How many institutions own ARVN stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own ARVN shares is 300, representing 94.19% of the company's common stock.

Who are the major shareholders selling Arvinas, Inc. stock?

RHUMBLINE ADVISERS, in the last quarter, reduced its stake in ARVN by -2.65% restricting it's holding to 99.37 thousand shares of worth nearly $846.65K. HENNION & WALSH ASSET MANAGEMENT, INC. also lessened -15.72% of the ARVN shares from its portfolio, reducing its holding to 51.38 thousand shares of worth $437.78K. GROUP ONE TRADING, L.P. also shunned ARVN shares holding by -74.41% last quarter which brought its holding to 55.03 thousand shares worth $468.86M.

Investors who are buying ARVN stock?

As per its latest 13F filing, SWISS NATIONAL BANK increased its stake in ARVN by 20.43% in the last quarter. The institutional holder raised its holding to 113.2 thousand shares having worth more than $964.46K. BML CAPITAL MANAGEMENT, LLC also added 100% more shares of ARVN to its portfolio, raising its holding to 50 thousand shares of worth $426.00K. MARSHALL WACE, LLP also increased its ARVN shares holding by 42.73% which brought its holding to 237.9 thousand shares worth $2.03M.

ARVN's major insiders: who are they?

The insider with the most stakes in ARVN is SHANNON TIMOTHY M , director at the company. Additionally, ARVN stock is highly held by President and CEO Houston John G and director Ratcliffe Liam among others.

Did an insider recently sell ARVN stock?

Company executives, directors, and other insiders own 6.85% percent of Arvinas, Inc.'s stock. Within the last six months, there have been 1 transaction(s) in which ARVN insiders have sold stock, totaling 230 shares. Insiders that have sold shares include LOOMIS DAVID K, SAIK ANDREW, and CACACE ANGELA M.

Which insider recently purchased ARVN stock?

There have been 1 transaction(s) during the past 6-months in which Arvinas, Inc. insiders have bought stock, totalling 30000 shares

How much of ARVN does insiders own?

Around 107.72K Arvinas, Inc. shares are held by insiders, which represents about 6.85% of ARVN stock.

Who is the insider with the largest stake?

ARVN director, SHANNON TIMOTHY M holds the largest portfolio of the company's shares. ARVN shares owned by SHANNON total nearly 1.65 million.

Which institution holds the most shares in ARVN?

RHUMBLINE ADVISERS is the largest institutional owner in ARVN which holds 99.37 thousand shares worth $846.65K or 0.14% of the total ARVN shares outstanding followed by SWISS NATIONAL BANK with ownership of 113.2 thousand shares representing 0.16% of the ARVN ownership. LEGAL & GENERAL GROUP PLC is the third largest stakeholder with 51.81 thousand shares or 0.07% of the ownership worth more than $441.39K.

Is Arvinas, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the ARVN is concerned, it is a stock which is optionable.

Is there a short position on ARVN's shares?

Number of ARVN shares short is 7.76M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding ARVN shares are there?

As of today, 64.22M shares of ARVN are outstanding.

Is there many float in ARVN stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, ARVN has 56.09M shares in float.

ARVN short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for ARVN is 3.07.

Arvinas (ARVN) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares12.09

Short Percent Of Float12.31

Shares Outstanding64.22M

Shares Float56.09M

Shares Short7.76M

Short Ratio3.07

12.31%

Short % of Float

12.09%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

6.85% Percentage of Shares held by All Insiders

94.19% Percentage of Shares held by All Institutions

101.12% Percentage of Float held by Institutions

300

Number of Institutions Holding Shares

Institutional Ownership

About 94.19% of ARVN shares are held by financial institutions. RHUMBLINE ADVISERS is the top corporate investor, holding 99.37K shares valued at $846.65K. A 0.14% stake in Arvinas, Inc. is owned by the company. SWISS NATIONAL BANK owns 113.2K shares valued at $964.46K, which translates its holding of 0.16% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	RHUMBLINE ADVISERS	0.14%	99.37K	846.65K	-2.7K	-2.65%
Sep 30, 2025	SWISS NATIONAL BANK	0.16%	113.2K	964.46K	19.2K	+20.43%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.07%	51.81K	441.39K	0	0
Sep 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.07%	51.38K	437.78K	-9.58K	-15.72%
Sep 30, 2025	BML CAPITAL MANAGEMENT, LLC	0.07%	50K	426K	50K	+100.00%
Sep 30, 2025	GROUP ONE TRADING, L.P.	0.08%	55.03K	468.86M	-160.05K	-74.41%
Sep 30, 2025	YELIN LAPIDOT HOLDINGS MANAGEMENT LTD.	0.06%	46.67K	397.59K	0	0
Sep 30, 2025	ALLSPRING GLOBAL INVESTMENTS HOLDINGS, LLC	0.06%	42.5K	362.1K	-421	-0.98%
Sep 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.06%	42K	1.87M	0	0
Sep 30, 2025	IKARIAN CAPITAL, LLC	0.31%	226.26K	1.93M	-623.74K	-73.38%
Sep 30, 2025	MARSHALL WACE, LLP	0.33%	237.9K	2.03M	71.22K	+42.73%
Sep 30, 2025	STATE STREET CORP	2.57%	1.87M	15.96M	140.76K	+8.13%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.35%	254.4K	2.17M	-170.39K	-40.11%
Sep 30, 2025	Y-INTERCEPT (HONG KONG) LTD	0.39%	283.54K	2.42M	137.79K	+94.54%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.41%	297K	2.53M	58K	+24.27%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.46%	333.7K	2.84M	97.6K	+41.34%
Sep 30, 2025	BLACKROCK, INC.	9.34%	6.8M	57.96M	-86.51K	-1.26%
Sep 30, 2025	LOGOS GLOBAL MANAGEMENT LP	7.66%	5.58M	47.5M	2.28M	+68.94%
Sep 30, 2025	PFIZER INC	4.75%	3.46M	29.46M	0	0
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.29%	1.67M	14.23M	85.09K	+5.37%
Sep 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	2.04%	1.49M	12.67M	903.34K	+154.81%
Sep 30, 2025	ACADIAN ASSET MANAGEMENT LLC	2.01%	1.46M	12.47M	36.58K	+2.56%
Sep 30, 2025	TANG CAPITAL MANAGEMENT LLC	1.91%	1.39M	11.88M	0	0
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	1.66%	1.21M	10.29M	995.13K	+469.08%
Sep 30, 2025	ARMISTICE CAPITAL, LLC	1.65%	1.2M	10.22M	640K	+114.29%
Sep 30, 2025	OPALEYE MANAGEMENT INC.	1.36%	987.82K	8.42M	-692.18K	-41.20%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.01%	736.56K	6.28M	-89.13K	-10.79%
Sep 30, 2025	MONACO ASSET MANAGEMENT SAM	0.98%	710.94K	6.06M	-190K	-21.09%
Sep 30, 2025	AVIDITY PARTNERS MANAGEMENT LP	0.96%	698.36K	5.95M	455.2K	+187.20%
Sep 30, 2025	RANGELEY CAPITAL, LLC	0.96%	695.4K	5.92M	600	+0.09%
Sep 30, 2025	FEDERATED HERMES, INC.	0.94%	680.89K	5.8M	-6.03K	-0.88%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.92%	669.66K	5.71M	-544.7K	-44.86%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.91%	665.75K	5.67M	-2.37K	-0.35%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.84%	609.77K	5.2M	80.36K	+15.18%
Sep 30, 2025	CAXTON ASSOCIATES LLP	0.83%	604.79K	5.15M	306.72K	+102.91%
Sep 30, 2025	NORTHERN TRUST CORP	0.82%	599.22K	5.11M	38.67K	+6.90%
Sep 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.77%	561.43K	4.78M	-324.41K	-36.62%
Sep 30, 2025	QUANTBOT TECHNOLOGIES LP	0.05%	39.69K	338.13K	39.69K	+100.00%
Sep 30, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.05%	39.4K	335.65K	-10.97K	-21.78%
Sep 30, 2025	SIMPLEX TRADING, LLC	0.05%	38.53K	328K	-70.27K	-64.59%
Sep 30, 2025	SG AMERICAS SECURITIES, LLC	0.05%	38.26K	326K	-14.72K	-27.79%
Sep 30, 2025	LPL FINANCIAL LLC	0.16%	119.74K	1.02M	26.85K	+28.90%
Sep 30, 2025	EDMOND DE ROTHSCHILD HOLDING S.A.	0.18%	130K	1.11M	0	0
Sep 30, 2025	NUVEEN, LLC	0.2%	142.78K	1.22M	0	0
Sep 30, 2025	BARCLAYS PLC	0.23%	169.97K	1.45M	-50.86K	-23.03%
Sep 30, 2025	MACQUARIE GROUP LTD	0.25%	180K	1.53M	0	0
Sep 30, 2025	DEUTSCHE BANK AG\	0.26%	192.54K	1.64M	-29.85K	-13.42%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.28%	205.69K	1.75M	5.76K	+2.88%
Sep 30, 2025	JPMORGAN CHASE & CO	0.3%	214.78K	1.83M	177.46K	+475.52%
Sep 30, 2025	QUADRATURE CAPITAL LTD	0.07%	53.5K	456.08K	17.75K	+49.66%
Sep 30, 2025	VIENNA POWSZECHNE TOWARZYSTWO EMERYTALNE S.A. VIENNA INSURANCE GROUP	0.08%	57.5K	489.9K	0	0
Sep 30, 2025	VANGUARD GROUP INC	11.76%	8.56M	72.94M	-831.93K	-8.86%
Sep 30, 2025	ENTROPY TECHNOLOGIES, LP	0.05%	35.3K	300.71K	2.8K	+8.63%
Sep 30, 2025	NEXTECH INVEST, LTD.	1.93%	1.41M	12M	0	0
Sep 30, 2025	UBS GROUP AG	0.55%	400.14K	3.41M	-621.52K	-60.83%
Sep 30, 2025	MORGAN STANLEY	2.28%	1.66M	14.16M	78.49K	+4.96%
Sep 30, 2025	NEW LEAF VENTURE PARTNERS, L.L.C.	2.18%	1.59M	13.51M	0	0
Sep 30, 2025	NORDEA INVESTMENT MANAGEMENT AB	0.77%	557.74K	4.73M	124.25K	+28.66%
Sep 30, 2025	WASATCH ADVISORS LP	0.7%	506.87K	4.32M	54.44K	+12.03%
Sep 30, 2025	JANE STREET GROUP, LLC	0.64%	463.35K	3.95M	463.35K	+100.00%
Sep 30, 2025	ARBITER PARTNERS CAPITAL MANAGEMENT LLC	0.62%	452.79K	3.86M	452.79K	+100.00%
Sep 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.61%	442.7K	3.77M	60.34K	+15.78%
Sep 30, 2025	HRT FINANCIAL LP	0.55%	396.87K	3.38M	253.92K	+177.63%
Sep 30, 2025	D. E. SHAW & CO., INC.	4.6%	3.35M	28.52M	1.2M	+55.63%
Sep 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	2.22%	1.62M	13.78M	1.62M	+100.00%
Sep 30, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0.26%	187.64K	1.6M	183.59K	+4,533.16%
Sep 30, 2025	ROYAL BANK OF CANADA	0.25%	182.16K	1.55M	119.03K	+188.54%
Sep 30, 2025	ZACKS INVESTMENT MANAGEMENT	0.22%	158.08K	1.35M	67.22K	+73.98%
Sep 30, 2025	VOLEON CAPITAL MANAGEMENT LP	0.21%	152.06K	1.3M	152.06K	+100.00%
Sep 30, 2025	BREVAN HOWARD CAPITAL MANAGEMENT LP	0.19%	135.23K	1.15M	135.23K	+100.00%
Sep 30, 2025	SUSQUEHANNA PORTFOLIO STRATEGIES, LLC	0.38%	273.7K	2.33M	273.7K	+100.00%
Sep 30, 2025	FRANKLIN RESOURCES INC	0.35%	257.78K	2.2M	-3.04K	-1.17%
Sep 30, 2025	ALGERT GLOBAL LLC	0.33%	243.33K	2.07M	-649.62K	-72.75%
Sep 30, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.33%	241.5K	2.06M	241.5K	+100.00%
Sep 30, 2025	INVESCO LTD.	0.33%	238.06K	2.03M	75.13K	+46.11%
Sep 30, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	0.31%	222.48K	1.9M	46.24K	+26.24%
Sep 30, 2025	CAMPBELL & CO INVESTMENT ADVISER LLC	0.31%	223.58K	1.9M	168.74K	+307.75%
Sep 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.31%	223.82K	1.91M	-390.64K	-63.57%
Sep 30, 2025	FOX RUN MANAGEMENT, L.L.C.	0.08%	59.17K	504.16K	59.17K	+100.00%
Sep 30, 2025	QUINN OPPORTUNITY PARTNERS LLC	0.08%	61.26K	521.96K	-10K	-14.03%
Sep 30, 2025	HSBC HOLDINGS PLC	0.09%	62.11K	523.44K	-3.52K	-5.36%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.09%	63.77K	543.35K	-23.19K	-26.67%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.11%	83.67K	712.83K	2.79K	+3.45%
Sep 30, 2025	PLATINUM INVESTMENT MANAGEMENT LTD	0.12%	86.93K	740.64K	86.93K	+100.00%
Sep 30, 2025	FIRST TRUST ADVISORS LP	0.14%	98.26K	837.2K	98.26K	+100.00%
Jun 30, 2025	OPALEYE MANAGEMENT INC.	2.31%	1.68M	12.36M	-295K	-14.94%
Jun 30, 2025	CAXTON ASSOCIATES LLP	0.41%	298.06K	2.19M	298.06K	+100.00%
Jun 30, 2025	RANGELEY CAPITAL, LLC	0.95%	694.8K	5.11M	151.8K	+27.96%
Jun 30, 2025	NEXTECH INVEST, LTD.	1.93%	1.41M	10.37B	0	0
Jun 30, 2025	DEUTSCHE BANK AG\	0.31%	222.4K	1.64M	-6.24K	-2.73%
Jun 30, 2025	GRAHAM CAPITAL MANAGEMENT, L.P.	0.32%	234.63K	1.73M	-66.68K	-22.13%
Jun 30, 2025	CAPTION MANAGEMENT, LLC	0.32%	236.1K	1.74M	-645.4K	-73.22%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.33%	239K	1.76M	239K	+100.00%
Jun 30, 2025	AVIDITY PARTNERS MANAGEMENT LP	0.33%	243.16K	1.79M	-170K	-41.15%
Jun 30, 2025	FRANKLIN RESOURCES INC	0.36%	260.82K	1.92M	196.47K	+305.33%
Jun 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.39%	283.43K	2.09M	208.18K	+276.67%
Jun 30, 2025	VANGUARD GROUP INC	12.9%	9.39M	69.13M	1.03M	+12.33%
Jun 30, 2025	BLACKROCK, INC.	9.46%	6.89M	50.71M	719.85K	+11.67%
Jun 30, 2025	PFIZER INC	4.75%	3.46M	25.45M	0	0
Jun 30, 2025	D. E. SHAW & CO., INC.	2.95%	2.15M	15.83B	2.15M	+100.00%
Jun 30, 2025	MORGAN STANLEY	2.18%	1.58M	11.66B	735.78K	+86.77%
Jun 30, 2025	ALGERT GLOBAL LLC	1.23%	892.94K	6.57M	429.07K	+92.50%
Jun 30, 2025	IKARIAN CAPITAL, LLC	1.17%	850K	6.26M	620.1K	+269.73%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	1.13%	825.69K	6.08B	407.83K	+97.60%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.92%	668.12K	4.92M	-76.01K	-10.21%
Jun 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.84%	614.46K	4.52B	510.88K	+493.24%
Jun 30, 2025	CITADEL ADVISORS LLC	0.35%	256.1K	1.88B	31.3K	+13.92%
Jun 30, 2025	FEDERATED HERMES, INC.	0.94%	686.91K	5.06M	-293.76K	-29.96%
Jun 30, 2025		0.41%	298.06K	2.19M	298.06K	+100.00%
Jun 30, 2025	CENTIVA CAPITAL, LP	0.38%	275.66K	2.03M	-187.81K	-40.52%
Jun 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.53%	382.37K	2.81M	7.34K	+1.96%
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.32%	236.1K	1.74M	-166.3K	-41.33%
Jun 30, 2025	22NW, LP	0.57%	413.53K	3.04M	413.53K	+100.00%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.58%	424.8K	3.13M	-194.59K	-31.42%
Jun 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.29%	212.14K	1.56M	-141.88K	-40.08%
Jun 30, 2025	GROUP ONE TRADING, L.P.	0.3%	215.08K	1.58M	95.43K	+79.76%
Jun 30, 2025	ACADIAN ASSET MANAGEMENT LLC	1.96%	1.43M	10.5M	1.27M	+791.06%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.18%	1.59M	11.67M	48.3K	+3.14%
Jun 30, 2025	NEW LEAF VENTURE PARTNERS, L.L.C.	2.18%	1.59M	11.67M	0	0
Jun 30, 2025	STATE STREET CORP	2.38%	1.73M	12.75M	-163.87K	-8.64%
Jun 30, 2025	LOGOS GLOBAL MANAGEMENT LP	2.06%	1.5M	11.04M	1.5M	+100.00%
Jun 30, 2025	BARCLAYS PLC	0.3%	220.83K	1.63M	80.96K	+57.89%
Jun 30, 2025	VELAN CAPITAL INVESTMENT MANAGEMENT LP	0.69%	500K	3.68M	500K	+100.00%
Jun 30, 2025	MADISON AVENUE PARTNERS, LP	0.69%	500K	3.68M	500K	+100.00%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.73%	529.42K	3.9M	40.18K	+8.21%
Jun 30, 2025	NORDEA INVESTMENT MANAGEMENT AB	0.6%	433.49K	3.36M	199.38K	+85.17%
Jun 30, 2025	WASATCH ADVISORS LP	0.62%	452.42K	3.33M	452.42K	+100.00%
Jun 30, 2025	ARMISTICE CAPITAL, LLC	0.77%	560K	4.12M	560K	+100.00%
Jun 30, 2025	NORTHERN TRUST CORP	0.77%	560.55K	4.13M	-15.49K	-2.69%
Jun 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.8%	583.53K	4.29M	357.16K	+157.77%
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	1.22%	885.84K	6.52M	430.69K	+94.62%
Jun 30, 2025	MONACO ASSET MANAGEMENT SAM	1.24%	900.94K	6.63M	585.48K	+185.60%
Jun 30, 2025	UBS GROUP AG	1.4%	1.02M	7.52M	546.34K	+114.94%
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	1.67%	1.21M	8.94M	1.08M	+817.88%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	1.83%	1.33M	9.82M	-2.49M	-65.13%
Jun 30, 2025	TANG CAPITAL MANAGEMENT LLC	1.91%	1.39M	10.26M	0	0
Mar 31, 2025	CAPTION MANAGEMENT, LLC	0.29%	212.2K	1.49M	65.1K	+44.26%
Mar 31, 2025	MONACO ASSET MANAGEMENT SAM	0.44%	315.46K	2.21M	290.46K	+1,161.84%
Mar 31, 2025	UBS GROUP AG	0.66%	475.31K	3.34M	-1.56M	-76.68%
Mar 31, 2025	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	0.76%	548.1K	3.85M	-1.66M	-75.18%
Mar 31, 2025	FINEPOINT CAPITAL LP	0.96%	694.03K	4.87M	-19.75K	-2.77%
Mar 31, 2025	WOODLINE PARTNERS LP	0.96%	695.95K	4.89M	3.21K	+0.46%
Mar 31, 2025	GRAHAM CAPITAL MANAGEMENT, L.P.	0.42%	301.3K	2.12M	213.43K	+242.86%
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.43%	313.35K	2.2M	313.35K	+100.00%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.54%	388.56K	2.73M	323.35K	+495.87%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.67%	489.24K	3.43M	-46.87K	-8.74%
Mar 31, 2025		0.75%	543K	3.81M	543K	+100.00%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	1.03%	744.12K	5.23M	-99.31K	-11.77%
Mar 31, 2025	MORGAN STANLEY	1.17%	847.95K	5.95M	-152.24K	-15.22%
Mar 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	2.48%	1.8M	12.64M	1.8M	+100.00%
Mar 31, 2025	STATE STREET CORP	2.62%	1.9M	13.31M	259.14K	+15.83%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.85%	619.38K	4.35M	490.63K	+381.05%
Mar 31, 2025	DEUTSCHE BANK AG\	0.32%	228.63K	1.61M	11.41K	+5.25%
Mar 31, 2025	IKARIAN CAPITAL, LLC	0.32%	229.9K	1.61M	229.9K	+100.00%
Mar 31, 2025	PHILOSOPHY CAPITAL MANAGEMENT LLC	1.37%	996.03K	6.99M	996.03K	+100.00%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	1.81%	1.31M	9.2M	995.48K	+316.18%
Mar 31, 2025	BLACKROCK, INC.	8.51%	6.17M	43.31M	-396.54K	-6.04%
Mar 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.31%	226.37K	1.59M	150.17K	+197.08%
Mar 31, 2025	TANG CAPITAL MANAGEMENT LLC	1.92%	1.39M	9.78M	1.39M	+100.00%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.12%	1.54M	10.79M	25.78K	+1.71%
Mar 31, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.63%	455.16K	3.2M	-200.94K	-30.63%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	5.28%	3.83M	26.85M	-277.95K	-6.77%
Mar 31, 2025	OPALEYE MANAGEMENT INC.	2.72%	1.98M	13.86M	350K	+21.54%
Mar 31, 2025	RTW INVESTMENTS, LP	4.6%	3.33M	23.41M	0	0
Mar 31, 2025	PFIZER INC	4.77%	3.46M	24.27M	0	0
Mar 31, 2025	FMR LLC	0.68%	496.49K	3.49M	-1.06M	-68.15%
Mar 31, 2025	FEDERATED HERMES, INC.	1.35%	980.67K	6.88M	933.18K	+1,964.97%
Mar 31, 2025	NORTHERN TRUST CORP	0.79%	576.04K	4.04M	-55.09K	-8.73%
Mar 31, 2025	ALGERT GLOBAL LLC	0.64%	463.87K	3.26M	257.88K	+125.19%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.58%	417.86K	2.93M	-74.98K	-15.21%
Mar 31, 2025	CITADEL ADVISORS LLC	0.31%	224.8K	1.58M	168.5K	+299.29%
Mar 31, 2025	CENTIVA CAPITAL, LP	0.41%	300K	2.11M	300K	+100.00%
Mar 31, 2025	EXOME ASSET MANAGEMENT LLC	0.27%	195.3K	1.37M	-23.41K	-10.70%
Mar 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.49%	354.03K	2.49M	354.03K	+100.00%
Mar 31, 2025	AQUILO CAPITAL MANAGEMENT, LLC	0.5%	360.77K	2.53M	32K	+9.73%
Mar 31, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.52%	375.03K	2.63M	166.04K	+79.45%
Mar 31, 2025	VANGUARD GROUP INC	11.53%	8.36M	58.7M	1.3M	+18.40%
Mar 31, 2025	NORDEA INVESTMENT MANAGEMENT AB	0.32%	234.11K	1.66M	1.22K	+0.52%
Mar 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	1.25%	902.93K	6.34M	469.39K	+108.27%
Mar 31, 2025	JPMORGAN CHASE & CO	0.51%	372.47K	2.61M	-1.48M	-79.94%
Mar 31, 2024	CANDRIAM S.C.A.	0.83%	462.55K	19.09M	-25K	-5.13%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.32%	177.26K	7.32M	-10.04K	-5.36%
Mar 31, 2024	FEDERATED HERMES, INC.	0.31%	171.96K	7.1M	33.94K	+24.59%
Mar 31, 2024	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.31%	170K	7.02M	35.73K	+26.61%
Mar 31, 2024	PANAGORA ASSET MANAGEMENT INC	0.29%	163.09K	6.73M	144.68K	+786.02%
Mar 31, 2024	BNP PARIBAS ARBITRAGE, SNC	0.27%	147.26K	6.08M	-49.8K	-25.27%
Mar 31, 2024	YALE UNIVERSITY	0.26%	143.52K	5.92B	0	0
Mar 31, 2024	FIRST TRUST ADVISORS LP	0.25%	139.31K	5.75M	139.31K	+100.00%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.22%	119.48K	4.93M	30.25K	+33.91%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.21%	114.4K	4.72M	104.2K	+1,021.80%
Mar 31, 2024	SWISS NATIONAL BANK	0.21%	114.1K	4.71M	24.6K	+27.49%
Mar 31, 2024	TREXQUANT INVESTMENT LP	0.18%	102.37K	4.23M	41.13K	+67.16%
Mar 31, 2024	BANQUE PICTET & CIE SA	0.15%	84.92K	3.51M	-8.01K	-8.62%
Mar 31, 2024	L & S ADVISORS INC	0.14%	80.2K	3.31M	80.2K	+100.00%
Mar 31, 2024	WELLS FARGO & COMPANY/MN	0.14%	76.64K	3.16M	17.47K	+29.54%
Mar 31, 2024	VERITION FUND MANAGEMENT LLC	0.14%	75.55K	3.12M	75.55K	+100.00%
Mar 31, 2024	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	0.13%	74K	3.05M	0	0
Mar 31, 2024	RHUMBLINE ADVISERS	0.13%	71.21K	2.94M	2.32K	+3.36%
Mar 31, 2024	HENNION & WALSH ASSET MANAGEMENT, INC.	0.11%	61.86K	2.55M	25.78K	+71.44%
Mar 31, 2024	NOMURA ASSET MANAGEMENT CO LTD	0.11%	60.87K	2.51M	0	0
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.11%	59.6K	2.46M	59.6K	+100.00%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.1%	57.69K	2.38B	10.96K	+23.46%
Mar 31, 2024	STATE OF NEW JERSEY COMMON PENSION FUND D	0.1%	57.15K	2.36M	57.15K	+100.00%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.1%	56.47K	2.33M	3.97K	+7.56%
Mar 31, 2024	NEUBERGER BERMAN GROUP LLC	0.1%	56.37K	2.33M	-384	-0.68%
Mar 31, 2024	STATE OF WISCONSIN INVESTMENT BOARD	0.1%	53.71K	2.22M	2.62K	+5.12%
Mar 31, 2024	YELIN LAPIDOT HOLDINGS MANAGEMENT LTD.	0.09%	49.5K	2.04M	0	0
Mar 31, 2024	SECTORAL ASSET MANAGEMENT INC	0.09%	48.78K	2.01M	-17.22K	-26.09%
Mar 31, 2024	ALGERT GLOBAL LLC	0.09%	48.2K	1.99M	-26.38K	-35.37%
Mar 31, 2024	ALPS ADVISORS INC	0.09%	48.02K	1.98M	12.63K	+35.67%
Mar 31, 2024	ECOR1 CAPITAL, LLC	12.12%	6.73M	277.67M	0	0
Mar 31, 2024	PRICE T ROWE ASSOCIATES INC /MD/	7.87%	4.37M	180.33M	536.3K	+13.99%
Mar 31, 2024	RTW INVESTMENTS, LP	5.94%	3.3M	136.14M	-915.59K	-21.73%
Mar 31, 2024	AVIDITY PARTNERS MANAGEMENT LP	5.38%	2.99M	123.23M	73	0.00%
Mar 31, 2024	PARADIGM BIOCAPITAL ADVISORS LP	4.71%	2.61M	107.94M	1.68M	+180.78%
Mar 31, 2024	BELLEVUE GROUP AG	4.31%	2.39M	98.69M	-116.93K	-4.66%
Mar 31, 2024	CITADEL ADVISORS LLC	4.11%	2.28M	94.14M	-159.37K	-6.53%
Mar 31, 2024	NEXTECH INVEST LTD.	2.54%	1.41M	58.14M	-287.25K	-16.94%
Mar 31, 2024	STATE STREET CORP	2.49%	1.38M	57.06M	195.69K	+16.49%
Mar 31, 2024	COMMODORE CAPITAL LP	2.3%	1.28M	52.63M	275K	+27.50%
Mar 31, 2024	PERCEPTIVE ADVISORS LLC	2.23%	1.24M	51.05M	882.52K	+249.24%
Mar 31, 2024	ARROWMARK COLORADO HOLDINGS LLC	2.17%	1.21M	49.77M	-364.33K	-23.21%
Mar 31, 2024	MORGAN STANLEY	1.22%	675.51K	27.89M	-17.97K	-2.59%
Mar 31, 2024	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.14%	630K	26.01M	-159.49K	-20.20%
Mar 31, 2024	VR ADVISER, LLC	1.13%	627.79K	25.92M	0	0
Mar 31, 2024	BOXER CAPITAL, LLC	1.1%	608.61K	25.12M	0	0
Mar 31, 2024	GOLDMAN SACHS GROUP INC	1.07%	594.4K	24.54M	264.94K	+80.42%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.95%	528.06K	21.8M	58.58K	+12.48%
Mar 31, 2024	NORTHERN TRUST CORP	0.92%	509.13K	21.02M	17.89K	+3.64%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	0.78%	434.3K	17.93M	-57.58K	-11.71%
Mar 31, 2024	WOODLINE PARTNERS LP	0.76%	422.2K	17.43M	34.57K	+8.92%
Mar 31, 2024	RA CAPITAL MANAGEMENT, L.P.	0.76%	421.35K	17.39M	0	0
Mar 31, 2024	AQUILO CAPITAL MANAGEMENT, LLC	0.73%	405.77K	16.75M	-83.39K	-17.05%
Mar 31, 2024	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.68%	379.38K	15.66M	69.71K	+22.51%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.65%	361.97K	14.94M	124.4K	+52.36%
Mar 31, 2024	BROWN ADVISORY INC	0.49%	274.18K	11.32M	8.74K	+3.29%
Mar 31, 2024	FRANKLIN RESOURCES INC	0.48%	268.15K	11.07M	252.94K	+1,662.89%
Mar 31, 2024	CREDIT SUISSE AG/	0.47%	262.22K	10.82M	120.12K	+84.52%
Mar 31, 2024	UBS ASSET MANAGEMENT AMERICAS INC	0.35%	194.5K	8.03M	-38.12K	-16.39%
Mar 31, 2024	AMUNDI	0.35%	193.34K	6.63M	-2.38K	-1.22%
Mar 31, 2024	VANGUARD GROUP INC	11.35%	6.3M	260.05M	1.45M	+29.85%
Mar 31, 2024	BLACKROCK INC.	9.9%	5.49M	226.8M	139.39K	+2.60%
Mar 31, 2024	FMR LLC	4.3%	2.39M	98.62M	144.94K	+6.46%
Mar 31, 2024	JPMORGAN CHASE & CO	3.06%	1.7M	70.17M	-472.99K	-21.77%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	2.37%	1.31M	54.22M	190.69K	+16.99%
Mar 31, 2024	NEW LEAF VENTURE PARTNERS, L.L.C.	2.32%	1.29M	53.23M	0	0
Mar 31, 2024	UBS GROUP AG	0.53%	294.04K	12.14M	37.06K	+14.42%
Mar 31, 2024	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	0.51%	285.33K	11.78M	0	0
Mar 31, 2024	FINEPOINT CAPITAL LP	0.97%	539.1K	22.25M	34.4K	+6.82%
Mar 31, 2024	OPALEYE MANAGEMENT INC.	0.59%	330K	13.62M	66.3K	+25.14%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.59%	325.52K	13.44M	-69.85K	-17.67%
Mar 31, 2024	GILDER GAGNON HOWE & CO LLC	0.59%	324.84K	13.41M	-8.68K	-2.60%
Mar 31, 2024	D. E. SHAW & CO., INC.	0.55%	303.64K	12.53M	218.71K	+257.51%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.53%	296.02K	12.22M	-62.16K	-17.36%
Mar 31, 2024	SCHONFELD STRATEGIC ADVISORS LLC	0.51%	281.1K	11.6M	35.23K	+14.33%
Mar 31, 2024	NORDEA INVESTMENT MANAGEMENT AB	0.5%	276.48K	11.56M	-2.26K	-0.81%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	0.44%	243.67K	10.06M	-115.15K	-32.09%
Mar 31, 2024	WASATCH ADVISORS LP	0.37%	207.43K	8.56M	-15.52K	-6.96%
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.36%	199.35K	8.23M	52.4K	+35.66%
Dec 31, 2023	AQUILO CAPITAL MANAGEMENT, LLC	0.9%	489.15K	20.13M	0	0
Dec 31, 2023	AMUNDI	0.36%	195.72K	7.7M	4.42K	+2.31%
Dec 31, 2023	BNP PARIBAS ARBITRAGE, SNC	0.36%	197.05K	8.11M	97.66K	+98.26%
Dec 31, 2023	WASATCH ADVISORS LP	0.41%	222.94K	9.18M	16.23K	+7.85%
Dec 31, 2023	UBS ASSET MANAGEMENT AMERICAS INC	0.43%	232.62K	9.57M	71.91K	+44.75%
Dec 31, 2023	GREAT POINT PARTNERS LLC	0.43%	234.08K	9.63M	234.08K	+100.00%
Dec 31, 2023	RENAISSANCE TECHNOLOGIES LLC	0.44%	237.57K	9.78M	123.87K	+108.95%
Dec 31, 2023	SCHONFELD STRATEGIC ADVISORS LLC	0.45%	245.87K	10.12M	181.87K	+284.20%
Dec 31, 2023	UBS GROUP AG	0.48%	256.99K	10.58M	-62.75K	-19.63%
Dec 31, 2023	OPALEYE MANAGEMENT INC.	0.49%	263.7K	10.85M	263.7K	+100.00%
Dec 31, 2023	BROWN ADVISORY INC	0.49%	265.43K	10.93M	-170.16K	-39.06%
Dec 31, 2023	NORDEA INVESTMENT MANAGEMENT AB	0.52%	278.74K	11.58M	-6.32K	-2.22%
Dec 31, 2023	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	0.53%	285.33K	11.74M	0	0
Dec 31, 2023	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.57%	309.66K	12.75M	309.66K	+100.00%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.61%	329.46K	13.56M	134.81K	+69.26%
Dec 31, 2023	GILDER GAGNON HOWE & CO LLC	0.62%	333.52K	13.73M	162.67K	+95.21%
Dec 31, 2023	PERCEPTIVE ADVISORS LLC	0.65%	354.08K	14.57M	354.08K	+100.00%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.66%	358.18K	14.74M	20.73K	+6.14%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	0.66%	358.81K	14.77M	-469.31K	-56.67%
Dec 31, 2023	WOODLINE PARTNERS LP	0.72%	387.63K	15.95M	215.03K	+124.58%
Dec 31, 2023	AMERICAN CENTURY COMPANIES INC	0.73%	395.37K	16.27M	-418.1K	-51.40%
Dec 31, 2023	RA CAPITAL MANAGEMENT, L.P.	0.78%	421.35K	17.34M	421.35K	+100.00%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.87%	469.47K	19.32M	39.48K	+9.18%
Dec 31, 2023	CANDRIAM S.C.A.	0.9%	487.56K	20.07M	40K	+8.94%
Dec 31, 2023	NORTHERN TRUST CORP	0.91%	491.24K	20.22M	13.64K	+2.86%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	0.91%	491.88K	20.25M	22.48K	+4.79%
Dec 31, 2023	FINEPOINT CAPITAL LP	0.93%	504.7K	20.77M	0	0
Dec 31, 2023	BOXER CAPITAL, LLC	1.13%	608.61K	25.05M	608.61K	+100.00%
Dec 31, 2023	VR ADVISER, LLC	1.16%	627.79K	25.84M	627.79K	+100.00%
Dec 31, 2023	MORGAN STANLEY	1.28%	693.48K	28.54M	289.16K	+71.52%
Dec 31, 2023	HOLOCENE ADVISORS, LP	1.38%	744.47K	30.64M	744.47K	+100.00%
Dec 31, 2023	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.46%	789.49K	32.5M	789.49K	+100.00%
Dec 31, 2023	NORGES BANK	1.62%	877.71K	36.13M	877.71K	+100.00%
Dec 31, 2023	PARADIGM BIOCAPITAL ADVISORS LP	1.72%	931.3K	38.33M	931.3K	+100.00%
Dec 31, 2023	COMMODORE CAPITAL LP	1.85%	1M	41.16M	1M	+100.00%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	2.08%	1.12M	46.21M	65.24K	+6.17%
Dec 31, 2023	STATE STREET CORP	2.19%	1.19M	48.84M	27.02K	+2.33%
Dec 31, 2023	NEW LEAF VENTURE PARTNERS, L.L.C.	2.38%	1.29M	53.08M	0	0
Dec 31, 2023	ARROWMARK COLORADO HOLDINGS LLC	2.9%	1.57M	64.62M	-517.4K	-24.79%
Dec 31, 2023	NEXTECH INVEST LTD.	3.13%	1.7M	69.79M	1.41M	+490.30%
Dec 31, 2023	JPMORGAN CHASE & CO	4.02%	2.17M	89.43M	183.58K	+9.23%
Dec 31, 2023	FMR LLC	4.15%	2.24M	92.36M	-2.62M	-53.91%
Dec 31, 2023	CITADEL ADVISORS LLC	4.51%	2.44M	99.27M	1.82M	+290.66%
Dec 31, 2023	BELLEVUE GROUP AG	4.64%	2.51M	103.22M	382.53K	+18.00%
Dec 31, 2023	AVIDITY PARTNERS MANAGEMENT LP	5.52%	2.99M	122.87M	370.16K	+14.16%
Dec 31, 2023	PRICE T ROWE ASSOCIATES INC /MD/	7.08%	3.83M	157.73M	1.14M	+42.53%
Dec 31, 2023	RTW INVESTMENTS, LP	7.79%	4.21M	173.43M	4.21M	+100.00%
Dec 31, 2023	VANGUARD GROUP INC	8.97%	4.85M	199.68M	243.17K	+5.28%
Dec 31, 2023	BLACKROCK INC.	9.9%	5.35M	220.41M	385.26K	+7.75%
Dec 31, 2023	ECOR1 CAPITAL, LLC	12.43%	6.73M	276.86M	1.26M	+23.04%
Sep 30, 2023	BLACKROCK INC.	9.31%	4.97M	-	66.14K	+1.35%
Sep 30, 2023	JANE STREET GROUP, LLC	0.09%	50.32K	-	19.02K	+60.78%
Sep 30, 2023	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0.1%	50.95K	-	-5.23K	-9.31%
Sep 30, 2023	ALLIANCEBERNSTEIN L.P.	0.1%	52.5K	-	0	0
Sep 30, 2023	MAN GROUP PLC	0.1%	52.56K	-	1.33K	+2.60%
Sep 30, 2023	CREDIT SUISSE AG/	0.1%	55.26K	-	-395	-0.71%
Sep 30, 2023	AMERIPRISE FINANCIAL INC	0.11%	58.79K	-	4.66K	+8.61%
Sep 30, 2023	WELLS FARGO & COMPANY/MN	0.11%	60.99K	-	-16.74K	-21.53%
Sep 30, 2023	DEUTSCHE BANK AG\	0.12%	63.72K	-	-110.46K	-63.42%
Sep 30, 2023	SCHONFELD STRATEGIC ADVISORS LLC	0.12%	63.99K	-	-1.81K	-2.74%
Sep 30, 2023	PDT PARTNERS, LLC	0.12%	65.12K	-	134	+0.21%
Sep 30, 2023	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.13%	67.32K	-	5.74K	+9.33%
Sep 30, 2023	RHUMBLINE ADVISERS	0.13%	69K	-	278	+0.40%
Sep 30, 2023	RUSSELL INVESTMENTS GROUP, LTD.	0.16%	83.26K	-	38.63K	+86.57%
Sep 30, 2023	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.16%	85K	-	0	0
Sep 30, 2023	TD ASSET MANAGEMENT INC	0.18%	94.87K	-	47.44K	+100.00%
Sep 30, 2023	NEUBERGER BERMAN GROUP LLC	0.18%	95.63K	-	-68.86K	-41.86%
Sep 30, 2023	BNP PARIBAS ARBITRAGE, SNC	0.19%	99.39K	-	36.39K	+57.77%
Sep 30, 2023	SWISS NATIONAL BANK	0.19%	99.7K	-	1.2K	+1.22%
Sep 30, 2023	FEDERATED HERMES, INC.	0.2%	104.26K	-	104.26K	+100.00%
Sep 30, 2023	JACOBS LEVY EQUITY MANAGEMENT, INC	0.22%	120.12K	-	29.24K	+32.18%
Sep 30, 2023	UBS ASSET MANAGEMENT AMERICAS INC	0.3%	160.71K	-	-868	-0.54%
Sep 30, 2023	WOODLINE PARTNERS LP	0.32%	172.6K	-	60K	+53.29%
Sep 30, 2023	ALGERT GLOBAL LLC	0.32%	173.42K	-	54.23K	+45.50%
Sep 30, 2023	ECOR1 CAPITAL, LLC	10.24%	5.47M	-	1.45M	+36.07%
Sep 30, 2023	BANK OF NEW YORK MELLON CORP	0.33%	177.24K	-	-646	-0.36%
Sep 30, 2023	AMUNDI	0.36%	191.3K	-	7.38K	+4.01%
Sep 30, 2023	CUBIST SYSTEMATIC STRATEGIES, LLC	0.36%	191.88K	-	93.8K	+95.63%
Sep 30, 2023	GOLDMAN SACHS GROUP INC	0.36%	194.65K	-	-78.23K	-28.67%
Sep 30, 2023	WASATCH ADVISORS LP	0.39%	206.71K	-	-64.35K	-23.74%
Sep 30, 2023	NORDEA INVESTMENT MANAGEMENT AB	0.53%	285.05K	-	-6.31K	-2.16%
Sep 30, 2023	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	0.53%	285.33K	-	0	0
Sep 30, 2023	NEXTECH INVEST LTD.	0.54%	287.25K	-	0	0
Sep 30, 2023	UBS GROUP AG	0.6%	319.74K	-	-57.78K	-15.30%
Sep 30, 2023	5AM VENTURE MANAGEMENT, LLC	0.6%	320K	-	0	0
Sep 30, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.63%	337.45K	-	91.72K	+37.33%
Sep 30, 2023	MORGAN STANLEY	0.76%	404.32K	-	-47.38K	-10.49%
Sep 30, 2023	BAKER BROS. ADVISORS LP	0.77%	413.48K	-	413.48K	+100.00%
Sep 30, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.81%	429.99K	-	66.43K	+18.27%
Sep 30, 2023	BROWN ADVISORY INC	0.82%	435.59K	-	-5.32K	-1.21%
Sep 30, 2023	CANDRIAM S.C.A.	0.84%	447.55K	-	-20K	-4.28%
Sep 30, 2023	DIMENSIONAL FUND ADVISORS LP	0.88%	469.4K	-	256.69K	+120.68%
Sep 30, 2023	NORTHERN TRUST CORP	0.89%	477.6K	-	14.91K	+3.22%
Sep 30, 2023	FINEPOINT CAPITAL LP	0.95%	504.7K	-	93.2K	+22.65%
Sep 30, 2023	AMERICAN CENTURY COMPANIES INC	1.52%	813.47K	-	-46.51K	-5.41%
Sep 30, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.98%	1.06M	-	62.42K	+6.27%
Sep 30, 2023	NEW LEAF VENTURE PARTNERS, L.L.C.	2.41%	1.29M	-	0	0
Sep 30, 2023	BELLEVUE GROUP AG	3.98%	2.13M	-	-1.8K	-0.08%
Sep 30, 2023	AVIDITY PARTNERS MANAGEMENT LP	4.9%	2.61M	-	-158.23K	-5.71%
Sep 30, 2023	FMR LLC	9.12%	4.87M	-	466.67K	+10.60%

Insiders

Among the ARVN insiders holding of 6.85% of the stake in company, SHANNON TIMOTHY M, director, holds the largest shares of 1.65M. HOUSTON JOHN G, President and CEO, is the second largest ARVN insider with ownership of 1.16M shares. RATCLIFFE LIAM, director, stands third with possession of 185.69K shares of that stake.

Insiders	Designation	Shares Held
SHANNON TIMOTHY M	director	1.65M
HOUSTON JOHN G	President and CEO	1.16M
RATCLIFFE LIAM	director	185.69K
CASSIDY SEAN A	Chief Financial Officer	181.92K
SAIK ANDREW	Chief Financial Officer	164.4K
TAYLOR IAN	President, R&D	159.12K
CACACE ANGELA M	Chief Scientific Officer	154.25K
BERKOWITZ NOAH	Chief Medical Officer	110.02K
MORRISON BRIGGS	director	76.02K
PECK RONALD	Chief Medical Officer	67.52K
LOOMIS DAVID K	Chief Accounting Officer	31.7K
MARGUS BRADLEY ALBERT	director	2K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Nov 07, 2025	LOOMIS DAVID K	SALE	9.89	230	2.27K	31.7K
Sep 22, 2025	MORRISON BRIGGS	PURCHASE	7.57	30K	227.01K	76.02K
Jun 24, 2025	SAIK ANDREW	SALE	7.61	5.7K	43.38K	164.4K
Jun 17, 2025	CACACE ANGELA M	SALE	7.49	2.58K	19.35K	154.25K
Mar 18, 2025	BERKOWITZ NOAH	SALE	8.59	8.66K	74.37K	110.02K
Feb 24, 2025	HOUSTON JOHN G	SALE	16.55	5.15K	85.3K	1.16M
Feb 24, 2025	CACACE ANGELA M	SALE	16.55	1.15K	18.97K	97.23K
Feb 24, 2025	LOOMIS DAVID K	SALE	16.75	1.21K	20.33K	18.86K
Feb 24, 2025	TAYLOR IAN	SALE	16.55	1.66K	27.54K	159.12K
Nov 07, 2024	LOOMIS DAVID K	SALE	27.69	231	6.4K	8.04K
Feb 23, 2024	HOUSTON JOHN G	SALE	47.05	5.2K	244.47K	1.04M
Feb 23, 2024	TAYLOR IAN	SALE	47.05	1.7K	80.03K	147.52K
Feb 23, 2024	CASSIDY SEAN A	SALE	47.05	1.7K	80.08K	181.92K
Feb 23, 2024	PECK RONALD	SALE	47.05	1.7K	79.94K	67.52K
Nov 08, 2023	LOOMIS DAVID K	SALE	17.05	229	3.9K	8.27K
Aug 11, 2023	PECK RONALD	SALE	24.39	1.32K	32.29K	29.97K
Mar 01, 2023	HOUSTON JOHN G	SALE	29.53	5.88K	173.58K	917.43K
Mar 01, 2023	TAYLOR IAN	SALE	29.53	1.05K	31.04K	101.72K
Mar 01, 2023	CASSIDY SEAN A	SALE	29.53	1.75K	51.53K	183.62K
Aug 12, 2022	PECK RONALD	SALE	68.99	1.26K	86.79K	8.15K
Apr 14, 2022	MORRISON BRIGGS	SALE	67.03	10.75K	720.89K	19.98K
Mar 11, 2022	CASSIDY SEAN A	SALE	70.00	15K	1.05M	161.45K
Mar 04, 2022	TAYLOR IAN	SALE	63.94	869	55.56K	83.96K
Mar 04, 2022	HOUSTON JOHN G	SALE	63.94	6.02K	385.17K	843.82K
Mar 04, 2022	CASSIDY SEAN A	SALE	63.94	1.59K	101.86K	161.45K
Feb 15, 2022	TAYLOR IAN	SALE	76.58	100	7.66K	78.65K
Jan 14, 2022	MORRISON BRIGGS	SALE	67.69	2.11K	142.7K	24.75K
Dec 30, 2021	PECK RONALD	SALE	80.96	8.63K	698.6K	5.4K
Dec 17, 2021	CASSIDY SEAN A	SALE	70.00	15K	1.05M	158.25K
Dec 16, 2021	RATCLIFFE LIAM	SALE	68.97	37.21K	2.57M	185.69K
Dec 15, 2021	RATCLIFFE LIAM	SALE	65.74	5.7K	374.37K	271.39K
Dec 14, 2021	RATCLIFFE LIAM	SALE	64.20	700	44.94K	384.93K
Nov 15, 2021	TAYLOR IAN	SALE	84.95	6.48K	550.84K	78.65K
Nov 15, 2021	RATCLIFFE LIAM	SALE	83.90	3.53K	296.35K	541.39K
Nov 12, 2021	RATCLIFFE LIAM	SALE	84.02	12.76K	1.07M	562.68K
Nov 11, 2021	RATCLIFFE LIAM	SALE	85.92	36.21K	3.11M	602.54K
Nov 10, 2021	RATCLIFFE LIAM	SALE	86.59	199	17.23K	662.34K
Nov 09, 2021	RATCLIFFE LIAM	SALE	91.33	580	52.97K	675.7K
Nov 08, 2021	RATCLIFFE LIAM	SALE	92.48	3.69K	341.05K	708.71K
Nov 05, 2021	RATCLIFFE LIAM	SALE	89.65	484	43.39K	0
Nov 01, 2021	HOUSTON JOHN G	SALE	88.86	15.57K	1.38M	832.33K
Sep 07, 2021	SHANNON TIMOTHY M	SALE	90.75	2.03K	184.22K	1.65M
Sep 03, 2021	SHANNON TIMOTHY M	SALE	86.39	2.32K	200.35K	1.69M
Sep 02, 2021	SHANNON TIMOTHY M	SALE	86.34	23.32K	2.01M	1.72M
Sep 01, 2021	SHANNON TIMOTHY M	SALE	88.58	11.86K	1.05M	1.77M
Aug 31, 2021	SHANNON TIMOTHY M	SALE	86.21	12.19K	1.05M	1.85M
Aug 30, 2021	SHANNON TIMOTHY M	SALE	88.22	1.18K	104.19K	1.91M
Aug 27, 2021	SHANNON TIMOTHY M	SALE	86.06	2.37K	204.04K	1.97M
Aug 26, 2021	MARGUS BRADLEY ALBERT	SALE	85.03	9.94K	845.17K	2K
Aug 26, 2021	SHANNON TIMOTHY M	SALE	85.12	11.71K	996.97K	2.02M
Aug 25, 2021	MARGUS BRADLEY ALBERT	SALE	85.00	20K	1.7M	11.94K
Aug 25, 2021	SHANNON TIMOTHY M	SALE	85.03	14.27K	1.21M	2.03M
Aug 24, 2021	SHANNON TIMOTHY M	SALE	87.08	4.64K	403.62K	2.04M
Aug 23, 2021	SHANNON TIMOTHY M	SALE	88.01	1.6K	140.73K	2.05M
Aug 16, 2021	TAYLOR IAN	SALE	86.84	9.24K	802.14K	89.41K
Aug 12, 2021	PECK RONALD	SALE	90.54	1.36K	123.4K	5.4K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE30K1

SALES2301

NET SHARES29.77K0

SHARES HELD107.72K2

% NET SHARES-72.36%-100%

Frequently Asked Questions

Stock Outstanding Shares

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares12.09

Short Percent Of Float12.31

Shares Outstanding64.22M

Shares Float56.09M

Shares Short7.76M

Short Ratio3.07

12.31%

Short % of Float

12.09%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

6.85% Percentage of Shares held by All Insiders

94.19% Percentage of Shares held by All Institutions

101.12% Percentage of Float held by Institutions

300

Number of Institutions Holding Shares

Institutional Ownership

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	RHUMBLINE ADVISERS	0.14%	99.37K	846.65K	-2.7K	-2.65%
Sep 30, 2025	SWISS NATIONAL BANK	0.16%	113.2K	964.46K	19.2K	+20.43%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.07%	51.81K	441.39K	0	0
Sep 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.07%	51.38K	437.78K	-9.58K	-15.72%
Sep 30, 2025	BML CAPITAL MANAGEMENT, LLC	0.07%	50K	426K	50K	+100.00%
Sep 30, 2025	GROUP ONE TRADING, L.P.	0.08%	55.03K	468.86M	-160.05K	-74.41%
Sep 30, 2025	YELIN LAPIDOT HOLDINGS MANAGEMENT LTD.	0.06%	46.67K	397.59K	0	0
Sep 30, 2025	ALLSPRING GLOBAL INVESTMENTS HOLDINGS, LLC	0.06%	42.5K	362.1K	-421	-0.98%
Sep 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.06%	42K	1.87M	0	0
Sep 30, 2025	IKARIAN CAPITAL, LLC	0.31%	226.26K	1.93M	-623.74K	-73.38%
Sep 30, 2025	MARSHALL WACE, LLP	0.33%	237.9K	2.03M	71.22K	+42.73%
Sep 30, 2025	STATE STREET CORP	2.57%	1.87M	15.96M	140.76K	+8.13%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.35%	254.4K	2.17M	-170.39K	-40.11%
Sep 30, 2025	Y-INTERCEPT (HONG KONG) LTD	0.39%	283.54K	2.42M	137.79K	+94.54%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.41%	297K	2.53M	58K	+24.27%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.46%	333.7K	2.84M	97.6K	+41.34%
Sep 30, 2025	BLACKROCK, INC.	9.34%	6.8M	57.96M	-86.51K	-1.26%
Sep 30, 2025	LOGOS GLOBAL MANAGEMENT LP	7.66%	5.58M	47.5M	2.28M	+68.94%
Sep 30, 2025	PFIZER INC	4.75%	3.46M	29.46M	0	0
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.29%	1.67M	14.23M	85.09K	+5.37%
Sep 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	2.04%	1.49M	12.67M	903.34K	+154.81%
Sep 30, 2025	ACADIAN ASSET MANAGEMENT LLC	2.01%	1.46M	12.47M	36.58K	+2.56%
Sep 30, 2025	TANG CAPITAL MANAGEMENT LLC	1.91%	1.39M	11.88M	0	0
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	1.66%	1.21M	10.29M	995.13K	+469.08%
Sep 30, 2025	ARMISTICE CAPITAL, LLC	1.65%	1.2M	10.22M	640K	+114.29%
Sep 30, 2025	OPALEYE MANAGEMENT INC.	1.36%	987.82K	8.42M	-692.18K	-41.20%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.01%	736.56K	6.28M	-89.13K	-10.79%
Sep 30, 2025	MONACO ASSET MANAGEMENT SAM	0.98%	710.94K	6.06M	-190K	-21.09%
Sep 30, 2025	AVIDITY PARTNERS MANAGEMENT LP	0.96%	698.36K	5.95M	455.2K	+187.20%
Sep 30, 2025	RANGELEY CAPITAL, LLC	0.96%	695.4K	5.92M	600	+0.09%
Sep 30, 2025	FEDERATED HERMES, INC.	0.94%	680.89K	5.8M	-6.03K	-0.88%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.92%	669.66K	5.71M	-544.7K	-44.86%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.91%	665.75K	5.67M	-2.37K	-0.35%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.84%	609.77K	5.2M	80.36K	+15.18%
Sep 30, 2025	CAXTON ASSOCIATES LLP	0.83%	604.79K	5.15M	306.72K	+102.91%
Sep 30, 2025	NORTHERN TRUST CORP	0.82%	599.22K	5.11M	38.67K	+6.90%
Sep 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.77%	561.43K	4.78M	-324.41K	-36.62%
Sep 30, 2025	QUANTBOT TECHNOLOGIES LP	0.05%	39.69K	338.13K	39.69K	+100.00%
Sep 30, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.05%	39.4K	335.65K	-10.97K	-21.78%
Sep 30, 2025	SIMPLEX TRADING, LLC	0.05%	38.53K	328K	-70.27K	-64.59%
Sep 30, 2025	SG AMERICAS SECURITIES, LLC	0.05%	38.26K	326K	-14.72K	-27.79%
Sep 30, 2025	LPL FINANCIAL LLC	0.16%	119.74K	1.02M	26.85K	+28.90%
Sep 30, 2025	EDMOND DE ROTHSCHILD HOLDING S.A.	0.18%	130K	1.11M	0	0
Sep 30, 2025	NUVEEN, LLC	0.2%	142.78K	1.22M	0	0
Sep 30, 2025	BARCLAYS PLC	0.23%	169.97K	1.45M	-50.86K	-23.03%
Sep 30, 2025	MACQUARIE GROUP LTD	0.25%	180K	1.53M	0	0
Sep 30, 2025	DEUTSCHE BANK AG\	0.26%	192.54K	1.64M	-29.85K	-13.42%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.28%	205.69K	1.75M	5.76K	+2.88%
Sep 30, 2025	JPMORGAN CHASE & CO	0.3%	214.78K	1.83M	177.46K	+475.52%
Sep 30, 2025	QUADRATURE CAPITAL LTD	0.07%	53.5K	456.08K	17.75K	+49.66%
Sep 30, 2025	VIENNA POWSZECHNE TOWARZYSTWO EMERYTALNE S.A. VIENNA INSURANCE GROUP	0.08%	57.5K	489.9K	0	0
Sep 30, 2025	VANGUARD GROUP INC	11.76%	8.56M	72.94M	-831.93K	-8.86%
Sep 30, 2025	ENTROPY TECHNOLOGIES, LP	0.05%	35.3K	300.71K	2.8K	+8.63%
Sep 30, 2025	NEXTECH INVEST, LTD.	1.93%	1.41M	12M	0	0
Sep 30, 2025	UBS GROUP AG	0.55%	400.14K	3.41M	-621.52K	-60.83%
Sep 30, 2025	MORGAN STANLEY	2.28%	1.66M	14.16M	78.49K	+4.96%
Sep 30, 2025	NEW LEAF VENTURE PARTNERS, L.L.C.	2.18%	1.59M	13.51M	0	0
Sep 30, 2025	NORDEA INVESTMENT MANAGEMENT AB	0.77%	557.74K	4.73M	124.25K	+28.66%
Sep 30, 2025	WASATCH ADVISORS LP	0.7%	506.87K	4.32M	54.44K	+12.03%
Sep 30, 2025	JANE STREET GROUP, LLC	0.64%	463.35K	3.95M	463.35K	+100.00%
Sep 30, 2025	ARBITER PARTNERS CAPITAL MANAGEMENT LLC	0.62%	452.79K	3.86M	452.79K	+100.00%
Sep 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.61%	442.7K	3.77M	60.34K	+15.78%
Sep 30, 2025	HRT FINANCIAL LP	0.55%	396.87K	3.38M	253.92K	+177.63%
Sep 30, 2025	D. E. SHAW & CO., INC.	4.6%	3.35M	28.52M	1.2M	+55.63%
Sep 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	2.22%	1.62M	13.78M	1.62M	+100.00%
Sep 30, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0.26%	187.64K	1.6M	183.59K	+4,533.16%
Sep 30, 2025	ROYAL BANK OF CANADA	0.25%	182.16K	1.55M	119.03K	+188.54%
Sep 30, 2025	ZACKS INVESTMENT MANAGEMENT	0.22%	158.08K	1.35M	67.22K	+73.98%
Sep 30, 2025	VOLEON CAPITAL MANAGEMENT LP	0.21%	152.06K	1.3M	152.06K	+100.00%
Sep 30, 2025	BREVAN HOWARD CAPITAL MANAGEMENT LP	0.19%	135.23K	1.15M	135.23K	+100.00%
Sep 30, 2025	SUSQUEHANNA PORTFOLIO STRATEGIES, LLC	0.38%	273.7K	2.33M	273.7K	+100.00%
Sep 30, 2025	FRANKLIN RESOURCES INC	0.35%	257.78K	2.2M	-3.04K	-1.17%
Sep 30, 2025	ALGERT GLOBAL LLC	0.33%	243.33K	2.07M	-649.62K	-72.75%
Sep 30, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.33%	241.5K	2.06M	241.5K	+100.00%
Sep 30, 2025	INVESCO LTD.	0.33%	238.06K	2.03M	75.13K	+46.11%
Sep 30, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	0.31%	222.48K	1.9M	46.24K	+26.24%
Sep 30, 2025	CAMPBELL & CO INVESTMENT ADVISER LLC	0.31%	223.58K	1.9M	168.74K	+307.75%
Sep 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.31%	223.82K	1.91M	-390.64K	-63.57%
Sep 30, 2025	FOX RUN MANAGEMENT, L.L.C.	0.08%	59.17K	504.16K	59.17K	+100.00%
Sep 30, 2025	QUINN OPPORTUNITY PARTNERS LLC	0.08%	61.26K	521.96K	-10K	-14.03%
Sep 30, 2025	HSBC HOLDINGS PLC	0.09%	62.11K	523.44K	-3.52K	-5.36%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.09%	63.77K	543.35K	-23.19K	-26.67%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.11%	83.67K	712.83K	2.79K	+3.45%
Sep 30, 2025	PLATINUM INVESTMENT MANAGEMENT LTD	0.12%	86.93K	740.64K	86.93K	+100.00%
Sep 30, 2025	FIRST TRUST ADVISORS LP	0.14%	98.26K	837.2K	98.26K	+100.00%
Jun 30, 2025	OPALEYE MANAGEMENT INC.	2.31%	1.68M	12.36M	-295K	-14.94%
Jun 30, 2025	CAXTON ASSOCIATES LLP	0.41%	298.06K	2.19M	298.06K	+100.00%
Jun 30, 2025	RANGELEY CAPITAL, LLC	0.95%	694.8K	5.11M	151.8K	+27.96%
Jun 30, 2025	NEXTECH INVEST, LTD.	1.93%	1.41M	10.37B	0	0
Jun 30, 2025	DEUTSCHE BANK AG\	0.31%	222.4K	1.64M	-6.24K	-2.73%
Jun 30, 2025	GRAHAM CAPITAL MANAGEMENT, L.P.	0.32%	234.63K	1.73M	-66.68K	-22.13%
Jun 30, 2025	CAPTION MANAGEMENT, LLC	0.32%	236.1K	1.74M	-645.4K	-73.22%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.33%	239K	1.76M	239K	+100.00%
Jun 30, 2025	AVIDITY PARTNERS MANAGEMENT LP	0.33%	243.16K	1.79M	-170K	-41.15%
Jun 30, 2025	FRANKLIN RESOURCES INC	0.36%	260.82K	1.92M	196.47K	+305.33%
Jun 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.39%	283.43K	2.09M	208.18K	+276.67%
Jun 30, 2025	VANGUARD GROUP INC	12.9%	9.39M	69.13M	1.03M	+12.33%
Jun 30, 2025	BLACKROCK, INC.	9.46%	6.89M	50.71M	719.85K	+11.67%
Jun 30, 2025	PFIZER INC	4.75%	3.46M	25.45M	0	0
Jun 30, 2025	D. E. SHAW & CO., INC.	2.95%	2.15M	15.83B	2.15M	+100.00%
Jun 30, 2025	MORGAN STANLEY	2.18%	1.58M	11.66B	735.78K	+86.77%
Jun 30, 2025	ALGERT GLOBAL LLC	1.23%	892.94K	6.57M	429.07K	+92.50%
Jun 30, 2025	IKARIAN CAPITAL, LLC	1.17%	850K	6.26M	620.1K	+269.73%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	1.13%	825.69K	6.08B	407.83K	+97.60%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.92%	668.12K	4.92M	-76.01K	-10.21%
Jun 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.84%	614.46K	4.52B	510.88K	+493.24%
Jun 30, 2025	CITADEL ADVISORS LLC	0.35%	256.1K	1.88B	31.3K	+13.92%
Jun 30, 2025	FEDERATED HERMES, INC.	0.94%	686.91K	5.06M	-293.76K	-29.96%
Jun 30, 2025		0.41%	298.06K	2.19M	298.06K	+100.00%
Jun 30, 2025	CENTIVA CAPITAL, LP	0.38%	275.66K	2.03M	-187.81K	-40.52%
Jun 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.53%	382.37K	2.81M	7.34K	+1.96%
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.32%	236.1K	1.74M	-166.3K	-41.33%
Jun 30, 2025	22NW, LP	0.57%	413.53K	3.04M	413.53K	+100.00%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.58%	424.8K	3.13M	-194.59K	-31.42%
Jun 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.29%	212.14K	1.56M	-141.88K	-40.08%
Jun 30, 2025	GROUP ONE TRADING, L.P.	0.3%	215.08K	1.58M	95.43K	+79.76%
Jun 30, 2025	ACADIAN ASSET MANAGEMENT LLC	1.96%	1.43M	10.5M	1.27M	+791.06%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.18%	1.59M	11.67M	48.3K	+3.14%
Jun 30, 2025	NEW LEAF VENTURE PARTNERS, L.L.C.	2.18%	1.59M	11.67M	0	0
Jun 30, 2025	STATE STREET CORP	2.38%	1.73M	12.75M	-163.87K	-8.64%
Jun 30, 2025	LOGOS GLOBAL MANAGEMENT LP	2.06%	1.5M	11.04M	1.5M	+100.00%
Jun 30, 2025	BARCLAYS PLC	0.3%	220.83K	1.63M	80.96K	+57.89%
Jun 30, 2025	VELAN CAPITAL INVESTMENT MANAGEMENT LP	0.69%	500K	3.68M	500K	+100.00%
Jun 30, 2025	MADISON AVENUE PARTNERS, LP	0.69%	500K	3.68M	500K	+100.00%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.73%	529.42K	3.9M	40.18K	+8.21%
Jun 30, 2025	NORDEA INVESTMENT MANAGEMENT AB	0.6%	433.49K	3.36M	199.38K	+85.17%
Jun 30, 2025	WASATCH ADVISORS LP	0.62%	452.42K	3.33M	452.42K	+100.00%
Jun 30, 2025	ARMISTICE CAPITAL, LLC	0.77%	560K	4.12M	560K	+100.00%
Jun 30, 2025	NORTHERN TRUST CORP	0.77%	560.55K	4.13M	-15.49K	-2.69%
Jun 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.8%	583.53K	4.29M	357.16K	+157.77%
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	1.22%	885.84K	6.52M	430.69K	+94.62%
Jun 30, 2025	MONACO ASSET MANAGEMENT SAM	1.24%	900.94K	6.63M	585.48K	+185.60%
Jun 30, 2025	UBS GROUP AG	1.4%	1.02M	7.52M	546.34K	+114.94%
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	1.67%	1.21M	8.94M	1.08M	+817.88%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	1.83%	1.33M	9.82M	-2.49M	-65.13%
Jun 30, 2025	TANG CAPITAL MANAGEMENT LLC	1.91%	1.39M	10.26M	0	0
Mar 31, 2025	CAPTION MANAGEMENT, LLC	0.29%	212.2K	1.49M	65.1K	+44.26%
Mar 31, 2025	MONACO ASSET MANAGEMENT SAM	0.44%	315.46K	2.21M	290.46K	+1,161.84%
Mar 31, 2025	UBS GROUP AG	0.66%	475.31K	3.34M	-1.56M	-76.68%
Mar 31, 2025	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	0.76%	548.1K	3.85M	-1.66M	-75.18%
Mar 31, 2025	FINEPOINT CAPITAL LP	0.96%	694.03K	4.87M	-19.75K	-2.77%
Mar 31, 2025	WOODLINE PARTNERS LP	0.96%	695.95K	4.89M	3.21K	+0.46%
Mar 31, 2025	GRAHAM CAPITAL MANAGEMENT, L.P.	0.42%	301.3K	2.12M	213.43K	+242.86%
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.43%	313.35K	2.2M	313.35K	+100.00%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.54%	388.56K	2.73M	323.35K	+495.87%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.67%	489.24K	3.43M	-46.87K	-8.74%
Mar 31, 2025		0.75%	543K	3.81M	543K	+100.00%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	1.03%	744.12K	5.23M	-99.31K	-11.77%
Mar 31, 2025	MORGAN STANLEY	1.17%	847.95K	5.95M	-152.24K	-15.22%
Mar 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	2.48%	1.8M	12.64M	1.8M	+100.00%
Mar 31, 2025	STATE STREET CORP	2.62%	1.9M	13.31M	259.14K	+15.83%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.85%	619.38K	4.35M	490.63K	+381.05%
Mar 31, 2025	DEUTSCHE BANK AG\	0.32%	228.63K	1.61M	11.41K	+5.25%
Mar 31, 2025	IKARIAN CAPITAL, LLC	0.32%	229.9K	1.61M	229.9K	+100.00%
Mar 31, 2025	PHILOSOPHY CAPITAL MANAGEMENT LLC	1.37%	996.03K	6.99M	996.03K	+100.00%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	1.81%	1.31M	9.2M	995.48K	+316.18%
Mar 31, 2025	BLACKROCK, INC.	8.51%	6.17M	43.31M	-396.54K	-6.04%
Mar 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.31%	226.37K	1.59M	150.17K	+197.08%
Mar 31, 2025	TANG CAPITAL MANAGEMENT LLC	1.92%	1.39M	9.78M	1.39M	+100.00%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.12%	1.54M	10.79M	25.78K	+1.71%
Mar 31, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.63%	455.16K	3.2M	-200.94K	-30.63%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	5.28%	3.83M	26.85M	-277.95K	-6.77%
Mar 31, 2025	OPALEYE MANAGEMENT INC.	2.72%	1.98M	13.86M	350K	+21.54%
Mar 31, 2025	RTW INVESTMENTS, LP	4.6%	3.33M	23.41M	0	0
Mar 31, 2025	PFIZER INC	4.77%	3.46M	24.27M	0	0
Mar 31, 2025	FMR LLC	0.68%	496.49K	3.49M	-1.06M	-68.15%
Mar 31, 2025	FEDERATED HERMES, INC.	1.35%	980.67K	6.88M	933.18K	+1,964.97%
Mar 31, 2025	NORTHERN TRUST CORP	0.79%	576.04K	4.04M	-55.09K	-8.73%
Mar 31, 2025	ALGERT GLOBAL LLC	0.64%	463.87K	3.26M	257.88K	+125.19%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.58%	417.86K	2.93M	-74.98K	-15.21%
Mar 31, 2025	CITADEL ADVISORS LLC	0.31%	224.8K	1.58M	168.5K	+299.29%
Mar 31, 2025	CENTIVA CAPITAL, LP	0.41%	300K	2.11M	300K	+100.00%
Mar 31, 2025	EXOME ASSET MANAGEMENT LLC	0.27%	195.3K	1.37M	-23.41K	-10.70%
Mar 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.49%	354.03K	2.49M	354.03K	+100.00%
Mar 31, 2025	AQUILO CAPITAL MANAGEMENT, LLC	0.5%	360.77K	2.53M	32K	+9.73%
Mar 31, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.52%	375.03K	2.63M	166.04K	+79.45%
Mar 31, 2025	VANGUARD GROUP INC	11.53%	8.36M	58.7M	1.3M	+18.40%
Mar 31, 2025	NORDEA INVESTMENT MANAGEMENT AB	0.32%	234.11K	1.66M	1.22K	+0.52%
Mar 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	1.25%	902.93K	6.34M	469.39K	+108.27%
Mar 31, 2025	JPMORGAN CHASE & CO	0.51%	372.47K	2.61M	-1.48M	-79.94%
Mar 31, 2024	CANDRIAM S.C.A.	0.83%	462.55K	19.09M	-25K	-5.13%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.32%	177.26K	7.32M	-10.04K	-5.36%
Mar 31, 2024	FEDERATED HERMES, INC.	0.31%	171.96K	7.1M	33.94K	+24.59%
Mar 31, 2024	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.31%	170K	7.02M	35.73K	+26.61%
Mar 31, 2024	PANAGORA ASSET MANAGEMENT INC	0.29%	163.09K	6.73M	144.68K	+786.02%
Mar 31, 2024	BNP PARIBAS ARBITRAGE, SNC	0.27%	147.26K	6.08M	-49.8K	-25.27%
Mar 31, 2024	YALE UNIVERSITY	0.26%	143.52K	5.92B	0	0
Mar 31, 2024	FIRST TRUST ADVISORS LP	0.25%	139.31K	5.75M	139.31K	+100.00%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.22%	119.48K	4.93M	30.25K	+33.91%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.21%	114.4K	4.72M	104.2K	+1,021.80%
Mar 31, 2024	SWISS NATIONAL BANK	0.21%	114.1K	4.71M	24.6K	+27.49%
Mar 31, 2024	TREXQUANT INVESTMENT LP	0.18%	102.37K	4.23M	41.13K	+67.16%
Mar 31, 2024	BANQUE PICTET & CIE SA	0.15%	84.92K	3.51M	-8.01K	-8.62%
Mar 31, 2024	L & S ADVISORS INC	0.14%	80.2K	3.31M	80.2K	+100.00%
Mar 31, 2024	WELLS FARGO & COMPANY/MN	0.14%	76.64K	3.16M	17.47K	+29.54%
Mar 31, 2024	VERITION FUND MANAGEMENT LLC	0.14%	75.55K	3.12M	75.55K	+100.00%
Mar 31, 2024	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	0.13%	74K	3.05M	0	0
Mar 31, 2024	RHUMBLINE ADVISERS	0.13%	71.21K	2.94M	2.32K	+3.36%
Mar 31, 2024	HENNION & WALSH ASSET MANAGEMENT, INC.	0.11%	61.86K	2.55M	25.78K	+71.44%
Mar 31, 2024	NOMURA ASSET MANAGEMENT CO LTD	0.11%	60.87K	2.51M	0	0
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.11%	59.6K	2.46M	59.6K	+100.00%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.1%	57.69K	2.38B	10.96K	+23.46%
Mar 31, 2024	STATE OF NEW JERSEY COMMON PENSION FUND D	0.1%	57.15K	2.36M	57.15K	+100.00%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.1%	56.47K	2.33M	3.97K	+7.56%
Mar 31, 2024	NEUBERGER BERMAN GROUP LLC	0.1%	56.37K	2.33M	-384	-0.68%
Mar 31, 2024	STATE OF WISCONSIN INVESTMENT BOARD	0.1%	53.71K	2.22M	2.62K	+5.12%
Mar 31, 2024	YELIN LAPIDOT HOLDINGS MANAGEMENT LTD.	0.09%	49.5K	2.04M	0	0
Mar 31, 2024	SECTORAL ASSET MANAGEMENT INC	0.09%	48.78K	2.01M	-17.22K	-26.09%
Mar 31, 2024	ALGERT GLOBAL LLC	0.09%	48.2K	1.99M	-26.38K	-35.37%
Mar 31, 2024	ALPS ADVISORS INC	0.09%	48.02K	1.98M	12.63K	+35.67%
Mar 31, 2024	ECOR1 CAPITAL, LLC	12.12%	6.73M	277.67M	0	0
Mar 31, 2024	PRICE T ROWE ASSOCIATES INC /MD/	7.87%	4.37M	180.33M	536.3K	+13.99%
Mar 31, 2024	RTW INVESTMENTS, LP	5.94%	3.3M	136.14M	-915.59K	-21.73%
Mar 31, 2024	AVIDITY PARTNERS MANAGEMENT LP	5.38%	2.99M	123.23M	73	0.00%
Mar 31, 2024	PARADIGM BIOCAPITAL ADVISORS LP	4.71%	2.61M	107.94M	1.68M	+180.78%
Mar 31, 2024	BELLEVUE GROUP AG	4.31%	2.39M	98.69M	-116.93K	-4.66%
Mar 31, 2024	CITADEL ADVISORS LLC	4.11%	2.28M	94.14M	-159.37K	-6.53%
Mar 31, 2024	NEXTECH INVEST LTD.	2.54%	1.41M	58.14M	-287.25K	-16.94%
Mar 31, 2024	STATE STREET CORP	2.49%	1.38M	57.06M	195.69K	+16.49%
Mar 31, 2024	COMMODORE CAPITAL LP	2.3%	1.28M	52.63M	275K	+27.50%
Mar 31, 2024	PERCEPTIVE ADVISORS LLC	2.23%	1.24M	51.05M	882.52K	+249.24%
Mar 31, 2024	ARROWMARK COLORADO HOLDINGS LLC	2.17%	1.21M	49.77M	-364.33K	-23.21%
Mar 31, 2024	MORGAN STANLEY	1.22%	675.51K	27.89M	-17.97K	-2.59%
Mar 31, 2024	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.14%	630K	26.01M	-159.49K	-20.20%
Mar 31, 2024	VR ADVISER, LLC	1.13%	627.79K	25.92M	0	0
Mar 31, 2024	BOXER CAPITAL, LLC	1.1%	608.61K	25.12M	0	0
Mar 31, 2024	GOLDMAN SACHS GROUP INC	1.07%	594.4K	24.54M	264.94K	+80.42%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.95%	528.06K	21.8M	58.58K	+12.48%
Mar 31, 2024	NORTHERN TRUST CORP	0.92%	509.13K	21.02M	17.89K	+3.64%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	0.78%	434.3K	17.93M	-57.58K	-11.71%
Mar 31, 2024	WOODLINE PARTNERS LP	0.76%	422.2K	17.43M	34.57K	+8.92%
Mar 31, 2024	RA CAPITAL MANAGEMENT, L.P.	0.76%	421.35K	17.39M	0	0
Mar 31, 2024	AQUILO CAPITAL MANAGEMENT, LLC	0.73%	405.77K	16.75M	-83.39K	-17.05%
Mar 31, 2024	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.68%	379.38K	15.66M	69.71K	+22.51%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.65%	361.97K	14.94M	124.4K	+52.36%
Mar 31, 2024	BROWN ADVISORY INC	0.49%	274.18K	11.32M	8.74K	+3.29%
Mar 31, 2024	FRANKLIN RESOURCES INC	0.48%	268.15K	11.07M	252.94K	+1,662.89%
Mar 31, 2024	CREDIT SUISSE AG/	0.47%	262.22K	10.82M	120.12K	+84.52%
Mar 31, 2024	UBS ASSET MANAGEMENT AMERICAS INC	0.35%	194.5K	8.03M	-38.12K	-16.39%
Mar 31, 2024	AMUNDI	0.35%	193.34K	6.63M	-2.38K	-1.22%
Mar 31, 2024	VANGUARD GROUP INC	11.35%	6.3M	260.05M	1.45M	+29.85%
Mar 31, 2024	BLACKROCK INC.	9.9%	5.49M	226.8M	139.39K	+2.60%
Mar 31, 2024	FMR LLC	4.3%	2.39M	98.62M	144.94K	+6.46%
Mar 31, 2024	JPMORGAN CHASE & CO	3.06%	1.7M	70.17M	-472.99K	-21.77%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	2.37%	1.31M	54.22M	190.69K	+16.99%
Mar 31, 2024	NEW LEAF VENTURE PARTNERS, L.L.C.	2.32%	1.29M	53.23M	0	0
Mar 31, 2024	UBS GROUP AG	0.53%	294.04K	12.14M	37.06K	+14.42%
Mar 31, 2024	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	0.51%	285.33K	11.78M	0	0
Mar 31, 2024	FINEPOINT CAPITAL LP	0.97%	539.1K	22.25M	34.4K	+6.82%
Mar 31, 2024	OPALEYE MANAGEMENT INC.	0.59%	330K	13.62M	66.3K	+25.14%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.59%	325.52K	13.44M	-69.85K	-17.67%
Mar 31, 2024	GILDER GAGNON HOWE & CO LLC	0.59%	324.84K	13.41M	-8.68K	-2.60%
Mar 31, 2024	D. E. SHAW & CO., INC.	0.55%	303.64K	12.53M	218.71K	+257.51%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.53%	296.02K	12.22M	-62.16K	-17.36%
Mar 31, 2024	SCHONFELD STRATEGIC ADVISORS LLC	0.51%	281.1K	11.6M	35.23K	+14.33%
Mar 31, 2024	NORDEA INVESTMENT MANAGEMENT AB	0.5%	276.48K	11.56M	-2.26K	-0.81%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	0.44%	243.67K	10.06M	-115.15K	-32.09%
Mar 31, 2024	WASATCH ADVISORS LP	0.37%	207.43K	8.56M	-15.52K	-6.96%
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.36%	199.35K	8.23M	52.4K	+35.66%
Dec 31, 2023	AQUILO CAPITAL MANAGEMENT, LLC	0.9%	489.15K	20.13M	0	0
Dec 31, 2023	AMUNDI	0.36%	195.72K	7.7M	4.42K	+2.31%
Dec 31, 2023	BNP PARIBAS ARBITRAGE, SNC	0.36%	197.05K	8.11M	97.66K	+98.26%
Dec 31, 2023	WASATCH ADVISORS LP	0.41%	222.94K	9.18M	16.23K	+7.85%
Dec 31, 2023	UBS ASSET MANAGEMENT AMERICAS INC	0.43%	232.62K	9.57M	71.91K	+44.75%
Dec 31, 2023	GREAT POINT PARTNERS LLC	0.43%	234.08K	9.63M	234.08K	+100.00%
Dec 31, 2023	RENAISSANCE TECHNOLOGIES LLC	0.44%	237.57K	9.78M	123.87K	+108.95%
Dec 31, 2023	SCHONFELD STRATEGIC ADVISORS LLC	0.45%	245.87K	10.12M	181.87K	+284.20%
Dec 31, 2023	UBS GROUP AG	0.48%	256.99K	10.58M	-62.75K	-19.63%
Dec 31, 2023	OPALEYE MANAGEMENT INC.	0.49%	263.7K	10.85M	263.7K	+100.00%
Dec 31, 2023	BROWN ADVISORY INC	0.49%	265.43K	10.93M	-170.16K	-39.06%
Dec 31, 2023	NORDEA INVESTMENT MANAGEMENT AB	0.52%	278.74K	11.58M	-6.32K	-2.22%
Dec 31, 2023	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	0.53%	285.33K	11.74M	0	0
Dec 31, 2023	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.57%	309.66K	12.75M	309.66K	+100.00%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.61%	329.46K	13.56M	134.81K	+69.26%
Dec 31, 2023	GILDER GAGNON HOWE & CO LLC	0.62%	333.52K	13.73M	162.67K	+95.21%
Dec 31, 2023	PERCEPTIVE ADVISORS LLC	0.65%	354.08K	14.57M	354.08K	+100.00%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.66%	358.18K	14.74M	20.73K	+6.14%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	0.66%	358.81K	14.77M	-469.31K	-56.67%
Dec 31, 2023	WOODLINE PARTNERS LP	0.72%	387.63K	15.95M	215.03K	+124.58%
Dec 31, 2023	AMERICAN CENTURY COMPANIES INC	0.73%	395.37K	16.27M	-418.1K	-51.40%
Dec 31, 2023	RA CAPITAL MANAGEMENT, L.P.	0.78%	421.35K	17.34M	421.35K	+100.00%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.87%	469.47K	19.32M	39.48K	+9.18%
Dec 31, 2023	CANDRIAM S.C.A.	0.9%	487.56K	20.07M	40K	+8.94%
Dec 31, 2023	NORTHERN TRUST CORP	0.91%	491.24K	20.22M	13.64K	+2.86%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	0.91%	491.88K	20.25M	22.48K	+4.79%
Dec 31, 2023	FINEPOINT CAPITAL LP	0.93%	504.7K	20.77M	0	0
Dec 31, 2023	BOXER CAPITAL, LLC	1.13%	608.61K	25.05M	608.61K	+100.00%
Dec 31, 2023	VR ADVISER, LLC	1.16%	627.79K	25.84M	627.79K	+100.00%
Dec 31, 2023	MORGAN STANLEY	1.28%	693.48K	28.54M	289.16K	+71.52%
Dec 31, 2023	HOLOCENE ADVISORS, LP	1.38%	744.47K	30.64M	744.47K	+100.00%
Dec 31, 2023	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.46%	789.49K	32.5M	789.49K	+100.00%
Dec 31, 2023	NORGES BANK	1.62%	877.71K	36.13M	877.71K	+100.00%
Dec 31, 2023	PARADIGM BIOCAPITAL ADVISORS LP	1.72%	931.3K	38.33M	931.3K	+100.00%
Dec 31, 2023	COMMODORE CAPITAL LP	1.85%	1M	41.16M	1M	+100.00%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	2.08%	1.12M	46.21M	65.24K	+6.17%
Dec 31, 2023	STATE STREET CORP	2.19%	1.19M	48.84M	27.02K	+2.33%
Dec 31, 2023	NEW LEAF VENTURE PARTNERS, L.L.C.	2.38%	1.29M	53.08M	0	0
Dec 31, 2023	ARROWMARK COLORADO HOLDINGS LLC	2.9%	1.57M	64.62M	-517.4K	-24.79%
Dec 31, 2023	NEXTECH INVEST LTD.	3.13%	1.7M	69.79M	1.41M	+490.30%
Dec 31, 2023	JPMORGAN CHASE & CO	4.02%	2.17M	89.43M	183.58K	+9.23%
Dec 31, 2023	FMR LLC	4.15%	2.24M	92.36M	-2.62M	-53.91%
Dec 31, 2023	CITADEL ADVISORS LLC	4.51%	2.44M	99.27M	1.82M	+290.66%
Dec 31, 2023	BELLEVUE GROUP AG	4.64%	2.51M	103.22M	382.53K	+18.00%
Dec 31, 2023	AVIDITY PARTNERS MANAGEMENT LP	5.52%	2.99M	122.87M	370.16K	+14.16%
Dec 31, 2023	PRICE T ROWE ASSOCIATES INC /MD/	7.08%	3.83M	157.73M	1.14M	+42.53%
Dec 31, 2023	RTW INVESTMENTS, LP	7.79%	4.21M	173.43M	4.21M	+100.00%
Dec 31, 2023	VANGUARD GROUP INC	8.97%	4.85M	199.68M	243.17K	+5.28%
Dec 31, 2023	BLACKROCK INC.	9.9%	5.35M	220.41M	385.26K	+7.75%
Dec 31, 2023	ECOR1 CAPITAL, LLC	12.43%	6.73M	276.86M	1.26M	+23.04%
Sep 30, 2023	BLACKROCK INC.	9.31%	4.97M	-	66.14K	+1.35%
Sep 30, 2023	JANE STREET GROUP, LLC	0.09%	50.32K	-	19.02K	+60.78%
Sep 30, 2023	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0.1%	50.95K	-	-5.23K	-9.31%
Sep 30, 2023	ALLIANCEBERNSTEIN L.P.	0.1%	52.5K	-	0	0
Sep 30, 2023	MAN GROUP PLC	0.1%	52.56K	-	1.33K	+2.60%
Sep 30, 2023	CREDIT SUISSE AG/	0.1%	55.26K	-	-395	-0.71%
Sep 30, 2023	AMERIPRISE FINANCIAL INC	0.11%	58.79K	-	4.66K	+8.61%
Sep 30, 2023	WELLS FARGO & COMPANY/MN	0.11%	60.99K	-	-16.74K	-21.53%
Sep 30, 2023	DEUTSCHE BANK AG\	0.12%	63.72K	-	-110.46K	-63.42%
Sep 30, 2023	SCHONFELD STRATEGIC ADVISORS LLC	0.12%	63.99K	-	-1.81K	-2.74%
Sep 30, 2023	PDT PARTNERS, LLC	0.12%	65.12K	-	134	+0.21%
Sep 30, 2023	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.13%	67.32K	-	5.74K	+9.33%
Sep 30, 2023	RHUMBLINE ADVISERS	0.13%	69K	-	278	+0.40%
Sep 30, 2023	RUSSELL INVESTMENTS GROUP, LTD.	0.16%	83.26K	-	38.63K	+86.57%
Sep 30, 2023	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.16%	85K	-	0	0
Sep 30, 2023	TD ASSET MANAGEMENT INC	0.18%	94.87K	-	47.44K	+100.00%
Sep 30, 2023	NEUBERGER BERMAN GROUP LLC	0.18%	95.63K	-	-68.86K	-41.86%
Sep 30, 2023	BNP PARIBAS ARBITRAGE, SNC	0.19%	99.39K	-	36.39K	+57.77%
Sep 30, 2023	SWISS NATIONAL BANK	0.19%	99.7K	-	1.2K	+1.22%
Sep 30, 2023	FEDERATED HERMES, INC.	0.2%	104.26K	-	104.26K	+100.00%
Sep 30, 2023	JACOBS LEVY EQUITY MANAGEMENT, INC	0.22%	120.12K	-	29.24K	+32.18%
Sep 30, 2023	UBS ASSET MANAGEMENT AMERICAS INC	0.3%	160.71K	-	-868	-0.54%
Sep 30, 2023	WOODLINE PARTNERS LP	0.32%	172.6K	-	60K	+53.29%
Sep 30, 2023	ALGERT GLOBAL LLC	0.32%	173.42K	-	54.23K	+45.50%
Sep 30, 2023	ECOR1 CAPITAL, LLC	10.24%	5.47M	-	1.45M	+36.07%
Sep 30, 2023	BANK OF NEW YORK MELLON CORP	0.33%	177.24K	-	-646	-0.36%
Sep 30, 2023	AMUNDI	0.36%	191.3K	-	7.38K	+4.01%
Sep 30, 2023	CUBIST SYSTEMATIC STRATEGIES, LLC	0.36%	191.88K	-	93.8K	+95.63%
Sep 30, 2023	GOLDMAN SACHS GROUP INC	0.36%	194.65K	-	-78.23K	-28.67%
Sep 30, 2023	WASATCH ADVISORS LP	0.39%	206.71K	-	-64.35K	-23.74%
Sep 30, 2023	NORDEA INVESTMENT MANAGEMENT AB	0.53%	285.05K	-	-6.31K	-2.16%
Sep 30, 2023	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	0.53%	285.33K	-	0	0
Sep 30, 2023	NEXTECH INVEST LTD.	0.54%	287.25K	-	0	0
Sep 30, 2023	UBS GROUP AG	0.6%	319.74K	-	-57.78K	-15.30%
Sep 30, 2023	5AM VENTURE MANAGEMENT, LLC	0.6%	320K	-	0	0
Sep 30, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.63%	337.45K	-	91.72K	+37.33%
Sep 30, 2023	MORGAN STANLEY	0.76%	404.32K	-	-47.38K	-10.49%
Sep 30, 2023	BAKER BROS. ADVISORS LP	0.77%	413.48K	-	413.48K	+100.00%
Sep 30, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.81%	429.99K	-	66.43K	+18.27%
Sep 30, 2023	BROWN ADVISORY INC	0.82%	435.59K	-	-5.32K	-1.21%
Sep 30, 2023	CANDRIAM S.C.A.	0.84%	447.55K	-	-20K	-4.28%
Sep 30, 2023	DIMENSIONAL FUND ADVISORS LP	0.88%	469.4K	-	256.69K	+120.68%
Sep 30, 2023	NORTHERN TRUST CORP	0.89%	477.6K	-	14.91K	+3.22%
Sep 30, 2023	FINEPOINT CAPITAL LP	0.95%	504.7K	-	93.2K	+22.65%
Sep 30, 2023	AMERICAN CENTURY COMPANIES INC	1.52%	813.47K	-	-46.51K	-5.41%
Sep 30, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.98%	1.06M	-	62.42K	+6.27%
Sep 30, 2023	NEW LEAF VENTURE PARTNERS, L.L.C.	2.41%	1.29M	-	0	0
Sep 30, 2023	BELLEVUE GROUP AG	3.98%	2.13M	-	-1.8K	-0.08%
Sep 30, 2023	AVIDITY PARTNERS MANAGEMENT LP	4.9%	2.61M	-	-158.23K	-5.71%
Sep 30, 2023	FMR LLC	9.12%	4.87M	-	466.67K	+10.60%

Insiders

Insiders	Designation	Shares Held
SHANNON TIMOTHY M	director	1.65M
HOUSTON JOHN G	President and CEO	1.16M
RATCLIFFE LIAM	director	185.69K
CASSIDY SEAN A	Chief Financial Officer	181.92K
SAIK ANDREW	Chief Financial Officer	164.4K
TAYLOR IAN	President, R&D	159.12K
CACACE ANGELA M	Chief Scientific Officer	154.25K
BERKOWITZ NOAH	Chief Medical Officer	110.02K
MORRISON BRIGGS	director	76.02K
PECK RONALD	Chief Medical Officer	67.52K
LOOMIS DAVID K	Chief Accounting Officer	31.7K
MARGUS BRADLEY ALBERT	director	2K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Nov 07, 2025	LOOMIS DAVID K	SALE	9.89	230	2.27K	31.7K
Sep 22, 2025	MORRISON BRIGGS	PURCHASE	7.57	30K	227.01K	76.02K
Jun 24, 2025	SAIK ANDREW	SALE	7.61	5.7K	43.38K	164.4K
Jun 17, 2025	CACACE ANGELA M	SALE	7.49	2.58K	19.35K	154.25K
Mar 18, 2025	BERKOWITZ NOAH	SALE	8.59	8.66K	74.37K	110.02K
Feb 24, 2025	HOUSTON JOHN G	SALE	16.55	5.15K	85.3K	1.16M
Feb 24, 2025	CACACE ANGELA M	SALE	16.55	1.15K	18.97K	97.23K
Feb 24, 2025	LOOMIS DAVID K	SALE	16.75	1.21K	20.33K	18.86K
Feb 24, 2025	TAYLOR IAN	SALE	16.55	1.66K	27.54K	159.12K
Nov 07, 2024	LOOMIS DAVID K	SALE	27.69	231	6.4K	8.04K
Feb 23, 2024	HOUSTON JOHN G	SALE	47.05	5.2K	244.47K	1.04M
Feb 23, 2024	TAYLOR IAN	SALE	47.05	1.7K	80.03K	147.52K
Feb 23, 2024	CASSIDY SEAN A	SALE	47.05	1.7K	80.08K	181.92K
Feb 23, 2024	PECK RONALD	SALE	47.05	1.7K	79.94K	67.52K
Nov 08, 2023	LOOMIS DAVID K	SALE	17.05	229	3.9K	8.27K
Aug 11, 2023	PECK RONALD	SALE	24.39	1.32K	32.29K	29.97K
Mar 01, 2023	HOUSTON JOHN G	SALE	29.53	5.88K	173.58K	917.43K
Mar 01, 2023	TAYLOR IAN	SALE	29.53	1.05K	31.04K	101.72K
Mar 01, 2023	CASSIDY SEAN A	SALE	29.53	1.75K	51.53K	183.62K
Aug 12, 2022	PECK RONALD	SALE	68.99	1.26K	86.79K	8.15K
Apr 14, 2022	MORRISON BRIGGS	SALE	67.03	10.75K	720.89K	19.98K
Mar 11, 2022	CASSIDY SEAN A	SALE	70.00	15K	1.05M	161.45K
Mar 04, 2022	TAYLOR IAN	SALE	63.94	869	55.56K	83.96K
Mar 04, 2022	HOUSTON JOHN G	SALE	63.94	6.02K	385.17K	843.82K
Mar 04, 2022	CASSIDY SEAN A	SALE	63.94	1.59K	101.86K	161.45K
Feb 15, 2022	TAYLOR IAN	SALE	76.58	100	7.66K	78.65K
Jan 14, 2022	MORRISON BRIGGS	SALE	67.69	2.11K	142.7K	24.75K
Dec 30, 2021	PECK RONALD	SALE	80.96	8.63K	698.6K	5.4K
Dec 17, 2021	CASSIDY SEAN A	SALE	70.00	15K	1.05M	158.25K
Dec 16, 2021	RATCLIFFE LIAM	SALE	68.97	37.21K	2.57M	185.69K
Dec 15, 2021	RATCLIFFE LIAM	SALE	65.74	5.7K	374.37K	271.39K
Dec 14, 2021	RATCLIFFE LIAM	SALE	64.20	700	44.94K	384.93K
Nov 15, 2021	TAYLOR IAN	SALE	84.95	6.48K	550.84K	78.65K
Nov 15, 2021	RATCLIFFE LIAM	SALE	83.90	3.53K	296.35K	541.39K
Nov 12, 2021	RATCLIFFE LIAM	SALE	84.02	12.76K	1.07M	562.68K
Nov 11, 2021	RATCLIFFE LIAM	SALE	85.92	36.21K	3.11M	602.54K
Nov 10, 2021	RATCLIFFE LIAM	SALE	86.59	199	17.23K	662.34K
Nov 09, 2021	RATCLIFFE LIAM	SALE	91.33	580	52.97K	675.7K
Nov 08, 2021	RATCLIFFE LIAM	SALE	92.48	3.69K	341.05K	708.71K
Nov 05, 2021	RATCLIFFE LIAM	SALE	89.65	484	43.39K	0
Nov 01, 2021	HOUSTON JOHN G	SALE	88.86	15.57K	1.38M	832.33K
Sep 07, 2021	SHANNON TIMOTHY M	SALE	90.75	2.03K	184.22K	1.65M
Sep 03, 2021	SHANNON TIMOTHY M	SALE	86.39	2.32K	200.35K	1.69M
Sep 02, 2021	SHANNON TIMOTHY M	SALE	86.34	23.32K	2.01M	1.72M
Sep 01, 2021	SHANNON TIMOTHY M	SALE	88.58	11.86K	1.05M	1.77M
Aug 31, 2021	SHANNON TIMOTHY M	SALE	86.21	12.19K	1.05M	1.85M
Aug 30, 2021	SHANNON TIMOTHY M	SALE	88.22	1.18K	104.19K	1.91M
Aug 27, 2021	SHANNON TIMOTHY M	SALE	86.06	2.37K	204.04K	1.97M
Aug 26, 2021	MARGUS BRADLEY ALBERT	SALE	85.03	9.94K	845.17K	2K
Aug 26, 2021	SHANNON TIMOTHY M	SALE	85.12	11.71K	996.97K	2.02M
Aug 25, 2021	MARGUS BRADLEY ALBERT	SALE	85.00	20K	1.7M	11.94K
Aug 25, 2021	SHANNON TIMOTHY M	SALE	85.03	14.27K	1.21M	2.03M
Aug 24, 2021	SHANNON TIMOTHY M	SALE	87.08	4.64K	403.62K	2.04M
Aug 23, 2021	SHANNON TIMOTHY M	SALE	88.01	1.6K	140.73K	2.05M
Aug 16, 2021	TAYLOR IAN	SALE	86.84	9.24K	802.14K	89.41K
Aug 12, 2021	PECK RONALD	SALE	90.54	1.36K	123.4K	5.4K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE30K1

SALES2301

NET SHARES29.77K0

SHARES HELD107.72K2

% NET SHARES-72.36%-100%

ARVN Stock Ownership Breakdown

Arvinas

Stock Outstanding Shares

Market Insider

Institutional Ownership

Insiders

Buying/Selling by Insiders

Insider Transaction Summary (6 Months)

Frequently Asked Questions

Stock Outstanding Shares

Market Insider

Institutional Ownership

Insiders

Buying/Selling by Insiders

Insider Transaction Summary (6 Months)

Frequently Asked Questions