How many institutions own WVE stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own WVE shares is 267, representing 78.86% of the company's common stock.

Who are the major shareholders selling Wave Life Sciences Ltd. stock?

WELLS FARGO & COMPANY/MN, in the last quarter, reduced its stake in WVE by -40.79% restricting it's holding to 73.81 thousand shares of worth nearly $540.30K. CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD. also lessened -16.57% of the WVE shares from its portfolio, reducing its holding to 77.9 thousand shares of worth $570.19K. LOOMIS SAYLES & CO L P also shunned WVE shares holding by -11.84% last quarter which brought its holding to 2.91 million shares worth $21.27M.

Investors who are buying WVE stock?

As per its latest 13F filing, STEMPOINT CAPITAL LP increased its stake in WVE by 134.37% in the last quarter. The institutional holder raised its holding to 2.11 million shares having worth more than $15.45M. GOLDMAN SACHS GROUP INC also added 111.02% more shares of WVE to its portfolio, raising its holding to 2.13 million shares of worth $15.56M. STATE STREET CORP also increased its WVE shares holding by 3.25% which brought its holding to 2.85 million shares worth $20.84M.

WVE's major insiders: who are they?

The insider with the most stakes in WVE is GSK plc , 10 percent owner at the company. Additionally, WVE stock is highly held by RA CAPITAL MANAGEMENT, L.P. and RA CAPITAL MANAGEMENT, LLC among others.

Did an insider recently sell WVE stock?

Company executives, directors, and other insiders own 13.73% percent of Wave Life Sciences Ltd.'s stock. Within the last six months, there have been 17 transaction(s) in which WVE insiders have sold stock, totaling 491.84K shares. Insiders that have sold shares include FRANCIS CHRIS, MORAN KYLE, and HENRY CHRISTIAN O.

Which insider recently purchased WVE stock?

There have been 2 transaction(s) during the past 6-months in which Wave Life Sciences Ltd. insiders have bought stock, totalling 1471000 shares

How much of WVE does insiders own?

Around 43.3M Wave Life Sciences Ltd. shares are held by insiders, which represents about 13.73% of WVE stock.

Who is the insider with the largest stake?

WVE 10 percent owner, GSK plc holds the largest portfolio of the company's shares. WVE shares owned by GSK total nearly 18.25 million.

Which institution holds the most shares in WVE?

WELLS FARGO & COMPANY/MN is the largest institutional owner in WVE which holds 73.81 thousand shares worth $540.30K or 0.05% of the total WVE shares outstanding followed by A16Z PERENNIAL MANAGEMENT, L.P. with ownership of 77.62 thousand shares representing 0.05% of the WVE ownership. CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD. is the third largest stakeholder with 77.9 thousand shares or 0.05% of the ownership worth more than $570.19K.

Is Wave Life Sciences Ltd. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the WVE is concerned, it is a stock which is optionable.

Is there a short position on WVE's shares?

Number of WVE shares short is 17.32M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding WVE shares are there?

As of today, 159.23M shares of WVE are outstanding.

Is there many float in WVE stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, WVE has 65.60M shares in float.

WVE short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for WVE is 10.51.

Wave Life Sciences (WVE) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares10.88

Short Percent Of Float14.71

Shares Outstanding159.23M

Shares Float65.60M

Shares Short17.32M

Short Ratio10.51

14.71%

Short % of Float

10.88%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

13.73% Percentage of Shares held by All Insiders

78.86% Percentage of Shares held by All Institutions

91.42% Percentage of Float held by Institutions

267

Number of Institutions Holding Shares

Institutional Ownership

About 78.86% of WVE shares are held by financial institutions. WELLS FARGO & COMPANY/MN is the top corporate investor, holding 73.81K shares valued at $540.30K. A 0.05% stake in Wave Life Sciences Ltd. is owned by the company. A16Z PERENNIAL MANAGEMENT, L.P. owns 77.62K shares valued at $568.17K, which translates its holding of 0.05% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.05%	73.81K	540.3K	-50.86K	-40.79%
Sep 30, 2025	A16Z PERENNIAL MANAGEMENT, L.P.	0.05%	77.62K	568.17K	0	0
Sep 30, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.05%	77.9K	570.19K	-15.48K	-16.57%
Sep 30, 2025	STEMPOINT CAPITAL LP	1.29%	2.11M	15.45M	1.21M	+134.37%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.3%	2.13M	15.56M	1.12M	+111.02%
Sep 30, 2025	STATE STREET CORP	1.74%	2.85M	20.84M	89.61K	+3.25%
Sep 30, 2025	LOOMIS SAYLES & CO L P	1.77%	2.91M	21.27M	-390.23K	-11.84%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.78%	2.92M	21.37M	158.99K	+5.76%
Sep 30, 2025	MACQUARIE GROUP LTD	0.05%	81.96K	600K	-184.9K	-69.29%
Sep 30, 2025	RHUMBLINE ADVISERS	0.1%	159.17K	1.17M	-3.43K	-2.11%
Sep 30, 2025	PRIVIUM FUND MANAGEMENT B.V.	0.1%	170K	1.24M	34.45K	+25.42%
Sep 30, 2025	JANE STREET GROUP, LLC	0.3%	497K	3.64M	497K	+100.00%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.41%	665.15K	4.87M	19.59K	+3.03%
Sep 30, 2025	UBS GROUP AG	0.43%	705.61K	5.17M	98.34K	+16.19%
Sep 30, 2025	WALLEYE CAPITAL LLC	0.45%	730.64K	5.35M	262.75K	+56.16%
Sep 30, 2025	JPMORGAN CHASE & CO	0.52%	860.14K	6.3M	-708.87K	-45.18%
Sep 30, 2025	RTW INVESTMENTS, LP	0.55%	900K	6.59M	0	0
Sep 30, 2025	PFIZER INC	1.14%	1.88M	13.73M	0	0
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.61%	998.37K	7.31M	-12.29K	-1.22%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.18%	297.86K	2.18M	8.57K	+2.96%
Sep 30, 2025	NEWTYN MANAGEMENT, LLC	0.18%	300K	2.2M	-100K	-25.00%
Sep 30, 2025	BAKER BROS. ADVISORS LP	0.21%	344.06K	2.52M	0	0
Sep 30, 2025	NORTHERN TRUST CORP	0.62%	1.01M	7.41M	2.97K	+0.29%
Sep 30, 2025	SWISS NATIONAL BANK	0.13%	211K	1.54M	5.8K	+2.83%
Sep 30, 2025	NUVEEN, LLC	0.15%	249.47K	1.83M	0	0
Sep 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.16%	258.01K	1.89M	227.17K	+736.50%
Sep 30, 2025	EMERALD ADVISERS, LLC	1.83%	3M	21.94M	-260.22K	-7.99%
Sep 30, 2025	VANGUARD GROUP INC	1.91%	3.14M	22.98M	-337.24K	-9.70%
Sep 30, 2025	ENSIGN PEAK ADVISORS, INC	0.19%	313.31K	2.29M	0	0
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.26%	429.62K	3.14M	131.73K	+44.22%
Sep 30, 2025	MORGAN STANLEY	0.31%	507.29K	3.71M	-1.04M	-67.15%
Sep 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.33%	540.44K	3.96M	506.44K	+1,489.52%
Sep 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.34%	555.54K	3.96M	-65.83K	-10.59%
Sep 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.4%	663.97K	4.86M	663.97K	+100.00%
Sep 30, 2025	POLAR CAPITAL HOLDINGS PLC	0.65%	1.06M	7.78M	58.78K	+5.86%
Sep 30, 2025	ARTISAN PARTNERS LIMITED PARTNERSHIP	0.75%	1.23M	9.03M	-1.03M	-45.56%
Sep 30, 2025	BIOIMPACT CAPITAL LLC	0.92%	1.51M	11.02M	0	0
Sep 30, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	1.08%	1.77M	12.93M	-171.43K	-8.85%
Sep 30, 2025	MOODY ALDRICH PARTNERS LLC	0.21%	350.55K	2.57M	-71.3K	-16.90%
Sep 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.22%	368.71K	2.7M	10.28K	+2.87%
Sep 30, 2025	MAVERICK CAPITAL LTD	0.23%	380K	2.78M	23.3K	+6.53%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.24%	390.75K	2.86M	-301.67K	-43.57%
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.34%	563K	4.12M	319.84K	+131.53%
Sep 30, 2025	PRIMECAP MANAGEMENT CO/CA/	1.16%	1.9M	13.9M	-567.2K	-23.00%
Sep 30, 2025	AFFINITY ASSET ADVISORS, LLC	1.28%	2.1M	15.37M	99.69K	+4.98%
Sep 30, 2025	PLATINUM INVESTMENT MANAGEMENT LTD	0.16%	267.79K	1.96M	-87.56K	-24.64%
Sep 30, 2025	BARCLAYS PLC	0.17%	272.87K	2M	-300.31K	-52.39%
Sep 30, 2025	SUSQUEHANNA PORTFOLIO STRATEGIES, LLC	0.19%	305.37K	2.24M	20.29K	+7.12%
Sep 30, 2025	F/M INVESTMENTS LLC	0.19%	318.09K	2.33M	74.41K	+30.54%
Sep 30, 2025	KNOTT DAVID M JR	0.05%	90K	658.8K	50K	+125.00%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	59.21K	433.39K	-8.05K	-11.97%
Sep 30, 2025	DEUTSCHE BANK AG\	0.06%	94.27K	690.02K	9.73K	+11.52%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.06%	101.92K	746.03K	-134	-0.13%
Sep 30, 2025	JAMES J. BURNS & COMPANY, LLC	0.06%	105.8K	774.47K	-16.11K	-13.22%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.07%	107.05K	783.58K	-43.47K	-28.88%
Sep 30, 2025	INVESCO LTD.	0.09%	141.13K	1.03M	26.17K	+22.76%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.09%	142.41K	1.04M	-37.2K	-20.71%
Sep 30, 2025	FRANKLIN RESOURCES INC	0.04%	62.26K	455.74K	277	+0.45%
Sep 30, 2025	DLD ASSET MANAGEMENT, LP	0.04%	70.9K	519.34K	70.9K	+100.00%
Sep 30, 2025	SEI INVESTMENTS CO	0.04%	72.26K	528.91K	-16.56K	-18.65%
Sep 30, 2025	SIREN, L.L.C.	2.25%	3.7M	27.06M	0	0
Sep 30, 2025	FEDERATED HERMES, INC.	2.29%	3.75M	27.46M	3.75M	+678,144.67%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.47%	4.04M	29.61M	-1.15M	-22.08%
Sep 30, 2025	BELLEVUE GROUP AG	2.5%	4.09M	29.97M	0	0
Sep 30, 2025	683 CAPITAL MANAGEMENT, LLC	2.53%	4.15M	30.38M	50K	+1.22%
Sep 30, 2025	KYNAM CAPITAL MANAGEMENT, LP	2.78%	4.56M	33.38M	0	0
Sep 30, 2025	FMR LLC	3.13%	5.13M	37.55M	4.51M	+728.63%
Sep 30, 2025	M28 CAPITAL MANAGEMENT LP	3.45%	5.66M	41.46M	0	0
Sep 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	3.84%	6.3M	46.1M	-233.46K	-3.57%
Sep 30, 2025	BLACKROCK, INC.	6.36%	10.43M	76.35M	47.1K	+0.45%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	8.88%	14.57M	106.64M	-448.72K	-2.99%
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	11.1%	18.2M	133.24M	0	0
Sep 30, 2025	GLENMEDE INVESTMENT MANAGEMENT, LP	0.03%	44.33K	324.47K	-8.7K	-16.40%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	45.89K	335.9K	-20.31K	-30.68%
Sep 30, 2025	HANDELSBANKEN FONDER AB	0.03%	50.8K	372K	0	0
Sep 30, 2025	GSA CAPITAL PARTNERS LLP	0.03%	51.2K	375K	51.2K	+100.00%
Jun 30, 2025	PRIMECAP MANAGEMENT CO/CA/	1.5%	2.47M	16.03M	-41.67K	-1.66%
Jun 30, 2025	EMERALD ADVISERS, LLC	1.99%	3.26M	21.17M	123.56K	+3.94%
Jun 30, 2025	LOOMIS SAYLES & CO L P	2.01%	3.3M	21.42M	859.16K	+35.26%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	3.17%	5.19M	33.74M	1.07M	+25.82%
Jun 30, 2025	SIREN, L.L.C.	2.25%	3.7M	24.03M	0	0
Jun 30, 2025	F/M INVESTMENTS LLC	0.15%	243.68K	1.58M	3.26K	+1.36%
Jun 30, 2025	IKARIAN CAPITAL, LLC	0.1%	161.14K	1.05M	161.14K	+100.00%
Jun 30, 2025	SOFINNOVA INVESTMENTS, INC.	0.07%	117.9K	766.37K	117.9K	+100.00%
Jun 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.07%	114.81K	746.29K	91.71K	+397.03%
Jun 30, 2025	COMPASS ROSE ASSET MANAGEMENT, LP	0.06%	100K	650K	100K	+100.00%
Jun 30, 2025	A16Z PERENNIAL MANAGEMENT, L.P.	0.05%	77.62K	504.52K	0	0
Jun 30, 2025	SUPERSTRING CAPITAL MANAGEMENT LP	0.04%	70.24K	456.57K	70.24K	+100.00%
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	11.1%	18.2M	118.31M	0	0
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	9.16%	15.02M	97.61M	2.5M	+19.97%
Jun 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.04%	66.19K	430.26K	-10.5K	-13.69%
Jun 30, 2025	GLENMEDE INVESTMENT MANAGEMENT, LP	0.03%	53.02K	344.64K	53.02K	+100.00%
Jun 30, 2025	VERITION FUND MANAGEMENT LLC	0.03%	52.73K	342.73K	-102.03K	-65.93%
Jun 30, 2025	STATE OF WISCONSIN INVESTMENT BOARD	0.03%	45.46K	295.48K	-60.44K	-57.08%
Jun 30, 2025	BIRCHVIEW CAPITAL, LP	0.02%	40.3K	261.95K	0	0
Jun 30, 2025	KNOTT DAVID M JR	0.02%	40K	260K	30K	+300.00%
Jun 30, 2025	MITSUBISHI UFJ KOKUSAI ASSET MANAGEMENT CO., LTD.	0.02%	36.1K	234.63K	17.42K	+93.31%
Jun 30, 2025	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.02%	36.09K	234.58K	-57.13K	-61.29%
Jun 30, 2025	HIGHVISTA STRATEGIES LLC	0.02%	35.96K	233.73K	-17.42K	-32.63%
Jun 30, 2025	NEBULA RESEARCH & DEVELOPMENT LLC	0.02%	34.34K	223.22K	2.75K	+8.70%
Jun 30, 2025	CAPTION MANAGEMENT, LLC	0.02%	34.2K	222.3K	0	0
Jun 30, 2025	BLACKROCK, INC.	6.33%	10.38M	67.49M	755.1K	+7.84%
Jun 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	3.98%	6.53M	42.45M	172.92K	+2.72%
Jun 30, 2025	M28 CAPITAL MANAGEMENT LP	3.45%	5.66M	36.82M	0	0
Jun 30, 2025	BELLEVUE GROUP AG	2.5%	4.09M	26.61M	0	0
Jun 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.22%	358.43K	2.33M	-4.13K	-1.14%
Jun 30, 2025	BARCLAYS PLC	0.35%	573.19K	3.73M	311.97K	+119.43%
Jun 30, 2025	UBS GROUP AG	0.37%	607.27K	3.95M	438.98K	+260.85%
Jun 30, 2025	FMR LLC	0.38%	619.14K	4.02M	-1.53M	-71.13%
Jun 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.18%	295.06K	1.92M	111.66K	+60.88%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.18%	297.89K	1.94M	-1.78K	-0.59%
Jun 30, 2025	PRINCIPAL FINANCIAL GROUP INC	0.18%	302.28K	1.96M	-5.77K	-1.87%
Jun 30, 2025	ENSIGN PEAK ADVISORS, INC	0.19%	313.31K	2.04M	313.31K	+100.00%
Jun 30, 2025	BAKER BROS. ADVISORS LP	0.21%	344.06K	2.24M	0	0
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.39%	645.56K	4.2M	110.3K	+20.61%
Jun 30, 2025	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.42%	683.19K	4.44M	-87.51K	-11.36%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.42%	692.42K	4.5M	666.19K	+2,540.59%
Jun 30, 2025	NORTHERN TRUST CORP	0.62%	1.01M	6.56M	37.04K	+3.81%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.62%	1.01M	6.57M	47.53K	+4.94%
Jun 30, 2025	JPMORGAN CHASE & CO	0.96%	1.57M	10.2M	390.08K	+33.09%
Jun 30, 2025	DARK FOREST CAPITAL MANAGEMENT LP	0.17%	280.77K	1.82M	83.55K	+42.36%
Jun 30, 2025	CINCTIVE CAPITAL MANAGEMENT LP	0.17%	277.76K	1.81M	277.76K	+100.00%
Jun 30, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0.09%	145.31K	944.5K	87.96K	+153.37%
Jun 30, 2025	PRIVIUM FUND MANAGEMENT B.V.	0.08%	135.55K	883.79K	22K	+19.37%
Jun 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.08%	132.89K	863.79K	86.15K	+184.28%
Jun 30, 2025	JAMES J. BURNS & COMPANY, LLC	0.07%	121.91K	792.43K	0	0
Jun 30, 2025	PFIZER INC	1.14%	1.88M	12.19M	0	0
Jun 30, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	1.18%	1.94M	12.59M	6.67K	+0.35%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.61%	1.01M	6.55B	449.44K	+80.60%
Jun 30, 2025	MORGAN STANLEY	0.94%	1.54M	10.04B	364.11K	+30.86%
Jun 30, 2025	STATE STREET CORP	1.68%	2.76M	17.92M	338.79K	+14.01%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.68%	2.76M	17.94M	166.98K	+6.44%
Jun 30, 2025	VANGUARD GROUP INC	2.12%	3.48M	22.6M	270.67K	+8.44%
Jun 30, 2025	683 CAPITAL MANAGEMENT, LLC	2.5%	4.1M	26.65M	175K	+4.46%
Jun 30, 2025	KYNAM CAPITAL MANAGEMENT, LP	2.78%	4.56M	29.64M	-339.44K	-6.93%
Jun 30, 2025	PLATINUM INVESTMENT MANAGEMENT LTD	0.22%	355.35K	2.31M	43.36K	+13.90%
Jun 30, 2025	MAVERICK CAPITAL LTD	0.22%	356.7K	2.32M	356.7K	+100.00%
Jun 30, 2025	NEWTYN MANAGEMENT, LLC	0.24%	400K	2.6M	0	0
Jun 30, 2025	MOODY ALDRICH PARTNERS LLC	0.26%	421.85K	2.74M	-17.98K	-4.09%
Jun 30, 2025	WOODLINE PARTNERS LP	0.28%	452.06K	2.94M	0	0
Jun 30, 2025	WALLEYE CAPITAL LLC	0.29%	467.89K	3.04M	77.05K	+19.71%
Jun 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.36%	591.38K	3.84M	216.52K	+57.76%
Jun 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.38%	621.38K	4.04M	142.11K	+29.65%
Jun 30, 2025	TWINBEECH CAPITAL LP	0.1%	163.75K	1.06M	-232.3K	-58.66%
Jun 30, 2025	TD ASSET MANAGEMENT INC	0.11%	179.61K	1.17M	25.2K	+16.32%
Jun 30, 2025		0.22%	358.43K	2.33M	-4.13K	-1.14%
Jun 30, 2025	D. E. SHAW & CO., INC.	0.17%	271.47K	1.76B	164.92K	+154.78%
Jun 30, 2025	AFFINITY ASSET ADVISORS, LLC	1.22%	2M	13M	175.31K	+9.61%
Jun 30, 2025	ARTISAN PARTNERS LIMITED PARTNERSHIP	1.38%	2.26M	14.72M	-105.32K	-4.44%
Jun 30, 2025	RTW INVESTMENTS, LP	0.55%	900K	5.85M	0	0
Jun 30, 2025	SUSQUEHANNA PORTFOLIO STRATEGIES, LLC	0.17%	285.09K	1.85M	270.76K	+1,889.71%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.18%	289.28K	1.88M	42.03K	+17.00%
Jun 30, 2025	STEMPOINT CAPITAL LP	0.55%	900.34K	5.85M	810.51K	+902.24%
Jun 30, 2025	POLAR CAPITAL HOLDINGS PLC	0.61%	1M	6.52M	0	0
Jun 30, 2025	BIOIMPACT CAPITAL LLC	0.92%	1.51M	9.78M	-4.32K	-0.29%
Mar 31, 2025	STATE STREET CORP	1.49%	2.42M	19.54M	-8.63K	-0.36%
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	11.2%	18.2M	147.07M	0	0
Mar 31, 2025	M28 CAPITAL MANAGEMENT LP	3.49%	5.66M	45.77M	0	0
Mar 31, 2025	KYNAM CAPITAL MANAGEMENT, LP	3.01%	4.9M	39.59M	0	0
Mar 31, 2025	EMERALD ADVISERS, LLC	1.93%	3.13M	25.32M	-28.81K	-0.91%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.6%	2.59M	20.95M	121.65K	+4.92%
Mar 31, 2025	PRIMECAP MANAGEMENT CO/CA/	1.54%	2.51M	20.26M	-12K	-0.48%
Mar 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	3.91%	6.36M	51.38M	-353.85K	-5.27%
Mar 31, 2025	RTW INVESTMENTS, LP	0.55%	900K	7.27M	0	0
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.54%	4.13M	33.33M	-973.58K	-19.09%
Mar 31, 2025	BELLEVUE GROUP AG	2.52%	4.09M	33.08M	0	0
Mar 31, 2025	683 CAPITAL MANAGEMENT, LLC	2.42%	3.93M	31.71M	140K	+3.70%
Mar 31, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.65%	1.05M	8.49M	441.48K	+72.50%
Mar 31, 2025	POLAR CAPITAL HOLDINGS PLC	0.62%	1M	8.11M	3.5K	+0.35%
Mar 31, 2025	NORTHERN TRUST CORP	0.6%	971.75K	7.85M	10K	+1.04%
Mar 31, 2025	SIREN, L.L.C.	2.27%	3.7M	29.87M	-54.17K	-1.44%
Mar 31, 2025	LOOMIS SAYLES & CO L P	1.5%	2.44M	19.69M	775.67K	+46.70%
Mar 31, 2025	PFIZER INC	1.15%	1.88M	15.15M	0	0
Mar 31, 2025	AFFINITY ASSET ADVISORS, LLC	1.12%	1.83M	14.75M	325K	+21.67%
Mar 31, 2025	BIOIMPACT CAPITAL LLC	0.93%	1.51M	12.2M	20.34K	+1.37%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.59%	963.13K	7.78M	48.66K	+5.32%
Mar 31, 2025	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.47%	770.71K	6.23M	-75.12K	-8.88%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.34%	557.64K	4.51M	20.62K	+3.84%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.33%	535.27K	4.32M	99.37K	+22.80%
Mar 31, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.29%	479.27K	4.13M	479.27K	+100.00%
Mar 31, 2025	WOODLINE PARTNERS LP	0.28%	452.06K	3.65M	247	+0.05%
Mar 31, 2025	BAKER BROS. ADVISORS LP	0.21%	344.06K	2.78M	0	0
Mar 31, 2025	PLATINUM INVESTMENT MANAGEMENT LTD	0.19%	311.99K	2.52M	0	0
Mar 31, 2025	MOODY ALDRICH PARTNERS LLC	0.27%	439.83K	3.55M	41.35K	+10.38%
Mar 31, 2025	TWINBEECH CAPITAL LP	0.24%	396.05K	3.2M	396.05K	+100.00%
Mar 31, 2025	PRINCIPAL FINANCIAL GROUP INC	0.19%	308.04K	2.49M	59.4K	+23.89%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.18%	299.67K	2.42M	-11.63K	-3.74%
Mar 31, 2025	MACQUARIE GROUP LTD	0.17%	272.33K	2.2B	38.65K	+16.54%
Mar 31, 2025	JPMORGAN CHASE & CO	0.73%	1.18M	9.53M	474.6K	+67.38%
Mar 31, 2025	NEWTYN MANAGEMENT, LLC	0.25%	400K	3.23M	-25K	-5.88%
Mar 31, 2025	ARTISAN PARTNERS LIMITED PARTNERSHIP	1.46%	2.37M	19.15M	463.36K	+24.30%
Mar 31, 2025	FMR LLC	1.32%	2.14M	17.33M	317.11K	+17.35%
Mar 31, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	1.19%	1.93M	15.6M	-214	-0.01%
Mar 31, 2025	MORGAN STANLEY	0.73%	1.18M	9.53M	121.54K	+11.48%
Mar 31, 2025	VANGUARD GROUP INC	1.97%	3.21M	25.91M	23.89K	+0.75%
Mar 31, 2025	WALLEYE CAPITAL LLC	0.24%	390.84K	3.16M	-135.86K	-25.79%
Mar 31, 2025	BARCLAYS PLC	0.16%	261.21K	2.11M	65.66K	+33.58%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.15%	247.25K	2M	2.28K	+0.93%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.15%	241.71K	1.95M	-149.91K	-38.28%
Mar 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	7.7%	12.52M	101.13M	2.89M	+30.08%
Mar 31, 2025	BLACKROCK, INC.	5.92%	9.63M	77.8M	268.45K	+2.87%
Mar 31, 2025	MAVERICK CAPITAL LTD	5.08%	8.26M	66.75M	441	+0.01%
Mar 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.23%	374.86K	3.03M	344.57K	+1,137.30%
Mar 31, 2025		0.22%	362.56K	2.93M	267	+0.07%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.22%	354.8K	2.87M	110.3K	+45.11%
Mar 31, 2024	NORTHERN TRUST CORP	0.71%	757.29K	4.67M	130.84K	+20.89%
Mar 31, 2024	FRANKLIN RESOURCES INC	0.09%	97.14K	599.37K	97.14K	+100.00%
Mar 31, 2024	TREXQUANT INVESTMENT LP	0.11%	112.63K	694.94K	80.51K	+250.67%
Mar 31, 2024	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	0.11%	113.84K	702K	113.84K	+100.00%
Mar 31, 2024	RHUMBLINE ADVISERS	0.11%	121.74K	751.14K	7.15K	+6.24%
Mar 31, 2024	CREDIT SUISSE AG/	0.12%	128.72K	794.2K	16.79K	+15.00%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.13%	134.88K	832.19K	1.47K	+1.10%
Mar 31, 2024	PRELUDE CAPITAL MANAGEMENT, LLC	0.14%	144.3K	890.33K	144.3K	+100.00%
Mar 31, 2024	SWISS NATIONAL BANK	0.15%	156.5K	965.61K	4.1K	+2.69%
Mar 31, 2024	AFFINITY ASSET ADVISORS, LLC	0.27%	286.59K	1.77M	286.59K	+100.00%
Mar 31, 2024	MARSHALL WACE, LLP	0.3%	313.41K	1.93M	-186.8K	-37.35%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.32%	336.59K	2.08M	324.69K	+2,728.48%
Mar 31, 2024	JPMORGAN CHASE & CO	0.43%	455.81K	2.81M	-6.91K	-1.49%
Mar 31, 2024	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.44%	462.58K	2.85M	462.58K	+100.00%
Mar 31, 2024	SILVERARC CAPITAL MANAGEMENT, LLC	0.47%	495.47K	3.06M	495.47K	+100.00%
Mar 31, 2024	MORGAN STANLEY	0.89%	945.12K	5.83M	754.79K	+396.57%
Mar 31, 2024	WOODLINE PARTNERS LP	0.89%	948.44K	5.85M	-443.12K	-31.84%
Mar 31, 2024	FMR LLC	1.1%	1.17M	7.21M	-33.44K	-2.78%
Mar 31, 2024	STATE STREET CORP	1.43%	1.51M	9.34M	250.69K	+19.84%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	1.54%	1.64M	10.09M	1.12M	+217.85%
Mar 31, 2024	VANGUARD GROUP INC	1.73%	1.83M	11.32M	521.67K	+39.75%
Mar 31, 2024	PRICE T ROWE ASSOCIATES INC /MD/	1.75%	1.86M	11.49M	233.89K	+14.37%
Mar 31, 2024	POINT72 ASSET MANAGEMENT, L.P.	1.86%	1.97M	12.18M	-1.24M	-38.55%
Mar 31, 2024	KYNAM CAPITAL MANAGEMENT, LP	3.71%	3.93M	24.26M	0	0
Mar 31, 2024	ARTAL GROUP S.A.	3.82%	4.05M	25M	1.04M	+34.71%
Mar 31, 2024	M28 CAPITAL MANAGEMENT LP	6.6%	7M	43.19M	-373.41K	-5.06%
Mar 31, 2024	NEWTYN MANAGEMENT, LLC	0.47%	500K	3.09M	-10K	-1.96%
Mar 31, 2024	DRIEHAUS CAPITAL MANAGEMENT LLC	0.53%	559.8K	3.45M	-27.78K	-4.73%
Mar 31, 2024	IKARIAN CAPITAL, LLC	0.56%	590.09K	3.64M	590.09K	+100.00%
Mar 31, 2024	PLATINUM INVESTMENT MANAGEMENT LTD	0.57%	600.16K	3.7M	-55.18K	-8.42%
Mar 31, 2024	GSA CAPITAL PARTNERS LLP	0.09%	95.04K	586K	95.04K	+100.00%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	1.8%	1.91M	11.8M	452.98K	+31.03%
Mar 31, 2024	PRIMECAP MANAGEMENT CO/CA/	2.71%	2.88M	17.75M	-882.97K	-23.49%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.16%	164.62K	1.02M	149.92K	+1,019.86%
Mar 31, 2024	BOOTHBAY FUND MANAGEMENT, LLC	0.16%	171.93K	1.06M	171.93K	+100.00%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.19%	197.88K	1.22M	17.46K	+9.68%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.21%	223.35K	1.38M	15.58K	+7.50%
Mar 31, 2024	JACOBS LEVY EQUITY MANAGEMENT, INC	0.23%	241.86K	1.49M	29.48K	+13.88%
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.24%	251.95K	1.55M	46.2K	+22.45%
Mar 31, 2024	D. E. SHAW & CO., INC.	0.27%	285.09K	1.76M	285.09K	+100.00%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.32%	340.68K	2.1M	-50.45K	-12.90%
Mar 31, 2024	WELLINGTON MANAGEMENT GROUP LLP	0.38%	399.1K	2.46M	125.01K	+45.61%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.39%	416.73K	2.57M	390.18K	+1,470.00%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.41%	433.58K	2.68M	263.88K	+155.51%
Mar 31, 2024	LAURION CAPITAL MANAGEMENT LP	0.82%	871.5K	5.38M	-200K	-18.67%
Mar 31, 2024	BELLEVUE GROUP AG	3.86%	4.09M	25.26M	-400K	-8.90%
Mar 31, 2024	ADAGE CAPITAL PARTNERS GP, L.L.C.	4.9%	5.2M	32.09M	-786.34K	-13.13%
Mar 31, 2024	683 CAPITAL MANAGEMENT, LLC	5.04%	5.35M	33.01M	-250K	-4.46%
Mar 31, 2024	BLACKROCK INC.	6.01%	6.38M	39.34M	1.01M	+18.80%
Mar 31, 2024	MAVERICK CAPITAL LTD	7.25%	7.69M	47.44M	-759.73K	-8.99%
Mar 31, 2024	RA CAPITAL MANAGEMENT, L.P.	17.16%	18.2M	112.31M	0	0
Mar 31, 2024	ARIZONA STATE RETIREMENT SYSTEM	0.02%	21.8K	134.48K	3.85K	+21.47%
Mar 31, 2024	KRAEMATON INVESTMENT ADVISORS, INC	0.02%	22K	135.74K	-25K	-53.19%
Mar 31, 2024	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	23.47K	145K	12.02K	+104.90%
Mar 31, 2024	WELLS FARGO & COMPANY/MN	0.02%	26.08K	160.91K	7.82K	+42.83%
Mar 31, 2024	BALYASNY ASSET MANAGEMENT L.P.	0.03%	27.54K	169.93K	-61.43K	-69.04%
Mar 31, 2024	VERITION FUND MANAGEMENT LLC	0.03%	32.96K	203.35K	32.96K	+100.00%
Mar 31, 2024	AMERICAN INTERNATIONAL GROUP, INC.	0.03%	36.24K	223.61K	6.85K	+23.31%
Mar 31, 2024	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	38.07K	234.88K	6.65K	+21.15%
Mar 31, 2024	BIRCHVIEW CAPITAL, LP	0.04%	40K	246.8K	0	0
Mar 31, 2024	BNP PARIBAS ARBITRAGE, SNC	0.04%	41.47K	255.85K	232	+0.56%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.04%	42.22K	260.52K	42.22K	+100.00%
Mar 31, 2024	INVESCO LTD.	0.04%	43.99K	271.44K	6.22K	+16.45%
Mar 31, 2024	XTX TOPCO LTD	0.04%	46.84K	288.98K	46.84K	+100.00%
Mar 31, 2024	CAPSTONE INVESTMENT ADVISORS, LLC	0.05%	54.5K	336.27K	4.5K	+9.00%
Mar 31, 2024	CORNERCAP INVESTMENT COUNSEL INC	0.05%	56.05K	345.84K	56.05K	+100.00%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.05%	58.1K	358.48K	58.1K	+100.00%
Mar 31, 2024	JUMP FINANCIAL, LLC	0.06%	59.08K	364.54K	59.08K	+100.00%
Mar 31, 2024	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.06%	65.57K	404.54K	65.57K	+100.00%
Mar 31, 2024	MARTINGALE ASSET MANAGEMENT L P	0.06%	68.9K	425.14K	97	+0.14%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.07%	71.15K	439.01M	21.8K	+44.16%
Mar 31, 2024	STRS OHIO	0.07%	71.3K	440K	-4.5K	-5.94%
Mar 31, 2024	A16Z PERENNIAL MANAGEMENT, L.P.	0.07%	77.62K	478.91K	0	0
Mar 31, 2024	MACQUARIE GROUP LTD	0.08%	81.96K	506K	0	0
Mar 31, 2024	UBS GROUP AG	0.08%	82.32K	507.92K	737	+0.90%
Dec 31, 2023	MARSHALL WACE, LLP	0.47%	500.21K	2.53M	318.57K	+175.39%
Dec 31, 2023	NEWTYN MANAGEMENT, LLC	0.48%	510K	2.58M	0	0
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	0.49%	514.58K	2.6M	259.69K	+101.88%
Dec 31, 2023	DRIEHAUS CAPITAL MANAGEMENT LLC	0.55%	587.58K	2.97M	587.58K	+100.00%
Dec 31, 2023	NORTHERN TRUST CORP	0.59%	626.45K	3.16M	111.54K	+21.66%
Dec 31, 2023	PLATINUM INVESTMENT MANAGEMENT LTD	0.62%	655.33K	3.31M	200K	+43.92%
Dec 31, 2023	LAURION CAPITAL MANAGEMENT LP	1.01%	1.07M	5.41M	200K	+22.95%
Dec 31, 2023	FMR LLC	1.13%	1.2M	6.07M	541.79K	+82.04%
Dec 31, 2023	STATE STREET CORP	1.19%	1.26M	6.38M	68.98K	+5.77%
Dec 31, 2023	VANGUARD GROUP INC	1.24%	1.31M	6.63M	129.82K	+10.98%
Dec 31, 2023	WOODLINE PARTNERS LP	1.31%	1.39M	7.03M	162.88K	+13.26%
Dec 31, 2023	MAVEN SECURITIES LTD	1.37%	1.45M	7.34B	1.45M	+100.00%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.38%	1.46M	7.37M	64.63K	+4.63%
Dec 31, 2023	PRICE T ROWE ASSOCIATES INC /MD/	1.53%	1.63M	8.22M	358.2K	+28.22%
Dec 31, 2023	CITADEL ADVISORS LLC	1.87%	1.98M	10.01M	1.98M	+100.00%
Dec 31, 2023	ARTAL GROUP S.A.	2.84%	3.01M	15.19M	1.01M	+50.37%
Dec 31, 2023	POINT72 ASSET MANAGEMENT, L.P.	3.03%	3.21M	16.23M	3.21M	+100.00%
Dec 31, 2023	PRIMECAP MANAGEMENT CO/CA/	3.55%	3.76M	18.99M	-21.1K	-0.56%
Dec 31, 2023	KYNAM CAPITAL MANAGEMENT, LP	3.71%	3.93M	19.86M	0	0
Dec 31, 2023	BELLEVUE GROUP AG	4.24%	4.49M	22.7M	0	0
Dec 31, 2023	BLACKROCK INC.	5.06%	5.37M	27.1M	502.52K	+10.33%
Dec 31, 2023	683 CAPITAL MANAGEMENT, LLC	5.28%	5.6M	28.28M	-250K	-4.27%
Dec 31, 2023	ADAGE CAPITAL PARTNERS GP, L.L.C.	5.65%	5.99M	30.24M	2.2M	+58.08%
Dec 31, 2023	M28 CAPITAL MANAGEMENT LP	6.95%	7.37M	37.24M	328.91K	+4.67%
Dec 31, 2023	MAVERICK CAPITAL LTD	7.97%	8.45M	42.66M	1.85M	+28.11%
Dec 31, 2023	RA CAPITAL MANAGEMENT, L.P.	17.17%	18.2M	91.92M	1M	+5.81%
Dec 31, 2023	STRS OHIO	0.07%	75.8K	382K	75.8K	+100.00%
Dec 31, 2023		0.07%	77.62K	391.98K	77.62K	+100.00%
Dec 31, 2023	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0.07%	78.66K	397.24K	65.61K	+502.90%
Dec 31, 2023	JANE STREET GROUP, LLC	0.07%	79.44K	401.16K	79.44K	+100.00%
Dec 31, 2023	UBS GROUP AG	0.08%	81.58K	412K	56.7K	+227.87%
Dec 31, 2023	MACQUARIE GROUP LTD	0.08%	81.96K	414K	0	0
Dec 31, 2023	BALYASNY ASSET MANAGEMENT L.P.	0.08%	88.97K	449.3K	52.62K	+144.75%
Dec 31, 2023	MONASHEE INVESTMENT MANAGEMENT LLC	0.1%	103.3K	521.67K	103.3K	+100.00%
Dec 31, 2023	CREDIT SUISSE AG/	0.11%	111.93K	565.25K	111.93K	+100.00%
Dec 31, 2023	RHUMBLINE ADVISERS	0.11%	114.6K	578.7K	3.08K	+2.77%
Dec 31, 2023	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.13%	133.41K	673.7K	51.09K	+62.06%
Dec 31, 2023	SWISS NATIONAL BANK	0.14%	152.4K	769.62K	152.4K	+100.00%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.16%	169.69K	856.95K	0	0
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.17%	180.42K	911.11K	2.89K	+1.63%
Dec 31, 2023	BARCLAYS PLC	0.17%	181.27K	917K	163.74K	+934.22%
Dec 31, 2023	MORGAN STANLEY	0.18%	190.33K	961.16K	100.46K	+111.79%
Dec 31, 2023	WS MANAGEMENT LLLP	0.18%	192.72K	973.25K	0	0
Dec 31, 2023	TD ASSET MANAGEMENT INC	0.19%	205.75K	1.04M	43.05K	+26.46%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.2%	207.77K	1.05M	-5.07K	-2.38%
Dec 31, 2023	JACOBS LEVY EQUITY MANAGEMENT, INC	0.2%	212.38K	1.07M	212.38K	+100.00%
Dec 31, 2023	WELLINGTON MANAGEMENT GROUP LLP	0.26%	274.09K	1.38M	274.09K	+100.00%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.37%	391.13K	1.98M	49.34K	+14.44%
Dec 31, 2023	WALLEYE CAPITAL LLC	0.41%	432.93K	2.19M	283.97K	+190.64%
Dec 31, 2023	JPMORGAN CHASE & CO	0.44%	462.72K	2.34M	2.15K	+0.47%

Insiders

Among the WVE insiders holding of 13.73% of the stake in company, GSK PLC, 10 percent owner, holds the largest shares of 18.25M. RA CAPITAL MANAGEMENT, L.P., , is the second largest WVE insider with ownership of 18.2M shares. RA CAPITAL MANAGEMENT, LLC, , stands third with possession of 7.78M shares of that stake.

Insiders	Designation	Shares Held
GSK PLC	10 percent owner	18.25M
RA CAPITAL MANAGEMENT, L.P.		18.2M
RA CAPITAL MANAGEMENT, LLC		7.78M
SHAH RAJEEV M.		7.09M
TAKANASHI KEN	director	5.72M
TANAKA MASAHARU		2.77M
VERDINE GREGORY L.	director	275.22K
BOLNO PAUL	President and CEO	121K
PANZARA MICHAEL A.	See Remarks	109.1K
VARGEESE CHANDRA	See Remarks	106.62K
MORAN KYLE	Chief Financial Officer	89.22K
WAGNER HEIDI L	director	44.93K
CORRIGAN MARK	director	28.82K
TAN AIK NA	director	25.4K
FRANCIS CHRIS	See Remarks	25K
REGNANTE KEITH	Chief Financial Officer	15.69K
RAWCLIFFE ADRIAN	director	12.7K
HENRY CHRISTIAN O	director	12.7K
GAIERO DAVID G	Interim CFO	6.39K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Jan 02, 2026	FRANCIS CHRIS	SALE	16.70	1.3K	21.63K	25K
Dec 11, 2025	GSK PLC	PURCHASE	19.00	1.47M	27.93M	18.25M
Dec 09, 2025	MORAN KYLE	SALE	20.25	36	729	89.22K
Dec 08, 2025	HENRY CHRISTIAN O	SALE	18.02	30K	540.6K	12.7K
Dec 08, 2025	FRANCIS CHRIS	SALE	14.50	45.88K	665.29K	25K
Dec 08, 2025	MORAN KYLE	SALE	18.00	50K	900K	89.22K
Dec 08, 2025	CORRIGAN MARK	SALE	14.06	6.52K	91.63K	28.82K
Dec 08, 2025	RAWCLIFFE ADRIAN	SALE	15.00	42K	630K	12.7K
Dec 08, 2025	WAGNER HEIDI L	SALE	14.00	7K	98K	44.93K
Dec 08, 2025	VERDINE GREGORY L.	SALE	14.05	7.98K	112.12K	275.22K
Dec 08, 2025	TAN AIK NA	SALE	12.75	21K	267.75K	25.4K
Nov 13, 2025	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	6.69	1K	6.69K	18.2M
Nov 13, 2025	RAWCLIFFE ADRIAN	SALE	6.79	16.12K	109.42K	12.7K
Aug 22, 2025	VERDINE GREGORY L.	SALE	10.00	10K	100K	285.22K
Aug 22, 2025	BOLNO PAUL	SALE	10.10	217.35K	2.19M	121K
Aug 15, 2025	TAN AIK NA	SALE	9.25	21K	194.25K	40.39K
Aug 13, 2025	HENRY CHRISTIAN O	SALE	8.81	9.67K	85.19K	29.65K
Aug 05, 2025	TAN AIK NA	SALE	8.75	1.13K	9.86K	14.99K
Aug 05, 2025	TAKANASHI KEN	SALE	8.75	4.87K	42.63K	5.72M
Jun 13, 2025	VERDINE GREGORY L.	SALE	6.95	30K	208.5K	282.52K
Mar 20, 2025	HENRY CHRISTIAN O	SALE	9.77	10.5K	102.57K	16.12K
Mar 07, 2025	BOLNO PAUL	SALE	9.57	169.03K	1.62M	338.35K
Nov 25, 2024	BOLNO PAUL	SALE	15.00	50K	750K	217.35K
Nov 15, 2024	BOLNO PAUL	SALE	14.32	51.23K	733.67K	217.35K
Nov 08, 2024	FRANCIS CHRIS	SALE	16.00	36K	576K	0
Oct 16, 2024	FRANCIS CHRIS	SALE	13.50	22.5K	303.75K	0
Oct 16, 2024	BOLNO PAUL	SALE	15.00	90.47K	1.36M	268.59K
Sep 27, 2024	GSK PLC	PURCHASE	8.00	2.79M	22.34M	16.78M
Sep 25, 2024	MORAN KYLE	SALE	9.00	17.15K	154.31K	19.78K
Aug 21, 2024	BOLNO PAUL	SALE	5.78	48.37K	279.56K	359.06K
Apr 03, 2024	MORAN KYLE	SALE	6.17	15.63K	96.42K	33.92K
Dec 11, 2023	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	5.00	1M	5M	19.2M
Dec 07, 2023	GSK PLC	PURCHASE	5.00	3.3M	16.5M	13.98M
Aug 23, 2023	MORAN KYLE	SALE	4.75	37.06K	176.12K	46.12K
Feb 16, 2023	MORAN KYLE	SALE	4.04	9.73K	39.31K	79.75K
Feb 16, 2023	BOLNO PAUL	SALE	4.04	29.4K	118.78K	407.43K
Feb 16, 2023	VARGEESE CHANDRA	SALE	4.03	10.25K	41.3K	106.62K
Feb 16, 2023	FRANCIS CHRIS	SALE	4.03	10.26K	41.34K	79.71K
Jun 16, 2022	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	0.00	7.09M	709.37	7.09M
Jun 16, 2022	SHAH RAJEEV M.	PURCHASE	2.15	7.09M	15.25M	7.09M
May 04, 2022	VARGEESE CHANDRA	SALE	1.72	16.71K	28.75K	111.1K
May 04, 2022	PANZARA MICHAEL A.	SALE	1.72	16.71K	28.75K	109.1K
May 04, 2022	MORAN KYLE	SALE	1.72	5.02K	8.64K	84.57K
May 04, 2022	FRANCIS CHRIS	SALE	1.72	10.87K	18.69K	89.97K
May 04, 2022	BOLNO PAUL	SALE	1.72	33.5K	57.62K	436.83K
Feb 16, 2022	VARGEESE CHANDRA	SALE	2.32	10.6K	24.6K	77.81K
Feb 16, 2022	MORAN KYLE	SALE	2.31	9.2K	21.26K	74.59K
Feb 16, 2022	PANZARA MICHAEL A.	SALE	2.31	10.6K	24.49K	75.82K
Feb 16, 2022	BOLNO PAUL	SALE	2.32	33.15K	76.91K	377.83K
Feb 16, 2022	FRANCIS CHRIS	SALE	2.31	10.12K	23.38K	68.34K
Feb 16, 2021	VARGEESE CHANDRA	SALE	10.57	3.15K	33.24K	85.41K
Feb 16, 2021	BOLNO PAUL	SALE	10.57	11.21K	118.44K	410.98K
Feb 16, 2021	PANZARA MICHAEL A.	SALE	10.57	2.93K	30.96K	86.42K
Feb 16, 2021	MORAN KYLE	SALE	10.57	1.72K	18.2K	69.86K
Feb 16, 2021	FRANCIS CHRIS	SALE	10.57	2.7K	28.52K	78.46K
Sep 15, 2020	BOLNO PAUL	SALE	15.00	100K	1.5M	272.18K
Aug 25, 2020	BOLNO PAUL	SALE	12.00	25K	300K	272.18K
Jul 02, 2020	BOLNO PAUL	SALE	10.27	95.92K	985.11K	272.18K
Feb 18, 2020	PANZARA MICHAEL A.	SALE	7.85	2.98K	23.4K	39.35K
Feb 18, 2020	VARGEESE CHANDRA	SALE	7.85	3.19K	25.03K	37.06K
Feb 18, 2020	BOLNO PAUL	SALE	7.85	11.45K	89.89K	319.76K
Feb 18, 2020	FRANCIS CHRIS	SALE	7.85	2.71K	21.26K	31.16K
Feb 03, 2020	GAIERO DAVID G	SALE	7.00	651	4.56K	6.39K
Dec 03, 2019	VARGEESE CHANDRA	SALE	35.00	6K	210K	40.25K
Nov 20, 2019	VERDINE GREGORY L.	SALE	32.74	2.61K	85.42K	30K
Jul 05, 2019	PANZARA MICHAEL A.	SALE	27.26	445	12.13K	42.33K
Mar 15, 2019	BOLNO PAUL	SALE	46.00	1.76K	81.1K	331.21K
Mar 11, 2019	PANZARA MICHAEL A.	SALE	48.00	7K	336K	45.39K
Feb 19, 2019	REGNANTE KEITH	SALE	36.84	1.3K	47.82K	15.69K
Feb 19, 2019	VARGEESE CHANDRA	SALE	36.84	2.06K	75.71K	25.25K
Feb 19, 2019	BOLNO PAUL	SALE	37.47	119	4.46K	271.21K
Feb 19, 2019	FRANCIS CHRIS	SALE	36.84	1.71K	62.96K	20.37K
Feb 19, 2019	PANZARA MICHAEL A.	SALE	36.84	1.84K	67.67K	37.39K
Jan 24, 2019	RA CAPITAL MANAGEMENT, LLC	PURCHASE	38.00	263.16K	10M	7.78M
Nov 14, 2018	VERDINE GREGORY L.	SALE	39.52	4.3K	169.94K	60.04K
Sep 25, 2018	FRANCIS CHRIS	SALE	56.00	10.54K	590.41K	22.08K
Sep 24, 2018	REGNANTE KEITH	SALE	55.00	29.5K	1.62M	16.98K
Sep 24, 2018	VARGEESE CHANDRA	SALE	55.00	3K	165K	27.3K
Jul 09, 2018	FRANCIS CHRIS	SALE	38.22	596	22.78K	22.08K
Jun 01, 2018	FRANCIS CHRIS	SALE	48.00	24.5K	1.18M	22.08K
May 30, 2018	FRANCIS CHRIS	SALE	45.50	24.5K	1.11M	22.08K
May 30, 2018	BOLNO PAUL	SALE	45.00	20.25K	911.25K	278.94K
May 02, 2018	BOLNO PAUL	SALE	45.00	18.29K	823.01K	278.94K
Feb 20, 2018	FRANCIS CHRIS	SALE	55.95	11.5K	643.65K	22.08K
Feb 16, 2018	PANZARA MICHAEL A.	SALE	52.10	511	26.62K	39.23K
Feb 16, 2018	BOLNO PAUL	SALE	51.62	2.2K	113.56K	278.94K
Feb 16, 2018	FRANCIS CHRIS	SALE	55.00	9.41K	517.66K	22.08K
Feb 16, 2018	REGNANTE KEITH	SALE	51.85	316	16.38K	16.98K
Feb 15, 2018	PANZARA MICHAEL A.	SALE	50.00	18.75K	937.5K	39.74K
Feb 15, 2018	VARGEESE CHANDRA	SALE	50.00	2K	100K	27.3K
Jan 23, 2018	VARGEESE CHANDRA	SALE	40.00	2K	80K	9.8K
Nov 22, 2017	VARGEESE CHANDRA	SALE	35.00	1.5K	52.5K	0
Nov 14, 2017	RA CAPITAL MANAGEMENT, LLC	PURCHASE	24.00	23.4K	561.55K	7.51M
Nov 13, 2017	RA CAPITAL MANAGEMENT, LLC	PURCHASE	23.30	400K	9.32M	7.49M
Sep 18, 2017	TANAKA MASAHARU	SALE	24.19	6.36K	153.9K	2.77M
Sep 15, 2017	TANAKA MASAHARU	SALE	24.22	14.39K	348.4K	2.78M
Jul 12, 2017	PANZARA MICHAEL A.	SALE	16.67	7.41K	123.62K	15.34K
Mar 29, 2017	TANAKA MASAHARU	SALE	24.91	433.83K	10.81M	2.79M
Jun 15, 2016	VERDINE GREGORY L.	SALE	16.70	52K	868.4K	150.08K
Nov 16, 2015	TANAKA MASAHARU	PURCHASE	16.00	76.25K	1.22M	3.23M
Nov 16, 2015	TAKANASHI KEN	PURCHASE	16.00	125K	2M	1.98M
Nov 16, 2015	RA CAPITAL MANAGEMENT, LLC	PURCHASE	16.00	1.88M	30M	7.09M
Aug 14, 2015	TAKANASHI KEN	PURCHASE	0.00	161.66K	-	161.66K
Aug 14, 2015	RA CAPITAL MANAGEMENT, LLC	PURCHASE	0.00	1.17M	-	1.17M
Aug 14, 2015	TANAKA MASAHARU	PURCHASE	0.00	161.66K	-	161.66K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE1.47M2

SALES491.84K17

NET SHARES979.16K15

SHARES HELD43.3M19

% NET SHARES-97.74%-21.05%

Frequently Asked Questions