How many institutions own CBIO stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own CBIO shares is 34, representing 77.39% of the company's common stock.

Who are the major shareholders selling Crescent Biopharma, Inc. stock?

GOLDMAN SACHS GROUP INC, in the last quarter, reduced its stake in CBIO by -31.72% restricting it's holding to 25.25 thousand shares of worth nearly $299.41K. VANGUARD GROUP INC also lessened -15.26% of the CBIO shares from its portfolio, reducing its holding to 557.51 thousand shares of worth $6.61M. MANUFACTURERS LIFE INSURANCE COMPANY, THE also shunned CBIO shares holding by -0.08% last quarter which brought its holding to 24.9 thousand shares worth $288.95K.

Investors who are buying CBIO stock?

As per its latest 13F filing, HRT FINANCIAL LP increased its stake in CBIO by 100% in the last quarter. The institutional holder raised its holding to 13.08 thousand shares having worth more than $155.00K. MILLENNIUM MANAGEMENT LLC also added 100% more shares of CBIO to its portfolio, raising its holding to 61.88 thousand shares of worth $733.92K. SUSQUEHANNA INTERNATIONAL GROUP, LLP also increased its CBIO shares holding by 100% which brought its holding to 57.05 thousand shares worth $676.59K.

CBIO's major insiders: who are they?

The insider with the most stakes in CBIO is Fairmount Funds Management LLC , at the company. Additionally, CBIO stock is highly held by 10 percent owner BVF PARTNERS L P/IL and 10 percent owner Flynn James E among others.

Did an insider recently sell CBIO stock?

Company executives, directors, and other insiders own 6.61% percent of Crescent Biopharma, Inc.'s stock. Within the last six months, there have been 0 transaction(s) in which CBIO insiders have sold stock, totaling 0 shares. Insiders that have sold shares include LAWLOR AUGUSTINE, LEVY HOWARD, and FLYNN JAMES E.

Which insider recently purchased CBIO stock?

There have been 1 transaction(s) during the past 6-months in which Crescent Biopharma, Inc. insiders have bought stock, totalling 131434 shares

How much of CBIO does insiders own?

Around 1.77M Crescent Biopharma, Inc. shares are held by insiders, which represents about 6.61% of CBIO stock.

Who is the insider with the largest stake?

CBIO , Fairmount Funds Management LLC holds the largest portfolio of the company's shares. CBIO shares owned by Fairmount total nearly 1.77 million.

Which institution holds the most shares in CBIO?

HRT FINANCIAL LP is the largest institutional owner in CBIO which holds 13.08 thousand shares worth $155.00K or 0.01% of the total CBIO shares outstanding followed by MILLENNIUM MANAGEMENT LLC with ownership of 61.88 thousand shares representing 0.07% of the CBIO ownership. SUSQUEHANNA INTERNATIONAL GROUP, LLP is the third largest stakeholder with 57.05 thousand shares or 0.06% of the ownership worth more than $676.59K.

Is Crescent Biopharma, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the CBIO is concerned, it is a stock which is not optionable.

Is there a short position on CBIO's shares?

Number of CBIO shares short is null. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding CBIO shares are there?

As of today, null shares of CBIO are outstanding.

Is there many float in CBIO stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, CBIO has null shares in float.

CBIO short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for CBIO is null.

Crescent Biopharma (CBIO) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableNo

Short Percent Of Outstanding SharesN/A

Short Percent Of FloatN/A

Shares OutstandingN/A

Shares FloatN/A

Shares ShortN/A

Short RatioN/A

N/A

Short % of Float

N/A

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

6.61% Percentage of Shares held by All Insiders

77.39% Percentage of Shares held by All Institutions

82.88% Percentage of Float held by Institutions

Number of Institutions Holding Shares

Institutional Ownership

About 77.39% of CBIO shares are held by financial institutions. HRT FINANCIAL LP is the top corporate investor, holding 13.08K shares valued at $155.00K. A 0.01% stake in Crescent Biopharma, Inc. is owned by the company. MILLENNIUM MANAGEMENT LLC owns 61.88K shares valued at $733.92K, which translates its holding of 0.07% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	HRT FINANCIAL LP	0.01%	13.08K	155K	13.08K	+100.00%
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	0.07%	61.88K	733.92K	61.88K	+100.00%
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.06%	57.05K	676.59K	57.05K	+100.00%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	0.03%	25.25K	299.41K	-11.73K	-31.72%
Dec 31, 2025	DEEP TRACK CAPITAL, LP	0.5%	453.69K	5.38M	0	0
Dec 31, 2025	VANGUARD GROUP INC	0.61%	557.51K	6.61M	-100.39K	-15.26%
Dec 31, 2025	STONEPINE CAPITAL MANAGEMENT, LLC	0.1%	87.68K	1.04M	87.68K	+100.00%
Dec 31, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.03%	24.9K	288.95K	-20	-0.08%
Dec 31, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	0%	0	-	-272.95K	-100.00%
Dec 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.29%	264K	3.11M	264K	+100.00%
Dec 31, 2025	JEFFERIES FINANCIAL GROUP INC.	0.07%	64.24K	761.93K	-38.47K	-37.45%
Dec 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.05%	46.7K	553.86K	19.8K	+73.61%
Dec 31, 2025	TWO SIGMA ADVISERS, LP	0.04%	32.5K	385.45K	32.5K	+100.00%
Dec 31, 2025	MORGAN STANLEY	0.03%	27.52K	326.4K	27.38K	+18,880.00%
Dec 31, 2025	STATE STREET CORP	0.03%	26.22K	310.93K	7.6K	+40.82%
Dec 31, 2025	LOGOS GLOBAL MANAGEMENT LP	0.66%	600K	7.12M	0	0
Dec 31, 2025	TWO SIGMA INVESTMENTS, LP	0.14%	125.22K	1.49M	96.91K	+342.21%
Dec 31, 2025	FMR LLC	4.55%	4.13M	49.02M	2.72M	+192.19%
Dec 31, 2025	BVF INC/IL	3.03%	2.75M	32.6M	1.36M	+98.06%
Dec 31, 2025	FAIRMOUNT FUNDS MANAGEMENT LLC	3.02%	2.75M	32.59M	1.36M	+97.99%
Dec 31, 2025	VR ADVISER, LLC	2.35%	2.13M	25.3M	745.71K	+53.73%
Dec 31, 2025	FCPM III SERVICES B.V.	1.85%	1.68M	19.9M	1.68M	+100.00%
Dec 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.67%	606K	7.19M	606K	+100.00%
Dec 31, 2025	PERCEPTIVE ADVISORS LLC	0.5%	453.69K	5.38M	0	0
Dec 31, 2025	RTW INVESTMENTS, LP	0.41%	372.86K	4.42M	372.86K	+100.00%
Dec 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.37%	338.13K	4.01M	-45.47K	-11.85%
Dec 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.33%	302.46K	3.59M	0	0
Dec 31, 2025	OMERS ADMINISTRATION CORP	0.01%	11.6K	137.58K	11.6K	+100.00%
Dec 31, 2025	UBS GROUP AG	0.01%	7.13K	84.5K	-5.54K	-43.72%
Dec 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.33%	300K	3.56M	300K	+100.00%
Dec 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.16%	143.41K	1.63M	125.71K	+710.33%
Dec 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.12%	111.72K	1.32M	111.72K	+100.00%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	0.01%	5.57K	66.1K	1.71K	+44.27%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0%	3.59K	42.52K	3.58K	+89,525.00%
Dec 31, 2025	CITIGROUP INC	0%	623	7.39K	-175	-21.93%
Dec 31, 2025	VESTAL POINT CAPITAL, LP	1.65%	1.5M	17.79M	1.5M	+100.00%
Dec 31, 2025	OPALEYE MANAGEMENT INC.	1.3%	1.18M	13.97M	1.18M	+100.00%
Dec 31, 2025	TANG CAPITAL MANAGEMENT LLC	0.96%	872.4K	10.35M	192.57K	+28.33%
Dec 31, 2025	BLACKROCK, INC.	0.12%	109.23K	1.3M	115	+0.11%
Dec 31, 2025	BOXER CAPITAL MANAGEMENT, LLC	0.5%	453.69K	5.38M	0	0
Dec 31, 2025		0.41%	372.86K	4.42B	372.86K	+100.00%
Dec 31, 2025	HEIGHTS CAPITAL MANAGEMENT, INC	0.29%	264K	3.13M	264K	+100.00%
Dec 31, 2025	JANE STREET GROUP, LLC	0.03%	22.97K	272.37K	22.97K	+100.00%
Dec 31, 2025	JPMORGAN CHASE & CO	0.01%	23.34K	276.8K	23.32K	+137,188.24%
Dec 31, 2025	TOWER RESEARCH CAPITAL LLC (TRC)	0%	409	4.85M	209	+104.50%
Dec 31, 2025	SBI SECURITIES CO., LTD.	0%	68	806	0	0
Dec 31, 2025	ADVISOR GROUP HOLDINGS, INC.	0%	26	308	0	0
Dec 31, 2025	GROUP ONE TRADING, L.P.	0%	4	47	-78	-95.12%
Dec 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0%	0	-	-200.01K	-100.00%
Dec 31, 2025	CITADEL ADVISORS LLC	0%	0	-	-25.59K	-100.00%
Dec 31, 2025	AFFINITY ASSET ADVISORS, LLC	0%	0	-	-18K	-100.00%
Dec 31, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0%	0	-	-200K	-100.00%
Dec 31, 2025	COMMODORE CAPITAL LP	0%	0	-	-450.83K	-100.00%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.1%	91.08K	1.08M	21.95K	+31.74%
Dec 31, 2025	BLACKSTONE INC.	0.08%	75.61K	896.78K	0	0
Dec 31, 2025	WOODLINE PARTNERS LP	0.08%	74K	877.64K	74K	+100.00%
Dec 31, 2025	BURKEHILL GLOBAL MANAGEMENT, LP	0.08%	74K	844.34K	74K	+100.00%
Dec 31, 2025	MOORE CAPITAL MANAGEMENT, LP	0.03%	25K	296.5K	25K	+100.00%
Dec 31, 2025	MARSHALL WACE, LLP	0.02%	21.83K	258.86K	-21.87K	-50.05%
Dec 31, 2025	NORTHERN TRUST CORP	0.02%	17.23K	204.34K	413	+2.46%
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0%	28.32K	336.7K	28.32K	+100.00%
Sep 30, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.01%	200K	2.38M	-200K	-50.00%
Sep 30, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0%	24.92K	296.33K	24.92K	+100.00%
Sep 30, 2025	FMR LLC	0.04%	1.41M	16.82M	490	+0.03%
Sep 30, 2025	VANGUARD GROUP INC	0.02%	657.9K	7.82M	657.9K	+100.00%
Sep 30, 2025	BVF INC/IL	0.04%	1.39M	16.5M	0	0
Sep 30, 2025	TOWER RESEARCH CAPITAL LLC (TRC)	0%	200	2.38K	200	+100.00%
Sep 30, 2025	MORGAN STANLEY	0%	145	1.72K	-15.25K	-99.06%
Sep 30, 2025	ADVISOR GROUP HOLDINGS, INC.	0%	26	374	26	+100.00%
Sep 30, 2025	JPMORGAN CHASE & CO	0%	17	202	17	+100.00%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0%	4	48	0	0
Sep 30, 2025	COMMODORE CAPITAL LP	0.01%	450.83K	5.36M	-2.86K	-0.63%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.01%	383.6K	4.56M	383.6K	+100.00%
Sep 30, 2025	JEFFERIES FINANCIAL GROUP INC.	0%	102.71K	1.22M	75.62K	+279.07%
Sep 30, 2025	BLACKSTONE INC.	0%	75.61K	899.05K	0	0
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	0%	69.13K	822.02K	69.13K	+100.00%
Sep 30, 2025	MARSHALL WACE, LLP	0%	43.69K	519.52K	43.69K	+100.00%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0%	3.86K	45.93K	-5.37K	-58.15%
Sep 30, 2025	BARCLAYS PLC	0%	0	-	-286	-100.00%
Sep 30, 2025	RAYMOND JAMES FINANCIAL INC	0%	0	-	-50	-100.00%
Sep 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	0%	0	-	-642.72K	-100.00%
Sep 30, 2025	SBI SECURITIES CO., LTD.	0%	68	809	0	0
Sep 30, 2025	PERCEPTIVE ADVISORS LLC	0.01%	453.69K	5.39M	0	0
Sep 30, 2025	GOLDMAN SACHS GROUP INC	0%	36.98K	439.63K	36.98K	+100.00%
Sep 30, 2025	BRAIDWELL LP	0%	0	-	-261.5K	-100.00%
Sep 30, 2025	GROUP ONE TRADING, L.P.	0%	82	975	-80	-49.38%
Sep 30, 2025	DEEP TRACK CAPITAL, LP	0.01%	453.69K	5.39M	0	0
Sep 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.01%	302.46K	3.6M	0	0
Sep 30, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	0.01%	272.95K	3.25M	-180.73K	-39.84%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.01%	200.01K	2.38M	99.09K	+98.20%
Sep 30, 2025	CITADEL ADVISORS LLC	0%	25.59K	304.3K	25.59K	+100.00%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0%	17.7K	210.43K	-162.19K	-90.16%
Sep 30, 2025	AFFINITY ASSET ADVISORS, LLC	0%	18K	214K	-262.03K	-93.57%
Sep 30, 2025	FAIRMOUNT FUNDS MANAGEMENT LLC	0.04%	1.39M	16.5M	0	0
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0%	26.9K	319.84K	26.9K	+100.00%
Sep 30, 2025	VR ADVISER, LLC	0.04%	1.39M	16.5M	0	0
Sep 30, 2025	LOGOS GLOBAL MANAGEMENT LP	0.02%	600K	7.13M	46.31K	+8.36%
Sep 30, 2025	STATE STREET CORP	0%	18.62K	221.36K	18.62K	+100.00%
Sep 30, 2025	BOXER CAPITAL MANAGEMENT, LLC	0.01%	453.69K	5.39M	0	0
Sep 30, 2025	UBS GROUP AG	0%	12.66K	150.54K	12.44K	+5,577.58%
Sep 30, 2025	CITIGROUP INC	0%	798	9.49K	798	+100.00%
Sep 30, 2025	BLACKROCK, INC.	0%	109.12K	1.3M	103.06K	+1,703.26%
Sep 30, 2025	NORTHERN TRUST CORP	0%	16.82K	199.94K	16.82K	+100.00%
Sep 30, 2025	TANG CAPITAL MANAGEMENT LLC	0.02%	679.82K	8.08M	629.67K	+1,255.53%
Jun 30, 2025	AFFINITY ASSET ADVISORS, LLC	0.01%	280.03K	4.52M	280.03K	+100.00%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0%	179.89K	2.9M	179.89K	+100.00%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0%	100.91K	1.63M	100.91K	+100.00%
Jun 30, 2025	BLACKSTONE INC.	0%	75.61K	1.22M	75.61K	+100.00%
Jun 30, 2025	TANG CAPITAL MANAGEMENT LLC	0%	50.15K	809.45K	50.15K	+100.00%
Jun 30, 2025	BLACKROCK, INC.	0%	6.05K	97.66K	6.05K	+100.00%
Jun 30, 2025	FMR LLC	0.04%	1.41M	22.83M	1.41M	+100.00%
Jun 30, 2025	FAIRMOUNT FUNDS MANAGEMENT LLC	0.04%	1.39M	22.4M	1.39M	+100.00%
Jun 30, 2025	MORGAN STANLEY	0%	15.39K	248.46K	15.39K	+100.00%
Jun 30, 2025	UBS GROUP AG	0%	223	3.6K	223	+100.00%
Jun 30, 2025	GROUP ONE TRADING, L.P.	0%	162	2.62K	162	+100.00%
Jun 30, 2025	VR ADVISER, LLC	0.04%	1.39M	22.4M	1.39M	+100.00%
Jun 30, 2025	BVF INC/IL	0.04%	1.39M	22.4M	1.39M	+100.00%
Jun 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	0.02%	642.72K	10.37M	642.72K	+100.00%
Jun 30, 2025	LOGOS GLOBAL MANAGEMENT LP	0.01%	553.69K	8.94M	553.69K	+100.00%
Jun 30, 2025	PERCEPTIVE ADVISORS LLC	0.01%	453.69K	7.32M	453.69K	+100.00%
Jun 30, 2025	COMMODORE CAPITAL LP	0.01%	453.69K	7.32M	453.69K	+100.00%
Jun 30, 2025	BOXER CAPITAL MANAGEMENT, LLC	0.01%	453.69K	7.32M	453.69K	+100.00%
Jun 30, 2025	SBI SECURITIES CO., LTD.	0%	68	1.1K	68	+100.00%
Jun 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.01%	302.46K	4.88M	302.46K	+100.00%
Jun 30, 2025	BRAIDWELL LP	0.01%	261.5K	4.22M	261.5K	+100.00%
Jun 30, 2025	JEFFERIES FINANCIAL GROUP INC.	0%	27.1K	437.33K	27.1K	+100.00%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0%	9.23K	148.99K	9.23K	+100.00%
Jun 30, 2025	BARCLAYS PLC	0%	286	4K	286	+100.00%
Jun 30, 2025		0.01%	68	1.1K	68	+100.00%
Jun 30, 2025	RAYMOND JAMES FINANCIAL INC	0%	50	807	50	+100.00%
Jun 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0%	4	65	4	+100.00%
Jun 30, 2025	DEEP TRACK CAPITAL, LP	0.01%	453.69K	7.32M	453.69K	+100.00%
Jun 30, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	0.01%	453.69K	7.32M	453.69K	+100.00%
Jun 30, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.01%	400K	6.46M	400K	+100.00%
Dec 31, 2024	PARALLEL ADVISORS, LLC	0%	15	182	15	+100.00%
Dec 31, 2023	CITADEL ADVISORS LLC	0%	0	-	-1.1K	-100.00%
Dec 31, 2023	JPMORGAN CHASE & CO	0%	0	-	-7.05K	-100.00%
Dec 31, 2023	ADVISORY SERVICES NETWORK, LLC	0%	66	1.7K	66	+100.00%
Dec 31, 2023	TOWER RESEARCH CAPITAL LLC (TRC)	0%	0	-	-4.02K	-100.00%
Dec 31, 2023	BARCLAYS PLC	0%	0	-	-60.2K	-100.00%
Dec 31, 2023	RAYMOND JAMES & ASSOCIATES	0%	0	-	-12.9K	-100.00%
Dec 31, 2023	BNP PARIBAS ARBITRAGE, SNC	0%	0	-	-277	-100.00%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	0%	0	-	-258.75K	-100.00%
Dec 31, 2023	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0%	0	-	-42.35K	-100.00%
Dec 31, 2023	TWO SIGMA SECURITIES, LLC	0%	0	-	-20.04K	-100.00%
Dec 31, 2023	NANTAHALA CAPITAL MANAGEMENT, LLC	0%	0	-	-67.8K	-100.00%
Dec 31, 2023	PARALLAX VOLATILITY ADVISERS, L.P.	0%	0	-	-13.1K	-100.00%
Dec 31, 2023	CUTLER GROUP LLC / CA	0%	0	-	-5.5K	-100.00%
Dec 31, 2023	ARETE WEALTH ADVISORS, LLC	0%	0	-	-10.85K	-100.00%
Dec 31, 2023	UBS GROUP AG	0%	0	-	-5.08K	-100.00%
Dec 31, 2023	COLORADO CAPITAL MANAGEMENT, INC.	0%	0	-	-34.17K	-100.00%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0%	0	-	-22.48K	-100.00%
Dec 31, 2023	WELLS FARGO & COMPANY/MN	0%	0	-	-201	-100.00%
Dec 31, 2023	NORTHERN TRUST CORP	0%	0	-	-86.41K	-100.00%
Dec 31, 2023	STATE STREET CORP	0%	0	-	-72.6K	-100.00%
Dec 31, 2023	VANGUARD GROUP INC	0%	0	-	-206.9K	-100.00%
Dec 31, 2023	JOHNSON & JOHNSON	0%	0	-	-66.95K	-100.00%
Dec 31, 2023	ADVISOR GROUP HOLDINGS, INC.	0%	0	-	-390	-100.00%
Dec 31, 2023	QUBE RESEARCH & TECHNOLOGIES LTD	0%	0	-	-22	-100.00%
Dec 31, 2023	KYNAM CAPITAL MANAGEMENT, LP	0%	0	-	-90.06K	-100.00%
Dec 31, 2023	HSBC HOLDINGS PLC	0%	0	-	-32.53K	-100.00%
Dec 31, 2023	MORGAN STANLEY	0%	0	-	-97.75K	-100.00%
Dec 31, 2023	ACADIAN ASSET MANAGEMENT LLC	0%	0	-	-63.79K	-100.00%
Dec 31, 2023	GROUP ONE TRADING, L.P.	0%	0	-	-46.78K	-100.00%
Dec 31, 2023	RENAISSANCE TECHNOLOGIES LLC	0%	0	-	-590.69K	-100.00%
Dec 31, 2023	BLACKROCK INC.	0%	0	-	-153.76K	-100.00%
Sep 30, 2023	COLORADO CAPITAL MANAGEMENT, INC.	0.09%	34.17K	16K	0	0
Sep 30, 2023	HSBC HOLDINGS PLC	0.09%	32.53K	15.71K	0	0
Sep 30, 2023	BANK OF AMERICA CORP /DE/	0.06%	22.48K	10.84K	-25.98K	-53.61%
Sep 30, 2023	TWO SIGMA SECURITIES, LLC	0.05%	20.04K	9.67K	20.04K	+100.00%
Sep 30, 2023	RAYMOND JAMES & ASSOCIATES	0.03%	12.9K	6.22K	0	0
Sep 30, 2023	MORGAN STANLEY	0.26%	97.75K	47.14K	21.65K	+28.45%
Sep 30, 2023	KYNAM CAPITAL MANAGEMENT, LP	0.24%	90.06K	43.44K	172	+0.19%
Sep 30, 2023	RENAISSANCE TECHNOLOGIES LLC	1.56%	590.69K	285K	-183.7K	-23.72%
Sep 30, 2023	ARETE WEALTH ADVISORS, LLC	0.03%	10.85K	5.23K	10.85K	+100.00%
Sep 30, 2023	JPMORGAN CHASE & CO	0.02%	7.05K	3.4K	7K	+13,461.54%
Sep 30, 2023	CUTLER GROUP LLC / CA	0.01%	5.5K	2K	0	0
Sep 30, 2023	UBS GROUP AG	0.01%	5.08K	2.45K	-20.9K	-80.45%
Sep 30, 2023	TOWER RESEARCH CAPITAL LLC (TRC)	0.01%	4.02K	1.94K	2.73K	+212.61%
Sep 30, 2023	ADVISOR GROUP HOLDINGS, INC.	0%	390	188	175	+81.40%
Sep 30, 2023	BNP PARIBAS ARBITRAGE, SNC	0%	277	134	0	0
Sep 30, 2023	WELLS FARGO & COMPANY/MN	0%	201	97	11	+5.79%
Sep 30, 2023	BLACKROCK INC.	0.41%	153.76K	74.16K	102	+0.07%
Sep 30, 2023	QUBE RESEARCH & TECHNOLOGIES LTD	0%	22	11	22	+100.00%
Sep 30, 2023	VIRTU FINANCIAL LLC	0%	0	-	-48.63K	-100.00%
Sep 30, 2023	CUBIST SYSTEMATIC STRATEGIES, LLC	0%	0	-	-14.68K	-100.00%
Sep 30, 2023	KEEBECK WEALTH MANAGEMENT, LLC	0%	0	-	-20K	-100.00%
Sep 30, 2023	GEODE CAPITAL MANAGEMENT, LLC	0.68%	258.75K	124.82K	-11.29K	-4.18%
Sep 30, 2023	VANGUARD GROUP INC	0.55%	206.9K	99.79K	206.9K	+100.00%
Sep 30, 2023	NORTHERN TRUST CORP	0.23%	86.41K	41.68K	0	0
Sep 30, 2023	STATE STREET CORP	0.19%	72.6K	35.02K	0	0
Sep 30, 2023	NANTAHALA CAPITAL MANAGEMENT, LLC	0.18%	67.8K	32.7K	0	0
Sep 30, 2023	JOHNSON & JOHNSON	0.18%	66.95K	32.29K	0	0
Sep 30, 2023	ACADIAN ASSET MANAGEMENT LLC	0.17%	63.79K	30K	-80.24K	-55.71%
Sep 30, 2023	BARCLAYS PLC	0.16%	60.2K	29K	0	0
Sep 30, 2023	CITADEL ADVISORS LLC	0%	1.1K	531	1.1K	+100.00%
Sep 30, 2023	GROUP ONE TRADING, L.P.	0.12%	46.78K	22.56K	-2.1K	-4.30%
Sep 30, 2023	PARALLAX VOLATILITY ADVISERS, L.P.	0.03%	13.1K	6.32K	0	0

Insiders

Among the CBIO insiders holding of 6.61% of the stake in company, FAIRMOUNT FUNDS MANAGEMENT LLC, , holds the largest shares of 1.77M. BVF PARTNERS L P/IL, 10 percent owner, is the second largest CBIO insider with ownership of 1.52M shares. FLYNN JAMES E, 10 percent owner, stands third with possession of 1.11M shares of that stake.

Insiders	Designation	Shares Held
FAIRMOUNT FUNDS MANAGEMENT LLC		1.77M
BVF PARTNERS L P/IL	10 percent owner	1.52M
FLYNN JAMES E	10 percent owner	1.11M
PAYNE FLETCHER	Chief Financial Officer	25.03K
USMAN NASSIM	President & CEO	24.54K
HILL STEPHEN A	director	20.71K
GNI GROUP LTD.	10 percent owner	13.15K
WILLIAMS EDDIE	director	10.84K
BLOUSE GRANT E.	Chief Scientific Officer	9.42K
CALDWELL WILLIAM S	SVP - Drug Discovery and Dev.	7.74K
CAI VERONICA	Controller	7.35K
MILLER SELINE E.	SVP Finance; Interim CFO & PAO	6.5K
BROWN JULIA R	director	6K
RICHARD JOHN P	director	3.72K
LING GEOFFREY M.D.	director	3K
MUSSO ALAN A	SVP, CFO & Treasurer	2.8K
HODGES MAURI K	VP Fin + Corp Sys & Controller	1.16K
LEVY HOWARD	Chief Medical Officer	639
BURRILL STEVEN	director	0
BRENNAN JEFFREY P	SVP - Bus. & Commercial Dev.	0
HICKS KAREN A	VP Human Resources	0
BENCHERIF MEROUANE	SVP, Preclinical Research	0
BARRETT M JAMES	10 percent owner	0
BARRIS PETER J	10 percent owner	0
SANDELL SCOTT D	10 percent owner	0
LAWLOR AUGUSTINE	director	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Dec 04, 2025	FAIRMOUNT FUNDS MANAGEMENT LLC	PURCHASE	0.00	131.43K	131.43	1.77M
Oct 27, 2023	GNI GROUP LTD.	PURCHASE	0.00	811	-	13.15K
Aug 09, 2022	BLOUSE GRANT E.	PURCHASE	0.47	3.25K	1.53K	9.42K
Aug 09, 2022	MILLER SELINE E.	PURCHASE	0.47	3.25K	1.53K	6.5K
Aug 09, 2022	USMAN NASSIM	PURCHASE	0.47	3.25K	1.53K	24.54K
Feb 09, 2022	USMAN NASSIM	PURCHASE	0.46	3.25K	1.5K	21.29K
Feb 09, 2022	MILLER SELINE E.	PURCHASE	0.46	3.25K	1.5K	3.25K
Feb 09, 2022	BLOUSE GRANT E.	PURCHASE	0.46	3.25K	1.5K	6.17K
Aug 09, 2021	LEVY HOWARD	PURCHASE	3.62	639	2.31K	639
Aug 09, 2021	USMAN NASSIM	PURCHASE	3.62	867	3.14K	18.04K
Aug 09, 2021	BLOUSE GRANT E.	PURCHASE	3.62	1.16K	4.21K	2.92K
Feb 09, 2021	LEVY HOWARD	PURCHASE	4.81	1.67K	8.03K	23.39K
Feb 09, 2021	USMAN NASSIM	PURCHASE	4.81	582	2.8K	12.17K
Aug 10, 2020	USMAN NASSIM	PURCHASE	4.81	582	2.8K	11.59K
Aug 10, 2020	LEVY HOWARD	PURCHASE	4.81	1.77K	8.5K	4.27K
Mar 16, 2020	LEVY HOWARD	PURCHASE	4.05	2.5K	10.13K	2.5K
Mar 13, 2020	RICHARD JOHN P	PURCHASE	3.98	2.5K	9.95K	3.72K
Mar 13, 2020	USMAN NASSIM	PURCHASE	3.91	4K	15.65K	11.01K
Mar 13, 2020	CAI VERONICA	PURCHASE	4.11	2K	8.22K	7.35K
Mar 04, 2020	WILLIAMS EDDIE	PURCHASE	5.78	2K	11.56K	10.84K
Feb 25, 2020	LING GEOFFREY M.D.	PURCHASE	6.23	3K	18.69K	3K
Feb 25, 2020	LAWLOR AUGUSTINE	SALE	6.10	69.4K	423.51K	0
May 24, 2019	RICHARD JOHN P	PURCHASE	8.03	1K	8.03K	1.22K
Nov 16, 2018	LEVY HOWARD	SALE	11.00	173	1.9K	7.56K
Mar 08, 2018	FLYNN JAMES E	SALE	29.03	8.12K	235.81K	1.11M
Mar 07, 2018	FLYNN JAMES E	SALE	30.00	10K	300K	1.12M
Mar 06, 2018	FLYNN JAMES E	SALE	31.18	39.3K	1.23M	1.13M
Dec 17, 2015	PAYNE FLETCHER	PURCHASE	2.00	10K	20K	25.03K
Dec 17, 2015	HILL STEPHEN A	PURCHASE	2.03	5K	10.15K	20.71K
Dec 17, 2015	USMAN NASSIM	PURCHASE	2.00	4K	8K	78.38K
Dec 05, 2013	BARRIS PETER J	SALE	5.13	1K	5.13K	0
Dec 05, 2013	SANDELL SCOTT D	SALE	5.13	1K	5.13K	0
Dec 05, 2013	BARRETT M JAMES	SALE	5.13	1K	5.13K	0
Dec 03, 2013	BARRETT M JAMES	SALE	5.38	15K	80.75K	0
Nov 21, 2013	BARRIS PETER J	SALE	5.16	5.33K	27.53K	1K
Nov 21, 2013	BARRETT M JAMES	SALE	5.16	5.33K	27.53K	1K
Nov 21, 2013	SANDELL SCOTT D	SALE	5.16	5.33K	27.53K	1K
May 10, 2013	BROWN JULIA R	PURCHASE	5.09	6K	30.53K	6K
Mar 11, 2013	HILL STEPHEN A	PURCHASE	4.38	10K	43.78K	20K
Mar 08, 2013	HILL STEPHEN A	PURCHASE	4.48	10K	44.8K	10K
Nov 16, 2012	BVF PARTNERS L P/IL	PURCHASE	5.11	26.8K	136.9K	1.52M
Nov 14, 2012	BVF PARTNERS L P/IL	PURCHASE	4.00	444.65K	1.78M	1.5M
Nov 08, 2012	BVF PARTNERS L P/IL	PURCHASE	4.01	17.4K	69.72K	1.05M
Nov 07, 2012	BVF PARTNERS L P/IL	PURCHASE	4.08	8.8K	35.91K	1.03M
Nov 02, 2012	BVF PARTNERS L P/IL	PURCHASE	4.05	21.5K	87.15K	1.03M
Nov 01, 2012	BVF PARTNERS L P/IL	PURCHASE	4.05	23.4K	94.69K	1M
Oct 31, 2012	BVF PARTNERS L P/IL	PURCHASE	4.06	5.3K	21.5K	981.16K
Jun 08, 2012	RICHARD JOHN P	PURCHASE	4.16	7.5K	31.19K	7.5K
Jul 01, 2011	RICHARD JOHN P	SALE	21.02	2.5K	52.55K	5.33K
Jun 07, 2011	MUSSO ALAN A	SALE	21.80	30.88K	672.97K	2.8K
May 13, 2011	BROWN JULIA R	SALE	23.38	9.1K	212.78K	0
May 12, 2011	BURRILL STEVEN	SALE	23.88	33.05K	789.34K	0
May 11, 2011	BURRILL STEVEN	SALE	23.88	33.05K	789.34K	0
May 10, 2011	BURRILL STEVEN	SALE	24.13	2K	48.25K	0
Apr 01, 2011	RICHARD JOHN P	SALE	26.60	2.5K	66.5K	5.33K
Mar 31, 2011	CALDWELL WILLIAM S	SALE	26.37	2.66K	70.01K	7.74K
Mar 09, 2011	HODGES MAURI K	SALE	30.00	1.5K	45K	1.16K
Mar 07, 2011	HODGES MAURI K	SALE	30.00	500	15K	1.16K
Mar 03, 2011	HODGES MAURI K	SALE	30.00	5.03K	150.9K	1.16K
Mar 02, 2011	HODGES MAURI K	SALE	30.00	200	6K	1.16K
Mar 01, 2011	BRENNAN JEFFREY P	SALE	30.00	1.26K	37.92K	0
Mar 01, 2011	HICKS KAREN A	SALE	30.00	1.24K	37.29K	0
Mar 01, 2011	HODGES MAURI K	SALE	30.16	12.7K	383.14K	1.16K
Mar 01, 2011	CALDWELL WILLIAM S	SALE	30.00	11.36K	340.8K	7.74K
Feb 28, 2011	CALDWELL WILLIAM S	SALE	28.00	15.48K	433.47K	7.74K
Feb 16, 2011	CALDWELL WILLIAM S	SALE	26.52	16.66K	441.66K	7.74K
Jan 19, 2011	BENCHERIF MEROUANE	SALE	27.09	30.2K	818.26K	0
Jan 19, 2011	RICHARD JOHN P	SALE	27.11	5K	135.54K	5.33K
Jan 18, 2011	RICHARD JOHN P	SALE	27.38	2.5K	68.44K	5.33K
Jan 18, 2011	BENCHERIF MEROUANE	SALE	27.17	22.8K	619.48K	0
Jan 14, 2011	HICKS KAREN A	SALE	27.50	1.72K	47.27K	0
Jan 13, 2011	HICKS KAREN A	SALE	27.24	3.37K	91.76K	0
Jan 12, 2011	HICKS KAREN A	SALE	27.18	11.23K	305.3K	0
Jan 11, 2011	HICKS KAREN A	SALE	27.02	13.83K	373.57K	0

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE131.43K1

SALES00

NET SHARES131.43K1

SHARES HELD1.77M1

% NET SHARES-92.57%0%

Frequently Asked Questions