRETTA CAPITAL MANAGEMENT, LLC	6.4%	4.89M	54.6M	2.19M	+81.43%
Dec 31, 2023	STATE STREET CORP	7.07%	5.4M	60.31M	1.09M	+25.37%
Dec 31, 2023	BLACKROCK INC.	7.15%	5.45M	60.92M	487.96K	+9.83%
Dec 31, 2023	RTW INVESTMENTS, LP	7.31%	5.58M	62.32M	5.58M	+100.00%
Dec 31, 2023	JANUS HENDERSON GROUP PLC	11.68%	8.92M	99.57M	4.89M	+121.26%
Dec 31, 2023	RA CAPITAL MANAGEMENT, L.P.	14.96%	11.42M	127.53M	0	0
Dec 31, 2023	ABRDN PLC	0.28%	214.19K	2.39M	214.19K	+100.00%
Dec 31, 2023	CITIGROUP INC	0.28%	214.6K	2.4M	52.75K	+32.59%
Dec 31, 2023	PARKMAN HEALTHCARE PARTNERS LLC	0.29%	219.45K	2.45M	-144.11K	-39.64%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.29%	222.42K	2.48M	4.52K	+2.07%
Dec 31, 2023	WEISS MULTI-STRATEGY ADVISERS LLC	0.3%	230K	2.57M	163.67K	+246.75%
Dec 31, 2023	WELLINGTON MANAGEMENT GROUP LLP	0.31%	239.03K	2.67M	239.03K	+100.00%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.32%	242.39K	2.71M	-155.41K	-39.07%
Dec 31, 2023	ROYAL BANK OF CANADA	0.33%	248.93K	2.78M	23.43K	+10.39%
Dec 31, 2023	CAPTION MANAGEMENT, LLC	0.34%	260K	2.9M	144K	+124.14%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.36%	271.9K	3.04M	-163.5K	-37.55%
Dec 31, 2023	NEWTYN MANAGEMENT, LLC	0.36%	272.5K	3.04M	72K	+35.91%
Dec 31, 2023	CANDRIAM S.C.A.	0.37%	280K	3.13M	60K	+27.27%
Dec 31, 2023	UBS GROUP AG	0.37%	284.5K	3.18M	183.52K	+181.73%
Dec 31, 2023	ALLIANCEBERNSTEIN L.P.	0.39%	298.99K	3.34M	-44.69K	-13.00%
Dec 31, 2023	DEUTSCHE BANK AG\	0.5%	378.84K	4.23M	346.28K	+1,063.37%
Dec 31, 2023	QUBE RESEARCH & TECHNOLOGIES LTD	0.53%	403.32K	4.51M	403.32K	+100.00%
Dec 31, 2023	SPHERA FUNDS MANAGEMENT LTD.	0.54%	408.67K	4.56M	89.37K	+27.99%
Dec 31, 2023	RAFFERTY ASSET MANAGEMENT, LLC	0.59%	453.67K	5.07M	71.73K	+18.78%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.65%	499.35K	5.58M	10.35K	+2.12%
Dec 31, 2023	BARCLAYS PLC	0.71%	543.55K	6.07M	-80.81K	-12.94%
Dec 31, 2023	MARSHALL WACE, LLP	0.73%	554.34K	6.19M	-616.42K	-52.65%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	0.73%	558.89K	6.24M	453.03K	+427.98%
Dec 31, 2023	ALYESKA INVESTMENT GROUP, L.P.	0.76%	583.19K	6.51M	123.3K	+26.81%

Insiders

Insiders	Designation	Shares Held
RA CAPITAL MANAGEMENT, L.P.		19.55M
SHAH RAJEEV M.		7.78M
LONGITUDE CAPITAL PARTNERS III, LLC	10 percent owner	2.6M
NASCHITZ ANAT		1.86M
ORBIMED ADVISORS LLC	10 percent owner	1.83M
PALEKAR ROHAN	Chief Executive Officer	471.24K
LE-NGUYEN QUOC	See Remarks	309.36K
KARIV TOMER		250K
HAYDEN MICHAEL R	director	61.54K
MARTINS RYAN	Chief Financial Officer	53.58K
MCWHERTER CHARLES	director	25K
GRUNBERG GREGORY	director	0
LAPORTE KATHLEEN	director	0
ATKINSON EDWARD MORROW III	director	0
WAISBOURD RAM	See Remarks	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Jul 15, 2025	LE-NGUYEN QUOC	SALE	11.02	10.46K	115.28K	309.36K
Apr 15, 2025	LE-NGUYEN QUOC	SALE	5.95	15.33K	91.21K	328.32K
Jan 30, 2025	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	8.75	5.71M	50M	19.55M
Jan 22, 2025	MCWHERTER CHARLES	PURCHASE	6.71	10K	67.1K	25K
Jan 21, 2025	MCWHERTER CHARLES	PURCHASE	6.55	5K	32.75K	15K
Jan 15, 2025	LE-NGUYEN QUOC	SALE	6.49	10.96K	71.15K	271.83K
Dec 06, 2024	PALEKAR ROHAN	PURCHASE	7.89	5K	39.45K	471.24K
Dec 05, 2024	MCWHERTER CHARLES	PURCHASE	8.00	10K	80K	10K
Nov 22, 2024	PALEKAR ROHAN	PURCHASE	8.35	10K	83.5K	466.24K
Nov 14, 2024	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	0.00	3.25M	3.25K	4.33M
Oct 30, 2024	LE-NGUYEN QUOC	SALE	8.12	27.96K	226.99K	187.8K
Apr 01, 2024	PALEKAR ROHAN	SALE	10.91	52.72K	575.15K	459.17K
Mar 04, 2024	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	15.35	1.35M	20.72M	12.43M
Feb 26, 2024	PALEKAR ROHAN	SALE	10.76	4.48K	48.17K	486.89K
Dec 29, 2023	PALEKAR ROHAN	SALE	11.20	50K	560K	301.23K
Dec 11, 2023	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	0.00	1.08M	1.08K	1.08M
Jul 17, 2023	LAPORTE KATHLEEN	SALE	18.80	12.5K	235K	0
Jun 05, 2023	PALEKAR ROHAN	SALE	20.00	15K	300K	286.98K
Jun 01, 2023	ATKINSON EDWARD MORROW III	SALE	17.91	6.25K	111.94K	0
May 09, 2023	LE-NGUYEN QUOC	SALE	18.11	13.68K	247.8K	164.97K
Apr 04, 2023	MARTINS RYAN	SALE	14.95	8.72K	130.38K	53.58K
Mar 28, 2023	HAYDEN MICHAEL R	PURCHASE	16.15	61.54K	993.84K	61.54K
Mar 24, 2023	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	16.25	2.46M	40M	11.08M
Mar 23, 2023	PALEKAR ROHAN	SALE	16.00	15K	240K	269.08K
Mar 23, 2023	MARTINS RYAN	SALE	16.11	5K	80.55K	53.58K
Mar 01, 2023	ATKINSON EDWARD MORROW III	SALE	13.60	10K	136K	0
Feb 21, 2023	MARTINS RYAN	SALE	13.89	2.54K	35.28K	58.58K
Feb 08, 2023	MARTINS RYAN	SALE	14.41	1.48K	21.33K	32.87K
Feb 03, 2023	MARTINS RYAN	SALE	12.70	592	7.52K	35.37K
Jan 03, 2023	MARTINS RYAN	SALE	12.51	5.95K	74.4K	36.37K
Oct 18, 2022	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	7.65	1.17M	8.97M	8.96M
Jul 01, 2022	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	5.33	2.82M	15M	1.41M
Jul 01, 2022	SHAH RAJEEV M.	PURCHASE	3.55	2.82M	10M	7.78M
Apr 25, 2022	HAYDEN MICHAEL R	PURCHASE	2.67	10K	26.7K	103.98K
Apr 07, 2022	HAYDEN MICHAEL R	PURCHASE	3.48	10K	34.75K	93.98K
Mar 30, 2022	HAYDEN MICHAEL R	PURCHASE	3.62	6.25K	22.63K	83.98K
Feb 01, 2022	WAISBOURD RAM	SALE	5.70	7K	39.9K	0
Jan 28, 2022	PALEKAR ROHAN	PURCHASE	6.14	2.5K	15.35K	45.85K
Jan 27, 2022	PALEKAR ROHAN	PURCHASE	7.50	5K	37.5K	43.35K
Jan 26, 2022	ORBIMED ADVISORS LLC	SALE	8.38	10.74K	90.02K	1.83M
Jan 25, 2022	ORBIMED ADVISORS LLC	SALE	8.40	24.55K	206.19K	1.84M
Dec 16, 2021	WAISBOURD RAM	SALE	11.48	7K	80.36K	0
Nov 16, 2021	WAISBOURD RAM	SALE	16.49	7K	115.43K	0
Oct 18, 2021	WAISBOURD RAM	SALE	17.49	7K	122.43K	0
Sep 16, 2021	WAISBOURD RAM	SALE	19.46	7K	136.22K	0
Aug 16, 2021	WAISBOURD RAM	SALE	18.28	7K	127.96K	0
Jul 16, 2021	WAISBOURD RAM	SALE	16.80	7K	117.6K	0
Jul 08, 2021	PALEKAR ROHAN	PURCHASE	16.25	2K	32.5K	37K
Jul 07, 2021	PALEKAR ROHAN	PURCHASE	17.07	5K	85.35K	35K
Jun 16, 2021	WAISBOURD RAM	SALE	19.67	7K	137.69K	0
Jun 02, 2021	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	18.77	22.14K	415.53K	4.97M
May 28, 2021	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	18.77	123.51K	2.32M	4.94M
May 27, 2021	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	18.76	35.54K	666.64K	4.82M
May 26, 2021	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	18.03	48.38K	872.24K	4.78M
May 17, 2021	WAISBOURD RAM	SALE	21.61	7K	151.27K	0
Apr 21, 2021	GRUNBERG GREGORY	SALE	27.60	850	23.46K	0
Apr 19, 2021	MARTINS RYAN	SALE	25.00	10K	250K	7.5K
Apr 16, 2021	WAISBOURD RAM	SALE	24.22	7K	169.54K	0
Mar 16, 2021	WAISBOURD RAM	SALE	24.20	7K	169.4K	0
Feb 16, 2021	WAISBOURD RAM	SALE	23.39	7K	163.73K	0
Jan 19, 2021	WAISBOURD RAM	SALE	21.16	7K	148.12K	0
Dec 16, 2020	WAISBOURD RAM	SALE	27.04	7K	189.28K	0
Nov 16, 2020	LE-NGUYEN QUOC	SALE	28.11	4.55K	127.84K	0
Nov 16, 2020	WAISBOURD RAM	SALE	27.39	7K	191.73K	0
Sep 21, 2020	NASCHITZ ANAT	SALE	28.00	137.5K	3.85M	1.86M
Sep 21, 2020	ORBIMED ADVISORS LLC	SALE	28.00	137.5K	3.85M	1.86M
Sep 17, 2020	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	28.00	1.3M	36.4M	4.74M
Jul 10, 2020	GRUNBERG GREGORY	PURCHASE	27.50	109.09K	3M	2.6M
Jul 10, 2020	LONGITUDE CAPITAL PARTNERS III, LLC	PURCHASE	27.50	109.09K	3M	2.6M
Jul 08, 2020	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	27.50	275K	7.56M	3.44M
Nov 11, 2019	HAYDEN MICHAEL R	PURCHASE	16.00	18.75K	300K	18.75K
Nov 11, 2019	GRUNBERG GREGORY	PURCHASE	16.00	575K	9.2M	575K
Nov 11, 2019	KARIV TOMER	PURCHASE	16.00	250K	4M	250K
Nov 11, 2019	ORBIMED ADVISORS LLC	PURCHASE	16.00	418.75K	6.7M	724.36K
Nov 11, 2019	LONGITUDE CAPITAL PARTNERS III, LLC	PURCHASE	16.00	575K	9.2M	575K
Nov 11, 2019	NASCHITZ ANAT	PURCHASE	16.00	418.75K	6.7M	724.36K
Nov 11, 2019	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	16.00	1.5M	24M	1.5M

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES10.46K1

NET SHARES-10.46K1

SHARES HELD309.36K1

% NET SHARES-103.38%0%

ETNB Stock Ownership Breakdown

89bio

Stock Outstanding Shares

Market Insider

Institutional Ownership

Insiders

Buying/Selling by Insiders

Insider Transaction Summary (6 Months)

Frequently Asked Questions

Stock Outstanding Shares

Market Insider

Institutional Ownership

Insiders

Buying/Selling by Insiders

Insider Transaction Summary (6 Months)

Frequently Asked Questions