How many institutions own ALEC stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own ALEC shares is 203, representing 82.14% of the company's common stock.

Who are the major shareholders selling Alector, Inc. stock?

NUVEEN, LLC, in the last quarter, reduced its stake in ALEC by -14.37% restricting it's holding to 133.25 thousand shares of worth nearly $394.41K. DIADEMA PARTNERS LP also lessened -48.87% of the ALEC shares from its portfolio, reducing its holding to 136.02 thousand shares of worth $402.63K. GEODE CAPITAL MANAGEMENT, LLC also shunned ALEC shares holding by -6.1% last quarter which brought its holding to 1.86 million shares worth $5.51M.

Investors who are buying ALEC stock?

As per its latest 13F filing, BOOTHBAY FUND MANAGEMENT, LLC increased its stake in ALEC by 14.21% in the last quarter. The institutional holder raised its holding to 524.08 thousand shares having worth more than $1.55M. MEDICI CAPITAL LLC also added 188.28% more shares of ALEC to its portfolio, raising its holding to 481.97 thousand shares of worth $1.43M. JPMORGAN CHASE & CO also increased its ALEC shares holding by 199.81% which brought its holding to 136.39 thousand shares worth $403.70K.

ALEC's major insiders: who are they?

The insider with the most stakes in ALEC is MCGUIRE TERRANCE , at the company. Additionally, ALEC stock is highly held by 10 percent owner Polaris Venture Management Co. VI, L.L.C. and Chief Executive Officer Rosenthal Arnon among others.

Did an insider recently sell ALEC stock?

Company executives, directors, and other insiders own 9.94% percent of Alector, Inc.'s stock. Within the last six months, there have been 10 transaction(s) in which ALEC insiders have sold stock, totaling 307.06K shares. Insiders that have sold shares include WONG-SARAD GRACE, ROSENTHAL ARNON, and BERKLEY NEIL LINDSAY.

Which insider recently purchased ALEC stock?

There have been 0 transaction(s) during the past 6-months in which Alector, Inc. insiders have bought stock, totalling 0 shares

How much of ALEC does insiders own?

Around 6.97M Alector, Inc. shares are held by insiders, which represents about 9.94% of ALEC stock.

Who is the insider with the largest stake?

ALEC , MCGUIRE TERRANCE holds the largest portfolio of the company's shares. ALEC shares owned by MCGUIRE total nearly 10.85 million.

Which institution holds the most shares in ALEC?

BOOTHBAY FUND MANAGEMENT, LLC is the largest institutional owner in ALEC which holds 524.08 thousand shares worth $1.55M or 0.52% of the total ALEC shares outstanding followed by MEDICI CAPITAL LLC with ownership of 481.97 thousand shares representing 0.48% of the ALEC ownership. BRIDGEWAY CAPITAL MANAGEMENT, LLC is the third largest stakeholder with 115 thousand shares or 0.11% of the ownership worth more than $340.40K.

Is Alector, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the ALEC is concerned, it is a stock which is optionable.

Is there a short position on ALEC's shares?

Number of ALEC shares short is 6.49M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding ALEC shares are there?

As of today, 109.15M shares of ALEC are outstanding.

Is there many float in ALEC stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, ALEC has 78.19M shares in float.

ALEC short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for ALEC is 5.55.

Alector (ALEC) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares5.95

Short Percent Of Float7.36

Shares Outstanding109.15M

Shares Float78.19M

Shares Short6.49M

Short Ratio5.55

7.36%

Short % of Float

5.95%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

9.94% Percentage of Shares held by All Insiders

82.14% Percentage of Shares held by All Institutions

91.2% Percentage of Float held by Institutions

203

Number of Institutions Holding Shares

Institutional Ownership

About 82.14% of ALEC shares are held by financial institutions. BOOTHBAY FUND MANAGEMENT, LLC is the top corporate investor, holding 524.08K shares valued at $1.55M. A 0.52% stake in Alector, Inc. is owned by the company. MEDICI CAPITAL LLC owns 481.97K shares valued at $1.43M, which translates its holding of 0.48% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.52%	524.08K	1.55M	65.21K	+14.21%
Sep 30, 2025	MEDICI CAPITAL LLC	0.48%	481.97K	1.43M	314.78K	+188.28%
Sep 30, 2025	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.11%	115K	340.4K	0	0
Sep 30, 2025	NUVEEN, LLC	0.13%	133.25K	394.41K	-22.37K	-14.37%
Sep 30, 2025	DIADEMA PARTNERS LP	0.14%	136.02K	402.63K	-130K	-48.87%
Sep 30, 2025	JPMORGAN CHASE & CO	0.14%	136.39K	403.7K	90.89K	+199.81%
Sep 30, 2025	RTW INVESTMENTS, LP	6.96%	6.99M	20.69M	6.99M	+100.00%
Sep 30, 2025	TWO SIGMA ADVISERS, LP	0.52%	517.4K	1.53M	140.4K	+37.24%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.85%	1.86M	5.51M	-120.81K	-6.10%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.18%	2.19M	6.47M	-2.69M	-55.18%
Sep 30, 2025	ACADIAN ASSET MANAGEMENT LLC	2.36%	2.37M	7.02M	202.6K	+9.33%
Sep 30, 2025	MERCK & CO., INC.	3.53%	3.55M	10.5M	0	0
Sep 30, 2025	VANGUARD GROUP INC	6.01%	6.03M	17.86M	46.96K	+0.78%
Sep 30, 2025	BLACKROCK, INC.	7.17%	7.2M	21.31M	-775.61K	-9.73%
Sep 30, 2025	FMR LLC	15.13%	15.18M	44.94M	182.96K	+1.22%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.27%	273.74K	810.26K	-378K	-58.00%
Sep 30, 2025	AMERIPRISE FINANCIAL INC	0.27%	274.04K	811.16K	259.91K	+1,838.75%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.69%	689.52K	2.04M	41.87K	+6.47%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.31%	308.66K	913.63K	104.86K	+51.45%
Sep 30, 2025	LOGOS GLOBAL MANAGEMENT LP	0.5%	500K	1.48M	500K	+100.00%
Sep 30, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.22%	216.57K	641.06K	-97K	-30.93%
Sep 30, 2025	MACKENZIE FINANCIAL CORP	0.28%	283.71K	839.79K	9.27K	+3.38%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.29%	295.85K	876.02K	-87.49K	-22.82%
Sep 30, 2025	PANAGORA ASSET MANAGEMENT INC	0.74%	741.29K	2.19M	224.61K	+43.47%
Sep 30, 2025	IKARIAN CAPITAL, LLC	0.76%	760K	2.25M	-140K	-15.56%
Sep 30, 2025	MARSHALL WACE, LLP	0.15%	151.64K	448.86K	151.64K	+100.00%
Sep 30, 2025	NEW LEAF VENTURE PARTNERS, L.L.C.	0.34%	339.57K	1.01M	0	0
Sep 30, 2025	JANE STREET GROUP, LLC	0.35%	350.23K	1.04M	326.28K	+1,362.22%
Sep 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.44%	438.09K	1.3M	31.47K	+7.74%
Sep 30, 2025	CITADEL ADVISORS LLC	0.47%	471.58K	1.4M	-80.24K	-14.54%
Sep 30, 2025	BARCLAYS PLC	0.87%	873.38K	2.59M	703.58K	+414.37%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.95%	949.15K	2.81M	-305.7K	-24.36%
Sep 30, 2025	VESTAL POINT CAPITAL, LP	0.98%	980K	2.9M	3.01K	+0.31%
Sep 30, 2025	683 CAPITAL MANAGEMENT, LLC	1%	1M	2.96M	1M	+100.00%
Sep 30, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	1.23%	1.23M	3.64M	-91.91K	-6.95%
Sep 30, 2025	UBS GROUP AG	0.23%	230.5K	682.28K	188.61K	+450.21%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.25%	246.28K	729K	-97.63K	-28.39%
Sep 30, 2025	MORGAN STANLEY	0.43%	434.17K	1.29M	-172.38K	-28.42%
Sep 30, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.8%	798.35K	2.36M	-114.58K	-12.55%
Sep 30, 2025	5AM VENTURE MANAGEMENT, LLC	0.99%	995.84K	2.95M	0	0
Sep 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.05%	1.06M	3.12M	0	0
Sep 30, 2025	ROYAL BANK OF CANADA	0.63%	628.65K	1.86M	261.46K	+71.21%
Sep 30, 2025	D. E. SHAW & CO., INC.	0.97%	978.2K	2.9M	444K	+83.12%
Sep 30, 2025	EUCLIDEAN CAPITAL LLC	1.3%	1.31M	3.87M	0	0
Sep 30, 2025	EVERSEPT PARTNERS, LP	1.48%	1.49M	4.41M	-497.35K	-25.04%
Sep 30, 2025	PROSHARE ADVISORS LLC	0.02%	15.43K	45.68K	-4.65K	-23.14%
Sep 30, 2025	DLK INVESTMENT MANAGEMENT, LLC	0.02%	15.5K	45.88K	0	0
Sep 30, 2025	SEI INVESTMENTS CO	0.02%	16.88K	49.98K	0	0
Sep 30, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	17.74K	52.51K	-2.34K	-11.66%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.02%	18.27K	54.08K	6.64K	+57.03%
Sep 30, 2025	ERSTE ASSET MANAGEMENT GMBH	0.02%	19K	57.95K	0	0
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.02%	20.48K	60.62K	20.48K	+100.00%
Sep 30, 2025	GROUP ONE TRADING, L.P.	0.02%	22.32K	66.07M	22.32K	+100.00%
Sep 30, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.02%	23.43K	69.34K	6.42K	+37.77%
Sep 30, 2025	APOLLON WEALTH MANAGEMENT, LLC	0.02%	25K	74K	0	0
Sep 30, 2025	CWM, LLC	0.03%	25.17K	75K	-728	-2.81%
Sep 30, 2025	VONTOBEL HOLDING LTD.	0.03%	26K	76.96K	-12K	-31.58%
Sep 30, 2025	CERITY PARTNERS LLC	0.03%	26.81K	79.35K	3.07K	+12.94%
Sep 30, 2025	PRUDENTIAL FINANCIAL INC	0.03%	28.02K	82.95K	6.7K	+31.42%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	28.82K	85.31K	28.82K	+100.00%
Sep 30, 2025	PERSISTENT ASSET PARTNERS LTD	0.03%	31.24K	92.47K	-29.86K	-48.87%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	33.43K	98.95K	-6.49K	-16.25%
Sep 30, 2025	HSBC HOLDINGS PLC	0.05%	48.67K	139.67K	-3.03K	-5.87%
Sep 30, 2025	BANK OF MONTREAL /CAN/	0.05%	52.38K	155.05K	0	0
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.05%	52.43K	155.18K	1.82K	+3.60%
Sep 30, 2025	CITIGROUP INC	0.05%	53.94K	159.66K	4.48K	+9.05%
Sep 30, 2025	VANGUARD PERSONALIZED INDEXING MANAGEMENT, LLC	0.06%	58.32K	172.63K	6.23K	+11.95%
Sep 30, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.09%	91.24K	270.06K	-60.66K	-39.94%
Sep 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.1%	100K	303K	0	0
Sep 30, 2025	SIMPLEX TRADING, LLC	0.1%	100.94K	298K	100.94K	+100.00%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.1%	104.82K	310.28K	4.46K	+4.44%
Sep 30, 2025	STRS OHIO	0.11%	110.4K	326.78K	0	0
Sep 30, 2025	RHUMBLINE ADVISERS	0.11%	114.27K	338.23K	-12.3K	-9.72%
Sep 30, 2025	ALPHABET INC.	0.18%	175.87K	520.56K	0	0
Sep 30, 2025	INVESCO LTD.	0.19%	192.31K	569.24K	16.51K	+9.39%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.22%	224.48K	664.47K	-44.39K	-16.51%
Sep 30, 2025	STATE STREET CORP	1.73%	1.73M	5.13M	24.78K	+1.45%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	0.61%	609.91K	1.81M	235.43K	+62.87%
Sep 30, 2025	DEUTSCHE BANK AG\	1.06%	1.07M	3.16M	78.47K	+7.93%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	1.15%	1.16M	3.42M	744.22K	+181.16%
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.31%	307.18K	909.25K	85.04K	+38.28%
Sep 30, 2025	NORTHERN TRUST CORP	0.63%	633.71K	1.88M	-24.45K	-3.72%
Jun 30, 2025	JASPER RIDGE PARTNERS, L.P.	0.03%	30.63K	42.89K	0	0
Jun 30, 2025	VONTOBEL HOLDING LTD.	0.04%	38K	53.2K	8K	+26.67%
Jun 30, 2025	CITADEL ADVISORS LLC	0.55%	551.82K	772.55K	546.38K	+10,047.48%
Jun 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.04%	39.92K	55.88K	-20.84K	-34.30%
Jun 30, 2025	TUDOR INVESTMENT CORP ET AL	0.04%	40.8K	57.11K	-1	0.00%
Jun 30, 2025	ALGERT GLOBAL LLC	0.04%	44.46K	62K	0	0
Jun 30, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0.05%	46.29K	64.8K	-28.36K	-37.99%
Jun 30, 2025	UTAH RETIREMENT SYSTEMS	0.05%	51.43K	72K	0	0
Jun 30, 2025	VANGUARD PERSONALIZED INDEXING MANAGEMENT, LLC	0.05%	52.1K	72.93K	17.17K	+49.16%
Jun 30, 2025	VELAN CAPITAL INVESTMENT MANAGEMENT LP	0.05%	55K	77K	0	0
Jun 30, 2025	IEQ CAPITAL, LLC	0.06%	59K	82.6K	-21.41K	-26.62%
Jun 30, 2025	SPEARS ABACUS ADVISORS LLC	0.06%	61.51K	86.12K	-100	-0.16%
Jun 30, 2025	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.07%	70.78K	99.09K	-67.13K	-48.68%
Jun 30, 2025	XTX TOPCO LTD	0.07%	73.34K	102.67K	40.77K	+125.16%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.09%	92.94K	130.12M	10.84K	+13.20%
Jun 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.1%	100K	148K	0	0
Jun 30, 2025	IKARIAN CAPITAL, LLC	0.9%	900K	1.26M	-50K	-5.26%
Jun 30, 2025	STATE STREET CORP	1.7%	1.71M	2.39M	69.64K	+4.25%
Jun 30, 2025	DLK INVESTMENT MANAGEMENT, LLC	0.02%	15.5K	21.7K	4K	+34.78%
Jun 30, 2025	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0%	3.86K	5.41K	547	+16.50%
Jun 30, 2025	TEXAS YALE CAPITAL CORP.	0.01%	10K	14K	0	0
Jun 30, 2025	SHELL ASSET MANAGEMENT CO	0.01%	13.89K	19K	-6.74K	-32.68%
Jun 30, 2025	ACADIAN ASSET MANAGEMENT LLC	2.16%	2.17M	3.03M	729.73K	+50.65%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.65%	647.65K	906.71K	22.92K	+3.67%
Jun 30, 2025	MORGAN STANLEY	0.6%	606.55K	849.17K	259.85K	+74.95%
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	1.25%	1.25M	1.76M	221K	+21.38%
Jun 30, 2025	EUCLIDEAN CAPITAL LLC	1.3%	1.31M	1.83M	0	0
Jun 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	1.72%	1.72M	2.41M	1.34M	+353.17%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.97%	1.98M	2.78M	19.97K	+1.02%
Jun 30, 2025	EVERSEPT PARTNERS, LP	1.98%	1.99M	2.78M	1.37M	+221.67%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	4.86%	4.88M	6.83M	4.2M	+620.86%
Jun 30, 2025	FMR LLC	14.94%	15M	21M	608.65K	+4.23%
Jun 30, 2025	MERCK & CO., INC.	3.53%	3.55M	4.96M	0	0
Jun 30, 2025	VANGUARD GROUP INC	5.97%	5.99M	8.38M	-65.34K	-1.08%
Jun 30, 2025	BLACKROCK, INC.	7.94%	7.97M	11.16M	-306.12K	-3.70%
Jun 30, 2025	GSA CAPITAL PARTNERS LLP	0.15%	150.67K	211K	150.67K	+100.00%
Jun 30, 2025	DIVERSIFIED TRUST CO	0.01%	14.1K	19.74K	0	0
Jun 30, 2025	WALLEYE CAPITAL LLC	0.27%	266.2K	372.69K	-39.4K	-12.89%
Jun 30, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.91%	912.93K	1.28M	0	0
Jun 30, 2025	DEUTSCHE BANK AG\	0.99%	989.75K	1.39M	-111.8K	-10.15%
Jun 30, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	1.32%	1.32M	1.85M	-11.15K	-0.84%
Jun 30, 2025	D. E. SHAW & CO., INC.	0.53%	534.2K	747.88K	64.9K	+13.83%
Jun 30, 2025	TD ASSET MANAGEMENT INC	0.65%	651.74K	912.43K	540K	+483.27%
Jun 30, 2025	SIO CAPITAL MANAGEMENT, LLC	0.84%	845.53K	1.18M	8.37K	+1.00%
Jun 30, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.15%	151.9K	212.65K	7.6K	+5.27%
Jun 30, 2025	NUVEEN, LLC	0.16%	155.61K	217.86K	17.43K	+12.62%
Jun 30, 2025	MEDICI CAPITAL LLC	0.17%	167.19K	234.07K	0	0
Jun 30, 2025	BARCLAYS PLC	0.17%	169.8K	238K	44.71K	+35.74%
Jun 30, 2025	INVESCO LTD.	0.18%	175.8K	246.12K	27.23K	+18.32%
Jun 30, 2025	DIADEMA PARTNERS LP	0.27%	266.02K	372.43K	-190.52K	-41.73%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.27%	268.87K	376.42K	19.38K	+7.77%
Jun 30, 2025	ALPHABET INC.	0.18%	175.87K	246.21K	0	0
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.2%	203.8K	285.32K	-49.32K	-19.49%
Jun 30, 2025	TWO SIGMA INVESTMENTS, LP	0.22%	222.14K	311K	7.71K	+3.60%
Jun 30, 2025	STATE OF WYOMING	0.22%	223.09K	312.33K	26.28K	+13.35%
Jun 30, 2025		0.16%	155.61K	217.86K	17.43K	+12.62%
Jun 30, 2025	MACKENZIE FINANCIAL CORP	0.27%	274.44K	384.22K	274.44K	+100.00%
Jun 30, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.31%	313.58K	439.01K	189.69K	+153.11%
Jun 30, 2025	NEW LEAF VENTURE PARTNERS, L.L.C.	0.34%	339.57K	475.4K	0	0
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.34%	343.91K	481.47K	5.93K	+1.75%
Jun 30, 2025	ROYAL BANK OF CANADA	0.37%	367.19K	513K	362.4K	+7,560.92%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.37%	374.48K	524.27K	62.33K	+19.97%
Jun 30, 2025	TWO SIGMA ADVISERS, LP	0.38%	377K	527.8K	-15.9K	-4.05%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.38%	383.33K	536.94K	-106K	-21.66%
Jun 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.41%	406.62K	569.27K	-85.97K	-17.45%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.41%	410.8K	575.12K	145.99K	+55.13%
Jun 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.46%	458.86K	642.41K	184.5K	+67.25%
Jun 30, 2025	PANAGORA ASSET MANAGEMENT INC	0.51%	516.68K	723.35K	150.14K	+40.96%
Jun 30, 2025	NORTHERN TRUST CORP	0.66%	658.16K	921.43K	-39.07K	-5.60%
Jun 30, 2025	VESTAL POINT CAPITAL, LP	0.97%	976.99K	1.37M	472.45K	+93.64%
Jun 30, 2025	5AM VENTURE MANAGEMENT, LLC	0.99%	995.84K	1.39M	0	0
Jun 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.05%	1.06M	1.48M	0	0
Jun 30, 2025	FNY INVESTMENT ADVISERS, LLC	0.02%	20K	28K	10K	+100.00%
Jun 30, 2025	GRAHAM CAPITAL MANAGEMENT, L.P.	0.02%	21.37K	29.92K	-19.73K	-48.00%
Jun 30, 2025	CERITY PARTNERS LLC	0.02%	23.74K	33.23K	-17.83K	-42.89%
Jun 30, 2025	APOLLON WEALTH MANAGEMENT, LLC	0.02%	25K	35K	0	0
Jun 30, 2025	BLACKSTONE INC.	0.03%	25.72K	36K	0	0
Mar 31, 2025	SIO CAPITAL MANAGEMENT, LLC	0.84%	837.16K	1.03M	221.53K	+35.98%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.63%	624.73K	768.42K	-18.73K	-2.91%
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.38%	380.33K	467.81K	12K	+3.26%
Mar 31, 2025	ALPHABET INC.	0.18%	175.87K	216.32K	0	0
Mar 31, 2025	FMR LLC	14.48%	14.39M	17.7M	-299.63K	-2.04%
Mar 31, 2025	BLACKROCK, INC.	8.33%	8.28M	10.18M	-857.05K	-9.38%
Mar 31, 2025		0.14%	138.18K	646.04K	138.18K	+100.00%
Mar 31, 2025	DEUTSCHE BANK AG\	1.11%	1.1M	1.35M	-4.74K	-0.43%
Mar 31, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.06%	1.06M	1.3M	-11.77K	-1.10%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	1.04%	1.03M	1.27M	118.12K	+12.90%
Mar 31, 2025	5AM VENTURE MANAGEMENT, LLC	1%	995.84K	1.22M	0	0
Mar 31, 2025	AQR CAPITAL MANAGEMENT LLC	0.5%	492.59K	605.89K	-70.34K	-12.50%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.49%	489.33K	602.09K	-392.79K	-44.53%
Mar 31, 2025	D. E. SHAW & CO., INC.	0.47%	469.3K	577.24K	100.32K	+27.19%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.22%	214.43K	263.74K	-193.56K	-47.44%
Mar 31, 2025	STATE OF WYOMING	0.2%	196.81K	242.08K	196.81K	+100.00%
Mar 31, 2025	MEDICI CAPITAL LLC	0.17%	167.19K	205.65K	0	0
Mar 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.16%	157.31K	193.49K	-8.28K	-5.00%
Mar 31, 2025	INVESCO LTD.	0.15%	148.58K	182.75K	100.59K	+209.63%
Mar 31, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.15%	144.3K	177.48K	53.56K	+59.03%
Mar 31, 2025	TWO SIGMA ADVISERS, LP	0.4%	392.9K	483.27K	-37K	-8.61%
Mar 31, 2025	PANAGORA ASSET MANAGEMENT INC	0.37%	366.55K	450.85K	-2.53K	-0.69%
Mar 31, 2025	MORGAN STANLEY	0.35%	346.71K	426.45K	-303.83K	-46.70%
Mar 31, 2025	NEW LEAF VENTURE PARTNERS, L.L.C.	0.34%	339.57K	417.67K	0	0
Mar 31, 2025	JANE STREET GROUP, LLC	0.26%	256.55K	315.56K	11.62K	+4.74%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.25%	253.12K	311.34K	53.36K	+26.71%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.25%	249.49K	306.88K	18.77K	+8.13%
Mar 31, 2025	VANGUARD GROUP INC	6.09%	6.05M	7.45M	436.66K	+7.77%
Mar 31, 2025	MERCK & CO., INC.	3.57%	3.55M	4.36M	0	0
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.97%	1.96M	2.41M	47.85K	+2.50%
Mar 31, 2025	STATE STREET CORP	1.65%	1.64M	2.02M	-209.03K	-11.30%
Mar 31, 2025	JPMORGAN CHASE & CO	1.5%	1.49M	1.83M	-156.42K	-9.52%
Mar 31, 2025	ACADIAN ASSET MANAGEMENT LLC	1.45%	1.44M	1.77M	410.21K	+39.81%
Mar 31, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	1.34%	1.33M	1.64M	274.34K	+25.89%
Mar 31, 2025	EUCLIDEAN CAPITAL LLC	1.32%	1.31M	1.61M	0	0
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.27%	264.82K	325.72K	190.13K	+254.58%
Mar 31, 2025	ALMITAS CAPITAL LLC	0.32%	321.57K	395.53K	36.72K	+12.89%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.31%	312.15K	383.94K	-96.93K	-23.70%
Mar 31, 2025	WALLEYE CAPITAL LLC	0.31%	305.6K	375.89K	158.92K	+108.35%
Mar 31, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.28%	274.36K	337.46K	-19.8K	-6.73%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.34%	337.98K	415.72K	19.33K	+6.07%
Mar 31, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.92%	912.93K	1.12M	0	0
Mar 31, 2025	FRANKLIN RESOURCES INC	0.84%	834.27K	1.03M	-96.26K	-10.35%
Mar 31, 2025	NORTHERN TRUST CORP	0.7%	697.23K	857.59K	-62.65K	-8.24%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.68%	676.31K	832K	-69.78K	-9.35%
Mar 31, 2025	EVERSEPT PARTNERS, LP	0.62%	617.42K	759.42K	417.32K	+208.56%
Mar 31, 2025	VESTAL POINT CAPITAL, LP	0.51%	504.54K	620.58K	504.54K	+100.00%
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	9.75%	9.7M	11.93M	0	0
Mar 31, 2025	IKARIAN CAPITAL, LLC	0.96%	950K	1.17M	0	0
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.4%	339.88K	2.05M	-92.81K	-21.45%
Mar 31, 2024	CITIGROUP INC	0.29%	240.98K	1.45M	158.43K	+191.94%
Mar 31, 2024	WALLEYE CAPITAL LLC	0.3%	252.81K	1.52M	-9.32K	-3.55%
Mar 31, 2024	ALYESKA INVESTMENT GROUP, L.P.	0.3%	256.18K	1.54M	256.18K	+100.00%
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	0.33%	275.63K	1.66M	84.72K	+44.38%
Mar 31, 2024	FMR LLC	17.02%	14.36M	86.46M	1.74M	+13.80%
Mar 31, 2024	VANGUARD GROUP INC	5.82%	4.91M	29.57M	526.04K	+11.99%
Mar 31, 2024	ECOR1 CAPITAL, LLC	4.81%	4.06M	24.42M	0	0
Mar 31, 2024	VERITION FUND MANAGEMENT LLC	1.48%	1.25M	7.54M	1.11M	+755.63%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.8%	675.48K	4.07M	103.5K	+18.09%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.8%	674.79K	4.06M	175.26K	+35.09%
Mar 31, 2024	SPHERA FUNDS MANAGEMENT LTD.	0.66%	560K	3.37M	560K	+100.00%
Mar 31, 2024	TWO SIGMA ADVISERS, LP	0.64%	539.5K	3.25M	146.4K	+37.24%
Mar 31, 2024	EVERSEPT PARTNERS, LP	0.64%	536.17K	3.23M	536.17K	+100.00%
Mar 31, 2024	ACADIAN ASSET MANAGEMENT LLC	0.53%	444.65K	2.68M	301.94K	+211.57%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.43%	364.63K	2.2M	172.08K	+89.37%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.27%	230.31K	1.39M	21.26K	+10.17%
Mar 31, 2024	UBS GROUP AG	0.27%	229.49K	1.38M	50.79K	+28.43%
Mar 31, 2024	PANAGORA ASSET MANAGEMENT INC	0.26%	219.7K	1.32M	-16.94K	-7.16%
Mar 31, 2024	AQR CAPITAL MANAGEMENT LLC	0.23%	190.21K	1.15M	124.54K	+189.66%
Mar 31, 2024	WOODLINE PARTNERS LP	0.23%	190K	1.14M	190K	+100.00%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.38%	319.27K	1.92M	33.37K	+11.67%
Mar 31, 2024	STIFEL FINANCIAL CORP	0.17%	146.69K	883.07K	929	+0.64%
Mar 31, 2024	ALPHABET INC.	0.21%	175.87K	1.06M	0	0
Mar 31, 2024	MARSHALL WACE, LLP	0.21%	177.28K	1.07M	177.28K	+100.00%
Mar 31, 2024	MEDICI CAPITAL LLC	0.22%	185.93K	1.12M	-6.82K	-3.54%
Mar 31, 2024	NORDEA INVESTMENT MANAGEMENT AB	0.22%	188.77K	1.16M	-1.52K	-0.80%
Mar 31, 2024	BAILLIE GIFFORD & CO	0.38%	322.83K	1.94M	-23.1K	-6.68%
Mar 31, 2024	D. E. SHAW & CO., INC.	0.39%	329.63K	1.98M	145.48K	+79.00%
Mar 31, 2024	NEW LEAF VENTURE PARTNERS, L.L.C.	0.4%	339.57K	2.04M	0	0
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.42%	353.65K	2.13M	-86.66K	-19.68%
Mar 31, 2024	NORTHERN TRUST CORP	0.79%	670.22K	4.03M	55.67K	+9.06%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.86%	725.69K	4.37M	233.4K	+47.41%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	1%	845.96K	5.09M	81.57K	+10.67%
Mar 31, 2024	PRICE T ROWE ASSOCIATES INC /MD/	1.06%	890.49K	5.36M	-311.06K	-25.89%
Mar 31, 2024	DAFNA CAPITAL MANAGEMENT LLC	1.08%	912.93K	5.5M	303.02K	+49.68%
Mar 31, 2024	JACOBS LEVY EQUITY MANAGEMENT, INC	1.09%	922.8K	5.56M	128.52K	+16.18%
Mar 31, 2024	FRANKLIN RESOURCES INC	1.14%	959.52K	5.78M	0	0
Mar 31, 2024	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.27%	1.07M	6.46M	5.04K	+0.47%
Mar 31, 2024	EUCLIDEAN CAPITAL LLC	1.55%	1.31M	7.87M	0	0
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	1.87%	1.58M	9.49M	193.98K	+14.04%
Mar 31, 2024	JUPITER ASSET MANAGEMENT LTD	0.28%	232.22K	1.4M	0	0
Mar 31, 2024	DEUTSCHE BANK AG\	3.13%	2.64M	15.91M	580.77K	+28.16%
Mar 31, 2024	MORGAN STANLEY	3.92%	3.3M	19.9M	-1.35M	-28.93%
Mar 31, 2024	DEEP TRACK CAPITAL, LP	4.47%	3.77M	22.69M	3.77M	+100.00%
Mar 31, 2024	STATE STREET CORP	4.64%	3.92M	23.57M	797.64K	+25.59%
Mar 31, 2024	TREXQUANT INVESTMENT LP	0.05%	42.44K	255.51K	-2.13K	-4.77%
Mar 31, 2024	PROFUND ADVISORS LLC	0.05%	43.32K	260.8M	11.66K	+36.80%
Mar 31, 2024	BNP PARIBAS ARBITRAGE, SNC	0.05%	43.93K	264.44K	-51.03K	-53.74%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.06%	48.83K	293.93K	48.83K	+100.00%
Mar 31, 2024	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.06%	52.64K	325.62K	-8.6K	-14.04%
Mar 31, 2024	STATE OF WISCONSIN INVESTMENT BOARD	0.07%	55.02K	331.19K	-74.02K	-57.36%
Mar 31, 2024	LOS ANGELES CAPITAL MANAGEMENT LLC	0.07%	58.76K	353.71K	0	0
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.07%	58.86K	354.34M	-781	-1.31%
Mar 31, 2024	NEW YORK LIFE INVESTMENT MANAGEMENT LLC	0.07%	59.83K	360.17K	59.83K	+100.00%
Mar 31, 2024	GSA CAPITAL PARTNERS LLP	0.08%	63.58K	383K	63.58K	+100.00%
Mar 31, 2024	FEDERATED HERMES, INC.	0.08%	65.83K	396.29K	1.31K	+2.02%
Mar 31, 2024	SPEARS ABACUS ADVISORS LLC	0.08%	66.18K	398.39K	66.18K	+100.00%
Mar 31, 2024	ALPS ADVISORS INC	0.08%	67.53K	406.54K	10.74K	+18.91%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.08%	71.43K	430K	-1.15K	-1.59%
Mar 31, 2024	RUSSELL INVESTMENTS GROUP, LTD.	0.09%	78.35K	471.65K	7.07K	+9.91%
Mar 31, 2024	CREDIT SUISSE AG/	0.11%	90.72K	546.1K	5.42K	+6.35%
Mar 31, 2024	STRS OHIO	0.11%	91.2K	549K	18K	+24.59%
Mar 31, 2024	RHUMBLINE ADVISERS	0.11%	91.53K	550.97K	3.93K	+4.48%
Mar 31, 2024	DEKABANK DEUTSCHE GIROZENTRALE	0.12%	100K	605K	0	0
Mar 31, 2024	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.13%	109.13K	656.96K	87.85K	+412.83%
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.13%	111.74K	672.66M	0	0
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.14%	117.99K	710.32K	0	0
Mar 31, 2024	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.15%	126.16K	759.51K	126.16K	+100.00%
Mar 31, 2024	VICTORY CAPITAL MANAGEMENT INC	0.15%	129.14K	777.42K	3.75K	+2.99%
Mar 31, 2024	SWISS NATIONAL BANK	0.16%	131.9K	794.04K	8K	+6.46%
Mar 31, 2024	POINT72 ASSET MANAGEMENT, L.P.	0.82%	695.3K	4.19M	556.3K	+400.22%
Mar 31, 2024	JPMORGAN CHASE & CO	2.03%	1.72M	10.33M	-148.23K	-7.95%
Mar 31, 2024	BRAIDWELL LP	2.82%	2.38M	14.33M	-943.6K	-28.39%
Mar 31, 2024	BLACKROCK INC.	10.05%	8.48M	51.07M	415.01K	+5.14%
Dec 31, 2023	BLACKROCK INC.	9.61%	8.07M	64.39M	337.58K	+4.37%
Dec 31, 2023	SWISS NATIONAL BANK	0.15%	123.9K	988.72K	-11.7K	-8.63%
Dec 31, 2023	VICTORY CAPITAL MANAGEMENT INC	0.15%	125.39K	1M	-9.33K	-6.92%
Dec 31, 2023	STATE OF WISCONSIN INVESTMENT BOARD	0.15%	129.03K	1.03M	-18.71K	-12.66%
Dec 31, 2023	POINT72 ASSET MANAGEMENT, L.P.	0.17%	139K	1.11M	-599.78K	-81.19%
Dec 31, 2023	FMR LLC	15.04%	12.62M	100.71M	448.36K	+3.68%
Dec 31, 2023	ACADIAN ASSET MANAGEMENT LLC	0.17%	142.71K	1.14M	-10.56K	-6.89%
Dec 31, 2023	STIFEL FINANCIAL CORP	0.17%	145.76K	1.16M	119.61K	+457.40%
Dec 31, 2023	VERITION FUND MANAGEMENT LLC	0.17%	146.45K	1.17M	-20.56K	-12.31%
Dec 31, 2023	CUBIST SYSTEMATIC STRATEGIES, LLC	0.19%	162.83K	1.3M	153.21K	+1,593.14%
Dec 31, 2023	ALPHABET INC.	0.21%	175.87K	1.4M	0	0
Dec 31, 2023	UBS GROUP AG	0.21%	178.69K	1.43M	99.01K	+124.26%
Dec 31, 2023	D. E. SHAW & CO., INC.	0.22%	184.15K	1.47M	65.13K	+54.72%
Dec 31, 2023	NORDEA INVESTMENT MANAGEMENT AB	0.23%	190.29K	1.5M	-12.42K	-6.13%
Dec 31, 2023	RAFFERTY ASSET MANAGEMENT, LLC	0.23%	190.91K	1.52M	4.29K	+2.30%
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	0.23%	192.55K	1.54M	90.12K	+87.98%
Dec 31, 2023	MEDICI CAPITAL LLC	0.23%	192.75K	1.54M	133.09K	+223.11%
Dec 31, 2023	BARCLAYS PLC	0.23%	193.23K	1.54M	54.4K	+39.19%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.25%	209.05K	1.67M	-22.94K	-9.89%
Dec 31, 2023	JUPITER ASSET MANAGEMENT LTD	0.28%	232.22K	1.85M	0	0
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	0.28%	235.64K	1.88M	-121.13K	-33.95%
Dec 31, 2023	PANAGORA ASSET MANAGEMENT INC	0.28%	236.65K	1.89M	-56.89K	-19.38%
Dec 31, 2023	HRT FINANCIAL LP	0.28%	239.12K	1.91M	45.82K	+23.71%
Dec 31, 2023	CAMPBELL & CO INVESTMENT ADVISER LLC	0.29%	240.63K	1.92M	240.63K	+100.00%
Dec 31, 2023	WALLEYE CAPITAL LLC	0.31%	262.13K	2.09M	262.13K	+100.00%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.34%	285.89K	2.28M	37.67K	+15.18%
Dec 31, 2023	NEW LEAF VENTURE PARTNERS, L.L.C.	0.4%	339.57K	2.71M	0	0
Dec 31, 2023	BAILLIE GIFFORD & CO	0.41%	345.92K	2.76M	-22.05K	-5.99%
Dec 31, 2023	TWO SIGMA ADVISERS, LP	0.47%	393.1K	3.14M	4.1K	+1.05%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.52%	432.69K	3.45M	1.15K	+0.27%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.52%	440.32K	3.51M	15.7K	+3.70%
Dec 31, 2023	ALLIANCEBERNSTEIN L.P.	0.59%	492.29K	3.93M	162.66K	+49.35%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.6%	499.53K	3.99M	17.31K	+3.59%
Dec 31, 2023	RENAISSANCE TECHNOLOGIES LLC	0.68%	571.98K	4.56M	69.78K	+13.89%
Dec 31, 2023	DAFNA CAPITAL MANAGEMENT LLC	0.73%	609.91K	4.87M	-19.03K	-3.03%
Dec 31, 2023	NORTHERN TRUST CORP	0.73%	614.56K	4.9M	-21.51K	-3.38%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	0.91%	764.39K	6.1M	83.17K	+12.21%
Dec 31, 2023	JACOBS LEVY EQUITY MANAGEMENT, INC	0.95%	794.28K	6.34M	16.21K	+2.08%
Dec 31, 2023	FRANKLIN RESOURCES INC	1.14%	959.52K	7.66M	362	+0.04%
Dec 31, 2023	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.27%	1.07M	8.52M	12.62K	+1.20%
Dec 31, 2023	PRICE T ROWE ASSOCIATES INC /MD/	1.43%	1.2M	9.59M	54.58K	+4.76%
Dec 31, 2023	EUCLIDEAN CAPITAL LLC	1.56%	1.31M	10.44M	0	0
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.65%	1.38M	11.03M	78.71K	+6.04%
Dec 31, 2023	JPMORGAN CHASE & CO	2.22%	1.86M	14.87M	-424.37K	-18.54%
Dec 31, 2023	DEUTSCHE BANK AG\	2.46%	2.06M	16.46M	2.03M	+6,104.23%
Dec 31, 2023	STATE STREET CORP	3.71%	3.12M	24.88M	280.82K	+9.90%
Dec 31, 2023	BRAIDWELL LP	3.96%	3.32M	26.53M	-749.81K	-18.40%
Dec 31, 2023	ECOR1 CAPITAL, LLC	4.83%	4.06M	32.37M	0	0
Dec 31, 2023	VANGUARD GROUP INC	5.23%	4.39M	35M	-1.13M	-20.55%
Dec 31, 2023	MORGAN STANLEY	5.54%	4.65M	37.11M	1.31M	+39.34%
Sep 30, 2023	NORDEA INVESTMENT MANAGEMENT AB	0.24%	202.71K	-	69	+0.03%
Sep 30, 2023	JUPITER ASSET MANAGEMENT LTD	0.28%	232.22K	-	0	0
Sep 30, 2023	GOLDMAN SACHS GROUP INC	0.3%	248.22K	-	-58.27K	-19.01%
Sep 30, 2023	PANAGORA ASSET MANAGEMENT INC	0.35%	293.53K	-	51.44K	+21.25%
Sep 30, 2023	ALLIANCEBERNSTEIN L.P.	0.39%	329.62K	-	134.93K	+69.31%
Sep 30, 2023	NEW LEAF VENTURE PARTNERS, L.L.C.	0.41%	339.57K	-	0	0
Sep 30, 2023	BAILLIE GIFFORD & CO	0.44%	367.97K	-	-17.09K	-4.44%
Sep 30, 2023	TWO SIGMA ADVISERS, LP	0.47%	389K	-	-55.9K	-12.56%
Sep 30, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.52%	431.55K	-	1.51K	+0.35%
Sep 30, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.58%	482.22K	-	12.57K	+2.68%
Sep 30, 2023	DAFNA CAPITAL MANAGEMENT LLC	0.75%	628.94K	-	-10K	-1.57%
Sep 30, 2023	NORTHERN TRUST CORP	0.76%	636.07K	-	20.2K	+3.28%
Sep 30, 2023	DIMENSIONAL FUND ADVISORS LP	0.82%	681.23K	-	128.4K	+23.23%
Sep 30, 2023	POINT72 ASSET MANAGEMENT, L.P.	0.88%	738.78K	-	-992.37K	-57.32%
Sep 30, 2023	JACOBS LEVY EQUITY MANAGEMENT, INC	0.93%	778.08K	-	195.41K	+33.54%
Sep 30, 2023	FRANKLIN RESOURCES INC	1.15%	959.16K	-	-652.26K	-40.48%
Sep 30, 2023	BAKER BROS. ADVISORS LP	1.16%	964.85K	-	0	0
Sep 30, 2023	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.26%	1.06M	-	0	0
Sep 30, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.56%	1.3M	-	13.36K	+1.04%
Sep 30, 2023	EUCLIDEAN CAPITAL LLC	1.57%	1.31M	-	326.96K	+33.33%
Sep 30, 2023	MORGAN STANLEY	4%	3.34M	-	1.61M	+92.68%
Sep 30, 2023	ECOR1 CAPITAL, LLC	4.86%	4.06M	-	0	0
Sep 30, 2023	BLACKROCK INC.	9.26%	7.73M	-	-94.58K	-1.21%
Sep 30, 2023	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0.08%	69.26K	-	-6.63K	-8.74%
Sep 30, 2023	STRS OHIO	0.09%	73.2K	-	0	0
Sep 30, 2023	AMERICAN CENTURY COMPANIES INC	0.09%	75.67K	-	-28.55K	-27.40%
Sep 30, 2023	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.09%	78.21K	-	82	+0.11%
Sep 30, 2023	CITIGROUP INC	0.1%	79.52K	-	-388	-0.49%
Sep 30, 2023	UBS GROUP AG	0.1%	79.68K	-	-11.36K	-12.48%
Sep 30, 2023	AMERIPRISE FINANCIAL INC	0.1%	80.07K	-	-91.05K	-53.21%
Sep 30, 2023	BNP PARIBAS ARBITRAGE, SNC	0.1%	80.67K	-	28.77K	+55.43%
Sep 30, 2023	CREDIT SUISSE AG/	0.1%	83.68K	-	5.57K	+7.14%
Sep 30, 2023	RHUMBLINE ADVISERS	0.11%	87.68K	-	-2.93K	-3.24%
Sep 30, 2023	DEKABANK DEUTSCHE GIROZENTRALE	0.12%	100K	-	0	0
Sep 30, 2023	FMR LLC	14.58%	12.17M	-	4.48M	+58.27%
Sep 30, 2023	TWO SIGMA INVESTMENTS, LP	0.12%	102.43K	-	-185.29K	-64.40%
Sep 30, 2023	D. E. SHAW & CO., INC.	0.14%	119.02K	-	100.82K	+554.12%
Sep 30, 2023	TD ASSET MANAGEMENT INC	0.14%	119.14K	-	107.87K	+957.22%
Sep 30, 2023	RUSSELL INVESTMENTS GROUP, LTD.	0.14%	120.12K	-	20.11K	+20.10%
Sep 30, 2023	VICTORY CAPITAL MANAGEMENT INC	0.16%	134.72K	-	-14.77K	-9.88%
Sep 30, 2023	SWISS NATIONAL BANK	0.16%	135.6K	-	0	0
Sep 30, 2023	BARCLAYS PLC	0.17%	138.83K	-	26.86K	+23.99%
Sep 30, 2023	STATE OF WISCONSIN INVESTMENT BOARD	0.18%	147.74K	-	3.61K	+2.51%
Sep 30, 2023	ACADIAN ASSET MANAGEMENT LLC	0.18%	153.27K	-	62.16K	+68.22%
Sep 30, 2023	FEDERATED HERMES, INC.	0.19%	155.66K	-	-332.08K	-68.09%
Sep 30, 2023	LOS ANGELES CAPITAL MANAGEMENT LLC	0.2%	170.2K	-	170.2K	+100.00%
Sep 30, 2023	ALPHABET INC.	0.21%	175.87K	-	0	0
Sep 30, 2023	RAFFERTY ASSET MANAGEMENT, LLC	0.22%	186.62K	-	20.33K	+12.22%
Sep 30, 2023	HRT FINANCIAL LP	0.23%	193.29K	-	193.29K	+100.00%
Sep 30, 2023	BANK OF NEW YORK MELLON CORP	0.28%	232K	-	-2.78K	-1.18%

Insiders

Among the ALEC insiders holding of 9.94% of the stake in company, MCGUIRE TERRANCE, , holds the largest shares of 10.85M. POLARIS VENTURE MANAGEMENT CO. VI, L.L.C., 10 percent owner, is the second largest ALEC insider with ownership of 10.85M shares. ROSENTHAL ARNON, Chief Executive Officer, stands third with possession of 2.42M shares of that stake.

Insiders	Designation	Shares Held
MCGUIRE TERRANCE		10.85M
POLARIS VENTURE MANAGEMENT CO. VI, L.L.C.	10 percent owner	10.85M
ROSENTHAL ARNON	Chief Executive Officer	2.42M
KING ROBERT	Chief Development Officer	529.3K
KENKARE-MITRA SARA	President and Head of R&D	501.65K
BERKLEY NEIL LINDSAY	Chief Bus Ofcr & Interim CFO	374.31K
ROMANO GARY	Chief Medical Officer	332.98K
GRASSO MARC	Chief Financial Officer	296.07K
PAUL ROBERT	Chief Medical Officer	234.32K
WONG-SARAD GRACE	Principal Accounting Officer	122.98K
SULIMAN SHEHNAAZ	President and COO	102.6K
YAFFE KRISTINE	director	95.41K
YU CALVIN	Vice President, Finance	76.69K
HAMMOND PAULA	director	74.91K
SCHELLER RICHARD H	director	35K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Dec 05, 2025	WONG-SARAD GRACE	SALE	1.21	4.75K	5.75K	122.98K
Dec 03, 2025	ROSENTHAL ARNON	SALE	1.12	104.35K	116.83K	2.42M
Dec 03, 2025	WONG-SARAD GRACE	SALE	1.12	8.06K	9.02K	127.74K
Dec 03, 2025	BERKLEY NEIL LINDSAY	SALE	1.12	37.26K	41.72K	374.31K
Dec 03, 2025	KENKARE-MITRA SARA	SALE	1.12	41.69K	46.67K	501.65K
Sep 02, 2025	KENKARE-MITRA SARA	SALE	2.50	23.64K	59.02K	543.34K
Sep 02, 2025	WONG-SARAD GRACE	SALE	2.50	5.91K	14.76K	103.45K
Sep 02, 2025	BERKLEY NEIL LINDSAY	SALE	2.50	15.84K	39.55K	346.57K
Sep 02, 2025	ROSENTHAL ARNON	SALE	2.50	51.56K	128.74K	2.35M
Aug 26, 2025	HAMMOND PAULA	SALE	2.36	14K	33K	74.91K
Jun 20, 2025	YAFFE KRISTINE	SALE	1.44	1K	1.44K	95.41K
Jun 02, 2025	ROSENTHAL ARNON	SALE	1.34	52.09K	69.71K	2.41M
Jun 02, 2025	KENKARE-MITRA SARA	SALE	1.34	23.89K	31.97K	512.25K
Jun 02, 2025	GRASSO MARC	SALE	1.34	16.49K	22.07K	296.07K
Mar 03, 2025	ROMANO GARY	SALE	1.47	16.31K	23.93K	332.98K
Mar 03, 2025	GRASSO MARC	SALE	1.47	18.09K	26.55K	312.56K
Mar 03, 2025	ROSENTHAL ARNON	SALE	1.47	40.33K	59.18K	2.47M
Mar 03, 2025	KENKARE-MITRA SARA	SALE	1.47	29.07K	42.66K	536.14K
Dec 02, 2024	ROMANO GARY	SALE	2.52	14.89K	37.52K	349.28K
Dec 02, 2024	KENKARE-MITRA SARA	SALE	2.52	26.5K	66.76K	565.22K
Dec 02, 2024	ROSENTHAL ARNON	SALE	2.52	52.17K	131.44K	2.51M
Dec 02, 2024	GRASSO MARC	SALE	2.52	16.49K	41.54K	330.65K
Sep 03, 2024	GRASSO MARC	SALE	4.88	7.3K	35.62K	130.74K
Sep 03, 2024	ROSENTHAL ARNON	SALE	4.88	26.5K	129.39K	1.95M
Sep 03, 2024	KENKARE-MITRA SARA	SALE	4.88	13.93K	67.98K	291.72K
Sep 03, 2024	ROMANO GARY	SALE	4.88	8.48K	41.39K	179.8K
Aug 22, 2024	SCHELLER RICHARD H	SALE	5.16	44.25K	228.39K	35K
Aug 12, 2024	YAFFE KRISTINE	SALE	5.06	5K	25.31K	67.71K
Aug 12, 2024	HAMMOND PAULA	SALE	5.06	10.5K	53.18K	60.21K
Jun 03, 2024	ROSENTHAL ARNON	SALE	4.80	25.14K	120.62K	1.98M
Jun 03, 2024	ROMANO GARY	SALE	4.80	8.04K	38.58K	188.27K
Jun 03, 2024	GRASSO MARC	SALE	4.80	6.92K	33.21K	138.04K
Jun 03, 2024	KENKARE-MITRA SARA	SALE	4.80	13.21K	63.37K	305.64K
Mar 04, 2024	ROMANO GARY	SALE	6.92	6K	41.55K	196.31K
Mar 04, 2024	GRASSO MARC	SALE	6.92	5.72K	39.56K	144.96K
Mar 04, 2024	KENKARE-MITRA SARA	SALE	6.92	10.17K	70.39K	318.85K
Mar 04, 2024	ROSENTHAL ARNON	SALE	6.92	18.84K	130.39K	2M
Dec 04, 2023	KENKARE-MITRA SARA	SALE	5.56	12.52K	69.61K	329.02K
Dec 04, 2023	ROSENTHAL ARNON	SALE	5.56	23.83K	132.5K	2.02M
Dec 04, 2023	GRASSO MARC	SALE	5.56	4.57K	25.43K	150.67K
Dec 04, 2023	ROMANO GARY	SALE	5.56	5.04K	27.99K	202.31K
Sep 11, 2023	MCGUIRE TERRANCE	SALE	6.00	500K	3M	10.85M
Sep 11, 2023	POLARIS VENTURE MANAGEMENT CO. VI, L.L.C.	SALE	6.00	500K	3M	10.85M
Sep 05, 2023	ROSENTHAL ARNON	SALE	5.19	5.65K	29.33K	1.65M
Sep 05, 2023	GRASSO MARC	SALE	5.19	1.11K	5.79K	32.25K
Sep 05, 2023	ROMANO GARY	SALE	5.19	2.77K	14.39K	99.35K
Sep 05, 2023	KENKARE-MITRA SARA	SALE	5.19	6.21K	32.28K	177.94K
Jun 02, 2023	KENKARE-MITRA SARA	SALE	6.90	4.09K	28.25K	184.15K
Jun 02, 2023	GRASSO MARC	SALE	6.90	1.05K	7.25K	33.36K
Jun 02, 2023	ROMANO GARY	SALE	6.90	2.62K	18.07K	102.12K
Jun 02, 2023	ROSENTHAL ARNON	SALE	6.90	5.26K	36.28K	1.65M
Mar 17, 2023	ROSENTHAL ARNON	SALE	6.22	15.19K	94.43K	1.66M
Mar 02, 2023	ROSENTHAL ARNON	SALE	8.32	5.85K	48.65K	1.63M
Mar 02, 2023	GRASSO MARC	SALE	8.32	1.29K	10.74K	34.41K
Mar 02, 2023	KENKARE-MITRA SARA	SALE	8.32	10.12K	84.22K	188.24K
Mar 02, 2023	ROMANO GARY	SALE	8.32	3.24K	26.93K	104.74K
Dec 02, 2022	ROMANO GARY	SALE	8.71	2.15K	18.68K	107.98K
Sep 02, 2022	KING ROBERT	SALE	10.62	176	1.87K	529.3K
Sep 02, 2022	ROMANO GARY	SALE	10.62	2.18K	23.12K	90.07K
Jun 02, 2022	KING ROBERT	SALE	8.71	177	1.54K	529.47K
Mar 01, 2022	KING ROBERT	SALE	15.57	287	4.47K	528.4K
Dec 13, 2021	SULIMAN SHEHNAAZ	SALE	21.73	10.9K	236.8K	102.6K
Dec 10, 2021	SULIMAN SHEHNAAZ	SALE	22.33	8.87K	198.19K	102.6K
Dec 09, 2021	SULIMAN SHEHNAAZ	SALE	23.40	2.64K	61.86K	102.6K
Dec 08, 2021	SULIMAN SHEHNAAZ	SALE	23.01	38.49K	885.69K	102.6K
Dec 01, 2021	KING ROBERT	SALE	20.09	250	5.02K	528.69K
Nov 11, 2021	ROSENTHAL ARNON	SALE	25.00	55K	1.38M	1.97M
Nov 10, 2021	ROSENTHAL ARNON	SALE	25.00	55K	1.38M	2.03M
Nov 09, 2021	ROSENTHAL ARNON	SALE	25.00	15K	375K	652.5K
Nov 08, 2021	ROSENTHAL ARNON	SALE	25.00	15K	375K	667.5K
Nov 05, 2021	ROSENTHAL ARNON	SALE	25.00	15K	375K	682.5K
Nov 04, 2021	ROSENTHAL ARNON	SALE	25.00	15K	375K	697.5K
Sep 23, 2021	ROSENTHAL ARNON	SALE	25.10	9.63K	241.57K	2.3M
Sep 22, 2021	ROSENTHAL ARNON	SALE	26.10	5.28K	137.89K	2.31M
Sep 21, 2021	ROSENTHAL ARNON	SALE	26.56	8.46K	224.74K	2.41M
Sep 20, 2021	ROSENTHAL ARNON	SALE	26.33	8.05K	211.85K	2.51M
Aug 09, 2021	PAUL ROBERT	SALE	27.79	300	8.34K	234.32K
Aug 05, 2021	SCHELLER RICHARD H	SALE	28.30	3.39K	96K	0
Jul 07, 2021	PAUL ROBERT	SALE	39.32	17.15K	674.22K	234.32K
Jul 06, 2021	PAUL ROBERT	SALE	40.01	1.1K	44.02K	234.32K
Jul 06, 2021	YU CALVIN	SALE	34.65	3.33K	115.52K	76.69K
Jul 02, 2021	YU CALVIN	SALE	40.02	20K	800.32K	76.69K
Jul 02, 2021	SCHELLER RICHARD H	SALE	31.14	9.98K	310.81K	0
Jul 02, 2021	PAUL ROBERT	SALE	31.14	30K	934.2K	234.32K
Jul 02, 2021	KING ROBERT	SALE	31.14	60K	1.87M	522.32K
Jul 01, 2021	PAUL ROBERT	SALE	22.23	26.73K	594.12K	246.99K
Jun 16, 2021	PAUL ROBERT	SALE	22.18	4.6K	102.05K	273.72K
Jun 15, 2021	PAUL ROBERT	SALE	22.07	30K	661.95K	273.72K
Jun 08, 2021	PAUL ROBERT	SALE	20.83	800	16.66K	273.72K
Jun 02, 2021	YU CALVIN	SALE	17.77	1.84K	32.77K	126.69K
May 21, 2021	PAUL ROBERT	SALE	18.14	14.98K	271.68K	273.72K
May 18, 2021	PAUL ROBERT	SALE	18.04	4.2K	75.79K	273.72K
Apr 07, 2021	PAUL ROBERT	SALE	19.83	45	892.35	213.72K
Mar 23, 2021	PAUL ROBERT	SALE	22.21	13.8K	306.5K	213.72K
Mar 22, 2021	PAUL ROBERT	SALE	23.55	5.51K	129.77K	213.72K
Mar 09, 2021	PAUL ROBERT	SALE	18.12	19.18K	347.4K	213.72K
Feb 09, 2021	PAUL ROBERT	SALE	20.81	19.18K	399.05K	213.72K
Jan 26, 2021	PAUL ROBERT	SALE	18.00	27.31K	491.54K	213.72K
Jan 25, 2021	PAUL ROBERT	SALE	18.01	30K	540.23K	213.72K
Jan 20, 2021	PAUL ROBERT	SALE	18.00	8.57K	154.21K	213.72K
Jan 19, 2021	PAUL ROBERT	SALE	18.12	30K	543.55K	213.72K
Jul 15, 2020	PAUL ROBERT	SALE	23.58	378	8.91K	213.72K
Jun 23, 2020	POLARIS VENTURE MANAGEMENT CO. VI, L.L.C.	SALE	31.54	4.38K	138.06K	12.85M
Jun 23, 2020	MCGUIRE TERRANCE	SALE	31.54	4.38K	138.06K	12.85M
Jun 15, 2020	PAUL ROBERT	SALE	29.90	3.91K	116.88K	223.72K
Jun 03, 2020	YU CALVIN	SALE	31.04	1.04K	32.37K	110.99K
May 15, 2020	PAUL ROBERT	SALE	26.15	1.9K	49.69K	241.82K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES307.06K10

NET SHARES-307.06K10

SHARES HELD6.97M10

% NET SHARES-104.41%0%

Frequently Asked Questions

Stock Outstanding Shares

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares5.95

Short Percent Of Float7.36

Shares Outstanding109.15M

Shares Float78.19M

Shares Short6.49M

Short Ratio5.55

7.36%

Short % of Float

5.95%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

9.94% Percentage of Shares held by All Insiders

82.14% Percentage of Shares held by All Institutions

91.2% Percentage of Float held by Institutions

203

Number of Institutions Holding Shares

Institutional Ownership

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.52%	524.08K	1.55M	65.21K	+14.21%
Sep 30, 2025	MEDICI CAPITAL LLC	0.48%	481.97K	1.43M	314.78K	+188.28%
Sep 30, 2025	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.11%	115K	340.4K	0	0
Sep 30, 2025	NUVEEN, LLC	0.13%	133.25K	394.41K	-22.37K	-14.37%
Sep 30, 2025	DIADEMA PARTNERS LP	0.14%	136.02K	402.63K	-130K	-48.87%
Sep 30, 2025	JPMORGAN CHASE & CO	0.14%	136.39K	403.7K	90.89K	+199.81%
Sep 30, 2025	RTW INVESTMENTS, LP	6.96%	6.99M	20.69M	6.99M	+100.00%
Sep 30, 2025	TWO SIGMA ADVISERS, LP	0.52%	517.4K	1.53M	140.4K	+37.24%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.85%	1.86M	5.51M	-120.81K	-6.10%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.18%	2.19M	6.47M	-2.69M	-55.18%
Sep 30, 2025	ACADIAN ASSET MANAGEMENT LLC	2.36%	2.37M	7.02M	202.6K	+9.33%
Sep 30, 2025	MERCK & CO., INC.	3.53%	3.55M	10.5M	0	0
Sep 30, 2025	VANGUARD GROUP INC	6.01%	6.03M	17.86M	46.96K	+0.78%
Sep 30, 2025	BLACKROCK, INC.	7.17%	7.2M	21.31M	-775.61K	-9.73%
Sep 30, 2025	FMR LLC	15.13%	15.18M	44.94M	182.96K	+1.22%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.27%	273.74K	810.26K	-378K	-58.00%
Sep 30, 2025	AMERIPRISE FINANCIAL INC	0.27%	274.04K	811.16K	259.91K	+1,838.75%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.69%	689.52K	2.04M	41.87K	+6.47%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.31%	308.66K	913.63K	104.86K	+51.45%
Sep 30, 2025	LOGOS GLOBAL MANAGEMENT LP	0.5%	500K	1.48M	500K	+100.00%
Sep 30, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.22%	216.57K	641.06K	-97K	-30.93%
Sep 30, 2025	MACKENZIE FINANCIAL CORP	0.28%	283.71K	839.79K	9.27K	+3.38%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.29%	295.85K	876.02K	-87.49K	-22.82%
Sep 30, 2025	PANAGORA ASSET MANAGEMENT INC	0.74%	741.29K	2.19M	224.61K	+43.47%
Sep 30, 2025	IKARIAN CAPITAL, LLC	0.76%	760K	2.25M	-140K	-15.56%
Sep 30, 2025	MARSHALL WACE, LLP	0.15%	151.64K	448.86K	151.64K	+100.00%
Sep 30, 2025	NEW LEAF VENTURE PARTNERS, L.L.C.	0.34%	339.57K	1.01M	0	0
Sep 30, 2025	JANE STREET GROUP, LLC	0.35%	350.23K	1.04M	326.28K	+1,362.22%
Sep 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.44%	438.09K	1.3M	31.47K	+7.74%
Sep 30, 2025	CITADEL ADVISORS LLC	0.47%	471.58K	1.4M	-80.24K	-14.54%
Sep 30, 2025	BARCLAYS PLC	0.87%	873.38K	2.59M	703.58K	+414.37%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.95%	949.15K	2.81M	-305.7K	-24.36%
Sep 30, 2025	VESTAL POINT CAPITAL, LP	0.98%	980K	2.9M	3.01K	+0.31%
Sep 30, 2025	683 CAPITAL MANAGEMENT, LLC	1%	1M	2.96M	1M	+100.00%
Sep 30, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	1.23%	1.23M	3.64M	-91.91K	-6.95%
Sep 30, 2025	UBS GROUP AG	0.23%	230.5K	682.28K	188.61K	+450.21%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.25%	246.28K	729K	-97.63K	-28.39%
Sep 30, 2025	MORGAN STANLEY	0.43%	434.17K	1.29M	-172.38K	-28.42%
Sep 30, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.8%	798.35K	2.36M	-114.58K	-12.55%
Sep 30, 2025	5AM VENTURE MANAGEMENT, LLC	0.99%	995.84K	2.95M	0	0
Sep 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.05%	1.06M	3.12M	0	0
Sep 30, 2025	ROYAL BANK OF CANADA	0.63%	628.65K	1.86M	261.46K	+71.21%
Sep 30, 2025	D. E. SHAW & CO., INC.	0.97%	978.2K	2.9M	444K	+83.12%
Sep 30, 2025	EUCLIDEAN CAPITAL LLC	1.3%	1.31M	3.87M	0	0
Sep 30, 2025	EVERSEPT PARTNERS, LP	1.48%	1.49M	4.41M	-497.35K	-25.04%
Sep 30, 2025	PROSHARE ADVISORS LLC	0.02%	15.43K	45.68K	-4.65K	-23.14%
Sep 30, 2025	DLK INVESTMENT MANAGEMENT, LLC	0.02%	15.5K	45.88K	0	0
Sep 30, 2025	SEI INVESTMENTS CO	0.02%	16.88K	49.98K	0	0
Sep 30, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	17.74K	52.51K	-2.34K	-11.66%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.02%	18.27K	54.08K	6.64K	+57.03%
Sep 30, 2025	ERSTE ASSET MANAGEMENT GMBH	0.02%	19K	57.95K	0	0
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.02%	20.48K	60.62K	20.48K	+100.00%
Sep 30, 2025	GROUP ONE TRADING, L.P.	0.02%	22.32K	66.07M	22.32K	+100.00%
Sep 30, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.02%	23.43K	69.34K	6.42K	+37.77%
Sep 30, 2025	APOLLON WEALTH MANAGEMENT, LLC	0.02%	25K	74K	0	0
Sep 30, 2025	CWM, LLC	0.03%	25.17K	75K	-728	-2.81%
Sep 30, 2025	VONTOBEL HOLDING LTD.	0.03%	26K	76.96K	-12K	-31.58%
Sep 30, 2025	CERITY PARTNERS LLC	0.03%	26.81K	79.35K	3.07K	+12.94%
Sep 30, 2025	PRUDENTIAL FINANCIAL INC	0.03%	28.02K	82.95K	6.7K	+31.42%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	28.82K	85.31K	28.82K	+100.00%
Sep 30, 2025	PERSISTENT ASSET PARTNERS LTD	0.03%	31.24K	92.47K	-29.86K	-48.87%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	33.43K	98.95K	-6.49K	-16.25%
Sep 30, 2025	HSBC HOLDINGS PLC	0.05%	48.67K	139.67K	-3.03K	-5.87%
Sep 30, 2025	BANK OF MONTREAL /CAN/	0.05%	52.38K	155.05K	0	0
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.05%	52.43K	155.18K	1.82K	+3.60%
Sep 30, 2025	CITIGROUP INC	0.05%	53.94K	159.66K	4.48K	+9.05%
Sep 30, 2025	VANGUARD PERSONALIZED INDEXING MANAGEMENT, LLC	0.06%	58.32K	172.63K	6.23K	+11.95%
Sep 30, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.09%	91.24K	270.06K	-60.66K	-39.94%
Sep 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.1%	100K	303K	0	0
Sep 30, 2025	SIMPLEX TRADING, LLC	0.1%	100.94K	298K	100.94K	+100.00%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.1%	104.82K	310.28K	4.46K	+4.44%
Sep 30, 2025	STRS OHIO	0.11%	110.4K	326.78K	0	0
Sep 30, 2025	RHUMBLINE ADVISERS	0.11%	114.27K	338.23K	-12.3K	-9.72%
Sep 30, 2025	ALPHABET INC.	0.18%	175.87K	520.56K	0	0
Sep 30, 2025	INVESCO LTD.	0.19%	192.31K	569.24K	16.51K	+9.39%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.22%	224.48K	664.47K	-44.39K	-16.51%
Sep 30, 2025	STATE STREET CORP	1.73%	1.73M	5.13M	24.78K	+1.45%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	0.61%	609.91K	1.81M	235.43K	+62.87%
Sep 30, 2025	DEUTSCHE BANK AG\	1.06%	1.07M	3.16M	78.47K	+7.93%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	1.15%	1.16M	3.42M	744.22K	+181.16%
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.31%	307.18K	909.25K	85.04K	+38.28%
Sep 30, 2025	NORTHERN TRUST CORP	0.63%	633.71K	1.88M	-24.45K	-3.72%
Jun 30, 2025	JASPER RIDGE PARTNERS, L.P.	0.03%	30.63K	42.89K	0	0
Jun 30, 2025	VONTOBEL HOLDING LTD.	0.04%	38K	53.2K	8K	+26.67%
Jun 30, 2025	CITADEL ADVISORS LLC	0.55%	551.82K	772.55K	546.38K	+10,047.48%
Jun 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.04%	39.92K	55.88K	-20.84K	-34.30%
Jun 30, 2025	TUDOR INVESTMENT CORP ET AL	0.04%	40.8K	57.11K	-1	0.00%
Jun 30, 2025	ALGERT GLOBAL LLC	0.04%	44.46K	62K	0	0
Jun 30, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0.05%	46.29K	64.8K	-28.36K	-37.99%
Jun 30, 2025	UTAH RETIREMENT SYSTEMS	0.05%	51.43K	72K	0	0
Jun 30, 2025	VANGUARD PERSONALIZED INDEXING MANAGEMENT, LLC	0.05%	52.1K	72.93K	17.17K	+49.16%
Jun 30, 2025	VELAN CAPITAL INVESTMENT MANAGEMENT LP	0.05%	55K	77K	0	0
Jun 30, 2025	IEQ CAPITAL, LLC	0.06%	59K	82.6K	-21.41K	-26.62%
Jun 30, 2025	SPEARS ABACUS ADVISORS LLC	0.06%	61.51K	86.12K	-100	-0.16%
Jun 30, 2025	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.07%	70.78K	99.09K	-67.13K	-48.68%
Jun 30, 2025	XTX TOPCO LTD	0.07%	73.34K	102.67K	40.77K	+125.16%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.09%	92.94K	130.12M	10.84K	+13.20%
Jun 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.1%	100K	148K	0	0
Jun 30, 2025	IKARIAN CAPITAL, LLC	0.9%	900K	1.26M	-50K	-5.26%
Jun 30, 2025	STATE STREET CORP	1.7%	1.71M	2.39M	69.64K	+4.25%
Jun 30, 2025	DLK INVESTMENT MANAGEMENT, LLC	0.02%	15.5K	21.7K	4K	+34.78%
Jun 30, 2025	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0%	3.86K	5.41K	547	+16.50%
Jun 30, 2025	TEXAS YALE CAPITAL CORP.	0.01%	10K	14K	0	0
Jun 30, 2025	SHELL ASSET MANAGEMENT CO	0.01%	13.89K	19K	-6.74K	-32.68%
Jun 30, 2025	ACADIAN ASSET MANAGEMENT LLC	2.16%	2.17M	3.03M	729.73K	+50.65%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.65%	647.65K	906.71K	22.92K	+3.67%
Jun 30, 2025	MORGAN STANLEY	0.6%	606.55K	849.17K	259.85K	+74.95%
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	1.25%	1.25M	1.76M	221K	+21.38%
Jun 30, 2025	EUCLIDEAN CAPITAL LLC	1.3%	1.31M	1.83M	0	0
Jun 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	1.72%	1.72M	2.41M	1.34M	+353.17%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.97%	1.98M	2.78M	19.97K	+1.02%
Jun 30, 2025	EVERSEPT PARTNERS, LP	1.98%	1.99M	2.78M	1.37M	+221.67%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	4.86%	4.88M	6.83M	4.2M	+620.86%
Jun 30, 2025	FMR LLC	14.94%	15M	21M	608.65K	+4.23%
Jun 30, 2025	MERCK & CO., INC.	3.53%	3.55M	4.96M	0	0
Jun 30, 2025	VANGUARD GROUP INC	5.97%	5.99M	8.38M	-65.34K	-1.08%
Jun 30, 2025	BLACKROCK, INC.	7.94%	7.97M	11.16M	-306.12K	-3.70%
Jun 30, 2025	GSA CAPITAL PARTNERS LLP	0.15%	150.67K	211K	150.67K	+100.00%
Jun 30, 2025	DIVERSIFIED TRUST CO	0.01%	14.1K	19.74K	0	0
Jun 30, 2025	WALLEYE CAPITAL LLC	0.27%	266.2K	372.69K	-39.4K	-12.89%
Jun 30, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.91%	912.93K	1.28M	0	0
Jun 30, 2025	DEUTSCHE BANK AG\	0.99%	989.75K	1.39M	-111.8K	-10.15%
Jun 30, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	1.32%	1.32M	1.85M	-11.15K	-0.84%
Jun 30, 2025	D. E. SHAW & CO., INC.	0.53%	534.2K	747.88K	64.9K	+13.83%
Jun 30, 2025	TD ASSET MANAGEMENT INC	0.65%	651.74K	912.43K	540K	+483.27%
Jun 30, 2025	SIO CAPITAL MANAGEMENT, LLC	0.84%	845.53K	1.18M	8.37K	+1.00%
Jun 30, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.15%	151.9K	212.65K	7.6K	+5.27%
Jun 30, 2025	NUVEEN, LLC	0.16%	155.61K	217.86K	17.43K	+12.62%
Jun 30, 2025	MEDICI CAPITAL LLC	0.17%	167.19K	234.07K	0	0
Jun 30, 2025	BARCLAYS PLC	0.17%	169.8K	238K	44.71K	+35.74%
Jun 30, 2025	INVESCO LTD.	0.18%	175.8K	246.12K	27.23K	+18.32%
Jun 30, 2025	DIADEMA PARTNERS LP	0.27%	266.02K	372.43K	-190.52K	-41.73%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.27%	268.87K	376.42K	19.38K	+7.77%
Jun 30, 2025	ALPHABET INC.	0.18%	175.87K	246.21K	0	0
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.2%	203.8K	285.32K	-49.32K	-19.49%
Jun 30, 2025	TWO SIGMA INVESTMENTS, LP	0.22%	222.14K	311K	7.71K	+3.60%
Jun 30, 2025	STATE OF WYOMING	0.22%	223.09K	312.33K	26.28K	+13.35%
Jun 30, 2025		0.16%	155.61K	217.86K	17.43K	+12.62%
Jun 30, 2025	MACKENZIE FINANCIAL CORP	0.27%	274.44K	384.22K	274.44K	+100.00%
Jun 30, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.31%	313.58K	439.01K	189.69K	+153.11%
Jun 30, 2025	NEW LEAF VENTURE PARTNERS, L.L.C.	0.34%	339.57K	475.4K	0	0
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.34%	343.91K	481.47K	5.93K	+1.75%
Jun 30, 2025	ROYAL BANK OF CANADA	0.37%	367.19K	513K	362.4K	+7,560.92%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.37%	374.48K	524.27K	62.33K	+19.97%
Jun 30, 2025	TWO SIGMA ADVISERS, LP	0.38%	377K	527.8K	-15.9K	-4.05%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.38%	383.33K	536.94K	-106K	-21.66%
Jun 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.41%	406.62K	569.27K	-85.97K	-17.45%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.41%	410.8K	575.12K	145.99K	+55.13%
Jun 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.46%	458.86K	642.41K	184.5K	+67.25%
Jun 30, 2025	PANAGORA ASSET MANAGEMENT INC	0.51%	516.68K	723.35K	150.14K	+40.96%
Jun 30, 2025	NORTHERN TRUST CORP	0.66%	658.16K	921.43K	-39.07K	-5.60%
Jun 30, 2025	VESTAL POINT CAPITAL, LP	0.97%	976.99K	1.37M	472.45K	+93.64%
Jun 30, 2025	5AM VENTURE MANAGEMENT, LLC	0.99%	995.84K	1.39M	0	0
Jun 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.05%	1.06M	1.48M	0	0
Jun 30, 2025	FNY INVESTMENT ADVISERS, LLC	0.02%	20K	28K	10K	+100.00%
Jun 30, 2025	GRAHAM CAPITAL MANAGEMENT, L.P.	0.02%	21.37K	29.92K	-19.73K	-48.00%
Jun 30, 2025	CERITY PARTNERS LLC	0.02%	23.74K	33.23K	-17.83K	-42.89%
Jun 30, 2025	APOLLON WEALTH MANAGEMENT, LLC	0.02%	25K	35K	0	0
Jun 30, 2025	BLACKSTONE INC.	0.03%	25.72K	36K	0	0
Mar 31, 2025	SIO CAPITAL MANAGEMENT, LLC	0.84%	837.16K	1.03M	221.53K	+35.98%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.63%	624.73K	768.42K	-18.73K	-2.91%
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.38%	380.33K	467.81K	12K	+3.26%
Mar 31, 2025	ALPHABET INC.	0.18%	175.87K	216.32K	0	0
Mar 31, 2025	FMR LLC	14.48%	14.39M	17.7M	-299.63K	-2.04%
Mar 31, 2025	BLACKROCK, INC.	8.33%	8.28M	10.18M	-857.05K	-9.38%
Mar 31, 2025		0.14%	138.18K	646.04K	138.18K	+100.00%
Mar 31, 2025	DEUTSCHE BANK AG\	1.11%	1.1M	1.35M	-4.74K	-0.43%
Mar 31, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.06%	1.06M	1.3M	-11.77K	-1.10%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	1.04%	1.03M	1.27M	118.12K	+12.90%
Mar 31, 2025	5AM VENTURE MANAGEMENT, LLC	1%	995.84K	1.22M	0	0
Mar 31, 2025	AQR CAPITAL MANAGEMENT LLC	0.5%	492.59K	605.89K	-70.34K	-12.50%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.49%	489.33K	602.09K	-392.79K	-44.53%
Mar 31, 2025	D. E. SHAW & CO., INC.	0.47%	469.3K	577.24K	100.32K	+27.19%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.22%	214.43K	263.74K	-193.56K	-47.44%
Mar 31, 2025	STATE OF WYOMING	0.2%	196.81K	242.08K	196.81K	+100.00%
Mar 31, 2025	MEDICI CAPITAL LLC	0.17%	167.19K	205.65K	0	0
Mar 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.16%	157.31K	193.49K	-8.28K	-5.00%
Mar 31, 2025	INVESCO LTD.	0.15%	148.58K	182.75K	100.59K	+209.63%
Mar 31, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.15%	144.3K	177.48K	53.56K	+59.03%
Mar 31, 2025	TWO SIGMA ADVISERS, LP	0.4%	392.9K	483.27K	-37K	-8.61%
Mar 31, 2025	PANAGORA ASSET MANAGEMENT INC	0.37%	366.55K	450.85K	-2.53K	-0.69%
Mar 31, 2025	MORGAN STANLEY	0.35%	346.71K	426.45K	-303.83K	-46.70%
Mar 31, 2025	NEW LEAF VENTURE PARTNERS, L.L.C.	0.34%	339.57K	417.67K	0	0
Mar 31, 2025	JANE STREET GROUP, LLC	0.26%	256.55K	315.56K	11.62K	+4.74%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.25%	253.12K	311.34K	53.36K	+26.71%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.25%	249.49K	306.88K	18.77K	+8.13%
Mar 31, 2025	VANGUARD GROUP INC	6.09%	6.05M	7.45M	436.66K	+7.77%
Mar 31, 2025	MERCK & CO., INC.	3.57%	3.55M	4.36M	0	0
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.97%	1.96M	2.41M	47.85K	+2.50%
Mar 31, 2025	STATE STREET CORP	1.65%	1.64M	2.02M	-209.03K	-11.30%
Mar 31, 2025	JPMORGAN CHASE & CO	1.5%	1.49M	1.83M	-156.42K	-9.52%
Mar 31, 2025	ACADIAN ASSET MANAGEMENT LLC	1.45%	1.44M	1.77M	410.21K	+39.81%
Mar 31, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	1.34%	1.33M	1.64M	274.34K	+25.89%
Mar 31, 2025	EUCLIDEAN CAPITAL LLC	1.32%	1.31M	1.61M	0	0
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.27%	264.82K	325.72K	190.13K	+254.58%
Mar 31, 2025	ALMITAS CAPITAL LLC	0.32%	321.57K	395.53K	36.72K	+12.89%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.31%	312.15K	383.94K	-96.93K	-23.70%
Mar 31, 2025	WALLEYE CAPITAL LLC	0.31%	305.6K	375.89K	158.92K	+108.35%
Mar 31, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.28%	274.36K	337.46K	-19.8K	-6.73%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.34%	337.98K	415.72K	19.33K	+6.07%
Mar 31, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.92%	912.93K	1.12M	0	0
Mar 31, 2025	FRANKLIN RESOURCES INC	0.84%	834.27K	1.03M	-96.26K	-10.35%
Mar 31, 2025	NORTHERN TRUST CORP	0.7%	697.23K	857.59K	-62.65K	-8.24%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.68%	676.31K	832K	-69.78K	-9.35%
Mar 31, 2025	EVERSEPT PARTNERS, LP	0.62%	617.42K	759.42K	417.32K	+208.56%
Mar 31, 2025	VESTAL POINT CAPITAL, LP	0.51%	504.54K	620.58K	504.54K	+100.00%
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	9.75%	9.7M	11.93M	0	0
Mar 31, 2025	IKARIAN CAPITAL, LLC	0.96%	950K	1.17M	0	0
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.4%	339.88K	2.05M	-92.81K	-21.45%
Mar 31, 2024	CITIGROUP INC	0.29%	240.98K	1.45M	158.43K	+191.94%
Mar 31, 2024	WALLEYE CAPITAL LLC	0.3%	252.81K	1.52M	-9.32K	-3.55%
Mar 31, 2024	ALYESKA INVESTMENT GROUP, L.P.	0.3%	256.18K	1.54M	256.18K	+100.00%
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	0.33%	275.63K	1.66M	84.72K	+44.38%
Mar 31, 2024	FMR LLC	17.02%	14.36M	86.46M	1.74M	+13.80%
Mar 31, 2024	VANGUARD GROUP INC	5.82%	4.91M	29.57M	526.04K	+11.99%
Mar 31, 2024	ECOR1 CAPITAL, LLC	4.81%	4.06M	24.42M	0	0
Mar 31, 2024	VERITION FUND MANAGEMENT LLC	1.48%	1.25M	7.54M	1.11M	+755.63%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.8%	675.48K	4.07M	103.5K	+18.09%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.8%	674.79K	4.06M	175.26K	+35.09%
Mar 31, 2024	SPHERA FUNDS MANAGEMENT LTD.	0.66%	560K	3.37M	560K	+100.00%
Mar 31, 2024	TWO SIGMA ADVISERS, LP	0.64%	539.5K	3.25M	146.4K	+37.24%
Mar 31, 2024	EVERSEPT PARTNERS, LP	0.64%	536.17K	3.23M	536.17K	+100.00%
Mar 31, 2024	ACADIAN ASSET MANAGEMENT LLC	0.53%	444.65K	2.68M	301.94K	+211.57%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.43%	364.63K	2.2M	172.08K	+89.37%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.27%	230.31K	1.39M	21.26K	+10.17%
Mar 31, 2024	UBS GROUP AG	0.27%	229.49K	1.38M	50.79K	+28.43%
Mar 31, 2024	PANAGORA ASSET MANAGEMENT INC	0.26%	219.7K	1.32M	-16.94K	-7.16%
Mar 31, 2024	AQR CAPITAL MANAGEMENT LLC	0.23%	190.21K	1.15M	124.54K	+189.66%
Mar 31, 2024	WOODLINE PARTNERS LP	0.23%	190K	1.14M	190K	+100.00%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.38%	319.27K	1.92M	33.37K	+11.67%
Mar 31, 2024	STIFEL FINANCIAL CORP	0.17%	146.69K	883.07K	929	+0.64%
Mar 31, 2024	ALPHABET INC.	0.21%	175.87K	1.06M	0	0
Mar 31, 2024	MARSHALL WACE, LLP	0.21%	177.28K	1.07M	177.28K	+100.00%
Mar 31, 2024	MEDICI CAPITAL LLC	0.22%	185.93K	1.12M	-6.82K	-3.54%
Mar 31, 2024	NORDEA INVESTMENT MANAGEMENT AB	0.22%	188.77K	1.16M	-1.52K	-0.80%
Mar 31, 2024	BAILLIE GIFFORD & CO	0.38%	322.83K	1.94M	-23.1K	-6.68%
Mar 31, 2024	D. E. SHAW & CO., INC.	0.39%	329.63K	1.98M	145.48K	+79.00%
Mar 31, 2024	NEW LEAF VENTURE PARTNERS, L.L.C.	0.4%	339.57K	2.04M	0	0
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.42%	353.65K	2.13M	-86.66K	-19.68%
Mar 31, 2024	NORTHERN TRUST CORP	0.79%	670.22K	4.03M	55.67K	+9.06%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.86%	725.69K	4.37M	233.4K	+47.41%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	1%	845.96K	5.09M	81.57K	+10.67%
Mar 31, 2024	PRICE T ROWE ASSOCIATES INC /MD/	1.06%	890.49K	5.36M	-311.06K	-25.89%
Mar 31, 2024	DAFNA CAPITAL MANAGEMENT LLC	1.08%	912.93K	5.5M	303.02K	+49.68%
Mar 31, 2024	JACOBS LEVY EQUITY MANAGEMENT, INC	1.09%	922.8K	5.56M	128.52K	+16.18%
Mar 31, 2024	FRANKLIN RESOURCES INC	1.14%	959.52K	5.78M	0	0
Mar 31, 2024	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.27%	1.07M	6.46M	5.04K	+0.47%
Mar 31, 2024	EUCLIDEAN CAPITAL LLC	1.55%	1.31M	7.87M	0	0
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	1.87%	1.58M	9.49M	193.98K	+14.04%
Mar 31, 2024	JUPITER ASSET MANAGEMENT LTD	0.28%	232.22K	1.4M	0	0
Mar 31, 2024	DEUTSCHE BANK AG\	3.13%	2.64M	15.91M	580.77K	+28.16%
Mar 31, 2024	MORGAN STANLEY	3.92%	3.3M	19.9M	-1.35M	-28.93%
Mar 31, 2024	DEEP TRACK CAPITAL, LP	4.47%	3.77M	22.69M	3.77M	+100.00%
Mar 31, 2024	STATE STREET CORP	4.64%	3.92M	23.57M	797.64K	+25.59%
Mar 31, 2024	TREXQUANT INVESTMENT LP	0.05%	42.44K	255.51K	-2.13K	-4.77%
Mar 31, 2024	PROFUND ADVISORS LLC	0.05%	43.32K	260.8M	11.66K	+36.80%
Mar 31, 2024	BNP PARIBAS ARBITRAGE, SNC	0.05%	43.93K	264.44K	-51.03K	-53.74%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.06%	48.83K	293.93K	48.83K	+100.00%
Mar 31, 2024	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.06%	52.64K	325.62K	-8.6K	-14.04%
Mar 31, 2024	STATE OF WISCONSIN INVESTMENT BOARD	0.07%	55.02K	331.19K	-74.02K	-57.36%
Mar 31, 2024	LOS ANGELES CAPITAL MANAGEMENT LLC	0.07%	58.76K	353.71K	0	0
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.07%	58.86K	354.34M	-781	-1.31%
Mar 31, 2024	NEW YORK LIFE INVESTMENT MANAGEMENT LLC	0.07%	59.83K	360.17K	59.83K	+100.00%
Mar 31, 2024	GSA CAPITAL PARTNERS LLP	0.08%	63.58K	383K	63.58K	+100.00%
Mar 31, 2024	FEDERATED HERMES, INC.	0.08%	65.83K	396.29K	1.31K	+2.02%
Mar 31, 2024	SPEARS ABACUS ADVISORS LLC	0.08%	66.18K	398.39K	66.18K	+100.00%
Mar 31, 2024	ALPS ADVISORS INC	0.08%	67.53K	406.54K	10.74K	+18.91%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.08%	71.43K	430K	-1.15K	-1.59%
Mar 31, 2024	RUSSELL INVESTMENTS GROUP, LTD.	0.09%	78.35K	471.65K	7.07K	+9.91%
Mar 31, 2024	CREDIT SUISSE AG/	0.11%	90.72K	546.1K	5.42K	+6.35%
Mar 31, 2024	STRS OHIO	0.11%	91.2K	549K	18K	+24.59%
Mar 31, 2024	RHUMBLINE ADVISERS	0.11%	91.53K	550.97K	3.93K	+4.48%
Mar 31, 2024	DEKABANK DEUTSCHE GIROZENTRALE	0.12%	100K	605K	0	0
Mar 31, 2024	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.13%	109.13K	656.96K	87.85K	+412.83%
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.13%	111.74K	672.66M	0	0
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.14%	117.99K	710.32K	0	0
Mar 31, 2024	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.15%	126.16K	759.51K	126.16K	+100.00%
Mar 31, 2024	VICTORY CAPITAL MANAGEMENT INC	0.15%	129.14K	777.42K	3.75K	+2.99%
Mar 31, 2024	SWISS NATIONAL BANK	0.16%	131.9K	794.04K	8K	+6.46%
Mar 31, 2024	POINT72 ASSET MANAGEMENT, L.P.	0.82%	695.3K	4.19M	556.3K	+400.22%
Mar 31, 2024	JPMORGAN CHASE & CO	2.03%	1.72M	10.33M	-148.23K	-7.95%
Mar 31, 2024	BRAIDWELL LP	2.82%	2.38M	14.33M	-943.6K	-28.39%
Mar 31, 2024	BLACKROCK INC.	10.05%	8.48M	51.07M	415.01K	+5.14%
Dec 31, 2023	BLACKROCK INC.	9.61%	8.07M	64.39M	337.58K	+4.37%
Dec 31, 2023	SWISS NATIONAL BANK	0.15%	123.9K	988.72K	-11.7K	-8.63%
Dec 31, 2023	VICTORY CAPITAL MANAGEMENT INC	0.15%	125.39K	1M	-9.33K	-6.92%
Dec 31, 2023	STATE OF WISCONSIN INVESTMENT BOARD	0.15%	129.03K	1.03M	-18.71K	-12.66%
Dec 31, 2023	POINT72 ASSET MANAGEMENT, L.P.	0.17%	139K	1.11M	-599.78K	-81.19%
Dec 31, 2023	FMR LLC	15.04%	12.62M	100.71M	448.36K	+3.68%
Dec 31, 2023	ACADIAN ASSET MANAGEMENT LLC	0.17%	142.71K	1.14M	-10.56K	-6.89%
Dec 31, 2023	STIFEL FINANCIAL CORP	0.17%	145.76K	1.16M	119.61K	+457.40%
Dec 31, 2023	VERITION FUND MANAGEMENT LLC	0.17%	146.45K	1.17M	-20.56K	-12.31%
Dec 31, 2023	CUBIST SYSTEMATIC STRATEGIES, LLC	0.19%	162.83K	1.3M	153.21K	+1,593.14%
Dec 31, 2023	ALPHABET INC.	0.21%	175.87K	1.4M	0	0
Dec 31, 2023	UBS GROUP AG	0.21%	178.69K	1.43M	99.01K	+124.26%
Dec 31, 2023	D. E. SHAW & CO., INC.	0.22%	184.15K	1.47M	65.13K	+54.72%
Dec 31, 2023	NORDEA INVESTMENT MANAGEMENT AB	0.23%	190.29K	1.5M	-12.42K	-6.13%
Dec 31, 2023	RAFFERTY ASSET MANAGEMENT, LLC	0.23%	190.91K	1.52M	4.29K	+2.30%
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	0.23%	192.55K	1.54M	90.12K	+87.98%
Dec 31, 2023	MEDICI CAPITAL LLC	0.23%	192.75K	1.54M	133.09K	+223.11%
Dec 31, 2023	BARCLAYS PLC	0.23%	193.23K	1.54M	54.4K	+39.19%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.25%	209.05K	1.67M	-22.94K	-9.89%
Dec 31, 2023	JUPITER ASSET MANAGEMENT LTD	0.28%	232.22K	1.85M	0	0
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	0.28%	235.64K	1.88M	-121.13K	-33.95%
Dec 31, 2023	PANAGORA ASSET MANAGEMENT INC	0.28%	236.65K	1.89M	-56.89K	-19.38%
Dec 31, 2023	HRT FINANCIAL LP	0.28%	239.12K	1.91M	45.82K	+23.71%
Dec 31, 2023	CAMPBELL & CO INVESTMENT ADVISER LLC	0.29%	240.63K	1.92M	240.63K	+100.00%
Dec 31, 2023	WALLEYE CAPITAL LLC	0.31%	262.13K	2.09M	262.13K	+100.00%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.34%	285.89K	2.28M	37.67K	+15.18%
Dec 31, 2023	NEW LEAF VENTURE PARTNERS, L.L.C.	0.4%	339.57K	2.71M	0	0
Dec 31, 2023	BAILLIE GIFFORD & CO	0.41%	345.92K	2.76M	-22.05K	-5.99%
Dec 31, 2023	TWO SIGMA ADVISERS, LP	0.47%	393.1K	3.14M	4.1K	+1.05%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.52%	432.69K	3.45M	1.15K	+0.27%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.52%	440.32K	3.51M	15.7K	+3.70%
Dec 31, 2023	ALLIANCEBERNSTEIN L.P.	0.59%	492.29K	3.93M	162.66K	+49.35%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.6%	499.53K	3.99M	17.31K	+3.59%
Dec 31, 2023	RENAISSANCE TECHNOLOGIES LLC	0.68%	571.98K	4.56M	69.78K	+13.89%
Dec 31, 2023	DAFNA CAPITAL MANAGEMENT LLC	0.73%	609.91K	4.87M	-19.03K	-3.03%
Dec 31, 2023	NORTHERN TRUST CORP	0.73%	614.56K	4.9M	-21.51K	-3.38%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	0.91%	764.39K	6.1M	83.17K	+12.21%
Dec 31, 2023	JACOBS LEVY EQUITY MANAGEMENT, INC	0.95%	794.28K	6.34M	16.21K	+2.08%
Dec 31, 2023	FRANKLIN RESOURCES INC	1.14%	959.52K	7.66M	362	+0.04%
Dec 31, 2023	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.27%	1.07M	8.52M	12.62K	+1.20%
Dec 31, 2023	PRICE T ROWE ASSOCIATES INC /MD/	1.43%	1.2M	9.59M	54.58K	+4.76%
Dec 31, 2023	EUCLIDEAN CAPITAL LLC	1.56%	1.31M	10.44M	0	0
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.65%	1.38M	11.03M	78.71K	+6.04%
Dec 31, 2023	JPMORGAN CHASE & CO	2.22%	1.86M	14.87M	-424.37K	-18.54%
Dec 31, 2023	DEUTSCHE BANK AG\	2.46%	2.06M	16.46M	2.03M	+6,104.23%
Dec 31, 2023	STATE STREET CORP	3.71%	3.12M	24.88M	280.82K	+9.90%
Dec 31, 2023	BRAIDWELL LP	3.96%	3.32M	26.53M	-749.81K	-18.40%
Dec 31, 2023	ECOR1 CAPITAL, LLC	4.83%	4.06M	32.37M	0	0
Dec 31, 2023	VANGUARD GROUP INC	5.23%	4.39M	35M	-1.13M	-20.55%
Dec 31, 2023	MORGAN STANLEY	5.54%	4.65M	37.11M	1.31M	+39.34%
Sep 30, 2023	NORDEA INVESTMENT MANAGEMENT AB	0.24%	202.71K	-	69	+0.03%
Sep 30, 2023	JUPITER ASSET MANAGEMENT LTD	0.28%	232.22K	-	0	0
Sep 30, 2023	GOLDMAN SACHS GROUP INC	0.3%	248.22K	-	-58.27K	-19.01%
Sep 30, 2023	PANAGORA ASSET MANAGEMENT INC	0.35%	293.53K	-	51.44K	+21.25%
Sep 30, 2023	ALLIANCEBERNSTEIN L.P.	0.39%	329.62K	-	134.93K	+69.31%
Sep 30, 2023	NEW LEAF VENTURE PARTNERS, L.L.C.	0.41%	339.57K	-	0	0
Sep 30, 2023	BAILLIE GIFFORD & CO	0.44%	367.97K	-	-17.09K	-4.44%
Sep 30, 2023	TWO SIGMA ADVISERS, LP	0.47%	389K	-	-55.9K	-12.56%
Sep 30, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.52%	431.55K	-	1.51K	+0.35%
Sep 30, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.58%	482.22K	-	12.57K	+2.68%
Sep 30, 2023	DAFNA CAPITAL MANAGEMENT LLC	0.75%	628.94K	-	-10K	-1.57%
Sep 30, 2023	NORTHERN TRUST CORP	0.76%	636.07K	-	20.2K	+3.28%
Sep 30, 2023	DIMENSIONAL FUND ADVISORS LP	0.82%	681.23K	-	128.4K	+23.23%
Sep 30, 2023	POINT72 ASSET MANAGEMENT, L.P.	0.88%	738.78K	-	-992.37K	-57.32%
Sep 30, 2023	JACOBS LEVY EQUITY MANAGEMENT, INC	0.93%	778.08K	-	195.41K	+33.54%
Sep 30, 2023	FRANKLIN RESOURCES INC	1.15%	959.16K	-	-652.26K	-40.48%
Sep 30, 2023	BAKER BROS. ADVISORS LP	1.16%	964.85K	-	0	0
Sep 30, 2023	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.26%	1.06M	-	0	0
Sep 30, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.56%	1.3M	-	13.36K	+1.04%
Sep 30, 2023	EUCLIDEAN CAPITAL LLC	1.57%	1.31M	-	326.96K	+33.33%
Sep 30, 2023	MORGAN STANLEY	4%	3.34M	-	1.61M	+92.68%
Sep 30, 2023	ECOR1 CAPITAL, LLC	4.86%	4.06M	-	0	0
Sep 30, 2023	BLACKROCK INC.	9.26%	7.73M	-	-94.58K	-1.21%
Sep 30, 2023	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0.08%	69.26K	-	-6.63K	-8.74%
Sep 30, 2023	STRS OHIO	0.09%	73.2K	-	0	0
Sep 30, 2023	AMERICAN CENTURY COMPANIES INC	0.09%	75.67K	-	-28.55K	-27.40%
Sep 30, 2023	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.09%	78.21K	-	82	+0.11%
Sep 30, 2023	CITIGROUP INC	0.1%	79.52K	-	-388	-0.49%
Sep 30, 2023	UBS GROUP AG	0.1%	79.68K	-	-11.36K	-12.48%
Sep 30, 2023	AMERIPRISE FINANCIAL INC	0.1%	80.07K	-	-91.05K	-53.21%
Sep 30, 2023	BNP PARIBAS ARBITRAGE, SNC	0.1%	80.67K	-	28.77K	+55.43%
Sep 30, 2023	CREDIT SUISSE AG/	0.1%	83.68K	-	5.57K	+7.14%
Sep 30, 2023	RHUMBLINE ADVISERS	0.11%	87.68K	-	-2.93K	-3.24%
Sep 30, 2023	DEKABANK DEUTSCHE GIROZENTRALE	0.12%	100K	-	0	0
Sep 30, 2023	FMR LLC	14.58%	12.17M	-	4.48M	+58.27%
Sep 30, 2023	TWO SIGMA INVESTMENTS, LP	0.12%	102.43K	-	-185.29K	-64.40%
Sep 30, 2023	D. E. SHAW & CO., INC.	0.14%	119.02K	-	100.82K	+554.12%
Sep 30, 2023	TD ASSET MANAGEMENT INC	0.14%	119.14K	-	107.87K	+957.22%
Sep 30, 2023	RUSSELL INVESTMENTS GROUP, LTD.	0.14%	120.12K	-	20.11K	+20.10%
Sep 30, 2023	VICTORY CAPITAL MANAGEMENT INC	0.16%	134.72K	-	-14.77K	-9.88%
Sep 30, 2023	SWISS NATIONAL BANK	0.16%	135.6K	-	0	0
Sep 30, 2023	BARCLAYS PLC	0.17%	138.83K	-	26.86K	+23.99%
Sep 30, 2023	STATE OF WISCONSIN INVESTMENT BOARD	0.18%	147.74K	-	3.61K	+2.51%
Sep 30, 2023	ACADIAN ASSET MANAGEMENT LLC	0.18%	153.27K	-	62.16K	+68.22%
Sep 30, 2023	FEDERATED HERMES, INC.	0.19%	155.66K	-	-332.08K	-68.09%
Sep 30, 2023	LOS ANGELES CAPITAL MANAGEMENT LLC	0.2%	170.2K	-	170.2K	+100.00%
Sep 30, 2023	ALPHABET INC.	0.21%	175.87K	-	0	0
Sep 30, 2023	RAFFERTY ASSET MANAGEMENT, LLC	0.22%	186.62K	-	20.33K	+12.22%
Sep 30, 2023	HRT FINANCIAL LP	0.23%	193.29K	-	193.29K	+100.00%
Sep 30, 2023	BANK OF NEW YORK MELLON CORP	0.28%	232K	-	-2.78K	-1.18%

Insiders

Insiders	Designation	Shares Held
MCGUIRE TERRANCE		10.85M
POLARIS VENTURE MANAGEMENT CO. VI, L.L.C.	10 percent owner	10.85M
ROSENTHAL ARNON	Chief Executive Officer	2.42M
KING ROBERT	Chief Development Officer	529.3K
KENKARE-MITRA SARA	President and Head of R&D	501.65K
BERKLEY NEIL LINDSAY	Chief Bus Ofcr & Interim CFO	374.31K
ROMANO GARY	Chief Medical Officer	332.98K
GRASSO MARC	Chief Financial Officer	296.07K
PAUL ROBERT	Chief Medical Officer	234.32K
WONG-SARAD GRACE	Principal Accounting Officer	122.98K
SULIMAN SHEHNAAZ	President and COO	102.6K
YAFFE KRISTINE	director	95.41K
YU CALVIN	Vice President, Finance	76.69K
HAMMOND PAULA	director	74.91K
SCHELLER RICHARD H	director	35K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Dec 05, 2025	WONG-SARAD GRACE	SALE	1.21	4.75K	5.75K	122.98K
Dec 03, 2025	ROSENTHAL ARNON	SALE	1.12	104.35K	116.83K	2.42M
Dec 03, 2025	WONG-SARAD GRACE	SALE	1.12	8.06K	9.02K	127.74K
Dec 03, 2025	BERKLEY NEIL LINDSAY	SALE	1.12	37.26K	41.72K	374.31K
Dec 03, 2025	KENKARE-MITRA SARA	SALE	1.12	41.69K	46.67K	501.65K
Sep 02, 2025	KENKARE-MITRA SARA	SALE	2.50	23.64K	59.02K	543.34K
Sep 02, 2025	WONG-SARAD GRACE	SALE	2.50	5.91K	14.76K	103.45K
Sep 02, 2025	BERKLEY NEIL LINDSAY	SALE	2.50	15.84K	39.55K	346.57K
Sep 02, 2025	ROSENTHAL ARNON	SALE	2.50	51.56K	128.74K	2.35M
Aug 26, 2025	HAMMOND PAULA	SALE	2.36	14K	33K	74.91K
Jun 20, 2025	YAFFE KRISTINE	SALE	1.44	1K	1.44K	95.41K
Jun 02, 2025	ROSENTHAL ARNON	SALE	1.34	52.09K	69.71K	2.41M
Jun 02, 2025	KENKARE-MITRA SARA	SALE	1.34	23.89K	31.97K	512.25K
Jun 02, 2025	GRASSO MARC	SALE	1.34	16.49K	22.07K	296.07K
Mar 03, 2025	ROMANO GARY	SALE	1.47	16.31K	23.93K	332.98K
Mar 03, 2025	GRASSO MARC	SALE	1.47	18.09K	26.55K	312.56K
Mar 03, 2025	ROSENTHAL ARNON	SALE	1.47	40.33K	59.18K	2.47M
Mar 03, 2025	KENKARE-MITRA SARA	SALE	1.47	29.07K	42.66K	536.14K
Dec 02, 2024	ROMANO GARY	SALE	2.52	14.89K	37.52K	349.28K
Dec 02, 2024	KENKARE-MITRA SARA	SALE	2.52	26.5K	66.76K	565.22K
Dec 02, 2024	ROSENTHAL ARNON	SALE	2.52	52.17K	131.44K	2.51M
Dec 02, 2024	GRASSO MARC	SALE	2.52	16.49K	41.54K	330.65K
Sep 03, 2024	GRASSO MARC	SALE	4.88	7.3K	35.62K	130.74K
Sep 03, 2024	ROSENTHAL ARNON	SALE	4.88	26.5K	129.39K	1.95M
Sep 03, 2024	KENKARE-MITRA SARA	SALE	4.88	13.93K	67.98K	291.72K
Sep 03, 2024	ROMANO GARY	SALE	4.88	8.48K	41.39K	179.8K
Aug 22, 2024	SCHELLER RICHARD H	SALE	5.16	44.25K	228.39K	35K
Aug 12, 2024	YAFFE KRISTINE	SALE	5.06	5K	25.31K	67.71K
Aug 12, 2024	HAMMOND PAULA	SALE	5.06	10.5K	53.18K	60.21K
Jun 03, 2024	ROSENTHAL ARNON	SALE	4.80	25.14K	120.62K	1.98M
Jun 03, 2024	ROMANO GARY	SALE	4.80	8.04K	38.58K	188.27K
Jun 03, 2024	GRASSO MARC	SALE	4.80	6.92K	33.21K	138.04K
Jun 03, 2024	KENKARE-MITRA SARA	SALE	4.80	13.21K	63.37K	305.64K
Mar 04, 2024	ROMANO GARY	SALE	6.92	6K	41.55K	196.31K
Mar 04, 2024	GRASSO MARC	SALE	6.92	5.72K	39.56K	144.96K
Mar 04, 2024	KENKARE-MITRA SARA	SALE	6.92	10.17K	70.39K	318.85K
Mar 04, 2024	ROSENTHAL ARNON	SALE	6.92	18.84K	130.39K	2M
Dec 04, 2023	KENKARE-MITRA SARA	SALE	5.56	12.52K	69.61K	329.02K
Dec 04, 2023	ROSENTHAL ARNON	SALE	5.56	23.83K	132.5K	2.02M
Dec 04, 2023	GRASSO MARC	SALE	5.56	4.57K	25.43K	150.67K
Dec 04, 2023	ROMANO GARY	SALE	5.56	5.04K	27.99K	202.31K
Sep 11, 2023	MCGUIRE TERRANCE	SALE	6.00	500K	3M	10.85M
Sep 11, 2023	POLARIS VENTURE MANAGEMENT CO. VI, L.L.C.	SALE	6.00	500K	3M	10.85M
Sep 05, 2023	ROSENTHAL ARNON	SALE	5.19	5.65K	29.33K	1.65M
Sep 05, 2023	GRASSO MARC	SALE	5.19	1.11K	5.79K	32.25K
Sep 05, 2023	ROMANO GARY	SALE	5.19	2.77K	14.39K	99.35K
Sep 05, 2023	KENKARE-MITRA SARA	SALE	5.19	6.21K	32.28K	177.94K
Jun 02, 2023	KENKARE-MITRA SARA	SALE	6.90	4.09K	28.25K	184.15K
Jun 02, 2023	GRASSO MARC	SALE	6.90	1.05K	7.25K	33.36K
Jun 02, 2023	ROMANO GARY	SALE	6.90	2.62K	18.07K	102.12K
Jun 02, 2023	ROSENTHAL ARNON	SALE	6.90	5.26K	36.28K	1.65M
Mar 17, 2023	ROSENTHAL ARNON	SALE	6.22	15.19K	94.43K	1.66M
Mar 02, 2023	ROSENTHAL ARNON	SALE	8.32	5.85K	48.65K	1.63M
Mar 02, 2023	GRASSO MARC	SALE	8.32	1.29K	10.74K	34.41K
Mar 02, 2023	KENKARE-MITRA SARA	SALE	8.32	10.12K	84.22K	188.24K
Mar 02, 2023	ROMANO GARY	SALE	8.32	3.24K	26.93K	104.74K
Dec 02, 2022	ROMANO GARY	SALE	8.71	2.15K	18.68K	107.98K
Sep 02, 2022	KING ROBERT	SALE	10.62	176	1.87K	529.3K
Sep 02, 2022	ROMANO GARY	SALE	10.62	2.18K	23.12K	90.07K
Jun 02, 2022	KING ROBERT	SALE	8.71	177	1.54K	529.47K
Mar 01, 2022	KING ROBERT	SALE	15.57	287	4.47K	528.4K
Dec 13, 2021	SULIMAN SHEHNAAZ	SALE	21.73	10.9K	236.8K	102.6K
Dec 10, 2021	SULIMAN SHEHNAAZ	SALE	22.33	8.87K	198.19K	102.6K
Dec 09, 2021	SULIMAN SHEHNAAZ	SALE	23.40	2.64K	61.86K	102.6K
Dec 08, 2021	SULIMAN SHEHNAAZ	SALE	23.01	38.49K	885.69K	102.6K
Dec 01, 2021	KING ROBERT	SALE	20.09	250	5.02K	528.69K
Nov 11, 2021	ROSENTHAL ARNON	SALE	25.00	55K	1.38M	1.97M
Nov 10, 2021	ROSENTHAL ARNON	SALE	25.00	55K	1.38M	2.03M
Nov 09, 2021	ROSENTHAL ARNON	SALE	25.00	15K	375K	652.5K
Nov 08, 2021	ROSENTHAL ARNON	SALE	25.00	15K	375K	667.5K
Nov 05, 2021	ROSENTHAL ARNON	SALE	25.00	15K	375K	682.5K
Nov 04, 2021	ROSENTHAL ARNON	SALE	25.00	15K	375K	697.5K
Sep 23, 2021	ROSENTHAL ARNON	SALE	25.10	9.63K	241.57K	2.3M
Sep 22, 2021	ROSENTHAL ARNON	SALE	26.10	5.28K	137.89K	2.31M
Sep 21, 2021	ROSENTHAL ARNON	SALE	26.56	8.46K	224.74K	2.41M
Sep 20, 2021	ROSENTHAL ARNON	SALE	26.33	8.05K	211.85K	2.51M
Aug 09, 2021	PAUL ROBERT	SALE	27.79	300	8.34K	234.32K
Aug 05, 2021	SCHELLER RICHARD H	SALE	28.30	3.39K	96K	0
Jul 07, 2021	PAUL ROBERT	SALE	39.32	17.15K	674.22K	234.32K
Jul 06, 2021	PAUL ROBERT	SALE	40.01	1.1K	44.02K	234.32K
Jul 06, 2021	YU CALVIN	SALE	34.65	3.33K	115.52K	76.69K
Jul 02, 2021	YU CALVIN	SALE	40.02	20K	800.32K	76.69K
Jul 02, 2021	SCHELLER RICHARD H	SALE	31.14	9.98K	310.81K	0
Jul 02, 2021	PAUL ROBERT	SALE	31.14	30K	934.2K	234.32K
Jul 02, 2021	KING ROBERT	SALE	31.14	60K	1.87M	522.32K
Jul 01, 2021	PAUL ROBERT	SALE	22.23	26.73K	594.12K	246.99K
Jun 16, 2021	PAUL ROBERT	SALE	22.18	4.6K	102.05K	273.72K
Jun 15, 2021	PAUL ROBERT	SALE	22.07	30K	661.95K	273.72K
Jun 08, 2021	PAUL ROBERT	SALE	20.83	800	16.66K	273.72K
Jun 02, 2021	YU CALVIN	SALE	17.77	1.84K	32.77K	126.69K
May 21, 2021	PAUL ROBERT	SALE	18.14	14.98K	271.68K	273.72K
May 18, 2021	PAUL ROBERT	SALE	18.04	4.2K	75.79K	273.72K
Apr 07, 2021	PAUL ROBERT	SALE	19.83	45	892.35	213.72K
Mar 23, 2021	PAUL ROBERT	SALE	22.21	13.8K	306.5K	213.72K
Mar 22, 2021	PAUL ROBERT	SALE	23.55	5.51K	129.77K	213.72K
Mar 09, 2021	PAUL ROBERT	SALE	18.12	19.18K	347.4K	213.72K
Feb 09, 2021	PAUL ROBERT	SALE	20.81	19.18K	399.05K	213.72K
Jan 26, 2021	PAUL ROBERT	SALE	18.00	27.31K	491.54K	213.72K
Jan 25, 2021	PAUL ROBERT	SALE	18.01	30K	540.23K	213.72K
Jan 20, 2021	PAUL ROBERT	SALE	18.00	8.57K	154.21K	213.72K
Jan 19, 2021	PAUL ROBERT	SALE	18.12	30K	543.55K	213.72K
Jul 15, 2020	PAUL ROBERT	SALE	23.58	378	8.91K	213.72K
Jun 23, 2020	POLARIS VENTURE MANAGEMENT CO. VI, L.L.C.	SALE	31.54	4.38K	138.06K	12.85M
Jun 23, 2020	MCGUIRE TERRANCE	SALE	31.54	4.38K	138.06K	12.85M
Jun 15, 2020	PAUL ROBERT	SALE	29.90	3.91K	116.88K	223.72K
Jun 03, 2020	YU CALVIN	SALE	31.04	1.04K	32.37K	110.99K
May 15, 2020	PAUL ROBERT	SALE	26.15	1.9K	49.69K	241.82K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES307.06K10

NET SHARES-307.06K10

SHARES HELD6.97M10

% NET SHARES-104.41%0%

ALEC Stock Ownership Breakdown

Alector

Stock Outstanding Shares

Market Insider

Institutional Ownership

Insiders

Buying/Selling by Insiders

Insider Transaction Summary (6 Months)

Frequently Asked Questions

Stock Outstanding Shares

Market Insider

Institutional Ownership

Insiders

Buying/Selling by Insiders

Insider Transaction Summary (6 Months)

Frequently Asked Questions