How many institutions own AMLX stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own AMLX shares is 225, representing 103.68% of the company's common stock.

Who are the major shareholders selling Amylyx Pharmaceuticals, Inc. stock?

CORMORANT ASSET MANAGEMENT, LP, in the last quarter, reduced its stake in AMLX by -12.5% restricting it's holding to 350 thousand shares of worth nearly $4.87M. INTECH INVESTMENT MANAGEMENT LLC also lessened -22.14% of the AMLX shares from its portfolio, reducing its holding to 24.92 thousand shares of worth $346.40K. CITIGROUP INC also shunned AMLX shares holding by -16.43% last quarter which brought its holding to 31.78 thousand shares worth $441.77K.

Investors who are buying AMLX stock?

As per its latest 13F filing, CHARLES SCHWAB INVESTMENT MANAGEMENT INC increased its stake in AMLX by 0.45% in the last quarter. The institutional holder raised its holding to 716.23 thousand shares having worth more than $9.96M. STATE OF NEW JERSEY COMMON PENSION FUND D also added 100% more shares of AMLX to its portfolio, raising its holding to 22.52 thousand shares of worth $313.01K. VANGUARD PERSONALIZED INDEXING MANAGEMENT, LLC also increased its AMLX shares holding by 15.51% which brought its holding to 24.07 thousand shares worth $334.60K.

AMLX's major insiders: who are they?

The insider with the most stakes in AMLX is Morningside Venture Investments Ltd , 10 percent owner at the company. Additionally, AMLX stock is highly held by ALS Invest 1 B.V. and Co-Chief Executive Officer Cohen Joshua B among others.

Did an insider recently sell AMLX stock?

Company executives, directors, and other insiders own 7.62% percent of Amylyx Pharmaceuticals, Inc.'s stock. Within the last six months, there have been 18 transaction(s) in which AMLX insiders have sold stock, totaling 422.89K shares. Insiders that have sold shares include MAZZARIELLO GINA, KLEE JUSTIN B., and COHEN JOSHUA B.

Which insider recently purchased AMLX stock?

There have been 2 transaction(s) during the past 6-months in which Amylyx Pharmaceuticals, Inc. insiders have bought stock, totalling 11900 shares

How much of AMLX does insiders own?

Around 34.96M Amylyx Pharmaceuticals, Inc. shares are held by insiders, which represents about 7.62% of AMLX stock.

Who is the insider with the largest stake?

AMLX 10 percent owner, Morningside Venture Investments Ltd holds the largest portfolio of the company's shares. AMLX shares owned by Morningside total nearly 7 million.

Which institution holds the most shares in AMLX?

NEW YORK STATE COMMON RETIREMENT FUND is the largest institutional owner in AMLX which holds 21.9 thousand shares worth $304.41K or 0.02% of the total AMLX shares outstanding followed by CORMORANT ASSET MANAGEMENT, LP with ownership of 350 thousand shares representing 0.37% of the AMLX ownership. CHARLES SCHWAB INVESTMENT MANAGEMENT INC is the third largest stakeholder with 716.23 thousand shares or 0.76% of the ownership worth more than $9.96M.

Is Amylyx Pharmaceuticals, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the AMLX is concerned, it is a stock which is optionable.

Is there a short position on AMLX's shares?

Number of AMLX shares short is 14.51M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding AMLX shares are there?

As of today, 111.19M shares of AMLX are outstanding.

Is there many float in AMLX stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, AMLX has 83.53M shares in float.

AMLX short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for AMLX is 12.95.

Amylyx Pharmaceuticals (AMLX) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares13.05

Short Percent Of Float16.89

Shares Outstanding111.19M

Shares Float83.53M

Shares Short14.51M

Short Ratio12.95

16.89%

Short % of Float

13.05%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

7.62% Percentage of Shares held by All Insiders

103.68% Percentage of Shares held by All Institutions

112.22% Percentage of Float held by Institutions

225

Number of Institutions Holding Shares

Institutional Ownership

About 103.68% of AMLX shares are held by financial institutions. NEW YORK STATE COMMON RETIREMENT FUND is the top corporate investor, holding 21.9K shares valued at $304.41K. A 0.02% stake in Amylyx Pharmaceuticals, Inc. is owned by the company. CORMORANT ASSET MANAGEMENT, LP owns 350K shares valued at $4.87M, which translates its holding of 0.37% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Mar 31, 2026	NEW YORK STATE COMMON RETIREMENT FUND	0.02%	21.9K	304.41K	0	0
Mar 31, 2026	CORMORANT ASSET MANAGEMENT, LP	0.37%	350K	4.87M	-50K	-12.50%
Mar 31, 2026	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.76%	716.23K	9.96M	3.24K	+0.45%
Mar 31, 2026	STATE OF NEW JERSEY COMMON PENSION FUND D	0.02%	22.52K	313.01K	22.52K	+100.00%
Mar 31, 2026	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.03%	23.75K	330.15K	0	0
Mar 31, 2026	VANGUARD PERSONALIZED INDEXING MANAGEMENT, LLC	0.03%	24.07K	334.6K	3.23K	+15.51%
Mar 31, 2026	INTECH INVESTMENT MANAGEMENT LLC	0.03%	24.92K	346.4K	-7.09K	-22.14%
Mar 31, 2026	INTEGRATED QUANTITATIVE INVESTMENTS LLC	0.03%	27.23K	378.55K	0	0
Mar 31, 2026	CITIGROUP INC	0.03%	31.78K	441.77K	-6.25K	-16.43%
Mar 31, 2026	OPTIMIZE FINANCIAL INC	0.03%	32K	444.81K	32K	+100.00%
Mar 31, 2026	VANGUARD ASSET MANAGEMENT, LTD	0.05%	43.28K	601.63K	43.28K	+100.00%
Mar 31, 2026	VANGUARD GLOBAL ADVISERS, LLC	0.05%	47.85K	665.13K	47.85K	+100.00%
Mar 31, 2026	METLIFE INVESTMENT MANAGEMENT, LLC	0.05%	51.59K	717.06K	1.93K	+3.89%
Mar 31, 2026	EAM INVESTORS, LLC	0.06%	53.26K	740.26K	0	0
Mar 31, 2026	LEGAL & GENERAL GROUP PLC	0.06%	55.77K	775.24K	-16.84K	-23.19%
Mar 31, 2026	RUSSELL INVESTMENTS GROUP, LTD.	0.06%	59.35K	824.91K	-6.09K	-9.31%
Mar 31, 2026	WALLEYE CAPITAL LLC	0.07%	61.71K	857.78K	55.97K	+975.10%
Mar 31, 2026	WELLS FARGO & COMPANY/MN	0.08%	75.08K	1.04M	-71.23K	-48.68%
Mar 31, 2026	SEI INVESTMENTS CO	0.09%	85.28K	1.19M	32.42K	+61.34%
Mar 31, 2026	ALPS ADVISORS INC	0.1%	89.98K	1.25M	-189	-0.21%
Mar 31, 2026	RHUMBLINE ADVISERS	0.11%	108.47K	1.51M	9.19K	+9.26%
Mar 31, 2026	SWISS NATIONAL BANK	0.14%	130.3K	1.81M	-31.4K	-19.42%
Mar 31, 2026	ALPHA WAVE GLOBAL, LP	0.15%	142.34K	1.98M	-175.34K	-55.19%
Mar 31, 2026	UBS ASSET MANAGEMENT AMERICAS INC	0.17%	157.09K	2.18M	58.25K	+58.94%
Mar 31, 2026	JPMORGAN CHASE & CO	0.17%	159.66K	2.04M	93.12K	+139.93%
Mar 31, 2026	GEODE CAPITAL MANAGEMENT, LLC	2.34%	2.21M	30.74M	45.4K	+2.10%
Mar 31, 2026	ALMITAS CAPITAL LLC	2.24%	2.12M	29.5M	0	0
Mar 31, 2026	GREAT POINT PARTNERS LLC	1.85%	1.75M	24.33M	0	0
Mar 31, 2026		1%	944.78K	13.13M	944.78K	+100.00%
Mar 31, 2026	DEUTSCHE BANK AG\	1.34%	1.27M	17.62M	-65.45K	-4.91%
Mar 31, 2026	SIREN, L.L.C.	1.3%	1.23M	17.1M	1.23M	+100.00%
Mar 31, 2026	DIMENSIONAL FUND ADVISORS LP	0.96%	903.19K	12.54M	131.94K	+17.11%
Mar 31, 2026	QUBE RESEARCH & TECHNOLOGIES LTD	0.74%	702.24K	9.76M	289.36K	+70.09%
Mar 31, 2026	UBS GROUP AG	0.34%	324.32K	4.51M	-219K	-40.31%
Mar 31, 2026	HIGHVISTA STRATEGIES LLC	0.37%	352.09K	4.89M	113.27K	+47.43%
Mar 31, 2026	FEDERATED HERMES, INC.	0.38%	363.55K	5.05M	-93.87K	-20.52%
Mar 31, 2026	NORTHERN TRUST CORP	0.82%	779.91K	10.84M	-157.86K	-16.83%
Mar 31, 2026	BOXER CAPITAL MANAGEMENT, LLC	0.85%	800K	11.12M	0	0
Mar 31, 2026	WOODLINE PARTNERS LP	0.89%	845.8K	11.76M	392	+0.05%
Mar 31, 2026	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.92%	868.33K	12.07M	-135.7K	-13.52%
Mar 31, 2026	BARCLAYS PLC	1.03%	971.85K	13.51M	676.68K	+229.24%
Mar 31, 2026	ADAR1 CAPITAL MANAGEMENT, LLC	1.06%	1M	13.91M	110.25K	+12.38%
Mar 31, 2026	BALYASNY ASSET MANAGEMENT L.P.	1.17%	1.11M	15.39M	248.59K	+28.95%
Mar 31, 2026	BANK OF AMERICA CORP /DE/	1.41%	1.33M	18.5M	-5.32K	-0.40%
Mar 31, 2026	LOGOS GLOBAL MANAGEMENT LP	0.74%	700K	9.73M	-250K	-26.32%
Mar 31, 2026	STEMPOINT CAPITAL LP	0.71%	669.69K	9.31M	104.55K	+18.50%
Mar 31, 2026	PARKMAN HEALTHCARE PARTNERS LLC	0.66%	621.46K	8.64M	239.7K	+62.79%
Mar 31, 2026	JUPITER ASSET MANAGEMENT LTD	0.63%	592.65K	8.24M	577.08K	+3,705.41%
Mar 31, 2026	VANGUARD FIDUCIARY TRUST CO	0.62%	586.15K	8.15M	586.15K	+100.00%
Mar 31, 2026	NANTAHALA CAPITAL MANAGEMENT, LLC	0.57%	535.68K	7.45M	-300K	-35.90%
Mar 31, 2026	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.53%	499.76K	6.95M	0	0
Mar 31, 2026	CITADEL ADVISORS LLC	0.44%	411.53K	5.72M	66.56K	+19.30%
Mar 31, 2026	TFG ASSET MANAGEMENT GP LTD	0.34%	317.88K	4.42M	45.05K	+16.51%
Mar 31, 2026	IA GLOBAL ASSET MANAGEMENT INC.	0.32%	304.79K	4.24M	304.79K	+100.00%
Mar 31, 2026	INVESCO LTD.	0.18%	171.62K	2.39M	-4.29K	-2.44%
Mar 31, 2026	ALDEBARAN CAPITAL, LLC	0.21%	197.89K	2.75M	-616	-0.31%
Mar 31, 2026	BLACKROCK, INC.	9.34%	8.83M	122.72M	-225.6K	-2.49%
Mar 31, 2026	GOLDMAN SACHS GROUP INC	2.78%	2.63M	36.5M	12.77K	+0.49%
Mar 31, 2026	DRIEHAUS CAPITAL MANAGEMENT LLC	3.16%	2.99M	41.52M	-122.36K	-3.93%
Mar 31, 2026	FRANKLIN RESOURCES INC	2.39%	2.26M	31.44M	1.06M	+88.45%
Mar 31, 2026	ARIZONA STATE RETIREMENT SYSTEM	0.02%	18.1K	251.58K	-4.82K	-21.01%
Mar 31, 2026	PROSHARE ADVISORS LLC	0.02%	18.15K	252.34K	-2.91K	-13.83%
Mar 31, 2026	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	19.49K	270.88K	1.59K	+8.90%
Mar 31, 2026	HEADLANDS TECHNOLOGIES LLC	0.02%	19.81K	275.42K	-10.73K	-35.13%
Mar 31, 2026	PREMIER PATH WEALTH PARTNERS, LLC	0.02%	20.27K	281.68K	0	0
Mar 31, 2026	VIRTUS INVESTMENT ADVISERS, INC.	0.02%	20.82K	289.33K	508	+2.50%
Mar 31, 2026	NUVEEN, LLC	0.28%	264.9K	3.68M	-19.05K	-6.71%
Mar 31, 2026	FMR LLC	17.59%	16.63M	231.16M	112.12K	+0.68%
Mar 31, 2026	PERCEPTIVE ADVISORS LLC	8.76%	8.28M	115.16M	0	0
Mar 31, 2026	TCG CROSSOVER MANAGEMENT, LLC	6.6%	6.24M	86.79M	0	0
Mar 31, 2026	COMMODORE CAPITAL LP	5.97%	5.65M	78.54M	0	0
Mar 31, 2026	JANUS HENDERSON GROUP PLC	5.27%	4.99M	69.26M	520.2K	+11.65%
Mar 31, 2026	SATURN V CAPITAL MANAGEMENT LLC	4.6%	4.35M	60.46M	-146.6K	-3.26%
Mar 31, 2026	EVENTIDE ASSET MANAGEMENT, LLC	1.6%	1.51M	21.04M	810	+0.05%
Mar 31, 2026	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.27%	253.9K	3.53M	145.6K	+134.44%
Mar 31, 2026	BANK OF NEW YORK MELLON CORP	0.27%	251.1K	3.49M	33.76K	+15.53%
Mar 31, 2026	BNP PARIBAS ARBITRAGE, SNC	0.02%	21.14K	293.85K	-4.06K	-16.11%
Mar 31, 2026	ADAGE CAPITAL PARTNERS GP, L.L.C.	3.77%	3.56M	49.49M	783.71K	+28.22%
Mar 31, 2026	FIRST LIGHT ASSET MANAGEMENT, LLC	3.37%	3.19M	44.35M	-164.89K	-4.91%
Mar 31, 2026	STATE STREET CORP	2.5%	2.36M	32.85M	293.28K	+14.17%
Mar 31, 2026	MORGAN STANLEY	2.3%	2.18M	30.24M	-184.28K	-7.81%
Mar 31, 2026	683 CAPITAL MANAGEMENT, LLC	1.62%	1.53M	21.27M	-120K	-7.27%
Mar 31, 2026	PARSONS CAPITAL MANAGEMENT INC/RI	0.02%	21.65K	300.87K	0	0
Dec 31, 2025	FEDERATED HERMES, INC.	0.49%	457.41K	5.53M	245.03K	+115.38%
Dec 31, 2025	EAM INVESTORS, LLC	0.06%	53.26K	643.33K	-21.86K	-29.10%
Dec 31, 2025	FOX RUN MANAGEMENT, L.L.C.	0.04%	35.41K	427.74K	35.41K	+100.00%
Dec 31, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	32.01K	386.63K	12.51K	+64.18%
Dec 31, 2025	WALLEYE CAPITAL LLC	0.03%	31.6K	381.73K	9.4K	+42.34%
Dec 31, 2025	VERITION FUND MANAGEMENT LLC	0.03%	29.49K	356.2K	-34.41K	-53.85%
Dec 31, 2025	JANUS HENDERSON GROUP PLC	4.78%	4.47M	53.99M	1.93M	+76.08%
Dec 31, 2025	STEMPOINT CAPITAL LP	0.61%	565.14K	6.83M	288.26K	+104.11%
Dec 31, 2025	BOXER CAPITAL MANAGEMENT, LLC	0.86%	800K	9.66M	-100K	-11.11%
Dec 31, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	0.9%	835.68K	10.1M	-100K	-10.69%
Dec 31, 2025	WOODLINE PARTNERS LP	0.91%	845.41K	10.21M	118	+0.01%
Dec 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.92%	858.68K	10.37M	-617.62K	-41.84%
Dec 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.95%	890.36K	10.76M	24.15K	+2.79%
Dec 31, 2025	LOGOS GLOBAL MANAGEMENT LP	1.02%	950K	11.48M	-500K	-34.48%
Dec 31, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	1.08%	1M	12.13M	-102.99K	-9.30%
Dec 31, 2025	FRANKLIN RESOURCES INC	1.29%	1.2M	14.5M	1.2M	+100.00%
Dec 31, 2025	DEUTSCHE BANK AG\	1.43%	1.33M	16.11M	-32.29K	-2.36%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	1.43%	1.34M	16.14M	906.49K	+211.05%
Dec 31, 2025	EVENTIDE ASSET MANAGEMENT, LLC	1.62%	1.51M	18.28M	648	+0.04%
Dec 31, 2025	STATE STREET CORP	2.22%	2.07M	25M	448.62K	+27.67%
Dec 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	2.98%	2.78M	33.55M	-4.04M	-59.26%
Dec 31, 2025	VANGUARD GROUP INC	6.22%	5.8M	70.12M	531.16K	+10.07%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.76%	712.99K	8.61M	67.81K	+10.51%
Dec 31, 2025	MORGAN STANLEY	2.53%	2.36M	28.51M	409.52K	+21.00%
Dec 31, 2025	CITADEL ADVISORS LLC	0.37%	344.97K	4.17M	110.3K	+47.00%
Dec 31, 2025	PATIENT SQUARE CAPITAL LP	0.38%	350K	4.23M	33.69K	+10.65%
Dec 31, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.41%	381.76K	4.61M	-197.41K	-34.09%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.32%	2.17M	26.16M	353.5K	+19.51%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	2.8%	2.61M	31.57M	602.59K	+29.97%
Dec 31, 2025	LEGAL & GENERAL GROUP PLC	0.08%	72.61K	877.15K	5.4K	+8.03%
Dec 31, 2025	SQUAREPOINT OPS LLC	0.08%	76.56K	924.87K	76.56K	+100.00%
Dec 31, 2025	CAMPBELL & CO INVESTMENT ADVISER LLC	0.08%	78.76K	951.46K	54.28K	+221.72%
Dec 31, 2025	ALPS ADVISORS INC	0.1%	90.17K	1.09M	90.17K	+100.00%
Dec 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.11%	98.84K	1.19M	98.84K	+100.00%
Dec 31, 2025	RHUMBLINE ADVISERS	0.11%	99.27K	1.2B	617	+0.63%
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.07%	68.89K	832.22K	68.89K	+100.00%
Dec 31, 2025	BANK OF MONTREAL /CAN/	0.15%	138.53K	1.67M	-5.23K	-3.64%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.16%	146.31K	1.77M	52.62K	+56.16%
Dec 31, 2025	SWISS NATIONAL BANK	0.17%	161.7K	1.95M	161.7K	+100.00%
Dec 31, 2025	XTX TOPCO LTD	0.2%	189.67K	2.29M	189.67K	+100.00%
Dec 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.21%	192.5K	2.33M	172.6K	+867.34%
Dec 31, 2025	ALDEBARAN CAPITAL, LLC	0.21%	198.51K	2.4M	-5.97K	-2.92%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.23%	217.35K	2.63M	34.39K	+18.80%
Dec 31, 2025	ACADIAN ASSET MANAGEMENT LLC	0.27%	254.33K	3.07M	-113K	-30.76%
Dec 31, 2025	JANE STREET GROUP, LLC	0.28%	263.24K	3.18B	263.24K	+100.00%
Dec 31, 2025	TFG ASSET MANAGEMENT GP LTD	0.29%	272.83K	3.3M	14.59K	+5.65%
Dec 31, 2025	NUVEEN, LLC	0.3%	283.95K	3.43M	123.53K	+77.00%
Dec 31, 2025	ZURCHER KANTONALBANK (ZURICH CANTONALBANK)	0.04%	35.88K	433.39K	33.97K	+1,782.32%
Dec 31, 2025	GSA CAPITAL PARTNERS LLP	0.04%	36.76K	444K	-15.35K	-29.46%
Dec 31, 2025	CITIGROUP INC	0.04%	38.03K	459.43K	-51	-0.13%
Dec 31, 2025		0.05%	44.22K	534.21M	44.22K	+100.00%
Dec 31, 2025	MARINER, LLC	0.05%	46.34K	559.86K	-1.69K	-3.51%
Dec 31, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.05%	49.65K	599.82K	6.73K	+15.67%
Dec 31, 2025	SEI INVESTMENTS CO	0.06%	52.86K	638.5K	52.86K	+100.00%
Dec 31, 2025	BARCLAYS PLC	0.32%	295.18K	3.57M	-118.94K	-28.72%
Dec 31, 2025	ALPHA WAVE GLOBAL, LP	0.34%	317.68K	3.84M	-9.63K	-2.94%
Dec 31, 2025	TWO SIGMA ADVISERS, LP	0.35%	328.4K	3.97M	185.4K	+129.65%
Dec 31, 2025	ACUTA CAPITAL PARTNERS, LLC	0.36%	333.26K	4.03M	0	0
Dec 31, 2025	TWO SIGMA INVESTMENTS, LP	0.37%	344.4K	4.16M	245.99K	+249.94%
Dec 31, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.54%	499.76K	6.04M	0	0
Dec 31, 2025	AMERIPRISE FINANCIAL INC	0.54%	502.37K	6.07M	368.86K	+276.28%
Dec 31, 2025	UBS GROUP AG	0.58%	543.32K	6.56M	-861.15K	-61.31%
Dec 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	3.33%	3.11M	37.56M	688.74K	+28.45%
Dec 31, 2025	FIRST LIGHT ASSET MANAGEMENT, LLC	3.6%	3.36M	40.53M	-343	-0.01%
Dec 31, 2025	COMMODORE CAPITAL LP	6.05%	5.65M	68.25M	1.57M	+38.63%
Dec 31, 2025	SATURN V CAPITAL MANAGEMENT LLC	4.82%	4.5M	54.32M	-108.39K	-2.35%
Dec 31, 2025	TCG CROSSOVER MANAGEMENT, LLC	6.69%	6.24M	75.43M	0	0
Dec 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.36%	335K	4.05M	-2.46M	-87.99%
Dec 31, 2025	CORMORANT ASSET MANAGEMENT, LP	0.43%	400K	4.83M	-100K	-20.00%
Dec 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.44%	412.87K	4.99M	245.77K	+147.07%
Dec 31, 2025	NORTHERN TRUST CORP	1%	937.76K	11.33M	115.53K	+14.05%
Dec 31, 2025	683 CAPITAL MANAGEMENT, LLC	1.77%	1.65M	19.93M	-110K	-6.25%
Dec 31, 2025	GREAT POINT PARTNERS LLC	1.88%	1.75M	21.14M	50K	+2.94%
Dec 31, 2025	ALMITAS CAPITAL LLC	2.27%	2.12M	25.64M	0	0
Dec 31, 2025	PERCEPTIVE ADVISORS LLC	8.88%	8.28M	100.08M	-667.48K	-7.46%
Dec 31, 2025	FMR LLC	17.7%	16.52M	199.54M	5.14M	+45.16%
Dec 31, 2025	KENNONDALE CAPITAL MANAGEMENT LLC	0.06%	53.42K	645.35K	-55.19K	-50.81%
Dec 31, 2025	JPMORGAN CHASE & CO	0.07%	66.55K	803.89K	30.7K	+85.66%
Dec 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.83%	771.25K	9.32M	261.47K	+51.29%
Dec 31, 2025	SOFINNOVA INVESTMENTS, INC.	0.56%	527.1K	6.37M	527.1K	+100.00%
Dec 31, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.54%	506.24K	6.12M	-193.76K	-27.68%
Dec 31, 2025	BLACKROCK, INC.	9.7%	9.05M	109.38M	1.91M	+26.80%
Sep 30, 2025	T. ROWE PRICE INVESTMENT MANAGEMENT, INC.	1.34%	1.2M	16.28M	1.2M	+100.00%
Sep 30, 2025	PATIENT SQUARE CAPITAL LP	0.35%	316.31K	4.3M	316.31K	+100.00%
Sep 30, 2025	INVESCO LTD.	0.91%	810.64K	11.02M	223.76K	+38.13%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.72%	645.19K	8.77M	56.77K	+9.65%
Sep 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	2.13%	1.9M	25.82M	1.9M	+100.00%
Sep 30, 2025	MORGAN STANLEY	2.19%	1.95M	26.5M	1.46M	+300.56%
Sep 30, 2025	DEUTSCHE BANK AG\	1.53%	1.37M	18.56M	748.6K	+121.35%
Sep 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	1.05%	935.68K	12.72M	-2M	-68.11%
Sep 30, 2025	PFM HEALTH SCIENCES, LP	0.49%	436.16K	5.93M	-296.1K	-40.44%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.48%	429.52K	5.84M	-22.29K	-4.93%
Sep 30, 2025	TREXQUANT INVESTMENT LP	0.25%	222.88K	3.03M	222.88K	+100.00%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.27%	236.2K	3.21M	-52.42K	-18.16%
Sep 30, 2025	TFG ASSET MANAGEMENT GP LTD	0.29%	258.24K	3.51M	39.49K	+18.05%
Sep 30, 2025	STEMPOINT CAPITAL LP	0.31%	276.88K	3.76M	276.88K	+100.00%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.47%	417.77K	5.68M	-1.09M	-72.37%
Sep 30, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.65%	579.17K	7.87M	-70.83K	-10.90%
Sep 30, 2025	ALLY BRIDGE GROUP (NY) LLC	0.49%	437.39K	5.94M	437.39K	+100.00%
Sep 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	7%	6.24M	84.85M	300K	+5.05%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	7.65%	6.82M	92.64M	-1.98M	-22.54%
Sep 30, 2025	BLACKROCK, INC.	8.01%	7.14M	97.04M	1.63M	+29.59%
Sep 30, 2025	PERCEPTIVE ADVISORS LLC	10.04%	8.95M	121.66M	1.05M	+13.29%
Sep 30, 2025	CORMORANT ASSET MANAGEMENT, LP	0.56%	500K	6.8M	500K	+100.00%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.57%	509.78K	6.94M	136.04K	+36.40%
Sep 30, 2025	JENNISON ASSOCIATES LLC	0.65%	578.66K	7.86M	578.66K	+100.00%
Sep 30, 2025	BRAIDWELL LP	0.69%	612.84K	8.33M	612.84K	+100.00%
Sep 30, 2025	ALMITAS CAPITAL LLC	2.38%	2.12M	28.85M	0	0
Sep 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	2.72%	2.42M	32.9M	1.16M	+91.37%
Sep 30, 2025	JANUS HENDERSON GROUP PLC	2.85%	2.54M	34.45M	2.54M	+100.00%
Sep 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	3.13%	2.79M	37.92M	-1.75M	-38.49%
Sep 30, 2025	FMR LLC	12.77%	11.38M	154.64M	8.33M	+273.33%
Sep 30, 2025	BOXER CAPITAL MANAGEMENT, LLC	1.01%	900K	12.23M	-325K	-26.53%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	1.66%	1.48M	20.06M	1.48M	+100.00%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	2.26%	2.01M	27.32M	712.65K	+54.90%
Sep 30, 2025	ALPHA WAVE GLOBAL, LP	0.37%	327.31K	4.45M	51.47K	+18.66%
Sep 30, 2025	ACUTA CAPITAL PARTNERS, LLC	0.37%	333.26K	4.53M	333.26K	+100.00%
Sep 30, 2025	ACADIAN ASSET MANAGEMENT LLC	0.41%	367.33K	4.99M	-201.75K	-35.45%
Sep 30, 2025	WOODLINE PARTNERS LP	0.95%	845.29K	11.49M	-355K	-29.58%
Sep 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.97%	866.2K	11.77M	-338.9K	-28.12%
Sep 30, 2025	LOGOS GLOBAL MANAGEMENT LP	1.63%	1.45M	19.71M	1.45M	+100.00%
Sep 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	1.7%	1.51M	20.55M	1.51M	+100.00%
Sep 30, 2025	VANGUARD GROUP INC	5.92%	5.27M	71.67M	775.72K	+17.25%
Sep 30, 2025	FIRST LIGHT ASSET MANAGEMENT, LLC	3.76%	3.36M	45.61M	3.36M	+100.00%
Sep 30, 2025	SATURN V CAPITAL MANAGEMENT LLC	5.17%	4.6M	62.58M	1.34M	+41.23%
Sep 30, 2025	BARCLAYS PLC	0.46%	414.11K	5.63M	283.84K	+217.88%
Sep 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.56%	499.76K	6.79M	0	0
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.03%	1.81M	24.63M	119.63K	+7.07%
Sep 30, 2025	683 CAPITAL MANAGEMENT, LLC	1.97%	1.76M	23.92M	-400K	-18.52%
Sep 30, 2025	GREAT POINT PARTNERS LLC	1.91%	1.7M	23.1M	-300K	-15.00%
Sep 30, 2025	STATE STREET CORP	1.82%	1.62M	22.03M	612.35K	+60.69%
Sep 30, 2025	JPMORGAN CHASE & CO	0.04%	35.84K	487.12K	-52.15K	-59.26%
Sep 30, 2025	CITIGROUP INC	0.04%	38.08K	517.55K	6.99K	+22.46%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.05%	40.97K	556.73K	40.97K	+100.00%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.05%	42.93K	583.41K	0	0
Sep 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.05%	47.9K	650.93K	-8.93K	-15.72%
Sep 30, 2025	GSA CAPITAL PARTNERS LLP	0.06%	52.11K	708K	-118.43K	-69.44%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.06%	55.41K	752.97K	49.18K	+789.48%
Sep 30, 2025	READYSTATE ASSET MANAGEMENT LP	0.07%	59.13K	803.6K	59.13K	+100.00%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.08%	67.21K	913.41K	59.81K	+808.02%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.11%	93.69K	1.27M	55.59K	+145.90%
Sep 30, 2025	RHUMBLINE ADVISERS	0.11%	98.66K	1.34M	-1.92K	-1.91%
Sep 30, 2025	KENNONDALE CAPITAL MANAGEMENT LLC	0.12%	108.62K	1.48M	13.45K	+14.13%
Sep 30, 2025	BANK OF MONTREAL /CAN/	0.16%	143.75K	1.95M	240	+0.17%
Sep 30, 2025	NUVEEN, LLC	0.18%	160.42K	2.18M	4.88K	+3.14%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.21%	182.96K	2.49M	32.12K	+21.29%
Sep 30, 2025	ALDEBARAN CAPITAL, LLC	0.23%	204.47K	2.78M	-13.35K	-6.13%
Sep 30, 2025	PROSHARE ADVISORS LLC	0.02%	15.04K	204.37K	-2.51K	-14.32%
Sep 30, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	15.63K	212.41K	-2.27K	-12.70%
Sep 30, 2025	QUANTBOT TECHNOLOGIES LP	0.02%	16.65K	226.31K	16.65K	+100.00%
Sep 30, 2025	ENTRYPOINT CAPITAL, LLC	0.02%	17.17K	233.29K	17.17K	+100.00%
Sep 30, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.02%	19.26K	261.77K	3.27K	+20.45%
Sep 30, 2025	HSBC HOLDINGS PLC	0.02%	19.37K	278.14K	19.37K	+100.00%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.02%	19.49K	264.92K	-16.82K	-46.32%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.02%	19.9K	270.44K	-376.3K	-94.98%
Sep 30, 2025	PREMIER PATH WEALTH PARTNERS, LLC	0.02%	20.27K	275.4K	0	0
Sep 30, 2025	VANGUARD PERSONALIZED INDEXING MANAGEMENT, LLC	0.02%	21.1K	286.77K	-22	-0.10%
Sep 30, 2025	PARSONS CAPITAL MANAGEMENT INC/RI	0.02%	21.65K	294.16K	0	0
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.02%	21.9K	297.62K	0	0
Sep 30, 2025	PERSISTENT ASSET PARTNERS LTD	0.03%	22.91K	311.39K	22.91K	+100.00%
Sep 30, 2025	CAMPBELL & CO INVESTMENT ADVISER LLC	0.03%	24.48K	332.71K	24.48K	+100.00%
Sep 30, 2025	GUGGENHEIM CAPITAL LLC	0.03%	24.9K	338.38K	-10.85K	-30.36%
Sep 30, 2025	QUADRATURE CAPITAL LTD	0.03%	28.29K	384.12K	-1.14K	-3.89%
Sep 30, 2025	MONASHEE INVESTMENT MANAGEMENT LLC	0.03%	30K	407.6K	30K	+100.00%
Sep 30, 2025	FEDERATED HERMES, INC.	0.24%	212.38K	2.89M	8.45K	+4.14%
Sep 30, 2025	UBS GROUP AG	1.58%	1.4M	19.09M	151.13K	+12.06%
Sep 30, 2025	COMMODORE CAPITAL LP	4.57%	4.08M	55.39M	4.08M	+100.00%
Sep 30, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.79%	700K	9.51M	700K	+100.00%
Sep 30, 2025	ORBIMED ADVISORS LLC	0.84%	750.6K	10.2M	437.4K	+139.66%
Sep 30, 2025	NORTHERN TRUST CORP	0.92%	822.24K	11.17M	2.07K	+0.25%
Sep 30, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	1.24%	1.11M	15.04M	-47.48K	-4.11%
Jun 30, 2025	FEDERATED HERMES, INC.	0.23%	203.93K	1.31M	1.15K	+0.56%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	1.46%	1.3M	8.32B	-704.98K	-35.20%
Jun 30, 2025	UBS GROUP AG	1.41%	1.25M	8.03M	-135.08K	-9.73%
Jun 30, 2025	CITADEL ADVISORS LLC	1.39%	1.24M	7.97B	-1.51M	-54.93%
Jun 30, 2025	D. E. SHAW & CO., INC.	0.17%	151.5K	971.13M	-118.5K	-43.89%
Jun 30, 2025	BLACKROCK, INC.	6.18%	5.51M	35.32M	3.12M	+130.80%
Jun 30, 2025	ALMITAS CAPITAL LLC	2.38%	2.12M	13.61M	0	0
Jun 30, 2025	ACADIAN ASSET MANAGEMENT LLC	0.64%	569.08K	3.65M	326.98K	+135.05%
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	0.15%	134.38K	861.38K	27.37K	+25.57%
Jun 30, 2025	ALLOSTERY INVESTMENTS LP	0.13%	120.12K	769.96K	-145.98K	-54.86%
Jun 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.04%	36.32K	232.78K	36.32K	+100.00%
Jun 30, 2025	GRAHAM CAPITAL MANAGEMENT, L.P.	0.04%	34.15K	218.92K	34.15K	+100.00%
Jun 30, 2025	QUADRATURE CAPITAL LTD	0.03%	29.43K	188.35K	16.69K	+130.93%
Jun 30, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.03%	23.32K	149.48K	23.32K	+100.00%
Jun 30, 2025	BROWN ADVISORY INC	0.02%	19.93K	127.75K	0	0
Jun 30, 2025	TUDOR INVESTMENT CORP ET AL	0.01%	12.07K	77.39K	-21.36K	-63.88%
Jun 30, 2025	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0%	3.44K	22.07K	513	+17.51%
Jun 30, 2025	LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA	0%	1.8K	11.56K	0	0
Jun 30, 2025	DUNHILL FINANCIAL, LLC	0%	600	3.85K	0	0
Jun 30, 2025	STERLING CAPITAL MANAGEMENT LLC	0%	552	3.54K	552	+100.00%
Jun 30, 2025	PHYSICIAN WEALTH ADVISORS, INC.	0%	274	1.76K	0	0
Jun 30, 2025	DAIWA SECURITIES GROUP INC.	0%	266	2K	0	0
Jun 30, 2025	HARBOUR INVESTMENTS, INC.	0%	90	577	0	0
Jun 30, 2025	SALEM INVESTMENT COUNSELORS INC	0%	55	353	0	0
Jun 30, 2025	SKOPOS LABS, INC.	0%	42	270	42	+100.00%
Jun 30, 2025	Y-INTERCEPT (HONG KONG) LTD	0.27%	240.38K	1.54M	240.38K	+100.00%
Jun 30, 2025	ALDEBARAN CAPITAL, LLC	0.24%	217.83K	1.4M	-41.43K	-15.98%
Jun 30, 2025	PERCEPTIVE ADVISORS LLC	8.87%	7.9M	50.65M	28.02K	+0.36%
Jun 30, 2025	MAREX GROUP PLC	0.02%	20K	128.2K	20K	+100.00%
Jun 30, 2025	TANG CAPITAL MANAGEMENT LLC	0.11%	100K	641K	0	0
Jun 30, 2025	EAM INVESTORS, LLC	0.11%	99.96K	640.74K	99.96K	+100.00%
Jun 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.06%	56.83K	364.29K	-26.41K	-31.72%
Jun 30, 2025	CANTOR FITZGERALD, L. P.	0.06%	50K	320.5K	-50K	-50.00%
Jun 30, 2025	MARINER, LLC	0.05%	48.67K	311.96K	-2.24K	-4.40%
Jun 30, 2025	JUMP FINANCIAL, LLC	0.05%	47.8K	306.4K	47.8K	+100.00%
Jun 30, 2025	CENTIVA CAPITAL, LP	0.05%	45.46K	291.42K	17.24K	+61.09%
Jun 30, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0.04%	37.99K	243.5K	37.99K	+100.00%
Jun 30, 2025	PARSONS CAPITAL MANAGEMENT INC/RI	0.02%	21.65K	138.75K	0	0
Jun 30, 2025	VANGUARD PERSONALIZED INDEXING MANAGEMENT, LLC	0.02%	21.12K	135.4K	-633	-2.91%
Jun 30, 2025	PREMIER PATH WEALTH PARTNERS, LLC	0.02%	20.27K	129.9K	0	0
Jun 30, 2025	MORGAN STANLEY	0.55%	486.89K	3.12B	12.48K	+2.63%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.03%	30.6K	196.15M	30.6K	+100.00%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	9.87%	8.8M	56.41M	3.1M	+54.45%
Jun 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	6.67%	5.94M	38.1M	0	0
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	5.09%	4.54M	29.08M	3.62M	+394.70%
Jun 30, 2025	VANGUARD GROUP INC	5.05%	4.5M	28.83M	381.52K	+9.27%
Jun 30, 2025	FMR LLC	3.42%	3.05M	19.54M	1.89M	+163.22%
Jun 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	3.29%	2.93M	18.81M	0	0
Jun 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	1.42%	1.26M	8.11M	1.26M	+100.00%
Jun 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	1.35%	1.21M	7.72M	-266.49K	-18.11%
Jun 30, 2025	WOODLINE PARTNERS LP	1.35%	1.2M	7.69M	-409.16K	-25.42%
Jun 30, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	1.3%	1.15M	7.4M	-45.21K	-3.77%
Jun 30, 2025	STATE STREET CORP	1.13%	1.01M	6.47M	747.13K	+285.40%
Jun 30, 2025	NORTHERN TRUST CORP	0.92%	820.16K	5.26M	680.83K	+488.64%
Jun 30, 2025	ABRDN PLC	0.83%	738.66K	4.73M	-1.69M	-69.61%
Jun 30, 2025	PFM HEALTH SCIENCES, LP	0.82%	732.26K	4.69M	-101.88K	-12.21%
Jun 30, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.73%	650K	4.17M	650K	+100.00%
Jun 30, 2025	GSA CAPITAL PARTNERS LLP	0.19%	170.53K	1.09M	147.45K	+638.72%
Jun 30, 2025		0.17%	155.54K	996.99K	155.54K	+100.00%
Jun 30, 2025	683 CAPITAL MANAGEMENT, LLC	2.42%	2.16M	13.85M	-251.4K	-10.43%
Jun 30, 2025	GREAT POINT PARTNERS LLC	2.24%	2M	12.82M	188K	+10.38%
Jun 30, 2025	BANK OF MONTREAL /CAN/	0.16%	143.51K	919.91K	0	0
Jun 30, 2025	BOXER CAPITAL MANAGEMENT, LLC	1.37%	1.23M	7.85M	-525K	-30.00%
Jun 30, 2025	NUVEEN, LLC	0.17%	155.54K	996.99K	155.54K	+100.00%
Jun 30, 2025	SATURN V CAPITAL MANAGEMENT LLC	3.66%	3.26M	20.9M	834.13K	+34.38%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.9%	1.69M	10.85M	886.25K	+109.93%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	1.7%	1.51M	9.69M	-1.57M	-50.94%
Jun 30, 2025	DEUTSCHE BANK AG\	0.69%	616.92K	3.95M	46.06K	+8.07%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.66%	588.41K	3.77M	215.56K	+57.81%
Jun 30, 2025	INVESCO LTD.	0.66%	586.88K	3.76M	541.19K	+1,184.38%
Jun 30, 2025	TWO SIGMA ADVISERS, LP	0.53%	470K	3.01M	-179.8K	-27.67%
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.73%	646.44K	4.14M	529.3K	+451.86%
Jun 30, 2025	TWO SIGMA INVESTMENTS, LP	0.63%	558.85K	3.58M	-203.21K	-26.67%
Jun 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.56%	499.76K	3.2M	156.54K	+45.61%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.51%	451.81K	2.9M	-342.55K	-43.12%
Jun 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.49%	438.03K	2.81M	-504.87K	-53.54%
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.44%	396.2K	2.54M	-118.9K	-23.08%
Jun 30, 2025	JANE STREET GROUP, LLC	0.21%	186.99K	1.2M	-144.2K	-43.54%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.17%	150.84K	966.86K	150.84K	+100.00%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.42%	373.74K	2.4M	250.16K	+202.44%
Jun 30, 2025	ORBIMED ADVISORS LLC	0.35%	313.2K	2.01M	-34.8K	-10.00%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.32%	288.62K	1.85M	-2.06K	-0.71%
Jun 30, 2025	ALPHA WAVE GLOBAL, LP	0.31%	275.84K	1.77M	88.53K	+47.26%
Jun 30, 2025	J. GOLDMAN & CO LP	0.29%	258.6K	1.66M	258.6K	+100.00%
Jun 30, 2025	TFG ASSET MANAGEMENT GP LTD	0.25%	218.75K	1.4M	218.75K	+100.00%
Mar 31, 2025	BANK OF MONTREAL /CAN/	0.17%	143.51K	508.03K	0	0
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	3.6%	3.08M	10.91M	2.49M	+418.62%
Mar 31, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	3.42%	2.93M	10.39M	1.48M	+102.07%
Mar 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.17%	148.56K	525.9K	98.31K	+195.65%
Mar 31, 2025	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.18%	155.7K	551.18K	9.2K	+6.28%
Mar 31, 2025	MORGAN STANLEY	0.55%	474.42K	1.68M	10.2K	+2.20%
Mar 31, 2025	STATE STREET CORP	0.31%	261.78K	926.71K	43.4K	+19.87%
Mar 31, 2025	ALDEBARAN CAPITAL, LLC	0.3%	259.25K	917.76K	-3.5K	-1.33%
Mar 31, 2025	WALLEYE CAPITAL LLC	0.29%	250.89K	888.14K	-267.9K	-51.64%
Mar 31, 2025	MARSHALL WACE, LLP	0.29%	247.28K	875.35K	62.6K	+33.90%
Mar 31, 2025	PFM HEALTH SCIENCES, LP	0.97%	834.14K	2.95M	834.14K	+100.00%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.94%	806.16K	2.85M	238.26K	+41.95%
Mar 31, 2025	CITIGROUP INC	0.54%	463.24K	1.64M	-146.08K	-23.97%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.44%	372.85K	1.32M	73.9K	+24.72%
Mar 31, 2025	ORBIMED ADVISORS LLC	0.41%	348K	1.23M	0	0
Mar 31, 2025	JANE STREET GROUP, LLC	0.39%	331.19K	1.17M	-434.29K	-56.73%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.34%	290.68K	1.03M	80.97K	+38.61%
Mar 31, 2025	ALLOSTERY INVESTMENTS LP	0.31%	266.1K	941.99K	266.1K	+100.00%
Mar 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	1.1%	942.89K	3.34M	162.33K	+20.80%
Mar 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	1.07%	916.97K	3.25M	916.97K	+100.00%
Mar 31, 2025	OMERS ADMINISTRATION CORP	0.2%	169.6K	600.38K	103.6K	+156.97%
Mar 31, 2025	ALPHA WAVE GLOBAL, LP	0.22%	187.31K	663.08K	38.68K	+26.03%
Mar 31, 2025		0.24%	202.74K	717.71K	68.3K	+50.80%
Mar 31, 2025	FEDERATED HERMES, INC.	0.24%	202.79K	717.86K	469	+0.23%
Mar 31, 2025	ACADIAN ASSET MANAGEMENT LLC	0.28%	242.11K	855K	-369.82K	-60.44%
Mar 31, 2025	D. E. SHAW & CO., INC.	0.32%	270.01K	955.82K	-36.74K	-11.98%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.6%	515.1K	1.82M	50.7K	+10.92%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.93%	794.35K	2.81M	-1.63M	-67.26%
Mar 31, 2025	FMR LLC	1.35%	1.16M	4.1M	426.63K	+58.33%
Mar 31, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	1.4%	1.2M	4.25M	-63.66K	-5.04%
Mar 31, 2025	BLACKROCK, INC.	2.79%	2.39M	8.45M	108.48K	+4.76%
Mar 31, 2025	ABRDN PLC	2.84%	2.43M	8.6M	707.55K	+41.07%
Mar 31, 2025	CITADEL ADVISORS LLC	3.22%	2.76M	9.76M	787.07K	+39.94%
Mar 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	6.65%	5.7M	20.17M	5.7M	+100.00%
Mar 31, 2025	DEUTSCHE BANK AG\	0.67%	570.86K	2.02M	0	0
Mar 31, 2025	TWO SIGMA ADVISERS, LP	0.76%	649.8K	2.3M	408.4K	+169.18%
Mar 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.88%	750.41K	2.66M	-73.01K	-8.87%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.89%	762.05K	2.7M	110.54K	+16.97%
Mar 31, 2025	UBS GROUP AG	1.62%	1.39M	4.92M	744.9K	+115.75%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	1.72%	1.47M	5.21M	602.54K	+69.39%
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	1.72%	1.47M	5.21M	1.47M	+100.00%
Mar 31, 2025	WOODLINE PARTNERS LP	1.88%	1.61M	5.7M	1.61M	+100.00%
Mar 31, 2025	GREAT POINT PARTNERS LLC	2.11%	1.81M	6.41M	1.81M	+100.00%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	2.34%	2M	7.09M	143.07K	+7.69%
Mar 31, 2025	683 CAPITAL MANAGEMENT, LLC	2.81%	2.41M	8.54M	481.4K	+24.94%
Mar 31, 2025	SATURN V CAPITAL MANAGEMENT LLC	2.83%	2.43M	8.59M	1.54M	+172.92%
Mar 31, 2025	VANGUARD GROUP INC	4.8%	4.12M	14.57M	1.42M	+52.89%
Mar 31, 2025	TCG CROSSOVER MANAGEMENT, LLC	6.94%	5.94M	21.04M	1.3M	+27.99%
Mar 31, 2025	PERCEPTIVE ADVISORS LLC	9.19%	7.87M	27.88M	1.1M	+16.24%
Mar 31, 2025	NORTHERN TRUST CORP	0.16%	139.33K	493.24K	32.77K	+30.75%
Mar 31, 2024	IKARIAN CAPITAL, LLC	0.49%	331.45K	941.32K	-546.05K	-62.23%
Mar 31, 2024	PERCEPTIVE ADVISORS LLC	0.45%	300K	852K	-1.57M	-83.95%
Mar 31, 2024	SOFINNOVA INVESTMENTS, INC.	0.45%	300K	852K	300K	+100.00%
Mar 31, 2024	BOOTHBAY FUND MANAGEMENT, LLC	0.48%	324.4K	921.3K	-72.1K	-18.18%
Mar 31, 2024	Y-INTERCEPT (HONG KONG) LTD	0.51%	341.52K	969.91K	292.31K	+594.08%
Mar 31, 2024	JPMORGAN CHASE & CO	0.61%	409.76K	1.16M	337.87K	+470.00%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.65%	435.9K	1.24M	48.28K	+12.46%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.37%	246.8K	700.91K	-316.14K	-56.16%
Mar 31, 2024	HUDSON BAY CAPITAL MANAGEMENT LP	0.74%	498K	1.41M	37.4K	+8.12%
Mar 31, 2024	SPHERA FUNDS MANAGEMENT LTD.	0.4%	267.25K	758.99K	83.6K	+45.52%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.41%	275.96K	783.72K	155.63K	+129.34%
Mar 31, 2024	SHERBROOKE PARK ADVISERS LLC	0.44%	299.45K	850.44K	299.45K	+100.00%
Mar 31, 2024	SILVERARC CAPITAL MANAGEMENT, LLC	0.74%	500K	1.42M	500K	+100.00%
Mar 31, 2024	CAPTION MANAGEMENT, LLC	0.78%	522.8K	1.48M	422.8K	+422.80%
Mar 31, 2024	WOODLINE PARTNERS LP	0.78%	523.77K	1.49M	52.97K	+11.25%
Mar 31, 2024	ALYESKA INVESTMENT GROUP, L.P.	1.5%	1.01M	2.86M	1.01M	+100.00%
Mar 31, 2024	ROCK SPRINGS CAPITAL MANAGEMENT LP	1.5%	1.01M	2.87M	476.4K	+89.04%
Mar 31, 2024	JANE STREET GROUP, LLC	1.52%	1.03M	2.92M	-129.55K	-11.20%
Mar 31, 2024	D. E. SHAW & CO., INC.	1.55%	1.04M	2.96M	495.62K	+90.61%
Mar 31, 2024	CITADEL ADVISORS LLC	0.67%	453.8K	1.29M	226.6K	+99.74%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	4.37%	2.94M	8.36M	1.69M	+134.17%
Mar 31, 2024	STATE OF WISCONSIN INVESTMENT BOARD	0.54%	361.72K	1.03M	333.27K	+1,171.25%
Mar 31, 2024	WALLEYE CAPITAL LLC	0.54%	361.87K	1.03M	-220.86K	-37.90%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.56%	378.8K	1.08M	-163.75K	-30.18%
Mar 31, 2024	NORTHERN TRUST CORP	0.63%	425.57K	1.21M	-9.87K	-2.27%
Mar 31, 2024	GRAHAM CAPITAL MANAGEMENT, L.P.	0.78%	524.63K	1.49M	524.63K	+100.00%
Mar 31, 2024	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.78%	526.69K	1.5M	270.08K	+105.25%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	1.05%	704.6K	2M	633.31K	+888.39%
Mar 31, 2024	DEUTSCHE BANK AG\	1.12%	756.17K	2.15M	-96.83K	-11.35%
Mar 31, 2024	TWO SIGMA ADVISERS, LP	1.19%	798.9K	2.27M	798.9K	+100.00%
Mar 31, 2024	CITIGROUP INC	1.36%	914.73K	2.6M	527.06K	+135.96%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	1.4%	944.06K	2.68M	461.46K	+95.62%
Mar 31, 2024	PRICE T ROWE ASSOCIATES INC /MD/	1.44%	970.56K	2.76M	75.78K	+8.47%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	1.58%	1.07M	3.03M	35.53K	+3.45%
Mar 31, 2024	BLACKROCK INC.	6.64%	4.47M	12.71M	472.39K	+11.80%
Mar 31, 2024	FARALLON CAPITAL MANAGEMENT LLC	1.71%	1.15M	3.27M	1.15M	+100.00%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	2.13%	1.43M	4.07M	1.39M	+3,171.38%
Mar 31, 2024	BOXER CAPITAL, LLC	2.23%	1.5M	4.26M	1.5M	+100.00%
Mar 31, 2024	FRANKLIN RESOURCES INC	2.75%	1.86M	5.27M	530.89K	+40.07%
Mar 31, 2024	STATE STREET CORP	3.06%	2.06M	5.85M	618.64K	+42.92%
Mar 31, 2024	MORGAN STANLEY	3.07%	2.07M	5.88M	-759.59K	-26.84%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	3.67%	2.47M	7.02M	198.81K	+8.75%
Mar 31, 2024	VANGUARD GROUP INC	7.93%	5.35M	15.19M	72.57K	+1.38%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.05%	32.85K	93.31M	-6.81K	-17.17%
Mar 31, 2024	CREDIT SUISSE AG/	0.05%	36.64K	104.07K	-1.41K	-3.70%
Mar 31, 2024	BELVEDERE TRADING LLC	0.06%	38.4K	109.06K	36.3K	+1,728.57%
Mar 31, 2024	LEGACY ADVISORS, LLC	0.07%	50K	142K	0	0
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.08%	51.54K	146.38K	0	0
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	0.08%	53.2K	151.09K	34.88K	+190.40%
Mar 31, 2024	PROFUND ADVISORS LLC	0.1%	64.97K	184.51M	40.36K	+164.03%
Mar 31, 2024	RHUMBLINE ADVISERS	0.1%	69.4K	197.09K	1.12K	+1.64%
Mar 31, 2024	MACKENZIE FINANCIAL CORP	0.11%	72.57K	206.1K	72.57K	+100.00%
Mar 31, 2024	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	0.11%	73.13K	207.69K	0	0
Mar 31, 2024	VERITION FUND MANAGEMENT LLC	0.11%	75K	213K	75K	+100.00%
Mar 31, 2024	GSA CAPITAL PARTNERS LLP	0.12%	79.65K	226K	-52.53K	-39.74%
Mar 31, 2024	CAPSTONE INVESTMENT ADVISORS, LLC	0.12%	80.08K	227.44K	60.08K	+300.42%
Mar 31, 2024	SIMPLEX TRADING, LLC	0.12%	82.11K	233K	-47.32K	-36.56%
Mar 31, 2024	PHOCAS FINANCIAL CORP.	0.13%	86.07K	1.27K	0	0
Mar 31, 2024	SWISS NATIONAL BANK	0.13%	86.6K	245.94K	6.9K	+8.66%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.14%	95.57K	271.42K	9.92K	+11.58%
Mar 31, 2024	HENNION & WALSH ASSET MANAGEMENT, INC.	0.17%	112.87K	320.54K	27.94K	+32.89%
Mar 31, 2024	ABRDN PLC	0.18%	118.25K	335.82K	-77.25K	-39.51%
Mar 31, 2024	WINTON GROUP LTD	0.18%	119.68K	339.88K	119.68K	+100.00%
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.19%	131.2K	372.61M	16.2K	+14.09%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.2%	137.97K	391.84K	-883.68K	-86.50%
Mar 31, 2024	ALPS ADVISORS INC	0.21%	139.25K	395.47K	89.52K	+180.02%
Mar 31, 2024	AVIVA PLC	0.22%	145.42K	412.99K	145.42K	+100.00%
Mar 31, 2024	FIRST TRUST ADVISORS LP	0.25%	170.48K	484.16K	153.1K	+880.89%
Mar 31, 2024	FEDERATED HERMES, INC.	0.26%	175.98K	499.79K	73.48K	+71.69%
Mar 31, 2024	PANAGORA ASSET MANAGEMENT INC	0.28%	189.02K	536.81K	189.02K	+100.00%
Mar 31, 2024	HAP TRADING, LLC	0.07%	50K	36.25K	50K	+100.00%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.29%	198.03K	562.4K	7.03K	+3.68%
Mar 31, 2024	UBS GROUP AG	0.31%	210.57K	598.03K	171.56K	+439.74%
Mar 31, 2024	GROUP ONE TRADING, L.P.	0.33%	222.72K	632.53K	-280.95K	-55.78%
Dec 31, 2023	GMT CAPITAL CORP	1.17%	786K	11.57M	209.7K	+36.39%
Dec 31, 2023	CITADEL ADVISORS LLC	0.34%	227.2K	3.34M	112.9K	+98.78%
Dec 31, 2023	POLAR ASSET MANAGEMENT PARTNERS INC.	0.36%	242.3K	3.57M	210.3K	+657.19%
Dec 31, 2023	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.38%	256.61K	3.78M	132.15K	+106.18%
Dec 31, 2023	TREXQUANT INVESTMENT LP	0.39%	265.05K	3.9M	265.05K	+100.00%
Dec 31, 2023	ALLY BRIDGE GROUP (NY) LLC	0.41%	275.77K	4.06M	3.08K	+1.13%
Dec 31, 2023	SCHRODER INVESTMENT MANAGEMENT GROUP	0.44%	295K	4.34M	295K	+100.00%
Dec 31, 2023	DARK FOREST CAPITAL MANAGEMENT LP	0.46%	312.46K	4.6M	212.31K	+211.98%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.58%	387.62K	5.71M	21.76K	+5.95%
Dec 31, 2023	CITIGROUP INC	0.58%	387.66K	5.71M	343.88K	+785.30%
Dec 31, 2023	BOOTHBAY FUND MANAGEMENT, LLC	0.59%	396.5K	5.84M	254.2K	+178.64%
Dec 31, 2023	NORTHERN TRUST CORP	0.65%	435.44K	6.41M	9.66K	+2.27%
Dec 31, 2023	CUBIST SYSTEMATIC STRATEGIES, LLC	0.65%	436.84K	6.43M	236.65K	+118.21%
Dec 31, 2023	HUDSON BAY CAPITAL MANAGEMENT LP	0.68%	460.6K	6.78M	-221.62K	-32.49%
Dec 31, 2023	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.69%	465.45K	6.85M	196.48K	+73.05%
Dec 31, 2023	WOODLINE PARTNERS LP	0.7%	470.8K	6.93M	-428.5K	-47.65%
Dec 31, 2023	QUBE RESEARCH & TECHNOLOGIES LTD	0.72%	482.6K	7.1M	319.89K	+196.60%
Dec 31, 2023	GROUP ONE TRADING, L.P.	0.75%	503.67K	7.41B	466.3K	+1,247.76%
Dec 31, 2023	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.79%	535.01K	7.88M	-1.01M	-65.37%
Dec 31, 2023	AMERICAN CENTURY COMPANIES INC	0.8%	542.55K	7.99M	542.55K	+100.00%
Dec 31, 2023	D. E. SHAW & CO., INC.	0.81%	546.97K	8.05M	-213.33K	-28.06%
Dec 31, 2023	WALLEYE CAPITAL LLC	0.86%	582.73K	8.58M	481.77K	+477.19%
Dec 31, 2023	NANTAHALA CAPITAL MANAGEMENT, LLC	0.92%	620.11K	9.13M	212.91K	+52.28%
Dec 31, 2023	EMERALD MUTUAL FUND ADVISERS TRUST	0.97%	656.53K	9.66M	-24.78K	-3.64%
Dec 31, 2023	EMERALD ADVISERS, LLC	1.19%	802.61K	11.81M	-35.96K	-4.29%
Dec 31, 2023	ALPHA WAVE GLOBAL, LP	1.26%	846.24K	12.46M	-7.02K	-0.82%
Dec 31, 2023	DEUTSCHE BANK AG\	1.27%	853K	12.56M	828.58K	+3,393.61%
Dec 31, 2023	PRICE T ROWE ASSOCIATES INC /MD/	1.33%	894.78K	13.17M	870.56K	+3,594.38%
Dec 31, 2023	MARSHALL WACE, LLP	1.46%	985.11K	14.5M	-212.65K	-17.75%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	1.52%	1.02M	15.04M	21.31K	+2.13%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.53%	1.03M	15.17M	48.65K	+4.95%
Dec 31, 2023	JUPITER ASSET MANAGEMENT LTD	1.57%	1.06M	15.62M	411.16K	+63.28%
Dec 31, 2023	SATURN V CAPITAL MANAGEMENT LLC	1.63%	1.1M	16.18M	213.13K	+24.05%
Dec 31, 2023	EVENTIDE ASSET MANAGEMENT, LLC	1.66%	1.12M	16.44M	0	0
Dec 31, 2023	JANE STREET GROUP, LLC	1.72%	1.16M	17.03M	555.88K	+92.45%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	1.86%	1.26M	18.5M	69.73K	+5.87%
Dec 31, 2023	IKARIAN CAPITAL, LLC	1.3%	877.5K	12.92M	877.5K	+100.00%
Dec 31, 2023	FRANKLIN RESOURCES INC	1.97%	1.33M	19.5M	707.13K	+114.45%
Dec 31, 2023	FMR LLC	2.13%	1.44M	21.14M	997.47K	+227.38%
Dec 31, 2023	STATE STREET CORP	2.14%	1.44M	21.22M	201.65K	+16.27%
Dec 31, 2023	PERCEPTIVE ADVISORS LLC	2.77%	1.87M	27.51M	-819.75K	-30.49%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	3.37%	2.27M	33.45M	153.11K	+7.22%
Dec 31, 2023	STONEPINE CAPITAL MANAGEMENT, LLC	3.71%	2.5M	36.8M	-15.87K	-0.63%
Dec 31, 2023	POINT72 ASSET MANAGEMENT, L.P.	4.08%	2.75M	40.5M	2.75M	+5,980,997.83%
Dec 31, 2023	MORGAN STANLEY	4.2%	2.83M	41.66M	1.88M	+197.26%
Dec 31, 2023	VIKING GLOBAL INVESTORS LP	4.39%	2.96M	43.61M	0	0
Dec 31, 2023	BLACKROCK INC.	5.94%	4M	58.91M	426.88K	+11.94%
Dec 31, 2023	VANGUARD GROUP INC	7.83%	5.28M	77.66M	225.49K	+4.46%
Sep 30, 2023	EMERALD MUTUAL FUND ADVISERS TRUST	1.01%	681.31K	-	1.28K	+0.19%
Sep 30, 2023	HUDSON BAY CAPITAL MANAGEMENT LP	1.01%	682.22K	-	391.32K	+134.52%
Sep 30, 2023	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	0.18%	122.13K	-	-45K	-26.93%
Sep 30, 2023	DAFNA CAPITAL MANAGEMENT LLC	0.18%	122.55K	-	122.55K	+100.00%
Sep 30, 2023	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.19%	124.46K	-	124.46K	+100.00%
Sep 30, 2023	AMERIPRISE FINANCIAL INC	0.19%	129.92K	-	-254	-0.20%
Sep 30, 2023	SCHONFELD STRATEGIC ADVISORS LLC	0.2%	137.52K	-	-72.86K	-34.63%
Sep 30, 2023	ALPHACENTRIC ADVISORS LLC	0.22%	145.5K	-	37.5K	+34.72%
Sep 30, 2023	ALGERT GLOBAL LLC	0.24%	161.41K	-	161.41K	+100.00%
Sep 30, 2023	QUBE RESEARCH & TECHNOLOGIES LTD	0.24%	162.71K	-	38.53K	+31.03%
Sep 30, 2023	BANK OF NEW YORK MELLON CORP	0.24%	163.6K	-	-286	-0.17%
Sep 30, 2023	OBERWEIS ASSET MANAGEMENT INC/	0.25%	170K	-	85K	+100.00%
Sep 30, 2023	SPHERA FUNDS MANAGEMENT LTD.	0.29%	193.65K	-	93.65K	+93.65%
Sep 30, 2023	CUBIST SYSTEMATIC STRATEGIES, LLC	0.3%	200.19K	-	145.94K	+269.03%
Sep 30, 2023	CAPTION MANAGEMENT, LLC	0.34%	227.8K	-	53.8K	+30.92%
Sep 30, 2023	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.4%	268.97K	-	154.34K	+134.64%
Sep 30, 2023	ALLY BRIDGE GROUP (NY) LLC	0.41%	272.69K	-	272.69K	+100.00%
Sep 30, 2023	TRI LOCUM PARTNERS LP	0.42%	282.86K	-	282.86K	+100.00%
Sep 30, 2023	INTERNATIONAL BIOTECHNOLOGY TRUST PLC	0.44%	295K	-	270K	+1,080.00%
Sep 30, 2023	PRIMECAP MANAGEMENT CO/CA/	0.45%	304.9K	-	304.9K	+100.00%
Sep 30, 2023	FEDERATED HERMES, INC.	0.48%	324.26K	-	-1.2M	-78.79%
Sep 30, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.54%	365.86K	-	40.38K	+12.41%
Sep 30, 2023	NORTHERN TRUST CORP	0.63%	425.78K	-	-59.64K	-12.29%
Sep 30, 2023	FMR LLC	0.65%	438.69K	-	-10.3K	-2.29%
Sep 30, 2023	ALTIUM CAPITAL MANAGEMENT LP	0.8%	534.7K	-	349.7K	+189.03%
Sep 30, 2023	BALYASNY ASSET MANAGEMENT L.P.	1.04%	696.88K	-	-476.97K	-40.63%
Sep 30, 2023	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.85%	574.62K	-	61.53K	+11.99%
Sep 30, 2023	GMT CAPITAL CORP	0.86%	576.3K	-	115.3K	+25.01%
Sep 30, 2023	D. E. SHAW & CO., INC.	1.13%	760.29K	-	-829.75K	-52.18%
Sep 30, 2023	JANE STREET GROUP, LLC	0.89%	601.29K	-	127.9K	+27.02%
Sep 30, 2023	FRANKLIN RESOURCES INC	0.92%	617.87K	-	589.38K	+2,069.02%
Sep 30, 2023	VIKING GLOBAL INVESTORS LP	4.41%	2.96M	-	0	0
Sep 30, 2023	PERCEPTIVE ADVISORS LLC	4%	2.69M	-	-2.19M	-44.83%
Sep 30, 2023	STONEPINE CAPITAL MANAGEMENT, LLC	3.74%	2.52M	-	1.39M	+124.43%
Sep 30, 2023	AVIDITY PARTNERS MANAGEMENT LP	2.61%	1.76M	-	855.54K	+94.91%
Sep 30, 2023	ROCK SPRINGS CAPITAL MANAGEMENT LP	2.3%	1.55M	-	400	+0.03%
Sep 30, 2023	GOLDMAN SACHS GROUP INC	1.77%	1.19M	-	-163.35K	-12.10%
Sep 30, 2023	SAMLYN CAPITAL, LLC	1.73%	1.16M	-	1.16M	+100.00%
Sep 30, 2023	VOYA INVESTMENT MANAGEMENT LLC	1.7%	1.15M	-	208.25K	+22.21%
Sep 30, 2023	BLACKROCK INC.	5.32%	3.58M	-	70.17K	+2.00%
Sep 30, 2023	EVENTIDE ASSET MANAGEMENT, LLC	1.66%	1.12M	-	0	0
Sep 30, 2023	NUVEEN ASSET MANAGEMENT, LLC	1.49%	1M	-	447.28K	+80.87%
Sep 30, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.46%	982.07K	-	44.07K	+4.70%
Sep 30, 2023	MORGAN STANLEY	1.42%	952.12K	-	-99.73K	-9.48%
Sep 30, 2023	WOODLINE PARTNERS LP	1.34%	899.3K	-	0	0
Sep 30, 2023	SATURN V CAPITAL MANAGEMENT LLC	1.32%	886.14K	-	886.14K	+100.00%
Sep 30, 2023	ALPHA WAVE GLOBAL, LP	1.27%	853.26K	-	0	0
Sep 30, 2023	EMERALD ADVISERS, LLC	1.25%	838.57K	-	6.76K	+0.81%
Sep 30, 2023	JUPITER ASSET MANAGEMENT LTD	0.97%	649.74K	-	649.74K	+100.00%

Insiders

Among the AMLX insiders holding of 7.62% of the stake in company, MORNINGSIDE VENTURE INVESTMENTS LTD, 10 percent owner, holds the largest shares of 7M. ALS INVEST 1 B.V., , is the second largest AMLX insider with ownership of 5.94M shares. COHEN JOSHUA B, Co-Chief Executive Officer, stands third with possession of 3.33M shares of that stake.

Insiders	Designation	Shares Held
MORNINGSIDE VENTURE INVESTMENTS LTD	10 percent owner	7M
ALS INVEST 1 B.V.		5.94M
COHEN JOSHUA B	Co-Chief Executive Officer	3.33M
KLEE JUSTIN B.	Co-Chief Executive Officer	3.33M
VIKING GLOBAL INVESTORS LP		2.3M
MILNE GEORGE M JR	director	858.57K
OLINGER MARGARET	Chief Commercial Officer	214.36K
YERAMIAN PATRICK D	Chief Medical Officer	205.61K
BEDROSIAN CAMILLE L	Chief Medical Officer	169.3K
FRATES JAMES M	Chief Financial Officer	165.64K
MAZZARIELLO GINA	Chief Legal Officer	134.43K
FIRESTONE KAREN	director	66.9K
ZEIHER BERNHARDT G	director	10K
CHENG ISAAC	director	6.58K
QUIMI DAPHNE	director	5K
FONTEYNE PAUL R.	director	3.95K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
May 21, 2026	FIRESTONE KAREN	PURCHASE	13.51	3.8K	51.34K	66.9K
Mar 02, 2026	MAZZARIELLO GINA	SALE	14.52	6.84K	99.38K	134.43K
Mar 02, 2026	KLEE JUSTIN B.	SALE	14.47	29.28K	423.76K	3.33M
Mar 02, 2026	COHEN JOSHUA B	SALE	14.48	29.28K	424.12K	3.33M
Mar 02, 2026	BEDROSIAN CAMILLE L	SALE	14.58	6.46K	94.21K	169.3K
Mar 02, 2026	FRATES JAMES M	SALE	14.52	7.91K	114.85K	165.64K
Feb 23, 2026	MAZZARIELLO GINA	SALE	14.14	3.42K	48.35K	141.27K
Feb 02, 2026	COHEN JOSHUA B	SALE	14.68	15.5K	227.59K	3.36M
Feb 02, 2026	FRATES JAMES M	SALE	14.65	3.56K	52.1K	173.55K
Feb 02, 2026	KLEE JUSTIN B.	SALE	14.69	15.5K	227.62K	3.36M
Feb 02, 2026	MAZZARIELLO GINA	SALE	14.65	3.45K	50.52K	144.69K
Jan 16, 2026	KLEE JUSTIN B.	SALE	13.89	2K	27.7K	3.38M
Jan 16, 2026	COHEN JOSHUA B	SALE	13.83	1.97K	27.3K	3.38M
Jan 15, 2026	KLEE JUSTIN B.	SALE	13.58	136.19K	1.85M	3.38M
Jan 15, 2026	COHEN JOSHUA B	SALE	13.59	136.19K	1.85M	3.38M
Jan 06, 2026	FRATES JAMES M	SALE	11.11	3.33K	36.95K	177.1K
Jan 06, 2026	COHEN JOSHUA B	SALE	11.09	7.72K	85.6K	3.32M
Jan 06, 2026	KLEE JUSTIN B.	SALE	11.09	7.72K	85.59K	3.32M
Dec 23, 2025	FIRESTONE KAREN	PURCHASE	12.45	8.1K	100.85K	63.1K
Dec 01, 2025	BEDROSIAN CAMILLE L	SALE	14.35	6.58K	94.42K	175.76K
Sep 30, 2025	MAZZARIELLO GINA	SALE	14.58	8.83K	128.67K	148.14K
Sep 30, 2025	FRATES JAMES M	SALE	14.65	10.56K	154.65K	280.43K
Sep 30, 2025	KLEE JUSTIN B.	SALE	15.01	200	3K	3.33M
Sep 30, 2025	BEDROSIAN CAMILLE L	SALE	14.58	12.04K	175.52K	182.34K
Sep 30, 2025	COHEN JOSHUA B	SALE	15.00	200	3K	3.33M
Aug 13, 2025	MAZZARIELLO GINA	SALE	8.34	15K	125.05K	156.97K
Aug 12, 2025	MAZZARIELLO GINA	SALE	8.07	15K	121.1K	171.97K
Mar 31, 2025	FRATES JAMES M	SALE	3.47	10.9K	37.81K	290.99K
Mar 31, 2025	MAZZARIELLO GINA	SALE	3.48	9.19K	31.95K	187.97K
Mar 31, 2025	COHEN JOSHUA B	SALE	3.47	21.49K	74.48K	3.36M
Mar 31, 2025	KLEE JUSTIN B.	SALE	3.46	21.49K	74.45K	3.36M
Mar 31, 2025	BEDROSIAN CAMILLE L	SALE	3.47	12.43K	43.08K	194.38K
Mar 20, 2025	ZEIHER BERNHARDT G	PURCHASE	3.70	10K	37.01K	10K
Mar 03, 2025	MAZZARIELLO GINA	SALE	3.12	1.61K	5.02K	133.31K
Mar 03, 2025	KLEE JUSTIN B.	SALE	3.15	4.6K	14.48K	3.2M
Mar 03, 2025	COHEN JOSHUA B	SALE	3.17	4.6K	14.55K	3.2M
Feb 24, 2025	MAZZARIELLO GINA	SALE	3.15	4.17K	13.14K	134.92K
Feb 03, 2025	MAZZARIELLO GINA	SALE	3.49	3.68K	12.84K	139.09K
Feb 03, 2025	COHEN JOSHUA B	SALE	3.47	11.85K	41.11K	3.2M
Feb 03, 2025	KLEE JUSTIN B.	SALE	3.47	11.86K	41.1K	3.16M
Jan 06, 2025	KLEE JUSTIN B.	SALE	4.04	7.47K	30.2K	3.18M
Jan 06, 2025	COHEN JOSHUA B	SALE	4.05	7.47K	30.23K	3.21M
Dec 02, 2024	BEDROSIAN CAMILLE L	SALE	5.54	5.42K	30.01K	138.38K
Sep 30, 2024	MAZZARIELLO GINA	SALE	3.20	8.71K	27.84K	142.77K
Sep 30, 2024	KLEE JUSTIN B.	SALE	3.20	18.59K	59.43K	3.12M
Sep 30, 2024	COHEN JOSHUA B	SALE	3.20	18.59K	59.41K	3.22M
Sep 30, 2024	BEDROSIAN CAMILLE L	SALE	3.20	11.44K	36.56K	143.8K
Sep 12, 2024	FRATES JAMES M	PURCHASE	2.53	40K	101.37K	233.46K
Sep 05, 2024	FIRESTONE KAREN	PURCHASE	2.13	50K	106.59K	55K
Sep 03, 2024	MILNE GEORGE M JR	PURCHASE	2.20	100K	219.8K	858.57K
May 15, 2024	QUIMI DAPHNE	PURCHASE	1.89	2.25K	4.25K	5K
May 15, 2024	MAZZARIELLO GINA	SALE	1.88	10.46K	19.65K	151.48K
May 14, 2024	QUIMI DAPHNE	PURCHASE	1.89	2.75K	5.18K	2.75K
Mar 05, 2024	KLEE JUSTIN B.	SALE	18.73	4.14K	77.44K	2.96M
Mar 05, 2024	FRATES JAMES M	SALE	18.73	1.79K	33.56K	134.78K
Mar 05, 2024	MAZZARIELLO GINA	SALE	18.73	1.54K	28.84K	81.37K
Mar 05, 2024	COHEN JOSHUA B	SALE	18.73	4.14K	77.44K	3.02M
Feb 23, 2024	MAZZARIELLO GINA	SALE	18.76	2.84K	53.23K	46.25K
Jan 09, 2024	FRATES JAMES M	SALE	16.33	2.72K	44.35K	112.04K
Jan 09, 2024	COHEN JOSHUA B	SALE	16.33	5.84K	95.37K	2.9M
Jan 09, 2024	KLEE JUSTIN B.	SALE	16.33	5.84K	95.37K	2.84M
Jan 09, 2024	YERAMIAN PATRICK D	SALE	16.33	2.81K	45.91K	205.61K
Dec 15, 2023	FIRESTONE KAREN	PURCHASE	14.97	4K	59.88K	5K
Aug 15, 2023	MAZZARIELLO GINA	SALE	20.88	6.16K	128.69K	49.08K
May 16, 2023	FRATES JAMES M	SALE	27.60	500	13.8K	55.68K
May 15, 2023	YERAMIAN PATRICK D	SALE	29.03	11.97K	347.36K	208.42K
Apr 17, 2023	YERAMIAN PATRICK D	SALE	30.94	300	9.28K	208.42K
Mar 29, 2023	MORNINGSIDE VENTURE INVESTMENTS LTD	SALE	30.45	29.05K	884.51K	7M
Mar 28, 2023	MORNINGSIDE VENTURE INVESTMENTS LTD	SALE	30.37	100K	3.04M	7.03M
Mar 27, 2023	MORNINGSIDE VENTURE INVESTMENTS LTD	SALE	30.80	28K	862.4K	7.13M
Mar 21, 2023	MORNINGSIDE VENTURE INVESTMENTS LTD	SALE	32.17	28.81K	926.72K	7.19M
Mar 16, 2023	COHEN JOSHUA B	SALE	32.45	3.92K	127.31K	2.79M
Mar 16, 2023	YERAMIAN PATRICK D	SALE	32.43	2.42K	78.36K	149.67K
Mar 16, 2023	FIRESTONE KAREN	PURCHASE	31.99	1K	31.99K	1K
Mar 16, 2023	MILNE GEORGE M JR	SALE	32.45	1.92K	62.17K	862.02K
Mar 16, 2023	KLEE JUSTIN B.	SALE	32.48	3.45K	111.88K	2.79M
Mar 16, 2023	FRATES JAMES M	SALE	32.46	1.7K	55.32K	1.51K
Mar 16, 2023	MORNINGSIDE VENTURE INVESTMENTS LTD	SALE	32.55	9.12K	296.92K	7.25M
Mar 15, 2023	MORNINGSIDE VENTURE INVESTMENTS LTD	SALE	33.68	41.07K	1.38M	7.26M
Mar 14, 2023	MORNINGSIDE VENTURE INVESTMENTS LTD	SALE	34.54	70.71K	2.44M	7.41M
Mar 02, 2023	MORNINGSIDE VENTURE INVESTMENTS LTD	SALE	33.75	50K	1.69M	7.48M
Feb 24, 2023	MAZZARIELLO GINA	SALE	34.49	3.59K	123.67K	37.41K
Feb 23, 2023	MORNINGSIDE VENTURE INVESTMENTS LTD	SALE	36.24	1.11K	40.26K	7.58M
Feb 22, 2023	MORNINGSIDE VENTURE INVESTMENTS LTD	SALE	36.34	10.08K	366.45K	7.63M
Jan 06, 2023	OLINGER MARGARET	SALE	36.79	743	27.33K	214.36K
Jan 06, 2023	FRATES JAMES M	SALE	36.79	822	30.24K	34.01K
Jan 06, 2023	COHEN JOSHUA B	SALE	36.79	1.85K	67.91K	2.89M
Jan 06, 2023	YERAMIAN PATRICK D	SALE	36.79	629	23.14K	204.3K
Jan 06, 2023	KLEE JUSTIN B.	SALE	36.79	1.85K	67.91K	2.89M
Jul 06, 2022	ALS INVEST 1 B.V.	SALE	19.54	18.31K	357.82K	5.94M
Jan 11, 2022	MORNINGSIDE VENTURE INVESTMENTS LTD	PURCHASE	19.00	263.16K	5M	10.68M
Jan 11, 2022	VIKING GLOBAL INVESTORS LP	PURCHASE	19.00	2.3M	43.7M	2.3M
Jan 06, 2022	OLINGER MARGARET	PURCHASE	19.00	6.84K	130K	216.76K
Jan 06, 2022	FONTEYNE PAUL R.	PURCHASE	19.00	3.95K	74.99K	3.95K
Jan 06, 2022	CHENG ISAAC	PURCHASE	19.00	6.58K	124.98K	6.58K
Jan 06, 2022	MILNE GEORGE M JR	PURCHASE	19.00	26.32K	499.99K	221.4K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE11.9K2

SALES422.89K18

NET SHARES-410.99K16

SHARES HELD34.96M20

% NET SHARES-101.18%-20%

Frequently Asked Questions