How many institutions own COGT stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own COGT shares is 243, representing 105.49% of the company's common stock.

Who are the major shareholders selling Cogent Biosciences, Inc. stock?

COMMODORE CAPITAL LP, in the last quarter, reduced its stake in COGT by -69.7% restricting it's holding to 2.2 million shares of worth nearly $78.03M. SIREN, L.L.C. also lessened -5.51% of the COGT shares from its portfolio, reducing its holding to 1.63 million shares of worth $57.87M. SOFINNOVA INVESTMENTS, INC. also shunned COGT shares holding by -7.25% last quarter which brought its holding to 1.97 million shares worth $70.10M.

Investors who are buying COGT stock?

As per its latest 13F filing, EMERALD ADVISERS, LLC increased its stake in COGT by 0.24% in the last quarter. The institutional holder raised its holding to 1.58 million shares having worth more than $56.24M. GOLDMAN SACHS GROUP INC also added 2.74% more shares of COGT to its portfolio, raising its holding to 1.71 million shares of worth $60.57M. DUQUESNE FAMILY OFFICE LLC also increased its COGT shares holding by 109% which brought its holding to 2.21 million shares worth $78.66M.

COGT's major insiders: who are they?

The insider with the most stakes in COGT is FROST PHILLIP MD ET AL , at the company. Additionally, COGT stock is highly held by Chief Executive Officer Schulke Ryan and director Fairmount Funds Management LLC among others.

Did an insider recently sell COGT stock?

Company executives, directors, and other insiders own 0.04% percent of Cogent Biosciences, Inc.'s stock. Within the last six months, there have been 5 transaction(s) in which COGT insiders have sold stock, totaling 3.81M shares. Insiders that have sold shares include FAIRMOUNT FUNDS MANAGEMENT LLC, KEARNS EVAN, and SACHS JESSICA.

Which insider recently purchased COGT stock?

There have been 0 transaction(s) during the past 6-months in which Cogent Biosciences, Inc. insiders have bought stock, totalling 0 shares

How much of COGT does insiders own?

Around 6.02M Cogent Biosciences, Inc. shares are held by insiders, which represents about 0.04% of COGT stock.

Who is the insider with the largest stake?

COGT , FROST PHILLIP MD ET AL holds the largest portfolio of the company's shares. COGT shares owned by FROST total nearly 15.73 million.

Which institution holds the most shares in COGT?

EMERALD ADVISERS, LLC is the largest institutional owner in COGT which holds 1.58 million shares worth $56.24M or 1.38% of the total COGT shares outstanding followed by GOLDMAN SACHS GROUP INC with ownership of 1.71 million shares representing 2.52% of the COGT ownership. COMMODORE CAPITAL LP is the third largest stakeholder with 2.2 million shares or 3.25% of the ownership worth more than $78.03M.

Is Cogent Biosciences, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the COGT is concerned, it is a stock which is optionable.

Is there a short position on COGT's shares?

Number of COGT shares short is 13.07M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding COGT shares are there?

As of today, 139.70M shares of COGT are outstanding.

Is there many float in COGT stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, COGT has 102.75M shares in float.

COGT short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for COGT is 10.

Cogent Biosciences (COGT) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares9.35

Short Percent Of Float10.62

Shares Outstanding139.70M

Shares Float102.75M

Shares Short13.07M

Short Ratio10

10.62%

Short % of Float

9.35%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

0.04% Percentage of Shares held by All Insiders

105.49% Percentage of Shares held by All Institutions

105.53% Percentage of Float held by Institutions

243

Number of Institutions Holding Shares

Institutional Ownership

About 105.49% of COGT shares are held by financial institutions. EMERALD ADVISERS, LLC is the top corporate investor, holding 1.58M shares valued at $56.24M. A 1.38% stake in Cogent Biosciences, Inc. is owned by the company. GOLDMAN SACHS GROUP INC owns 1.71M shares valued at $60.57M, which translates its holding of 2.52% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	EMERALD ADVISERS, LLC	1.38%	1.58M	56.24M	3.85K	+0.24%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	2.52%	1.71M	60.57M	45.47K	+2.74%
Dec 31, 2025	COMMODORE CAPITAL LP	3.25%	2.2M	78.03M	-5.05M	-69.70%
Dec 31, 2025	DUQUESNE FAMILY OFFICE LLC	3.28%	2.21M	78.66M	1.15M	+109.00%
Dec 31, 2025		0.84%	568.62K	20.2B	568.62K	+100.00%
Dec 31, 2025	RENAISSANCE TECHNOLOGIES LLC	1.02%	689.07K	24.48M	456.1K	+195.78%
Dec 31, 2025	AMERICAN CENTURY COMPANIES INC	1.32%	892.92K	31.72M	892.92K	+100.00%
Dec 31, 2025	SIREN, L.L.C.	1.42%	1.63M	57.87M	-95K	-5.51%
Dec 31, 2025	LORD, ABBETT & CO. LLC	1.63%	1.87M	66.44M	1.87M	+100.00%
Dec 31, 2025	SOFINNOVA INVESTMENTS, INC.	1.72%	1.97M	70.1M	-154.32K	-7.25%
Dec 31, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	1.09%	1.25M	44.23M	430.18K	+52.78%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	1.76%	1.19M	42.34M	-1.05M	-46.77%
Dec 31, 2025	JANE STREET GROUP, LLC	0.2%	135.3K	4.81B	121.6K	+887.59%
Dec 31, 2025	F/M INVESTMENTS LLC	0.21%	235.8K	8.38M	15.64K	+7.10%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.23%	153.63K	5.46M	72.62K	+89.65%
Dec 31, 2025	PATIENT SQUARE CAPITAL LP	0.28%	317.37K	11.27M	317.37K	+100.00%
Dec 31, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.3%	338.07K	12.01M	37.94K	+12.64%
Dec 31, 2025	RAYMOND JAMES FINANCIAL INC	0.33%	375.92K	13.35M	86.52K	+29.90%
Dec 31, 2025	ENSIGN PEAK ADVISORS, INC	0.37%	421.54K	14.97M	395.92K	+1,545.03%
Dec 31, 2025	FEDERATED HERMES, INC.	0.37%	426.78K	15.16M	333.56K	+357.80%
Dec 31, 2025	UBS GROUP AG	0.39%	264.05K	9.38M	-1.59M	-85.76%
Dec 31, 2025	DEEP TRACK CAPITAL, LP	0.4%	453.1K	16.09M	453.1K	+100.00%
Dec 31, 2025	EXOME ASSET MANAGEMENT LLC	0.45%	305.57K	10.85M	-137.98K	-31.11%
Dec 31, 2025	MACQUARIE MANAGEMENT HOLDINGS, INC.	0.45%	305.94K	10.87B	305.94K	+100.00%
Dec 31, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.52%	352.39K	12.52M	-231.5K	-39.65%
Dec 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.73%	493.93K	17.54M	393.93K	+393.93%
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	1.79%	1.21M	42.92M	793.26K	+191.16%
Dec 31, 2025	CANDRIAM S.C.A.	1.92%	1.3M	46.05M	342.27K	+35.87%
Dec 31, 2025	CITADEL ADVISORS LLC	2.13%	1.44M	51.11M	-228.81K	-13.72%
Dec 31, 2025	MARSHALL WACE, LLP	2.46%	1.66M	58.99M	1.02M	+158.49%
Dec 31, 2025	VIVO CAPITAL, LLC	3.55%	2.4M	85.21M	-390.14K	-13.99%
Dec 31, 2025	PLATINUM INVESTMENT MANAGEMENT LTD	0.11%	121.23K	4.31M	-98.28K	-44.77%
Dec 31, 2025	SQUAREPOINT OPS LLC	0.14%	155.98K	5.54M	155.98K	+100.00%
Dec 31, 2025	TUDOR INVESTMENT CORP ET AL	0.14%	159.94K	5.68M	159.94K	+100.00%
Dec 31, 2025	SEI INVESTMENTS CO	0.16%	179.41K	6.37M	168.09K	+1,484.37%
Dec 31, 2025	RHUMBLINE ADVISERS	0.27%	180.18K	6.4B	3.46K	+1.96%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.29%	198.97K	7.07M	-499K	-71.49%
Dec 31, 2025	BOXER CAPITAL MANAGEMENT, LLC	0.2%	225K	7.99M	225K	+100.00%
Dec 31, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	0.22%	250K	8.88M	-1.26M	-83.41%
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.31%	211.6K	7.52M	12.5K	+6.28%
Dec 31, 2025	AFFINITY ASSET ADVISORS, LLC	0.31%	350K	12.43M	350K	+100.00%
Dec 31, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.33%	375.63K	13.34M	-201.38K	-34.90%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.33%	376.3K	13.37M	13.28K	+3.66%
Dec 31, 2025	JPMORGAN CHASE & CO	0.35%	400.93K	14.24M	326.12K	+435.92%
Dec 31, 2025	MORGAN STANLEY	1.08%	726.78K	25.82M	-561.39K	-43.58%
Dec 31, 2025	FIRST TURN MANAGEMENT, LLC	0.72%	824.28K	29.28M	824.28K	+100.00%
Dec 31, 2025	NUVEEN, LLC	1.38%	932.62K	33.13M	-7K	-0.74%
Dec 31, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.91%	1.04M	36.89M	15.64K	+1.53%
Dec 31, 2025	OCTAGON CAPITAL ADVISORS LP	3.48%	2.35M	83.47M	-524.11K	-18.24%
Dec 31, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.74%	849.03K	30.16M	-159.28K	-15.80%
Dec 31, 2025	ATIKA CAPITAL MANAGEMENT LLC	0.75%	506K	17.97M	506K	+100.00%
Dec 31, 2025	INVESCO LTD.	0.87%	585.77K	20.81M	213.5K	+57.35%
Dec 31, 2025	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.99%	668.97K	23.76M	668.97K	+100.00%
Dec 31, 2025	NORTHERN TRUST CORP	1.05%	1.2M	42.6M	17.64K	+1.49%
Dec 31, 2025	SATURN V CAPITAL MANAGEMENT LLC	1.06%	1.22M	43.23M	-807.98K	-39.90%
Dec 31, 2025	WOODLINE PARTNERS LP	1.21%	818.78K	29.08M	305.39K	+59.48%
Dec 31, 2025	REDMILE GROUP, LLC	1.26%	1.44M	51.07M	-771.2K	-34.91%
Dec 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	1.26%	1.44M	51.16M	-1.23M	-46.07%
Dec 31, 2025	FRED ALGER MANAGEMENT, LLC	1.63%	1.1M	39.15M	1.1M	+100.00%
Dec 31, 2025	HOLOCENE ADVISORS, LP	1.74%	1.18M	41.85M	1.06M	+899.19%
Dec 31, 2025	VR ADVISER, LLC	1.75%	2M	71.04M	-2M	-50.00%
Dec 31, 2025	D. E. SHAW & CO., INC.	1.96%	2.25M	79.84M	716.88K	+46.83%
Dec 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	2.37%	2.71M	96.34M	2.31M	+566.59%
Dec 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	3.79%	2.56M	91.08M	2.47M	+2,757.98%
Dec 31, 2025	JANUS HENDERSON GROUP PLC	3.96%	4.54M	161.11M	1.36M	+42.77%
Dec 31, 2025	TCG CROSSOVER MANAGEMENT, LLC	5.13%	5.87M	208.44M	-930K	-13.68%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	5.2%	3.51M	124.86M	240.41K	+7.34%
Dec 31, 2025	KYNAM CAPITAL MANAGEMENT, LP	5.39%	6.17M	218.99M	-1.72M	-21.82%
Dec 31, 2025	FAIRMOUNT FUNDS MANAGEMENT LLC	7.87%	9M	319.8M	0	0
Dec 31, 2025	RTW INVESTMENTS, LP	11.23%	7.59M	269.68M	4.12M	+118.96%
Dec 31, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	13.38%	9.04M	321.24M	-9.22K	-0.10%
Dec 31, 2025	FMR LLC	20.17%	23.09M	820.05M	678.7K	+3.03%
Dec 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.14%	164.14K	5.83M	21.19K	+14.82%
Dec 31, 2025	SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)	0.14%	164.44K	5.84M	164.44K	+100.00%
Dec 31, 2025	SWISS NATIONAL BANK	0.14%	165.4K	5.88M	3.2K	+1.97%
Dec 31, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.15%	175.89K	6.25M	175.89K	+100.00%
Dec 31, 2025	PRUDENTIAL FINANCIAL INC	0.18%	120.18K	4.27B	104.78K	+680.61%
Dec 31, 2025	STATE STREET CORP	7.31%	4.94M	175.48M	164.88K	+3.45%
Dec 31, 2025	VANGUARD GROUP INC	17.03%	11.51M	408.99M	3.76M	+48.43%
Dec 31, 2025	BLACKROCK, INC.	19.19%	12.97M	460.86M	2.61M	+25.12%
Dec 31, 2025	DEUTSCHE BANK AG\	0.1%	109.13K	3.88M	13K	+13.52%
Dec 31, 2025	PRINCIPAL FINANCIAL GROUP INC	0.1%	111.81K	3.97M	-160.65K	-58.96%
Dec 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.1%	112.48K	4.23M	98.6K	+710.70%
Dec 31, 2025	WALLEYE CAPITAL LLC	0.1%	114.46K	4.07M	114.46K	+100.00%
Dec 31, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.1%	120K	4.26M	120K	+100.00%
Dec 31, 2025	LPL FINANCIAL LLC	0.11%	124.24K	4.41M	74.04K	+147.48%
Dec 31, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.12%	133.21K	4.73M	71.59K	+116.18%
Dec 31, 2025	EAM INVESTORS, LLC	0.12%	134.3K	4.77M	134.3K	+100.00%
Dec 31, 2025	NICHOLAS INVESTMENT PARTNERS, LP	0.13%	151.07K	5.37M	151.07K	+100.00%
Dec 31, 2025	BARCLAYS PLC	0.48%	321.61K	11.42M	-38.22K	-10.62%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	1.12%	1.28M	45.49M	90.13K	+7.57%
Sep 30, 2025	PLATINUM INVESTMENT MANAGEMENT LTD	0.19%	219.5K	3.15M	0	0
Sep 30, 2025	EMERALD ADVISERS, LLC	1.38%	1.58M	22.68M	133.72K	+9.25%
Sep 30, 2025	DUQUESNE FAMILY OFFICE LLC	0.93%	1.06M	15.22M	1.06M	+100.00%
Sep 30, 2025	TREXQUANT INVESTMENT LP	0.49%	566.37K	8.13M	65.33K	+13.04%
Sep 30, 2025	BLACKROCK, INC.	9.06%	10.37M	148.91M	1.74M	+20.20%
Sep 30, 2025	SIREN, L.L.C.	1.51%	1.72M	24.76M	869.9K	+101.82%
Sep 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	7.91%	9.05M	130M	6.41M	+242.89%
Sep 30, 2025	FAIRMOUNT FUNDS MANAGEMENT LLC	7.87%	9M	129.29M	2.78M	+44.62%
Sep 30, 2025	COMMODORE CAPITAL LP	6.33%	7.25M	104.11M	4.94M	+213.69%
Sep 30, 2025	STATE STREET CORP	4.17%	4.78M	68.58M	1.4M	+41.62%
Sep 30, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.89%	1.02M	14.69M	127.45K	+14.23%
Sep 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.88%	1.01M	14.48M	208.11K	+26.01%
Sep 30, 2025	CANDRIAM S.C.A.	0.83%	954.21K	13.7M	526.87K	+123.29%
Sep 30, 2025	BOONE CAPITAL MANAGEMENT LLC	0.83%	945.04K	13.57M	945.04K	+100.00%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.61%	697.96K	10.02M	482.55K	+224.01%
Sep 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.26%	300.13K	4.31M	-5.49K	-1.80%
Sep 30, 2025	PRINCIPAL FINANCIAL GROUP INC	0.24%	272.46K	3.91M	272.46K	+100.00%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.2%	232.97K	3.35M	232.97K	+100.00%
Sep 30, 2025	F/M INVESTMENTS LLC	0.19%	220.17K	3.16M	100.16K	+83.46%
Sep 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.16%	179.73K	2.54M	55.01K	+44.10%
Sep 30, 2025	RHUMBLINE ADVISERS	0.15%	176.71K	2.54M	20.2K	+12.90%
Sep 30, 2025	SWISS NATIONAL BANK	0.14%	162.2K	2.33M	23.1K	+16.61%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.13%	148.8K	2.14M	57.14K	+62.34%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.11%	120.95K	1.74M	27.73K	+29.74%
Sep 30, 2025	FISHER ASSET MANAGEMENT, LLC	0.09%	103.49K	1.49M	-7.42K	-6.69%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.09%	98.81K	1.42M	18.77K	+23.45%
Sep 30, 2025	DEUTSCHE BANK AG\	0.08%	96.13K	1.38M	38.4K	+66.51%
Sep 30, 2025	FEDERATED HERMES, INC.	0.08%	93.23K	1.34M	93.22K	+4,661,150.00%
Sep 30, 2025	NEOS INVESTMENT MANAGEMENT LLC	0.08%	89.92K	1.29M	-27.72K	-23.56%
Sep 30, 2025	TEMA ETFS LLC	0.08%	89.92K	1.29M	-27.72K	-23.56%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.07%	81K	1.16M	25.07K	+44.82%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.07%	75.7K	1.09M	11.99K	+18.82%
Sep 30, 2025	JPMORGAN CHASE & CO	0.07%	74.81K	1.07M	5.53K	+7.99%
Sep 30, 2025	SIMPLEX TRADING, LLC	0.06%	66.99K	961K	-12.37K	-15.59%
Sep 30, 2025	CAMPBELL & CO INVESTMENT ADVISER LLC	0.05%	61.63K	885.06K	61.63K	+100.00%
Sep 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.05%	61.62K	884.91K	32.28K	+110.00%
Sep 30, 2025	GROUP ONE TRADING, L.P.	0.04%	50.51K	725.25M	-21.94K	-30.28%
Sep 30, 2025	LPL FINANCIAL LLC	0.04%	50.2K	720.9K	31.2K	+164.18%
Sep 30, 2025	READYSTATE ASSET MANAGEMENT LP	0.04%	49.69K	713.58K	49.69K	+100.00%
Sep 30, 2025	PANAGORA ASSET MANAGEMENT INC	0.04%	44.04K	632.44K	44.04K	+100.00%
Sep 30, 2025	STRS OHIO	0.04%	41.5K	595.94K	35.5K	+591.67%
Sep 30, 2025	QUADRATURE CAPITAL LTD	0.04%	40.48K	580.82K	40.48K	+100.00%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	38.28K	549.69K	-17.14K	-30.93%
Sep 30, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.03%	35.68K	512.37K	12.11K	+51.37%
Sep 30, 2025	NUVEEN, LLC	0.82%	939.62K	13.49M	709.51K	+308.33%
Sep 30, 2025	OCTAGON CAPITAL ADVISORS LP	2.51%	2.87M	41.27M	111.11K	+4.02%
Sep 30, 2025	VIVO CAPITAL, LLC	2.44%	2.79M	40.05M	1.67M	+148.48%
Sep 30, 2025	REDMILE GROUP, LLC	1.93%	2.21M	31.72M	761.08K	+52.56%
Sep 30, 2025	SOFINNOVA INVESTMENTS, INC.	1.86%	2.13M	30.56M	-227.56K	-9.66%
Sep 30, 2025	SATURN V CAPITAL MANAGEMENT LLC	1.77%	2.03M	29.08M	-272.48K	-11.86%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.45%	1.66M	23.83M	459.24K	+38.26%
Sep 30, 2025	MORGAN STANLEY	1.13%	1.29M	18.5M	59.04K	+4.80%
Sep 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	1.08%	1.24M	17.78M	-3.67M	-74.80%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	1.04%	1.19M	17.1M	303.66K	+34.23%
Sep 30, 2025	NORTHERN TRUST CORP	1.03%	1.18M	16.97M	247.17K	+26.45%
Sep 30, 2025	UBS GROUP AG	1.62%	1.85M	26.62M	-1.66M	-47.32%
Sep 30, 2025	WOODLINE PARTNERS LP	0.45%	513.4K	7.37M	-487.21K	-48.69%
Sep 30, 2025	LOGOS GLOBAL MANAGEMENT LP	0.44%	500K	7.18M	500K	+100.00%
Sep 30, 2025	HIGHVISTA STRATEGIES LLC	0.4%	462.41K	6.64M	179.22K	+63.29%
Sep 30, 2025	EXOME ASSET MANAGEMENT LLC	0.39%	443.55K	6.37M	-90.1K	-16.88%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.36%	414.97K	5.96M	-555.01K	-57.22%
Sep 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	5.94%	6.8M	97.62M	-166.21K	-2.39%
Sep 30, 2025	JANUS HENDERSON GROUP PLC	2.78%	3.18M	45.6M	304.99K	+10.62%
Sep 30, 2025	D. E. SHAW & CO., INC.	1.34%	1.53M	21.98M	1.26M	+459.68%
Sep 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	1.32%	1.51M	21.64M	-148.7K	-8.98%
Sep 30, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.71%	815.08K	11.7M	815.08K	+100.00%
Sep 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.51%	583.89K	8.38M	63.76K	+12.26%
Sep 30, 2025	FMR LLC	19.58%	22.41M	321.78M	5.33M	+31.21%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.36%	406.9K	5.84M	109.54K	+36.84%
Sep 30, 2025	MACQUARIE GROUP LTD	0.35%	398.83K	5.73M	168.83K	+73.40%
Sep 30, 2025	CAPTION MANAGEMENT, LLC	0.33%	380K	5.46M	-928.6K	-70.96%
Sep 30, 2025	INVESCO LTD.	0.33%	372.27K	5.35M	259.21K	+229.27%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.32%	363.02K	5.21M	71.23K	+24.41%
Sep 30, 2025	SUPERSTRING CAPITAL MANAGEMENT LP	0.32%	361.41K	5.19M	-601.54K	-62.47%
Sep 30, 2025	BARCLAYS PLC	0.31%	359.83K	5.17M	39.27K	+12.25%
Sep 30, 2025	KYNAM CAPITAL MANAGEMENT, LP	6.89%	7.89M	113.25M	-606.39K	-7.14%
Sep 30, 2025	VANGUARD GROUP INC	6.78%	7.76M	111.4M	1.23M	+18.93%
Sep 30, 2025	VR ADVISER, LLC	3.49%	4M	57.44M	-755.41K	-15.89%
Sep 30, 2025	MARSHALL WACE, LLP	0.56%	642.48K	9.23M	642.48K	+100.00%
Sep 30, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.5%	577K	8.29M	380.35K	+193.40%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.49%	562K	8.07M	562K	+100.00%
Sep 30, 2025	RTW INVESTMENTS, LP	3.03%	3.47M	49.79M	3.47M	+100.00%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.86%	3.27M	47.03M	602.04K	+22.53%
Sep 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	2.76%	3.16M	45.33M	-7.2M	-69.51%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	2.33%	2.67M	38.35M	2.67M	+100.00%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	1.96%	2.24M	32.16M	838.29K	+59.84%
Sep 30, 2025	CITADEL ADVISORS LLC	1.46%	1.67M	23.95M	1.05M	+168.47%
Jun 30, 2025	TREXQUANT INVESTMENT LP	0.44%	501.04K	3.6M	317.22K	+172.57%
Jun 30, 2025	BLACKROCK, INC.	7.54%	8.63M	61.94M	451.05K	+5.52%
Jun 30, 2025	KYNAM CAPITAL MANAGEMENT, LP	7.42%	8.49M	60.98M	-612.44K	-6.73%
Jun 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	6.08%	6.96M	50M	0	0
Jun 30, 2025	FAIRMOUNT FUNDS MANAGEMENT LLC	5.44%	6.23M	44.7M	0	0
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	4.29%	4.91M	35.27M	-383.62K	-7.24%
Jun 30, 2025	VR ADVISER, LLC	4.15%	4.76M	34.14M	-929K	-16.34%
Jun 30, 2025	VESTAL POINT CAPITAL, LP	2.69%	3.08M	22.11M	80K	+2.67%
Jun 30, 2025	F/M INVESTMENTS LLC	0.1%	120.01K	861.68K	120.01K	+100.00%
Jun 30, 2025	NEOS INVESTMENT MANAGEMENT LLC	0.1%	117.64K	844.65K	46.08K	+64.39%
Jun 30, 2025	Y-INTERCEPT (HONG KONG) LTD	0.1%	116.13K	833.79K	72.63K	+166.96%
Jun 30, 2025	FISHER ASSET MANAGEMENT, LLC	0.1%	110.91K	796.32K	0	0
Jun 30, 2025	BOLLARD GROUP LLC	0.09%	105.06K	754K	105.06K	+100.00%
Jun 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	9.04%	10.35M	74.33M	1.39M	+15.49%
Jun 30, 2025	OCTAGON CAPITAL ADVISORS LP	2.41%	2.76M	19.84M	0	0
Jun 30, 2025	COMMODORE CAPITAL LP	2.02%	2.31M	16.59M	-6.58M	-74.01%
Jun 30, 2025	SATURN V CAPITAL MANAGEMENT LLC	2.01%	2.3M	16.5M	817.5K	+55.24%
Jun 30, 2025	PRELUDE CAPITAL MANAGEMENT, LLC	0.14%	163.18K	1.17M	-6.27K	-3.70%
Jun 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.11%	124.73K	895.55K	124.73K	+100.00%
Jun 30, 2025	VANGUARD GROUP INC	5.7%	6.52M	46.83M	464.61K	+7.67%
Jun 30, 2025	UBS GROUP AG	3.07%	3.52M	25.26M	414.54K	+13.35%
Jun 30, 2025	STATE STREET CORP	2.95%	3.37M	24.21M	-744.88K	-18.09%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.77%	886.99K	6.37M	60.69K	+7.35%
Jun 30, 2025	ALGERT GLOBAL LLC	0.75%	864.07K	6.2M	335.8K	+63.57%
Jun 30, 2025	SIREN, L.L.C.	0.75%	854.38K	6.13M	854.38K	+100.00%
Jun 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.7%	800.2K	5.75M	800.2K	+100.00%
Jun 30, 2025	CITADEL ADVISORS LLC	0.54%	621.24K	4.46M	131.55K	+26.86%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.5%	569.37K	4.09M	-7.83K	-1.36%
Jun 30, 2025	XTX TOPCO LTD	0.1%	116.49K	836.39K	95.42K	+452.81%
Jun 30, 2025	FMR LLC	14.92%	17.08M	122.62M	1.14K	+0.01%
Jun 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	2.31%	2.64M	18.96M	6.35K	+0.24%
Jun 30, 2025	MORGAN STANLEY	1.07%	1.23M	8.83M	-46.57K	-3.65%
Jun 30, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.15%	176.28K	1.27M	176.28K	+100.00%
Jun 30, 2025	CANDRIAM S.C.A.	0.37%	427.34K	3.07M	427.34K	+100.00%
Jun 30, 2025	CAPTION MANAGEMENT, LLC	0.38%	437.23K	3.14M	437.23K	+100.00%
Jun 30, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	1.52%	1.73M	12.45M	798.03K	+85.21%
Jun 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	1.45%	1.66M	11.89M	812.2K	+96.29%
Jun 30, 2025	ROYAL BANK OF CANADA	0.17%	189.71K	1.36B	184.38K	+3,462.59%
Jun 30, 2025	IKARIAN CAPITAL, LLC	0.9%	1.04M	7.44M	1.04M	+100.00%
Jun 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.27%	305.62K	2.19M	3.13K	+1.04%
Jun 30, 2025	HIGHVISTA STRATEGIES LLC	0.25%	283.19K	2.03M	3.51K	+1.26%
Jun 30, 2025	D. E. SHAW & CO., INC.	0.24%	273.54K	1.96B	56K	+25.75%
Jun 30, 2025	NEW LEAF VENTURE PARTNERS, L.L.C.	0.22%	250.77K	1.8M	0	0
Jun 30, 2025	PLATINUM INVESTMENT MANAGEMENT LTD	0.19%	219.5K	1.58M	85.59K	+63.92%
Jun 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.19%	215.41K	1.55B	209.23K	+3,381.72%
Jun 30, 2025	STATE OF WISCONSIN INVESTMENT BOARD	0.18%	201.99K	1.45M	37.78K	+23.00%
Jun 30, 2025	SPHERA FUNDS MANAGEMENT LTD.	0.17%	200K	1.44M	200K	+100.00%
Jun 30, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.17%	196.66K	1.41M	-277.03K	-58.48%
Jun 30, 2025		0.34%	392.21K	2.82M	0	0
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.35%	406.12K	2.92M	269.38K	+197.00%
Jun 30, 2025	JANUS HENDERSON GROUP PLC	2.51%	2.87M	20.64M	2.84M	+9,782.20%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.33%	2.67M	19.19M	256.26K	+10.61%
Jun 30, 2025	REDMILE GROUP, LLC	1.27%	1.45M	10.4M	-1.77M	-54.97%
Jun 30, 2025	EMERALD ADVISERS, LLC	1.26%	1.45M	10.38M	1.45M	+100.00%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	1.22%	1.4M	10.06M	329.71K	+30.78%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	1.05%	1.2M	8.62M	211.48K	+21.38%
Jun 30, 2025	VIVO CAPITAL, LLC	0.98%	1.12M	8.06M	0	0
Jun 30, 2025	WOODLINE PARTNERS LP	0.87%	1M	7.18M	-686.93K	-40.71%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.85%	969.97K	6.96M	455.48K	+88.53%
Jun 30, 2025	DIADEMA PARTNERS LP	0.34%	392.21K	2.82M	0	0
Jun 30, 2025	SUPERSTRING CAPITAL MANAGEMENT LP	0.84%	962.95K	6.91M	188.23K	+24.30%
Jun 30, 2025	NORTHERN TRUST CORP	0.82%	934.5K	6.71M	54.66K	+6.21%
Jun 30, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.78%	895.41K	6.43M	895.41K	+100.00%
Jun 30, 2025	SOFINNOVA INVESTMENTS, INC.	0.58%	660K	4.74M	660K	+100.00%
Jun 30, 2025	EXOME ASSET MANAGEMENT LLC	0.47%	533.65K	3.83M	-88.03K	-14.16%
Jun 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.45%	520.13K	3.73M	38.89K	+8.08%
Jun 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.44%	502K	3.6M	502K	+100.00%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.22%	254.77K	1.53M	11.84K	+4.87%
Mar 31, 2025	VR ADVISER, LLC	5.02%	5.68M	34.05M	0	0
Mar 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	4.67%	5.3M	31.72M	-51.76K	-0.97%
Mar 31, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.42%	473.69K	2.84M	0	0
Mar 31, 2025	READYSTATE ASSET MANAGEMENT LP	0.31%	350.18K	2.1M	-169.82K	-32.66%
Mar 31, 2025	SPHERA FUNDS MANAGEMENT LTD.	0.3%	335.02K	2.01M	335.02K	+100.00%
Mar 31, 2025	HIGHVISTA STRATEGIES LLC	0.25%	279.67K	1.68M	0	0
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.23%	258.3K	1.55M	-26.55K	-9.32%
Mar 31, 2025	FRANKLIN RESOURCES INC	1.17%	1.33M	7.95M	42.76K	+3.33%
Mar 31, 2025	MORGAN STANLEY	1.13%	1.28M	7.64M	317.07K	+33.07%
Mar 31, 2025	VIVO CAPITAL, LLC	0.99%	1.12M	6.72M	0	0
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.95%	1.07M	6.42M	1.03M	+2,642.10%
Mar 31, 2025	KYNAM CAPITAL MANAGEMENT, LP	8.04%	9.11M	54.54M	0	0
Mar 31, 2025	PARADIGM BIOCAPITAL ADVISORS LP	7.91%	8.96M	53.69M	4.05M	+82.28%
Mar 31, 2025	COMMODORE CAPITAL LP	7.85%	8.89M	53.27M	2.01M	+29.23%
Mar 31, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	0.74%	843.49K	5.05M	-9.37K	-1.10%
Mar 31, 2025	EXOME ASSET MANAGEMENT LLC	0.55%	621.68K	3.72M	621.68K	+100.00%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.51%	577.2K	3.46M	-166.45K	-22.38%
Mar 31, 2025	WALLEYE CAPITAL LLC	0.47%	533.88K	3.2M	-402.91K	-43.01%
Mar 31, 2025	ALGERT GLOBAL LLC	0.47%	528.26K	3.16M	184.03K	+53.46%
Mar 31, 2025	CITADEL ADVISORS LLC	0.43%	489.69K	2.93M	392.03K	+401.41%
Mar 31, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.42%	481.24K	2.88M	24.19K	+5.29%
Mar 31, 2025	BLACKROCK, INC.	7.22%	8.18M	48.97M	-163.7K	-1.96%
Mar 31, 2025	FMR LLC	15.07%	17.08M	102.29M	508.07K	+3.07%
Mar 31, 2025	TCG CROSSOVER MANAGEMENT, LLC	6.15%	6.96M	41.72M	0	0
Mar 31, 2025	VANGUARD GROUP INC	5.35%	6.06M	36.29M	-75.04K	-1.22%
Mar 31, 2025	REDMILE GROUP, LLC	2.84%	3.22M	19.26M	-338.81K	-9.53%
Mar 31, 2025	UBS GROUP AG	2.74%	3.1M	18.59M	2.89M	+1,350.98%
Mar 31, 2025	VESTAL POINT CAPITAL, LP	2.65%	3M	17.97M	3M	+100.00%
Mar 31, 2025	STATE STREET CORP	3.63%	4.12M	24.66M	198.67K	+5.07%
Mar 31, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	2.32%	2.63M	15.78M	2.86K	+0.11%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.13%	2.42M	14.47M	107.35K	+4.65%
Mar 31, 2025	NORTHERN TRUST CORP	0.78%	879.84K	5.27M	-32.88K	-3.60%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.73%	826.3K	4.95M	-6.86K	-0.82%
Mar 31, 2025	SUPERSTRING CAPITAL MANAGEMENT LP	0.68%	774.72K	4.64M	-136.14K	-14.95%
Mar 31, 2025		0.21%	233.85K	1.4M	233.85K	+100.00%
Mar 31, 2025	ALLIANCEBERNSTEIN L.P.	0.21%	233.82K	1.4M	-231.12K	-49.71%
Mar 31, 2025	OCTAGON CAPITAL ADVISORS LP	2.44%	2.76M	16.55M	0	0
Mar 31, 2025	SOFINNOVA INVESTMENTS, INC.	1.93%	2.18M	13.07M	1.36M	+165.09%
Mar 31, 2025	WOODLINE PARTNERS LP	1.49%	1.69M	10.11M	1.07M	+175.22%
Mar 31, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	0.83%	936.58K	5.61M	0	0
Mar 31, 2025	SATURN V CAPITAL MANAGEMENT LLC	1.31%	1.48M	8.87M	-18.41K	-1.23%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.45%	514.5K	3.08M	457.99K	+810.42%
Mar 31, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.27%	302.48K	1.81M	27.19K	+9.88%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.87%	988.96K	5.92M	124.07K	+14.35%
Mar 31, 2025	SG AMERICAS SECURITIES, LLC	0.84%	947.8K	5.68M	-16.92K	-1.75%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.23%	256.6K	1.54M	-2.17K	-0.84%
Mar 31, 2025	ROSALIND ADVISORS, INC.	0.22%	248.29K	1.49M	248.29K	+100.00%
Mar 31, 2024	INVESCO LTD.	0.05%	36.84K	247.58K	2.1K	+6.05%
Mar 31, 2024	CITIGROUP INC	0.75%	599.99K	4.03M	478.14K	+392.40%
Mar 31, 2024	PROSIGHT MANAGEMENT, LP	0.7%	555.5K	3.73M	555.5K	+100.00%
Mar 31, 2024	READYSTATE ASSET MANAGEMENT LP	0.67%	537.2K	3.61M	537.2K	+100.00%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.59%	473.39K	3.18M	401.74K	+560.72%
Mar 31, 2024	FARALLON CAPITAL MANAGEMENT LLC	0.58%	462K	3.1M	445K	+2,617.65%
Mar 31, 2024	D. E. SHAW & CO., INC.	0.57%	451.23K	3.03M	392.43K	+667.39%
Mar 31, 2024	GHOST TREE CAPITAL, LLC	0.56%	450K	3.02M	255K	+130.77%
Mar 31, 2024	AVIDITY PARTNERS MANAGEMENT LP	0.56%	445.71K	3M	445.71K	+100.00%
Mar 31, 2024	UBS GROUP AG	0.54%	431.01K	2.9M	203.6K	+89.53%
Mar 31, 2024	ALGERT GLOBAL LLC	0.46%	364.11K	2.45M	8.54K	+2.40%
Mar 31, 2024	SUVRETTA CAPITAL MANAGEMENT, LLC	0.4%	316K	2.12M	-3.39M	-91.48%
Mar 31, 2024	DEEP TRACK CAPITAL, LP	0.4%	316K	2.12M	316K	+100.00%
Mar 31, 2024	BLACKROCK INC.	8.4%	6.69M	44.95M	-65.97K	-0.98%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	2.23%	1.78M	11.94M	48.32K	+2.80%
Mar 31, 2024	SATURN V CAPITAL MANAGEMENT LLC	2%	1.6M	10.72M	838.34K	+110.79%
Mar 31, 2024	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.93%	1.53M	10.31M	445K	+40.85%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	1.75%	1.39M	9.37M	-242.64K	-14.82%
Mar 31, 2024	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.67%	1.33M	8.96M	1.33M	+100.00%
Mar 31, 2024	COMMODORE CAPITAL LP	8.07%	6.43M	43.18M	858.97K	+15.43%
Mar 31, 2024	STATE STREET CORP	9.57%	7.63M	51.25M	3.48M	+83.75%
Mar 31, 2024	FMR LLC	8.74%	6.96M	46.8M	1.66M	+31.34%
Mar 31, 2024	WELLS FARGO & COMPANY/MN	0.03%	26.85K	180.45K	3.13K	+13.19%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.04%	31.22K	209.83K	-8.32K	-21.04%
Mar 31, 2024	ENTRYPOINT CAPITAL, LLC	0.04%	31.29K	210.28K	-1.75K	-5.30%
Mar 31, 2024	ENTROPY TECHNOLOGIES, LP	0.04%	31.63K	212.57K	31.63K	+100.00%
Mar 31, 2024	XTX TOPCO LTD	0.04%	32.85K	220.76K	-50.57K	-60.62%
Mar 31, 2024	E FUND MANAGEMENT CO., LTD.	0.04%	33.31K	223.83K	17.9K	+116.13%
Mar 31, 2024	NEW YORK STATE COMMON RETIREMENT FUND	0.04%	33.92K	228K	13.36K	+64.98%
Mar 31, 2024	CORNERCAP INVESTMENT COUNSEL INC	0.04%	34.49K	231.8K	166	+0.48%
Mar 31, 2024	AMERICAN INTERNATIONAL GROUP, INC.	0.05%	40.94K	275.08K	-353	-0.86%
Mar 31, 2024	METLIFE INVESTMENT MANAGEMENT, LLC	0.05%	42.64K	286.55K	-213	-0.50%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.06%	47.8K	321.22K	47.8K	+100.00%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.07%	52.03K	349.64K	1.05K	+2.06%
Mar 31, 2024	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.07%	52.38K	445.78K	3.91K	+8.07%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.07%	54.12K	363.67M	-700	-1.28%
Mar 31, 2024	NEW YORK LIFE INVESTMENT MANAGEMENT LLC	0.08%	61.11K	410.67K	61.11K	+100.00%
Mar 31, 2024	CREDIT SUISSE AG/	0.08%	63.29K	425.3K	0	0
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.09%	72.2K	485.18K	0	0
Mar 31, 2024	JPMORGAN CHASE & CO	0.11%	86.6K	581.98K	-36.59K	-29.70%
Mar 31, 2024	FISHER ASSET MANAGEMENT, LLC	0.13%	101.53K	682.29K	-260	-0.26%
Mar 31, 2024	PROFUND ADVISORS LLC	0.14%	108.49K	729.03M	60.92K	+128.06%
Mar 31, 2024	RHUMBLINE ADVISERS	0.15%	119.13K	800.56K	3.18K	+2.74%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.15%	123.02K	826.67K	5.85K	+4.99%
Mar 31, 2024	SWISS NATIONAL BANK	0.16%	124K	833.28K	31.4K	+33.91%
Mar 31, 2024	LIGHTHOUSE INVESTMENT PARTNERS, LLC	0.21%	167.88K	1.13M	167.88K	+100.00%
Mar 31, 2024	PLATINUM INVESTMENT MANAGEMENT LTD	0.23%	186.25K	1.25M	-289.38K	-60.84%
Mar 31, 2024	MACQUARIE GROUP LTD	0.29%	230K	1.55M	0	0
Mar 31, 2024	NEW LEAF VENTURE PARTNERS, L.L.C.	0.31%	250.77K	1.69M	0	0
Mar 31, 2024	SECTORAL ASSET MANAGEMENT INC	0.33%	263.7K	1.77M	263.7K	+100.00%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.35%	280.81K	1.89M	-20.09K	-6.68%
Mar 31, 2024	ASSENAGON ASSET MANAGEMENT S.A.	0.75%	600.76K	4.04M	0	0
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.78%	619.04K	4.16M	13.01K	+2.15%
Mar 31, 2024	WOODLINE PARTNERS LP	0.88%	698.38K	4.69M	-92.11K	-11.65%
Mar 31, 2024	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	1.18%	936.58K	6.29M	-1.06M	-53.06%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	1.28%	1.02M	6.87M	777.34K	+317.61%
Mar 31, 2024	SILVERARC CAPITAL MANAGEMENT, LLC	1.3%	1.04M	6.97M	69.92K	+7.23%
Mar 31, 2024	REDMILE GROUP, LLC	4.97%	3.96M	26.63M	1.05M	+35.98%
Mar 31, 2024	FAIRMOUNT FUNDS MANAGEMENT LLC	5.93%	4.73M	31.76M	1.17M	+32.78%
Mar 31, 2024	VR ADVISER, LLC	6.44%	5.13M	34.47M	445K	+9.50%
Mar 31, 2024	VANGUARD GROUP INC	7.24%	5.77M	38.75M	1.23M	+27.15%
Mar 31, 2024	TCG CROSSOVER MANAGEMENT, LLC	7.8%	6.21M	41.76M	583.33K	+10.36%
Mar 31, 2024	POINT72 ASSET MANAGEMENT, L.P.	8.38%	6.68M	44.86M	1.48M	+28.60%
Mar 31, 2024	CRESTLINE MANAGEMENT, LP	0.4%	315K	2.12M	315K	+100.00%
Mar 31, 2024	PANAGORA ASSET MANAGEMENT INC	0.39%	307.25K	2.06M	307.25K	+100.00%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.38%	299.67K	2.01M	273.4K	+1,040.81%
Mar 31, 2024	WELLINGTON MANAGEMENT GROUP LLP	0.37%	296.31K	1.99M	168.87K	+132.50%
Mar 31, 2024	KYNAM CAPITAL MANAGEMENT, LP	10.67%	8.5M	57.12M	2.65M	+45.18%
Mar 31, 2024	SOFINNOVA INVESTMENTS, INC.	3.01%	2.4M	16.13M	2.4M	+100.00%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	2.96%	2.36M	15.83M	-441.32K	-15.78%
Mar 31, 2024	VIVO CAPITAL, LLC	2.82%	2.24M	15.09M	0	0
Mar 31, 2024	JANUS HENDERSON GROUP PLC	2.64%	2.1M	14.1M	2.08M	+12,785.82%
Mar 31, 2024	MORGAN STANLEY	2.32%	1.85M	12.44M	-408.49K	-18.08%
Mar 31, 2024	PERCEPTIVE ADVISORS LLC	1.11%	883.33K	5.94M	-239.63K	-21.34%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	1.09%	871.2K	5.85M	424.43K	+95.00%
Mar 31, 2024	NANTAHALA CAPITAL MANAGEMENT, LLC	0.99%	790.94K	5.32M	150K	+23.40%
Mar 31, 2024	5AM VENTURE MANAGEMENT, LLC	0.99%	790.44K	5.31M	0	0
Mar 31, 2024	NORTHERN TRUST CORP	0.9%	715.09K	4.81M	1.51K	+0.21%
Mar 31, 2024	KENNEDY CAPITAL MANAGEMENT LLC	0.89%	705.63K	4.74M	385.32K	+120.29%
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	0.88%	704.86K	4.74M	416.19K	+144.17%
Dec 31, 2023	STATE STREET CORP	4.82%	4.15M	24.41M	1.18M	+39.86%
Dec 31, 2023	VANGUARD GROUP INC	5.26%	4.53M	26.66M	161.34K	+3.69%
Dec 31, 2023	VR ADVISER, LLC	5.44%	4.68M	27.54M	0	0
Dec 31, 2023	POINT72 ASSET MANAGEMENT, L.P.	6.02%	5.19M	30.53M	1.42M	+37.82%
Dec 31, 2023	FMR LLC	6.15%	5.3M	31.18M	733.07K	+16.04%
Dec 31, 2023	COMMODORE CAPITAL LP	6.46%	5.57M	32.73M	0	0
Dec 31, 2023	TCG CROSSOVER MANAGEMENT, LLC	6.54%	5.63M	33.11M	0	0
Dec 31, 2023	KYNAM CAPITAL MANAGEMENT, LP	6.79%	5.85M	34.43M	3.64M	+164.91%
Dec 31, 2023	BLACKROCK INC.	7.84%	6.76M	39.72M	608.51K	+9.90%
Dec 31, 2023	SCHRODER INVESTMENT MANAGEMENT GROUP	0.16%	135K	793.8K	135K	+100.00%
Dec 31, 2023	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.21%	179.42K	1.06M	158.08K	+740.94%
Dec 31, 2023	GHOST TREE CAPITAL, LLC	0.23%	195K	1.15M	-455K	-70.00%
Dec 31, 2023	UBS GROUP AG	0.26%	227.41K	1.34M	148.33K	+187.59%
Dec 31, 2023	BARCLAYS PLC	0.27%	229.21K	1.35M	118.29K	+106.65%
Dec 31, 2023	MACQUARIE GROUP LTD	0.27%	230K	1.35M	0	0
Dec 31, 2023	CANDRIAM S.C.A.	0.27%	232.49K	1.37M	-545K	-70.10%
Dec 31, 2023	WOODLINE PARTNERS LP	0.92%	790.48K	4.65M	670.48K	+558.74%
Dec 31, 2023	SILVERARC CAPITAL MANAGEMENT, LLC	1.12%	966.75K	5.68M	315.38K	+48.42%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	1.9%	1.64M	9.62M	57.14K	+3.62%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	2.01%	1.73M	10.17M	81.54K	+4.95%
Dec 31, 2023	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	2.32%	2M	11.73M	493.88K	+32.90%
Dec 31, 2023	EVENTIDE ASSET MANAGEMENT, LLC	2.59%	2.23M	13.13M	82.97K	+3.86%
Dec 31, 2023	VIVO CAPITAL, LLC	2.61%	2.24M	13.2M	0	0
Dec 31, 2023	MORGAN STANLEY	2.62%	2.26M	13.28M	2.13M	+1,644.57%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	3.25%	2.8M	16.45M	2.67M	+2,161.51%
Dec 31, 2023	REDMILE GROUP, LLC	3.38%	2.91M	17.13M	860.69K	+41.92%
Dec 31, 2023	SUVRETTA CAPITAL MANAGEMENT, LLC	4.31%	3.71M	21.82M	657.24K	+21.53%
Dec 31, 2023	FAIRMOUNT FUNDS MANAGEMENT LLC	4.13%	3.56M	20.93M	0	0
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.28%	244.75K	1.44M	23.37K	+10.56%
Dec 31, 2023	NEW LEAF VENTURE PARTNERS, L.L.C.	0.29%	250.77K	1.47M	-250.77K	-50.00%
Dec 31, 2023	SPHERA FUNDS MANAGEMENT LTD.	0.3%	259.2K	1.52M	-160.8K	-38.29%
Dec 31, 2023	SCHONFELD STRATEGIC ADVISORS LLC	0.3%	260.96K	1.53M	23.43K	+9.86%
Dec 31, 2023	HIGHVISTA STRATEGIES LLC	0.33%	281.09K	1.65M	82.51K	+41.55%
Dec 31, 2023	RAFFERTY ASSET MANAGEMENT, LLC	0.34%	288.67K	1.7M	96.89K	+50.52%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.35%	300.9K	1.77M	12.69K	+4.40%
Dec 31, 2023	SG AMERICAS SECURITIES, LLC	0.37%	317.41K	1.87M	212.69K	+203.10%
Dec 31, 2023	KENNEDY CAPITAL MANAGEMENT LLC	0.37%	320.32K	1.88M	53.78K	+20.18%
Dec 31, 2023	ALGERT GLOBAL LLC	0.41%	355.57K	2.09M	252.5K	+244.96%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.52%	446.77K	2.63M	46.89K	+11.73%
Dec 31, 2023	PLATINUM INVESTMENT MANAGEMENT LTD	0.55%	475.63K	2.8M	-203	-0.04%
Dec 31, 2023	POLAR ASSET MANAGEMENT PARTNERS INC.	0.57%	495.2K	2.91M	495.2K	+100.00%
Dec 31, 2023	ASSENAGON ASSET MANAGEMENT S.A.	0.7%	600.76K	3.53M	-8.13K	-1.34%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.7%	606.03K	3.56M	13.54K	+2.28%
Dec 31, 2023	PERCEPTIVE ADVISORS LLC	1.3%	1.12M	6.6M	-1.19M	-51.38%
Dec 31, 2023	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.26%	1.09M	6.41M	0	0
Dec 31, 2023	5AM VENTURE MANAGEMENT, LLC	0.92%	790.44K	4.65M	0	0
Dec 31, 2023	SATURN V CAPITAL MANAGEMENT LLC	0.88%	756.68K	4.45M	-1.02M	-57.38%
Dec 31, 2023	CITADEL ADVISORS LLC	0.74%	640.77K	3.77M	580.17K	+957.29%
Dec 31, 2023	NORTHERN TRUST CORP	0.83%	713.59K	4.2M	725	+0.10%
Dec 31, 2023	NANTAHALA CAPITAL MANAGEMENT, LLC	0.74%	640.94K	3.77M	65.94K	+11.47%

Insiders

Among the COGT insiders holding of 0.04% of the stake in company, FROST PHILLIP MD ET AL, , holds the largest shares of 15.73M. SCHULKE RYAN, Chief Executive Officer, is the second largest COGT insider with ownership of 6.36M shares. FAIRMOUNT FUNDS MANAGEMENT LLC, director, stands third with possession of 5.5M shares of that stake.

Insiders	Designation	Shares Held
FROST PHILLIP MD ET AL		15.73M
SCHULKE RYAN	Chief Executive Officer	6.36M
FAIRMOUNT FUNDS MANAGEMENT LLC	director	5.5M
CONLIN MATTHEW	President	4.44M
ATLAS VENTURE FUND IX, L.P.	10 percent owner	3.36M
BOOTH BRUCE	director	3.36M
CAMPANA DARIO	10 percent owner	3.1M
RATCLIFFE LIAM	director	897.77K
DUBNER DEREK	Chief Executive Officer	589.51K
FMR LLC		452.12K
REILLY JAMES PATRICK	President	379.95K
FRIED ROBERT N	director	337.34K
ROBINSON JOHN EDWARD	Chief Scientific Officer	140K
SACHS JESSICA	Chief Medical Officer	133.94K
GREEN JOHN L.	Chief Financial Officer	131.83K
JORDAN HARRY BAKER III	Chief Operating Officer	110K
KEARNS EVAN	Chief Legal Officer	109.4K
KIM PAUL	Chief Financial Officer	50K
PINNOW COLE	Chief Commercial Officer	45.85K
MACLACHLAN DANIEL	Chief Financial Officer	3.5K
BOLGER JOHN C	director	0
HSIEH MING	Chief Executive Officer	0
ETTENBERG SETH	Chief Scientific Officer	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Jan 22, 2026	FAIRMOUNT FUNDS MANAGEMENT LLC	SALE	36.40	3.5M	127.4M	5.5M
Dec 26, 2025	KEARNS EVAN	SALE	38.70	65K	2.52M	109.4K
Dec 26, 2025	SACHS JESSICA	SALE	38.70	82.64K	3.2M	133.94K
Dec 26, 2025	ROBINSON JOHN EDWARD	SALE	38.74	90K	3.49M	140K
Dec 26, 2025	GREEN JOHN L.	SALE	38.68	77K	2.98M	131.83K
Jul 10, 2025	FAIRMOUNT FUNDS MANAGEMENT LLC	PURCHASE	9.00	2.78M	25M	9M
Jan 14, 2025	PINNOW COLE	PURCHASE	7.60	43.75K	332.41K	45.85K
Jun 09, 2023	FAIRMOUNT FUNDS MANAGEMENT LLC	PURCHASE	12.00	800K	9.6M	3.27M
Jun 16, 2022	FAIRMOUNT FUNDS MANAGEMENT LLC	PURCHASE	8.25	1.2M	9.9M	2.47M
Apr 26, 2021	GREEN JOHN L.	SALE	8.86	17.81K	157.82K	3.84K
May 12, 2020	CAMPANA DARIO	SALE	0.46	98.2K	45.55K	3.1M
May 11, 2020	CAMPANA DARIO	SALE	0.45	77.72K	35.16K	3.19M
May 08, 2020	CAMPANA DARIO	SALE	0.46	100K	46.39K	3.29M
May 07, 2020	CAMPANA DARIO	SALE	0.41	100K	41.43K	3.39M
May 06, 2020	CAMPANA DARIO	SALE	0.40	1.8K	721.62	3.49M
May 05, 2020	CAMPANA DARIO	SALE	0.40	135.48K	54.44K	3.5M
May 04, 2020	CAMPANA DARIO	SALE	0.40	4.8K	1.92K	3.63M
May 01, 2020	CAMPANA DARIO	SALE	0.41	800	328	3.64M
Apr 30, 2020	CAMPANA DARIO	SALE	0.40	75.99K	30.56K	3.64M
Apr 29, 2020	CAMPANA DARIO	SALE	0.41	382.93K	155.51K	3.71M
Apr 28, 2020	CAMPANA DARIO	SALE	0.41	15.05K	6.17K	4.1M
Apr 27, 2020	CAMPANA DARIO	SALE	0.40	242.58K	97.81K	4.11M
Apr 20, 2020	CAMPANA DARIO	SALE	0.40	12.61K	5.05K	4.35M
Apr 17, 2020	CAMPANA DARIO	SALE	0.39	65.54K	25.57K	4.37M
Apr 16, 2020	CAMPANA DARIO	SALE	0.38	600	229.56	4.43M
Apr 15, 2020	CAMPANA DARIO	SALE	0.38	82.78K	31.8K	4.43M
Apr 14, 2020	CAMPANA DARIO	SALE	0.40	44.01K	17.6K	4.51M
Apr 09, 2020	CAMPANA DARIO	SALE	0.33	420.29K	138.15K	4.61M
Apr 08, 2020	CAMPANA DARIO	SALE	0.35	100	35.1	5.03M
Apr 07, 2020	CAMPANA DARIO	SALE	0.35	11.4K	3.99K	5.03M
Apr 06, 2020	CAMPANA DARIO	SALE	0.35	50.08K	17.53K	5.05M
Mar 25, 2019	ETTENBERG SETH	SALE	4.12	11.49K	47.33K	0
Feb 25, 2019	ETTENBERG SETH	SALE	4.25	11.49K	48.85K	0
Dec 26, 2018	ETTENBERG SETH	SALE	4.05	11.49K	46.49K	0
Nov 26, 2018	ETTENBERG SETH	SALE	7.00	11.49K	80.44K	0
Oct 25, 2018	ETTENBERG SETH	SALE	8.46	11.49K	97.2K	0
Sep 25, 2018	ETTENBERG SETH	SALE	12.47	11.49K	143.18K	0
Apr 03, 2018	ATLAS VENTURE FUND IX, L.P.	PURCHASE	12.00	94.05K	1.13M	3.36M
Apr 03, 2018	RATCLIFFE LIAM	PURCHASE	12.00	275K	3.3M	897.77K
Apr 03, 2018	BOOTH BRUCE	PURCHASE	12.00	94.05K	1.13M	3.36M
Apr 03, 2018	FMR LLC	PURCHASE	12.00	94.05K	1.13M	452.12K
Mar 29, 2018	CONLIN MATTHEW	PURCHASE	2.51	26.9K	67.52K	4.44M
Mar 29, 2018	SCHULKE RYAN	PURCHASE	2.54	100K	254K	6.36M
Mar 28, 2018	SCHULKE RYAN	PURCHASE	2.58	100K	258K	6.26M
Mar 28, 2018	CONLIN MATTHEW	PURCHASE	2.60	13.1K	34.06K	4.41M
Feb 13, 2018	CONLIN MATTHEW	PURCHASE	2.81	20K	56.2K	4.4M
Feb 13, 2018	SCHULKE RYAN	PURCHASE	2.93	100K	293K	6.16M
Dec 14, 2017	MACLACHLAN DANIEL	PURCHASE	3.74	500	1.87K	3.5K
Dec 14, 2017	DUBNER DEREK	PURCHASE	3.73	1K	3.73K	589.51K
Dec 08, 2017	FROST PHILLIP MD ET AL	PURCHASE	3.95	10K	39.5K	15.73M
Nov 15, 2017	FROST PHILLIP MD ET AL	PURCHASE	4.11	20K	82.2K	15.72M
Sep 13, 2017	DUBNER DEREK	SALE	4.70	14.1K	66.27K	588.51K
Sep 13, 2017	MACLACHLAN DANIEL	SALE	4.71	118.2K	556.71K	301.75K
Sep 13, 2017	REILLY JAMES PATRICK	SALE	4.70	14K	65.8K	379.95K
Sep 12, 2017	DUBNER DEREK	SALE	4.83	30K	144.9K	602.61K
Sep 12, 2017	MACLACHLAN DANIEL	SALE	4.80	1.24K	5.97K	419.94K
Sep 12, 2017	REILLY JAMES PATRICK	SALE	4.86	50K	243K	393.95K
Sep 11, 2017	DUBNER DEREK	SALE	5.25	15.2K	79.8K	632.61K
Sep 11, 2017	MACLACHLAN DANIEL	SALE	5.25	16K	84K	421.19K
Sep 11, 2017	REILLY JAMES PATRICK	SALE	5.25	14.8K	77.7K	443.95K
Mar 22, 2017	JORDAN HARRY BAKER III	PURCHASE	3.39	10K	33.9K	110K
Mar 22, 2017	DUBNER DEREK	PURCHASE	3.39	1K	3.39K	293.85K
Mar 14, 2017	JORDAN HARRY BAKER III	PURCHASE	3.60	20K	72K	100K
Mar 14, 2017	DUBNER DEREK	PURCHASE	3.59	1K	3.59K	292.85K
Jan 26, 2017	SCHULKE RYAN	PURCHASE	3.95	15K	59.25K	6.06M
Jan 23, 2017	SCHULKE RYAN	PURCHASE	3.15	150K	472.5K	6.05M
Jan 23, 2017	CONLIN MATTHEW	PURCHASE	3.15	100K	315K	5.46M
Nov 30, 2016	JORDAN HARRY BAKER III	PURCHASE	3.25	5K	16.25K	80K
Nov 29, 2016	SCHULKE RYAN	PURCHASE	3.79	2K	7.58K	5.9M
Nov 09, 2016	SCHULKE RYAN	PURCHASE	3.72	5K	18.6K	5.89M
Nov 09, 2016	CONLIN MATTHEW	PURCHASE	3.73	5K	18.65K	5.35M
Nov 08, 2016	CONLIN MATTHEW	PURCHASE	4.01	5K	20.05K	5.35M
Nov 08, 2016	SCHULKE RYAN	PURCHASE	4.01	5K	20.05K	5.89M
Nov 07, 2016	FRIED ROBERT N	PURCHASE	3.75	2K	7.5K	337.34K
Nov 07, 2016	SCHULKE RYAN	PURCHASE	3.51	20.68K	72.58K	5.88M
Nov 07, 2016	MACLACHLAN DANIEL	PURCHASE	3.45	1K	3.45K	3K
Nov 07, 2016	DUBNER DEREK	PURCHASE	3.66	3K	10.97K	51.85K
Nov 07, 2016	CONLIN MATTHEW	PURCHASE	3.51	21.81K	76.56K	5.34M
Nov 07, 2016	JORDAN HARRY BAKER III	PURCHASE	3.93	75K	294.75K	75K
Nov 07, 2016	FROST PHILLIP MD ET AL	PURCHASE	3.68	10K	36.8K	15.7M
Nov 04, 2016	FROST PHILLIP MD ET AL	PURCHASE	2.97	25K	74.25K	15.69M
Oct 25, 2016	FROST PHILLIP MD ET AL	PURCHASE	3.42	5K	17.1K	15.67M
Oct 19, 2016	FROST PHILLIP MD ET AL	PURCHASE	3.46	25K	86.55K	15.66M
Oct 08, 2010	HSIEH MING	SALE	10.50	1.86M	19.53M	0
Dec 01, 2009	KIM PAUL	SALE	8.67	15.83K	137.25K	50K
Aug 24, 2009	BOLGER JOHN C	SALE	10.73	10K	107.3K	0
Dec 01, 2008	HSIEH MING	SALE	12.73	50K	636.75K	1.86M
Dec 01, 2008	KIM PAUL	SALE	13.02	16.06K	209.13K	75K
Nov 28, 2008	HSIEH MING	SALE	13.07	50K	653.45K	1.91M
Aug 14, 2008	KIM PAUL	SALE	11.61	120K	1.39M	100K
Aug 13, 2008	KIM PAUL	SALE	11.48	133.51K	1.53M	100K
May 12, 2008	KIM PAUL	SALE	10.67	2.1K	22.41K	100K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES3.81M5

NET SHARES-3.81M5

SHARES HELD6.02M5

% NET SHARES-163.38%0%

Frequently Asked Questions