How many institutions own ACET stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own ACET shares is 57, representing 36.36% of the company's common stock.

Who are the major shareholders selling Adicet Bio, Inc. stock?

FMR LLC, in the last quarter, reduced its stake in ACET by -99.68% restricting it's holding to 776 shares of worth nearly $629.00. RIGGS ASSET MANAGMENT CO. INC. also lessened -100% of the ACET shares from its portfolio, reducing its holding to 0 shares of worth -. DIMENSIONAL FUND ADVISORS LP also shunned ACET shares holding by -7.52% last quarter which brought its holding to 52.96 thousand shares worth $42.91K.

Investors who are buying ACET stock?

As per its latest 13F filing, QUBE RESEARCH & TECHNOLOGIES LTD increased its stake in ACET by 1.5% in the last quarter. The institutional holder raised its holding to 20.26 thousand shares having worth more than $16.41K. UBS GROUP AG also added 15.83% more shares of ACET to its portfolio, raising its holding to 21.44 thousand shares of worth $17.37K. VIRTU FINANCIAL LLC also increased its ACET shares holding by 100% which brought its holding to 79.92 thousand shares worth $65.00K.

ACET's major insiders: who are they?

The insider with the most stakes in ACET is SILVERSTEIN JONATHAN , at the company. Additionally, ACET stock is highly held by 10 percent owner ORBIMED ADVISORS LLC and director Sinclair Andrew among others.

Did an insider recently sell ACET stock?

Company executives, directors, and other insiders own 1.46% percent of Adicet Bio, Inc.'s stock. Within the last six months, there have been 0 transaction(s) in which ACET insiders have sold stock, totaling 0 shares. Insiders that have sold shares include KAUFFMAN MICHAEL, SCHOR CHEN, and HEALEY DON.

Which insider recently purchased ACET stock?

There have been 1 transaction(s) during the past 6-months in which Adicet Bio, Inc. insiders have bought stock, totalling 3500000 shares

How much of ACET does insiders own?

Around 4.49M Adicet Bio, Inc. shares are held by insiders, which represents about 1.46% of ACET stock.

Who is the insider with the largest stake?

ACET , SILVERSTEIN JONATHAN holds the largest portfolio of the company's shares. ACET shares owned by SILVERSTEIN total nearly 4.83 million.

Which institution holds the most shares in ACET?

REGENERON PHARMACEUTICALS, INC. is the largest institutional owner in ACET which holds 968.18 thousand shares worth $784.42K or 1.06% of the total ACET shares outstanding followed by VANGUARD GROUP INC with ownership of 3.27 million shares representing 3.59% of the ACET ownership. FMR LLC is the third largest stakeholder with 776 shares or 0% of the ownership worth more than $629.00.

Is Adicet Bio, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the ACET is concerned, it is a stock which is optionable.

Is there a short position on ACET's shares?

Number of ACET shares short is 931.91K. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding ACET shares are there?

As of today, 153.26M shares of ACET are outstanding.

Is there many float in ACET stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, ACET has 8.41M shares in float.

ACET short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for ACET is 6.16.

Adicet Bio (ACET) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares0.61

Short Percent Of Float0.72

Shares Outstanding153.26M

Shares Float8.41M

Shares Short931.91K

Short Ratio6.16

0.72%

Short % of Float

0.61%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

1.46% Percentage of Shares held by All Insiders

36.36% Percentage of Shares held by All Institutions

36.9% Percentage of Float held by Institutions

Number of Institutions Holding Shares

Institutional Ownership

About 36.36% of ACET shares are held by financial institutions. REGENERON PHARMACEUTICALS, INC. is the top corporate investor, holding 968.18K shares valued at $784.42K. A 1.06% stake in Adicet Bio, Inc. is owned by the company. VANGUARD GROUP INC owns 3.27M shares valued at $2.65M, which translates its holding of 3.59% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	REGENERON PHARMACEUTICALS, INC.	1.06%	968.18K	784.42K	0	0
Sep 30, 2025	VANGUARD GROUP INC	3.59%	3.27M	2.65M	0	0
Sep 30, 2025	FMR LLC	0%	776	629	-244K	-99.68%
Sep 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.02%	20.26K	16.41K	300	+1.50%
Sep 30, 2025	RIGGS ASSET MANAGMENT CO. INC.	0%	0	-	-1.12K	-100.00%
Sep 30, 2025	UBS GROUP AG	0.02%	21.44K	17.37K	2.93K	+15.83%
Sep 30, 2025	ABACUS PLANNING GROUP, INC.	0.04%	36.76K	29.79K	0	0
Sep 30, 2025	VIRTU FINANCIAL LLC	0.09%	79.92K	65K	79.92K	+100.00%
Sep 30, 2025	XTX TOPCO LTD	0.06%	58.14K	47.1K	34.56K	+146.56%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.06%	52.96K	42.91K	-4.31K	-7.52%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.04%	40.37K	32.71K	40.37K	+100.00%
Sep 30, 2025	HRT FINANCIAL LP	0.02%	18.63K	15K	18.63K	+100.00%
Sep 30, 2025	RAYMOND JAMES FINANCIAL INC	0.01%	13.27K	10.75K	9.51K	+253.54%
Sep 30, 2025	TOWER RESEARCH CAPITAL LLC (TRC)	0.01%	4.99K	4.05K	-24.07K	-82.82%
Sep 30, 2025	HOLLENCREST CAPITAL MANAGEMENT	0%	2K	1.62K	0	0
Sep 30, 2025	SBI SECURITIES CO., LTD.	0%	827	670	5	+0.61%
Sep 30, 2025	LANDSCAPE CAPITAL MANAGEMENT, L.L.C.	0%	0	-	-17.85K	-100.00%
Sep 30, 2025	LUMINUS MANAGEMENT LLC	0%	0	-	-289.94K	-100.00%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0%	0	-	-30K	-100.00%
Sep 30, 2025	CITIGROUP INC	0%	166	134	-542	-76.55%
Sep 30, 2025	VONTOBEL HOLDING LTD.	0.09%	80K	65.18K	0	0
Sep 30, 2025	TWO SIGMA SECURITIES, LLC	0.03%	25.27K	20.48K	25.27K	+100.00%
Sep 30, 2025	JPMORGAN CHASE & CO	0%	771	625	0	0
Sep 30, 2025	MARSHALL WACE, LLP	0.06%	51.73K	41.9K	51.73K	+100.00%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	2.01%	1.83M	1.48M	675.13K	+58.51%
Sep 30, 2025	CARLYLE GROUP INC.	3.24%	2.95M	2.39M	0	0
Sep 30, 2025	ACADIAN ASSET MANAGEMENT LLC	2.49%	2.27M	1.84M	190.89K	+9.20%
Sep 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.72%	655.67K	531.22K	0	0
Sep 30, 2025	CITADEL ADVISORS LLC	0.64%	583.95K	473.12K	123.54K	+26.83%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.62%	565.95K	458.54K	-26.37K	-4.45%
Sep 30, 2025	WEALTHEDGE INVESTMENT ADVISORS, LLC	0.33%	300.05K	243.1K	-13.05K	-4.17%
Sep 30, 2025	BARCLAYS PLC	0.33%	300K	243.06K	150K	+100.00%
Sep 30, 2025	STATE STREET CORP	0.27%	244.19K	197.84K	-2.74K	-1.11%
Sep 30, 2025	JANE STREET GROUP, LLC	0.2%	186.2K	150.86K	186.2K	+100.00%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.02%	20.61K	16.69K	-28	-0.14%
Sep 30, 2025	RANGELEY CAPITAL, LLC	0.08%	75K	60.77K	75K	+100.00%
Sep 30, 2025	MARINER, LLC	0.02%	14.85K	12.03K	14.85K	+100.00%
Sep 30, 2025	ORBIMED ADVISORS LLC	12.57%	11.45M	9.27M	0	0
Sep 30, 2025	TANG CAPITAL MANAGEMENT LLC	9.03%	8.22M	6.66M	0	0
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	8.28%	7.54M	6.11M	0	0
Sep 30, 2025	GOLDMAN SACHS GROUP INC	4.12%	3.75M	3.04M	-481	-0.01%
Sep 30, 2025	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.99%	901.6K	730.48K	0	0
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.94%	854.57K	692.37K	341.76K	+66.65%
Sep 30, 2025	TWO SIGMA ADVISERS, LP	0.86%	780.98K	632.75K	214.94K	+37.97%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.78%	706.33K	572.44K	0	0
Sep 30, 2025	RBF CAPITAL, LLC	0.68%	617.32K	500.15K	0	0
Sep 30, 2025	BLACKROCK, INC.	0.64%	585.38K	474.27K	-14.11K	-2.35%
Sep 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.53%	479.11K	388.17K	-1.4M	-74.52%
Sep 30, 2025	ADVISOR GROUP HOLDINGS, INC.	0%	10	7	10	+100.00%
Sep 30, 2025	DAFNA CAPITAL MANAGEMENT LLC	0%	0	-	-540K	-100.00%
Sep 30, 2025	JOHNSON & JOHNSON	0.4%	364.47K	295.3K	0	0
Sep 30, 2025	MORGAN STANLEY	0.08%	73.68K	59.7K	1.46K	+2.02%
Sep 30, 2025	SQUAREPOINT OPS LLC	0.05%	46.43K	37.62K	46.43K	+100.00%
Sep 30, 2025	TOTH FINANCIAL ADVISORY CORP	0%	1.6K	1.3K	0	0
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0%	896	726	0	0
Sep 30, 2025	NORTHERN TRUST CORP	0.15%	140.37K	113.73K	0	0
Sep 30, 2025	ROYAL BANK OF CANADA	0.09%	80.11K	65K	80.11K	+100.00%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.02%	20.64K	12.59K	94	+0.46%
Jun 30, 2025	SIMPLEX TRADING, LLC	0%	0	-	-1.86K	-100.00%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.65%	592.33K	361.32K	-631.54K	-51.60%
Jun 30, 2025	SBI SECURITIES CO., LTD.	0%	822	501	58	+7.59%
Jun 30, 2025	WEALTHEDGE INVESTMENT ADVISORS, LLC	0.34%	313.11K	191K	85.31K	+37.45%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.06%	57.27K	34.93K	-90.55K	-61.26%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.03%	30K	18.3K	0	0
Jun 30, 2025	TOWER RESEARCH CAPITAL LLC (TRC)	0.03%	29.06K	17.73K	10.77K	+58.90%
Jun 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.02%	19.96K	12.17K	-33.88K	-62.93%
Jun 30, 2025	ORBIMED ADVISORS LLC	12.57%	11.45M	6.98M	0	0
Jun 30, 2025	LANDSCAPE CAPITAL MANAGEMENT, L.L.C.	0.02%	17.85K	10.89K	17.85K	+100.00%
Jun 30, 2025	HOLLENCREST CAPITAL MANAGEMENT	0%	2K	1.22K	1.1K	+122.22%
Jun 30, 2025	TOTH FINANCIAL ADVISORY CORP	0%	1.6K	976	1.6K	+100.00%
Jun 30, 2025	SQUAREPOINT OPS LLC	0%	0	-	-11.57K	-100.00%
Jun 30, 2025	POINT72 ASIA (SINGAPORE) PTE. LTD.	0%	0	-	-13.47K	-100.00%
Jun 30, 2025	POINT72 (DIFC) LTD	0%	0	-	-95	-100.00%
Jun 30, 2025	ABACUS PLANNING GROUP, INC.	0.04%	36.76K	22.43K	36.76K	+100.00%
Jun 30, 2025	XTX TOPCO LTD	0.03%	23.58K	14.38K	23.58K	+100.00%
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	2.06%	1.88M	1.15M	1.88M	+100.00%
Jun 30, 2025	REGENERON PHARMACEUTICALS, INC.	1.06%	968.18K	590.59K	0	0
Jun 30, 2025	STONEPINE CAPITAL MANAGEMENT, LLC	0%	0	-	-508.27K	-100.00%
Jun 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0%	896	547	2	+0.22%
Jun 30, 2025	COLDSTREAM CAPITAL MANAGEMENT INC	0%	0	-	-8.88K	-100.00%
Jun 30, 2025	CITIGROUP INC	0%	708	432	-1.58K	-69.08%
Jun 30, 2025	RIGGS ASSET MANAGMENT CO. INC.	0%	1.12K	685	1.12K	+100.00%
Jun 30, 2025	RAYMOND JAMES FINANCIAL INC	0%	3.75K	2.29K	3.75K	+100.00%
Jun 30, 2025	TWO SIGMA ADVISERS, LP	0.62%	566.04K	345.28K	-56.8K	-9.12%
Jun 30, 2025	FMR LLC	0.27%	244.78K	149.32K	-4.21K	-1.69%
Jun 30, 2025	STATE STREET CORP	0.27%	246.92K	150.62K	0	0
Jun 30, 2025	JOHNSON & JOHNSON	0.4%	364.47K	228.01K	0	0
Jun 30, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.59%	540K	329.4K	-60K	-10.00%
Jun 30, 2025	RBF CAPITAL, LLC	0.68%	617.32K	376.57K	0	0
Jun 30, 2025	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.99%	901.6K	549.98K	0	0
Jun 30, 2025	ACADIAN ASSET MANAGEMENT LLC	2.28%	2.07M	1.26M	35.28K	+1.73%
Jun 30, 2025	CARLYLE GROUP INC.	3.24%	2.95M	1.8M	0	0
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	8.28%	7.54M	4.6M	0	0
Jun 30, 2025	TANG CAPITAL MANAGEMENT LLC	9.03%	8.22M	5.02M	0	0
Jun 30, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0%	0	-	-12.4K	-100.00%
Jun 30, 2025	JANE STREET GROUP, LLC	0%	0	-	-16.3K	-100.00%
Jun 30, 2025	GROUND SWELL CAPITAL, LLC	0%	0	-	-15.95K	-100.00%
Jun 30, 2025	VIRTU FINANCIAL LLC	0%	0	-	-23.73K	-100.00%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	4.12%	3.75M	2.29B	-64.46K	-1.69%
Jun 30, 2025	VANGUARD GROUP INC	3.59%	3.27M	2M	66.64K	+2.08%
Jun 30, 2025	MORGAN STANLEY	0.08%	72.23K	44.06M	70.54K	+4,191.50%
Jun 30, 2025	CITADEL ADVISORS LLC	0.03%	27.2K	16.59M	-9.7K	-26.29%
Jun 30, 2025	D. E. SHAW & CO., INC.	0.02%	22.2K	13.54M	-483.27K	-95.61%
Jun 30, 2025	UBS GROUP AG	0.02%	18.51K	11.29K	-45.53K	-71.10%
Jun 30, 2025	VONTOBEL HOLDING LTD.	0.09%	80K	48.8K	20K	+33.33%
Jun 30, 2025	BLACKSTONE INC.	0%	0	-	-1.24M	-100.00%
Jun 30, 2025	CAXTON CORP	0%	0	-	-17.49K	-100.00%
Jun 30, 2025	PRELUDE CAPITAL MANAGEMENT, LLC	0%	0	-	-34.25K	-100.00%
Jun 30, 2025	THOMPSON INVESTMENT MANAGEMENT, INC.	0%	0	-	-80	-100.00%
Jun 30, 2025	GROUP ONE TRADING, L.P.	0%	0	-	-6.79K	-100.00%
Jun 30, 2025	STONEX GROUP INC.	0%	0	-	-12.45K	-100.00%
Jun 30, 2025	JPMORGAN CHASE & CO	0%	771	470	-399	-34.10%
Jun 30, 2025	BLACKROCK, INC.	0.66%	599.49K	365.69K	-149.58K	-19.97%
Jun 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.72%	655.67K	399.96K	0	0
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.78%	706.33K	430.98K	-64.37K	-8.35%
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	1.27%	1.15M	703.83K	343.12K	+42.32%
Jun 30, 2025		0%	822	501	58	+7.59%
Jun 30, 2025	NORTHERN TRUST CORP	0.15%	140.37K	85.63K	0	0
Jun 30, 2025	BARCLAYS PLC	0.16%	150K	92K	150K	+100.00%
Jun 30, 2025	LUMINUS MANAGEMENT LLC	0.32%	289.94K	176.86K	289.94K	+100.00%
Jun 30, 2025	TWO SIGMA INVESTMENTS, LP	0.56%	512.81K	312.81K	17.83K	+3.60%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.89%	810.7K	612.08K	-105.8K	-11.54%
Mar 31, 2025	CAXTON CORP	0.02%	17.49K	13.2K	0	0
Mar 31, 2025	TOWER RESEARCH CAPITAL LLC (TRC)	0.02%	18.29K	13.81K	18.29K	+100.00%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.02%	20.54K	15.51K	-16.82K	-45.02%
Mar 31, 2025	VIRTU FINANCIAL LLC	0.03%	23.73K	18K	-6.88K	-22.49%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	4.19%	3.82M	2.88M	63.69K	+1.70%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.03%	30K	22.65K	0	0
Mar 31, 2025	PRELUDE CAPITAL MANAGEMENT, LLC	0.04%	34.25K	25.86K	5.34K	+18.46%
Mar 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.06%	53.83K	40.65K	-82.27K	-60.45%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.54%	494.98K	373.71K	-208.38K	-29.63%
Mar 31, 2025	CITIGROUP INC	0%	2.29K	1.73K	2.05K	+846.28%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.5%	457.72K	345.58K	-19.95K	-4.18%
Mar 31, 2025	TWO SIGMA ADVISERS, LP	0.68%	622.84K	470.24K	-171.2K	-21.56%
Mar 31, 2025	BLACKROCK, INC.	0.82%	749.07K	565.55K	-62.71K	-7.72%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.85%	770.7K	582.06K	3.16K	+0.41%
Mar 31, 2025	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.99%	901.6K	680.71K	-125K	-12.18%
Mar 31, 2025	BLACKSTONE INC.	1.36%	1.24M	933.52K	0	0
Mar 31, 2025	VONTOBEL HOLDING LTD.	0.07%	60K	46.59K	10K	+20.00%
Mar 31, 2025	NORTHERN TRUST CORP	0.15%	140.37K	105.98K	4	0.00%
Mar 31, 2025	VANGUARD GROUP INC	3.52%	3.21M	2.42M	0	0
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	8.28%	7.54M	5.69M	0	0
Mar 31, 2025	GROUP ONE TRADING, L.P.	0.01%	6.79K	5.13K	-4.41K	-39.36%
Mar 31, 2025	COLDSTREAM CAPITAL MANAGEMENT INC	0.01%	8.88K	6.7K	8.88K	+100.00%
Mar 31, 2025	ORBIMED ADVISORS LLC	12.57%	11.45M	8.64M	0	0
Mar 31, 2025	TANG CAPITAL MANAGEMENT LLC	9.03%	8.22M	6.21M	77.62K	+0.95%
Mar 31, 2025	UBS GROUP AG	0.07%	64.04K	48.35K	-139.19K	-68.49%
Mar 31, 2025	JOHNSON & JOHNSON	0.4%	364.47K	275.18K	0	0
Mar 31, 2025	GROUND SWELL CAPITAL, LLC	0.02%	15.95K	12.04K	15.95K	+100.00%
Mar 31, 2025	JANE STREET GROUP, LLC	0.02%	16.3K	12.31K	3.99K	+32.38%
Mar 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.72%	655.67K	495.03K	0	0
Mar 31, 2025	REGENERON PHARMACEUTICALS, INC.	1.06%	968.18K	730.98K	0	0
Mar 31, 2025		0.25%	227.8K	171.99K	154.04K	+208.82%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	1.34%	1.22M	924.02K	-590.45K	-32.54%
Mar 31, 2025	ACADIAN ASSET MANAGEMENT LLC	2.24%	2.04M	1.54M	36.28K	+1.81%
Mar 31, 2025	AQUILO CAPITAL MANAGEMENT, LLC	2.7%	2.46M	1.85M	-75K	-2.96%
Mar 31, 2025	CARLYLE GROUP INC.	3.24%	2.95M	2.28M	0	0
Mar 31, 2025	STONEPINE CAPITAL MANAGEMENT, LLC	0.56%	508.27K	203.5K	-191.73K	-27.39%
Mar 31, 2025	SQUAREPOINT OPS LLC	0.01%	11.57K	8.73K	-172.79K	-93.73%
Mar 31, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0.01%	12.4K	9.36K	-118	-0.94%
Mar 31, 2025	STONEX GROUP INC.	0.01%	12.45K	9.4K	12.45K	+100.00%
Mar 31, 2025	POINT72 ASIA (SINGAPORE) PTE. LTD.	0.01%	13.47K	10.17K	-26.52K	-66.32%
Mar 31, 2025	CITADEL ADVISORS LLC	0.02%	16.5K	12.46K	-12.2K	-42.51%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.16%	147.81K	111.76K	0	0
Mar 31, 2025	STATE STREET CORP	0.27%	246.92K	186.43K	0	0
Mar 31, 2025	FMR LLC	0.27%	248.99K	187.99K	-56.92K	-18.61%
Mar 31, 2025	D. E. SHAW & CO., INC.	0.56%	505.47K	381.63K	-341.6K	-40.33%
Mar 31, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.66%	600K	453K	0	0
Mar 31, 2025	RBF CAPITAL, LLC	0.68%	617.32K	466.08K	16.18K	+2.69%
Mar 31, 2024	CARLYLE GROUP INC.	6.85%	2.95M	6.9M	833.33K	+39.39%
Mar 31, 2024	CORNERCAP INVESTMENT COUNSEL INC	0.09%	38.21K	89.79K	0	0
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.09%	36.74K	86.34K	0	0
Mar 31, 2024	VONTOBEL HOLDING LTD.	0.06%	27K	63.45K	27K	+100.00%
Mar 31, 2024	AMERICAN INTERNATIONAL GROUP, INC.	0.06%	26.32K	61.85K	11.21K	+74.24%
Mar 31, 2024	PANAGORA ASSET MANAGEMENT INC	0.05%	23.19K	54.5K	-28.55K	-55.18%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.04%	18.3K	43.01K	18.3K	+100.00%
Mar 31, 2024	WELLS FARGO & COMPANY/MN	0.04%	18.9K	44.42K	9.52K	+101.52%
Mar 31, 2024	SG AMERICAS SECURITIES, LLC	0.04%	18.48K	43K	2.48K	+15.53%
Mar 31, 2024	DYNAMIC TECHNOLOGY LAB PRIVATE LTD	0.04%	17.53K	41K	17.53K	+100.00%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.04%	16.1K	37.84K	16.1K	+100.00%
Mar 31, 2024	PRINCIPAL FINANCIAL GROUP INC	0.03%	14.66K	34.46K	2.9K	+24.64%
Mar 31, 2024	NEW YORK STATE COMMON RETIREMENT FUND	0.03%	12.85K	30K	1.21K	+10.36%
Mar 31, 2024	INVESCO LTD.	0.03%	12.43K	29.22K	1.99K	+19.03%
Mar 31, 2024	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.03%	11.83K	65.32K	11.83K	+100.00%
Mar 31, 2024	CITIGROUP INC	0.03%	10.84K	25.48K	5.37K	+97.97%
Mar 31, 2024	QUANTBOT TECHNOLOGIES LP	0.01%	5.5K	12.93K	0	0
Mar 31, 2024	LAZARD ASSET MANAGEMENT LLC	0.01%	5.41K	12K	2.71K	+100.19%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.01%	4.74K	11.14M	2K	+72.97%
Mar 31, 2024	GAMMA INVESTING LLC	0.01%	3.83K	9K	0	0
Mar 31, 2024	AMERITAS INVESTMENT PARTNERS, INC.	0.01%	2.15K	5.04M	0	0
Mar 31, 2024	NORTHWEST FINANCIAL ADVISORS	0%	1.69K	3.96K	0	0
Mar 31, 2024	ADVISOR GROUP HOLDINGS, INC.	0%	1.65K	3.88K	0	0
Mar 31, 2024	AMALGAMATED BANK	0%	991	2K	-1.77K	-64.13%
Mar 31, 2024	MORGAN STANLEY	9.45%	4.07M	9.56M	1.27M	+45.32%
Mar 31, 2024	D. E. SHAW & CO., INC.	0.76%	325.95K	765.98K	-20.67K	-5.96%
Mar 31, 2024	ATOM INVESTORS LP	0.6%	259.31K	609.37K	259.31K	+100.00%
Mar 31, 2024	CITADEL ADVISORS LLC	0.55%	238.21K	559.8K	104.99K	+78.80%
Mar 31, 2024	XTX TOPCO LTD	0.53%	226.05K	531.22K	203.05K	+882.78%
Mar 31, 2024	FMR LLC	0.45%	194.2K	456.37K	58.29K	+42.89%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	0.44%	189.33K	444.92K	35.91K	+23.41%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.35%	150.08K	352.68K	80.62K	+116.06%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.34%	146.05K	343.22K	48.51K	+49.74%
Mar 31, 2024	PRUDENTIAL FINANCIAL INC	0.25%	107.2K	251.92K	47.55K	+79.72%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.24%	102K	239.7K	54.26K	+113.64%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.14%	61.89K	145.44K	61.89K	+100.00%
Mar 31, 2024	RHUMBLINE ADVISERS	0.14%	60.5K	142.16K	13.38K	+28.40%
Mar 31, 2024	JPMORGAN CHASE & CO	0.14%	59.24K	139.22K	39.41K	+198.75%
Mar 31, 2024	JANE STREET GROUP, LLC	0.14%	58.59K	137.69K	35.58K	+154.61%
Mar 31, 2024	UBS GROUP AG	0.12%	53.54K	125.81K	30.96K	+137.12%
Mar 31, 2024	BALYASNY ASSET MANAGEMENT L.P.	14.36%	6.18M	14.53M	6.18M	+100.00%
Mar 31, 2024	BLACKROCK INC.	7.84%	3.37M	7.93M	1.19M	+54.55%
Mar 31, 2024	WOODLINE PARTNERS LP	1.71%	735.1K	1.73M	735.1K	+100.00%
Mar 31, 2024	ALYESKA INVESTMENT GROUP, L.P.	1.52%	655.67K	1.54M	655.67K	+100.00%
Mar 31, 2024	DAFNA CAPITAL MANAGEMENT LLC	1.39%	600K	1.41M	600K	+100.00%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	1.21%	521.57K	1.23M	160.85K	+44.59%
Mar 31, 2024	TWO SIGMA ADVISERS, LP	1.18%	506.04K	1.19M	-14K	-2.69%
Mar 31, 2024	NORTHERN TRUST CORP	1.01%	435.62K	1.02M	203.53K	+87.70%
Mar 31, 2024	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.97%	416.29K	978.29K	416.29K	+100.00%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.95%	410.64K	964.99K	216.83K	+111.88%
Mar 31, 2024	JOHNSON & JOHNSON	0.85%	364.47K	856.51K	-324.12K	-47.07%
Mar 31, 2024	ACADIAN ASSET MANAGEMENT LLC	0.83%	355.34K	834K	-204.41K	-36.52%
Mar 31, 2024	SILVERARC CAPITAL MANAGEMENT, LLC	0.77%	331.28K	778.51K	331.28K	+100.00%
Mar 31, 2024	STONEPINE CAPITAL MANAGEMENT, LLC	0.33%	141.55K	332.64K	141.55K	+100.00%
Mar 31, 2024	EXCHANGE TRADED CONCEPTS, LLC	0.32%	138.99K	326.63K	57.01K	+69.53%
Mar 31, 2024	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.3%	129.8K	305.03K	75K	+136.86%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.25%	109.24K	256.72K	109.24K	+100.00%
Mar 31, 2024	CUBIST SYSTEMATIC STRATEGIES, LLC	0.11%	45.95K	107.99K	26.42K	+135.24%
Mar 31, 2024	ORBIMED ADVISORS LLC	26.59%	11.45M	26.9M	3.13M	+37.55%
Mar 31, 2024	RA CAPITAL MANAGEMENT, L.P.	17.52%	7.54M	17.72M	7.54M	+100.00%
Mar 31, 2024	TANG CAPITAL MANAGEMENT LLC	14.89%	6.41M	15.06M	5.53M	+631.14%
Mar 31, 2024	RTW INVESTMENTS, LP	9.61%	4.13M	9.72M	0	0
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	9.54%	4.11M	9.65M	2.78M	+210.70%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	9.31%	4.01M	9.41M	3.98M	+13,899.19%
Mar 31, 2024	VANGUARD GROUP INC	7.26%	3.13M	7.35M	1.44M	+85.55%
Mar 31, 2024	COMMODORE CAPITAL LP	3.19%	1.37M	3.23M	1.37M	+100.00%
Mar 31, 2024	BLACKSTONE INC.	2.87%	1.24M	2.91M	1.24M	+100.00%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	2.8%	1.2M	2.83M	543.17K	+82.07%
Mar 31, 2024	SCHONFELD STRATEGIC ADVISORS LLC	2.64%	1.13M	2.67M	934.3K	+466.92%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	2.44%	1.05M	2.47M	282.4K	+36.84%
Mar 31, 2024	STATE STREET CORP	2.18%	940.23K	2.21M	299.69K	+46.79%
Mar 31, 2024	COWEN AND COMPANY, LLC	2%	860.14K	2.02M	-1.86M	-68.32%
Mar 31, 2024	OCTAGON CAPITAL ADVISORS LP	1.78%	767.8K	1.8M	767.8K	+100.00%
Dec 31, 2023	EXCHANGE TRADED CONCEPTS, LLC	0.19%	81.99K	154.95K	20.79K	+33.97%
Dec 31, 2023	SG AMERICAS SECURITIES, LLC	0.04%	16K	30K	2.78K	+21.03%
Dec 31, 2023	SIMPLEX TRADING, LLC	0.04%	16.54K	31K	1.59K	+10.67%
Dec 31, 2023	SUMMIT TRAIL ADVISORS, LLC	0.04%	18K	34.02K	0	0
Dec 31, 2023	CUBIST SYSTEMATIC STRATEGIES, LLC	0.05%	19.54K	36.92K	-12.21K	-38.46%
Dec 31, 2023	JPMORGAN CHASE & CO	0.05%	19.83K	37.48K	-8.15K	-29.12%
Dec 31, 2023	GSA CAPITAL PARTNERS LLP	0.05%	20.67K	39K	-121.49K	-85.46%
Dec 31, 2023	UBS GROUP AG	0.05%	22.58K	42.67K	18.24K	+420.59%
Dec 31, 2023	XTX TOPCO LTD	0.05%	23K	43.47K	-32.61K	-58.64%
Dec 31, 2023	JANE STREET GROUP, LLC	0.05%	23.01K	43.49K	23.01K	+100.00%
Dec 31, 2023	SQUAREPOINT OPS LLC	0.07%	28.24K	53.37K	1.83K	+6.91%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.07%	28.61K	54.08K	-30.9K	-51.92%
Dec 31, 2023	SEI INVESTMENTS CO	0.07%	31.01K	58.61K	31.01K	+100.00%
Dec 31, 2023	ALLIANCEBERNSTEIN L.P.	0.09%	36.74K	69.44K	-3.8K	-9.37%
Dec 31, 2023	CORNERCAP INVESTMENT COUNSEL INC	0.09%	38.21K	72.22K	0	0
Dec 31, 2023	BARCLAYS PLC	0.1%	41.8K	79K	36.33K	+664.67%
Dec 31, 2023	DEUTSCHE BANK AG\	0.11%	45.71K	86.38K	40.09K	+713.56%
Dec 31, 2023	RHUMBLINE ADVISERS	0.11%	47.12K	89.04K	657	+1.41%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.11%	47.74K	90.24K	2.31K	+5.08%
Dec 31, 2023	PANAGORA ASSET MANAGEMENT INC	0.12%	51.75K	97.8K	51.75K	+100.00%
Dec 31, 2023	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.13%	54.8K	103.57K	-194.4K	-78.01%
Dec 31, 2023	PRUDENTIAL FINANCIAL INC	0.14%	59.65K	112.74K	0	0
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.16%	69.46K	131.28K	0	0
Dec 31, 2023	OCCUDO QUANTITATIVE STRATEGIES LP	0.18%	76.28K	144.17K	-4.85K	-5.98%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.23%	97.54K	184.35K	-33.85K	-25.77%
Dec 31, 2023	CITADEL ADVISORS LLC	0.04%	17.4K	32.89K	-3.3K	-15.94%
Dec 31, 2023	FMR LLC	0.32%	135.91K	256.88K	-84	-0.06%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	0.36%	153.41K	289.64K	-7.49K	-4.66%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.45%	193.8K	366.29K	31.01K	+19.05%
Dec 31, 2023	SCHONFELD STRATEGIC ADVISORS LLC	0.47%	200.1K	378.19K	200.1K	+100.00%
Dec 31, 2023	NORTHERN TRUST CORP	0.54%	232.09K	438.64K	1.68K	+0.73%
Dec 31, 2023	D. E. SHAW & CO., INC.	0.81%	346.62K	655.11K	101.75K	+41.55%
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	0.84%	360.73K	681.77K	135.41K	+60.10%
Dec 31, 2023	NORGES BANK	1%	429.55K	811.85K	429.55K	+100.00%
Dec 31, 2023	TWO SIGMA ADVISERS, LP	1.21%	520.04K	982.87K	133.34K	+34.48%
Dec 31, 2023	ACADIAN ASSET MANAGEMENT LLC	1.3%	559.75K	1.06M	36.74K	+7.02%
Dec 31, 2023	STATE STREET CORP	1.49%	640.54K	1.21M	7.01K	+1.11%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.54%	661.8K	1.25M	28.84K	+4.56%
Dec 31, 2023	JOHNSON & JOHNSON	1.6%	688.6K	1.3M	-40.35K	-5.54%
Dec 31, 2023	RENAISSANCE TECHNOLOGIES LLC	1.78%	766.6K	1.45M	89.6K	+13.23%
Dec 31, 2023	TANG CAPITAL MANAGEMENT LLC	2.04%	876.35K	1.66M	-350K	-28.54%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	3.07%	1.32M	2.5M	427.71K	+47.85%
Dec 31, 2023	VANGUARD GROUP INC	3.92%	1.69M	3.18M	12.69K	+0.76%
Dec 31, 2023	CARLYLE GROUP INC.	4.92%	2.12M	3.98M	0	0
Dec 31, 2023	BLACKROCK INC.	5.08%	2.18M	4.13M	-86.8K	-3.82%
Dec 31, 2023	COWEN AND COMPANY, LLC	6.32%	2.72M	5.13M	0	0
Dec 31, 2023	MORGAN STANLEY	6.51%	2.8M	5.29M	-1.04M	-27.05%
Dec 31, 2023	RTW INVESTMENTS, LP	9.62%	4.13M	7.81M	-106.84K	-2.52%
Dec 31, 2023	ORBIMED ADVISORS LLC	19.36%	8.32M	15.73M	0	0
Sep 30, 2023	RTW INVESTMENTS, LP	9.87%	4.24M	-	0	0
Sep 30, 2023	ROYAL BANK OF CANADA	0.01%	5.1K	-	1.93K	+60.64%
Sep 30, 2023	BARCLAYS PLC	0.01%	5.47K	-	-224.69K	-97.63%
Sep 30, 2023	GROUP ONE TRADING, L.P.	0.01%	5.49K	-	5.49K	+100.00%
Sep 30, 2023	DEUTSCHE BANK AG\	0.01%	5.62K	-	-1.02M	-99.45%
Sep 30, 2023	QUANTBOT TECHNOLOGIES LP	0.01%	6.1K	-	-6K	-49.59%
Sep 30, 2023	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0.02%	6.71K	-	-3.4K	-33.67%
Sep 30, 2023	WELLS FARGO & COMPANY/MN	0.02%	7.53K	-	-4.06K	-35.01%
Sep 30, 2023	TOWER RESEARCH CAPITAL LLC (TRC)	0.03%	10.91K	-	-406	-3.59%
Sep 30, 2023	POINT72 MIDDLE EAST FZE	0.03%	11.39K	-	11.39K	+100.00%
Sep 30, 2023	NEW YORK STATE COMMON RETIREMENT FUND	0.03%	11.73K	-	119	+1.02%
Sep 30, 2023	BALYASNY ASSET MANAGEMENT L.P.	0.03%	12.55K	-	12.55K	+100.00%
Sep 30, 2023	PRINCIPAL FINANCIAL GROUP INC	0.03%	12.7K	-	0	0
Sep 30, 2023	SG AMERICAS SECURITIES, LLC	0.03%	13.22K	-	13.22K	+100.00%
Sep 30, 2023	SIMPLEX TRADING, LLC	0.03%	14.95K	-	14.21K	+1,930.71%
Sep 30, 2023	AMERICAN INTERNATIONAL GROUP, INC.	0.04%	15.17K	-	539	+3.68%
Sep 30, 2023	SUMMIT TRAIL ADVISORS, LLC	0.04%	18K	-	8K	+80.00%
Sep 30, 2023	AMERICAN CENTURY COMPANIES INC	0.05%	21.79K	-	4.85K	+28.61%
Sep 30, 2023	MARQUETTE ASSET MANAGEMENT, LLC	0.07%	28.14K	-	28.14K	+100.00%
Sep 30, 2023	CUBIST SYSTEMATIC STRATEGIES, LLC	0.07%	31.75K	-	31.75K	+100.00%
Sep 30, 2023	CORNERCAP INVESTMENT COUNSEL INC	0.09%	38.21K	-	-481	-1.24%
Sep 30, 2023	ALLIANCEBERNSTEIN L.P.	0.09%	40.54K	-	0	0
Sep 30, 2023	RHUMBLINE ADVISERS	0.11%	46.46K	-	-563	-1.20%
Sep 30, 2023	XTX TOPCO LTD	0.13%	55.61K	-	13.46K	+31.92%
Sep 30, 2023	GOLDMAN SACHS GROUP INC	0.14%	59.51K	-	-10.48K	-14.97%
Sep 30, 2023	ORBIMED ADVISORS LLC	19.37%	8.32M	-	0	0
Sep 30, 2023	PRUDENTIAL FINANCIAL INC	0.14%	59.65K	-	0	0
Sep 30, 2023	EXCHANGE TRADED CONCEPTS, LLC	0.14%	61.2K	-	31.71K	+107.51%
Sep 30, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.16%	69.46K	-	-13.24K	-16.01%
Sep 30, 2023	OCCUDO QUANTITATIVE STRATEGIES LP	0.19%	81.13K	-	-62.41K	-43.48%
Sep 30, 2023	BANK OF NEW YORK MELLON CORP	0.31%	131.39K	-	30.53K	+30.27%
Sep 30, 2023	FMR LLC	0.32%	136K	-	64.93K	+91.37%
Sep 30, 2023	ACUITAS INVESTMENTS, LLC	0.32%	136.78K	-	136.78K	+100.00%
Sep 30, 2023	GSA CAPITAL PARTNERS LLP	0.33%	142.17K	-	37.19K	+35.43%
Sep 30, 2023	DIMENSIONAL FUND ADVISORS LP	0.37%	160.91K	-	-168K	-51.08%
Sep 30, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.38%	162.79K	-	-964	-0.59%
Sep 30, 2023	DECHENG CAPITAL MANAGEMENT III (CAYMAN), LLC	0.47%	200.2K	-	-305.47K	-60.41%
Sep 30, 2023	TWO SIGMA INVESTMENTS, LP	0.52%	225.32K	-	70.68K	+45.71%
Sep 30, 2023	NORTHERN TRUST CORP	0.54%	230.4K	-	-11.6K	-4.79%
Sep 30, 2023	D. E. SHAW & CO., INC.	0.57%	244.87K	-	213.42K	+678.51%
Sep 30, 2023	JACOBS LEVY EQUITY MANAGEMENT, INC	0.78%	333.59K	-	9.44K	+2.91%
Sep 30, 2023	TWO SIGMA ADVISERS, LP	0.9%	386.7K	-	281.9K	+269.00%
Sep 30, 2023	ACADIAN ASSET MANAGEMENT LLC	1.22%	523.01K	-	500.1K	+2,182.49%
Sep 30, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.47%	632.95K	-	-15	0.00%
Sep 30, 2023	JOHNSON & JOHNSON	1.7%	728.94K	-	0	0
Sep 30, 2023	DAFNA CAPITAL MANAGEMENT LLC	1.86%	797.05K	-	0	0
Sep 30, 2023	CARLYLE GROUP INC.	4.92%	2.12M	-	0	0
Sep 30, 2023	BLACKROCK INC.	5.28%	2.27M	-	-118.23K	-4.95%
Sep 30, 2023	COWEN AND COMPANY, LLC	6.32%	2.72M	-	-119.59K	-4.22%
Sep 30, 2023	MORGAN STANLEY	8.93%	3.84M	-	1.39M	+56.72%

Insiders

Among the ACET insiders holding of 1.46% of the stake in company, SILVERSTEIN JONATHAN, , holds the largest shares of 4.83M. ORBIMED ADVISORS LLC, 10 percent owner, is the second largest ACET insider with ownership of 4.49M shares. SINCLAIR ANDREW, director, stands third with possession of 2.14M shares of that stake.

Insiders	Designation	Shares Held
SILVERSTEIN JONATHAN		4.83M
ORBIMED ADVISORS LLC	10 percent owner	4.49M
SINCLAIR ANDREW	director	2.14M
PURETECH HEALTH LLC	10 percent owner	2.12M
GORDON CARL L		990.25K
JAKOBOVITS AYA		356.35K
HEALEY DON	Chief Technology Officer	66.57K
GALIMI FRANCESCO	SVP & Chief Medical Officer	59.92K
SCHOR CHEN	President & CEO	43.47K
AFTAB BLAKE	Chief Scientific Officer	28.21K
DUBIN STEVE	director	10.9K
GIORDANO NATASHA	director	8.06K
KAUFFMAN MICHAEL	director	5.9K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Oct 08, 2025	ORBIMED ADVISORS LLC	PURCHASE	1.00	3.5M	3.5M	4.49M
Jun 05, 2024	KAUFFMAN MICHAEL	SALE	1.43	5.9K	8.44K	5.9K
Jan 25, 2024	GORDON CARL L	PURCHASE	2.40	242.2K	581.28K	990.25K
Jan 25, 2024	ORBIMED ADVISORS LLC	PURCHASE	2.40	242.2K	581.28K	990.25K
Oct 02, 2023	SCHOR CHEN	PURCHASE	1.33	5.5K	7.34K	43.47K
Sep 29, 2023	SCHOR CHEN	SALE	1.36	5.5K	7.48K	176.97K
Sep 28, 2023	SCHOR CHEN	SALE	1.42	5.5K	7.81K	37.97K
Jun 30, 2023	DUBIN STEVE	PURCHASE	2.40	5K	12K	10.9K
Jun 27, 2023	ORBIMED ADVISORS LLC	PURCHASE	2.09	250K	522.5K	646.66K
Jun 27, 2023	GORDON CARL L	PURCHASE	2.09	250K	522.5K	646.66K
Feb 15, 2023	HEALEY DON	SALE	7.57	4.53K	34.33K	66.57K
Feb 10, 2023	HEALEY DON	SALE	7.98	10.47K	83.48K	71.1K
Nov 10, 2022	SCHOR CHEN	SALE	20.06	30K	601.92K	53.42K
Nov 10, 2022	AFTAB BLAKE	SALE	21.00	6.97K	146.31K	28.21K
Nov 07, 2022	SCHOR CHEN	SALE	19.05	30K	571.49K	83.42K
Nov 03, 2022	SCHOR CHEN	SALE	18.04	24.81K	447.72K	113.42K
Nov 02, 2022	SCHOR CHEN	SALE	18.00	500	9K	138.24K
Oct 19, 2022	AFTAB BLAKE	SALE	16.27	8.07K	131.25K	35.18K
Oct 12, 2022	AFTAB BLAKE	SALE	15.40	1.65K	25.35K	51.18K
Sep 14, 2022	SCHOR CHEN	SALE	18.00	952	17.14K	138.74K
Sep 13, 2022	SCHOR CHEN	SALE	18.01	3.37K	60.71K	139.69K
Sep 12, 2022	SCHOR CHEN	SALE	16.77	66.75K	1.12M	0
Sep 09, 2022	SCHOR CHEN	SALE	16.51	8.09K	133.6K	66.75K
Aug 03, 2022	AFTAB BLAKE	SALE	18.00	6.97K	125.42K	38.97K
Aug 01, 2022	AFTAB BLAKE	SALE	16.64	6.97K	115.95K	45.94K
Jul 05, 2022	AFTAB BLAKE	SALE	14.50	1.36K	19.76K	52.9K
Apr 01, 2022	GALIMI FRANCESCO	SALE	21.00	1.78K	37.28K	59.92K
Mar 09, 2022	JAKOBOVITS AYA	SALE	14.00	2K	28K	356.35K
Feb 16, 2022	JAKOBOVITS AYA	SALE	14.83	2K	29.66K	358.34K
Feb 09, 2022	JAKOBOVITS AYA	SALE	14.03	4K	56.12K	360.34K
Jan 05, 2022	JAKOBOVITS AYA	SALE	16.93	2K	33.86K	364.34K
Jan 03, 2022	JAKOBOVITS AYA	SALE	18.02	6K	108.12K	366.34K
Dec 08, 2021	SINCLAIR ANDREW	PURCHASE	14.00	500K	7M	2.14M
Jun 16, 2021	SCHOR CHEN	SALE	10.53	7.48K	78.83K	74.84K
Jun 15, 2021	JAKOBOVITS AYA	SALE	11.16	1.92K	21.45K	215.88K
Jun 03, 2021	SCHOR CHEN	SALE	12.06	7.48K	90.22K	82.33K
May 20, 2021	JAKOBOVITS AYA	SALE	14.23	900	12.81K	217.81K
May 19, 2021	SCHOR CHEN	SALE	13.73	612	8.4K	89.81K
May 18, 2021	JAKOBOVITS AYA	SALE	14.05	3.11K	43.68K	218.7K
May 12, 2021	JAKOBOVITS AYA	SALE	13.24	5K	66.2K	221.81K
May 05, 2021	SCHOR CHEN	SALE	14.70	3.06K	44.95K	97.29K
Apr 20, 2021	SCHOR CHEN	SALE	12.01	7.48K	89.85K	104.78K
Apr 06, 2021	SCHOR CHEN	SALE	13.04	7.48K	97.58K	112.26K
Mar 30, 2021	SCHOR CHEN	SALE	13.22	4.5K	59.49K	119.75K
Mar 16, 2021	SCHOR CHEN	SALE	15.66	2.09K	32.71K	127.23K
Dec 18, 2019	PURETECH HEALTH LLC	SALE	1.20	6.16M	7.39M	2.12M
Dec 13, 2019	PURETECH HEALTH LLC	SALE	1.24	205.76K	255.8K	8.28M
Dec 12, 2019	PURETECH HEALTH LLC	SALE	1.25	385.88K	482.32K	8.49M
Dec 11, 2019	PURETECH HEALTH LLC	SALE	1.25	59.92K	74.9K	8.87M
Dec 10, 2019	PURETECH HEALTH LLC	SALE	1.26	336.56K	423.66K	8.93M
Nov 15, 2019	PURETECH HEALTH LLC	SALE	1.25	531.04K	661.94K	9.27M
Apr 16, 2018	SCHOR CHEN	PURCHASE	8.95	2K	17.91K	1.89M
Apr 11, 2018	SCHOR CHEN	PURCHASE	9.36	2K	18.72K	1.89M
Apr 10, 2018	SCHOR CHEN	PURCHASE	8.46	2K	16.91K	1.89M
Jan 30, 2018	ORBIMED ADVISORS LLC	PURCHASE	15.00	533.33K	8M	4.83M
Jan 30, 2018	SILVERSTEIN JONATHAN	PURCHASE	15.00	533.33K	8M	4.83M
Jan 30, 2018	PURETECH HEALTH LLC	PURCHASE	15.00	233.33K	3.5M	9.8M
Mar 04, 2015	GIORDANO NATASHA	SALE	20.92	2.16K	45.28K	8.06K
Sep 09, 2014	GIORDANO NATASHA	SALE	21.94	1.45K	31.88K	8.05K
Jun 06, 2014	GIORDANO NATASHA	SALE	17.28	1.16K	20.04K	9.51K
Jun 02, 2014	GIORDANO NATASHA	SALE	17.43	1.15K	20.03K	10.67K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE3.5M1

SALES00

NET SHARES3.5M1

SHARES HELD4.49M1

% NET SHARES-22.05%0%

Frequently Asked Questions

Stock Outstanding Shares

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares0.61

Short Percent Of Float0.72

Shares Outstanding153.26M

Shares Float8.41M

Shares Short931.91K

Short Ratio6.16

0.72%

Short % of Float

0.61%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

1.46% Percentage of Shares held by All Insiders

36.36% Percentage of Shares held by All Institutions

36.9% Percentage of Float held by Institutions

Number of Institutions Holding Shares

Institutional Ownership

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	REGENERON PHARMACEUTICALS, INC.	1.06%	968.18K	784.42K	0	0
Sep 30, 2025	VANGUARD GROUP INC	3.59%	3.27M	2.65M	0	0
Sep 30, 2025	FMR LLC	0%	776	629	-244K	-99.68%
Sep 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.02%	20.26K	16.41K	300	+1.50%
Sep 30, 2025	RIGGS ASSET MANAGMENT CO. INC.	0%	0	-	-1.12K	-100.00%
Sep 30, 2025	UBS GROUP AG	0.02%	21.44K	17.37K	2.93K	+15.83%
Sep 30, 2025	ABACUS PLANNING GROUP, INC.	0.04%	36.76K	29.79K	0	0
Sep 30, 2025	VIRTU FINANCIAL LLC	0.09%	79.92K	65K	79.92K	+100.00%
Sep 30, 2025	XTX TOPCO LTD	0.06%	58.14K	47.1K	34.56K	+146.56%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.06%	52.96K	42.91K	-4.31K	-7.52%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.04%	40.37K	32.71K	40.37K	+100.00%
Sep 30, 2025	HRT FINANCIAL LP	0.02%	18.63K	15K	18.63K	+100.00%
Sep 30, 2025	RAYMOND JAMES FINANCIAL INC	0.01%	13.27K	10.75K	9.51K	+253.54%
Sep 30, 2025	TOWER RESEARCH CAPITAL LLC (TRC)	0.01%	4.99K	4.05K	-24.07K	-82.82%
Sep 30, 2025	HOLLENCREST CAPITAL MANAGEMENT	0%	2K	1.62K	0	0
Sep 30, 2025	SBI SECURITIES CO., LTD.	0%	827	670	5	+0.61%
Sep 30, 2025	LANDSCAPE CAPITAL MANAGEMENT, L.L.C.	0%	0	-	-17.85K	-100.00%
Sep 30, 2025	LUMINUS MANAGEMENT LLC	0%	0	-	-289.94K	-100.00%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0%	0	-	-30K	-100.00%
Sep 30, 2025	CITIGROUP INC	0%	166	134	-542	-76.55%
Sep 30, 2025	VONTOBEL HOLDING LTD.	0.09%	80K	65.18K	0	0
Sep 30, 2025	TWO SIGMA SECURITIES, LLC	0.03%	25.27K	20.48K	25.27K	+100.00%
Sep 30, 2025	JPMORGAN CHASE & CO	0%	771	625	0	0
Sep 30, 2025	MARSHALL WACE, LLP	0.06%	51.73K	41.9K	51.73K	+100.00%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	2.01%	1.83M	1.48M	675.13K	+58.51%
Sep 30, 2025	CARLYLE GROUP INC.	3.24%	2.95M	2.39M	0	0
Sep 30, 2025	ACADIAN ASSET MANAGEMENT LLC	2.49%	2.27M	1.84M	190.89K	+9.20%
Sep 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.72%	655.67K	531.22K	0	0
Sep 30, 2025	CITADEL ADVISORS LLC	0.64%	583.95K	473.12K	123.54K	+26.83%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.62%	565.95K	458.54K	-26.37K	-4.45%
Sep 30, 2025	WEALTHEDGE INVESTMENT ADVISORS, LLC	0.33%	300.05K	243.1K	-13.05K	-4.17%
Sep 30, 2025	BARCLAYS PLC	0.33%	300K	243.06K	150K	+100.00%
Sep 30, 2025	STATE STREET CORP	0.27%	244.19K	197.84K	-2.74K	-1.11%
Sep 30, 2025	JANE STREET GROUP, LLC	0.2%	186.2K	150.86K	186.2K	+100.00%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.02%	20.61K	16.69K	-28	-0.14%
Sep 30, 2025	RANGELEY CAPITAL, LLC	0.08%	75K	60.77K	75K	+100.00%
Sep 30, 2025	MARINER, LLC	0.02%	14.85K	12.03K	14.85K	+100.00%
Sep 30, 2025	ORBIMED ADVISORS LLC	12.57%	11.45M	9.27M	0	0
Sep 30, 2025	TANG CAPITAL MANAGEMENT LLC	9.03%	8.22M	6.66M	0	0
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	8.28%	7.54M	6.11M	0	0
Sep 30, 2025	GOLDMAN SACHS GROUP INC	4.12%	3.75M	3.04M	-481	-0.01%
Sep 30, 2025	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.99%	901.6K	730.48K	0	0
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.94%	854.57K	692.37K	341.76K	+66.65%
Sep 30, 2025	TWO SIGMA ADVISERS, LP	0.86%	780.98K	632.75K	214.94K	+37.97%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.78%	706.33K	572.44K	0	0
Sep 30, 2025	RBF CAPITAL, LLC	0.68%	617.32K	500.15K	0	0
Sep 30, 2025	BLACKROCK, INC.	0.64%	585.38K	474.27K	-14.11K	-2.35%
Sep 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.53%	479.11K	388.17K	-1.4M	-74.52%
Sep 30, 2025	ADVISOR GROUP HOLDINGS, INC.	0%	10	7	10	+100.00%
Sep 30, 2025	DAFNA CAPITAL MANAGEMENT LLC	0%	0	-	-540K	-100.00%
Sep 30, 2025	JOHNSON & JOHNSON	0.4%	364.47K	295.3K	0	0
Sep 30, 2025	MORGAN STANLEY	0.08%	73.68K	59.7K	1.46K	+2.02%
Sep 30, 2025	SQUAREPOINT OPS LLC	0.05%	46.43K	37.62K	46.43K	+100.00%
Sep 30, 2025	TOTH FINANCIAL ADVISORY CORP	0%	1.6K	1.3K	0	0
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0%	896	726	0	0
Sep 30, 2025	NORTHERN TRUST CORP	0.15%	140.37K	113.73K	0	0
Sep 30, 2025	ROYAL BANK OF CANADA	0.09%	80.11K	65K	80.11K	+100.00%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.02%	20.64K	12.59K	94	+0.46%
Jun 30, 2025	SIMPLEX TRADING, LLC	0%	0	-	-1.86K	-100.00%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.65%	592.33K	361.32K	-631.54K	-51.60%
Jun 30, 2025	SBI SECURITIES CO., LTD.	0%	822	501	58	+7.59%
Jun 30, 2025	WEALTHEDGE INVESTMENT ADVISORS, LLC	0.34%	313.11K	191K	85.31K	+37.45%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.06%	57.27K	34.93K	-90.55K	-61.26%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.03%	30K	18.3K	0	0
Jun 30, 2025	TOWER RESEARCH CAPITAL LLC (TRC)	0.03%	29.06K	17.73K	10.77K	+58.90%
Jun 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.02%	19.96K	12.17K	-33.88K	-62.93%
Jun 30, 2025	ORBIMED ADVISORS LLC	12.57%	11.45M	6.98M	0	0
Jun 30, 2025	LANDSCAPE CAPITAL MANAGEMENT, L.L.C.	0.02%	17.85K	10.89K	17.85K	+100.00%
Jun 30, 2025	HOLLENCREST CAPITAL MANAGEMENT	0%	2K	1.22K	1.1K	+122.22%
Jun 30, 2025	TOTH FINANCIAL ADVISORY CORP	0%	1.6K	976	1.6K	+100.00%
Jun 30, 2025	SQUAREPOINT OPS LLC	0%	0	-	-11.57K	-100.00%
Jun 30, 2025	POINT72 ASIA (SINGAPORE) PTE. LTD.	0%	0	-	-13.47K	-100.00%
Jun 30, 2025	POINT72 (DIFC) LTD	0%	0	-	-95	-100.00%
Jun 30, 2025	ABACUS PLANNING GROUP, INC.	0.04%	36.76K	22.43K	36.76K	+100.00%
Jun 30, 2025	XTX TOPCO LTD	0.03%	23.58K	14.38K	23.58K	+100.00%
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	2.06%	1.88M	1.15M	1.88M	+100.00%
Jun 30, 2025	REGENERON PHARMACEUTICALS, INC.	1.06%	968.18K	590.59K	0	0
Jun 30, 2025	STONEPINE CAPITAL MANAGEMENT, LLC	0%	0	-	-508.27K	-100.00%
Jun 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0%	896	547	2	+0.22%
Jun 30, 2025	COLDSTREAM CAPITAL MANAGEMENT INC	0%	0	-	-8.88K	-100.00%
Jun 30, 2025	CITIGROUP INC	0%	708	432	-1.58K	-69.08%
Jun 30, 2025	RIGGS ASSET MANAGMENT CO. INC.	0%	1.12K	685	1.12K	+100.00%
Jun 30, 2025	RAYMOND JAMES FINANCIAL INC	0%	3.75K	2.29K	3.75K	+100.00%
Jun 30, 2025	TWO SIGMA ADVISERS, LP	0.62%	566.04K	345.28K	-56.8K	-9.12%
Jun 30, 2025	FMR LLC	0.27%	244.78K	149.32K	-4.21K	-1.69%
Jun 30, 2025	STATE STREET CORP	0.27%	246.92K	150.62K	0	0
Jun 30, 2025	JOHNSON & JOHNSON	0.4%	364.47K	228.01K	0	0
Jun 30, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.59%	540K	329.4K	-60K	-10.00%
Jun 30, 2025	RBF CAPITAL, LLC	0.68%	617.32K	376.57K	0	0
Jun 30, 2025	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.99%	901.6K	549.98K	0	0
Jun 30, 2025	ACADIAN ASSET MANAGEMENT LLC	2.28%	2.07M	1.26M	35.28K	+1.73%
Jun 30, 2025	CARLYLE GROUP INC.	3.24%	2.95M	1.8M	0	0
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	8.28%	7.54M	4.6M	0	0
Jun 30, 2025	TANG CAPITAL MANAGEMENT LLC	9.03%	8.22M	5.02M	0	0
Jun 30, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0%	0	-	-12.4K	-100.00%
Jun 30, 2025	JANE STREET GROUP, LLC	0%	0	-	-16.3K	-100.00%
Jun 30, 2025	GROUND SWELL CAPITAL, LLC	0%	0	-	-15.95K	-100.00%
Jun 30, 2025	VIRTU FINANCIAL LLC	0%	0	-	-23.73K	-100.00%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	4.12%	3.75M	2.29B	-64.46K	-1.69%
Jun 30, 2025	VANGUARD GROUP INC	3.59%	3.27M	2M	66.64K	+2.08%
Jun 30, 2025	MORGAN STANLEY	0.08%	72.23K	44.06M	70.54K	+4,191.50%
Jun 30, 2025	CITADEL ADVISORS LLC	0.03%	27.2K	16.59M	-9.7K	-26.29%
Jun 30, 2025	D. E. SHAW & CO., INC.	0.02%	22.2K	13.54M	-483.27K	-95.61%
Jun 30, 2025	UBS GROUP AG	0.02%	18.51K	11.29K	-45.53K	-71.10%
Jun 30, 2025	VONTOBEL HOLDING LTD.	0.09%	80K	48.8K	20K	+33.33%
Jun 30, 2025	BLACKSTONE INC.	0%	0	-	-1.24M	-100.00%
Jun 30, 2025	CAXTON CORP	0%	0	-	-17.49K	-100.00%
Jun 30, 2025	PRELUDE CAPITAL MANAGEMENT, LLC	0%	0	-	-34.25K	-100.00%
Jun 30, 2025	THOMPSON INVESTMENT MANAGEMENT, INC.	0%	0	-	-80	-100.00%
Jun 30, 2025	GROUP ONE TRADING, L.P.	0%	0	-	-6.79K	-100.00%
Jun 30, 2025	STONEX GROUP INC.	0%	0	-	-12.45K	-100.00%
Jun 30, 2025	JPMORGAN CHASE & CO	0%	771	470	-399	-34.10%
Jun 30, 2025	BLACKROCK, INC.	0.66%	599.49K	365.69K	-149.58K	-19.97%
Jun 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.72%	655.67K	399.96K	0	0
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.78%	706.33K	430.98K	-64.37K	-8.35%
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	1.27%	1.15M	703.83K	343.12K	+42.32%
Jun 30, 2025		0%	822	501	58	+7.59%
Jun 30, 2025	NORTHERN TRUST CORP	0.15%	140.37K	85.63K	0	0
Jun 30, 2025	BARCLAYS PLC	0.16%	150K	92K	150K	+100.00%
Jun 30, 2025	LUMINUS MANAGEMENT LLC	0.32%	289.94K	176.86K	289.94K	+100.00%
Jun 30, 2025	TWO SIGMA INVESTMENTS, LP	0.56%	512.81K	312.81K	17.83K	+3.60%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.89%	810.7K	612.08K	-105.8K	-11.54%
Mar 31, 2025	CAXTON CORP	0.02%	17.49K	13.2K	0	0
Mar 31, 2025	TOWER RESEARCH CAPITAL LLC (TRC)	0.02%	18.29K	13.81K	18.29K	+100.00%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.02%	20.54K	15.51K	-16.82K	-45.02%
Mar 31, 2025	VIRTU FINANCIAL LLC	0.03%	23.73K	18K	-6.88K	-22.49%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	4.19%	3.82M	2.88M	63.69K	+1.70%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.03%	30K	22.65K	0	0
Mar 31, 2025	PRELUDE CAPITAL MANAGEMENT, LLC	0.04%	34.25K	25.86K	5.34K	+18.46%
Mar 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.06%	53.83K	40.65K	-82.27K	-60.45%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.54%	494.98K	373.71K	-208.38K	-29.63%
Mar 31, 2025	CITIGROUP INC	0%	2.29K	1.73K	2.05K	+846.28%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.5%	457.72K	345.58K	-19.95K	-4.18%
Mar 31, 2025	TWO SIGMA ADVISERS, LP	0.68%	622.84K	470.24K	-171.2K	-21.56%
Mar 31, 2025	BLACKROCK, INC.	0.82%	749.07K	565.55K	-62.71K	-7.72%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.85%	770.7K	582.06K	3.16K	+0.41%
Mar 31, 2025	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.99%	901.6K	680.71K	-125K	-12.18%
Mar 31, 2025	BLACKSTONE INC.	1.36%	1.24M	933.52K	0	0
Mar 31, 2025	VONTOBEL HOLDING LTD.	0.07%	60K	46.59K	10K	+20.00%
Mar 31, 2025	NORTHERN TRUST CORP	0.15%	140.37K	105.98K	4	0.00%
Mar 31, 2025	VANGUARD GROUP INC	3.52%	3.21M	2.42M	0	0
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	8.28%	7.54M	5.69M	0	0
Mar 31, 2025	GROUP ONE TRADING, L.P.	0.01%	6.79K	5.13K	-4.41K	-39.36%
Mar 31, 2025	COLDSTREAM CAPITAL MANAGEMENT INC	0.01%	8.88K	6.7K	8.88K	+100.00%
Mar 31, 2025	ORBIMED ADVISORS LLC	12.57%	11.45M	8.64M	0	0
Mar 31, 2025	TANG CAPITAL MANAGEMENT LLC	9.03%	8.22M	6.21M	77.62K	+0.95%
Mar 31, 2025	UBS GROUP AG	0.07%	64.04K	48.35K	-139.19K	-68.49%
Mar 31, 2025	JOHNSON & JOHNSON	0.4%	364.47K	275.18K	0	0
Mar 31, 2025	GROUND SWELL CAPITAL, LLC	0.02%	15.95K	12.04K	15.95K	+100.00%
Mar 31, 2025	JANE STREET GROUP, LLC	0.02%	16.3K	12.31K	3.99K	+32.38%
Mar 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.72%	655.67K	495.03K	0	0
Mar 31, 2025	REGENERON PHARMACEUTICALS, INC.	1.06%	968.18K	730.98K	0	0
Mar 31, 2025		0.25%	227.8K	171.99K	154.04K	+208.82%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	1.34%	1.22M	924.02K	-590.45K	-32.54%
Mar 31, 2025	ACADIAN ASSET MANAGEMENT LLC	2.24%	2.04M	1.54M	36.28K	+1.81%
Mar 31, 2025	AQUILO CAPITAL MANAGEMENT, LLC	2.7%	2.46M	1.85M	-75K	-2.96%
Mar 31, 2025	CARLYLE GROUP INC.	3.24%	2.95M	2.28M	0	0
Mar 31, 2025	STONEPINE CAPITAL MANAGEMENT, LLC	0.56%	508.27K	203.5K	-191.73K	-27.39%
Mar 31, 2025	SQUAREPOINT OPS LLC	0.01%	11.57K	8.73K	-172.79K	-93.73%
Mar 31, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0.01%	12.4K	9.36K	-118	-0.94%
Mar 31, 2025	STONEX GROUP INC.	0.01%	12.45K	9.4K	12.45K	+100.00%
Mar 31, 2025	POINT72 ASIA (SINGAPORE) PTE. LTD.	0.01%	13.47K	10.17K	-26.52K	-66.32%
Mar 31, 2025	CITADEL ADVISORS LLC	0.02%	16.5K	12.46K	-12.2K	-42.51%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.16%	147.81K	111.76K	0	0
Mar 31, 2025	STATE STREET CORP	0.27%	246.92K	186.43K	0	0
Mar 31, 2025	FMR LLC	0.27%	248.99K	187.99K	-56.92K	-18.61%
Mar 31, 2025	D. E. SHAW & CO., INC.	0.56%	505.47K	381.63K	-341.6K	-40.33%
Mar 31, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.66%	600K	453K	0	0
Mar 31, 2025	RBF CAPITAL, LLC	0.68%	617.32K	466.08K	16.18K	+2.69%
Mar 31, 2024	CARLYLE GROUP INC.	6.85%	2.95M	6.9M	833.33K	+39.39%
Mar 31, 2024	CORNERCAP INVESTMENT COUNSEL INC	0.09%	38.21K	89.79K	0	0
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.09%	36.74K	86.34K	0	0
Mar 31, 2024	VONTOBEL HOLDING LTD.	0.06%	27K	63.45K	27K	+100.00%
Mar 31, 2024	AMERICAN INTERNATIONAL GROUP, INC.	0.06%	26.32K	61.85K	11.21K	+74.24%
Mar 31, 2024	PANAGORA ASSET MANAGEMENT INC	0.05%	23.19K	54.5K	-28.55K	-55.18%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.04%	18.3K	43.01K	18.3K	+100.00%
Mar 31, 2024	WELLS FARGO & COMPANY/MN	0.04%	18.9K	44.42K	9.52K	+101.52%
Mar 31, 2024	SG AMERICAS SECURITIES, LLC	0.04%	18.48K	43K	2.48K	+15.53%
Mar 31, 2024	DYNAMIC TECHNOLOGY LAB PRIVATE LTD	0.04%	17.53K	41K	17.53K	+100.00%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.04%	16.1K	37.84K	16.1K	+100.00%
Mar 31, 2024	PRINCIPAL FINANCIAL GROUP INC	0.03%	14.66K	34.46K	2.9K	+24.64%
Mar 31, 2024	NEW YORK STATE COMMON RETIREMENT FUND	0.03%	12.85K	30K	1.21K	+10.36%
Mar 31, 2024	INVESCO LTD.	0.03%	12.43K	29.22K	1.99K	+19.03%
Mar 31, 2024	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.03%	11.83K	65.32K	11.83K	+100.00%
Mar 31, 2024	CITIGROUP INC	0.03%	10.84K	25.48K	5.37K	+97.97%
Mar 31, 2024	QUANTBOT TECHNOLOGIES LP	0.01%	5.5K	12.93K	0	0
Mar 31, 2024	LAZARD ASSET MANAGEMENT LLC	0.01%	5.41K	12K	2.71K	+100.19%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.01%	4.74K	11.14M	2K	+72.97%
Mar 31, 2024	GAMMA INVESTING LLC	0.01%	3.83K	9K	0	0
Mar 31, 2024	AMERITAS INVESTMENT PARTNERS, INC.	0.01%	2.15K	5.04M	0	0
Mar 31, 2024	NORTHWEST FINANCIAL ADVISORS	0%	1.69K	3.96K	0	0
Mar 31, 2024	ADVISOR GROUP HOLDINGS, INC.	0%	1.65K	3.88K	0	0
Mar 31, 2024	AMALGAMATED BANK	0%	991	2K	-1.77K	-64.13%
Mar 31, 2024	MORGAN STANLEY	9.45%	4.07M	9.56M	1.27M	+45.32%
Mar 31, 2024	D. E. SHAW & CO., INC.	0.76%	325.95K	765.98K	-20.67K	-5.96%
Mar 31, 2024	ATOM INVESTORS LP	0.6%	259.31K	609.37K	259.31K	+100.00%
Mar 31, 2024	CITADEL ADVISORS LLC	0.55%	238.21K	559.8K	104.99K	+78.80%
Mar 31, 2024	XTX TOPCO LTD	0.53%	226.05K	531.22K	203.05K	+882.78%
Mar 31, 2024	FMR LLC	0.45%	194.2K	456.37K	58.29K	+42.89%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	0.44%	189.33K	444.92K	35.91K	+23.41%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.35%	150.08K	352.68K	80.62K	+116.06%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.34%	146.05K	343.22K	48.51K	+49.74%
Mar 31, 2024	PRUDENTIAL FINANCIAL INC	0.25%	107.2K	251.92K	47.55K	+79.72%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.24%	102K	239.7K	54.26K	+113.64%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.14%	61.89K	145.44K	61.89K	+100.00%
Mar 31, 2024	RHUMBLINE ADVISERS	0.14%	60.5K	142.16K	13.38K	+28.40%
Mar 31, 2024	JPMORGAN CHASE & CO	0.14%	59.24K	139.22K	39.41K	+198.75%
Mar 31, 2024	JANE STREET GROUP, LLC	0.14%	58.59K	137.69K	35.58K	+154.61%
Mar 31, 2024	UBS GROUP AG	0.12%	53.54K	125.81K	30.96K	+137.12%
Mar 31, 2024	BALYASNY ASSET MANAGEMENT L.P.	14.36%	6.18M	14.53M	6.18M	+100.00%
Mar 31, 2024	BLACKROCK INC.	7.84%	3.37M	7.93M	1.19M	+54.55%
Mar 31, 2024	WOODLINE PARTNERS LP	1.71%	735.1K	1.73M	735.1K	+100.00%
Mar 31, 2024	ALYESKA INVESTMENT GROUP, L.P.	1.52%	655.67K	1.54M	655.67K	+100.00%
Mar 31, 2024	DAFNA CAPITAL MANAGEMENT LLC	1.39%	600K	1.41M	600K	+100.00%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	1.21%	521.57K	1.23M	160.85K	+44.59%
Mar 31, 2024	TWO SIGMA ADVISERS, LP	1.18%	506.04K	1.19M	-14K	-2.69%
Mar 31, 2024	NORTHERN TRUST CORP	1.01%	435.62K	1.02M	203.53K	+87.70%
Mar 31, 2024	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.97%	416.29K	978.29K	416.29K	+100.00%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.95%	410.64K	964.99K	216.83K	+111.88%
Mar 31, 2024	JOHNSON & JOHNSON	0.85%	364.47K	856.51K	-324.12K	-47.07%
Mar 31, 2024	ACADIAN ASSET MANAGEMENT LLC	0.83%	355.34K	834K	-204.41K	-36.52%
Mar 31, 2024	SILVERARC CAPITAL MANAGEMENT, LLC	0.77%	331.28K	778.51K	331.28K	+100.00%
Mar 31, 2024	STONEPINE CAPITAL MANAGEMENT, LLC	0.33%	141.55K	332.64K	141.55K	+100.00%
Mar 31, 2024	EXCHANGE TRADED CONCEPTS, LLC	0.32%	138.99K	326.63K	57.01K	+69.53%
Mar 31, 2024	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.3%	129.8K	305.03K	75K	+136.86%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.25%	109.24K	256.72K	109.24K	+100.00%
Mar 31, 2024	CUBIST SYSTEMATIC STRATEGIES, LLC	0.11%	45.95K	107.99K	26.42K	+135.24%
Mar 31, 2024	ORBIMED ADVISORS LLC	26.59%	11.45M	26.9M	3.13M	+37.55%
Mar 31, 2024	RA CAPITAL MANAGEMENT, L.P.	17.52%	7.54M	17.72M	7.54M	+100.00%
Mar 31, 2024	TANG CAPITAL MANAGEMENT LLC	14.89%	6.41M	15.06M	5.53M	+631.14%
Mar 31, 2024	RTW INVESTMENTS, LP	9.61%	4.13M	9.72M	0	0
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	9.54%	4.11M	9.65M	2.78M	+210.70%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	9.31%	4.01M	9.41M	3.98M	+13,899.19%
Mar 31, 2024	VANGUARD GROUP INC	7.26%	3.13M	7.35M	1.44M	+85.55%
Mar 31, 2024	COMMODORE CAPITAL LP	3.19%	1.37M	3.23M	1.37M	+100.00%
Mar 31, 2024	BLACKSTONE INC.	2.87%	1.24M	2.91M	1.24M	+100.00%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	2.8%	1.2M	2.83M	543.17K	+82.07%
Mar 31, 2024	SCHONFELD STRATEGIC ADVISORS LLC	2.64%	1.13M	2.67M	934.3K	+466.92%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	2.44%	1.05M	2.47M	282.4K	+36.84%
Mar 31, 2024	STATE STREET CORP	2.18%	940.23K	2.21M	299.69K	+46.79%
Mar 31, 2024	COWEN AND COMPANY, LLC	2%	860.14K	2.02M	-1.86M	-68.32%
Mar 31, 2024	OCTAGON CAPITAL ADVISORS LP	1.78%	767.8K	1.8M	767.8K	+100.00%
Dec 31, 2023	EXCHANGE TRADED CONCEPTS, LLC	0.19%	81.99K	154.95K	20.79K	+33.97%
Dec 31, 2023	SG AMERICAS SECURITIES, LLC	0.04%	16K	30K	2.78K	+21.03%
Dec 31, 2023	SIMPLEX TRADING, LLC	0.04%	16.54K	31K	1.59K	+10.67%
Dec 31, 2023	SUMMIT TRAIL ADVISORS, LLC	0.04%	18K	34.02K	0	0
Dec 31, 2023	CUBIST SYSTEMATIC STRATEGIES, LLC	0.05%	19.54K	36.92K	-12.21K	-38.46%
Dec 31, 2023	JPMORGAN CHASE & CO	0.05%	19.83K	37.48K	-8.15K	-29.12%
Dec 31, 2023	GSA CAPITAL PARTNERS LLP	0.05%	20.67K	39K	-121.49K	-85.46%
Dec 31, 2023	UBS GROUP AG	0.05%	22.58K	42.67K	18.24K	+420.59%
Dec 31, 2023	XTX TOPCO LTD	0.05%	23K	43.47K	-32.61K	-58.64%
Dec 31, 2023	JANE STREET GROUP, LLC	0.05%	23.01K	43.49K	23.01K	+100.00%
Dec 31, 2023	SQUAREPOINT OPS LLC	0.07%	28.24K	53.37K	1.83K	+6.91%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.07%	28.61K	54.08K	-30.9K	-51.92%
Dec 31, 2023	SEI INVESTMENTS CO	0.07%	31.01K	58.61K	31.01K	+100.00%
Dec 31, 2023	ALLIANCEBERNSTEIN L.P.	0.09%	36.74K	69.44K	-3.8K	-9.37%
Dec 31, 2023	CORNERCAP INVESTMENT COUNSEL INC	0.09%	38.21K	72.22K	0	0
Dec 31, 2023	BARCLAYS PLC	0.1%	41.8K	79K	36.33K	+664.67%
Dec 31, 2023	DEUTSCHE BANK AG\	0.11%	45.71K	86.38K	40.09K	+713.56%
Dec 31, 2023	RHUMBLINE ADVISERS	0.11%	47.12K	89.04K	657	+1.41%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.11%	47.74K	90.24K	2.31K	+5.08%
Dec 31, 2023	PANAGORA ASSET MANAGEMENT INC	0.12%	51.75K	97.8K	51.75K	+100.00%
Dec 31, 2023	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.13%	54.8K	103.57K	-194.4K	-78.01%
Dec 31, 2023	PRUDENTIAL FINANCIAL INC	0.14%	59.65K	112.74K	0	0
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.16%	69.46K	131.28K	0	0
Dec 31, 2023	OCCUDO QUANTITATIVE STRATEGIES LP	0.18%	76.28K	144.17K	-4.85K	-5.98%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.23%	97.54K	184.35K	-33.85K	-25.77%
Dec 31, 2023	CITADEL ADVISORS LLC	0.04%	17.4K	32.89K	-3.3K	-15.94%
Dec 31, 2023	FMR LLC	0.32%	135.91K	256.88K	-84	-0.06%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	0.36%	153.41K	289.64K	-7.49K	-4.66%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.45%	193.8K	366.29K	31.01K	+19.05%
Dec 31, 2023	SCHONFELD STRATEGIC ADVISORS LLC	0.47%	200.1K	378.19K	200.1K	+100.00%
Dec 31, 2023	NORTHERN TRUST CORP	0.54%	232.09K	438.64K	1.68K	+0.73%
Dec 31, 2023	D. E. SHAW & CO., INC.	0.81%	346.62K	655.11K	101.75K	+41.55%
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	0.84%	360.73K	681.77K	135.41K	+60.10%
Dec 31, 2023	NORGES BANK	1%	429.55K	811.85K	429.55K	+100.00%
Dec 31, 2023	TWO SIGMA ADVISERS, LP	1.21%	520.04K	982.87K	133.34K	+34.48%
Dec 31, 2023	ACADIAN ASSET MANAGEMENT LLC	1.3%	559.75K	1.06M	36.74K	+7.02%
Dec 31, 2023	STATE STREET CORP	1.49%	640.54K	1.21M	7.01K	+1.11%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.54%	661.8K	1.25M	28.84K	+4.56%
Dec 31, 2023	JOHNSON & JOHNSON	1.6%	688.6K	1.3M	-40.35K	-5.54%
Dec 31, 2023	RENAISSANCE TECHNOLOGIES LLC	1.78%	766.6K	1.45M	89.6K	+13.23%
Dec 31, 2023	TANG CAPITAL MANAGEMENT LLC	2.04%	876.35K	1.66M	-350K	-28.54%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	3.07%	1.32M	2.5M	427.71K	+47.85%
Dec 31, 2023	VANGUARD GROUP INC	3.92%	1.69M	3.18M	12.69K	+0.76%
Dec 31, 2023	CARLYLE GROUP INC.	4.92%	2.12M	3.98M	0	0
Dec 31, 2023	BLACKROCK INC.	5.08%	2.18M	4.13M	-86.8K	-3.82%
Dec 31, 2023	COWEN AND COMPANY, LLC	6.32%	2.72M	5.13M	0	0
Dec 31, 2023	MORGAN STANLEY	6.51%	2.8M	5.29M	-1.04M	-27.05%
Dec 31, 2023	RTW INVESTMENTS, LP	9.62%	4.13M	7.81M	-106.84K	-2.52%
Dec 31, 2023	ORBIMED ADVISORS LLC	19.36%	8.32M	15.73M	0	0
Sep 30, 2023	RTW INVESTMENTS, LP	9.87%	4.24M	-	0	0
Sep 30, 2023	ROYAL BANK OF CANADA	0.01%	5.1K	-	1.93K	+60.64%
Sep 30, 2023	BARCLAYS PLC	0.01%	5.47K	-	-224.69K	-97.63%
Sep 30, 2023	GROUP ONE TRADING, L.P.	0.01%	5.49K	-	5.49K	+100.00%
Sep 30, 2023	DEUTSCHE BANK AG\	0.01%	5.62K	-	-1.02M	-99.45%
Sep 30, 2023	QUANTBOT TECHNOLOGIES LP	0.01%	6.1K	-	-6K	-49.59%
Sep 30, 2023	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0.02%	6.71K	-	-3.4K	-33.67%
Sep 30, 2023	WELLS FARGO & COMPANY/MN	0.02%	7.53K	-	-4.06K	-35.01%
Sep 30, 2023	TOWER RESEARCH CAPITAL LLC (TRC)	0.03%	10.91K	-	-406	-3.59%
Sep 30, 2023	POINT72 MIDDLE EAST FZE	0.03%	11.39K	-	11.39K	+100.00%
Sep 30, 2023	NEW YORK STATE COMMON RETIREMENT FUND	0.03%	11.73K	-	119	+1.02%
Sep 30, 2023	BALYASNY ASSET MANAGEMENT L.P.	0.03%	12.55K	-	12.55K	+100.00%
Sep 30, 2023	PRINCIPAL FINANCIAL GROUP INC	0.03%	12.7K	-	0	0
Sep 30, 2023	SG AMERICAS SECURITIES, LLC	0.03%	13.22K	-	13.22K	+100.00%
Sep 30, 2023	SIMPLEX TRADING, LLC	0.03%	14.95K	-	14.21K	+1,930.71%
Sep 30, 2023	AMERICAN INTERNATIONAL GROUP, INC.	0.04%	15.17K	-	539	+3.68%
Sep 30, 2023	SUMMIT TRAIL ADVISORS, LLC	0.04%	18K	-	8K	+80.00%
Sep 30, 2023	AMERICAN CENTURY COMPANIES INC	0.05%	21.79K	-	4.85K	+28.61%
Sep 30, 2023	MARQUETTE ASSET MANAGEMENT, LLC	0.07%	28.14K	-	28.14K	+100.00%
Sep 30, 2023	CUBIST SYSTEMATIC STRATEGIES, LLC	0.07%	31.75K	-	31.75K	+100.00%
Sep 30, 2023	CORNERCAP INVESTMENT COUNSEL INC	0.09%	38.21K	-	-481	-1.24%
Sep 30, 2023	ALLIANCEBERNSTEIN L.P.	0.09%	40.54K	-	0	0
Sep 30, 2023	RHUMBLINE ADVISERS	0.11%	46.46K	-	-563	-1.20%
Sep 30, 2023	XTX TOPCO LTD	0.13%	55.61K	-	13.46K	+31.92%
Sep 30, 2023	GOLDMAN SACHS GROUP INC	0.14%	59.51K	-	-10.48K	-14.97%
Sep 30, 2023	ORBIMED ADVISORS LLC	19.37%	8.32M	-	0	0
Sep 30, 2023	PRUDENTIAL FINANCIAL INC	0.14%	59.65K	-	0	0
Sep 30, 2023	EXCHANGE TRADED CONCEPTS, LLC	0.14%	61.2K	-	31.71K	+107.51%
Sep 30, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.16%	69.46K	-	-13.24K	-16.01%
Sep 30, 2023	OCCUDO QUANTITATIVE STRATEGIES LP	0.19%	81.13K	-	-62.41K	-43.48%
Sep 30, 2023	BANK OF NEW YORK MELLON CORP	0.31%	131.39K	-	30.53K	+30.27%
Sep 30, 2023	FMR LLC	0.32%	136K	-	64.93K	+91.37%
Sep 30, 2023	ACUITAS INVESTMENTS, LLC	0.32%	136.78K	-	136.78K	+100.00%
Sep 30, 2023	GSA CAPITAL PARTNERS LLP	0.33%	142.17K	-	37.19K	+35.43%
Sep 30, 2023	DIMENSIONAL FUND ADVISORS LP	0.37%	160.91K	-	-168K	-51.08%
Sep 30, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.38%	162.79K	-	-964	-0.59%
Sep 30, 2023	DECHENG CAPITAL MANAGEMENT III (CAYMAN), LLC	0.47%	200.2K	-	-305.47K	-60.41%
Sep 30, 2023	TWO SIGMA INVESTMENTS, LP	0.52%	225.32K	-	70.68K	+45.71%
Sep 30, 2023	NORTHERN TRUST CORP	0.54%	230.4K	-	-11.6K	-4.79%
Sep 30, 2023	D. E. SHAW & CO., INC.	0.57%	244.87K	-	213.42K	+678.51%
Sep 30, 2023	JACOBS LEVY EQUITY MANAGEMENT, INC	0.78%	333.59K	-	9.44K	+2.91%
Sep 30, 2023	TWO SIGMA ADVISERS, LP	0.9%	386.7K	-	281.9K	+269.00%
Sep 30, 2023	ACADIAN ASSET MANAGEMENT LLC	1.22%	523.01K	-	500.1K	+2,182.49%
Sep 30, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.47%	632.95K	-	-15	0.00%
Sep 30, 2023	JOHNSON & JOHNSON	1.7%	728.94K	-	0	0
Sep 30, 2023	DAFNA CAPITAL MANAGEMENT LLC	1.86%	797.05K	-	0	0
Sep 30, 2023	CARLYLE GROUP INC.	4.92%	2.12M	-	0	0
Sep 30, 2023	BLACKROCK INC.	5.28%	2.27M	-	-118.23K	-4.95%
Sep 30, 2023	COWEN AND COMPANY, LLC	6.32%	2.72M	-	-119.59K	-4.22%
Sep 30, 2023	MORGAN STANLEY	8.93%	3.84M	-	1.39M	+56.72%

Insiders

Insiders	Designation	Shares Held
SILVERSTEIN JONATHAN		4.83M
ORBIMED ADVISORS LLC	10 percent owner	4.49M
SINCLAIR ANDREW	director	2.14M
PURETECH HEALTH LLC	10 percent owner	2.12M
GORDON CARL L		990.25K
JAKOBOVITS AYA		356.35K
HEALEY DON	Chief Technology Officer	66.57K
GALIMI FRANCESCO	SVP & Chief Medical Officer	59.92K
SCHOR CHEN	President & CEO	43.47K
AFTAB BLAKE	Chief Scientific Officer	28.21K
DUBIN STEVE	director	10.9K
GIORDANO NATASHA	director	8.06K
KAUFFMAN MICHAEL	director	5.9K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Oct 08, 2025	ORBIMED ADVISORS LLC	PURCHASE	1.00	3.5M	3.5M	4.49M
Jun 05, 2024	KAUFFMAN MICHAEL	SALE	1.43	5.9K	8.44K	5.9K
Jan 25, 2024	GORDON CARL L	PURCHASE	2.40	242.2K	581.28K	990.25K
Jan 25, 2024	ORBIMED ADVISORS LLC	PURCHASE	2.40	242.2K	581.28K	990.25K
Oct 02, 2023	SCHOR CHEN	PURCHASE	1.33	5.5K	7.34K	43.47K
Sep 29, 2023	SCHOR CHEN	SALE	1.36	5.5K	7.48K	176.97K
Sep 28, 2023	SCHOR CHEN	SALE	1.42	5.5K	7.81K	37.97K
Jun 30, 2023	DUBIN STEVE	PURCHASE	2.40	5K	12K	10.9K
Jun 27, 2023	ORBIMED ADVISORS LLC	PURCHASE	2.09	250K	522.5K	646.66K
Jun 27, 2023	GORDON CARL L	PURCHASE	2.09	250K	522.5K	646.66K
Feb 15, 2023	HEALEY DON	SALE	7.57	4.53K	34.33K	66.57K
Feb 10, 2023	HEALEY DON	SALE	7.98	10.47K	83.48K	71.1K
Nov 10, 2022	SCHOR CHEN	SALE	20.06	30K	601.92K	53.42K
Nov 10, 2022	AFTAB BLAKE	SALE	21.00	6.97K	146.31K	28.21K
Nov 07, 2022	SCHOR CHEN	SALE	19.05	30K	571.49K	83.42K
Nov 03, 2022	SCHOR CHEN	SALE	18.04	24.81K	447.72K	113.42K
Nov 02, 2022	SCHOR CHEN	SALE	18.00	500	9K	138.24K
Oct 19, 2022	AFTAB BLAKE	SALE	16.27	8.07K	131.25K	35.18K
Oct 12, 2022	AFTAB BLAKE	SALE	15.40	1.65K	25.35K	51.18K
Sep 14, 2022	SCHOR CHEN	SALE	18.00	952	17.14K	138.74K
Sep 13, 2022	SCHOR CHEN	SALE	18.01	3.37K	60.71K	139.69K
Sep 12, 2022	SCHOR CHEN	SALE	16.77	66.75K	1.12M	0
Sep 09, 2022	SCHOR CHEN	SALE	16.51	8.09K	133.6K	66.75K
Aug 03, 2022	AFTAB BLAKE	SALE	18.00	6.97K	125.42K	38.97K
Aug 01, 2022	AFTAB BLAKE	SALE	16.64	6.97K	115.95K	45.94K
Jul 05, 2022	AFTAB BLAKE	SALE	14.50	1.36K	19.76K	52.9K
Apr 01, 2022	GALIMI FRANCESCO	SALE	21.00	1.78K	37.28K	59.92K
Mar 09, 2022	JAKOBOVITS AYA	SALE	14.00	2K	28K	356.35K
Feb 16, 2022	JAKOBOVITS AYA	SALE	14.83	2K	29.66K	358.34K
Feb 09, 2022	JAKOBOVITS AYA	SALE	14.03	4K	56.12K	360.34K
Jan 05, 2022	JAKOBOVITS AYA	SALE	16.93	2K	33.86K	364.34K
Jan 03, 2022	JAKOBOVITS AYA	SALE	18.02	6K	108.12K	366.34K
Dec 08, 2021	SINCLAIR ANDREW	PURCHASE	14.00	500K	7M	2.14M
Jun 16, 2021	SCHOR CHEN	SALE	10.53	7.48K	78.83K	74.84K
Jun 15, 2021	JAKOBOVITS AYA	SALE	11.16	1.92K	21.45K	215.88K
Jun 03, 2021	SCHOR CHEN	SALE	12.06	7.48K	90.22K	82.33K
May 20, 2021	JAKOBOVITS AYA	SALE	14.23	900	12.81K	217.81K
May 19, 2021	SCHOR CHEN	SALE	13.73	612	8.4K	89.81K
May 18, 2021	JAKOBOVITS AYA	SALE	14.05	3.11K	43.68K	218.7K
May 12, 2021	JAKOBOVITS AYA	SALE	13.24	5K	66.2K	221.81K
May 05, 2021	SCHOR CHEN	SALE	14.70	3.06K	44.95K	97.29K
Apr 20, 2021	SCHOR CHEN	SALE	12.01	7.48K	89.85K	104.78K
Apr 06, 2021	SCHOR CHEN	SALE	13.04	7.48K	97.58K	112.26K
Mar 30, 2021	SCHOR CHEN	SALE	13.22	4.5K	59.49K	119.75K
Mar 16, 2021	SCHOR CHEN	SALE	15.66	2.09K	32.71K	127.23K
Dec 18, 2019	PURETECH HEALTH LLC	SALE	1.20	6.16M	7.39M	2.12M
Dec 13, 2019	PURETECH HEALTH LLC	SALE	1.24	205.76K	255.8K	8.28M
Dec 12, 2019	PURETECH HEALTH LLC	SALE	1.25	385.88K	482.32K	8.49M
Dec 11, 2019	PURETECH HEALTH LLC	SALE	1.25	59.92K	74.9K	8.87M
Dec 10, 2019	PURETECH HEALTH LLC	SALE	1.26	336.56K	423.66K	8.93M
Nov 15, 2019	PURETECH HEALTH LLC	SALE	1.25	531.04K	661.94K	9.27M
Apr 16, 2018	SCHOR CHEN	PURCHASE	8.95	2K	17.91K	1.89M
Apr 11, 2018	SCHOR CHEN	PURCHASE	9.36	2K	18.72K	1.89M
Apr 10, 2018	SCHOR CHEN	PURCHASE	8.46	2K	16.91K	1.89M
Jan 30, 2018	ORBIMED ADVISORS LLC	PURCHASE	15.00	533.33K	8M	4.83M
Jan 30, 2018	SILVERSTEIN JONATHAN	PURCHASE	15.00	533.33K	8M	4.83M
Jan 30, 2018	PURETECH HEALTH LLC	PURCHASE	15.00	233.33K	3.5M	9.8M
Mar 04, 2015	GIORDANO NATASHA	SALE	20.92	2.16K	45.28K	8.06K
Sep 09, 2014	GIORDANO NATASHA	SALE	21.94	1.45K	31.88K	8.05K
Jun 06, 2014	GIORDANO NATASHA	SALE	17.28	1.16K	20.04K	9.51K
Jun 02, 2014	GIORDANO NATASHA	SALE	17.43	1.15K	20.03K	10.67K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE3.5M1

SALES00

NET SHARES3.5M1

SHARES HELD4.49M1

% NET SHARES-22.05%0%

ACET Stock Ownership Breakdown

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