How many institutions own TSHA stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own TSHA shares is 211, representing 97.41% of the company's common stock.

Who are the major shareholders selling Taysha Gene Therapies, Inc. stock?

ADAR1 CAPITAL MANAGEMENT, LLC, in the last quarter, reduced its stake in TSHA by -11.99% restricting it's holding to 2.5 million shares of worth nearly $13.73M. MORGAN STANLEY also lessened -6.37% of the TSHA shares from its portfolio, reducing its holding to 18.08 million shares of worth $99.43M. BANK OF AMERICA CORP /DE/ also shunned TSHA shares holding by -11.83% last quarter which brought its holding to 1.15 million shares worth $6.34M.

Investors who are buying TSHA stock?

As per its latest 13F filing, GOLDMAN SACHS GROUP INC increased its stake in TSHA by 2.31% in the last quarter. The institutional holder raised its holding to 13.69 million shares having worth more than $75.31M. BLACKROCK, INC. also added 13.92% more shares of TSHA to its portfolio, raising its holding to 18.64 million shares of worth $102.54M. PRIVIUM FUND MANAGEMENT B.V. also increased its TSHA shares holding by 22.24% which brought its holding to 164.9 thousand shares worth $906.95K.

TSHA's major insiders: who are they?

The insider with the most stakes in TSHA is Session R.A. II , 10 percent owner at the company. Additionally, TSHA stock is highly held by Chief Executive Officer Nolan Sean P. and 10 percent owner Manning Paul B among others.

Did an insider recently sell TSHA stock?

Company executives, directors, and other insiders own 11.04% percent of Taysha Gene Therapies, Inc.'s stock. Within the last six months, there have been 11 transaction(s) in which TSHA insiders have sold stock, totaling 1.17M shares. Insiders that have sold shares include ALAM KAMRAN, NAGENDRAN SUKUMAR, and NOLAN SEAN P..

Which insider recently purchased TSHA stock?

There have been 0 transaction(s) during the past 6-months in which Taysha Gene Therapies, Inc. insiders have bought stock, totalling 0 shares

How much of TSHA does insiders own?

Around 16.9M Taysha Gene Therapies, Inc. shares are held by insiders, which represents about 11.04% of TSHA stock.

Who is the insider with the largest stake?

TSHA 10 percent owner, Session R.A. II holds the largest portfolio of the company's shares. TSHA shares owned by Session total nearly 8.87 million.

Which institution holds the most shares in TSHA?

ADAR1 CAPITAL MANAGEMENT, LLC is the largest institutional owner in TSHA which holds 2.5 million shares worth $13.73M or 0.71% of the total TSHA shares outstanding followed by GOLDMAN SACHS GROUP INC with ownership of 13.69 million shares representing 3.88% of the TSHA ownership. MORGAN STANLEY is the third largest stakeholder with 18.08 million shares or 5.12% of the ownership worth more than $99.43M.

Is Taysha Gene Therapies, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the TSHA is concerned, it is a stock which is optionable.

Is there a short position on TSHA's shares?

Number of TSHA shares short is 40.78M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding TSHA shares are there?

As of today, 272.80M shares of TSHA are outstanding.

Is there many float in TSHA stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, TSHA has 173.43M shares in float.

TSHA short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for TSHA is 15.11.

Taysha Gene Therapies (TSHA) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares14.95

Short Percent Of Float16.7

Shares Outstanding272.80M

Shares Float173.43M

Shares Short40.78M

Short Ratio15.11

16.7%

Short % of Float

14.95%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

11.04% Percentage of Shares held by All Insiders

97.41% Percentage of Shares held by All Institutions

109.5% Percentage of Float held by Institutions

211

Number of Institutions Holding Shares

Institutional Ownership

About 97.41% of TSHA shares are held by financial institutions. ADAR1 CAPITAL MANAGEMENT, LLC is the top corporate investor, holding 2.5M shares valued at $13.73M. A 0.71% stake in Taysha Gene Therapies, Inc. is owned by the company. GOLDMAN SACHS GROUP INC owns 13.69M shares valued at $75.31M, which translates its holding of 3.88% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.71%	2.5M	13.73M	-339.87K	-11.99%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	3.88%	13.69M	75.31M	309.03K	+2.31%
Dec 31, 2025	MORGAN STANLEY	5.12%	18.08M	99.43M	-1.23M	-6.37%
Dec 31, 2025	BLACKROCK, INC.	5.28%	18.64M	102.54M	2.28M	+13.92%
Dec 31, 2025	PRIVIUM FUND MANAGEMENT B.V.	0.05%	164.9K	906.95K	30K	+22.24%
Dec 31, 2025	EAM INVESTORS, LLC	0.23%	823.76K	4.53M	823.76K	+100.00%
Dec 31, 2025	ABRDN PLC	0.29%	1.02M	5.62M	1.02M	+100.00%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	0.33%	1.15M	6.34M	-154.61K	-11.83%
Dec 31, 2025	NORGES BANK	0.52%	1.84M	10.11M	1.84M	+100.00%
Dec 31, 2025	CITADEL ADVISORS LLC	0.53%	1.85M	10.2M	1.49M	+404.98%
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	0.9%	3.18M	17.48M	-847.26K	-21.04%
Dec 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.14%	490.47K	2.7M	145.31K	+42.10%
Dec 31, 2025	CAPTION MANAGEMENT, LLC	0.14%	490.7K	2.7M	490.7K	+100.00%
Dec 31, 2025	ALLY BRIDGE GROUP (NY) LLC	0.14%	500K	2.75M	500K	+100.00%
Dec 31, 2025	WOODLINE PARTNERS LP	0.14%	500K	2.75M	0	0
Dec 31, 2025	NUVEEN, LLC	0.15%	545.29K	3M	38.08K	+7.51%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.18%	624.37K	3.43M	-472	-0.08%
Dec 31, 2025	GRANAHAN INVESTMENT MANAGEMENT, LLC	0.2%	703.97K	3.87M	-412.66K	-36.96%
Dec 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.2%	711.24K	3.91M	143.23K	+25.22%
Dec 31, 2025	SANDS CAPITAL VENTURES, LLC	0.21%	724.87K	3.99M	0	0
Dec 31, 2025	JPMORGAN CHASE & CO	0.22%	774.41K	4.26M	478.17K	+161.41%
Dec 31, 2025	SUPERSTRING CAPITAL MANAGEMENT LP	0.28%	980.77K	5.39M	980.77K	+100.00%
Dec 31, 2025	PALO ALTO INVESTORS LP	0.33%	1.18M	6.51M	-62.84K	-5.04%
Dec 31, 2025	NORTHERN TRUST CORP	0.35%	1.24M	6.81M	-479.19K	-27.91%
Dec 31, 2025	RICE HALL JAMES & ASSOCIATES, LLC	0.36%	1.27M	6.99M	692.53K	+119.79%
Dec 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.38%	1.33M	7.3M	-2M	-60.10%
Dec 31, 2025		0.38%	1.33M	7.32B	1.33M	+100.00%
Dec 31, 2025	INVESCO LTD.	0.38%	1.33M	7.33M	1.05M	+376.35%
Dec 31, 2025	CASDIN CAPITAL, LLC	0.42%	1.5M	8.25M	1.5M	+100.00%
Dec 31, 2025	B GROUP, INC.	0.51%	1.8M	9.9M	0	0
Dec 31, 2025	VANGUARD GROUP INC	3.76%	13.27M	72.97M	418.19K	+3.25%
Dec 31, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.77%	2.72M	14.97M	-2.66M	-49.46%
Dec 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	1.1%	3.87M	21.28M	-3.46M	-47.23%
Dec 31, 2025	BAKER BROS. ADVISORS LP	1.13%	4M	22.03M	0	0
Dec 31, 2025	D. E. SHAW & CO., INC.	1.14%	4.01M	22.07M	1.31M	+48.30%
Dec 31, 2025	POLAR CAPITAL HOLDINGS PLC	2.24%	7.93M	43.62M	2.64M	+49.82%
Dec 31, 2025	OCTAGON CAPITAL ADVISORS LP	2.51%	8.86M	48.73M	-207.59K	-2.29%
Dec 31, 2025	FMR LLC	3.83%	13.53M	74.41M	-1.07M	-7.30%
Dec 31, 2025	VESTAL POINT CAPITAL, LP	3.89%	13.75M	75.63M	8.25M	+150.00%
Dec 31, 2025	RTW INVESTMENTS, LP	4.64%	16.4M	90.19M	-7.96M	-32.67%
Dec 31, 2025	AVORO CAPITAL ADVISORS LLC	6.14%	21.7M	119.35M	0	0
Dec 31, 2025	RA CAPITAL MANAGEMENT, L.P.	6.67%	23.56M	129.56M	0	0
Dec 31, 2025	CHICAGO PARTNERS INVESTMENT GROUP LLC	0.05%	166.54K	776.08K	2.5K	+1.53%
Dec 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.05%	167.5K	921.25K	167.5K	+100.00%
Dec 31, 2025	AQR CAPITAL MANAGEMENT LLC	0.05%	168.86K	928.74K	17.86K	+11.83%
Dec 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.05%	171.1K	941.05K	171.1K	+100.00%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.05%	172.48K	948.65K	126.45K	+274.68%
Dec 31, 2025	PALUMBO WEALTH MANAGEMENT LLC	0.05%	178.01K	979.04K	20.65K	+13.13%
Dec 31, 2025	WEXFORD CAPITAL LP	0.05%	180.85K	994.69K	177.35K	+5,067.23%
Dec 31, 2025	VICTORY CAPITAL MANAGEMENT INC	0.06%	195.76K	1.08M	170.16K	+664.70%
Dec 31, 2025	GSA CAPITAL PARTNERS LLP	0.06%	208.02K	1.14M	-269.73K	-56.46%
Dec 31, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.06%	218.19K	1.2M	181.69K	+497.77%
Dec 31, 2025	ALPS ADVISORS INC	0.06%	224.92K	1.24M	224.92K	+100.00%
Dec 31, 2025	RHUMBLINE ADVISERS	0.07%	257.44K	1.42B	-31.42K	-10.88%
Dec 31, 2025	NOMURA HOLDINGS INC	0.07%	259.34K	1.43M	259.34K	+100.00%
Dec 31, 2025	ORACLE INVESTMENT MANAGEMENT INC	0.08%	265K	1.46M	265K	+100.00%
Dec 31, 2025	SWISS NATIONAL BANK	0.08%	268.8K	1.48M	268.8K	+100.00%
Dec 31, 2025	ENSIGN PEAK ADVISORS, INC	0.08%	275.11K	1.51M	275.11K	+100.00%
Dec 31, 2025	AMERICAN CENTURY COMPANIES INC	0.08%	288.54K	1.59M	249.98K	+648.35%
Dec 31, 2025	COLONY GROUP, LLC	0.08%	295.52K	1.63M	295.52K	+100.00%
Dec 31, 2025	CAPRICORN FUND MANAGERS LTD	0.08%	300K	1.65M	300K	+100.00%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.09%	305.09K	1.68M	159.99K	+110.26%
Dec 31, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.09%	308.46K	1.7M	308.46K	+100.00%
Dec 31, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.1%	344.78K	1.9M	105K	+43.79%
Dec 31, 2025	TWO SIGMA INVESTMENTS, LP	0.1%	351.13K	1.93M	285.02K	+431.16%
Dec 31, 2025	UBS GROUP AG	0.11%	383.04K	2.11M	-256.31K	-40.09%
Dec 31, 2025	HRT FINANCIAL LP	0.12%	409.25K	2.25M	409.25K	+100.00%
Dec 31, 2025	SQUAREPOINT OPS LLC	0.13%	471.58K	2.59M	273.23K	+137.75%
Dec 31, 2025	SG AMERICAS SECURITIES, LLC	0.22%	781.47K	4.3M	748.53K	+2,271.77%
Dec 31, 2025	QUANTUM PRIVATE WEALTH, LLC	0.23%	819.72K	4.51M	-2.36K	-0.29%
Dec 31, 2025	PROFUND ADVISORS LLC	0.04%	128.59K	707.25K	75.22K	+140.96%
Dec 31, 2025	LEGAL & GENERAL GROUP PLC	0.04%	133.15K	732.3K	110K	+475.17%
Dec 31, 2025	POLEN CAPITAL MANAGEMENT LLC	0.04%	156.59K	861.22K	156.59K	+100.00%
Dec 31, 2025	DEUTSCHE BANK AG\	0.05%	160.78K	884.29K	37.98K	+30.93%
Dec 31, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	113.27K	622.96K	-13.78K	-10.85%
Dec 31, 2025	JANE STREET GROUP, LLC	0.05%	163.15K	897.3K	-393.64K	-70.70%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.54%	1.9M	10.47M	56.47K	+3.06%
Dec 31, 2025	AFFINITY ASSET ADVISORS, LLC	0.93%	3.3M	18.15M	300K	+10.00%
Dec 31, 2025	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	1.05%	3.72M	20.47M	3.72M	+100.00%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.52%	5.39M	29.63M	212.51K	+4.11%
Dec 31, 2025	BARCLAYS PLC	1.57%	5.54M	30.46M	390.89K	+7.59%
Dec 31, 2025	SIREN, L.L.C.	2.87%	10.13M	55.71M	-884.82K	-8.03%
Dec 31, 2025	STATE STREET CORP	3.05%	10.79M	59.35M	3.55M	+49.11%
Sep 30, 2025	CITIGROUP INC	0.01%	33.5K	109.53K	-96.82K	-74.30%
Sep 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.01%	36.5K	119.36K	-10.67K	-22.62%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.01%	38.56K	126.08K	38.56K	+100.00%
Sep 30, 2025	WILLIAMS & NOVAK, LLC	0.02%	45K	147.15K	0	0
Sep 30, 2025	WOODLINE PARTNERS LP	0.17%	500K	1.64M	-500.25K	-50.01%
Sep 30, 2025	NUVEEN, LLC	0.17%	507.21K	1.66M	42.07K	+9.04%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.02%	46.03K	150.53K	27.44K	+147.61%
Sep 30, 2025	PROSHARE ADVISORS LLC	0.02%	46.04K	150.55K	2.29K	+5.24%
Sep 30, 2025	QUADRATURE CAPITAL LTD	0.02%	47.33K	154.29K	-114.61K	-70.77%
Sep 30, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	47.82K	156.36K	-4.71K	-8.97%
Sep 30, 2025	AXQ CAPITAL, LP	0.02%	49.68K	162.44K	-7.32K	-12.85%
Sep 30, 2025	PROFUND ADVISORS LLC	0.02%	53.37K	174.51K	26.77K	+100.63%
Sep 30, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.02%	57.17K	186.94K	11.49K	+25.15%
Sep 30, 2025	COMMONWEALTH EQUITY SERVICES, LLC	0.02%	58.26K	191K	-1.78K	-2.96%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.02%	67.6K	221.05K	46.5K	+220.38%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.02%	68.63K	224.41K	-13.57K	-16.51%
Sep 30, 2025	MITSUBISHI UFJ KOKUSAI ASSET MANAGEMENT CO., LTD.	0.03%	80.73K	263.99K	161	+0.20%
Sep 30, 2025	FRANKLIN RESOURCES INC	0.04%	108.4K	354.46K	0	0
Sep 30, 2025	DEUTSCHE BANK AG\	0.04%	122.8K	401.55K	15.08K	+14.00%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	127.04K	415.43K	18.97K	+17.55%
Sep 30, 2025	PRIVIUM FUND MANAGEMENT B.V.	0.05%	134.9K	441.12K	0	0
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.05%	145.1K	474.47K	37.86K	+35.31%
Sep 30, 2025	PALUMBO WEALTH MANAGEMENT LLC	0.05%	157.35K	514.55K	157.35K	+100.00%
Sep 30, 2025	READYSTATE ASSET MANAGEMENT LP	0.05%	161.97K	529.65K	161.97K	+100.00%
Sep 30, 2025	CHICAGO PARTNERS INVESTMENT GROUP LLC	0.06%	164.04K	818.55K	271	+0.17%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.08%	239.79K	784.1K	121.1K	+102.04%
Sep 30, 2025	INVESCO LTD.	0.09%	279.79K	914.92K	76.12K	+37.38%
Sep 30, 2025	RHUMBLINE ADVISERS	0.1%	288.86K	944.56K	55.6K	+23.84%
Sep 30, 2025	JPMORGAN CHASE & CO	0.1%	296.24K	968.72K	73.6K	+33.05%
Sep 30, 2025	KOVITZ INVESTMENT GROUP PARTNERS, LLC	0.1%	298.67K	976.64K	0	0
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.12%	345.16K	1.13M	345.16K	+100.00%
Sep 30, 2025	UBS GROUP AG	0.21%	639.36K	2.09M	378.12K	+144.74%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.19%	568.01K	1.86M	-67.96K	-10.69%
Sep 30, 2025	ROYAL BANK OF CANADA	0.2%	583.38K	1.91M	88.06K	+17.78%
Sep 30, 2025	QUANTUM PRIVATE WEALTH, LLC	0.28%	822.08K	2.69M	6.1K	+0.75%
Sep 30, 2025	STEMPOINT CAPITAL LP	0.28%	839.67K	2.75M	-364.27K	-30.26%
Sep 30, 2025	TANG CAPITAL MANAGEMENT LLC	0.3%	900K	2.94M	0	0
Sep 30, 2025	NORTHERN TRUST CORP	0.58%	1.72M	5.62M	388.44K	+29.23%
Sep 30, 2025	GREAT POINT PARTNERS LLC	0.5%	1.5M	4.91M	0	0
Sep 30, 2025	B GROUP, INC.	0.6%	1.8M	5.89M	0	0
Sep 30, 2025	GRANAHAN INVESTMENT MANAGEMENT, LLC	0.37%	1.12M	3.65M	158.14K	+16.50%
Sep 30, 2025	PALO ALTO INVESTORS LP	0.42%	1.25M	4.07M	0	0
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.44%	1.31M	4.27M	576.56K	+78.90%
Sep 30, 2025	JANE STREET GROUP, LLC	0.19%	556.79K	1.82M	419.79K	+306.43%
Sep 30, 2025	SPHERA FUNDS MANAGEMENT LTD.	0.14%	408.15K	1.33M	-11.85K	-2.82%
Sep 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.14%	415.61K	1.36M	415.61K	+100.00%
Sep 30, 2025	ACUTA CAPITAL PARTNERS, LLC	0.15%	454.83K	1.49M	-30.84K	-6.35%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.21%	624.84K	2.04M	166.18K	+36.23%
Sep 30, 2025	ALPHABET INC.	0.22%	640.88K	2.1M	0	0
Sep 30, 2025	ANSON FUNDS MANAGEMENT LP	0.2%	603.5K	1.97M	-200K	-24.89%
Sep 30, 2025	MARSHALL WACE, LLP	0.16%	476.87K	1.56M	397.37K	+499.85%
Sep 30, 2025	GSA CAPITAL PARTNERS LLP	0.16%	477.75K	1.56M	433.06K	+969.03%
Sep 30, 2025	SANDS CAPITAL VENTURES, LLC	0.24%	724.87K	2.37M	0	0
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.62%	1.85M	6.04M	1.35M	+275.53%
Sep 30, 2025	ALLY BRIDGE GROUP (NY) LLC	0.64%	1.9M	6.21M	1.9M	+100.00%
Sep 30, 2025	TORONTO DOMINION BANK	0.65%	1.92M	6.29M	-2.8M	-59.31%
Sep 30, 2025	JEFFERIES FINANCIAL GROUP INC.	0.72%	2.16M	7.05M	-8.16M	-79.09%
Sep 30, 2025	D. E. SHAW & CO., INC.	0.91%	2.71M	8.85M	2.3M	+574.07%
Sep 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.95%	2.84M	9.27M	-174.19K	-5.79%
Sep 30, 2025	AFFINITY ASSET ADVISORS, LLC	1.01%	3M	9.81M	2.8M	+1,400.00%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.12%	3.33M	10.88M	-1.51M	-31.23%
Sep 30, 2025	TYBOURNE CAPITAL MANAGEMENT (HK) LTD	1.24%	3.7M	12.1M	-395K	-9.65%
Sep 30, 2025	BAKER BROS. ADVISORS LP	1.34%	4M	13.1M	0	0
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	1.35%	4.03M	13.17M	1.09M	+37.14%
Sep 30, 2025	BARCLAYS PLC	1.73%	5.15M	16.83M	4.7M	+1,042.75%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.74%	5.17M	16.92M	1.38M	+36.40%
Sep 30, 2025	POLAR CAPITAL HOLDINGS PLC	1.78%	5.29M	17.31M	293.88K	+5.88%
Sep 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.81%	5.39M	17.61M	0	0
Sep 30, 2025	VESTAL POINT CAPITAL, LP	1.85%	5.5M	17.99M	2.5M	+83.33%
Sep 30, 2025	STATE STREET CORP	2.43%	7.24M	23.66M	2.1M	+40.83%
Sep 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	2.46%	7.33M	23.97M	13.86K	+0.19%
Sep 30, 2025	OCTAGON CAPITAL ADVISORS LP	3.04%	9.07M	29.65M	-3.53M	-27.99%
Sep 30, 2025	SIREN, L.L.C.	3.7%	11.01M	36.02M	0	0
Sep 30, 2025	VANGUARD GROUP INC	4.31%	12.85M	42.02M	1.96M	+17.95%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	4.49%	13.38M	43.76M	796.01K	+6.32%
Sep 30, 2025	FMR LLC	4.9%	14.59M	47.72M	-1.03M	-6.62%
Sep 30, 2025	BLACKROCK, INC.	5.49%	16.36M	53.51M	3.06M	+23.01%
Sep 30, 2025	MORGAN STANLEY	6.48%	19.31M	63.14M	2.44M	+14.48%
Sep 30, 2025	AVORO CAPITAL ADVISORS LLC	7.28%	21.7M	70.96M	0	0
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	7.9%	23.56M	77.03M	0	0
Sep 30, 2025	RTW INVESTMENTS, LP	8.17%	24.35M	79.64M	-667.29K	-2.67%
Sep 30, 2025	RICE HALL JAMES & ASSOCIATES, LLC	0.19%	578.12K	1.89M	578.12K	+100.00%
Sep 30, 2025		0.01%	29.48K	96.39K	29.48K	+100.00%
Sep 30, 2025	SG AMERICAS SECURITIES, LLC	0.01%	32.95K	108K	-460.35K	-93.32%
Jun 30, 2025	ACUTA CAPITAL PARTNERS, LLC	0.16%	485.67K	1.12M	485.67K	+100.00%
Jun 30, 2025	STEMPOINT CAPITAL LP	0.4%	1.2M	2.78M	1.2M	+100.00%
Jun 30, 2025	CHICAGO PARTNERS INVESTMENT GROUP LLC	0.06%	163.77K	440.53K	47.2K	+40.49%
Jun 30, 2025	QUADRATURE CAPITAL LTD	0.05%	161.94K	373.27K	161.94K	+100.00%
Jun 30, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.05%	148.36K	343K	148.36K	+100.00%
Jun 30, 2025	PRIVIUM FUND MANAGEMENT B.V.	0.05%	134.9K	315.67K	0	0
Jun 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.04%	118.68K	274.16K	118.68K	+100.00%
Jun 30, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.04%	117.74K	271.98K	-25.07K	-17.55%
Jun 30, 2025	OMERS ADMINISTRATION CORP	0.02%	72.9K	168.4K	72.9K	+100.00%
Jun 30, 2025	ENTRYPOINT CAPITAL, LLC	0.02%	69.11K	159.64K	-66.79K	-49.15%
Jun 30, 2025	MILITIA CAPITAL PARTNERS, LP	0.02%	66.8K	154.31K	66.8K	+100.00%
Jun 30, 2025	ENGINEERS GATE MANAGER LP	0.02%	64.62K	149.27K	64.62K	+100.00%
Jun 30, 2025	COMMONWEALTH EQUITY SERVICES, LLC	0.02%	60.04K	139K	-33	-0.05%
Jun 30, 2025	RTW INVESTMENTS, LP	8.4%	25.02M	57.8M	6.23M	+33.18%
Jun 30, 2025	OCTAGON CAPITAL ADVISORS LP	4.23%	12.59M	29.09M	1.89M	+17.69%
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	2.46%	7.32M	16.9M	2.75M	+60.13%
Jun 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.81%	5.39M	12.44M	5.39M	+100.00%
Jun 30, 2025	POLAR CAPITAL HOLDINGS PLC	1.68%	5M	11.55M	2M	+66.67%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.62%	4.84M	11.18M	4.84M	+100.00%
Jun 30, 2025	TYBOURNE CAPITAL MANAGEMENT (HK) LTD	1.37%	4.1M	9.46M	395K	+10.68%
Jun 30, 2025	BAKER BROS. ADVISORS LP	1.34%	4M	9.25M	0	0
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.27%	3.79M	8.77M	128.84K	+3.52%
Jun 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	1.01%	3.01M	6.95M	1.94M	+182.27%
Jun 30, 2025	VESTAL POINT CAPITAL, LP	1.01%	3M	6.93M	3M	+100.00%
Jun 30, 2025	BIOIMPACT CAPITAL LLC	0.99%	2.95M	6.82M	2.95M	+100.00%
Jun 30, 2025	NORTHERN TRUST CORP	0.45%	1.33M	3.07M	-102.93K	-7.19%
Jun 30, 2025	GRANAHAN INVESTMENT MANAGEMENT, LLC	0.32%	958.49K	2.21M	-682.3K	-41.58%
Jun 30, 2025	TANG CAPITAL MANAGEMENT LLC	0.3%	900K	2.08M	900K	+100.00%
Jun 30, 2025	QUANTUM PRIVATE WEALTH, LLC	0.27%	815.98K	1.88M	24.5K	+3.10%
Jun 30, 2025	ANSON FUNDS MANAGEMENT LP	0.27%	803.5K	1.86M	803.5K	+100.00%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.25%	730.73K	1.69M	93.89K	+14.74%
Jun 30, 2025	ALPHABET INC.	0.22%	640.88K	1.48M	0	0
Jun 30, 2025	BARCLAYS PLC	0.15%	450.5K	1.04M	-258.47K	-36.46%
Jun 30, 2025	SPHERA FUNDS MANAGEMENT LTD.	0.14%	420K	970.2K	420K	+100.00%
Jun 30, 2025	XTX TOPCO LTD	0.11%	320.74K	740.9K	117.61K	+57.90%
Jun 30, 2025	KOVITZ INVESTMENT GROUP PARTNERS, LLC	0.1%	298.67K	689.92K	5.89K	+2.01%
Jun 30, 2025	UBS GROUP AG	0.09%	261.24K	603.46K	-156.89K	-37.52%
Jun 30, 2025	RHUMBLINE ADVISERS	0.08%	233.26K	538.81K	27.79K	+13.53%
Jun 30, 2025	JPMORGAN CHASE & CO	0.07%	222.65K	514.32K	-780.42K	-77.80%
Jun 30, 2025	WILLIAMS & NOVAK, LLC	0.02%	45K	103.95K	0	0
Jun 30, 2025	VIRTUS INVESTMENT ADVISERS, INC.	0.01%	35.48K	81.97K	-37.47K	-51.36%
Jun 30, 2025	FIRST MANHATTAN CO. LLC.	0.01%	28.5K	65.84K	0	0
Jun 30, 2025	ETHIC INC.	0.01%	27.98K	66.58K	27.98K	+100.00%
Jun 30, 2025	POINT72 ASIA (SINGAPORE) PTE. LTD.	0.01%	25.25K	58.33K	25.25K	+100.00%
Jun 30, 2025	DAIWA SECURITIES GROUP INC.	0.01%	23.84K	55K	23.15K	+3,350.22%
Jun 30, 2025	CIBC WORLD MARKETS CORP	0.01%	20.42K	47.16K	-18.48K	-47.51%
Jun 30, 2025	LEE FINANCIAL CO	0.01%	20K	46.2K	0	0
Jun 30, 2025	HOWARD CAPITAL MANAGEMENT INC.	0%	14.17K	32.72K	0	0
Jun 30, 2025	XPONANCE, INC.	0%	12.84K	29.65K	198	+1.57%
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	7.9%	23.56M	54.41M	12.68M	+116.65%
Jun 30, 2025	AVORO CAPITAL ADVISORS LLC	7.28%	21.7M	50.13M	1.7M	+8.50%
Jun 30, 2025	MORGAN STANLEY	5.66%	16.87M	38.96B	18.71K	+0.11%
Jun 30, 2025	FMR LLC	5.24%	15.63M	36.1M	-4.13K	-0.03%
Jun 30, 2025	BLACKROCK, INC.	4.46%	13.3M	30.73M	-285.4K	-2.10%
Jun 30, 2025	SIREN, L.L.C.	3.7%	11.01M	25.44M	4.5M	+69.07%
Jun 30, 2025	SUVRETTA CAPITAL MANAGEMENT, LLC	1.08%	3.22M	7.43M	3.22M	+100.00%
Jun 30, 2025	GREAT POINT PARTNERS LLC	0.5%	1.5M	3.47M	1.5M	+100.00%
Jun 30, 2025	PALO ALTO INVESTORS LP	0.42%	1.25M	2.88M	-173.44K	-12.22%
Jun 30, 2025	AFFINITY ASSET ADVISORS, LLC	0.07%	200K	462K	200K	+100.00%
Jun 30, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0.03%	96.54K	223.42K	-6.53K	-6.34%
Jun 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	82.2K	189.87K	-17.72K	-17.73%
Jun 30, 2025	MITSUBISHI UFJ KOKUSAI ASSET MANAGEMENT CO., LTD.	0.03%	80.57K	186.12K	80.57K	+100.00%
Jun 30, 2025	MARSHALL WACE, LLP	0.03%	79.5K	183.64K	79.5K	+100.00%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.99%	2.94M	6.78M	1.16M	+65.61%
Jun 30, 2025	TORONTO DOMINION BANK	1.59%	4.73M	10.92M	4.73M	+100.00%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.06%	179.62K	414.92M	71.37K	+65.93%
Jun 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.05%	135.77K	313.62M	27.87K	+25.83%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	4.22%	12.59M	29.08B	12.23M	+3,406.25%
Jun 30, 2025	VANGUARD GROUP INC	3.66%	10.89M	25.17M	2.12M	+24.21%
Jun 30, 2025	CITADEL ADVISORS LLC	0.18%	528.99K	1.22B	312.38K	+144.21%
Jun 30, 2025	D. E. SHAW & CO., INC.	0.13%	401.51K	927.49M	401.51K	+100.00%
Jun 30, 2025	JEFFERIES FINANCIAL GROUP INC.	3.46%	10.31M	23.82M	10.07M	+4,105.33%
Jun 30, 2025	STATE STREET CORP	1.72%	5.14M	11.87M	1.9M	+58.91%
Jun 30, 2025	WOODLINE PARTNERS LP	0.34%	1M	2.31M	142K	+16.55%
Jun 30, 2025	SANDS CAPITAL VENTURES, LLC	0.24%	724.87K	1.67M	0	0
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.21%	635.97K	1.47M	10.77K	+1.72%
Jun 30, 2025	ROYAL BANK OF CANADA	0.17%	495.31K	1.15M	493.85K	+33,779.00%
Jun 30, 2025	SG AMERICAS SECURITIES, LLC	0.17%	493.3K	1.14M	493.3K	+100.00%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.17%	491.71K	1.14M	-55.42K	-10.13%
Jun 30, 2025		0.16%	465.14K	1.07M	-81.27K	-14.87%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.15%	458.66K	1.06M	5.24K	+1.16%
Jun 30, 2025	B GROUP, INC.	0.6%	1.8M	4.16M	545K	+43.41%
Jun 30, 2025	NUVEEN, LLC	0.16%	465.14K	1.07M	-81.27K	-14.87%
Mar 31, 2025	BAKER BROS. ADVISORS LP	1.6%	4M	5.57M	0	0
Mar 31, 2025		0.04%	117.06K	162.72K	117.06K	+100.00%
Mar 31, 2025	QUANTUM PRIVATE WEALTH, LLC	0.29%	791.48K	1.1M	-3.5K	-0.44%
Mar 31, 2025	WOODLINE PARTNERS LP	0.32%	858.25K	1.19M	-169.27K	-16.47%
Mar 31, 2025	CITIGROUP INC	0.05%	133.19K	185.14K	-120.1K	-47.41%
Mar 31, 2025	PRIVIUM FUND MANAGEMENT B.V.	0.05%	134.9K	187.51K	0	0
Mar 31, 2025	RHUMBLINE ADVISERS	0.08%	205.46K	285.58K	13.38K	+6.97%
Mar 31, 2025	CITADEL ADVISORS LLC	0.08%	216.61K	301.09K	-528.59K	-70.93%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.08%	227.47K	316.19K	85.01K	+59.67%
Mar 31, 2025	JEFFERIES FINANCIAL GROUP INC.	0.09%	245.25K	340.9K	245.25K	+100.00%
Mar 31, 2025	SANDS CAPITAL VENTURES, LLC	0.27%	724.87K	1.01M	0	0
Mar 31, 2025	TYBOURNE CAPITAL MANAGEMENT (HK) LTD	1.37%	3.7M	5.14M	0	0
Mar 31, 2025	ENTRYPOINT CAPITAL, LLC	0.05%	135.9K	188.9K	74.4K	+120.99%
Mar 31, 2025	HRT FINANCIAL LP	0.05%	139.69K	194K	139.69K	+100.00%
Mar 31, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.05%	142.81K	198.51K	5.35K	+3.89%
Mar 31, 2025	INVESCO LTD.	0.06%	159.9K	222.26K	72.54K	+83.05%
Mar 31, 2025	XTX TOPCO LTD	0.08%	203.13K	282.35K	203.13K	+100.00%
Mar 31, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.21%	522.5K	726.28K	0	0
Mar 31, 2025	SUPERSTRING CAPITAL MANAGEMENT LP	0.28%	755.6K	1.05M	755.6K	+100.00%
Mar 31, 2025	JPMORGAN CHASE & CO	0.37%	1M	1.39M	-1.64M	-62.06%
Mar 31, 2025	STATE STREET CORP	1.2%	3.23M	4.49M	-3.24M	-50.06%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.36%	3.66M	5.1M	92.38K	+2.59%
Mar 31, 2025	MORGAN STANLEY	6.26%	16.85M	23.42M	-793.99K	-4.50%
Mar 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	1.7%	4.57M	6.35M	4.57M	+100.00%
Mar 31, 2025	SIREN, L.L.C.	2.42%	6.51M	9.06M	-87.74K	-1.33%
Mar 31, 2025	VANGUARD GROUP INC	3.26%	8.77M	12.19M	-135.84K	-1.53%
Mar 31, 2025	NORTHERN TRUST CORP	0.53%	1.43M	1.99M	-27.07K	-1.86%
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.43%	1.07M	1.48M	888.6K	+500.04%
Mar 31, 2025	GRANAHAN INVESTMENT MANAGEMENT, LLC	0.66%	1.64M	2.28M	4.41K	+0.27%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.2%	547.13K	760.51K	72.87K	+15.37%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.13%	359.01K	499.02K	-608.14K	-62.88%
Mar 31, 2025	KOVITZ INVESTMENT GROUP PARTNERS, LLC	0.11%	292.78K	406.96K	292.78K	+100.00%
Mar 31, 2025	DEUTSCHE BANK AG\	0.05%	134.42K	186.84K	-16.67K	-11.03%
Mar 31, 2025	PALO ALTO INVESTORS LP	0.57%	1.42M	1.97M	608.2K	+74.97%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.71%	1.77M	2.46M	1.62M	+1,069.19%
Mar 31, 2025	POLAR CAPITAL HOLDINGS PLC	1.11%	3M	4.17M	0	0
Mar 31, 2025	RTW INVESTMENTS, LP	7.51%	18.79M	26.12M	10.12M	+116.63%
Mar 31, 2025	UBS GROUP AG	0.16%	418.13K	581.2K	-3.26K	-0.77%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.17%	453.42K	630.25K	3.16K	+0.70%
Mar 31, 2025	AVORO CAPITAL ADVISORS LLC	8%	20M	27.8M	0	0
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.23%	625.2K	869.03K	39.6K	+6.76%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.24%	636.84K	885.21K	-1.07M	-62.76%
Mar 31, 2025	ALPHABET INC.	0.24%	640.88K	890.83K	0	0
Mar 31, 2025	BARCLAYS PLC	0.26%	708.97K	985K	373.73K	+111.48%
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	4.35%	10.87M	15.11M	0	0
Mar 31, 2025	OCTAGON CAPITAL ADVISORS LP	3.97%	10.7M	14.87M	250K	+2.39%
Mar 31, 2025	BLACKROCK, INC.	5.05%	13.59M	18.89M	57.71K	+0.43%
Mar 31, 2025	FMR LLC	5.8%	15.63M	21.73M	-733.71K	-4.48%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	2.7%	3.14M	9M	-245.22K	-7.25%
Mar 31, 2024	BREVAN HOWARD CAPITAL MANAGEMENT LP	0.15%	172.77K	495.85K	172.77K	+100.00%
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.15%	175.6K	503.97K	0	0
Mar 31, 2024	POINT72 ASIA (SINGAPORE) PTE. LTD.	0.16%	181.31K	520.35K	181.31K	+100.00%
Mar 31, 2024	BALYASNY ASSET MANAGEMENT L.P.	0.16%	188.7K	541.56K	188.7K	+100.00%
Mar 31, 2024	UBS GROUP AG	0.16%	189.28K	543.25K	185.34K	+4,700.51%
Mar 31, 2024	NORTHERN TRUST CORP	0.18%	211.4K	606.7K	-2.33K	-1.09%
Mar 31, 2024	SQUAREPOINT OPS LLC	0.18%	213.95K	614.03K	150.47K	+237.04%
Mar 31, 2024	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.19%	220K	631.4K	-200K	-47.62%
Mar 31, 2024	MARATHON TRADING INVESTMENT MANAGEMENT LLC	0.19%	223.9K	642.59K	223.9K	+100.00%
Mar 31, 2024	KOVITZ INVESTMENT GROUP PARTNERS, LLC	0.24%	277.78K	797.22K	0	0
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.28%	328.5K	943K	-768.9K	-70.07%
Mar 31, 2024	STATE STREET CORP	0.29%	339.52K	974.42K	196.3K	+137.06%
Mar 31, 2024	HRT FINANCIAL LP	0.36%	414.98K	1.19M	414.98K	+100.00%
Mar 31, 2024	SCHONFELD STRATEGIC ADVISORS LLC	0.48%	552.6K	1.59M	-566.78K	-50.63%
Mar 31, 2024	QUANTUM PRIVATE WEALTH, LLC	0.6%	698.52K	2M	59K	+9.23%
Mar 31, 2024	SANDS CAPITAL VENTURES, LLC	0.62%	724.87K	2.08M	0	0
Mar 31, 2024	GHOST TREE CAPITAL, LLC	0.82%	950K	2.73M	-1.15M	-54.76%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	0.88%	1.02M	2.93M	34.37K	+3.49%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.92%	1.07M	3.08M	953.55K	+804.54%
Mar 31, 2024	STEMPOINT CAPITAL LP	0.94%	1.09M	3.12M	1.09M	+100.00%
Mar 31, 2024	PRICE T ROWE ASSOCIATES INC /MD/	0.95%	1.1M	3.16M	-128K	-10.43%
Mar 31, 2024	POINT72 ASSET MANAGEMENT, L.P.	0.96%	1.11M	3.19M	-1.57M	-58.59%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	1.13%	1.31M	3.76M	-118.52K	-8.30%
Mar 31, 2024	COWEN AND COMPANY, LLC	1.33%	1.55M	4.45M	1.55M	+100.00%
Mar 31, 2024	EAGLE ASSET MANAGEMENT INC	1.54%	1.79M	5.08M	1.79M	+100.00%
Mar 31, 2024	EVERSEPT PARTNERS, LP	2%	2.33M	6.67M	-1.46M	-38.49%
Mar 31, 2024	POLAR CAPITAL HOLDINGS PLC	2.17%	2.52M	7.23M	0	0
Mar 31, 2024	BLACKROCK INC.	2.24%	2.6M	7.45M	-101.94K	-3.78%
Mar 31, 2024	OCTAGON CAPITAL ADVISORS LP	2.61%	3.03M	8.7M	3.03M	+100.00%
Mar 31, 2024	LAURION CAPITAL MANAGEMENT LP	0.14%	164.26K	471.42K	164.26K	+100.00%
Mar 31, 2024	ACUTA CAPITAL PARTNERS, LLC	2.87%	3.33M	9.57M	-256K	-7.13%
Mar 31, 2024	ARTAL GROUP S.A.	3.18%	3.69M	10.58M	24.44K	+0.67%
Mar 31, 2024	TYBOURNE CAPITAL MANAGEMENT (HK) LTD	3.19%	3.7M	10.62M	0	0
Mar 31, 2024	MORGAN STANLEY	4.45%	5.17M	14.83M	4.95M	+2,287.06%
Mar 31, 2024	RA CAPITAL MANAGEMENT, L.P.	9.36%	10.87M	31.2M	-7.6M	-41.14%
Mar 31, 2024	US BANCORP \DE\	0.02%	17.64K	50.62K	17.64K	+100.00%
Mar 31, 2024	DRW SECURITIES, LLC	0.02%	17.8K	51.09K	17.8K	+100.00%
Mar 31, 2024	PRUDENTIAL FINANCIAL INC	0.02%	19.05K	54.67K	0	0
Mar 31, 2024	CANNON GLOBAL INVESTMENT MANAGEMENT, LLC	0.02%	24.2K	69.45K	24.2K	+100.00%
Mar 31, 2024	ACADIAN ASSET MANAGEMENT LLC	0.02%	26.48K	75K	-433.59K	-94.25%
Mar 31, 2024	COMMONWEALTH EQUITY SERVICES, LLC	0.02%	27.27K	78K	27.27K	+100.00%
Mar 31, 2024	POLYMER CAPITAL MANAGEMENT (HK) LTD	0.02%	27.68K	79.44K	27.68K	+100.00%
Mar 31, 2024	OMERS ADMINISTRATION CORP	0.02%	28K	80.36K	28K	+100.00%
Mar 31, 2024	CTC ALTERNATIVE STRATEGIES, LTD.	0.03%	29.8K	85.53K	29.8K	+100.00%
Mar 31, 2024	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.03%	35.91K	103K	14.29K	+66.07%
Mar 31, 2024	XTX TOPCO LTD	0.04%	41.05K	117.82K	24.77K	+152.08%
Mar 31, 2024	LPL FINANCIAL LLC	0.04%	42.06K	120.72K	-16K	-27.55%
Mar 31, 2024	WILLIAMS & NOVAK, LLC	0.04%	45K	79.65K	0	0
Mar 31, 2024	DYNAMIC ADVISOR SOLUTIONS LLC	0.04%	45K	129.15K	0	0
Mar 31, 2024	JEFFERIES FINANCIAL GROUP INC.	0.04%	48.1K	138.05K	48.1K	+100.00%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.04%	51.46K	147.7K	35.32K	+218.85%
Mar 31, 2024	JUMP FINANCIAL, LLC	0.05%	54.09K	155.24K	54.09K	+100.00%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.05%	63.73K	182.89K	2.18K	+3.54%
Mar 31, 2024	OLD MISSION CAPITAL LLC	0.07%	76.42K	219.32K	76.42K	+100.00%
Mar 31, 2024	JPMORGAN CHASE & CO	0.08%	93.74K	269.04K	57.26K	+156.94%
Mar 31, 2024	Y-INTERCEPT (HONG KONG) LTD	0.08%	97.05K	278.55K	97.05K	+100.00%
Mar 31, 2024	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.1%	112.08K	322K	112.08K	+100.00%
Mar 31, 2024	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.1%	112.41K	322.63K	77.01K	+217.55%
Mar 31, 2024	ENTRYPOINT CAPITAL, LLC	0.11%	122.91K	352.74K	-168.71K	-57.85%
Mar 31, 2024	CHICAGO PARTNERS INVESTMENT GROUP LLC	0.11%	125.28K	316.97K	-9.57K	-7.09%
Mar 31, 2024	ALPHABET INC.	0.55%	640.88K	1.84M	0	0
Mar 31, 2024	MARSHALL WACE, LLP	0.89%	1.03M	2.96M	1.03M	+100.00%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.91%	1.06M	3.04M	975.49K	+1,168.61%
Mar 31, 2024	BAKER BROS. ADVISORS LP	3.45%	4M	11.49M	0	0
Mar 31, 2024	VANGUARD GROUP INC	5.1%	5.92M	16.98M	-278.15K	-4.49%
Mar 31, 2024	FMR LLC	17.32%	20.11M	57.72M	-2.33M	-10.38%
Mar 31, 2024	CITIGROUP INC	0.22%	255.2K	732.43K	-55.76K	-17.93%
Mar 31, 2024	PALO ALTO INVESTORS LP	0.7%	811.27K	2.33M	281.41K	+53.11%
Mar 31, 2024	SOLEUS CAPITAL MANAGEMENT, L.P.	0.8%	925K	2.65M	925K	+100.00%
Mar 31, 2024	VR ADVISER, LLC	7.75%	9M	25.83M	-1.41M	-13.57%
Mar 31, 2024	RTW INVESTMENTS, LP	16.01%	18.59M	53.36M	1.7M	+10.06%
Mar 31, 2024	AVORO CAPITAL ADVISORS LLC	16.06%	18.65M	53.53M	14.29M	+328.19%
Mar 31, 2024	DIAMETRIC CAPITAL, LP	0.13%	153.48K	440.48K	84.61K	+122.85%
Mar 31, 2024	CUBIST SYSTEMATIC STRATEGIES, LLC	0.14%	161.1K	462.36K	112.67K	+232.62%
Dec 31, 2023	LPL FINANCIAL LLC	0.05%	58.06K	102.77K	1.13K	+1.98%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.05%	58.14K	102.91K	32.07K	+122.98%
Dec 31, 2023	SCHONFELD STRATEGIC ADVISORS LLC	0.89%	1.12M	1.98M	399.33K	+55.46%
Dec 31, 2023	PRICE T ROWE ASSOCIATES INC /MD/	0.98%	1.23M	2.17M	-20.14K	-1.61%
Dec 31, 2023	GHOST TREE CAPITAL, LLC	1.67%	2.1M	3.72M	775K	+58.49%
Dec 31, 2023	CITADEL ADVISORS LLC	1.83%	2.3M	4.07M	2.3M	+100.00%
Dec 31, 2023	POLAR CAPITAL HOLDINGS PLC	2%	2.52M	4.46M	-11.09K	-0.44%
Dec 31, 2023	POINT72 ASSET MANAGEMENT, L.P.	2.14%	2.69M	4.76M	1.75M	+187.01%
Dec 31, 2023	BLACKROCK INC.	2.15%	2.7M	4.78M	1.95M	+260.83%
Dec 31, 2023	ACADIAN ASSET MANAGEMENT LLC	0.37%	460.07K	813K	460.07K	+100.00%
Dec 31, 2023	TCG CROSSOVER MANAGEMENT, LLC	2.32%	2.91M	5.16M	-8.2M	-73.78%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	2.69%	3.38M	5.98M	3.38M	+100.00%
Dec 31, 2023	ACUTA CAPITAL PARTNERS, LLC	2.86%	3.59M	6.35M	-238.59K	-6.23%
Dec 31, 2023	ARTAL GROUP S.A.	2.91%	3.66M	6.48M	0	0
Dec 31, 2023	TYBOURNE CAPITAL MANAGEMENT (HK) LTD	2.94%	3.7M	6.55M	2.2M	+146.67%
Dec 31, 2023	EVERSEPT PARTNERS, LP	3.01%	3.78M	6.69M	2.07M	+121.64%
Dec 31, 2023	BAKER BROS. ADVISORS LP	3.19%	4M	7.09M	1.5M	+59.89%
Dec 31, 2023	AVORO CAPITAL ADVISORS LLC	3.47%	4.36M	7.71M	430.56K	+10.97%
Dec 31, 2023	VANGUARD GROUP INC	4.93%	6.2M	10.97M	867.7K	+16.29%
Dec 31, 2023	VR ADVISER, LLC	8.28%	10.41M	18.43M	-4.03M	-27.91%
Dec 31, 2023	RTW INVESTMENTS, LP	13.44%	16.89M	29.9M	0	0
Dec 31, 2023	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.05%	61.55K	108.94K	0	0
Dec 31, 2023	SQUAREPOINT OPS LLC	0.05%	63.48K	112.35K	34.91K	+122.20%
Dec 31, 2023	QUANTUM PRIVATE WEALTH, LLC	0.51%	639.52K	1.13M	64.14K	+11.15%
Dec 31, 2023	RA CAPITAL MANAGEMENT, L.P.	14.7%	18.47M	32.7M	0	0
Dec 31, 2023	FMR LLC	17.85%	22.44M	39.72M	-2.09M	-8.52%
Dec 31, 2023	ALPHABET INC.	0.51%	640.88K	1.13M	0	0
Dec 31, 2023		0.17%	209K	369.93K	209K	+100.00%
Dec 31, 2023	SANDS CAPITAL VENTURES, LLC	0.58%	724.87K	1.28M	0	0
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	0.78%	985.42K	1.74M	523.76K	+113.45%
Dec 31, 2023	RENAISSANCE TECHNOLOGIES LLC	0.87%	1.1M	1.94M	499.4K	+83.51%
Dec 31, 2023	DIAMETRIC CAPITAL, LP	0.05%	68.87K	121.9K	-691.14K	-90.94%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.07%	83.47K	147.75K	83.47K	+100.00%
Dec 31, 2023	QUBE RESEARCH & TECHNOLOGIES LTD	0.09%	118.52K	209.78K	118.52K	+100.00%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.1%	122.33K	216.52K	84.15K	+220.40%
Dec 31, 2023	CHICAGO PARTNERS INVESTMENT GROUP LLC	0.11%	134.85K	198.23K	23.74K	+21.37%
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	0.11%	136.97K	242.44K	136.97K	+100.00%
Dec 31, 2023	STATE STREET CORP	0.11%	143.22K	253.5K	3.2K	+2.29%
Dec 31, 2023	TD ASSET MANAGEMENT INC	0.14%	175.6K	310.81K	0	0
Dec 31, 2023	POLAR ASSET MANAGEMENT PARTNERS INC.	0.15%	186.7K	330.46K	186.7K	+100.00%
Dec 31, 2023	PRELUDE CAPITAL MANAGEMENT, LLC	0.15%	189.88K	336.08K	-50.38K	-20.97%
Dec 31, 2023	PALO ALTO INVESTORS LP	0.42%	529.86K	937.85K	529.86K	+100.00%
Dec 31, 2023	NORTHERN TRUST CORP	0.17%	213.72K	378.29K	147.53K	+222.89%
Dec 31, 2023	MORGAN STANLEY	0.17%	216.54K	383.27K	44.47K	+25.84%
Dec 31, 2023	KOVITZ INVESTMENT GROUP PARTNERS, LLC	0.22%	277.78K	491.67K	252.78K	+1,011.11%
Dec 31, 2023	MONACO ASSET MANAGEMENT SAM	0.23%	295K	522.15K	295K	+100.00%
Dec 31, 2023	CITIGROUP INC	0.25%	310.96K	550.41K	29.84K	+10.62%
Dec 31, 2023	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.33%	420K	743.4K	-1.08M	-72.00%

Insiders

Among the TSHA insiders holding of 11.04% of the stake in company, SESSION R.A. II, 10 percent owner, holds the largest shares of 8.87M. NOLAN SEAN P., Chief Executive Officer, is the second largest TSHA insider with ownership of 2.91M shares. MANNING PAUL B, 10 percent owner, stands third with possession of 2.84M shares of that stake.

Insiders	Designation	Shares Held
SESSION R.A. II	10 percent owner	8.87M
NOLAN SEAN P.	Chief Executive Officer	2.91M
MANNING PAUL B	10 percent owner	2.84M
ALAM KAMRAN	CHIEF FINANCIAL OFFICER	1.44M
NAGENDRAN SUKUMAR	President and Head of R&D	1.32M
STALFORT JOHN A III	director	884.29K
PRASAD SUYASH	CMO and Head of R&D	539.55K
DONENBERG PHILLIP B.	director	114.11K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Feb 04, 2026	ALAM KAMRAN	SALE	4.52	1.66K	7.48K	1.44M
Jan 26, 2026	ALAM KAMRAN	SALE	4.61	23.85K	109.94K	1.44M
Jan 26, 2026	NAGENDRAN SUKUMAR	SALE	4.61	26.92K	124.09K	1.32M
Jan 26, 2026	NOLAN SEAN P.	SALE	4.61	41.31K	190.45K	2.91M
Jan 23, 2026	ALAM KAMRAN	SALE	4.75	78.97K	375.1K	1.47M
Jan 23, 2026	NOLAN SEAN P.	SALE	4.75	136.79K	649.75K	2.95M
Jan 23, 2026	NAGENDRAN SUKUMAR	SALE	4.75	89.13K	423.38K	1.34M
Jan 12, 2026	NAGENDRAN SUKUMAR	SALE	4.71	200K	942K	1.01M
Dec 01, 2025	NAGENDRAN SUKUMAR	SALE	4.51	260.05K	1.17M	1.01M
Nov 28, 2025	NAGENDRAN SUKUMAR	SALE	4.75	110.13K	523.09K	1.01M
Sep 10, 2025	NAGENDRAN SUKUMAR	SALE	3.23	200K	646K	1.01M
Aug 21, 2025	ALAM KAMRAN	SALE	2.85	54.49K	155.3K	1.19M
Aug 21, 2025	NAGENDRAN SUKUMAR	SALE	2.85	57.05K	162.6K	1.17M
May 30, 2025	MANNING PAUL B	PURCHASE	2.75	750K	2.06M	2.84M
Jun 27, 2024	MANNING PAUL B	PURCHASE	2.25	1.33M	3M	1.33M
Nov 17, 2023	MANNING PAUL B	PURCHASE	1.63	100K	163K	16.57M
Aug 24, 2023	ALAM KAMRAN	SALE	2.33	33K	76.89K	258.04K
Aug 16, 2023	MANNING PAUL B	PURCHASE	0.90	16.47M	14.82M	16.47M
Aug 16, 2023	STALFORT JOHN A III	PURCHASE	0.90	388.89K	350K	884.29K
Aug 16, 2023	NOLAN SEAN P.	PURCHASE	0.90	444.44K	400K	1.54M
Aug 16, 2023	DONENBERG PHILLIP B.	PURCHASE	0.90	111.11K	100K	114.11K
Jul 13, 2023	SESSION R.A. II	SALE	0.70	5.34K	3.74K	8.87M
Jul 12, 2023	SESSION R.A. II	SALE	0.71	80.53K	57.03K	8.88M
Jun 23, 2023	SESSION R.A. II	SALE	0.70	18.1K	12.74K	8.96M
Jun 22, 2023	SESSION R.A. II	SALE	0.70	10.51K	7.38K	8.98M
Jun 21, 2023	SESSION R.A. II	SALE	0.70	138.96K	97.63K	8.99M
Jun 20, 2023	SESSION R.A. II	SALE	0.71	295.65K	210.21K	9.13M
May 16, 2023	NAGENDRAN SUKUMAR	PURCHASE	0.68	5K	3.4K	34.23K
Oct 31, 2022	MANNING PAUL B	PURCHASE	2.00	1.5M	3M	1.64M
Aug 23, 2022	ALAM KAMRAN	SALE	3.47	3.33K	11.54K	266.12K
Aug 22, 2022	ALAM KAMRAN	SALE	3.50	9.72K	34.01K	269.45K
Aug 18, 2022	ALAM KAMRAN	SALE	3.75	11.48K	43.06K	279.16K
Jul 05, 2022	PRASAD SUYASH	SALE	3.51	3.91K	13.71K	539.55K
Jun 29, 2022	PRASAD SUYASH	SALE	3.81	12.32K	46.95K	581.27K
Feb 03, 2022	MANNING PAUL B	PURCHASE	7.84	50K	392K	142.2K
Feb 02, 2022	MANNING PAUL B	PURCHASE	7.77	22K	170.94K	22K
Feb 02, 2022	DONENBERG PHILLIP B.	PURCHASE	7.78	3K	23.34K	3K
Feb 02, 2022	NAGENDRAN SUKUMAR	PURCHASE	8.01	10K	80.1K	29.23K
Nov 24, 2021	MANNING PAUL B	PURCHASE	13.19	2.2K	29.04K	34.2K
Nov 23, 2021	SESSION R.A. II	PURCHASE	12.12	16.51K	200.1K	9.16M
Nov 23, 2021	MANNING PAUL B	PURCHASE	12.54	20K	250.8K	32K
Aug 20, 2021	ALAM KAMRAN	SALE	17.14	2.09K	35.89K	298.12K
Aug 19, 2021	ALAM KAMRAN	SALE	17.11	613	10.49K	309.96K
Aug 18, 2021	ALAM KAMRAN	SALE	17.35	11.19K	194.2K	319.93K
Jul 01, 2021	PRASAD SUYASH	SALE	21.12	19.71K	416.19K	593.59K
Jun 30, 2021	PRASAD SUYASH	SALE	23.70	500	11.85K	613.3K
Jun 29, 2021	PRASAD SUYASH	SALE	25.19	300	7.56K	633.37K
May 20, 2021	NOLAN SEAN P.	PURCHASE	22.35	1.17K	26.15K	1.17K
May 14, 2021	MANNING PAUL B	PURCHASE	20.98	12K	251.76K	12K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES1.17M11

NET SHARES-1.17M11

SHARES HELD16.9M11

% NET SHARES-106.92%0%

Frequently Asked Questions