How many institutions own ACAD stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own ACAD shares is 448, representing 101.95% of the company's common stock.

Who are the major shareholders selling ACADIA Pharmaceuticals Inc. stock?

JACOBS LEVY EQUITY MANAGEMENT, INC, in the last quarter, reduced its stake in ACAD by -2.51% restricting it's holding to 742.08 thousand shares of worth nearly $15.84M. ROCKEFELLER CAPITAL MANAGEMENT L.P. also lessened -11% of the ACAD shares from its portfolio, reducing its holding to 1.04 million shares of worth $22.11M. CITIGROUP INC also shunned ACAD shares holding by -5.57% last quarter which brought its holding to 1.57 million shares worth $33.59M.

Investors who are buying ACAD stock?

As per its latest 13F filing, TWO SIGMA INVESTMENTS, LP increased its stake in ACAD by 37.84% in the last quarter. The institutional holder raised its holding to 665.89 thousand shares having worth more than $14.21M. ADAGE CAPITAL PARTNERS GP, L.L.C. also added 311.42% more shares of ACAD to its portfolio, raising its holding to 2.48 million shares of worth $53.01M. FRAZIER LIFE SCIENCES MANAGEMENT, L.P. also increased its ACAD shares holding by 100% which brought its holding to 613.84 thousand shares worth $13.10M.

ACAD's major insiders: who are they?

The insider with the most stakes in ACAD is BAKER BROS. ADVISORS LP , at the company. Additionally, ACAD stock is highly held by CEO DAVIS STEPHEN and EVP, COO, HEAD OF COMMERCIAL Teehan Brendan among others.

Did an insider recently sell ACAD stock?

Company executives, directors, and other insiders own 0.54% percent of ACADIA Pharmaceuticals Inc.'s stock. Within the last six months, there have been 6 transaction(s) in which ACAD insiders have sold stock, totaling 71.44K shares. Insiders that have sold shares include KIHARA JAMES, SCHNEYER MARK C., and DALY JAMES M.

Which insider recently purchased ACAD stock?

There have been 0 transaction(s) during the past 6-months in which ACADIA Pharmaceuticals Inc. insiders have bought stock, totalling 0 shares

How much of ACAD does insiders own?

Around 191.4K ACADIA Pharmaceuticals Inc. shares are held by insiders, which represents about 0.54% of ACAD stock.

Who is the insider with the largest stake?

ACAD , BAKER BROS. ADVISORS LP holds the largest portfolio of the company's shares. ACAD shares owned by BAKER total nearly 3.58 million.

Which institution holds the most shares in ACAD?

JACOBS LEVY EQUITY MANAGEMENT, INC is the largest institutional owner in ACAD which holds 742.08 thousand shares worth $15.84M or 0.44% of the total ACAD shares outstanding followed by TWO SIGMA INVESTMENTS, LP with ownership of 665.89 thousand shares representing 0.4% of the ACAD ownership. ADAGE CAPITAL PARTNERS GP, L.L.C. is the third largest stakeholder with 2.48 million shares or 1.48% of the ownership worth more than $53.01M.

Is ACADIA Pharmaceuticals Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the ACAD is concerned, it is a stock which is optionable.

Is there a short position on ACAD's shares?

Number of ACAD shares short is 8.41M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding ACAD shares are there?

As of today, 169.18M shares of ACAD are outstanding.

Is there many float in ACAD stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, ACAD has 125.35M shares in float.

ACAD short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for ACAD is 5.9.

ACADIA Pharmaceuticals (ACAD) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares4.97

Short Percent Of Float7.79

Shares Outstanding169.18M

Shares Float125.35M

Shares Short8.41M

Short Ratio5.9

7.79%

Short % of Float

4.97%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

0.54% Percentage of Shares held by All Insiders

101.95% Percentage of Shares held by All Institutions

102.5% Percentage of Float held by Institutions

448

Number of Institutions Holding Shares

Institutional Ownership

About 101.95% of ACAD shares are held by financial institutions. JACOBS LEVY EQUITY MANAGEMENT, INC is the top corporate investor, holding 742.08K shares valued at $15.84M. A 0.44% stake in ACADIA Pharmaceuticals Inc. is owned by the company. TWO SIGMA INVESTMENTS, LP owns 665.89K shares valued at $14.21M, which translates its holding of 0.4% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	0.44%	742.08K	15.84M	-19.11K	-2.51%
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.4%	665.89K	14.21M	182.79K	+37.84%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.48%	2.48M	53.01M	1.88M	+311.42%
Sep 30, 2025	ROCKEFELLER CAPITAL MANAGEMENT L.P.	0.62%	1.04M	22.11M	-128.08K	-11.00%
Sep 30, 2025	CITIGROUP INC	0.94%	1.57M	33.59M	-92.77K	-5.57%
Sep 30, 2025	RTW INVESTMENTS, LP	4.26%	7.14M	152.46M	-1.85M	-20.58%
Sep 30, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.32%	534.11K	11.4M	-253.41K	-32.18%
Sep 30, 2025	BAKER BROS. ADVISORS LP	25.56%	42.9M	915.42M	0	0
Sep 30, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	0.37%	613.84K	13.1M	613.84K	+100.00%
Sep 30, 2025	RICE HALL JAMES & ASSOCIATES, LLC	0.37%	614.94K	13.12M	-54.87K	-8.19%
Sep 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.37%	620.83K	13.25M	329.13K	+112.83%
Sep 30, 2025	FIRST TRUST ADVISORS LP	1.16%	1.94M	41.47M	-491.22K	-20.18%
Sep 30, 2025	FMR LLC	0.4%	665.81K	14.21M	496.45K	+293.13%
Sep 30, 2025	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.66%	1.11M	23.7M	1.05M	+1,792.59%
Sep 30, 2025	MORGAN STANLEY	0.71%	1.19M	25.36M	-2.92M	-71.09%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.72%	1.2M	25.7M	14.23K	+1.20%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.88%	1.48M	31.65M	1.41M	+2,052.11%
Sep 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.89%	1.49M	31.72M	-1.69M	-53.15%
Sep 30, 2025	STATE STREET CORP	4.32%	7.26M	154.83M	1.08M	+17.44%
Sep 30, 2025	BLACKROCK, INC.	12.08%	20.27M	432.53M	-383.77K	-1.86%
Sep 30, 2025	UBS GROUP AG	0.4%	664.85K	14.19M	-71.38K	-9.70%
Sep 30, 2025	INVESCO LTD.	0.44%	740.58K	15.8M	-117.41K	-13.68%
Sep 30, 2025	CAPTION MANAGEMENT, LLC	0.38%	633.8K	13.53M	603.8K	+2,012.67%
Sep 30, 2025	FISHER ASSET MANAGEMENT, LLC	0.38%	638.49K	13.63M	328.18K	+105.76%
Sep 30, 2025	PANAGORA ASSET MANAGEMENT INC	0.39%	656.83K	14.02M	2.64K	+0.40%
Sep 30, 2025	AMERIPRISE FINANCIAL INC	0.41%	684.88K	14.62M	48.43K	+7.61%
Sep 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.41%	685.47K	14.63M	26.64K	+4.04%
Sep 30, 2025	ROYAL BANK OF CANADA	0.54%	900.43K	19.22M	841.87K	+1,437.69%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.86%	1.45M	30.93M	-98.2K	-6.34%
Sep 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	0.34%	575.54K	12.28M	-152.9K	-20.99%
Sep 30, 2025	PRINCIPAL FINANCIAL GROUP INC	0.42%	696.6K	14.87M	-13.56K	-1.91%
Sep 30, 2025	NUVEEN, LLC	0.57%	953.99K	20.36M	111.74K	+13.27%
Sep 30, 2025	TANG CAPITAL MANAGEMENT LLC	0.89%	1.5M	32.01M	0	0
Sep 30, 2025	DEUTSCHE BANK AG\	0.91%	1.52M	32.48M	787.58K	+107.21%
Sep 30, 2025	FRED ALGER MANAGEMENT, LLC	0.93%	1.57M	33.44M	-820.42K	-34.36%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	1.67%	2.8M	59.71M	402.53K	+16.80%
Sep 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.87%	1.46M	31.21M	-121.49K	-7.67%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.25%	2.1M	44.87M	633.96K	+43.17%
Sep 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.36%	596.44K	12.73M	-187.4K	-23.91%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.47%	795.87K	16.98M	-10.51K	-1.30%
Sep 30, 2025	VANGUARD GROUP INC	9.04%	15.18M	323.93M	-84.87K	-0.56%
Sep 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.08%	131.73K	2.81M	-8.39K	-5.99%
Sep 30, 2025	ERSTE ASSET MANAGEMENT GMBH	0.08%	133.7K	2.85M	-46.6K	-25.85%
Sep 30, 2025	ENVESTNET ASSET MANAGEMENT INC	0.09%	149.65K	3.19M	-13K	-7.99%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.09%	150.8K	3.22M	12.11K	+8.73%
Sep 30, 2025	BRIDGEWATER ASSOCIATES, LP	0.1%	163.25K	3.48M	163.25K	+100.00%
Sep 30, 2025	BIRCHVIEW CAPITAL, LP	0.1%	171K	3.65M	-16.8K	-8.95%
Sep 30, 2025	STONEPINE CAPITAL MANAGEMENT, LLC	0.1%	174.54K	3.72M	-50.46K	-22.42%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.12%	195.03K	4.16M	69.29K	+55.11%
Sep 30, 2025	AXECAP INVESTMENTS, LLC	0.12%	203.37K	4.34M	203.37K	+100.00%
Sep 30, 2025	SWISS NATIONAL BANK	0.14%	227.1K	4.85M	20.1K	+9.71%
Sep 30, 2025	EDGESTREAM PARTNERS, L.P.	0.14%	233.85K	4.99M	122.7K	+110.40%
Sep 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.14%	241.07K	5.14M	106.93K	+79.71%
Sep 30, 2025	NORDEA INVESTMENT MANAGEMENT AB	0.17%	280.31K	5.91M	2.61K	+0.94%
Sep 30, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.19%	315.32K	6.73M	-3.98K	-1.25%
Sep 30, 2025	JPMORGAN CHASE & CO	0.19%	325.92K	6.96M	13.98K	+4.48%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.2%	334.76K	7.14M	3.28K	+0.99%
Sep 30, 2025	FRANKLIN RESOURCES INC	0.23%	378.48K	7.01M	223.24K	+143.80%
Sep 30, 2025	RHUMBLINE ADVISERS	0.23%	391.55K	8.36M	24.46K	+6.66%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.25%	418.3K	8.93M	-1.15M	-73.31%
Sep 30, 2025	BARCLAYS PLC	0.26%	434.99K	9.28M	7.51K	+1.76%
Sep 30, 2025	GREAT LAKES ADVISORS, LLC	0.27%	454.79K	9.71M	-333.25K	-42.29%
Sep 30, 2025	JUPITER ASSET MANAGEMENT LTD	0.28%	476.32K	10.16M	-160.06K	-25.15%
Sep 30, 2025	PUBLIC SECTOR PENSION INVESTMENT BOARD	0.29%	486.99K	10.39M	64.74K	+15.33%
Sep 30, 2025	ALLSPRING GLOBAL INVESTMENTS HOLDINGS, LLC	0.31%	525.42K	11.16M	94.46K	+21.92%
Sep 30, 2025	CANDRIAM S.C.A.	0.32%	537.6K	11.47M	537.6K	+100.00%
Sep 30, 2025	EMERALD ADVISERS, LLC	0.34%	569.67K	12.16M	-22.69K	-3.83%
Sep 30, 2025	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	0.98%	1.65M	35.19M	1.31M	+390.09%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.53%	887.85K	18.95M	9.56K	+1.09%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.66%	1.1M	23.49M	172.13K	+18.53%
Sep 30, 2025	D. E. SHAW & CO., INC.	0.93%	1.56M	33.32M	-403.36K	-20.53%
Sep 30, 2025	PRUDENTIAL FINANCIAL INC	0.54%	909.42K	19.41M	223.94K	+32.67%
Sep 30, 2025	BRAIDWELL LP	1.42%	2.38M	50.76M	2.38M	+100.00%
Sep 30, 2025	PALO ALTO INVESTORS LP	1.47%	2.47M	52.64M	-96.53K	-3.77%
Sep 30, 2025	MARSHALL WACE, LLP	1.41%	2.36M	50.34M	389.17K	+19.76%
Sep 30, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.4%	668.36K	14.26M	25.92K	+4.03%
Sep 30, 2025	NORTHERN TRUST CORP	0.78%	1.3M	27.82M	920	+0.07%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.87%	3.13M	66.86M	108.55K	+3.59%
Jun 30, 2025	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	0.2%	336.44K	7.26M	336.44K	+100.00%
Jun 30, 2025	PUBLIC SECTOR PENSION INVESTMENT BOARD	0.25%	422.25K	9.11M	31.82K	+8.15%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.8%	3.02M	65.24M	69.58K	+2.36%
Jun 30, 2025	ALLSPRING GLOBAL INVESTMENTS HOLDINGS, LLC	0.26%	430.96K	9.21M	120.63K	+38.87%
Jun 30, 2025	TREXQUANT INVESTMENT LP	0.3%	509.95K	11M	215.65K	+73.28%
Jun 30, 2025	RICE HALL JAMES & ASSOCIATES, LLC	0.4%	669.81K	14.45M	-2.42K	-0.36%
Jun 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	0.43%	728.44K	15.71M	-124.41K	-14.59%
Jun 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.47%	783.85K	16.91M	134.64K	+20.74%
Jun 30, 2025	VANGUARD GROUP INC	9.1%	15.26M	329.25M	61.01K	+0.40%
Jun 30, 2025	UBS GROUP AG	0.44%	736.22K	15.88M	-320.63K	-30.34%
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	0.93%	1.57M	33.81M	-65.36K	-4.00%
Jun 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.94%	1.58M	34.4M	1.15M	+264.30%
Jun 30, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.38%	642.45K	13.86M	70.19K	+12.26%
Jun 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.07%	125.74K	2.71M	-74.55K	-37.22%
Jun 30, 2025	POINT72 EUROPE (LONDON) LLP	0.08%	134.96K	2.91M	-154.8K	-53.42%
Jun 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.08%	140.12K	3.02M	9.06K	+6.91%
Jun 30, 2025	PRIVIUM FUND MANAGEMENT B.V.	0.09%	148.4K	3.17M	0	0
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.09%	155.05K	3.34B	9.77K	+6.72%
Jun 30, 2025	TFG ASSET MANAGEMENT GP LTD	0.1%	161.4K	3.48M	54.4K	+50.84%
Jun 30, 2025	J. GOLDMAN & CO LP	0.1%	164.28K	3.54M	164.28K	+100.00%
Jun 30, 2025	FMR LLC	0.1%	169.36K	3.65B	-4.89K	-2.81%
Jun 30, 2025	SPHERA FUNDS MANAGEMENT LTD.	0.1%	174.9K	3.77M	174.9K	+100.00%
Jun 30, 2025	CANADA PENSION PLAN INVESTMENT BOARD	0.13%	209.9K	4.53M	-79.6K	-27.50%
Jun 30, 2025	STONEPINE CAPITAL MANAGEMENT, LLC	0.13%	225K	4.85M	131.61K	+140.92%
Jun 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.17%	291.7K	6.29B	224.03K	+331.05%
Jun 30, 2025	ASSENAGON ASSET MANAGEMENT S.A.	1.02%	1.71M	36.92M	-1.95M	-53.28%
Jun 30, 2025	MARSHALL WACE, LLP	1.17%	1.97M	42.49M	1.64M	+496.17%
Jun 30, 2025	FRED ALGER MANAGEMENT, LLC	1.42%	2.39M	51.5M	-382.37K	-13.80%
Jun 30, 2025	D. E. SHAW & CO., INC.	1.17%	1.96M	42.37M	-384.9K	-16.38%
Jun 30, 2025	MORGAN STANLEY	2.45%	4.11M	88.68M	-568.94K	-12.16%
Jun 30, 2025	EMERALD ADVISERS, LLC	0.35%	592.36K	12.78M	-223.55K	-27.40%
Jun 30, 2025	PALO ALTO INVESTORS LP	1.53%	2.56M	55.29M	-100.72K	-3.78%
Jun 30, 2025	CITADEL ADVISORS LLC	1.8%	3.01M	64.98M	2.72M	+922.43%
Jun 30, 2025	STATE STREET CORP	3.68%	6.18M	133.26M	-815.47K	-11.66%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.52%	878.28K	18.94M	158.05K	+21.94%
Jun 30, 2025	EDGESTREAM PARTNERS, L.P.	0.07%	111.14K	2.4M	-47.96K	-30.15%
Jun 30, 2025	ALPS ADVISORS INC	0.07%	111.9K	2.41M	-28.33K	-20.20%
Jun 30, 2025	GREAT LAKES ADVISORS, LLC	0.47%	788.04K	17M	175.36K	+28.62%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.36%	603.8K	13.02M	603.8K	+100.00%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	1.43%	2.4M	51.68M	740.23K	+44.72%
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	1.89%	3.17M	68.43M	-1.48M	-31.74%
Jun 30, 2025	RTW INVESTMENTS, LP	5.36%	9M	194.03M	455.43K	+5.33%
Jun 30, 2025	FIRST TRUST ADVISORS LP	1.45%	2.43M	52.51M	65.91K	+2.78%
Jun 30, 2025	AMERIPRISE FINANCIAL INC	0.38%	636.45K	13.73M	-60.37K	-8.66%
Jun 30, 2025	PANAGORA ASSET MANAGEMENT INC	0.39%	654.19K	14.11M	435	+0.07%
Jun 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.39%	658.84K	14.21M	597.25K	+969.80%
Jun 30, 2025	PRUDENTIAL FINANCIAL INC	0.41%	685.48K	14.79M	330.88K	+93.31%
Jun 30, 2025	PRINCIPAL FINANCIAL GROUP INC	0.42%	710.16K	15.32M	-44.59K	-5.91%
Jun 30, 2025	DEUTSCHE BANK AG\	0.44%	734.62K	15.85M	-25.97K	-3.41%
Jun 30, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	0.45%	761.18K	16.42M	-1.22M	-61.51%
Jun 30, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.47%	787.52K	16.99M	-16.6K	-2.06%
Jun 30, 2025	WOODLINE PARTNERS LP	0.5%	837.2K	18.06M	541.99K	+183.59%
Jun 30, 2025		0.5%	842.26K	18.17M	-459.97K	-35.32%
Jun 30, 2025	INVESCO LTD.	0.51%	857.98K	18.51M	126.4K	+17.28%
Jun 30, 2025	ROCKEFELLER CAPITAL MANAGEMENT L.P.	0.69%	1.16M	25.12M	26.3K	+2.31%
Jun 30, 2025	NORGES BANK	0.88%	1.47M	31.68M	1.47M	+100.00%
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.92%	1.55M	33.38M	70.7K	+4.79%
Jun 30, 2025	CITIGROUP INC	0.99%	1.67M	35.95M	-185.54K	-10.02%
Jun 30, 2025	BLACKROCK, INC.	12.31%	20.65M	445.47M	-714.14K	-3.34%
Jun 30, 2025	BAKER BROS. ADVISORS LP	25.56%	42.9M	925.28M	18.77K	+0.04%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.48%	806.38K	17.39M	1.99K	+0.25%
Jun 30, 2025	NUVEEN, LLC	0.5%	842.26K	18.17M	-459.97K	-35.32%
Jun 30, 2025	JUPITER ASSET MANAGEMENT LTD	0.38%	636.38K	13.73M	229.32K	+56.34%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.55%	928.75K	20.03M	279.37K	+43.02%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.71%	1.19M	25.67M	-10.98K	-0.91%
Jun 30, 2025	BURNEY CO/	0.07%	113.75K	2.45M	-284.34K	-71.43%
Jun 30, 2025	NORTHERN TRUST CORP	0.78%	1.3M	28.1M	-72.6K	-5.28%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.88%	1.47M	31.68M	-710.28K	-32.60%
Jun 30, 2025	TANG CAPITAL MANAGEMENT LLC	0.89%	1.5M	32.36M	0	0
Jun 30, 2025	HOHIMER WEALTH MANAGEMENT, LLC	0.07%	117.88K	2.54M	-42.76K	-26.62%
Jun 30, 2025	STATE OF WISCONSIN INVESTMENT BOARD	0.11%	186.36K	4.02M	-6.24K	-3.24%
Jun 30, 2025	BIRCHVIEW CAPITAL, LP	0.11%	187.8K	4.05M	-75.6K	-28.70%
Jun 30, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.11%	190K	4.1M	-120.95K	-38.90%
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.12%	199.02K	4.29M	199.02K	+100.00%
Jun 30, 2025	LSV ASSET MANAGEMENT	0.13%	210K	4.53M	133.76K	+175.44%
Jun 30, 2025	NORDEA INVESTMENT MANAGEMENT AB	0.17%	277.7K	6.11M	2.63K	+0.96%
Jun 30, 2025	MAN GROUP PLC	0.17%	286.93K	6.19M	90.62K	+46.16%
Jun 30, 2025	FISHER ASSET MANAGEMENT, LLC	0.18%	310.31K	6.69M	-44.71K	-12.59%
Jun 30, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.19%	319.31K	6.89M	-175.78K	-35.50%
Mar 31, 2025	AMERICAN CENTURY COMPANIES INC	0.98%	1.63M	27.12M	1.49M	+1,055.81%
Mar 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	2.79%	4.65M	77.2M	2.42M	+108.35%
Mar 31, 2025	ASSENAGON ASSET MANAGEMENT S.A.	2.2%	3.66M	60.84M	3.66M	+100.00%
Mar 31, 2025	ROCKEFELLER CAPITAL MANAGEMENT L.P.	0.68%	1.14M	18.9M	-25.36K	-2.18%
Mar 31, 2025	UBS GROUP AG	0.63%	1.06M	17.55M	-184.43K	-14.86%
Mar 31, 2025	EVENTIDE ASSET MANAGEMENT, LLC	0.51%	852.85K	14.17M	0	0
Mar 31, 2025	VANGUARD GROUP INC	9.11%	15.2M	252.53M	1.26M	+9.00%
Mar 31, 2025	RTW INVESTMENTS, LP	5.12%	8.54M	141.85M	-165.38K	-1.90%
Mar 31, 2025	BAKER BROS. ADVISORS LP	25.71%	42.88M	712.2M	0	0
Mar 31, 2025	FRED ALGER MANAGEMENT, LLC	1.66%	2.77M	46.01M	54.9K	+2.02%
Mar 31, 2025	PALO ALTO INVESTORS LP	1.6%	2.66M	44.25M	-84.67K	-3.08%
Mar 31, 2025	FIRST TRUST ADVISORS LP	1.42%	2.37M	39.34M	-331.66K	-12.28%
Mar 31, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	1.19%	1.98M	32.85M	838.73K	+73.66%
Mar 31, 2025	CITIGROUP INC	1.11%	1.85M	30.77M	184.62K	+11.07%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.99%	1.66M	27.5M	568.53K	+52.31%
Mar 31, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.47%	786.8K	13.07M	786.8K	+100.00%
Mar 31, 2025	DEUTSCHE BANK AG\	0.46%	760.59K	12.63M	-281.85K	-27.04%
Mar 31, 2025	PRINCIPAL FINANCIAL GROUP INC	0.45%	754.75K	12.54M	611.05K	+425.25%
Mar 31, 2025	INVESCO LTD.	0.44%	731.58K	12.15M	219.26K	+42.80%
Mar 31, 2025	TANG CAPITAL MANAGEMENT LLC	0.9%	1.5M	24.92M	0	0
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.89%	1.48M	24.53M	250.5K	+20.42%
Mar 31, 2025	NORTHERN TRUST CORP	0.82%	1.38M	22.84M	142.85K	+11.59%
Mar 31, 2025		0.78%	1.3M	21.63M	1.3M	+100.00%
Mar 31, 2025	GREAT LAKES ADVISORS, LLC	0.37%	612.68K	10.18M	72.67K	+13.46%
Mar 31, 2025	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.34%	572.26K	9.51M	-113.46K	-16.55%
Mar 31, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0.31%	523.03K	8.69M	-111.49K	-17.57%
Mar 31, 2025	JANUS HENDERSON GROUP PLC	0.26%	425.9K	7.27M	373.08K	+706.27%
Mar 31, 2025	D. E. SHAW & CO., INC.	1.41%	2.35M	39.02M	-891.99K	-27.52%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	1.31%	2.18M	36.19M	-701.69K	-24.36%
Mar 31, 2025	AMERIPRISE FINANCIAL INC	0.42%	696.83K	11.57M	-188.05K	-21.25%
Mar 31, 2025	RICE HALL JAMES & ASSOCIATES, LLC	0.4%	672.22K	11.17M	-9.31K	-1.37%
Mar 31, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.48%	804.12K	13.36M	176.1K	+28.04%
Mar 31, 2025	PANAGORA ASSET MANAGEMENT INC	0.39%	653.76K	10.86M	-1.38K	-0.21%
Mar 31, 2025	BLACKROCK, INC.	12.81%	21.37M	354.9M	8.64M	+67.85%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.39%	649.38K	10.79M	28.37K	+4.57%
Mar 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.39%	649.21K	10.78M	17.79K	+2.82%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.26%	425.47K	7.07M	-498.02K	-53.93%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.77%	2.95M	49.09M	77.4K	+2.69%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.72%	1.2M	19.95M	-50.49K	-4.04%
Mar 31, 2025	TWO SIGMA ADVISERS, LP	0.58%	967.5K	16.07M	-295.7K	-23.41%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.49%	816.66K	13.56M	-426.79K	-34.32%
Mar 31, 2025	EMERALD ADVISERS, LLC	0.49%	815.91K	13.55M	-9.16K	-1.11%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.48%	804.39K	13.36M	394.64K	+96.31%
Mar 31, 2025	STATE STREET CORP	4.19%	6.99M	116.16M	2.47M	+54.68%
Mar 31, 2025	MORGAN STANLEY	2.81%	4.68M	77.74M	-2.62M	-35.86%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.43%	720.24K	11.96M	39.38K	+5.78%
Mar 31, 2025	SOFINNOVA INVESTMENTS, INC.	0.3%	500K	8.31M	500K	+100.00%
Mar 31, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.3%	495.08K	8.22M	-5.31K	-1.06%
Mar 31, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	0.28%	470.34K	7.81M	0	0
Mar 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.26%	434.96K	7.42M	-32.49K	-6.95%
Mar 31, 2024	VANGUARD GROUP INC	8.07%	13.3M	245.89M	-97.47K	-0.73%
Mar 31, 2024	TANG CAPITAL MANAGEMENT LLC	0.31%	518.9K	9.59M	404.5K	+353.58%
Mar 31, 2024	MARSHALL WACE, LLP	0.32%	522.41K	9.66M	522.41K	+100.00%
Mar 31, 2024	CITADEL ADVISORS LLC	0.35%	569.26K	10.53M	416.22K	+271.98%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.35%	573.8K	10.61M	389.8K	+211.85%
Mar 31, 2024	AVIDITY PARTNERS MANAGEMENT LP	0.36%	588.5K	10.88M	588.5K	+100.00%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.39%	644.07K	11.91M	363.81K	+129.81%
Mar 31, 2024	CUTTER CAPITAL MANAGEMENT, LP	0.4%	658.41K	12.17M	327.44K	+98.93%
Mar 31, 2024	CANADA PENSION PLAN INVESTMENT BOARD	0.4%	661.6K	12.23M	661.6K	+100.00%
Mar 31, 2024	RICE HALL JAMES & ASSOCIATES, LLC	0.4%	664.56K	12.29M	-28.3K	-4.08%
Mar 31, 2024	CAPITAL FUND MANAGEMENT S.A.	0.42%	695.55K	12.86M	451.74K	+185.28%
Mar 31, 2024	PANAGORA ASSET MANAGEMENT INC	0.43%	701.29K	12.97M	56.37K	+8.74%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.44%	727.91K	13.46M	-76.27K	-9.48%
Mar 31, 2024	EMERALD MUTUAL FUND ADVISERS TRUST	0.76%	1.25M	23.12M	-54.33K	-4.16%
Mar 31, 2024	PICTET ASSET MANAGEMENT HOLDING SA	0.79%	1.31M	23.99M	-153.47K	-10.50%
Mar 31, 2024	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.82%	1.36M	25.11M	75.8K	+5.91%
Mar 31, 2024	MORGAN STANLEY	0.89%	1.46M	27.05M	101.11K	+7.42%
Mar 31, 2024	JUPITER ASSET MANAGEMENT LTD	0.97%	1.6M	29.65M	281.41K	+21.28%
Mar 31, 2024	FIRST TRUST ADVISORS LP	1%	1.65M	30.49M	-128.51K	-7.23%
Mar 31, 2024	EMERALD ADVISERS, LLC	1%	1.65M	30.53M	5.56K	+0.34%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	1.28%	2.11M	38.93M	340.67K	+19.30%
Mar 31, 2024	FRED ALGER MANAGEMENT, LLC	1.37%	2.26M	41.74M	-919.21K	-28.94%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	1.69%	2.79M	51.65M	101.09K	+3.75%
Mar 31, 2024	FMR LLC	2.42%	3.99M	73.85M	-1.27M	-24.15%
Mar 31, 2024	MACQUARIE GROUP LTD	0.28%	467.46K	8.64M	379.81K	+433.33%
Mar 31, 2024	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	0.29%	470.34K	8.7M	-260.58K	-35.65%
Mar 31, 2024	JPMORGAN CHASE & CO	0.29%	475K	8.78M	-185.9K	-28.13%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.31%	503.05K	9.3M	-47.86K	-8.69%
Mar 31, 2024	FINEPOINT CAPITAL LP	0.51%	840.45K	15.54M	70.8K	+9.20%
Mar 31, 2024	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.52%	856.3K	15.83M	228.92K	+36.49%
Mar 31, 2024	SQUAREPOINT OPS LLC	0.61%	1.01M	18.66M	731.93K	+264.19%
Mar 31, 2024	PRUDENTIAL FINANCIAL INC	0.65%	1.07M	19.83M	629.62K	+142.09%
Mar 31, 2024	NORTHERN TRUST CORP	0.72%	1.19M	22.04M	-22.31K	-1.84%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.27%	437.88K	8.1M	20.81K	+4.99%
Mar 31, 2024	CUBIST SYSTEMATIC STRATEGIES, LLC	0.27%	451.52K	8.35M	66.27K	+17.20%
Mar 31, 2024	CAPTION MANAGEMENT, LLC	0.28%	462.2K	8.55M	437.2K	+1,748.80%
Mar 31, 2024	AMERIPRISE FINANCIAL INC	0.45%	742.18K	13.72M	95.07K	+14.69%
Mar 31, 2024	POINT72 ASSET MANAGEMENT, L.P.	0.47%	776.7K	14.36M	383.87K	+97.72%
Mar 31, 2024	ROCKEFELLER CAPITAL MANAGEMENT L.P.	0.48%	788.45K	14.58M	232.12K	+41.72%
Mar 31, 2024	DEUTSCHE BANK AG\	0.62%	1.03M	19.01M	2.81K	+0.27%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.71%	1.17M	21.66M	325.6K	+38.49%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.72%	1.19M	21.99M	61.14K	+5.42%
Mar 31, 2024	PALO ALTO INVESTORS LP	1.47%	2.41M	44.65M	5.39K	+0.22%
Mar 31, 2024	D. E. SHAW & CO., INC.	1.6%	2.64M	48.85M	-1.11M	-29.63%
Mar 31, 2024	PRICE T ROWE ASSOCIATES INC /MD/	2.43%	4M	73.95M	-1.18M	-22.77%
Mar 31, 2024	ECOR1 CAPITAL, LLC	3.64%	5.99M	110.78M	0	0
Mar 31, 2024	STATE STREET CORP	3.64%	6M	110.97M	-463.62K	-7.17%
Mar 31, 2024	BLACKROCK INC.	7.08%	11.67M	215.76M	258.26K	+2.26%
Mar 31, 2024	RTW INVESTMENTS, LP	8.39%	13.83M	255.7M	2.58M	+22.89%
Mar 31, 2024	BAKER BROS. ADVISORS LP	26.01%	42.86M	792.57M	0	0
Mar 31, 2024	JUMP FINANCIAL, LLC	0.09%	149K	2.76M	32.66K	+28.07%
Mar 31, 2024	SEVEN EIGHT CAPITAL, LP	0.09%	151.17K	2.8M	84.96K	+128.33%
Mar 31, 2024	FISHER ASSET MANAGEMENT, LLC	0.09%	152.93K	2.83M	9.88K	+6.90%
Mar 31, 2024	HILLSDALE INVESTMENT MANAGEMENT INC.	0.1%	157.69K	2.92B	12.53K	+8.63%
Mar 31, 2024	EMPIRE LIFE INVESTMENTS INC.	0.1%	169.84K	3.14M	-4.98K	-2.85%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.11%	173.1K	3.2M	173.1K	+100.00%
Mar 31, 2024	RHUMBLINE ADVISERS	0.11%	184.38K	3.41M	1.1K	+0.60%
Mar 31, 2024	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	0.11%	189.27K	3.5M	-281.73K	-59.81%
Mar 31, 2024	STATE OF WISCONSIN INVESTMENT BOARD	0.12%	193.95K	3.59M	65.53K	+51.02%
Mar 31, 2024	SWISS NATIONAL BANK	0.13%	210.6K	3.89M	800	+0.38%
Mar 31, 2024	NEW YORK STATE COMMON RETIREMENT FUND	0.13%	212.92K	3.94M	-716	-0.34%
Mar 31, 2024	ELEQUIN SECURITIES, LLC	0.15%	248.84K	4.62M	248.84K	+100.00%
Mar 31, 2024	BIRCHVIEW CAPITAL, LP	0.15%	250.4K	4.63M	10K	+4.16%
Mar 31, 2024	WCM INVESTMENT MANAGEMENT, LLC	0.17%	282.04K	5.21M	282.04K	+100.00%
Mar 31, 2024		0.19%	312.33K	5.62M	312.33K	+100.00%
Mar 31, 2024	NORDEA INVESTMENT MANAGEMENT AB	0.2%	322.5K	5.94M	-263.5K	-44.97%
Mar 31, 2024	TREXQUANT INVESTMENT LP	0.21%	339.51K	6.28M	297.37K	+705.60%
Mar 31, 2024	UBS GROUP AG	0.21%	343.88K	6.36M	36.52K	+11.88%
Mar 31, 2024	INVESCO LTD.	0.21%	350.39K	6.48M	-72.58K	-17.16%
Mar 31, 2024	CITIGROUP INC	0.21%	353.9K	6.54M	131.19K	+58.90%
Mar 31, 2024	ALGERT GLOBAL LLC	0.22%	354.34K	6.55M	93.47K	+35.83%
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	0.24%	391.23K	7.23M	-36.71K	-8.58%
Mar 31, 2024	CANDRIAM S.C.A.	0.25%	405.75K	7.5M	405.75K	+100.00%
Dec 31, 2023	NORGES BANK	0.88%	1.44M	45.19M	1.44M	+100.00%
Dec 31, 2023	CUBIST SYSTEMATIC STRATEGIES, LLC	0.23%	385.25K	12.06M	385.25K	+100.00%
Dec 31, 2023	POINT72 ASSET MANAGEMENT, L.P.	0.24%	392.83K	12.3M	342.18K	+675.68%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.25%	417.07K	13.06M	-34.23K	-7.58%
Dec 31, 2023	INVESCO LTD.	0.26%	422.97K	13.24M	90K	+27.03%
Dec 31, 2023	RAFFERTY ASSET MANAGEMENT, LLC	0.26%	427.93K	13.4M	91.32K	+27.13%
Dec 31, 2023	PRUDENTIAL FINANCIAL INC	0.27%	443.12K	13.87M	115.5K	+35.25%
Dec 31, 2023	JANE STREET GROUP, LLC	0.27%	446.32K	13.97M	128.35K	+40.37%
Dec 31, 2023	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	0.29%	471K	14.75M	234K	+98.73%
Dec 31, 2023	WOODLINE PARTNERS LP	0.29%	474.16K	14.85M	474.16K	+100.00%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.31%	507.69K	15.9M	-264.27K	-34.23%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.34%	550.91K	17.25M	-14.98K	-2.65%
Dec 31, 2023	ROCKEFELLER CAPITAL MANAGEMENT L.P.	0.34%	556.34K	17.42M	51.16K	+10.13%
Dec 31, 2023	ALYESKA INVESTMENT GROUP, L.P.	0.36%	585.04K	18.32M	185.04K	+46.26%
Dec 31, 2023	NORDEA INVESTMENT MANAGEMENT AB	0.36%	586K	18.55M	-12.4K	-2.07%
Dec 31, 2023	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.38%	627.38K	19.64M	-6.09K	-0.96%
Dec 31, 2023	FULLER & THALER ASSET MANAGEMENT, INC.	0.39%	641.19K	20.08M	641.19K	+100.00%
Dec 31, 2023	PANAGORA ASSET MANAGEMENT INC	0.39%	644.92K	20.19M	1.92K	+0.30%
Dec 31, 2023	AMERIPRISE FINANCIAL INC	0.39%	647.11K	20.26M	67.61K	+11.67%
Dec 31, 2023	JPMORGAN CHASE & CO	0.4%	660.9K	20.69M	202.99K	+44.33%
Dec 31, 2023	RICE HALL JAMES & ASSOCIATES, LLC	0.42%	692.85K	21.69M	-3.21K	-0.46%
Dec 31, 2023	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	0.45%	730.92K	22.89M	100.02K	+15.85%
Dec 31, 2023	FINEPOINT CAPITAL LP	0.47%	769.65K	24.1M	213.1K	+38.29%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.49%	804.17K	25.18M	85.55K	+11.90%
Dec 31, 2023	EVENTIDE ASSET MANAGEMENT, LLC	0.49%	809.39K	25.34M	809.39K	+100.00%
Dec 31, 2023	FRONTIER CAPITAL MANAGEMENT CO LLC	0.5%	823.59K	25.79M	65.97K	+8.71%
Dec 31, 2023	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.52%	846.03K	26.49M	-204.37K	-19.46%
Dec 31, 2023	DEUTSCHE BANK AG\	0.62%	1.03M	32.11M	958.54K	+1,433.19%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.69%	1.13M	35.31M	54.81K	+5.11%
Dec 31, 2023	NORTHERN TRUST CORP	0.74%	1.21M	38.01M	-6.54K	-0.54%
Dec 31, 2023	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.78%	1.28M	40.14M	237.68K	+22.76%
Dec 31, 2023	EMERALD MUTUAL FUND ADVISERS TRUST	0.79%	1.3M	40.85M	568	+0.04%
Dec 31, 2023	JUPITER ASSET MANAGEMENT LTD	0.81%	1.32M	41.4M	46.15K	+3.62%
Dec 31, 2023	MORGAN STANLEY	0.83%	1.36M	42.64M	-494.48K	-26.64%
Dec 31, 2023		0.89%	1.46M	45.75M	109.64K	+8.11%
Dec 31, 2023	EMERALD ADVISERS, LLC	1%	1.65M	51.52M	-35.49K	-2.11%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	1.07%	1.76M	55.25M	-648.79K	-26.88%
Dec 31, 2023	FIRST TRUST ADVISORS LP	1.08%	1.78M	55.65M	148.53K	+9.12%
Dec 31, 2023	PALO ALTO INVESTORS LP	1.47%	2.41M	75.44M	3.76K	+0.16%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.64%	2.69M	84.3M	113.77K	+4.41%
Dec 31, 2023	FRED ALGER MANAGEMENT, LLC	1.93%	3.18M	99.46M	67.89K	+2.18%
Dec 31, 2023	D. E. SHAW & CO., INC.	2.29%	3.75M	117.56M	-1.03M	-21.60%
Dec 31, 2023	PRICE T ROWE ASSOCIATES INC /MD/	3.15%	5.18M	162.14M	-51.65K	-0.99%
Dec 31, 2023	FMR LLC	3.21%	5.27M	164.86M	-36.62K	-0.69%
Dec 31, 2023	ECOR1 CAPITAL, LLC	3.65%	5.99M	187.59M	0	0
Dec 31, 2023	STATE STREET CORP	3.94%	6.47M	202.42M	1.25M	+24.00%
Dec 31, 2023	RTW INVESTMENTS, LP	6.85%	11.25M	352.35M	-322.99K	-2.79%
Dec 31, 2023	BLACKROCK INC.	6.95%	11.41M	357.26M	1.38M	+13.78%
Dec 31, 2023	VANGUARD GROUP INC	8.16%	13.4M	419.43M	-220.73K	-1.62%
Dec 31, 2023	BAKER BROS. ADVISORS LP	26.1%	42.86M	1.34B	0	0
Sep 30, 2023	GOLDMAN SACHS GROUP INC	0.44%	718.63K	-	-554.8K	-43.57%
Sep 30, 2023	RHUMBLINE ADVISERS	0.11%	184.4K	-	3.62K	+2.00%
Sep 30, 2023	SECTORAL ASSET MANAGEMENT INC	0.13%	209.96K	-	209.96K	+100.00%
Sep 30, 2023	QUBE RESEARCH & TECHNOLOGIES LTD	0.13%	212.92K	-	188.08K	+757.20%
Sep 30, 2023	BARCLAYS PLC	0.13%	217.27K	-	27.73K	+14.63%
Sep 30, 2023	RTW INVESTMENTS, LP	7.08%	11.58M	-	1.79M	+18.33%
Sep 30, 2023	BLACKROCK INC.	6.14%	10.03M	-	-10.92K	-0.11%
Sep 30, 2023	ECOR1 CAPITAL, LLC	3.67%	5.99M	-	0	0
Sep 30, 2023	FMR LLC	3.24%	5.3M	-	-19.26K	-0.36%
Sep 30, 2023	D. E. SHAW & CO., INC.	2.93%	4.79M	-	-474.08K	-9.01%
Sep 30, 2023	FRED ALGER MANAGEMENT, LLC	1.9%	3.11M	-	867.82K	+38.72%
Sep 30, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.58%	2.58M	-	84.04K	+3.37%
Sep 30, 2023	MORGAN STANLEY	1.14%	1.86M	-	-1.87M	-50.20%
Sep 30, 2023	EMERALD ADVISERS, LLC	1.03%	1.68M	-	64.1K	+3.96%
Sep 30, 2023	FIRST TRUST ADVISORS LP	1%	1.63M	-	-875.66K	-34.96%
Sep 30, 2023	JACOBS LEVY EQUITY MANAGEMENT, INC	0.87%	1.42M	-	-411.62K	-22.42%
Sep 30, 2023		0.83%	1.35M	-	1.35M	+100.00%
Sep 30, 2023	EMERALD MUTUAL FUND ADVISERS TRUST	0.8%	1.3M	-	12.89K	+1.00%
Sep 30, 2023	JUPITER ASSET MANAGEMENT LTD	0.78%	1.28M	-	4.93K	+0.39%
Sep 30, 2023	NORTHERN TRUST CORP	0.75%	1.22M	-	57.56K	+4.95%
Sep 30, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.66%	1.07M	-	91.64K	+9.34%
Sep 30, 2023	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.64%	1.05M	-	137.37K	+15.05%
Sep 30, 2023	TD ASSET MANAGEMENT INC	0.14%	225.7K	-	51.27K	+29.40%
Sep 30, 2023	SWISS NATIONAL BANK	0.14%	232.4K	-	-14.9K	-6.03%
Sep 30, 2023	NEW YORK STATE COMMON RETIREMENT FUND	0.14%	233.51K	-	71.14K	+43.81%
Sep 30, 2023	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	0.15%	237K	-	47K	+24.74%
Sep 30, 2023	BIRCHVIEW CAPITAL, LP	0.15%	240.4K	-	-9K	-3.61%
Sep 30, 2023	SOLEUS CAPITAL MANAGEMENT, L.P.	0.15%	244.63K	-	178.63K	+270.65%
Sep 30, 2023	VOYA INVESTMENT MANAGEMENT LLC	0.16%	255.71K	-	272	+0.11%
Sep 30, 2023	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.17%	276.83K	-	276.83K	+100.00%
Sep 30, 2023	PENN CAPITAL MANAGEMENT COMPANY, LLC	0.18%	289.28K	-	102.28K	+54.69%
Sep 30, 2023	BAKER BROS. ADVISORS LP	26.22%	42.86M	-	0	0
Sep 30, 2023	BNP PARIBAS ARBITRAGE, SNC	0.19%	305.17K	-	7.75K	+2.60%
Sep 30, 2023	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.64%	1.04M	-	529.93K	+102.98%
Sep 30, 2023	JANE STREET GROUP, LLC	0.19%	317.96K	-	204.88K	+181.18%
Sep 30, 2023	RUSSELL INVESTMENTS GROUP, LTD.	0.2%	320.84K	-	-15.94K	-4.73%
Sep 30, 2023	PRUDENTIAL FINANCIAL INC	0.2%	327.62K	-	168.19K	+105.50%
Sep 30, 2023	INVESCO LTD.	0.2%	332.97K	-	-64.55K	-16.24%
Sep 30, 2023	RAFFERTY ASSET MANAGEMENT, LLC	0.21%	336.61K	-	584	+0.17%
Sep 30, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.28%	451.3K	-	-239.66K	-34.69%
Sep 30, 2023	ROCKEFELLER CAPITAL MANAGEMENT L.P.	0.31%	505.17K	-	100.88K	+24.95%
Sep 30, 2023	FINEPOINT CAPITAL LP	0.34%	556.55K	-	-290.4K	-34.29%
Sep 30, 2023	BANK OF NEW YORK MELLON CORP	0.35%	565.89K	-	-1.98K	-0.35%
Sep 30, 2023	AMERIPRISE FINANCIAL INC	0.35%	579.51K	-	11.46K	+2.02%
Sep 30, 2023	NORDEA INVESTMENT MANAGEMENT AB	0.37%	598.4K	-	-175	-0.03%
Sep 30, 2023	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	0.39%	630.9K	-	-226.44K	-26.41%
Sep 30, 2023	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.39%	633.47K	-	97.89K	+18.28%
Sep 30, 2023	PANAGORA ASSET MANAGEMENT INC	0.39%	643K	-	-32.16K	-4.76%
Sep 30, 2023	RICE HALL JAMES & ASSOCIATES, LLC	0.43%	696.07K	-	-190.39K	-21.48%

Insiders

Among the ACAD insiders holding of 0.54% of the stake in company, BAKER BROS. ADVISORS LP, , holds the largest shares of 3.58M. DAVIS STEPHEN, CEO, is the second largest ACAD insider with ownership of 186.56K shares. TEEHAN BRENDAN, EVP, COO, HEAD OF COMMERCIAL, stands third with possession of 62.11K shares of that stake.

Insiders	Designation	Shares Held
BAKER BROS. ADVISORS LP		3.58M
DAVIS STEPHEN	CEO	186.56K
TEEHAN BRENDAN	EVP, COO, HEAD OF COMMERCIAL	62.11K
STANKOVIC SRDJAN R.	President	61.23K
SCHNEYER MARK C.	EVP, CHIEF FINANCIAL OFFICER	53.34K
KIM AUSTIN D.	EVP,General Counsel, Secretary	46.9K
GAROFALO ELIZABETH A.	director	25.38K
KIHARA JAMES	PRINCIPAL ACCOUNTING OFFICER	25.06K
BREGE LAURA	director	15.1K
RIDLOFF ELENA	EVP and CFO	10.55K
YANG MICHAEL J.	EVP and CCO	8.06K
DALY JAMES M	director	4.04K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Nov 18, 2025	KIHARA JAMES	SALE	23.69	4.08K	96.75K	25.06K
Nov 18, 2025	SCHNEYER MARK C.	SALE	23.69	10.26K	243.11K	53.34K
Nov 10, 2025	DALY JAMES M	SALE	22.37	30K	670.98K	4.04K
Sep 15, 2025	SCHNEYER MARK C.	SALE	23.65	3.5K	82.73K	43.45K
Sep 02, 2025	GAROFALO ELIZABETH A.	SALE	25.98	1.6K	41.56K	25.38K
Aug 18, 2025	SCHNEYER MARK C.	SALE	25.18	22K	554.02K	40.13K
Jun 04, 2025	BREGE LAURA	SALE	21.78	14.45K	314.63K	15.1K
May 16, 2025	SCHNEYER MARK C.	SALE	25.00	2K	50K	62.13K
May 16, 2025	KIHARA JAMES	SALE	20.00	2K	40K	20.4K
May 02, 2025	KIHARA JAMES	SALE	14.60	1.33K	19.37K	23.53K
May 02, 2025	SCHNEYER MARK C.	SALE	14.60	3.5K	51.07K	62.77K
Apr 08, 2025	KIHARA JAMES	SALE	14.82	1.03K	15.23K	22.26K
Apr 08, 2025	SCHNEYER MARK C.	SALE	14.82	2.71K	40.13K	59.46K
Mar 26, 2025	SCHNEYER MARK C.	SALE	17.05	3.17K	54.07K	56.89K
Mar 26, 2025	KIHARA JAMES	SALE	17.05	1.1K	18.67K	21.28K
Mar 05, 2025	GAROFALO ELIZABETH A.	SALE	18.23	4.92K	89.67K	17.6K
Feb 24, 2025	SCHNEYER MARK C.	SALE	19.96	773	15.43K	53.88K
Feb 24, 2025	KIHARA JAMES	SALE	19.96	475	9.48K	20.23K
Nov 19, 2024	KIHARA JAMES	SALE	16.81	4.07K	68.47K	19.86K
Nov 19, 2024	TEEHAN BRENDAN	SALE	16.81	10.33K	173.63K	62.11K
Nov 19, 2024	SCHNEYER MARK C.	SALE	16.81	10.26K	172.45K	53.3K
Aug 19, 2024	TEEHAN BRENDAN	SALE	15.28	9.53K	145.68K	52.18K
Aug 19, 2024	DAVIS STEPHEN	SALE	15.28	31.75K	485.09K	186.56K
Aug 19, 2024	SCHNEYER MARK C.	SALE	15.28	9.73K	148.72K	43.74K
Jun 10, 2024	SCHNEYER MARK C.	SALE	14.79	975	14.42K	34.56K
May 02, 2024	DAVIS STEPHEN	SALE	16.94	11.43K	193.57K	155.23K
May 02, 2024	TEEHAN BRENDAN	SALE	16.94	3.48K	58.9K	42.13K
May 02, 2024	SCHNEYER MARK C.	SALE	16.94	3.5K	59.34K	32.05K
May 02, 2024	KIHARA JAMES	SALE	16.94	1.33K	22.46K	14.37K
Apr 08, 2024	SCHNEYER MARK C.	SALE	17.87	2.72K	48.53K	28.74K
Apr 08, 2024	TEEHAN BRENDAN	SALE	17.87	2.57K	45.89K	38.8K
Apr 08, 2024	DAVIS STEPHEN	SALE	17.87	17.72K	316.58K	144.27K
Apr 08, 2024	KIHARA JAMES	SALE	17.87	762	13.62K	13.1K
Mar 27, 2024	DAVIS STEPHEN	SALE	17.90	17.71K	317.08K	118.84K
Mar 27, 2024	TEEHAN BRENDAN	SALE	17.90	5.14K	92.01K	36.34K
Mar 27, 2024	SCHNEYER MARK C.	SALE	17.90	5.43K	97.27K	26.18K
Feb 26, 2024	TEEHAN BRENDAN	SALE	24.67	624	15.39K	31.43K
Feb 26, 2024	DAVIS STEPHEN	SALE	24.67	5.58K	137.58K	101.89K
Feb 26, 2024	SCHNEYER MARK C.	SALE	24.67	772	19.05K	21.07K
Feb 26, 2024	KIHARA JAMES	SALE	24.67	474	11.69K	11.39K
Jan 08, 2024	KIM AUSTIN D.	SALE	29.96	590	17.68K	46.9K
Jan 08, 2024	DAVIS STEPHEN	SALE	29.96	3.73K	111.81K	96.52K
Jan 08, 2024	TEEHAN BRENDAN	SALE	29.96	731	21.9K	30.95K
Dec 15, 2023	KIHARA JAMES	SALE	28.30	2K	56.6K	11.03K
Nov 20, 2023	TEEHAN BRENDAN	SALE	22.64	4.96K	112.29K	30.39K
Nov 20, 2023	SCHNEYER MARK C.	SALE	22.64	5.11K	115.65K	20.49K
Nov 20, 2023	KIHARA JAMES	SALE	22.64	1.99K	44.94K	13.03K
Oct 06, 2023	KIM AUSTIN D.	SALE	21.96	16.37K	359.46K	45.86K
Oct 06, 2023	DAVIS STEPHEN	SALE	21.96	51.56K	1.13M	89.13K
Sep 15, 2023	KIHARA JAMES	SALE	25.88	2K	51.76K	10.78K
Aug 21, 2023	SCHNEYER MARK C.	SALE	29.00	10K	289.97K	15.68K
Jul 14, 2023	DAVIS STEPHEN	SALE	30.04	100K	3M	36.7K
Jul 12, 2023	DAVIS STEPHEN	SALE	25.05	55.1K	1.38M	36.7K
Jul 11, 2023	DAVIS STEPHEN	SALE	25.00	16.5K	412.45K	91.8K
Jun 15, 2023	KIHARA JAMES	SALE	24.15	2K	48.3K	9.14K
Jun 12, 2023	BREGE LAURA	SALE	24.87	4.5K	111.91K	13.5K
Jun 08, 2023	SCHNEYER MARK C.	SALE	25.02	974	24.37K	22.82K
May 24, 2023	BAKER BROS. ADVISORS LP	PURCHASE	25.27	20.3K	513.13K	3.58M
May 23, 2023	BAKER BROS. ADVISORS LP	PURCHASE	25.33	10.86K	275.04K	3.56M
May 22, 2023	BAKER BROS. ADVISORS LP	PURCHASE	24.46	7.65K	187K	3.53M
May 17, 2023	SCHNEYER MARK C.	SALE	22.50	15.31K	344.48K	21.91K
May 17, 2023	KIHARA JAMES	SALE	22.50	5.95K	133.81K	11.14K
May 17, 2023	TEEHAN BRENDAN	SALE	22.50	14.87K	334.55K	24.36K
May 01, 2023	DAVIS STEPHEN	SALE	21.18	7.81K	165.33K	108.3K
May 01, 2023	KIM AUSTIN D.	SALE	21.18	917	19.42K	25.51K
May 01, 2023	TEEHAN BRENDAN	SALE	21.18	548	11.61K	9.49K
Apr 10, 2023	KIHARA JAMES	SALE	18.14	523	9.49K	5.2K
Apr 06, 2023	DAVIS STEPHEN	SALE	18.16	8.58K	155.85K	100.48K
Apr 06, 2023	KIM AUSTIN D.	SALE	18.16	1.46K	26.44K	23.43K
Apr 06, 2023	KIHARA JAMES	SALE	18.16	701	12.73K	4.23K
Apr 06, 2023	TEEHAN BRENDAN	SALE	18.16	1.75K	31.8K	8.47K
Apr 06, 2023	SCHNEYER MARK C.	SALE	18.16	1.92K	34.79K	7.48K
Feb 24, 2023	DAVIS STEPHEN	SALE	18.78	3.85K	72.32K	91.73K
Feb 24, 2023	TEEHAN BRENDAN	SALE	18.78	461	8.66K	5.2K
Feb 24, 2023	KIHARA JAMES	SALE	18.78	350	6.57K	2.92K
Feb 24, 2023	SCHNEYER MARK C.	SALE	18.78	577	10.84K	4.12K
Feb 24, 2023	KIM AUSTIN D.	SALE	18.78	803	15.08K	20.11K
Jan 12, 2023	BREGE LAURA	SALE	18.25	12.5K	228.13K	0
Jan 09, 2023	TEEHAN BRENDAN	SALE	17.13	532	9.11K	4.55K
Jan 09, 2023	KIM AUSTIN D.	SALE	17.13	589	10.09K	18.7K
Jan 09, 2023	DAVIS STEPHEN	SALE	17.13	3.9K	66.88K	84.63K
Nov 21, 2022	STANKOVIC SRDJAN R.	SALE	15.07	1.85K	27.83K	61.23K
Oct 15, 2022	DAVIS STEPHEN	SALE	15.81	2.8K	44.33K	79.01K
Oct 15, 2022	STANKOVIC SRDJAN R.	SALE	15.81	1.33K	20.96K	56.83K
Jun 08, 2022	SCHNEYER MARK C.	SALE	17.91	653	11.69K	3.34K
Apr 29, 2022	STANKOVIC SRDJAN R.	SALE	18.18	2.87K	52.09K	55.19K
Apr 29, 2022	KIM AUSTIN D.	SALE	18.18	894	16.25K	16.74K
Apr 29, 2022	DAVIS STEPHEN	SALE	18.18	5.48K	99.69K	75.88K
Apr 29, 2022	TEEHAN BRENDAN	SALE	18.18	552	10.04K	3.44K
Apr 07, 2022	KIHARA JAMES	SALE	27.05	1.03K	27.73K	2.43K
Feb 23, 2022	DAVIS STEPHEN	SALE	23.80	3.93K	93.49K	65.73K
Feb 23, 2022	STANKOVIC SRDJAN R.	SALE	23.80	1.5K	35.72K	48.44K
Feb 23, 2022	KIM AUSTIN D.	SALE	23.80	782	18.61K	14.63K
Feb 23, 2022	SCHNEYER MARK C.	SALE	23.80	553	13.16K	2.1K
Feb 23, 2022	TEEHAN BRENDAN	SALE	23.80	472	11.23K	2.42K
Feb 23, 2022	KIHARA JAMES	SALE	23.80	359	8.54K	481
Jan 06, 2022	DAVIS STEPHEN	SALE	23.05	3.72K	85.7K	58.72K
Jan 06, 2022	KIM AUSTIN D.	SALE	23.05	574	13.23K	13.2K
Jan 06, 2022	TEEHAN BRENDAN	SALE	23.05	538	12.4K	1.79K
Jan 06, 2022	STANKOVIC SRDJAN R.	SALE	23.05	1.94K	44.65K	45.02K
Nov 22, 2021	STANKOVIC SRDJAN R.	SALE	19.01	2.8K	53.29K	41.51K
Oct 18, 2021	DAVIS STEPHEN	SALE	17.41	2.96K	51.59K	52.91K
Oct 18, 2021	STANKOVIC SRDJAN R.	SALE	17.41	1.34K	23.29K	38.07K
Apr 30, 2021	KIM AUSTIN D.	SALE	20.33	1.05K	21.43K	11.37K
Apr 30, 2021	DAVIS STEPHEN	SALE	20.33	7.85K	159.59K	49.31K
Apr 30, 2021	STANKOVIC SRDJAN R.	SALE	20.33	4.23K	86K	36.43K
Apr 30, 2021	RIDLOFF ELENA	SALE	20.33	1.03K	20.98K	10.55K
Feb 04, 2021	STANKOVIC SRDJAN R.	SALE	50.61	8.43K	426.59K	31.05K
Feb 04, 2021	RIDLOFF ELENA	SALE	50.61	2.05K	103.8K	8.34K
Feb 04, 2021	KIM AUSTIN D.	SALE	50.61	2.11K	106.64K	9.91K
Feb 04, 2021	DAVIS STEPHEN	SALE	50.61	14.2K	718.41K	28.9K
Jan 12, 2021	STANKOVIC SRDJAN R.	SALE	55.01	700	38.51K	20.25K
Jan 08, 2021	STANKOVIC SRDJAN R.	SALE	55.22	29.73K	1.64M	20.25K
Jan 07, 2021	STANKOVIC SRDJAN R.	SALE	55.12	61.62K	3.4M	20.25K
Jan 06, 2021	YANG MICHAEL J.	SALE	53.34	1.12K	59.74K	8.06K
Jan 06, 2021	DAVIS STEPHEN	SALE	53.34	3.48K	185.84K	24.48K
Jan 06, 2021	STANKOVIC SRDJAN R.	SALE	53.34	1.73K	92.01K	20.25K
Jan 06, 2021	RIDLOFF ELENA	SALE	53.34	1.02K	54.19K	3.9K
Jan 06, 2021	KIM AUSTIN D.	SALE	53.34	678	36.16K	5.52K
Nov 20, 2020	STANKOVIC SRDJAN R.	SALE	53.50	2.73K	145.95K	16.53K
Oct 27, 2020	KIM AUSTIN D.	SALE	45.10	8.75K	394.64K	3.85K
Oct 16, 2020	STANKOVIC SRDJAN R.	SALE	42.56	1.3K	55.2K	13.01K
Oct 16, 2020	YANG MICHAEL J.	SALE	42.56	1.25K	53.07K	6.46K
Oct 16, 2020	DAVIS STEPHEN	SALE	42.56	2.96K	125.98K	14.79K
Jul 07, 2020	YANG MICHAEL J.	SALE	56.05	16.15K	905.21K	16.3K
Jun 19, 2020	STANKOVIC SRDJAN R.	SALE	50.12	16.45K	824.52K	11.33K
Jun 18, 2020	STANKOVIC SRDJAN R.	SALE	50.01	65.84K	3.29M	11.33K
May 14, 2020	DAVIS STEPHEN	SALE	45.65	84.22K	3.84M	16.13K
May 13, 2020	DAVIS STEPHEN	SALE	48.98	13.91K	681.24K	109.36K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES71.44K6

NET SHARES-71.44K6

SHARES HELD191.4K6

% NET SHARES-137.33%0%

Frequently Asked Questions