How many institutions own TYRA stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own TYRA shares is 161, representing 104.7% of the company's common stock.

Who are the major shareholders selling Tyra Biosciences, Inc. stock?

CANAAN PARTNERS XI LLC, in the last quarter, reduced its stake in TYRA by -6.48% restricting it's holding to 3.37 million shares of worth nearly $88.71M. ALTA PARTNERS MANAGEMENT COMPANY, L.P. also lessened -6.3% of the TYRA shares from its portfolio, reducing its holding to 3.82 million shares of worth $100.52M. CITADEL ADVISORS LLC also shunned TYRA shares holding by -46.81% last quarter which brought its holding to 12.5 thousand shares worth $328.63M.

Investors who are buying TYRA stock?

As per its latest 13F filing, SIO CAPITAL MANAGEMENT, LLC increased its stake in TYRA by 2.15% in the last quarter. The institutional holder raised its holding to 526 thousand shares having worth more than $13.83M. VANGUARD GROUP INC also added 3.46% more shares of TYRA to its portfolio, raising its holding to 1.57 million shares of worth $41.35M. BLACKROCK, INC. also increased its TYRA shares holding by 11.6% which brought its holding to 2.09 million shares worth $54.85M.

TYRA's major insiders: who are they?

The insider with the most stakes in TYRA is RA CAPITAL MANAGEMENT, L.P. , at the company. Additionally, TYRA stock is highly held by 10 percent owner Boxer Capital, LLC and 10 percent owner Alta Partners NextGen Fund II Management, LLC among others.

Did an insider recently sell TYRA stock?

Company executives, directors, and other insiders own 3.19% percent of Tyra Biosciences, Inc.'s stock. Within the last six months, there have been 10 transaction(s) in which TYRA insiders have sold stock, totaling 510.19K shares. Insiders that have sold shares include BENSEN DANIEL, MORE ROBERT J, and KAPLAN GILLA.

Which insider recently purchased TYRA stock?

There have been 0 transaction(s) during the past 6-months in which Tyra Biosciences, Inc. insiders have bought stock, totalling 0 shares

How much of TYRA does insiders own?

Around 9.55M Tyra Biosciences, Inc. shares are held by insiders, which represents about 3.19% of TYRA stock.

Who is the insider with the largest stake?

TYRA , RA CAPITAL MANAGEMENT, L.P. holds the largest portfolio of the company's shares. TYRA shares owned by RA total nearly 10.26 million.

Which institution holds the most shares in TYRA?

SIO CAPITAL MANAGEMENT, LLC is the largest institutional owner in TYRA which holds 526 thousand shares worth $13.83M or 0.88% of the total TYRA shares outstanding followed by VANGUARD GROUP INC with ownership of 1.57 million shares representing 2.64% of the TYRA ownership. BLACKROCK, INC. is the third largest stakeholder with 2.09 million shares or 3.5% of the ownership worth more than $54.85M.

Is Tyra Biosciences, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the TYRA is concerned, it is a stock which is optionable.

Is there a short position on TYRA's shares?

Number of TYRA shares short is 5.92M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding TYRA shares are there?

As of today, 53.30M shares of TYRA are outstanding.

Is there many float in TYRA stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, TYRA has 17.22M shares in float.

TYRA short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for TYRA is 27.5.

Tyra Biosciences (TYRA) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares11.11

Short Percent Of Float16.27

Shares Outstanding53.30M

Shares Float17.22M

Shares Short5.92M

Short Ratio27.5

16.27%

Short % of Float

11.11%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

3.19% Percentage of Shares held by All Insiders

104.7% Percentage of Shares held by All Institutions

108.16% Percentage of Float held by Institutions

161

Number of Institutions Holding Shares

Institutional Ownership

About 104.7% of TYRA shares are held by financial institutions. SIO CAPITAL MANAGEMENT, LLC is the top corporate investor, holding 526K shares valued at $13.83M. A 0.88% stake in Tyra Biosciences, Inc. is owned by the company. VANGUARD GROUP INC owns 1.57M shares valued at $41.35M, which translates its holding of 2.64% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	SIO CAPITAL MANAGEMENT, LLC	0.88%	526K	13.83M	11.06K	+2.15%
Dec 31, 2025	VANGUARD GROUP INC	2.64%	1.57M	41.35M	52.6K	+3.46%
Dec 31, 2025	BLACKROCK, INC.	3.5%	2.09M	54.85M	216.95K	+11.60%
Dec 31, 2025	CANAAN PARTNERS XI LLC	5.65%	3.37M	88.71M	-233.78K	-6.48%
Dec 31, 2025	ALTA PARTNERS MANAGEMENT COMPANY, L.P.	6.41%	3.82M	100.52M	-256.87K	-6.30%
Dec 31, 2025	MARSHALL WACE, LLP	1.19%	711.89K	18.72M	109.88K	+18.25%
Dec 31, 2025	VIRTUS INVESTMENT ADVISERS, INC.	0.02%	11.76K	309.07K	741	+6.73%
Dec 31, 2025	CITADEL ADVISORS LLC	0.02%	12.5K	328.63M	-11K	-46.81%
Dec 31, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	15.36K	403.71K	725	+4.96%
Dec 31, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.03%	15.46K	406.31K	15.46K	+100.00%
Dec 31, 2025	DEUTSCHE BANK AG\	0.03%	16.38K	430.55K	894	+5.77%
Dec 31, 2025	VICTORY CAPITAL MANAGEMENT INC	0.03%	18.79K	493.99K	0	0
Dec 31, 2025	AQR CAPITAL MANAGEMENT LLC	0.05%	28.63K	752.71K	562	+2.00%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.05%	29.05K	763.7K	10.58K	+57.28%
Dec 31, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.05%	29.89K	785.73K	29.89K	+100.00%
Dec 31, 2025	AMERICAN CENTURY COMPANIES INC	0.08%	46.23K	1.22M	7.82K	+20.35%
Dec 31, 2025	NUVEEN, LLC	0.08%	47.35K	1.24M	-33.09K	-41.14%
Dec 31, 2025	SQUAREPOINT OPS LLC	0.09%	54.42K	1.43M	42.21K	+345.59%
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.09%	55.14K	1.45M	55.14K	+100.00%
Dec 31, 2025	UBS GROUP AG	0.1%	58.86K	1.55M	-288	-0.49%
Dec 31, 2025	TWO SIGMA ADVISERS, LP	0.1%	58.9K	1.55M	-54.3K	-47.97%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.1%	60.9K	1.6M	3.74K	+6.54%
Dec 31, 2025	JPMORGAN CHASE & CO	0.12%	71.18K	1.87M	-3.05K	-4.11%
Dec 31, 2025	BARCLAYS PLC	0.13%	76.31K	2.01M	38.68K	+102.81%
Dec 31, 2025	OPPENHEIMER & CO INC	0.14%	84.73K	2.23M	2.49K	+3.03%
Dec 31, 2025	INVESTMENT COUNSEL CO OF NEVADA	0.14%	85.02K	2.24M	0	0
Dec 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.16%	95.64K	2.51M	55.96K	+141.03%
Dec 31, 2025	TWO SIGMA INVESTMENTS, LP	0.18%	107.02K	2.81M	-92.42K	-46.34%
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	0.19%	114.39K	3.01M	-29.63K	-20.57%
Dec 31, 2025	MORGAN STANLEY	0.2%	118.9K	3.13M	-203.25K	-63.09%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.2%	120.28K	3.16M	-8.6K	-6.68%
Dec 31, 2025	RAYMOND JAMES FINANCIAL INC	0.28%	170.03K	4.47M	43.66K	+34.55%
Dec 31, 2025	NORTHERN TRUST CORP	0.34%	200.96K	5.28M	-7.53K	-3.61%
Dec 31, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.37%	221.18K	5.81M	34.51K	+18.49%
Dec 31, 2025	EVERSEPT PARTNERS, LP	0.47%	278.56K	7.32M	5.86K	+2.15%
Dec 31, 2025	BOONE CAPITAL MANAGEMENT LLC	0.67%	398.48K	10.48M	398.48K	+100.00%
Dec 31, 2025	STATE STREET CORP	1.26%	749.46K	19.7M	320.99K	+74.92%
Dec 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	1.37%	818.33K	21.51M	-28.26K	-3.34%
Dec 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	1.47%	874.19K	22.98M	592.16K	+209.96%
Dec 31, 2025	CALIGAN PARTNERS LP	1.58%	944.26K	24.82M	247.43K	+35.51%
Dec 31, 2025	5AM VENTURE MANAGEMENT, LLC	1.73%	1.03M	27.06M	90K	+9.58%
Dec 31, 2025	KYNAM CAPITAL MANAGEMENT, LP	2.62%	1.56M	41.13M	-765.51K	-32.85%
Dec 31, 2025	FARALLON CAPITAL MANAGEMENT LLC	3.46%	2.07M	54.34M	923K	+80.69%
Dec 31, 2025	BVF INC/IL	3.57%	2.13M	55.94M	-1.52M	-41.70%
Dec 31, 2025	VESTAL POINT CAPITAL, LP	4.06%	2.43M	63.75M	0	0
Dec 31, 2025	TCG CROSSOVER MANAGEMENT, LLC	4.86%	2.9M	76.19M	0	0
Dec 31, 2025	JANUS HENDERSON GROUP PLC	4.92%	2.94M	77.08M	60.64K	+2.11%
Dec 31, 2025	COMMODORE CAPITAL LP	5.66%	3.38M	88.73M	0	0
Dec 31, 2025	NEXTECH INVEST, LTD.	6.8%	4.06M	106.63M	0	0
Dec 31, 2025	RA CAPITAL MANAGEMENT, L.P.	20.44%	12.2M	320.7M	0	0
Dec 31, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	0.22%	129.75K	3.41M	-121.81K	-48.42%
Dec 31, 2025	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	0.22%	129.78K	3.41M	129.78K	+100.00%
Dec 31, 2025	AUOUR INVESTMENTS LLC	0.04%	21.02K	552.62K	0	0
Dec 31, 2025		0.12%	74.47K	1.96B	74.47K	+100.00%
Dec 31, 2025	XTX TOPCO LTD	0.05%	30.41K	799.58K	-3.29K	-9.75%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	0.06%	38.31K	1.01B	-96.01K	-71.48%
Dec 31, 2025	RHUMBLINE ADVISERS	0.07%	38.79K	1.02B	-1.85K	-4.54%
Dec 31, 2025	ALPS ADVISORS INC	0.07%	43.83K	1.15M	19.13K	+77.44%
Dec 31, 2025	Y-INTERCEPT (HONG KONG) LTD	0.08%	45.94K	1.21M	45.94K	+100.00%
Dec 31, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.21%	125K	3.29M	125K	+100.00%
Dec 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.17%	104.31K	2.74M	21.43K	+25.86%
Dec 31, 2025	INVESCO LTD.	0.22%	129.44K	3.4M	113.93K	+734.53%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	0.31%	182.39K	4.79M	82.24K	+82.11%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.33%	199.43K	5.24M	-2.16K	-1.07%
Dec 31, 2025	LOGOS GLOBAL MANAGEMENT LP	0.35%	210K	5.52M	210K	+100.00%
Dec 31, 2025	CHUNG WU INVESTMENT GROUP, LLC	0%	2K	52.58K	2K	+100.00%
Dec 31, 2025	QUEST PARTNERS LLC	0%	2.14K	56.23K	-27.92K	-92.88%
Dec 31, 2025	LEGAL & GENERAL GROUP PLC	0%	2.37K	62.23K	175	+7.98%
Dec 31, 2025	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0%	2.59K	68.2K	534	+25.92%
Dec 31, 2025	CITIGROUP INC	0.01%	3.82K	100.35K	2.11K	+123.61%
Dec 31, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.01%	6.44K	169.31K	0	0
Dec 31, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.01%	8.36K	219.71K	8.36K	+100.00%
Dec 31, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.01%	8.7K	228.64K	-645	-6.90%
Dec 31, 2025	BANK OF NOVA SCOTIA	0.02%	11.1K	291.82K	11.1K	+100.00%
Dec 31, 2025	FRANKLIN RESOURCES INC	0.02%	12.97K	340.98K	12.97K	+100.00%
Dec 31, 2025	FISHER ASSET MANAGEMENT, LLC	0.05%	28.8K	757.15K	28.8K	+100.00%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.1%	657.76K	17.3M	60.3K	+10.09%
Dec 31, 2025	SUPERSTRING CAPITAL MANAGEMENT LP	0.1%	58.68K	1.54M	58.68K	+100.00%
Dec 31, 2025	AMERITAS INVESTMENT PARTNERS, INC.	0%	1.99K	52.34K	0	0
Dec 31, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.01%	7.42K	195.15K	0	0
Dec 31, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.02%	9.8K	257.67K	-1.6K	-14.04%
Sep 30, 2025	AMERIPRISE FINANCIAL INC	0.15%	87.11K	1.22M	6.51K	+8.07%
Sep 30, 2025	TWO SIGMA ADVISERS, LP	0.19%	113.2K	1.58M	26.2K	+30.11%
Sep 30, 2025	RAYMOND JAMES FINANCIAL INC	0.21%	126.37K	1.77M	63.19K	+100.00%
Sep 30, 2025	AXA INVESTMENT MANAGERS S.A.	0.22%	128.79K	1.8M	128.79K	+100.00%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.22%	128.88K	1.8M	31.15K	+31.87%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.23%	134.32K	1.88M	-238.65K	-63.99%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.24%	144.02K	2.01M	-263.45K	-64.66%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.29%	170.1K	2.38M	35K	+25.91%
Sep 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.31%	186.67K	2.61M	186.67K	+100.00%
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.33%	199.44K	2.79M	93.61K	+88.46%
Sep 30, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	0.42%	251.56K	3.52M	-143.74K	-36.36%
Sep 30, 2025	SUSQUEHANNA PORTFOLIO STRATEGIES, LLC	0.08%	48.64K	680.53K	0	0
Sep 30, 2025	HIGHVISTA STRATEGIES LLC	0.11%	65.81K	920.71K	40.85K	+163.65%
Sep 30, 2025	NUVEEN, LLC	0.14%	80.44K	1.13M	0	0
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.07%	39.68K	555.11K	-2K	-4.80%
Sep 30, 2025	RHUMBLINE ADVISERS	0.07%	40.64K	568.49K	-49	-0.12%
Sep 30, 2025	MARSHALL WACE, LLP	1.01%	602.02K	8.42M	173.91K	+40.62%
Sep 30, 2025	JANE STREET GROUP, LLC	0.08%	44.68K	625.07M	-13.49K	-23.19%
Sep 30, 2025	NORTHERN TRUST CORP	0.35%	208.49K	2.92M	3.18K	+1.55%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.34%	201.59K	2.82M	23.48K	+13.19%
Sep 30, 2025	UBS GROUP AG	0.1%	59.14K	827.43K	12.88K	+27.83%
Sep 30, 2025	JPMORGAN CHASE & CO	0.12%	74.23K	1.04M	-28.69K	-27.87%
Sep 30, 2025	OPPENHEIMER & CO INC	0.14%	82.24K	1.15M	8.21K	+11.08%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	0.17%	100.15K	1.4M	-5.45K	-5.16%
Sep 30, 2025	PNC FINANCIAL SERVICES GROUP, INC.	0%	208	2.91K	150	+258.62%
Sep 30, 2025	GAMMA INVESTING LLC	0%	311	4.35K	96	+44.65%
Sep 30, 2025	OPTIVER HOLDING B.V.	0%	368	5.15K	368	+100.00%
Sep 30, 2025	STRS OHIO	0%	700	9.79K	0	0
Sep 30, 2025	AMALGAMATED BANK	0%	701	10K	0	0
Sep 30, 2025	VERSANT CAPITAL MANAGEMENT, INC	0%	819	11.46K	0	0
Sep 30, 2025	GF FUND MANAGEMENT CO. LTD.	0%	1.15K	16.05K	-149	-11.50%
Sep 30, 2025	CWM, LLC	0%	1.53K	21K	-12	-0.78%
Sep 30, 2025	STERLING CAPITAL MANAGEMENT LLC	0%	1.66K	23.25K	1.01K	+155.69%
Sep 30, 2025	CITIGROUP INC	0%	1.71K	23.88K	-7.79K	-82.03%
Sep 30, 2025	AMERITAS INVESTMENT PARTNERS, INC.	0%	1.99K	27.85K	0	0
Sep 30, 2025	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0%	2.06K	28.82K	6	+0.29%
Sep 30, 2025	FEDERATED HERMES, INC.	0%	2.16K	30.15K	1.84K	+586.31%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0%	2.19K	30.68K	0	0
Sep 30, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.01%	6.44K	90.1K	1.39K	+27.55%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.01%	7.42K	103.85K	0	0
Sep 30, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	9.34K	130.7K	-1.34K	-12.54%
Sep 30, 2025	SG AMERICAS SECURITIES, LLC	0.02%	9.54K	133K	9.54K	+100.00%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.02%	11.4K	159.51K	-8.52K	-42.76%
Sep 30, 2025	FMR LLC	0.02%	12.53K	175.28K	327	+2.68%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.02%	12.74K	178.25K	2.77K	+27.73%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.02%	14.63K	204.69K	0	0
Sep 30, 2025	DEUTSCHE BANK AG\	0.03%	15.48K	216.61K	2.18K	+16.41%
Sep 30, 2025	INVESCO LTD.	0.03%	15.51K	216.99K	15.51K	+100.00%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.03%	18.47K	258.4K	3.01K	+19.49%
Sep 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.03%	18.79K	262.87K	-25.4K	-57.48%
Sep 30, 2025	AUOUR INVESTMENTS LLC	0.04%	21.02K	294.07K	0	0
Sep 30, 2025	ALPS ADVISORS INC	0.04%	24.7K	345.55K	-4.03K	-14.02%
Sep 30, 2025	QUEST PARTNERS LLC	0.05%	30.06K	420.54K	-43.01K	-58.86%
Sep 30, 2025	CITADEL ADVISORS LLC	0.19%	111.29K	1.56M	-104.84K	-48.51%
Sep 30, 2025	ALLIANCEBERNSTEIN L.P.	0.06%	33.26K	465.31K	-2.38K	-6.68%
Sep 30, 2025	JUMP FINANCIAL, LLC	0.1%	62K	867.38K	-9.12K	-12.82%
Sep 30, 2025	XTX TOPCO LTD	0.06%	33.7K	471.46K	-901	-2.60%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.06%	38.41K	537.38K	9.56K	+33.13%
Sep 30, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0.07%	39.31K	549.95K	-82.73K	-67.79%
Sep 30, 2025	EVERSEPT PARTNERS, LP	0.46%	272.71K	3.82M	272.71K	+100.00%
Sep 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.47%	282.03K	3.95M	57.33K	+25.51%
Sep 30, 2025	WALLEYE CAPITAL LLC	0.5%	297.81K	4.17M	-72.6K	-19.60%
Sep 30, 2025	MORGAN STANLEY	0.54%	322.14K	4.51M	-56.26K	-14.87%
Sep 30, 2025	STATE STREET CORP	0.72%	428.47K	5.99M	9.49K	+2.26%
Sep 30, 2025	SIO CAPITAL MANAGEMENT, LLC	0.86%	514.95K	7.2M	-295.33K	-36.45%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1%	597.45K	8.36M	30.33K	+5.35%
Sep 30, 2025	CALIGAN PARTNERS LP	1.17%	696.83K	9.75M	506.88K	+266.85%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	1.42%	846.59K	11.84M	263.2K	+45.12%
Sep 30, 2025	5AM VENTURE MANAGEMENT, LLC	1.58%	939.3K	13.14M	0	0
Sep 30, 2025	FARALLON CAPITAL MANAGEMENT LLC	1.92%	1.14M	16M	0	0
Sep 30, 2025	VANGUARD GROUP INC	2.55%	1.52M	21.27M	118.49K	+8.45%
Sep 30, 2025	BLACKROCK, INC.	3.14%	1.87M	26.15M	-23.85K	-1.26%
Sep 30, 2025	KYNAM CAPITAL MANAGEMENT, LP	3.91%	2.33M	32.6M	0	0
Sep 30, 2025	VESTAL POINT CAPITAL, LP	4.07%	2.43M	33.93M	-230K	-8.66%
Sep 30, 2025	JANUS HENDERSON GROUP PLC	4.83%	2.87M	40.23M	18.51K	+0.65%
Sep 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	4.87%	2.9M	40.54M	0	0
Sep 30, 2025	COMMODORE CAPITAL LP	5.67%	3.38M	47.22M	275K	+8.87%
Sep 30, 2025	CANAAN PARTNERS XI LLC	6.06%	3.61M	50.48M	0	0
Sep 30, 2025	BVF INC/IL	6.13%	3.65M	51.06M	-294.4K	-7.46%
Sep 30, 2025	NEXTECH INVEST, LTD.	6.81%	4.06M	56.74M	0	0
Sep 30, 2025	ALTA PARTNERS MANAGEMENT COMPANY, L.P.	6.85%	4.08M	57.08M	0	0
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	20.48%	12.2M	170.66M	0	0
Sep 30, 2025	BARCLAYS PLC	0.1%	57.13K	799.19K	-4.43K	-7.20%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.1%	57.16K	799.7K	3.12K	+5.78%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.14%	82.87K	1.16M	-20.21K	-19.60%
Sep 30, 2025	INVESTMENT COUNSEL CO OF NEVADA	0.14%	85.02K	1.19M	0	0
Jun 30, 2025	ALTA PARTNERS MANAGEMENT COMPANY, L.P.	6.88%	4.08M	39.05M	0	0
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	20.56%	12.2M	116.74M	1.56M	+14.68%
Jun 30, 2025	VESTAL POINT CAPITAL, LP	4.47%	2.66M	25.41M	-224.83K	-7.81%
Jun 30, 2025	ORBIMED ADVISORS LLC	1.36%	804.6K	7.7M	-948.23K	-54.10%
Jun 30, 2025	BREVAN HOWARD CAPITAL MANAGEMENT LP	0.06%	36.59K	350.21K	-9.78K	-21.08%
Jun 30, 2025	XTX TOPCO LTD	0.06%	34.6K	331.13K	34.6K	+100.00%
Jun 30, 2025	POINT72 ASIA (SINGAPORE) PTE. LTD.	0.01%	3.49K	33.4K	2.7K	+340.66%
Jun 30, 2025	POINT72 (DIFC) LTD	0%	2.33K	22.3K	57	+2.51%
Jun 30, 2025	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0%	2.05K	19.66K	361	+21.32%
Jun 30, 2025	AMERIPRISE FINANCIAL INC	0.14%	80.6K	771.36K	80.6K	+100.00%
Jun 30, 2025	BVF INC/IL	6.65%	3.94M	37.75M	0	0
Jun 30, 2025	CANAAN PARTNERS XI LLC	6.08%	3.61M	34.53M	-536.48K	-12.94%
Jun 30, 2025	KYNAM CAPITAL MANAGEMENT, LP	3.93%	2.33M	22.3M	-76.07K	-3.16%
Jun 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.98%	583.39K	5.58M	340.14K	+139.84%
Jun 30, 2025	MARSHALL WACE, LLP	0.72%	428.11K	4.1M	47.41K	+12.45%
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.38%	224.7K	2.15M	175.1K	+353.02%
Jun 30, 2025	CALIGAN PARTNERS LP	0.32%	189.95K	1.82M	164.95K	+659.80%
Jun 30, 2025	WOODLINE PARTNERS LP	0.17%	100.11K	958.03K	0	0
Jun 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.16%	97.74K	935.33K	28.79K	+41.75%
Jun 30, 2025		0.14%	80.44K	769.82K	30.44K	+60.89%
Jun 30, 2025	STATE OF WISCONSIN INVESTMENT BOARD	0.13%	76.45K	731.62K	17.74K	+30.21%
Jun 30, 2025	OPPENHEIMER & CO INC	0.12%	74.03K	708.5K	-772	-1.03%
Jun 30, 2025	QUEST PARTNERS LLC	0.12%	73.07K	699.31K	43.45K	+146.68%
Jun 30, 2025	JUMP FINANCIAL, LLC	0.12%	71.12K	680.61K	43.17K	+154.46%
Jun 30, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.11%	67.44K	645K	37.21K	+123.06%
Jun 30, 2025	RAYMOND JAMES FINANCIAL INC	0.11%	63.19K	604.7K	8.84K	+16.27%
Jun 30, 2025	BARCLAYS PLC	0.1%	61.56K	589K	19.04K	+44.80%
Jun 30, 2025	COMMODORE CAPITAL LP	5.22%	3.1M	29.67M	2.15M	+226.32%
Jun 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	4.88%	2.9M	27.73M	0	0
Jun 30, 2025	BLACKROCK, INC.	3.19%	1.89M	18.12M	197.41K	+11.64%
Jun 30, 2025	FARALLON CAPITAL MANAGEMENT LLC	1.93%	1.14M	10.95M	0	0
Jun 30, 2025	5AM VENTURE MANAGEMENT, LLC	1.58%	939.3K	8.99M	0	0
Jun 30, 2025	SIO CAPITAL MANAGEMENT, LLC	1.37%	810.27K	7.75M	393.66K	+94.49%
Jun 30, 2025	MORGAN STANLEY	0.64%	378.4K	3.62M	197.81K	+109.54%
Jun 30, 2025	SUSQUEHANNA PORTFOLIO STRATEGIES, LLC	0.08%	48.64K	465.52K	48.64K	+100.00%
Jun 30, 2025	TREXQUANT INVESTMENT LP	0.08%	44.68K	427.6K	44.68K	+100.00%
Jun 30, 2025	PDT PARTNERS, LLC	0.07%	43.31K	414.48K	43.31K	+100.00%
Jun 30, 2025	VERITION FUND MANAGEMENT LLC	0.07%	40.94K	391.79K	-1.24K	-2.93%
Jun 30, 2025	DYNAMIC TECHNOLOGY LAB PRIVATE LTD	0.06%	34.12K	326K	34.12K	+100.00%
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	0.05%	28.85K	276.13K	5.42K	+23.14%
Jun 30, 2025	BAKER BROS. ADVISORS LP	0.02%	10.61K	101.51K	0	0
Jun 30, 2025	VIRTUS INVESTMENT ADVISERS, INC.	0.02%	9.1K	87.12K	-1.72K	-15.85%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.06%	35.64K	341.08M	18.07K	+102.85%
Jun 30, 2025	ALPS ADVISORS INC	0.05%	28.73K	274.94K	28.73K	+100.00%
Jun 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.05%	28.71K	274.77M	28.71K	+100.00%
Jun 30, 2025	TUDOR INVESTMENT CORP ET AL	0.04%	26.27K	251.36K	14.17K	+117.19%
Jun 30, 2025	HIGHVISTA STRATEGIES LLC	0.04%	24.96K	238.89K	1.02K	+4.26%
Jun 30, 2025	CORTON CAPITAL INC.	0.04%	24.35K	232.99K	24.35K	+100.00%
Jun 30, 2025	AUOUR INVESTMENTS LLC	0.04%	21.02K	201.16K	0	0
Jun 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	19.92K	190.63K	6.32K	+46.50%
Jun 30, 2025	ROYAL BANK OF CANADA	0.03%	16.21K	156K	15.54K	+2,294.83%
Jun 30, 2025	AQUATIC CAPITAL MANAGEMENT LLC	0.02%	13.74K	131.53K	1.96K	+16.66%
Jun 30, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0.02%	13.18K	126.15K	1.67K	+14.49%
Jun 30, 2025	AXQ CAPITAL, LP	0.02%	12.35K	118.19K	2.05K	+19.88%
Jun 30, 2025	FMR LLC	0.02%	12.2K	116.77M	-1.69M	-99.29%
Jun 30, 2025	WALLEYE CAPITAL LLC	0.62%	370.41K	3.54M	229.67K	+163.18%
Jun 30, 2025	NORTHERN TRUST CORP	0.35%	205.31K	1.96M	-11.14K	-5.15%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.3%	178.1K	1.7M	14K	+8.53%
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.23%	135.1K	1.29M	83.7K	+162.84%
Jun 30, 2025	AXA S.A.	0.22%	128.4K	1.23M	211	+0.16%
Jun 30, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0.21%	122.04K	1.17M	30.19K	+32.87%
Jun 30, 2025	TWO SIGMA INVESTMENTS, LP	0.18%	105.83K	1.01M	41.01K	+63.26%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.18%	105.6K	1.01M	27.59K	+35.37%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.17%	103.08K	986.46K	-1.01K	-0.97%
Jun 30, 2025	JPMORGAN CHASE & CO	0.17%	102.92K	984.92K	17.43K	+20.38%
Jun 30, 2025	TWO SIGMA ADVISERS, LP	0.15%	87K	832.59K	36.9K	+73.65%
Jun 30, 2025	JANUS HENDERSON GROUP PLC	4.81%	2.86M	27.29M	163.05K	+6.05%
Jun 30, 2025	VANGUARD GROUP INC	2.36%	1.4M	13.41M	183.32K	+15.05%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.96%	567.13K	5.43M	50.84K	+9.85%
Jun 30, 2025	STATE STREET CORP	0.71%	418.98K	4.01M	5K	+1.21%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.69%	407.46K	3.9M	3.3K	+0.82%
Jun 30, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	0.67%	395.3K	3.78M	93.5K	+30.98%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.63%	372.97K	3.57M	289.45K	+346.55%
Jun 30, 2025	CITADEL ADVISORS LLC	0.36%	216.14K	2.07M	119.85K	+124.48%
Jun 30, 2025	NEXTECH INVEST, LTD.	6.84%	4.06M	38.81B	0	0
Jun 30, 2025	INVESTMENT COUNSEL CO OF NEVADA	0.14%	85.02K	813.64K	0	0
Jun 30, 2025	NUVEEN, LLC	0.14%	80.44K	769.82K	30.44K	+60.89%
Mar 31, 2025	COMMODORE CAPITAL LP	1.6%	950K	8.84M	950K	+100.00%
Mar 31, 2025	JPMORGAN CHASE & CO	0.14%	85.49K	795.06K	-5.63K	-6.17%
Mar 31, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0.15%	91.84K	854.15K	-17.9K	-16.31%
Mar 31, 2025	AXA S.A.	0.22%	128.19K	1.19M	128.19K	+100.00%
Mar 31, 2025	WALLEYE CAPITAL LLC	0.24%	140.74K	1.31M	77.76K	+123.47%
Mar 31, 2025	POLAR ASSET MANAGEMENT PARTNERS INC.	0.24%	141.24K	1.31M	30.13K	+27.12%
Mar 31, 2025	MORGAN STANLEY	0.3%	180.59K	1.68M	106.44K	+143.55%
Mar 31, 2025	NORTHERN TRUST CORP	0.36%	216.45K	2.01M	-6.32K	-2.84%
Mar 31, 2025	TCG CROSSOVER MANAGEMENT, LLC	4.88%	2.9M	26.95M	909K	+45.70%
Mar 31, 2025	VESTAL POINT CAPITAL, LP	4.85%	2.88M	26.78M	1.89M	+190.89%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.18%	104.09K	968.01K	9.23K	+9.73%
Mar 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.41%	243.24K	2.26M	243.24K	+100.00%
Mar 31, 2025	JACOBS LEVY EQUITY MANAGEMENT, INC	0.51%	301.8K	2.81M	57.56K	+23.56%
Mar 31, 2025	MARSHALL WACE, LLP	0.64%	380.7K	3.54M	326.62K	+604.00%
Mar 31, 2025	BLACKROCK, INC.	2.86%	1.7M	15.77M	-22.59K	-1.31%
Mar 31, 2025	FMR LLC	2.88%	1.71M	15.88M	-1.4M	-45.07%
Mar 31, 2025	ORBIMED ADVISORS LLC	2.95%	1.75M	16.3M	282.75K	+19.23%
Mar 31, 2025	CANAAN PARTNERS XI LLC	6.98%	4.14M	38.54M	-35.27K	-0.84%
Mar 31, 2025	STATE STREET CORP	0.7%	413.99K	3.85M	6.42K	+1.57%
Mar 31, 2025	BREVAN HOWARD CAPITAL MANAGEMENT LP	0.08%	46.37K	431.25K	46.37K	+100.00%
Mar 31, 2025	STATE OF WISCONSIN INVESTMENT BOARD	0.1%	58.71K	546.02K	-6.33K	-9.73%
Mar 31, 2025	CITADEL ADVISORS LLC	0.16%	96.28K	895.42K	40.7K	+73.21%
Mar 31, 2025	WOODLINE PARTNERS LP	0.17%	100.11K	931K	100.11K	+100.00%
Mar 31, 2025	ALLY BRIDGE GROUP (NY) LLC	0.18%	107.24K	997.37K	-67.82K	-38.74%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.68%	404.17K	3.76M	89.02K	+28.25%
Mar 31, 2025	SIO CAPITAL MANAGEMENT, LLC	0.7%	416.62K	3.87M	175.75K	+72.96%
Mar 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.77%	459.11K	4.27M	105.1K	+29.69%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.87%	516.29K	4.8M	-1.29K	-0.25%
Mar 31, 2025	FARALLON CAPITAL MANAGEMENT LLC	1.93%	1.14M	10.64M	142.84K	+14.27%
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	17.93%	10.64M	98.93M	0	0
Mar 31, 2025	TWO SIGMA ADVISERS, LP	0.08%	50.1K	465.93K	37.8K	+307.32%
Mar 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.08%	49.6K	461.28K	36.82K	+288.02%
Mar 31, 2025	UBS GROUP AG	0.08%	46.29K	430.46K	-1.57K	-3.27%
Mar 31, 2025	BARCLAYS PLC	0.07%	42.51K	395K	-559	-1.30%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.28%	164.11K	1.53M	-6.49K	-3.81%
Mar 31, 2025	KYNAM CAPITAL MANAGEMENT, LP	4.05%	2.41M	22.38M	1.88M	+353.57%
Mar 31, 2025	JANUS HENDERSON GROUP PLC	4.54%	2.69M	26.31M	946.92K	+54.22%
Mar 31, 2025	BVF INC/IL	6.65%	3.94M	36.68M	0	0
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.09%	51.4K	478.02K	22.3K	+76.63%
Mar 31, 2025	RAYMOND JAMES FINANCIAL INC	0.09%	54.34K	505.4K	-439	-0.80%
Mar 31, 2025	VICTORY CAPITAL MANAGEMENT INC	0.09%	56.15K	522.2K	-490	-0.87%
Mar 31, 2025		0.08%	50K	464.98K	50K	+100.00%
Mar 31, 2025	VANGUARD GROUP INC	2.05%	1.22M	11.33M	10.61K	+0.88%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.11%	64.82K	602.81K	18.55K	+40.09%
Mar 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.12%	68.95K	641.24K	64.63K	+1,496.80%
Mar 31, 2025	OPPENHEIMER & CO INC	0.13%	74.81K	695.69K	-634	-0.84%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.13%	78.01K	725.46K	13.9K	+21.68%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.14%	83.52K	776.75K	17.36K	+26.25%
Mar 31, 2024	SEPIO CAPITAL, LP	0%	0	-	-10.63K	-100.00%
Mar 31, 2024	FISHMAN JAY A LTD/MI	0.03%	15K	246K	15K	+100.00%
Mar 31, 2024	JUMP FINANCIAL, LLC	0.04%	15.16K	248.61K	15.16K	+100.00%
Mar 31, 2024	EXCHANGE TRADED CONCEPTS, LLC	0.04%	16.05K	263.27K	6.52K	+68.43%
Mar 31, 2024	WALLEYE CAPITAL LLC	0.04%	16.89K	276.95K	16.89K	+100.00%
Mar 31, 2024	MARSHALL WACE, LLP	0.05%	19.64K	322.15K	-10.36K	-34.53%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.06%	24.94K	408.97K	14.06K	+129.20%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.06%	25.71K	421.69K	0	0
Mar 31, 2024	ADAR1 CAPITAL MANAGEMENT, LLC	0.07%	28.3K	464.12K	28.3K	+100.00%
Mar 31, 2024	NEW YORK STATE COMMON RETIREMENT FUND	0.07%	32.15K	527K	28.12K	+697.54%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.08%	33.03K	541.73K	10.91K	+49.34%
Mar 31, 2024	MORGAN STANLEY	0.08%	35.24K	577.89K	-431	-1.21%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.1%	41.74K	684.57K	41.74K	+100.00%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.1%	43.74K	717.25K	1.79K	+4.27%
Mar 31, 2024	VICTORY CAPITAL MANAGEMENT INC	0.11%	48.09K	788.68K	-2.13K	-4.24%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.13%	54.4K	892K	54.4K	+100.00%
Mar 31, 2024	OPPENHEIMER & CO INC	0.14%	59.58K	977.05K	59.58K	+100.00%
Mar 31, 2024	AUOUR INVESTMENTS LLC	0.2%	85.02K	1.39M	0	0
Mar 31, 2024	WELLINGTON MANAGEMENT GROUP LLP	0.24%	101.79K	1.67M	-648	-0.63%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.35%	152.21K	2.5M	41.68K	+37.70%
Mar 31, 2024	NICHOLAS INVESTMENT PARTNERS, LP	0.36%	152.97K	2.51M	152.97K	+100.00%
Mar 31, 2024	NORTHERN TRUST CORP	0.36%	156.47K	2.57M	4.22K	+2.77%
Mar 31, 2024	STATE STREET CORP	0.68%	292.23K	4.79M	26.88K	+10.13%
Mar 31, 2024	JPMORGAN CHASE & CO	0.89%	380.6K	6.24M	-21.11K	-5.25%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	0.97%	416.81K	6.84M	83.34K	+24.99%
Mar 31, 2024	KYNAM CAPITAL MANAGEMENT, LP	1.2%	515.19K	8.45M	175K	+51.44%
Mar 31, 2024	SIO CAPITAL MANAGEMENT, LLC	1.25%	535.74K	8.79M	535.74K	+100.00%
Mar 31, 2024	PERCEPTIVE ADVISORS LLC	1.56%	669.16K	10.97M	309.16K	+85.88%
Mar 31, 2024	ORBIMED ADVISORS LLC	1.79%	768.64K	12.61M	768.64K	+100.00%
Mar 31, 2024	AJOVISTA, LLC	0%	0	-	-4.24K	-100.00%
Mar 31, 2024	UBS GROUP AG	0.03%	14.17K	232.42K	9.2K	+184.75%
Mar 31, 2024	BELVEDERE TRADING LLC	0%	0	-	-14.4K	-100.00%
Mar 31, 2024	LPL FINANCIAL LLC	0%	0	-	-10.5K	-100.00%
Mar 31, 2024	NELSON, VAN DENBURG & CAMPBELL WEALTH MANAGEMENT GROUP, LLC	0%	2	32	2	+100.00%
Mar 31, 2024	GAMMA INVESTING LLC	0%	16	262	0	0
Mar 31, 2024	NISA INVESTMENT ADVISORS, LLC	0%	34	558	18	+112.50%
Mar 31, 2024	PNC FINANCIAL SERVICES GROUP, INC.	0%	58	951	0	0
Mar 31, 2024	SIMPLEX TRADING, LLC	0%	100	1K	100	+100.00%
Mar 31, 2024	RUSSELL INVESTMENTS GROUP, LTD.	0%	126	2.07K	107	+563.16%
Mar 31, 2024	AMALGAMATED BANK	0%	424	7K	-1.02K	-70.66%
Mar 31, 2024	STRS OHIO	0%	700	11K	700	+100.00%
Mar 31, 2024	FEDERATED HERMES, INC.	0%	713	11.69K	-1.36K	-65.56%
Mar 31, 2024	METROPOLITAN LIFE INSURANCE CO/NY	0%	814	13.35K	0	0
Mar 31, 2024	AMERITAS INVESTMENT PARTNERS, INC.	0%	940	15.42M	0	0
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0%	1.27K	20.75M	0	0
Mar 31, 2024	ENTRYPOINT CAPITAL, LLC	0%	1.35K	22.06K	1.35K	+100.00%
Mar 31, 2024	WELLS FARGO & COMPANY/MN	0.01%	4.73K	77.49K	652	+16.01%
Mar 31, 2024	AMERICAN INTERNATIONAL GROUP, INC.	0.02%	6.89K	113.03K	-59	-0.85%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.02%	7.03K	115.33K	4.38K	+165.06%
Mar 31, 2024	CITIGROUP INC	0.02%	7.11K	116.54K	5.08K	+249.88%
Mar 31, 2024	METLIFE INVESTMENT MANAGEMENT, LLC	0.02%	7.7K	126.31K	0	0
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	0.03%	10.75K	176.3K	141	+1.33%
Mar 31, 2024	FIRST TURN MANAGEMENT, LLC	0.89%	381.21K	6.25M	381.21K	+100.00%
Mar 31, 2024	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	1.94%	832.22K	13.65M	-194.2K	-18.92%
Mar 31, 2024	VANGUARD GROUP INC	2.09%	899.8K	14.76M	140.83K	+18.56%
Mar 31, 2024	BLACKROCK INC.	2.43%	1.04M	17.13M	79.19K	+8.21%
Mar 31, 2024	FAIRMOUNT FUNDS MANAGEMENT LLC	3.24%	1.39M	22.85M	0	0
Mar 31, 2024	TCG CROSSOVER MANAGEMENT, LLC	4.63%	1.99M	32.62M	0	0
Mar 31, 2024	NEXTECH INVEST LTD.	9.44%	4.06M	66.52M	1.54M	+61.04%
Mar 31, 2024	CANAAN PARTNERS XI LLC	10.26%	4.41M	72.32M	0	0
Mar 31, 2024	BVF INC/IL	10.85%	4.66M	76.44M	1.92M	+70.14%
Mar 31, 2024	BOXER CAPITAL, LLC	15.01%	6.45M	105.75M	0	0
Mar 31, 2024	RA CAPITAL MANAGEMENT, L.P.	24.24%	10.42M	170.83M	3.18M	+43.95%
Mar 31, 2024	5AM VENTURE MANAGEMENT, LLC	2.19%	939.3K	15.4M	384.32K	+69.25%
Mar 31, 2024	CITADEL ADVISORS LLC	0.04%	16.79K	275.34K	16.79K	+100.00%
Mar 31, 2024	LEGATO CAPITAL MANAGEMENT LLC	0.05%	20.26K	332.25K	20.26K	+100.00%
Mar 31, 2024	RHUMBLINE ADVISERS	0.05%	21K	344.36K	-334	-1.57%
Mar 31, 2024	DRIEHAUS CAPITAL MANAGEMENT LLC	0.47%	203.71K	3.34M	0	0
Mar 31, 2024	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.63%	272.15K	4.46M	272.15K	+100.00%
Mar 31, 2024	FMR LLC	9.26%	3.98M	65.23M	1.21M	+43.65%
Mar 31, 2024	PDT PARTNERS, LLC	0.03%	12.17K	199.65K	12.17K	+100.00%
Mar 31, 2024	HUDSON BAY CAPITAL MANAGEMENT LP	0.03%	13.32K	218.4K	13.32K	+100.00%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.03%	14.08K	230.86K	14.08K	+100.00%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	0.78%	333.47K	4.62M	18.99K	+6.04%
Dec 31, 2023	SEPIO CAPITAL, LP	0.02%	10.63K	147.16K	0	0
Dec 31, 2023	PERCEPTIVE ADVISORS LLC	0.84%	360K	4.99M	0	0
Dec 31, 2023	JPMORGAN CHASE & CO	0.94%	401.71K	5.56M	4.09K	+1.03%
Dec 31, 2023	KYNAM CAPITAL MANAGEMENT, LP	0.79%	340.19K	4.71M	340.19K	+100.00%
Dec 31, 2023	IKARIAN CAPITAL, LLC	0.11%	48.17K	667.16K	0	0
Dec 31, 2023	5AM VENTURE MANAGEMENT, LLC	1.29%	554.98K	7.69M	143.53K	+34.88%
Dec 31, 2023	VANGUARD GROUP INC	1.77%	758.97K	10.51M	26.38K	+3.60%
Dec 31, 2023	BLACKROCK INC.	2.25%	965.03K	13.37M	68.58K	+7.65%
Dec 31, 2023	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	2.39%	1.03M	14.22M	-1.59K	-0.16%
Dec 31, 2023	FAIRMOUNT FUNDS MANAGEMENT LLC	3.25%	1.39M	19.3M	0	0
Dec 31, 2023	TCG CROSSOVER MANAGEMENT, LLC	4.64%	1.99M	27.55M	0	0
Dec 31, 2023	NEXTECH INVEST LTD.	5.88%	2.52M	34.88M	0	0
Dec 31, 2023	BVF INC/IL	6.39%	2.74M	37.94M	0	0
Dec 31, 2023	VICTORY CAPITAL MANAGEMENT INC	0.12%	50.22K	695.55K	17.49K	+53.44%
Dec 31, 2023	RA CAPITAL MANAGEMENT, L.P.	16.88%	7.24M	100.22M	0	0
Dec 31, 2023	FMR LLC	6.46%	2.77M	38.35M	-1.13M	-28.99%
Dec 31, 2023	CANAAN PARTNERS XI LLC	10.29%	4.41M	61.08M	0	0
Dec 31, 2023	BOXER CAPITAL, LLC	15.04%	6.45M	89.31M	0	0
Dec 31, 2023		0.01%	4.24K	58.66K	4.24K	+100.00%
Dec 31, 2023	WELLINGTON MANAGEMENT GROUP LLP	0.24%	102.44K	1.42M	102.44K	+100.00%
Dec 31, 2023	AMERICAN CENTURY COMPANIES INC	0.03%	10.88K	150.69K	10.88K	+100.00%
Dec 31, 2023	BELVEDERE TRADING LLC	0.03%	14.4K	199.44K	14.4K	+100.00%
Dec 31, 2023	NEW YORK STATE COMMON RETIREMENT FUND	0.01%	4.03K	56K	-15	-0.37%
Dec 31, 2023	WELLS FARGO & COMPANY/MN	0.01%	4.07K	56.41K	843	+26.10%
Dec 31, 2023	ROYAL BANK OF CANADA	0.01%	4.24K	58K	2.11K	+98.88%
Dec 31, 2023	UBS GROUP AG	0.01%	4.98K	68.93K	-333	-6.27%
Dec 31, 2023	DEUTSCHE BANK AG\	0.01%	6.22K	86.19K	0	0
Dec 31, 2023	AMERICAN INTERNATIONAL GROUP, INC.	0.02%	6.95K	96.27K	-29	-0.42%
Dec 31, 2023	METLIFE INVESTMENT MANAGEMENT, LLC	0.02%	7.7K	106.67K	0	0
Dec 31, 2023	ACUTA CAPITAL PARTNERS, LLC	0.02%	8.87K	122.81K	8.87K	+100.00%
Dec 31, 2023	BARCLAYS PLC	0.04%	19.23K	266K	16.72K	+667.24%
Dec 31, 2023	RHUMBLINE ADVISERS	0.05%	21.33K	295.44K	-129	-0.60%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.05%	22.12K	306.33K	-46	-0.21%
Dec 31, 2023	MARINER, LLC	0.05%	22.16K	306.97K	-2.13K	-8.78%
Dec 31, 2023	EXCHANGE TRADED CONCEPTS, LLC	0.02%	9.53K	132K	2.42K	+33.98%
Dec 31, 2023	ARTIA GLOBAL PARTNERS LP	0.02%	10.25K	142K	-35K	-77.34%
Dec 31, 2023	LPL FINANCIAL LLC	0.02%	10.5K	145.43K	-4K	-27.59%
Dec 31, 2023	BAKER BROS. ADVISORS LP	0.02%	10.61K	146.91K	10.61K	+100.00%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	0.02%	10.61K	146.94K	0	0
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.26%	110.54K	1.53M	323	+0.29%
Dec 31, 2023	ECOR1 CAPITAL, LLC	0.32%	137.01K	1.9M	137.01K	+100.00%
Dec 31, 2023	NORTHERN TRUST CORP	0.36%	152.25K	2.11M	10.65K	+7.52%
Dec 31, 2023	DRIEHAUS CAPITAL MANAGEMENT LLC	0.48%	203.71K	2.82M	53.24K	+35.38%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.06%	25.71K	356.13K	6.96K	+37.09%
Dec 31, 2023	MARSHALL WACE, LLP	0.07%	30K	415.51K	30K	+100.00%
Dec 31, 2023	MORGAN STANLEY	0.08%	35.67K	494K	17.38K	+95.08%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.1%	41.95K	580.94K	75	+0.18%
Dec 31, 2023	STATE STREET CORP	0.62%	265.35K	3.68M	5.9K	+2.27%

Insiders

Among the TYRA insiders holding of 3.19% of the stake in company, RA CAPITAL MANAGEMENT, L.P., , holds the largest shares of 10.26M. BOXER CAPITAL, LLC, 10 percent owner, is the second largest TYRA insider with ownership of 6.45M shares. ALTA PARTNERS NEXTGEN FUND II MANAGEMENT, LLC, 10 percent owner, stands third with possession of 4.08M shares of that stake.

Insiders	Designation	Shares Held
RA CAPITAL MANAGEMENT, L.P.		10.26M
BOXER CAPITAL, LLC	10 percent owner	6.45M
ALTA PARTNERS NEXTGEN FUND II MANAGEMENT, LLC	10 percent owner	4.08M
MORE ROBERT J	director	3.82M
HARRIS TODD	President and CEO	1.36M
CORMORANT ASSET MANAGEMENT, LP		1.07M
KJELLSON NINA S	director	443.89K
BENSEN DANIEL	Chief Discovery Officer	146.98K
KAPLAN GILLA	director	28.23K
MVA INVESTORS, LLC	10 percent owner	22.53K
FUHRMAN ALAN	Chief Financial Officer	12.85K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Feb 12, 2026	BENSEN DANIEL	SALE	33.37	5.87K	195.93K	146.98K
Jan 12, 2026	BENSEN DANIEL	SALE	29.08	1.02K	29.58K	154.98K
Dec 19, 2025	MORE ROBERT J	SALE	25.00	10K	250K	3.82M
Dec 12, 2025	BENSEN DANIEL	SALE	22.64	8K	181.16K	162.98K
Nov 21, 2025	MORE ROBERT J	SALE	20.25	246.87K	5M	3.83M
Nov 19, 2025	BENSEN DANIEL	SALE	16.32	49.96K	815.3K	170.98K
Nov 18, 2025	BENSEN DANIEL	SALE	16.07	75.63K	1.22M	220.94K
Nov 17, 2025	BENSEN DANIEL	SALE	17.07	1.5K	25.61K	296.57K
Nov 14, 2025	BENSEN DANIEL	SALE	16.02	110.23K	1.77M	316.64K
Nov 13, 2025	BENSEN DANIEL	SALE	16.00	1.11K	17.78K	426.87K
Jun 18, 2025	KAPLAN GILLA	SALE	9.78	9.57K	93.6K	28.23K
Jun 17, 2025	KAPLAN GILLA	SALE	10.35	10	103.5	37.8K
Jun 16, 2025	KAPLAN GILLA	SALE	10.38	6.81K	70.73K	37.81K
Jun 16, 2025	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	10.13	11.81K	119.67K	10.26M
Jun 13, 2025	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	10.20	120.17K	1.23M	10.25M
Jun 13, 2025	KAPLAN GILLA	SALE	10.31	15K	154.58K	44.62K
Jun 12, 2025	KAPLAN GILLA	SALE	10.31	30K	309.26K	59.62K
Jun 12, 2025	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	10.20	31.31K	319.33K	10.13M
Jun 09, 2025	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	10.19	186.85K	1.9M	10.1M
Jun 05, 2025	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	10.04	213.33K	2.14M	9.91M
Jun 04, 2025	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	9.63	997.86K	9.61M	9.7M
Feb 05, 2025	KJELLSON NINA S	SALE	13.76	3.51K	48.32K	443.89K
Jan 23, 2025	KJELLSON NINA S	SALE	16.26	4.83K	78.47K	3.7M
Jan 21, 2025	KJELLSON NINA S	SALE	16.36	3.99K	65.34K	3.71M
Jan 17, 2025	KJELLSON NINA S	SALE	16.40	461	7.56K	447.4K
Jan 16, 2025	KJELLSON NINA S	SALE	16.29	835	13.6K	447.86K
Nov 25, 2024	KJELLSON NINA S	SALE	16.84	566	9.53K	448.69K
Nov 08, 2024	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	16.25	1.22M	19.84M	8.7M
Nov 07, 2024	KJELLSON NINA S	SALE	17.32	2.37K	41.06K	449.26K
Nov 06, 2024	KJELLSON NINA S	SALE	17.18	5.64K	96.78K	451.63K
Nov 05, 2024	KJELLSON NINA S	SALE	16.77	1.13K	18.88K	457.26K
Nov 04, 2024	KJELLSON NINA S	SALE	17.01	116	1.97K	458.39K
Nov 01, 2024	KJELLSON NINA S	SALE	17.16	73	1.25K	458.51K
Oct 31, 2024	KJELLSON NINA S	SALE	16.46	10.75K	176.94K	461.46K
Oct 30, 2024	FUHRMAN ALAN	PURCHASE	16.00	9.5K	151.95K	12.85K
Oct 30, 2024	KJELLSON NINA S	SALE	16.17	1.19K	19.22K	472.21K
Oct 21, 2024	HARRIS TODD	SALE	28.16	13.19K	371.37K	1.36M
Oct 18, 2024	HARRIS TODD	SALE	27.01	43.64K	1.18M	1.38M
Oct 17, 2024	HARRIS TODD	SALE	26.37	200	5.27K	1.42M
Oct 16, 2024	HARRIS TODD	SALE	26.98	3.92K	105.81K	1.43M
Oct 15, 2024	HARRIS TODD	SALE	24.31	10.04K	243.97K	1.47M
Sep 30, 2024	HARRIS TODD	SALE	24.00	500	12K	1.48M
Sep 25, 2024	HARRIS TODD	SALE	24.01	600	14.41K	1.48M
Sep 24, 2024	HARRIS TODD	SALE	24.02	1.06K	25.34K	1.48M
Sep 23, 2024	HARRIS TODD	SALE	24.13	10.09K	243.48K	1.48M
Sep 20, 2024	HARRIS TODD	SALE	24.19	7.11K	171.95K	1.49M
Sep 19, 2024	HARRIS TODD	SALE	25.10	27	677.62	1.5M
Sep 18, 2024	HARRIS TODD	SALE	24.00	3.5K	84K	1.5M
Jun 10, 2024	BENSEN DANIEL	SALE	20.00	3.5K	70.04K	427.98K
Jun 07, 2024	BENSEN DANIEL	SALE	20.00	200	4K	431.48K
Mar 11, 2024	BENSEN DANIEL	SALE	20.00	200	4K	431.68K
Mar 07, 2024	BENSEN DANIEL	SALE	20.00	68	1.36K	431.88K
Mar 06, 2024	BENSEN DANIEL	SALE	20.09	1.73K	34.82K	431.95K
Mar 05, 2024	BENSEN DANIEL	SALE	20.02	1.19K	23.8K	433.68K
Mar 04, 2024	BENSEN DANIEL	SALE	20.08	5.06K	101.65K	434.87K
Mar 01, 2024	BENSEN DANIEL	SALE	20.04	2.9K	58.11K	439.94K
Feb 29, 2024	BENSEN DANIEL	SALE	20.00	2.05K	41K	442.84K
Feb 28, 2024	BENSEN DANIEL	SALE	20.13	5.85K	117.73K	444.89K
Feb 27, 2024	BENSEN DANIEL	SALE	20.00	745	14.9K	450.74K
Feb 12, 2024	BENSEN DANIEL	SALE	20.00	1.5K	30.02K	451.48K
Feb 07, 2024	BENSEN DANIEL	SALE	18.09	9.59K	173.47K	452.98K
Feb 06, 2024	BENSEN DANIEL	SALE	18.09	15.41K	278.83K	462.57K
Feb 05, 2024	HARRIS TODD	SALE	16.97	13.82K	234.43K	1.5M
Feb 02, 2024	BENSEN DANIEL	SALE	17.04	2.3K	39.2K	477.98K
Feb 02, 2024	HARRIS TODD	SALE	17.04	7.19K	122.49K	1.52M
Jul 21, 2023	BENSEN DANIEL	SALE	16.01	3.9K	62.43K	527.98K
Jul 19, 2023	BENSEN DANIEL	SALE	16.07	207	3.33K	527.98K
Jul 17, 2023	BENSEN DANIEL	SALE	16.03	1.9K	30.46K	527.98K
Jul 13, 2023	BENSEN DANIEL	SALE	16.13	500	8.07K	527.98K
Jul 12, 2023	BENSEN DANIEL	SALE	16.23	201	3.26K	527.98K
Jul 11, 2023	BENSEN DANIEL	SALE	16.02	500	8.01K	527.98K
Jul 10, 2023	BENSEN DANIEL	SALE	16.01	1.2K	19.24K	527.98K
Jul 03, 2023	BENSEN DANIEL	SALE	17.04	400	6.81K	527.98K
Jun 30, 2023	BENSEN DANIEL	SALE	16.97	18.82K	319.42K	527.98K
Jun 29, 2023	BENSEN DANIEL	SALE	16.49	17.28K	285.01K	527.98K
Jun 28, 2023	BENSEN DANIEL	SALE	16.91	13.52K	228.64K	527.98K
Jun 27, 2023	BENSEN DANIEL	SALE	17.09	8.14K	139.02K	527.98K
Jun 26, 2023	BENSEN DANIEL	SALE	17.24	6.37K	109.79K	527.98K
Jun 23, 2023	HARRIS TODD	SALE	17.51	6.48K	113.46K	1.6M
Jun 22, 2023	HARRIS TODD	SALE	17.39	500	8.69K	1.62M
Jun 21, 2023	HARRIS TODD	SALE	18.18	1.1K	20K	1.63M
Jun 20, 2023	HARRIS TODD	SALE	16.53	1.3K	21.49K	1.65M
Jun 16, 2023	HARRIS TODD	SALE	18.50	600	11.1K	1.65M
Jun 15, 2023	HARRIS TODD	SALE	16.13	12.77K	206K	1.7M
Jun 15, 2023	BENSEN DANIEL	SALE	16.15	12.59K	203.3K	527.98K
Jun 14, 2023	BENSEN DANIEL	SALE	16.45	120	1.97K	527.98K
Jun 13, 2023	BENSEN DANIEL	SALE	16.01	5.63K	90.13K	527.98K
Jun 13, 2023	HARRIS TODD	SALE	16.00	7.93K	126.87K	1.7M
Apr 03, 2023	HARRIS TODD	SALE	16.13	2K	32.25K	1.7M
Apr 03, 2023	BENSEN DANIEL	SALE	16.16	2K	32.31K	527.98K
Mar 31, 2023	BENSEN DANIEL	SALE	16.00	400	6.4K	527.98K
Mar 31, 2023	HARRIS TODD	SALE	16.05	500	8.02K	1.7M
Mar 30, 2023	HARRIS TODD	SALE	16.02	2.41K	38.55K	1.7M
Mar 30, 2023	BENSEN DANIEL	SALE	16.01	2K	32.02K	527.98K
Mar 29, 2023	HARRIS TODD	SALE	16.18	1.42K	22.98K	1.7M
Mar 29, 2023	BENSEN DANIEL	SALE	16.21	2.19K	35.46K	527.98K
Mar 28, 2023	BENSEN DANIEL	SALE	16.00	3.35K	53.54K	527.98K
Mar 28, 2023	HARRIS TODD	SALE	16.00	2.78K	44.46K	1.7M
Mar 23, 2023	BENSEN DANIEL	SALE	16.00	4.83K	77.23K	527.98K
Mar 23, 2023	HARRIS TODD	SALE	16.00	2.8K	44.8K	1.7M
Feb 10, 2023	MVA INVESTORS, LLC	SALE	13.40	65.57K	878.61K	22.53K
Feb 09, 2023	MVA INVESTORS, LLC	SALE	13.10	200K	2.62M	88.1K
Dec 17, 2021	BOXER CAPITAL, LLC	PURCHASE	13.12	125K	1.64M	6.45M
Sep 17, 2021	MORE ROBERT J	PURCHASE	16.00	156.25K	2.5M	4.08M
Sep 17, 2021	ALTA PARTNERS NEXTGEN FUND II MANAGEMENT, LLC	PURCHASE	16.00	156.25K	2.5M	4.08M
Sep 17, 2021	BOXER CAPITAL, LLC	PURCHASE	16.00	625K	10M	6.32M
Sep 17, 2021	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	16.00	1.25M	20M	5.3M
Sep 17, 2021	CORMORANT ASSET MANAGEMENT, LP	PURCHASE	16.00	312.5K	5M	1.07M

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES510.19K10

NET SHARES-510.19K10

SHARES HELD9.55M10

% NET SHARES-105.34%0%

Frequently Asked Questions