How many institutions own SRRK stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own SRRK shares is 346, representing 119.12% of the company's common stock.

Who are the major shareholders selling Scholar Rock Holding Corporation stock?

EVENTIDE ASSET MANAGEMENT, LLC, in the last quarter, reduced its stake in SRRK by -3.91% restricting it's holding to 2.8 million shares of worth nearly $104.27M. REDMILE GROUP, LLC also lessened -0.63% of the SRRK shares from its portfolio, reducing its holding to 3.9 million shares of worth $145.40M. PRICE T ROWE ASSOCIATES INC /MD/ also shunned SRRK shares holding by -21.44% last quarter which brought its holding to 6.88 million shares worth $256.33M.

Investors who are buying SRRK stock?

As per its latest 13F filing, GOLDMAN SACHS GROUP INC increased its stake in SRRK by 21.17% in the last quarter. The institutional holder raised its holding to 1.56 million shares having worth more than $58.21M. JENNISON ASSOCIATES LLC also added 339% more shares of SRRK to its portfolio, raising its holding to 1.61 million shares of worth $59.83M. ADAGE CAPITAL PARTNERS GP, L.L.C. also increased its SRRK shares holding by 60.65% which brought its holding to 1.95 million shares worth $72.69M.

SRRK's major insiders: who are they?

The insider with the most stakes in SRRK is Invus Public Equities, L.P. , 10 percent owner at the company. Additionally, SRRK stock is highly held by director Invus Public Equities Advisors, LLC and 10 percent owner Samsara BioCapital GP, LLC among others.

Did an insider recently sell SRRK stock?

Company executives, directors, and other insiders own 3.76% percent of Scholar Rock Holding Corporation's stock. Within the last six months, there have been 11 transaction(s) in which SRRK insiders have sold stock, totaling 270.03K shares. Insiders that have sold shares include QATANANI MO, SINHA VIKAS, and VAISHNAW AKSHAY.

Which insider recently purchased SRRK stock?

There have been 3 transaction(s) during the past 6-months in which Scholar Rock Holding Corporation insiders have bought stock, totalling 42221 shares

How much of SRRK does insiders own?

Around 4.9M Scholar Rock Holding Corporation shares are held by insiders, which represents about 3.76% of SRRK stock.

Who is the insider with the largest stake?

SRRK 10 percent owner, Invus Public Equities, L.P. holds the largest portfolio of the company's shares. SRRK shares owned by Invus total nearly 9.25 million.

Which institution holds the most shares in SRRK?

GOLDMAN SACHS GROUP INC is the largest institutional owner in SRRK which holds 1.56 million shares worth $58.21M or 1.39% of the total SRRK shares outstanding followed by JENNISON ASSOCIATES LLC with ownership of 1.61 million shares representing 1.43% of the SRRK ownership. FAIRMOUNT FUNDS MANAGEMENT LLC is the third largest stakeholder with 1.82 million shares or 1.62% of the ownership worth more than $67.93M.

Is Scholar Rock Holding Corporation stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the SRRK is concerned, it is a stock which is optionable.

Is there a short position on SRRK's shares?

Number of SRRK shares short is 15.47M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding SRRK shares are there?

As of today, 96.13M shares of SRRK are outstanding.

Is there many float in SRRK stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, SRRK has 80.45M shares in float.

SRRK short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for SRRK is 9.54.

Scholar Rock Holding (SRRK) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares16.09

Short Percent Of Float28.19

Shares Outstanding96.13M

Shares Float80.45M

Shares Short15.47M

Short Ratio9.54

28.19%

Short % of Float

16.09%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

3.76% Percentage of Shares held by All Insiders

119.12% Percentage of Shares held by All Institutions

123.77% Percentage of Float held by Institutions

346

Number of Institutions Holding Shares

Institutional Ownership

About 119.12% of SRRK shares are held by financial institutions. GOLDMAN SACHS GROUP INC is the top corporate investor, holding 1.56M shares valued at $58.21M. A 1.39% stake in Scholar Rock Holding Corporation is owned by the company. JENNISON ASSOCIATES LLC owns 1.61M shares valued at $59.83M, which translates its holding of 1.43% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.39%	1.56M	58.21M	273.12K	+21.17%
Sep 30, 2025	JENNISON ASSOCIATES LLC	1.43%	1.61M	59.83M	1.24M	+339.00%
Sep 30, 2025	FAIRMOUNT FUNDS MANAGEMENT LLC	1.62%	1.82M	67.93M	0	0
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.73%	1.95M	72.69M	736.87K	+60.65%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.73%	1.95M	72.81M	67.4K	+3.57%
Sep 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	1.78%	2.01M	74.84M	409.19K	+25.57%
Sep 30, 2025	HOOD RIVER CAPITAL MANAGEMENT LLC	1.79%	2.01M	75.02M	39.43K	+2.00%
Sep 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	1.8%	2.02M	75.37M	846.44K	+71.88%
Sep 30, 2025	HOLOCENE ADVISORS, LP	2.18%	2.46M	91.67M	2.46M	+100.00%
Sep 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	2.48%	2.8M	104.27M	-113.79K	-3.91%
Sep 30, 2025	BELLEVUE GROUP AG	2.88%	3.24M	120.83M	297.24K	+10.09%
Sep 30, 2025	STATE STREET CORP	3.34%	3.76M	140.14M	688.81K	+22.41%
Sep 30, 2025	REDMILE GROUP, LLC	3.46%	3.9M	145.4M	-24.58K	-0.63%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	4.03%	4.55M	169.29M	2.52M	+124.50%
Sep 30, 2025	VANGUARD GROUP INC	4.36%	4.91M	183.03M	53.33K	+1.10%
Sep 30, 2025	SAMSARA BIOCAPITAL, LLC	4.98%	5.61M	209.02M	0	0
Sep 30, 2025	BLACKROCK, INC.	6%	6.76M	251.75M	64.31K	+0.96%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	6.11%	6.88M	256.33M	-1.88M	-21.44%
Sep 30, 2025	SIREN, L.L.C.	8.21%	9.25M	344.47M	0	0
Sep 30, 2025	FMR LLC	12.43%	14.01M	521.81M	177.2K	+1.28%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	48.36K	1.8M	0	0
Sep 30, 2025	RICE HALL JAMES & ASSOCIATES, LLC	0.05%	50.94K	1.9M	-5.77K	-10.18%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.05%	51.29K	1.91M	7.99K	+18.44%
Sep 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.05%	61.83K	2.3M	7.28K	+13.34%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.06%	64.73K	2.41M	-7.07K	-9.85%
Sep 30, 2025	INVESCO LTD.	0.06%	68.17K	2.54M	6.21K	+10.02%
Sep 30, 2025	E. OHMAN J:OR ASSET MANAGEMENT AB	0.06%	69.89K	2.6M	5.32K	+8.24%
Sep 30, 2025	AISLING CAPITAL MANAGEMENT LP	0.07%	77.03K	2.87M	77.03K	+100.00%
Sep 30, 2025	EFG ASSET MANAGEMENT (NORTH AMERICA) CORP.	0.08%	88.11K	3.28M	36.63K	+71.15%
Sep 30, 2025	MOODY ALDRICH PARTNERS LLC	0.09%	101.74K	3.79M	35.48K	+53.55%
Sep 30, 2025	SEI INVESTMENTS CO	0.1%	117.31K	4.37M	28.16K	+31.59%
Sep 30, 2025	SWISS NATIONAL BANK	0.11%	119.6K	4.45M	-7.4K	-5.83%
Sep 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.11%	119.93K	4.47M	46.03K	+62.29%
Sep 30, 2025	RHUMBLINE ADVISERS	0.11%	123.76K	4.61M	-1.62K	-1.29%
Sep 30, 2025	JEFFERIES FINANCIAL GROUP INC.	0.11%	124.6K	4.64M	-9.6K	-7.15%
Sep 30, 2025	HAP TRADING, LLC	0.12%	138.9K	275.06M	138.9K	+100.00%
Sep 30, 2025	CAPTION MANAGEMENT, LLC	0.38%	428.2K	15.95M	143.4K	+50.35%
Sep 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.39%	443.16K	16.5M	67.84K	+18.08%
Sep 30, 2025	NUVEEN, LLC	0.44%	494.16K	18.4M	-2.39K	-0.48%
Sep 30, 2025	JANE STREET GROUP, LLC	0.47%	527.5K	19.64M	437.9K	+488.73%
Sep 30, 2025	FISHER ASSET MANAGEMENT, LLC	0.47%	533.18K	19.86M	120.77K	+29.28%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.13%	141.41K	5.27M	41.55K	+41.61%
Sep 30, 2025	LORD, ABBETT & CO. LLC	0.13%	147.67K	5.5M	-326.47K	-68.86%
Sep 30, 2025	PEREGRINE CAPITAL MANAGEMENT LLC	0.14%	154.9K	5.77M	154.9K	+100.00%
Sep 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.14%	159.74K	5.95M	83K	+108.16%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.15%	172.42K	6.42M	18.54K	+12.05%
Sep 30, 2025	DEUTSCHE BANK AG\	0.17%	197.19K	7.34M	25.24K	+14.68%
Sep 30, 2025	CANDRIAM S.C.A.	0.2%	229.9K	8.56M	-109.43K	-32.25%
Sep 30, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.21%	233.92K	8.71M	-107.09K	-31.40%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.21%	241.63K	9M	19.2K	+8.63%
Sep 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.23%	259.79K	9.97M	67.79K	+35.31%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.28%	312.4K	11.63M	-21.23K	-6.36%
Sep 30, 2025	STEMPOINT CAPITAL LP	0.64%	726.2K	27.04M	198.09K	+37.51%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.65%	733.6K	27.32M	89.37K	+13.87%
Sep 30, 2025	NORTHERN TRUST CORP	0.66%	738.7K	27.51M	1.91K	+0.26%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.6%	677.04K	25.21M	41.14K	+6.47%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.61%	685.96K	25.55M	-6.71K	-0.97%
Sep 30, 2025	JPMORGAN CHASE & CO	0.63%	713.99K	26.59M	440.4K	+160.97%
Sep 30, 2025	ROYAL BANK OF CANADA	0.64%	724.04K	26.96M	316.36K	+77.60%
Sep 30, 2025	LOOMIS SAYLES & CO L P	0.64%	724.24K	26.97M	-18.7K	-2.52%
Sep 30, 2025	NATIONALE-NEDERLANDEN POWSZECHNE TOWARZYSTWO EMERYTALNE S.A.	0.68%	769.44K	28.65M	0	0
Sep 30, 2025	POLAR CAPITAL HOLDINGS PLC	0.7%	794.08K	29.57M	-705.92K	-47.06%
Sep 30, 2025	BARCLAYS PLC	0.31%	344.68K	12.84M	59.36K	+20.81%
Sep 30, 2025	CLEARBRIDGE INVESTMENTS, LLC	0.31%	348.45K	12.98M	64.04K	+22.52%
Sep 30, 2025	EAGLE HEALTH INVESTMENTS LP	0.32%	363.3K	13.53M	93.9K	+34.86%
Sep 30, 2025	MORGAN STANLEY	0.54%	604K	22.49M	-300.39K	-33.21%
Sep 30, 2025	JANUS HENDERSON GROUP PLC	2.67%	3.01M	112.17M	563.16K	+22.98%
Sep 30, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.49%	550.8K	20.51M	550.8K	+100.00%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.5%	558.7K	20.81M	-374.73K	-40.15%
Sep 30, 2025	IKARIAN CAPITAL, LLC	0.5%	561.6K	20.91M	461.6K	+461.60%
Sep 30, 2025	ENSIGN PEAK ADVISORS, INC	0.58%	652.24K	24.29M	51.6K	+8.59%
Sep 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.7%	794.13K	29.57M	0	0
Sep 30, 2025	FEDERATED HERMES, INC.	0.71%	800.46K	29.81M	559.46K	+232.14%
Sep 30, 2025	WOODLINE PARTNERS LP	0.77%	871.05K	32.44M	-73.38K	-7.77%
Sep 30, 2025	MARSHALL WACE, LLP	0.86%	973.91K	36.27M	-666.52K	-40.63%
Sep 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.89%	1.01M	37.49M	874.38K	+660.67%
Sep 30, 2025	CAPITAL WORLD INVESTORS	1%	1.13M	42.03M	0	0
Sep 30, 2025	UBS GROUP AG	1%	1.13M	42.15M	792.76K	+233.83%
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	1.04%	1.17M	43.45M	30.34K	+2.67%
Sep 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.17%	1.32M	49.27M	335.47K	+33.97%
Sep 30, 2025	VESTAL POINT CAPITAL, LP	1.33%	1.5M	55.86M	0	0
Jun 30, 2025	CITADEL ADVISORS LLC	0.87%	976.63K	34.59M	9.08K	+0.94%
Jun 30, 2025	NUVEEN, LLC	0.44%	496.55K	17.59M	99.21K	+24.97%
Jun 30, 2025	NORTHERN TRUST CORP	0.65%	736.79K	26.1M	-28.49K	-3.72%
Jun 30, 2025	MORGAN STANLEY	0.8%	904.39K	32.03M	50.95K	+5.97%
Jun 30, 2025	WOODLINE PARTNERS LP	0.84%	944.43K	33.45M	84.13K	+9.78%
Jun 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.88%	987.46K	34.98M	898.44K	+1,009.17%
Jun 30, 2025	CAPITAL WORLD INVESTORS	1%	1.13M	39.98M	0	0
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	1.01%	1.14M	40.25M	0	0
Jun 30, 2025	SPHERA FUNDS MANAGEMENT LTD.	0.05%	57.5K	2.04M	-20.7K	-26.47%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.08%	1.22M	43.04M	-803K	-39.79%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	1.14%	1.29M	45.69M	-114.45K	-8.15%
Jun 30, 2025	VESTAL POINT CAPITAL, LP	1.33%	1.5M	53.13M	200K	+15.38%
Jun 30, 2025	FISHER ASSET MANAGEMENT, LLC	0.37%	412.41K	14.61M	-44.46K	-9.73%
Jun 30, 2025	LORD, ABBETT & CO. LLC	0.42%	474.14K	16.79M	-403.23K	-45.96%
Jun 30, 2025	STEMPOINT CAPITAL LP	0.47%	528.12K	18.71M	-38.1K	-6.73%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.57%	644.23K	22.82M	317.85K	+97.38%
Jun 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	1.42%	1.6M	56.69M	1.6M	+100.00%
Jun 30, 2025	NATIONALE-NEDERLANDEN POWSZECHNE TOWARZYSTWO EMERYTALNE S.A.	0.68%	769.44K	27.25M	455.75K	+145.29%
Jun 30, 2025		0.44%	496.55K	17.59M	99.21K	+24.97%
Jun 30, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.3%	341.01K	12.08M	341.01K	+100.00%
Jun 30, 2025	ARTIA GLOBAL PARTNERS LP	0.11%	126.29K	4.47M	-45.9K	-26.66%
Jun 30, 2025	RAYMOND JAMES FINANCIAL INC	0.11%	125.48K	4.44M	64.1K	+104.43%
Jun 30, 2025	IKARIAN CAPITAL, LLC	0.09%	100K	3.54M	0	0
Jun 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.09%	99.86K	3.54M	-11.82K	-10.58%
Jun 30, 2025	EXOME ASSET MANAGEMENT LLC	0.07%	84.34K	2.99M	0	0
Jun 30, 2025	NORGES BANK	1.04%	1.18M	41.63M	1.18M	+100.00%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.67%	1.89M	66.86M	39.96K	+2.16%
Jun 30, 2025	LOOMIS SAYLES & CO L P	0.66%	742.94K	26.31M	-17.71K	-2.33%
Jun 30, 2025	ROYAL BANK OF CANADA	0.36%	407.69K	14.44M	407.58K	+388,172.38%
Jun 30, 2025	CAPTION MANAGEMENT, LLC	0.33%	367.7K	13.02M	30K	+8.88%
Jun 30, 2025	JENNISON ASSOCIATES LLC	0.32%	365.95K	12.96M	365.95K	+100.00%
Jun 30, 2025	CANDRIAM S.C.A.	0.3%	339.33K	12.02M	-157.42K	-31.69%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	1.8%	2.02M	71.72M	179.87K	+9.75%
Jun 30, 2025	JANUS HENDERSON GROUP PLC	2.17%	2.45M	86.73M	780.1K	+46.71%
Jun 30, 2025	STATE STREET CORP	2.73%	3.07M	108.89M	-59.84K	-1.91%
Jun 30, 2025	VANGUARD GROUP INC	4.31%	4.86M	172.2M	16.39K	+0.34%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	7.77%	8.76M	310.34M	-132.24K	-1.49%
Jun 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.83%	933.43K	33.06M	933.43K	+100.00%
Jun 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.7%	794.13K	28.13M	32.59K	+4.28%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.56%	635.89K	22.52M	18.78K	+3.04%
Jun 30, 2025	TFG ASSET MANAGEMENT GP LTD	0.09%	103.48K	3.67M	103.48K	+100.00%
Jun 30, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.11%	125K	4.43M	-160K	-56.14%
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.12%	132.35K	4.69M	132.35K	+100.00%
Jun 30, 2025	GRANAHAN INVESTMENT MANAGEMENT, LLC	0.07%	73.38K	2.6M	73.38K	+100.00%
Jun 30, 2025	MOODY ALDRICH PARTNERS LLC	0.06%	66.26K	2.35M	38.9K	+142.13%
Jun 30, 2025	E. OHMAN J:OR ASSET MANAGEMENT AB	0.06%	64.57K	2.29M	7.38K	+12.91%
Jun 30, 2025	JASPER RIDGE PARTNERS, L.P.	0.06%	64.17K	2.27M	0	0
Jun 30, 2025	GREAT POINT PARTNERS LLC	0.05%	61.61K	2.18M	61.61K	+100.00%
Jun 30, 2025	JEFFERIES FINANCIAL GROUP INC.	0.12%	134.2K	4.75M	0	0
Jun 30, 2025	D. E. SHAW & CO., INC.	0.12%	136.28K	4.83B	-181.36K	-57.10%
Jun 30, 2025	PATIENT SQUARE CAPITAL LP	0.14%	154K	5.45M	0	0
Jun 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.17%	192K	6.8M	131.46K	+217.14%
Jun 30, 2025	CLEARBRIDGE INVESTMENTS, LLC	0.25%	284.41K	10.07M	-59.08K	-17.20%
Jun 30, 2025	TD ASSET MANAGEMENT INC	0.3%	333.63K	11.82M	-5.39K	-1.59%
Jun 30, 2025	POLAR CAPITAL HOLDINGS PLC	1.33%	1.5M	53.13M	-1.08M	-41.94%
Jun 30, 2025	MARSHALL WACE, LLP	1.46%	1.64M	58.1M	5.14K	+0.31%
Jun 30, 2025	FAIRMOUNT FUNDS MANAGEMENT LLC	1.62%	1.82M	64.61M	450K	+32.75%
Jun 30, 2025	HOOD RIVER CAPITAL MANAGEMENT LLC	1.75%	1.97M	69.95M	30.81K	+1.58%
Jun 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	2.58%	2.91M	103.19M	251.64K	+9.45%
Jun 30, 2025	ENSIGN PEAK ADVISORS, INC	0.53%	600.64K	21.27M	264.69K	+78.79%
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	0.61%	692.68K	24.53M	28.75K	+4.33%
Jun 30, 2025	MAN GROUP PLC	0.53%	601.15K	21.29M	-386.56K	-39.14%
Jun 30, 2025	BELLEVUE GROUP AG	2.62%	2.95M	104.39M	440.41K	+17.57%
Jun 30, 2025	BLACKROCK, INC.	5.94%	6.7M	237.17M	-611.39K	-8.37%
Jun 30, 2025	SIREN, L.L.C.	8.21%	9.25M	327.64M	0	0
Jun 30, 2025	INTEGRAL HEALTH ASSET MANAGEMENT, LLC	0.09%	100K	3.54M	-25K	-20.00%
Jun 30, 2025	EAGLE HEALTH INVESTMENTS LP	0.24%	269.4K	9.54M	269.4K	+100.00%
Jun 30, 2025	FMR LLC	12.28%	13.83M	490.03M	40.39K	+0.29%
Jun 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.04%	45.29K	1.6M	-11.49K	-20.24%
Jun 30, 2025	CINCTIVE CAPITAL MANAGEMENT LP	0.04%	45.42K	1.61M	45.42K	+100.00%
Jun 30, 2025	STATE OF WISCONSIN INVESTMENT BOARD	0.04%	49.96K	1.77M	-24.93K	-33.28%
Jun 30, 2025	MASTERS CAPITAL MANAGEMENT LLC	0.04%	50K	1.77M	50K	+100.00%
Jun 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.05%	54.56K	1.93M	46.72K	+596.40%
Jun 30, 2025	RICE HALL JAMES & ASSOCIATES, LLC	0.05%	56.72K	2.01M	3.15K	+5.89%
Jun 30, 2025	SAMSARA BIOCAPITAL, LLC	4.98%	5.61M	198.81M	0	0
Jun 30, 2025	REDMILE GROUP, LLC	3.49%	3.93M	139.17M	-469.24K	-10.67%
Jun 30, 2025	COMMODORE CAPITAL LP	1.29%	1.45M	51.36M	-295K	-16.91%
Jun 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.33%	375.32K	13.29M	241.13K	+179.71%
Jun 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	1.04%	1.18M	41.71M	663.42K	+129.05%
Mar 31, 2025	SIREN, L.L.C.	8.27%	9.25M	297.39M	0	0
Mar 31, 2025		0.36%	397.34K	12.77M	397.34K	+100.00%
Mar 31, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.25%	285K	9.16M	117.46K	+70.11%
Mar 31, 2025	STATE STREET CORP	2.8%	3.13M	100.76M	494.85K	+18.75%
Mar 31, 2025	FISHER ASSET MANAGEMENT, LLC	0.41%	456.87K	14.69M	-97.87K	-17.64%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.33%	372.74K	11.98M	-24.81K	-6.24%
Mar 31, 2025	VANGUARD GROUP INC	4.33%	4.85M	155.77M	101.72K	+2.14%
Mar 31, 2025	REDMILE GROUP, LLC	3.93%	4.4M	141.4M	-151.6K	-3.33%
Mar 31, 2025	EVENTIDE ASSET MANAGEMENT, LLC	2.38%	2.66M	85.58M	2.37K	+0.09%
Mar 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.8%	2.02M	64.88M	423.13K	+26.53%
Mar 31, 2025	HOOD RIVER CAPITAL MANAGEMENT LLC	1.74%	1.94M	62.5M	45.52K	+2.40%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.65%	1.85M	59.41M	77.13K	+4.36%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	1.65%	1.84M	59.32M	119.38K	+6.92%
Mar 31, 2025	COMMODORE CAPITAL LP	1.56%	1.75M	56.1M	795K	+83.68%
Mar 31, 2025	JANUS HENDERSON GROUP PLC	1.49%	1.67M	54.81M	821.01K	+96.68%
Mar 31, 2025	MARSHALL WACE, LLP	1.46%	1.64M	52.57M	-1.31M	-44.48%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	1.26%	1.4M	45.15M	-316.16K	-18.38%
Mar 31, 2025	VESTAL POINT CAPITAL, LP	1.16%	1.3M	41.8M	1.3M	+100.00%
Mar 31, 2025	CAPITAL WORLD INVESTORS	1.01%	1.13M	36.29M	406.8K	+56.35%
Mar 31, 2025	TD ASSET MANAGEMENT INC	0.3%	339.02K	10.9M	-23.79K	-6.56%
Mar 31, 2025	ENSIGN PEAK ADVISORS, INC	0.3%	335.95K	10.8M	147.97K	+78.72%
Mar 31, 2025	OCTAGON CAPITAL ADVISORS LP	0.29%	329K	10.58M	-159K	-32.58%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.29%	326.39K	10.49M	143.69K	+78.65%
Mar 31, 2025	D. E. SHAW & CO., INC.	0.28%	317.65K	10.21M	-349.24K	-52.37%
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	1.02%	1.14M	36.54M	1.12M	+6,351.25%
Mar 31, 2025	LOOMIS SAYLES & CO L P	0.68%	760.65K	24.46M	-16.02K	-2.06%
Mar 31, 2025	CAPTION MANAGEMENT, LLC	0.3%	337.7K	10.86M	31.1K	+10.14%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.28%	317.4K	10.2M	271.7K	+594.53%
Mar 31, 2025	NATIONALE-NEDERLANDEN POWSZECHNE TOWARZYSTWO EMERYTALNE S.A.	0.28%	313.69K	10.09M	-72.24K	-18.72%
Mar 31, 2025	FMR LLC	12.33%	13.79M	443.49M	159.23K	+1.17%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	7.95%	8.89M	285.94M	-389.54K	-4.20%
Mar 31, 2025	POLAR CAPITAL HOLDINGS PLC	2.31%	2.58M	83.06M	-125K	-4.62%
Mar 31, 2025	BELLEVUE GROUP AG	2.24%	2.51M	80.6M	-3.8K	-0.15%
Mar 31, 2025	MAN GROUP PLC	0.88%	987.71K	31.75M	987.71K	+100.00%
Mar 31, 2025	CANDRIAM S.C.A.	0.44%	496.76K	15.97M	-85.6K	-14.70%
Mar 31, 2025	CLEARBRIDGE INVESTMENTS, LLC	0.31%	343.49K	11.04M	-77.89K	-18.48%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.55%	617.11K	19.84M	-5.3K	-0.85%
Mar 31, 2025	NORTHERN TRUST CORP	0.68%	765.28K	24.6M	18.75K	+2.51%
Mar 31, 2025	AMERICAN CENTURY COMPANIES INC	0.59%	663.93K	21.35M	6.96K	+1.06%
Mar 31, 2025	BLACKROCK, INC.	6.53%	7.31M	234.93M	134.9K	+1.88%
Mar 31, 2025	CITADEL ADVISORS LLC	0.87%	967.55K	31.11M	-750.51K	-43.68%
Mar 31, 2025	IKARIAN CAPITAL, LLC	0.22%	244.18K	7.85M	-113.01K	-31.64%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.19%	216.22K	6.95M	8.73K	+4.21%
Mar 31, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.19%	215.41K	6.93M	2.68K	+1.26%
Mar 31, 2025	WOODLINE PARTNERS LP	0.77%	860.31K	27.66M	-229.15K	-21.03%
Mar 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.46%	514.09K	16.53M	-1.91K	-0.37%
Mar 31, 2025	SAMSARA BIOCAPITAL, LLC	5.02%	5.61M	180.45M	0	0
Mar 31, 2025	LORD, ABBETT & CO. LLC	0.78%	877.37K	28.21M	406.07K	+86.16%
Mar 31, 2025	MORGAN STANLEY	0.76%	853.44K	27.44M	440.05K	+106.45%
Mar 31, 2025	STEMPOINT CAPITAL LP	0.51%	566.21K	18.2M	399.91K	+240.46%
Mar 31, 2024	FRED ALGER MANAGEMENT, LLC	0.19%	147.2K	2.61M	-14.68K	-9.07%
Mar 31, 2024	LPL FINANCIAL LLC	0.03%	20.73K	368.15K	20.73K	+100.00%
Mar 31, 2024	CAPSTONE INVESTMENT ADVISORS, LLC	0.03%	21.57K	383.05K	21.57K	+100.00%
Mar 31, 2024	NEW YORK STATE COMMON RETIREMENT FUND	0.03%	22.55K	401K	56	+0.25%
Mar 31, 2024	AMERICAN INTERNATIONAL GROUP, INC.	0.04%	28.41K	504.51K	834	+3.02%
Mar 31, 2024	SIMPLEX TRADING, LLC	0.04%	28.51K	506K	26.38K	+1,237.38%
Mar 31, 2024	STATE OF WISCONSIN INVESTMENT BOARD	0.04%	28.87K	512.73K	-11.81K	-29.03%
Mar 31, 2024	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	29.32K	520.79K	0	0
Mar 31, 2024	SUSQUEHANNA PORTFOLIO STRATEGIES, LLC	0.04%	30.32K	538.5K	30.32K	+100.00%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.04%	33.36K	592.42K	27.53K	+472.36%
Mar 31, 2024	BNP PARIBAS ARBITRAGE, SNC	0.05%	34.28K	608.88K	-14.09K	-29.12%
Mar 31, 2024	HANSEATIC MANAGEMENT SERVICES INC	0.05%	34.99K	621.46K	1.09K	+3.22%
Mar 31, 2024	JPMORGAN CHASE & CO	0.05%	37.91K	673.35K	-12.6K	-24.95%
Mar 31, 2024	DEKABANK DEUTSCHE GIROZENTRALE	0.05%	38K	583K	0	0
Mar 31, 2024	ENSIGN PEAK ADVISORS, INC	0.05%	38.97K	692.18K	-1.97K	-4.80%
Mar 31, 2024	RICE HALL JAMES & ASSOCIATES, LLC	0.06%	44.41K	788.65K	326	+0.74%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.06%	45.11K	801.19M	-1.89K	-4.02%
Mar 31, 2024	JUMP FINANCIAL, LLC	0.06%	46.64K	828.24K	46.64K	+100.00%
Mar 31, 2024	CREDIT SUISSE AG/	0.07%	52.56K	933.45K	-5.27K	-9.11%
Mar 31, 2024	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.07%	53.22K	945.12K	53.22K	+100.00%
Mar 31, 2024	PROFUND ADVISORS LLC	0.07%	53.62K	952.33M	35.28K	+192.35%
Mar 31, 2024	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.07%	55.75K	990K	22.02K	+65.29%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.07%	56.87K	1.01M	31.93K	+128.03%
Mar 31, 2024	CLARIVEST ASSET MANAGEMENT LLC	0.08%	57.92K	1.03M	-11.49K	-16.55%
Mar 31, 2024	SWISS NATIONAL BANK	0.1%	78.3K	1.39M	-19.8K	-20.18%
Mar 31, 2024	RHUMBLINE ADVISERS	0.12%	94.06K	1.67M	4.31K	+4.80%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.05%	36.8K	653.57K	36.8K	+100.00%
Mar 31, 2024	INVESCO LTD.	0.13%	96.54K	1.71M	-210.5K	-68.56%
Mar 31, 2024	FISHER ASSET MANAGEMENT, LLC	0.14%	105.83K	1.88M	-7.33K	-6.48%
Mar 31, 2024	CANADA PENSION PLAN INVESTMENT BOARD	0.16%	120K	2.13M	0	0
Mar 31, 2024	TREXQUANT INVESTMENT LP	0.18%	138.07K	2.45M	65.79K	+91.01%
Mar 31, 2024	JENNISON ASSOCIATES LLC	0.18%	138.46K	2.46M	1.41K	+1.03%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.37%	282.74K	5.02M	-54.55K	-16.17%
Mar 31, 2024	WELLINGTON MANAGEMENT GROUP LLP	0.21%	157.28K	2.79M	85.64K	+119.54%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.26%	196.98K	3.5M	14.6K	+8.00%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.31%	238.75K	4.24M	201.45K	+540.11%
Mar 31, 2024	POINT72 ASSET MANAGEMENT, L.P.	0.32%	242.16K	4.3M	-889.51K	-78.60%
Mar 31, 2024	JANE STREET GROUP, LLC	0.32%	244.32K	4.34M	119.36K	+95.52%
Mar 31, 2024	MORGAN STANLEY	0.34%	257.46K	4.57M	-326.71K	-55.93%
Mar 31, 2024	SIO CAPITAL MANAGEMENT, LLC	0.36%	273.72K	4.86M	273.72K	+100.00%
Mar 31, 2024	KENNEDY CAPITAL MANAGEMENT LLC	0.36%	275.89K	4.9M	275.89K	+100.00%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	0.38%	289.24K	5.14M	-41.1K	-12.44%
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.41%	309.65K	5.5M	-30.25K	-8.90%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.42%	320.82K	5.7M	240.86K	+301.24%
Mar 31, 2024	INTEGRAL HEALTH ASSET MANAGEMENT, LLC	0.43%	325K	5.77M	225K	+225.00%
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	0.46%	345.76K	6.14M	238.05K	+221.02%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	0.47%	357.07K	6.34M	111.61K	+45.47%
Mar 31, 2024	IKARIAN CAPITAL, LLC	0.38%	291.7K	5.18M	291.7K	+100.00%
Mar 31, 2024	AXA S.A.	0.49%	372.04K	6.61M	-154.97K	-29.40%
Mar 31, 2024	AMERIPRISE FINANCIAL INC	0.51%	389.5K	6.92M	108.65K	+38.69%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.53%	402.48K	7.15M	8.34K	+2.12%
Mar 31, 2024	UBS GROUP AG	0.57%	432.46K	7.68M	432.22K	+177,866.67%
Mar 31, 2024	NORTHERN TRUST CORP	0.68%	515.84K	9.16M	1.34K	+0.26%
Mar 31, 2024	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.69%	525K	9.32M	-775K	-59.62%
Mar 31, 2024	LAURION CAPITAL MANAGEMENT LP	0.69%	525.06K	9.32M	72.91K	+16.13%
Mar 31, 2024	CITIGROUP INC	0.71%	536.33K	9.53M	486.62K	+978.92%
Mar 31, 2024	BALYASNY ASSET MANAGEMENT L.P.	0.74%	562.22K	9.99M	562.22K	+100.00%
Mar 31, 2024	CITADEL ADVISORS LLC	0.85%	644.79K	11.45M	105.94K	+19.66%
Mar 31, 2024	DEEP TRACK CAPITAL, LP	0.9%	680K	12.08M	-331.83K	-32.80%
Mar 31, 2024	HOOD RIVER CAPITAL MANAGEMENT LLC	1.04%	792.05K	14.07M	292.9K	+58.68%
Mar 31, 2024	WOODLINE PARTNERS LP	1.4%	1.06M	18.86M	136.87K	+14.80%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	1.62%	1.23M	21.88M	-198.62K	-13.88%
Mar 31, 2024	EVENTIDE ASSET MANAGEMENT, LLC	1.99%	1.51M	26.88M	540.55K	+55.57%
Mar 31, 2024	BELLEVUE GROUP AG	2.85%	2.17M	38.45M	-3.72K	-0.17%
Mar 31, 2024	POLAR CAPITAL HOLDINGS PLC	3.87%	2.94M	52.23M	0	0
Mar 31, 2024	ORBIMED ADVISORS LLC	4.7%	3.57M	63.49M	-670.37K	-15.79%
Mar 31, 2024	STATE STREET CORP	5.49%	4.17M	74.06M	2.01M	+93.10%
Mar 31, 2024	REDMILE GROUP, LLC	8.45%	6.42M	114.01M	17.11K	+0.27%
Mar 31, 2024	PRICE T ROWE ASSOCIATES INC /MD/	10.8%	8.21M	145.78M	-113.36K	-1.36%
Mar 31, 2024	SAMSARA BIOCAPITAL, LLC	8.93%	6.79M	120.57M	0	0
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	1.57%	1.19M	21.16M	49.71K	+4.35%
Mar 31, 2024	VANGUARD GROUP INC	3.91%	2.97M	52.74M	114.55K	+4.01%
Mar 31, 2024	BLACKROCK INC.	6.59%	5.01M	88.9M	43.29K	+0.87%
Mar 31, 2024	FMR LLC	13.95%	10.6M	188.3M	187.84K	+1.80%
Mar 31, 2024	ARTAL GROUP S.A.	14.82%	11.26M	199.97M	0	0
Mar 31, 2024	ABRDN PLC	0.22%	169K	3M	0	0
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.22%	170.47K	3.03M	4.9K	+2.96%
Mar 31, 2024	CUBIST SYSTEMATIC STRATEGIES, LLC	0.23%	174.98K	3.11M	174.98K	+100.00%
Mar 31, 2024	SILVERARC CAPITAL MANAGEMENT, LLC	0.26%	199.42K	3.54M	-70.59K	-26.14%
Mar 31, 2024	ROYAL BANK OF CANADA	0.29%	219.79K	3.9M	202.48K	+1,169.99%
Dec 31, 2023	EVENTIDE ASSET MANAGEMENT, LLC	1.21%	972.73K	18.29M	972.73K	+100.00%
Dec 31, 2023	DEEP TRACK CAPITAL, LP	1.26%	1.01M	19.02M	657.97K	+185.94%
Dec 31, 2023	POINT72 ASSET MANAGEMENT, L.P.	1.4%	1.13M	21.28M	1.13M	+100.00%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.42%	1.14M	21.46M	288.48K	+33.82%
Dec 31, 2023	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.61%	1.3M	24.44M	1.3M	+100.00%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	1.78%	1.43M	26.9M	342.69K	+31.50%
Dec 31, 2023	STATE STREET CORP	2.68%	2.16M	40.6M	1.35M	+165.28%
Dec 31, 2023	BELLEVUE GROUP AG	2.69%	2.17M	40.78M	31K	+1.45%
Dec 31, 2023	VANGUARD GROUP INC	3.54%	2.85M	53.67M	802.27K	+39.08%
Dec 31, 2023	POLAR CAPITAL HOLDINGS PLC	3.65%	2.94M	55.28M	1.44M	+95.79%
Dec 31, 2023	ORBIMED ADVISORS LLC	5.27%	4.25M	79.81M	2.21M	+108.72%
Dec 31, 2023	BLACKROCK INC.	6.16%	4.96M	93.3M	1.48M	+42.58%
Dec 31, 2023	REDMILE GROUP, LLC	7.94%	6.4M	120.37M	1.67M	+35.27%
Dec 31, 2023	SAMSARA BIOCAPITAL, LLC	8.42%	6.79M	127.63M	2.19M	+47.62%
Dec 31, 2023	PRICE T ROWE ASSOCIATES INC /MD/	10.32%	8.32M	156.44M	1.15M	+16.03%
Dec 31, 2023	FMR LLC	12.92%	10.41M	195.79M	2.41M	+30.09%
Dec 31, 2023	ARTAL GROUP S.A.	13.97%	11.26M	211.68M	2.2M	+24.28%
Dec 31, 2023	RHUMBLINE ADVISERS	0.11%	89.75K	1.69M	26.16K	+41.14%
Dec 31, 2023	D. E. SHAW & CO., INC.	0.12%	95.29K	1.79M	26.47K	+38.46%
Dec 31, 2023	SWISS NATIONAL BANK	0.12%	98.1K	1.84M	14.5K	+17.34%
Dec 31, 2023	INTEGRAL HEALTH ASSET MANAGEMENT, LLC	0.12%	100K	1.88M	100K	+100.00%
Dec 31, 2023	RAFFERTY ASSET MANAGEMENT, LLC	0.13%	107.71K	2.02M	107.71K	+100.00%
Dec 31, 2023	FISHER ASSET MANAGEMENT, LLC	0.14%	113.16K	2.13M	-27.89K	-19.77%
Dec 31, 2023	CANADA PENSION PLAN INVESTMENT BOARD	0.15%	120K	2.26M	120K	+100.00%
Dec 31, 2023	JANE STREET GROUP, LLC	0.16%	124.96K	2.35M	124.96K	+100.00%
Dec 31, 2023	CINCTIVE CAPITAL MANAGEMENT LP	0.17%	135K	2.54M	135K	+100.00%
Dec 31, 2023	BARCLAYS PLC	0.17%	136.05K	2.56M	103.73K	+320.97%
Dec 31, 2023	JENNISON ASSOCIATES LLC	0.17%	137.05K	2.58M	137.05K	+100.00%
Dec 31, 2023	EAM INVESTORS, LLC	0.18%	142.79K	2.68M	142.79K	+100.00%
Dec 31, 2023	FRED ALGER MANAGEMENT, LLC	0.2%	161.88K	3.04M	161.88K	+100.00%
Dec 31, 2023	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.21%	165.57K	3.11M	16.67K	+11.19%
Dec 31, 2023	ABRDN PLC	0.21%	169K	3.18M	169K	+100.00%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.23%	182.39K	3.43M	59.2K	+48.06%
Dec 31, 2023	TRI LOCUM PARTNERS LP	0.26%	207.15K	3.89M	207.15K	+100.00%
Dec 31, 2023	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.3%	242.13K	4.55M	242.13K	+100.00%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	0.3%	245.46K	4.61M	245.46K	+100.00%
Dec 31, 2023	SILVERARC CAPITAL MANAGEMENT, LLC	0.34%	270K	5.08M	260.29K	+2,680.35%
Dec 31, 2023	AMERIPRISE FINANCIAL INC	0.35%	280.85K	5.28M	280.85K	+100.00%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	0.41%	330.34K	6.22M	38.49K	+13.19%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.42%	337.29K	6.34M	130K	+62.71%
Dec 31, 2023	TD ASSET MANAGEMENT INC	0.42%	339.89K	6.39M	3.6K	+1.07%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.49%	394.14K	7.41M	91.75K	+30.34%
Dec 31, 2023	LAURION CAPITAL MANAGEMENT LP	0.56%	452.15K	8.5M	-101.55K	-18.34%
Dec 31, 2023	HOOD RIVER CAPITAL MANAGEMENT LLC	0.62%	499.14K	9.38M	499.14K	+100.00%
Dec 31, 2023	NORTHERN TRUST CORP	0.64%	514.5K	9.67M	105.07K	+25.66%
Dec 31, 2023	INVESCO LTD.	0.38%	307.04K	5.77M	292.47K	+2,008.34%
Dec 31, 2023	AXA S.A.	0.65%	527.01K	9.91M	-12.75K	-2.36%
Dec 31, 2023	CITADEL ADVISORS LLC	0.67%	538.85K	10.13M	493.13K	+1,078.59%
Dec 31, 2023	MORGAN STANLEY	0.72%	584.16K	10.98M	363.61K	+164.86%
Dec 31, 2023	WOODLINE PARTNERS LP	1.15%	924.88K	17.39M	409.27K	+79.37%

Insiders

Among the SRRK insiders holding of 3.76% of the stake in company, INVUS PUBLIC EQUITIES, L.P., 10 percent owner, holds the largest shares of 9.25M. INVUS PUBLIC EQUITIES ADVISORS, LLC, director, is the second largest SRRK insider with ownership of 8.85M shares. SAMSARA BIOCAPITAL GP, LLC, 10 percent owner, stands third with possession of 6.79M shares of that stake.

Insiders	Designation	Shares Held
INVUS PUBLIC EQUITIES, L.P.	10 percent owner	9.25M
INVUS PUBLIC EQUITIES ADVISORS, LLC	director	8.85M
SAMSARA BIOCAPITAL GP, LLC	10 percent owner	6.79M
SPRINGER TIMOTHY A		3.27M
HALLAL DAVID	Chief Executive Officer	1.54M
VAISHNAW AKSHAY	President of R&D	595.77K
WOODS KEITH	Chief Operating Officer	583.25K
SINHA VIKAS	Chief Financial Officer	583.25K
AKKARAJU SRINIVAS	director	513.24K
ARTAL INTERNATIONAL S.C.A.	10 percent owner	450K
BACKSTROM JAY T.	CHIEF EXECUTIVE OFFICER	311.99K
HO JUNLIN	GENERAL COUNSEL	222.57K
POLARIS VENTURE MANAGEMENT CO. VI, L.L.C.	10 percent owner	156.4K
PARLAVECCHIO CARYN	CHRO	155.46K
MYLES EDWARD H	COO & CFO	111.35K
QATANANI MO	CHIEF SCIENTIFIC OFFICER	108.96K
MOORE ERIN	Interim PFO and PAO	82.61K
SACCO TRACEY	Chief Commercial Officer	71.75K
MARANTZ JING L.	CHIEF MEDICAL OFFICER	67.2K
GILMAN MICHAEL	director	55.22K
PENG KATIE	director	32.91K
CARVEN GREGORY JOHN	Head of Research	26.86K
BUROW KRISTINA	director	21.07K
NASHAT AMIR	director	16.54K
REED JOSHUA	director	15.73K
BRUDNICK RICHARD	director	15.06K
FLIER JEFFREY S.	director	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Jan 14, 2026	QATANANI MO	SALE	45.20	13.11K	592.61K	108.96K
Jan 13, 2026	SINHA VIKAS	SALE	42.70	16.76K	715.44K	583.25K
Jan 13, 2026	VAISHNAW AKSHAY	SALE	42.70	20.44K	872.7K	595.77K
Jan 13, 2026	HALLAL DAVID	SALE	42.70	57.45K	2.45M	1.54M
Jan 13, 2026	WOODS KEITH	SALE	42.70	16.75K	715.05K	583.25K
Dec 16, 2025	PENG KATIE	SALE	44.63	280	12.5K	32.91K
Dec 04, 2025	QATANANI MO	SALE	45.21	136.46K	6.17M	108.96K
Oct 07, 2025	AKKARAJU SRINIVAS	PURCHASE	39.31	12.8K	503.01K	513.24K
Oct 06, 2025	AKKARAJU SRINIVAS	PURCHASE	37.89	18.41K	697.71K	405.83K
Oct 03, 2025	AKKARAJU SRINIVAS	PURCHASE	35.61	11.01K	392.1K	11.01K
Sep 22, 2025	QATANANI MO	SALE	30.67	3.35K	102.85K	108.96K
Sep 16, 2025	QATANANI MO	SALE	33.52	3.18K	106.53K	112.32K
Sep 16, 2025	PENG KATIE	SALE	33.20	76	2.52K	33.91K
Aug 18, 2025	PARLAVECCHIO CARYN	SALE	31.17	2.18K	67.88K	155.46K
Jul 16, 2025	FLIER JEFFREY S.	SALE	40.02	11.14K	445.69K	0
Jul 08, 2025	QATANANI MO	SALE	34.44	24.07K	828.9K	115.5K
Jun 23, 2025	FLIER JEFFREY S.	SALE	33.21	11.14K	369.82K	11.14K
Jun 16, 2025	PENG KATIE	SALE	32.53	54	1.76K	34.92K
Jun 16, 2025	PARLAVECCHIO CARYN	SALE	32.00	6.19K	197.96K	157.64K
Jun 16, 2025	QATANANI MO	SALE	32.00	3.67K	117.38K	139.56K
Jun 16, 2025	HO JUNLIN	SALE	32.00	7.44K	238.15K	222.57K
May 29, 2025	BRUDNICK RICHARD	SALE	30.00	1.4K	42K	15.06K
May 29, 2025	GILMAN MICHAEL	SALE	29.83	2.75K	81.9K	55.22K
May 29, 2025	FLIER JEFFREY S.	SALE	29.84	4.98K	148.43K	24.07K
May 29, 2025	BUROW KRISTINA	SALE	29.83	4.4K	131.27K	21.07K
May 29, 2025	REED JOSHUA	SALE	30.04	500	15.02K	15.73K
May 29, 2025	VAISHNAW AKSHAY	SALE	30.01	1.62K	48.61K	616.21K
Apr 25, 2025	SACCO TRACEY	SALE	33.48	84	2.81K	71.75K
Mar 24, 2025	SACCO TRACEY	SALE	32.89	5K	164.46K	71.75K
Mar 24, 2025	MOORE ERIN	SALE	33.12	13.56K	449.24K	82.61K
Mar 17, 2025	PENG KATIE	SALE	34.42	1.01K	34.63K	30.32K
Mar 10, 2025	MYLES EDWARD H	SALE	34.87	29.4K	1.03M	111.35K
Feb 19, 2025	QATANANI MO	SALE	37.74	20.2K	762.5K	111.08K
Feb 18, 2025	HO JUNLIN	SALE	36.83	5.74K	211.47K	189.3K
Feb 18, 2025	QATANANI MO	SALE	36.83	4.14K	152.29K	131.29K
Feb 18, 2025	PARLAVECCHIO CARYN	SALE	36.83	5.3K	195.05K	140.26K
Feb 18, 2025	MYLES EDWARD H	SALE	36.83	7.81K	287.6K	140.74K
Feb 18, 2025	BACKSTROM JAY T.	SALE	36.83	18.37K	676.62K	311.99K
Jan 16, 2025	BACKSTROM JAY T.	SALE	44.20	22.31K	985.95K	330.36K
Jan 16, 2025	HO JUNLIN	SALE	44.20	9.04K	399.5K	195.04K
Jan 16, 2025	MYLES EDWARD H	SALE	44.20	12.54K	554.19K	148.55K
Jan 16, 2025	PARLAVECCHIO CARYN	SALE	44.20	6.43K	284.36K	145.55K
Jan 16, 2025	QATANANI MO	SALE	44.20	7.35K	324.72K	135.42K
Jan 16, 2025	SACCO TRACEY	SALE	44.20	3.89K	171.93K	45.4K
Jan 16, 2025	MARANTZ JING L.	SALE	44.20	5.66K	249.94K	67.2K
Dec 10, 2024	INVUS PUBLIC EQUITIES, L.P.	SALE	41.65	1.6M	66.64M	9.25M
Nov 25, 2024	INVUS PUBLIC EQUITIES, L.P.	SALE	40.98	149	6.11K	10.85M
Nov 25, 2024	MARANTZ JING L.	SALE	40.72	200	8.14K	72.86K
Nov 22, 2024	MARANTZ JING L.	SALE	30.01	2.15K	64.37K	72.86K
Nov 11, 2024	MARANTZ JING L.	SALE	30.00	2.11K	63.16K	72.86K
Oct 08, 2024	MYLES EDWARD H	SALE	34.90	37.19K	1.3M	161.09K
Oct 07, 2024	AKKARAJU SRINIVAS	SALE	32.50	155.71K	5.06M	5.61M
Oct 07, 2024	MYLES EDWARD H	SALE	29.05	31.25K	907.81K	161.09K
Oct 07, 2024	MARANTZ JING L.	SALE	30.06	39.38K	1.18M	72.86K
Oct 07, 2024	SACCO TRACEY	SALE	26.23	1.96K	51.52K	49.29K
Sep 16, 2024	QATANANI MO	SALE	8.58	1.94K	16.61K	142.77K
Aug 16, 2024	PARLAVECCHIO CARYN	SALE	9.33	1.45K	13.54K	151.99K
Jun 17, 2024	HO JUNLIN	SALE	8.98	4.7K	42.18K	204.08K
Jun 17, 2024	MYLES EDWARD H	SALE	8.98	9.46K	84.98K	201.52K
Jun 17, 2024	PARLAVECCHIO CARYN	SALE	8.98	4.31K	38.68K	153.44K
Jun 17, 2024	QATANANI MO	SALE	8.98	2.32K	20.8K	144.7K
Feb 16, 2024	QATANANI MO	SALE	15.74	2.51K	39.55K	147.02K
Feb 16, 2024	MYLES EDWARD H	SALE	15.74	4.74K	74.69K	210.98K
Feb 16, 2024	PARLAVECCHIO CARYN	SALE	15.74	3.75K	59.05K	157.74K
Feb 16, 2024	HO JUNLIN	SALE	15.74	3.49K	54.93K	208.77K
Feb 16, 2024	BACKSTROM JAY T.	SALE	15.74	11.61K	182.84K	352.67K
Jan 16, 2024	QATANANI MO	SALE	15.93	2K	31.89K	78.82K
Jan 16, 2024	HO JUNLIN	SALE	15.93	4.19K	66.68K	154.41K
Jan 16, 2024	MYLES EDWARD H	SALE	15.93	6.63K	105.67K	162.15K
Jan 16, 2024	PARLAVECCHIO CARYN	SALE	15.93	2.85K	45.38K	114.35K
Dec 29, 2023	MYLES EDWARD H	SALE	19.51	300	5.85K	168.78K
Dec 14, 2023	QATANANI MO	SALE	18.18	24.66K	448.44K	80.82K
Dec 07, 2023	MYLES EDWARD H	SALE	17.53	24.91K	436.82K	168.78K
Nov 02, 2023	MYLES EDWARD H	SALE	12.51	35.01K	438.04K	168.78K
Oct 16, 2023	SAMSARA BIOCAPITAL GP, LLC	PURCHASE	6.85	2.19M	15M	6.79M
Oct 16, 2023	AKKARAJU SRINIVAS	PURCHASE	6.85	2.19M	15M	6.79M
Oct 12, 2023	INVUS PUBLIC EQUITIES, L.P.	PURCHASE	6.85	2.19M	15M	11.25M
Sep 18, 2023	QATANANI MO	SALE	6.34	1.95K	12.33K	97.04K
Aug 16, 2023	PARLAVECCHIO CARYN	SALE	6.83	1.35K	9.24K	117.2K
Apr 28, 2023	INVUS PUBLIC EQUITIES, L.P.	PURCHASE	6.43	31.56K	202.85K	9.06M
Jan 09, 2023	INVUS PUBLIC EQUITIES, L.P.	SALE	9.48	1.09K	10.37K	9.03M
Jan 05, 2023	INVUS PUBLIC EQUITIES, L.P.	PURCHASE	9.33	48.77K	455.09K	9.03M
Oct 25, 2022	INVUS PUBLIC EQUITIES, L.P.	PURCHASE	8.04	130.27K	1.05M	8.98M
Oct 04, 2022	INVUS PUBLIC EQUITIES, L.P.	PURCHASE	7.89	66K	520.76K	8.85M
Oct 04, 2022	INVUS PUBLIC EQUITIES ADVISORS, LLC	PURCHASE	7.89	66K	520.76K	8.85M
Oct 03, 2022	INVUS PUBLIC EQUITIES ADVISORS, LLC	PURCHASE	7.03	33.97K	238.79K	8.78M
Oct 03, 2022	INVUS PUBLIC EQUITIES, L.P.	PURCHASE	7.03	33.97K	238.79K	8.78M
Jun 22, 2022	NASHAT AMIR	PURCHASE	7.35	16.54K	121.54K	16.54K
Nov 15, 2021	MYLES EDWARD H	SALE	35.05	4.88K	171.01K	24.15K
Nov 12, 2021	MYLES EDWARD H	SALE	35.12	49.85K	1.75M	24.15K
Nov 11, 2021	MYLES EDWARD H	SALE	35.20	23.57K	829.86K	24.15K
Oct 01, 2021	FLIER JEFFREY S.	SALE	30.89	6K	185.33K	22.27K
Sep 20, 2021	FLIER JEFFREY S.	SALE	34.09	500	17.05K	9.01K
Jul 26, 2021	FLIER JEFFREY S.	SALE	31.48	3.04K	95.61K	28.27K
Mar 15, 2021	GILMAN MICHAEL	SALE	65.59	4.7K	308K	37.46K
Feb 08, 2021	GILMAN MICHAEL	SALE	65.06	1.8K	117.36K	42.16K
Jan 27, 2021	CARVEN GREGORY JOHN	SALE	57.79	1.56K	90.21K	26.86K
Jan 26, 2021	CARVEN GREGORY JOHN	SALE	61.52	1.06K	65.45K	45.96K
Jan 26, 2021	GILMAN MICHAEL	SALE	59.90	1.52K	90.93K	43.96K
May 29, 2018	SPRINGER TIMOTHY A	PURCHASE	14.00	71.43K	999.99K	3.27M
May 29, 2018	ARTAL INTERNATIONAL S.C.A.	PURCHASE	14.00	450K	6.3M	450K
May 29, 2018	NASHAT AMIR	PURCHASE	14.00	7.89K	110.42K	156.4K
May 29, 2018	POLARIS VENTURE MANAGEMENT CO. VI, L.L.C.	PURCHASE	14.00	7.89K	110.42K	156.4K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE42.22K3

SALES270.03K11

NET SHARES-227.81K8

SHARES HELD4.9M14

% NET SHARES-104.65%-42.86%

Frequently Asked Questions