How many institutions own SLNO stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own SLNO shares is 336, representing 124.97% of the company's common stock.

Who are the major shareholders selling Soleno Therapeutics, Inc. stock?

SEI INVESTMENTS CO, in the last quarter, reduced its stake in SLNO by -40.85% restricting it's holding to 67.33 thousand shares of worth nearly $3.12M. EMERALD ADVISERS, LLC also lessened -34.27% of the SLNO shares from its portfolio, reducing its holding to 412.65 thousand shares of worth $19.11M. BANK OF NEW YORK MELLON CORP also shunned SLNO shares holding by -0.86% last quarter which brought its holding to 621.81 thousand shares worth $28.79M.

Investors who are buying SLNO stock?

As per its latest 13F filing, NUVEEN, LLC increased its stake in SLNO by 6.34% in the last quarter. The institutional holder raised its holding to 100.62 thousand shares having worth more than $4.66M. RAFFERTY ASSET MANAGEMENT, LLC also added 3.38% more shares of SLNO to its portfolio, raising its holding to 95.6 thousand shares of worth $4.43M. SWISS NATIONAL BANK also increased its SLNO shares holding by 16.17% which brought its holding to 89.1 thousand shares worth $4.13M.

SLNO's major insiders: who are they?

The insider with the most stakes in SLNO is Vivo Opportunity, LLC , 10 percent owner at the company. Additionally, SLNO stock is highly held by 10 percent owner Carlyle Group Inc. and CHIEF EXECUTIVE OFFICER Anish Bhatnagar among others.

Did an insider recently sell SLNO stock?

Company executives, directors, and other insiders own 1.84% percent of Soleno Therapeutics, Inc.'s stock. Within the last six months, there have been 0 transaction(s) in which SLNO insiders have sold stock, totaling 0 shares. Insiders that have sold shares include HIRANO PATRICIA C, PAULS MATTHEW, and VIVO OPPORTUNITY, LLC.

Which insider recently purchased SLNO stock?

There have been 0 transaction(s) during the past 6-months in which Soleno Therapeutics, Inc. insiders have bought stock, totalling 0 shares

How much of SLNO does insiders own?

Around 0 Soleno Therapeutics, Inc. shares are held by insiders, which represents about 1.84% of SLNO stock.

Who is the insider with the largest stake?

SLNO 10 percent owner, Vivo Opportunity, LLC holds the largest portfolio of the company's shares. SLNO shares owned by Vivo total nearly 4.46 million.

Which institution holds the most shares in SLNO?

NUVEEN, LLC is the largest institutional owner in SLNO which holds 100.62 thousand shares worth $4.66M or 0.19% of the total SLNO shares outstanding followed by RAFFERTY ASSET MANAGEMENT, LLC with ownership of 95.6 thousand shares representing 0.18% of the SLNO ownership. SWISS NATIONAL BANK is the third largest stakeholder with 89.1 thousand shares or 0.17% of the ownership worth more than $4.13M.

Is Soleno Therapeutics, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the SLNO is concerned, it is a stock which is optionable.

Is there a short position on SLNO's shares?

Number of SLNO shares short is 6.31M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding SLNO shares are there?

As of today, 53.15M shares of SLNO are outstanding.

Is there many float in SLNO stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, SLNO has 44.87M shares in float.

SLNO short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for SLNO is 4.15.

Soleno Therapeutics (SLNO) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares11.87

Short Percent Of Float13.55

Shares Outstanding53.15M

Shares Float44.87M

Shares Short6.31M

Short Ratio4.15

13.55%

Short % of Float

11.87%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

1.84% Percentage of Shares held by All Insiders

124.97% Percentage of Shares held by All Institutions

127.32% Percentage of Float held by Institutions

336

Number of Institutions Holding Shares

Institutional Ownership

About 124.97% of SLNO shares are held by financial institutions. NUVEEN, LLC is the top corporate investor, holding 100.62K shares valued at $4.66M. A 0.19% stake in Soleno Therapeutics, Inc. is owned by the company. RAFFERTY ASSET MANAGEMENT, LLC owns 95.6K shares valued at $4.43M, which translates its holding of 0.18% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	NUVEEN, LLC	0.19%	100.62K	4.66M	6K	+6.34%
Dec 31, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.18%	95.6K	4.43M	3.12K	+3.38%
Dec 31, 2025	SWISS NATIONAL BANK	0.17%	89.1K	4.13M	12.4K	+16.17%
Dec 31, 2025	MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	0.16%	83.17K	3.85M	4.33K	+5.50%
Dec 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.14%	72.36K	3.35M	13.97K	+23.92%
Dec 31, 2025	HEALTHINVEST PARTNERS AB	0.12%	62.74K	2.9M	2.58K	+4.29%
Dec 31, 2025	SEI INVESTMENTS CO	0.13%	67.33K	3.12M	-46.5K	-40.85%
Dec 31, 2025	STATE STREET CORP	4.97%	2.65M	122.68M	476.59K	+21.93%
Dec 31, 2025	VANGUARD GROUP INC	5.74%	3.06M	141.69M	253.21K	+9.02%
Dec 31, 2025	BLACKROCK, INC.	7.26%	3.87M	179.26M	379.39K	+10.86%
Dec 31, 2025	EMERALD ADVISERS, LLC	0.77%	412.65K	19.11M	-215.11K	-34.27%
Dec 31, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.84%	449.85K	20.82M	169.55K	+60.49%
Dec 31, 2025	SQUAREPOINT OPS LLC	0.88%	468.65K	21.7M	399.7K	+579.66%
Dec 31, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	0.94%	502K	23.24M	402K	+402.00%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	1.17%	621.81K	28.79M	-5.42K	-0.86%
Dec 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.17%	624.13K	28.9M	73.5K	+13.35%
Dec 31, 2025	VIVO CAPITAL, LLC	1.68%	894.91K	41.43M	-1.38M	-60.72%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	1.71%	913.05K	42.27M	357.61K	+64.38%
Dec 31, 2025	DEEP TRACK CAPITAL, LP	1.88%	1M	46.3M	1M	+100.00%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.18%	1.16M	53.87M	78.39K	+7.22%
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	2.32%	1.24M	57.24M	256.5K	+26.18%
Dec 31, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.46%	247.05K	11.44M	92.53K	+59.88%
Dec 31, 2025	INTEGRAL HEALTH ASSET MANAGEMENT, LLC	0.61%	325K	15.05M	325K	+100.00%
Dec 31, 2025	CAPTION MANAGEMENT, LLC	0.64%	342.5K	15.86M	-673.6K	-66.29%
Dec 31, 2025	CATALIO CAPITAL MANAGEMENT, LP	0.68%	360.34K	16.68M	-57.91K	-13.84%
Dec 31, 2025	GREAT POINT PARTNERS LLC	0.75%	400K	18.52M	175K	+77.78%
Dec 31, 2025	IKARIAN CAPITAL, LLC	0.99%	528.9K	24.49M	352.8K	+200.34%
Dec 31, 2025	ARTIA GLOBAL PARTNERS LP	1%	533.7K	24.71M	-138.48K	-20.60%
Dec 31, 2025	HOOD RIVER CAPITAL MANAGEMENT LLC	1.16%	618.01K	28.61M	4.61K	+0.75%
Dec 31, 2025	READYSTATE ASSET MANAGEMENT LP	1.64%	874.45K	40.49M	668.64K	+324.89%
Dec 31, 2025	WOODLINE PARTNERS LP	2.08%	1.11M	51.48M	840.95K	+310.50%
Dec 31, 2025	BRAIDWELL LP	2.23%	1.19M	55M	-94.13K	-7.34%
Dec 31, 2025	COMMODORE CAPITAL LP	2.25%	1.2M	55.56M	-150K	-11.11%
Dec 31, 2025	AVORO CAPITAL ADVISORS LLC	5.44%	2.9M	134.27M	322.22K	+12.50%
Dec 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	6.22%	3.32M	153.66M	-584.21K	-14.97%
Dec 31, 2025	JANUS HENDERSON GROUP PLC	13.46%	7.18M	332.3M	1.12M	+18.53%
Dec 31, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.2%	105.6K	4.89M	-154.4K	-59.38%
Dec 31, 2025	JPMORGAN CHASE & CO	0.22%	115.52K	5.35M	-291.93K	-71.65%
Dec 31, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.22%	117.49K	5.44M	117.49K	+100.00%
Dec 31, 2025	CENTIVA CAPITAL, LP	0.22%	118.8K	5.5M	118.8K	+100.00%
Dec 31, 2025	JEFFERIES FINANCIAL GROUP INC.	0.22%	119.2K	5.52M	119.2K	+100.00%
Dec 31, 2025	PEREGRINE CAPITAL MANAGEMENT LLC	0.22%	119.56K	5.54M	26.56K	+28.56%
Dec 31, 2025	NAN FUNG TRINITY (HK) LTD	0.23%	123.85K	5.73M	0	0
Dec 31, 2025	ROYCE & ASSOCIATES LP	0.24%	129.04K	5.97M	98.06K	+316.44%
Dec 31, 2025	EAGLE HEALTH INVESTMENTS LP	0.25%	135.1K	6.26M	135.1K	+100.00%
Dec 31, 2025	JANE STREET GROUP, LLC	0.27%	141.74K	6.56B	141.74K	+100.00%
Dec 31, 2025	DEUTSCHE BANK AG\	0.27%	141.98K	6.57M	5.21K	+3.81%
Dec 31, 2025	CAPITAL WORLD INVESTORS	0.27%	145.52K	6.74M	-678.99K	-82.35%
Dec 31, 2025	BARCLAYS PLC	0.3%	157.69K	7.3M	-13.3K	-7.78%
Dec 31, 2025	UBS GROUP AG	0.32%	169.51K	7.85M	11.2K	+7.07%
Dec 31, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.35%	185.32K	8.58M	169.72K	+1,087.93%
Dec 31, 2025	SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)	0.35%	187.48K	8.68M	64.74K	+52.74%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	0.39%	208.6K	9.66B	46.5K	+28.68%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.4%	212.82K	9.85M	204.71K	+2,524.79%
Dec 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.41%	217.5K	10.07M	25K	+12.99%
Dec 31, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.44%	232.49K	10.76M	-147.42K	-38.80%
Dec 31, 2025	PFM HEALTH SCIENCES, LP	0.46%	247.89K	11.48M	4.49K	+1.85%
Dec 31, 2025	PENN CAPITAL MANAGEMENT COMPANY, LLC	0.52%	275.78K	12.8M	275.78K	+100.00%
Dec 31, 2025	LOGOS GLOBAL MANAGEMENT LP	0.56%	300K	13.89M	300K	+100.00%
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.46%	244.36K	11.31M	228.34K	+1,425.52%
Dec 31, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.72%	384.17K	17.79M	384.17K	+100.00%
Dec 31, 2025	KINGDON CAPITAL MANAGEMENT, L.L.C.	0.75%	399.9K	18.52M	98.9K	+32.86%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.75%	401.19K	18.57M	11.83K	+3.04%
Dec 31, 2025	RHUMBLINE ADVISERS	0.1%	55.07K	2.55M	-4.79K	-8.01%
Dec 31, 2025	FMR LLC	15.15%	8.08M	374.07M	79.62K	+1.00%
Dec 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	6.23%	3.32M	153.85M	1.01M	+43.71%
Dec 31, 2025	POLAR CAPITAL HOLDINGS PLC	2.13%	1.14M	52.64M	-54.19K	-4.55%
Dec 31, 2025	INVESCO LTD.	1.64%	875.02K	40.51M	-625.51K	-41.69%
Dec 31, 2025	NORTHERN TRUST CORP	0.69%	365.42K	16.92M	11.18K	+3.16%
Dec 31, 2025	CITADEL ADVISORS LLC	0.58%	308.83K	14.3M	-141.3K	-31.39%
Dec 31, 2025	ABRDN PLC	0.54%	287.46K	13.31M	287.46K	+100.00%
Dec 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.54%	287.29K	13.3M	221.52K	+336.80%
Dec 31, 2025	CITIGROUP INC	0.48%	255.4K	11.83M	223.9K	+710.79%
Dec 31, 2025	FRANKLIN RESOURCES INC	1.55%	823.96K	38.15M	-11.79K	-1.41%
Dec 31, 2025	MORGAN STANLEY	0.54%	287.64K	13.32M	121.79K	+73.44%
Sep 30, 2025	HSBC HOLDINGS PLC	0.25%	123.95K	8.38M	120.05K	+3,075.79%
Sep 30, 2025	DEUTSCHE BANK AG\	0.27%	136.78K	9.25M	9.44K	+7.42%
Sep 30, 2025	UBS GROUP AG	0.31%	158.31K	10.7M	52.31K	+49.35%
Sep 30, 2025	BARCLAYS PLC	0.1%	50K	3.38M	50K	+100.00%
Sep 30, 2025	WOODLINE PARTNERS LP	0.54%	270.83K	18.31M	-78.83K	-22.55%
Sep 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.56%	280.3K	19.1M	263.36K	+1,554.93%
Sep 30, 2025	KINGDON CAPITAL MANAGEMENT, L.L.C.	0.6%	301K	20.35M	301K	+100.00%
Sep 30, 2025	ALLY BRIDGE GROUP (NY) LLC	0.6%	302.48K	20.45M	123.66K	+69.16%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	4.58%	2.31M	156.3M	1.69M	+272.30%
Sep 30, 2025	JENNISON ASSOCIATES LLC	0.65%	349.07K	23.6M	349.07K	+100.00%
Sep 30, 2025	NORTHERN TRUST CORP	0.7%	354.23K	23.95M	25.59K	+7.79%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	1.31%	660.57K	44.65M	298.96K	+82.68%
Sep 30, 2025	EMERALD ADVISERS, LLC	1.18%	627.76K	42.44M	-45.15K	-6.71%
Sep 30, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.71%	379.9K	25.68M	-25.75K	-6.35%
Sep 30, 2025	CAPTION MANAGEMENT, LLC	0.73%	370K	25.01M	106.71K	+40.53%
Sep 30, 2025	TIMESSQUARE CAPITAL MANAGEMENT, LLC	0.75%	377.57K	25.52M	130.2K	+52.63%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.77%	389.36K	26.32M	93.09K	+31.42%
Sep 30, 2025	CATALIO CAPITAL MANAGEMENT, LP	0.83%	418.25K	28.27M	8.3K	+2.02%
Sep 30, 2025	TRI LOCUM PARTNERS LP	0.89%	450.59K	30.46M	161.71K	+55.98%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.15%	1.08M	73.36M	182.56K	+20.23%
Sep 30, 2025	INVESCO LTD.	2.97%	1.5M	101.44M	854.55K	+132.29%
Sep 30, 2025	STATE STREET CORP	4.3%	2.17M	146.9M	768.05K	+54.67%
Sep 30, 2025	VIVO CAPITAL, LLC	4.51%	2.28M	154.01M	-1.68M	-42.44%
Sep 30, 2025	AVORO CAPITAL ADVISORS LLC	5.11%	2.58M	174.26M	527.78K	+25.75%
Sep 30, 2025	JANUS HENDERSON GROUP PLC	12%	6.06M	409.5M	748.33K	+14.10%
Sep 30, 2025	FMR LLC	15.85%	8M	540.78M	4.66M	+139.67%
Sep 30, 2025	MARSHALL WACE, LLP	0.36%	184.23K	12.45M	-104.11K	-36.11%
Sep 30, 2025	CITADEL ADVISORS LLC	0.89%	450.13K	30.43M	-1.06M	-70.09%
Sep 30, 2025	AFFINITY ASSET ADVISORS, LLC	0.4%	200K	13.52M	200K	+100.00%
Sep 30, 2025	SAMLYN CAPITAL, LLC	0.92%	466.18K	31.51M	226.05K	+94.14%
Sep 30, 2025	HOOD RIVER CAPITAL MANAGEMENT LLC	1.22%	613.39K	41.47M	613.39K	+100.00%
Sep 30, 2025	SIREN, L.L.C.	0.93%	467.34K	31.59M	0	0
Sep 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	0.93%	467.44K	31.6M	467.44K	+100.00%
Sep 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.09%	550.62K	37.22M	-101.43K	-15.56%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	1.18%	627.23K	42.4M	141.36K	+29.09%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.1%	555.44K	37.55M	210.47K	+61.01%
Sep 30, 2025	WESTFIELD CAPITAL MANAGEMENT CO LP	1.78%	899.16K	60.78M	-530.6K	-37.11%
Sep 30, 2025	VANGUARD GROUP INC	5.56%	2.81M	189.76M	319.32K	+12.84%
Sep 30, 2025	BLACKROCK, INC.	6.92%	3.49M	236.08M	647.51K	+22.76%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	7.73%	3.9M	263.84M	441.42K	+12.75%
Sep 30, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.52%	260K	17.58M	10K	+4.00%
Sep 30, 2025	PFM HEALTH SCIENCES, LP	0.48%	243.4K	16.45M	-163.8K	-40.23%
Sep 30, 2025	GREAT POINT PARTNERS LLC	0.45%	225K	15.21M	225K	+100.00%
Sep 30, 2025	ENSIGN PEAK ADVISORS, INC	0.41%	208.51K	14.1M	89.27K	+74.86%
Sep 30, 2025	READYSTATE ASSET MANAGEMENT LP	0.41%	205.81K	13.91M	-187K	-47.61%
Sep 30, 2025	ALLSPRING GLOBAL INVESTMENTS HOLDINGS, LLC	0.53%	280.98K	16.89M	201.98K	+255.67%
Sep 30, 2025	ARTIA GLOBAL PARTNERS LP	1.33%	672.18K	45.44M	177.75K	+35.95%
Sep 30, 2025	CAPITAL WORLD INVESTORS	1.63%	824.51K	55.74M	209.68K	+34.10%
Sep 30, 2025	FRANKLIN RESOURCES INC	1.66%	835.75K	56.5M	649.35K	+348.36%
Sep 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	1.71%	863.76K	58.39M	-137.59K	-13.74%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	1.94%	979.83K	66.24M	346.11K	+54.61%
Sep 30, 2025	HOLOCENE ADVISORS, LP	1.98%	997.07K	67.4M	-155.98K	-13.53%
Sep 30, 2025	POLAR CAPITAL HOLDINGS PLC	2.36%	1.19M	80.52M	373.62K	+45.70%
Sep 30, 2025	BRAIDWELL LP	2.54%	1.28M	86.66M	1.28M	+100.00%
Sep 30, 2025	COMMODORE CAPITAL LP	2.67%	1.35M	91.26M	740K	+121.31%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	2.78%	1.4M	94.75M	-2.17M	-60.81%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.8%	401.7K	27.15M	6.8K	+1.72%
Sep 30, 2025	JPMORGAN CHASE & CO	0.81%	407.44K	27.54M	148.48K	+57.34%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.08%	39.94K	2.7M	4.54K	+12.81%
Sep 30, 2025	PERSISTENT ASSET PARTNERS LTD	0.08%	41.26K	2.79M	-24.06K	-36.83%
Sep 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.08%	41.53K	2.81M	32.37K	+353.70%
Sep 30, 2025	EISLER CAPITAL MANAGEMENT LTD.	0.09%	44.6K	2.99M	44.6K	+100.00%
Sep 30, 2025	MOODY ALDRICH PARTNERS LLC	0.1%	51.27K	3.47M	9.76K	+23.50%
Sep 30, 2025	F/M INVESTMENTS LLC	0.11%	55.73K	3.77M	16.19K	+40.94%
Sep 30, 2025	HEALTHINVEST PARTNERS AB	0.11%	60.16K	431.72K	19.62K	+48.42%
Sep 30, 2025	RHUMBLINE ADVISERS	0.12%	59.86K	4.05M	814	+1.38%
Sep 30, 2025	LORD, ABBETT & CO. LLC	0.12%	60.74K	4.11M	-75.76K	-55.50%
Sep 30, 2025	CENTERBOOK PARTNERS LP	0.12%	62.79K	4.24M	38.28K	+156.18%
Sep 30, 2025	JEFFERIES FINANCIAL GROUP INC.	0.15%	74.2K	5.02M	0	0
Sep 30, 2025	MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	0.15%	78.83K	5.33M	579	+0.74%
Sep 30, 2025	SWISS NATIONAL BANK	0.15%	76.7K	5.18M	14.4K	+23.11%
Sep 30, 2025	PEREGRINE CAPITAL MANAGEMENT LLC	0.17%	93.01K	6.29M	93.01K	+100.00%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.18%	92.48K	6.25M	45.08K	+95.10%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.19%	94.34K	6.38M	11.39K	+13.73%
Sep 30, 2025	NUVEEN, LLC	0.19%	94.63K	6.4M	-109.24K	-53.58%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.23%	113.75K	7.69M	13.94K	+13.97%
Sep 30, 2025	SEI INVESTMENTS CO	0.23%	113.83K	7.7M	81.09K	+247.67%
Sep 30, 2025	NAN FUNG TRINITY (HK) LTD	0.23%	123.85K	8.37M	20.9K	+20.30%
Sep 30, 2025	SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)	0.24%	122.74K	8.3M	93.54K	+320.30%
Jun 30, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.8%	405.65K	33.99M	33.95K	+9.13%
Jun 30, 2025	ARTIA GLOBAL PARTNERS LP	0.98%	494.42K	41.42M	-4.05K	-0.81%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.96%	485.87K	40.71M	183.2K	+60.53%
Jun 30, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.88%	445.35K	37.31M	-83.86K	-15.85%
Jun 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.76%	384.27K	32.19M	136.54K	+55.11%
Jun 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.72%	361.61K	30.3M	344.27K	+1,986.34%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.59%	296.26K	24.82M	82.28K	+38.45%
Jun 30, 2025	WOODLINE PARTNERS LP	0.69%	349.66K	29.29M	0	0
Jun 30, 2025	NORTHERN TRUST CORP	0.65%	328.64K	27.53M	96.3K	+41.45%
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.78%	394.9K	33.08M	-526.4K	-57.14%
Jun 30, 2025	TRI LOCUM PARTNERS LP	0.57%	288.88K	24.2M	53.96K	+22.97%
Jun 30, 2025	MARSHALL WACE, LLP	0.57%	288.33K	24.16M	164.58K	+132.99%
Jun 30, 2025		0.56%	284.15K	23.81M	191.15K	+205.53%
Jun 30, 2025	CAPTION MANAGEMENT, LLC	1.12%	565.8K	47.4M	393.7K	+228.76%
Jun 30, 2025	JPMORGAN CHASE & CO	0.51%	258.97K	21.7M	231.58K	+845.61%
Jun 30, 2025	VIVO CAPITAL, LLC	7.84%	3.96M	331.63M	-500K	-11.22%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	7.08%	3.58M	299.59M	-816.73K	-18.59%
Jun 30, 2025	FMR LLC	6.61%	3.34M	279.65M	1.1M	+49.45%
Jun 30, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.5%	250.44K	20.98M	-184.07K	-42.36%
Jun 30, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.5%	250K	20.95M	225K	+900.00%
Jun 30, 2025	TIMESSQUARE CAPITAL MANAGEMENT, LLC	0.49%	247.37K	20.72M	40.77K	+19.73%
Jun 30, 2025	SAMLYN CAPITAL, LLC	0.48%	240.13K	20.12M	49.25K	+25.80%
Jun 30, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.41%	204.59K	17.14M	38.17K	+22.94%
Jun 30, 2025	IKARIAN CAPITAL, LLC	0.4%	200K	16.76M	-43K	-17.70%
Jun 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	0.37%	186.25K	15.6M	-88.75K	-32.27%
Jun 30, 2025	ALLY BRIDGE GROUP (NY) LLC	0.35%	178.82K	14.98M	58.37K	+48.46%
Jun 30, 2025	ROCK SPRINGS CAPITAL MANAGEMENT LP	0.31%	154.53K	12.95M	30.43K	+24.52%
Jun 30, 2025	LORD, ABBETT & CO. LLC	0.27%	136.51K	11.44M	81.45K	+147.92%
Jun 30, 2025	ZIMMER PARTNERS, LP	0.24%	120.6K	10.1M	120.6K	+100.00%
Jun 30, 2025	ATIKA CAPITAL MANAGEMENT LLC	0.24%	120.5K	10.1M	19.9K	+19.78%
Jun 30, 2025	ENSIGN PEAK ADVISORS, INC	0.24%	119.25K	9.99M	38.18K	+47.10%
Jun 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.23%	116.87K	9.79M	-106.41K	-47.66%
Jun 30, 2025	BLACKROCK, INC.	5.64%	2.84M	238.33M	931.42K	+48.68%
Jun 30, 2025	AVORO CAPITAL ADVISORS LLC	4.06%	2.05M	171.75M	-475K	-18.81%
Jun 30, 2025	INVESCO LTD.	1.28%	645.97K	54.12M	178.78K	+38.27%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	1.26%	633.72K	53.09M	-45.57K	-6.71%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	1.23%	621.04K	52.03M	-72.61K	-10.47%
Jun 30, 2025	CAPITAL WORLD INVESTORS	1.22%	614.83K	51.51M	150K	+32.27%
Jun 30, 2025	COMMODORE CAPITAL LP	1.21%	610K	51.11M	-540K	-46.96%
Jun 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	1.16%	583.4K	48.88M	505.5K	+648.91%
Jun 30, 2025	NATIONALE-NEDERLANDEN POWSZECHNE TOWARZYSTWO EMERYTALNE S.A.	1%	502.37K	42.09M	502.37K	+100.00%
Jun 30, 2025	SIREN, L.L.C.	0.93%	467.34K	39.15M	-260K	-35.75%
Jun 30, 2025	JANUS HENDERSON GROUP PLC	10.51%	5.31M	444.59M	167.11K	+3.25%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	6.86%	3.46M	290M	1.06M	+44.20%
Jun 30, 2025	VANGUARD GROUP INC	4.93%	2.49M	208.43M	621.51K	+33.30%
Jun 30, 2025	CITADEL ADVISORS LLC	2.98%	1.51M	126.1M	-70.88K	-4.50%
Jun 30, 2025	WESTFIELD CAPITAL MANAGEMENT CO LP	2.83%	1.43M	119.78M	218.51K	+18.04%
Jun 30, 2025	STATE STREET CORP	2.78%	1.4M	117.71M	235.78K	+20.17%
Jun 30, 2025	HOLOCENE ADVISORS, LP	2.28%	1.15M	96.6M	-43.94K	-3.67%
Jun 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	1.98%	1M	83.89M	-755.67K	-43.01%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.79%	902.4K	75.61M	286.66K	+46.56%
Jun 30, 2025	CARLYLE GROUP INC.	1.71%	860.98K	72.08M	0	0
Jun 30, 2025	POLAR CAPITAL HOLDINGS PLC	1.62%	817.5K	68.49M	317.5K	+63.50%
Jun 30, 2025	EMERALD ADVISERS, LLC	1.33%	672.91K	56.38M	108.43K	+19.21%
Jun 30, 2025	MORGAN STANLEY	0.87%	440.05K	36.87M	227.7K	+107.22%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.68%	344.97K	28.9M	-288.14K	-45.51%
Jun 30, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.29%	652.05K	54.63M	-185.78K	-22.17%
Jun 30, 2025	PERCEPTIVE ADVISORS LLC	0.85%	430.44K	36.06M	-1.08M	-71.43%
Jun 30, 2025	RTW INVESTMENTS, LP	0.84%	424.41K	35.56M	424.41K	+100.00%
Jun 30, 2025	SOFINNOVA INVESTMENTS, INC.	0.82%	415.22K	34.79M	-69.25K	-14.29%
Jun 30, 2025	PFM HEALTH SCIENCES, LP	0.81%	407.2K	34.12M	-188K	-31.59%
Jun 30, 2025	READYSTATE ASSET MANAGEMENT LP	0.78%	392.81K	32.91M	293.39K	+295.09%
Jun 30, 2025	CATALIO CAPITAL MANAGEMENT, LP	0.81%	409.94K	34.35M	248.98K	+154.68%
Jun 30, 2025	DIADEMA PARTNERS LP	0.56%	284.15K	23.81M	191.15K	+205.53%
Mar 31, 2025	EMERALD ADVISERS, LLC	1.22%	564.48K	40.33M	-16.44K	-2.83%
Mar 31, 2025	PFM HEALTH SCIENCES, LP	1.29%	595.21K	42.53M	287.7K	+93.56%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.33%	615.74K	44M	16.62K	+2.77%
Mar 31, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.94%	434.51K	31.05M	434.51K	+100.00%
Mar 31, 2025	POLAR CAPITAL HOLDINGS PLC	1.08%	500K	35.73M	500K	+100.00%
Mar 31, 2025	SOFINNOVA INVESTMENTS, INC.	1.05%	484.47K	34.62M	-272.78K	-36.02%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	1.5%	693.64K	49.56M	-88.62K	-11.33%
Mar 31, 2025	IKARIAN CAPITAL, LLC	0.53%	243K	17.36M	243K	+100.00%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	1.37%	633.11K	45.24M	213.67K	+50.94%
Mar 31, 2025	SIREN, L.L.C.	1.58%	727.34K	51.97M	375.52K	+106.74%
Mar 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	1.98%	916K	65.45M	916K	+100.00%
Mar 31, 2025	CITADEL ADVISORS LLC	0.96%	441.9K	31.57M	302.3K	+216.55%
Mar 31, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	1.3%	600K	42.87M	600K	+100.00%
Mar 31, 2025	WESTFIELD CAPITAL MANAGEMENT CO LP	2.62%	1.21M	86.54M	329.79K	+37.41%
Mar 31, 2025	COMMODORE CAPITAL LP	2.49%	1.15M	82.17M	-375K	-24.59%
Mar 31, 2025	SOROS FUND MANAGEMENT LLC	0.59%	270.66K	19.34M	270.66K	+100.00%
Mar 31, 2025	PERCEPTIVE ADVISORS LLC	3.26%	1.51M	107.65M	5.56K	+0.37%
Mar 31, 2025	VANGUARD GROUP INC	4.04%	1.87M	133.35M	-18.21K	-0.97%
Mar 31, 2025	BLACKROCK, INC.	4.14%	1.91M	136.71M	-96.46K	-4.80%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	5.2%	2.4M	171.51M	769.7K	+47.20%
Mar 31, 2025	AVORO CAPITAL ADVISORS LLC	5.47%	2.53M	180.41M	0	0
Mar 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	9.51%	4.39M	313.86M	1.62M	+58.24%
Mar 31, 2025	VIVO CAPITAL, LLC	9.65%	4.46M	318.55M	-1.83M	-29.14%
Mar 31, 2025	JANUS HENDERSON GROUP PLC	11.13%	5.14M	370.02M	-47.37K	-0.91%
Mar 31, 2025	STATE STREET CORP	2.53%	1.17M	83.54M	-177.82K	-13.20%
Mar 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.54%	247.74K	17.7M	247.74K	+100.00%
Mar 31, 2025	TCG CROSSOVER MANAGEMENT, LLC	0.6%	275K	19.65M	-275K	-50.00%
Mar 31, 2025	KYNAM CAPITAL MANAGEMENT, LP	0.66%	302.5K	21.61M	302.5K	+100.00%
Mar 31, 2025	WOODLINE PARTNERS LP	0.76%	349.66K	24.98M	48.1K	+15.95%
Mar 31, 2025	CAPTION MANAGEMENT, LLC	0.64%	295K	21.08M	271.85K	+1,174.41%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.66%	302.66K	21.63M	234.65K	+345.00%
Mar 31, 2025	INVESCO LTD.	1.01%	467.19K	33.38M	455.18K	+3,789.39%
Mar 31, 2025	ARTIA GLOBAL PARTNERS LP	1.08%	498.47K	35.62M	4.05K	+0.82%
Mar 31, 2025	EMERALD MUTUAL FUND ADVISERS TRUST	0.8%	371.7K	26.56M	3.12K	+0.85%
Mar 31, 2025	HOLOCENE ADVISORS, LP	2.59%	1.2M	85.52M	241.52K	+25.28%
Mar 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.81%	837.84K	59.86M	-14K	-1.64%
Mar 31, 2025	CARLYLE GROUP INC.	1.86%	860.98K	61.45M	-514.67K	-37.41%
Mar 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	1.15%	529.21K	37.81M	105.13K	+24.79%
Mar 31, 2025	FMR LLC	4.84%	2.23M	159.58M	1.42M	+174.71%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.74%	341.8K	24.42M	336.8K	+6,736.00%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.67%	307.1K	21.94M	-1.2M	-79.68%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.93%	430.06K	30.73M	380.11K	+761.00%
Mar 31, 2025	CAPITAL WORLD INVESTORS	1.01%	464.83K	33.21M	464.83K	+100.00%
Mar 31, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	1.08%	499.16K	35.66M	-200K	-28.61%
Mar 31, 2024	IKARIAN CAPITAL, LLC	0.22%	81.1K	3.47M	59.9K	+282.55%
Mar 31, 2024	POLYMER CAPITAL MANAGEMENT (HK) LTD	0.02%	6.91K	295.92K	6.91K	+100.00%
Mar 31, 2024	PICTET ASSET MANAGEMENT HOLDING SA	0.92%	333.85K	14.29M	333.85K	+100.00%
Mar 31, 2024	ALLY BRIDGE GROUP (NY) LLC	0.93%	336.49K	14.4M	26.54K	+8.56%
Mar 31, 2024	TCG CROSSOVER MANAGEMENT, LLC	1.52%	550K	23.54M	550K	+100.00%
Mar 31, 2024	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	2.42%	875.67K	37.48M	410.73K	+88.34%
Mar 31, 2024	VESTAL POINT CAPITAL, LP	3.45%	1.25M	53.5M	-50K	-3.85%
Mar 31, 2024	AVORO CAPITAL ADVISORS LLC	4.49%	1.63M	69.55M	840K	+107.01%
Mar 31, 2024	VIVO CAPITAL, LLC	23.25%	8.42M	360.29M	0	0
Mar 31, 2024	HIGHVISTA STRATEGIES LLC	0.03%	10.43K	446.32K	10.43K	+100.00%
Mar 31, 2024	STATE OF WISCONSIN INVESTMENT BOARD	0.03%	11.13K	476.19K	1.63K	+17.17%
Mar 31, 2024	CANNON GLOBAL INVESTMENT MANAGEMENT, LLC	0.03%	11.8K	505.04K	11.8K	+100.00%
Mar 31, 2024	ASPIRIANT, LLC	0.03%	12.13K	519.08K	0	0
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.03%	12.28K	525.71K	4.56K	+58.96%
Mar 31, 2024	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.04%	14.21K	608K	14.21K	+100.00%
Mar 31, 2024	SQUAREPOINT OPS LLC	0.04%	14.58K	624.02K	7.67K	+111.03%
Mar 31, 2024	TUDOR INVESTMENT CORP ET AL	0.04%	16.19K	693.1K	16.19K	+100.00%
Mar 31, 2024	ALPS ADVISORS INC	0.06%	21.51K	920.8K	2.03K	+10.41%
Mar 31, 2024	MAPLELANE CAPITAL, LLC	0.07%	25K	1.07M	0	0
Mar 31, 2024	FARALLON CAPITAL MANAGEMENT LLC	0.08%	27.75K	1.19M	-137.47K	-83.20%
Mar 31, 2024	JEFFERIES FINANCIAL GROUP INC.	0.1%	35.89K	1.54M	800	+2.28%
Mar 31, 2024	ARTIA GLOBAL PARTNERS LP	0.11%	40.92K	1.75M	40.92K	+100.00%
Mar 31, 2024	SCHONFELD STRATEGIC ADVISORS LLC	0.13%	45.47K	1.95M	-15.42K	-25.32%
Mar 31, 2024	CAPTION MANAGEMENT, LLC	0.11%	40K	1.71M	40K	+100.00%
Mar 31, 2024	EAM INVESTORS, LLC	0.18%	64.41K	2.76M	-29.01K	-31.06%
Mar 31, 2024	683 CAPITAL MANAGEMENT, LLC	0.22%	78K	3.34M	-9K	-10.34%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.22%	78.5K	3.36M	59.8K	+319.88%
Mar 31, 2024	SOROS FUND MANAGEMENT LLC	0.28%	100K	4.28M	100K	+100.00%
Mar 31, 2024	ALLSPRING GLOBAL INVESTMENTS HOLDINGS, LLC	0.29%	103.84K	4.44M	103.84K	+100.00%
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	0.29%	106.14K	4.54M	54.27K	+104.62%
Mar 31, 2024	WOODLINE PARTNERS LP	0.29%	106.46K	4.56M	-93.54K	-46.77%
Mar 31, 2024	STEMPOINT CAPITAL LP	0.32%	115.83K	4.96M	115.83K	+100.00%
Mar 31, 2024	BOOTHBAY FUND MANAGEMENT, LLC	0.06%	21.6K	924.48K	16K	+285.71%
Mar 31, 2024	SOFINNOVA INVESTMENTS, INC.	0.42%	150.78K	6.45M	149.58K	+12,464.58%
Mar 31, 2024	BALYASNY ASSET MANAGEMENT L.P.	0.42%	151.62K	6.49M	-775.26K	-83.64%
Mar 31, 2024	ALTIUM CAPITAL MANAGEMENT LP	0.42%	152.91K	6.54M	48K	+45.75%
Mar 31, 2024	COMMODORE CAPITAL LP	0.47%	169.53K	7.26M	-530.47K	-75.78%
Mar 31, 2024	MARSHALL WACE, LLP	0.49%	176.24K	7.54M	176.24K	+100.00%
Mar 31, 2024	GHOST TREE CAPITAL, LLC	0.55%	200K	8.56M	87.62K	+77.96%
Mar 31, 2024	SAMLYN CAPITAL, LLC	0.6%	218.93K	9.37M	-82.85K	-27.45%
Mar 31, 2024	ADAGE CAPITAL PARTNERS GP, L.L.C.	5.37%	1.94M	83.18M	116.71K	+6.39%
Mar 31, 2024	NANTAHALA CAPITAL MANAGEMENT, LLC	6.66%	2.41M	103.16M	-445.97K	-15.61%
Mar 31, 2024	JANUS HENDERSON GROUP PLC	7.93%	2.87M	122.7M	346.91K	+13.75%
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.06%	21K	898.8K	21K	+100.00%
Mar 31, 2024	EMERALD MUTUAL FUND ADVISERS TRUST	0.64%	231.76K	9.92M	30.44K	+15.12%
Mar 31, 2024	EMERALD ADVISERS, LLC	0.83%	300.38K	12.86M	48.22K	+19.12%
Mar 31, 2024	PERCEPTIVE ADVISORS LLC	8.49%	3.07M	131.59M	0	0
Mar 31, 2024	CARLYLE GROUP INC.	11.24%	4.07M	173.12M	1.21M	+42.47%
Sep 30, 2022	AIGH CAPITAL MANAGEMENT LLC	0%	0	-	-6.36M	-100.00%
Sep 30, 2022	ONYX BRIDGE WEALTH GROUP LLC	0%	0	-	-20K	-100.00%
Sep 30, 2022	WORTH VENTURE PARTNERS, LLC	0%	0	-	-1.58M	-100.00%
Sep 30, 2022	ADVISOR GROUP HOLDINGS, INC.	0%	0	-	-1.12K	-100.00%
Sep 30, 2022	UBS GROUP AG	0%	0	-	-54.7K	-100.00%
Sep 30, 2022	GRANITE POINT CAPITAL MANAGEMENT, L.P.	0%	0	-	-2.65M	-100.00%
Sep 30, 2022	WARBERG ASSET MANAGEMENT LLC	0%	0	-	-90K	-100.00%
Sep 30, 2022	VIRTU FINANCIAL LLC	0%	0	-	-67.57K	-100.00%
Sep 30, 2022	TOWER RESEARCH CAPITAL LLC (TRC)	0%	0	-	-3.62K	-100.00%
Sep 30, 2022	TWO SIGMA ADVISERS, LP	0%	0	-	-232K	-100.00%
Sep 30, 2022	HRT FINANCIAL LP	0%	0	-	-47.73K	-100.00%
Sep 30, 2022	NANTAHALA CAPITAL MANAGEMENT, LLC	0%	0	-	-9.44M	-100.00%
Sep 30, 2022	TWO SIGMA SECURITIES, LLC	0%	0	-	-12.72K	-100.00%
Sep 30, 2022	ORACLE INVESTMENT MANAGEMENT INC	0%	0	-	-2.13M	-100.00%
Sep 30, 2022	AVANTAX PLANNING PARTNERS, INC.	0%	0	-	-10.7K	-100.00%
Sep 30, 2022	ROYAL BANK OF CANADA	0%	0	-	-137	-100.00%
Sep 30, 2022	GROUP ONE TRADING, L.P.	0%	0	-	-5.39K	-100.00%
Sep 30, 2022	WOLVERINE TRADING, LLC	0%	0	-	-10.1K	-100.00%
Sep 30, 2022	CITIGROUP INC	0%	0	-	-526	-100.00%
Sep 30, 2022	OPPENHEIMER & CO INC	0%	0	-	-98.05K	-100.00%
Sep 30, 2022	VANGUARD GROUP INC	0%	0	-	-2.04M	-100.00%
Sep 30, 2022	STATE STREET CORP	0%	0	-	-231.74K	-100.00%
Sep 30, 2022	NORTHERN TRUST CORP	0%	0	-	-105.48K	-100.00%
Sep 30, 2022	WELLS FARGO & COMPANY/MN	0%	0	-	-651	-100.00%
Sep 30, 2022	JPMORGAN CHASE & CO	0%	0	-	-94	-100.00%
Sep 30, 2022	BOLLARD GROUP LLC	0.03%	2.29K	4K	-32.03K	-93.33%
Sep 30, 2022	ABINGWORTH LLP	0%	0	-	-18.02M	-100.00%
Sep 30, 2022	BANK OF NEW YORK MELLON CORP	0%	0	-	-42.27K	-100.00%
Sep 30, 2022	BLACKROCK INC.	0%	0	-	-5.16K	-100.00%
Sep 30, 2022	MILLENNIUM MANAGEMENT LLC	0%	0	-	-46.32K	-100.00%
Sep 30, 2022	LEVY WEALTH MANAGEMENT GROUP, LLC	0%	0	-	-10K	-100.00%
Sep 30, 2022	BNP PARIBAS ARBITRAGE, SNC	0%	0	-	-140.02K	-100.00%
Sep 30, 2022	TWO SIGMA INVESTMENTS, LP	0%	0	-	-149.55K	-100.00%
Sep 30, 2022	GEODE CAPITAL MANAGEMENT, LLC	0%	0	-	-488.39K	-100.00%
Sep 30, 2022	RENAISSANCE TECHNOLOGIES LLC	0%	0	-	-550.13K	-100.00%
Sep 30, 2022	CLAYTON PARTNERS LLC	1.24%	100K	167K	100K	+100.00%
Sep 30, 2022	CUTLER GROUP LLC / CA	0%	0	-	-1.1K	-100.00%
Sep 30, 2022	ASPIRIANT, LLC	0%	0	-	-57.3K	-100.00%
Sep 30, 2022	CITADEL ADVISORS LLC	0%	0	-	-110.1K	-100.00%

Insiders

Among the SLNO insiders holding of 1.84% of the stake in company, VIVO OPPORTUNITY, LLC, 10 percent owner, holds the largest shares of 4.46M. CARLYLE GROUP INC., 10 percent owner, is the second largest SLNO insider with ownership of 1.78M shares. ANISH BHATNAGAR, CHIEF EXECUTIVE OFFICER, stands third with possession of 577.08K shares of that stake.

Insiders	Designation	Shares Held
VIVO OPPORTUNITY, LLC	10 percent owner	4.46M
CARLYLE GROUP INC.	10 percent owner	1.78M
ANISH BHATNAGAR	CHIEF EXECUTIVE OFFICER	577.08K
PERCEPTIVE ADVISORS LLC	10 percent owner	250K
MACKANESS JAMES H	CHIEF FINANCIAL OFFICER	105.18K
MANNING MEREDITH	Chief Commercial Officer	45.35K
HUANG MICHAEL F.	Sr. VP of Clinical Development	36.82K
SCHULER JACK W	10 percent owner	36.6K
YEN KRISTEN	SEE REMARKS	28.14K
HIRANO PATRICIA C	SEE REMARKS	13.21K
PAULS MATTHEW	director	6.5K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Jul 01, 2025	HIRANO PATRICIA C	SALE	82.76	3.83K	316.97K	13.21K
Jun 24, 2025	HIRANO PATRICIA C	SALE	84.25	266	22.41K	17.04K
Apr 01, 2025	HIRANO PATRICIA C	SALE	70.11	3.78K	265.16K	27.04K
Mar 28, 2025	PAULS MATTHEW	SALE	71.55	5.94K	424.8K	6.5K
Mar 28, 2025	HIRANO PATRICIA C	SALE	73.60	2.69K	198.06K	30.82K
Mar 28, 2025	VIVO OPPORTUNITY, LLC	SALE	70.60	333.56K	23.55M	4.46M
Mar 27, 2025	YEN KRISTEN	SALE	66.95	23.48K	1.57M	28.14K
Mar 27, 2025	HIRANO PATRICIA C	SALE	72.50	15.15K	1.1M	55.79K
Mar 27, 2025	VIVO OPPORTUNITY, LLC	SALE	67.80	1.1M	74.58M	4.79M
Mar 27, 2025	ANISH BHATNAGAR	SALE	69.30	199.23K	13.81M	577.08K
Mar 27, 2025	HUANG MICHAEL F.	SALE	70.03	10K	700.33K	36.82K
Mar 27, 2025	MACKANESS JAMES H	SALE	72.64	86	6.25K	105.18K
Mar 27, 2025	MANNING MEREDITH	SALE	67.04	37K	2.48M	45.35K
Mar 26, 2025	VIVO OPPORTUNITY, LLC	SALE	65.80	400K	26.32M	5.89M
Jan 03, 2025	MACKANESS JAMES H	SALE	46.18	3.79K	175.05K	111.3K
Jan 03, 2025	ANISH BHATNAGAR	SALE	46.18	10.15K	468.88K	698.46K
Jan 03, 2025	HIRANO PATRICIA C	SALE	46.18	1.46K	67.37K	105.9K
Jan 03, 2025	YEN KRISTEN	SALE	46.18	2.34K	108.05K	76.61K
Jan 02, 2025	ANISH BHATNAGAR	SALE	45.92	860	39.49K	708.62K
Jan 02, 2025	HIRANO PATRICIA C	SALE	45.92	124	5.69K	107.36K
Jan 02, 2025	MACKANESS JAMES H	SALE	45.92	321	14.74K	115.09K
Jan 02, 2025	YEN KRISTEN	SALE	45.92	198	9.09K	78.95K
Oct 01, 2024	ANISH BHATNAGAR	SALE	50.25	2.22K	111.55K	719.55K
Oct 01, 2024	HIRANO PATRICIA C	SALE	50.25	319	16.03K	108.93K
Oct 01, 2024	MACKANESS JAMES H	SALE	50.25	829	41.66K	119.17K
Oct 01, 2024	YEN KRISTEN	SALE	50.25	319	16.03K	81.47K
Aug 29, 2024	VIVO OPPORTUNITY, LLC	SALE	47.22	100K	4.72M	6.29M
Aug 29, 2024	MACKANESS JAMES H	SALE	47.83	1.28K	60.99K	127.25K
Aug 29, 2024	ANISH BHATNAGAR	SALE	47.83	10.84K	518.51K	741.19K
Aug 29, 2024	YEN KRISTEN	SALE	47.83	1.01K	48.26K	84.57K
Aug 29, 2024	HIRANO PATRICIA C	SALE	47.83	1.01K	48.26K	112.04K
Aug 28, 2024	VIVO OPPORTUNITY, LLC	SALE	47.35	425K	20.12M	6.39M
Aug 28, 2024	ANISH BHATNAGAR	SALE	48.03	26.35K	1.27M	799.58K
Aug 28, 2024	MACKANESS JAMES H	SALE	48.03	3.1K	148.88K	134.12K
Aug 28, 2024	YEN KRISTEN	SALE	48.03	2.45K	117.81K	90.01K
Aug 28, 2024	HIRANO PATRICIA C	SALE	48.03	2.45K	117.81K	117.48K
Aug 27, 2024	VIVO OPPORTUNITY, LLC	SALE	48.73	500K	24.37M	6.82M
Aug 06, 2024	ANISH BHATNAGAR	SALE	45.89	39.41K	1.81M	856.19K
Aug 06, 2024	YEN KRISTEN	SALE	45.89	3.4K	155.84K	95.28K
Aug 06, 2024	MACKANESS JAMES H	SALE	45.89	4.64K	212.75K	140.78K
Aug 06, 2024	HIRANO PATRICIA C	SALE	45.89	3.41K	156.35K	122.75K
Aug 05, 2024	MACKANESS JAMES H	SALE	46.14	2.99K	138.02K	148.91K
Aug 05, 2024	ANISH BHATNAGAR	SALE	46.14	25.42K	1.17M	925.32K
Aug 05, 2024	HIRANO PATRICIA C	SALE	46.14	2.2K	101.42K	128.72K
Aug 05, 2024	YEN KRISTEN	SALE	46.14	2.19K	101.1K	101.24K
Jul 01, 2024	MACKANESS JAMES H	SALE	41.63	5.62K	234.02K	55.76K
Jul 01, 2024	ANISH BHATNAGAR	SALE	41.63	15.06K	626.8K	133.53K
Jul 01, 2024	HIRANO PATRICIA C	SALE	41.63	1.7K	70.64K	48.75K
Jul 01, 2024	YEN KRISTEN	SALE	41.63	1.7K	70.64K	21.25K
Apr 30, 2024	VIVO OPPORTUNITY, LLC	SALE	45.13	351.24K	15.85M	7.32M
Apr 29, 2024	VIVO OPPORTUNITY, LLC	SALE	47.80	750K	35.85M	7.67M
Apr 01, 2024	MACKANESS JAMES H	SALE	41.67	2.07K	86.29K	62.95K
Apr 01, 2024	HIRANO PATRICIA C	SALE	41.12	1.33K	54.69K	41.81K
Apr 01, 2024	YEN KRISTEN	SALE	41.67	888	37K	23.42K
Apr 01, 2024	ANISH BHATNAGAR	SALE	41.67	7.6K	316.54K	152.79K
Jan 25, 2024	ANISH BHATNAGAR	SALE	48.30	2.53K	122.05K	171.77K
Jan 25, 2024	HIRANO PATRICIA C	SALE	48.30	832	40.19K	43.14K
Jan 25, 2024	YEN KRISTEN	SALE	48.30	397	19.18K	25.64K
Dec 14, 2023	HIRANO PATRICIA C	SALE	36.49	1.36K	49.58K	19.97K
Dec 13, 2023	YEN KRISTEN	SALE	37.76	17.92K	676.56K	2.04K
Dec 13, 2023	HIRANO PATRICIA C	SALE	38.79	4.89K	189.51K	21.33K
Dec 12, 2023	YEN KRISTEN	SALE	37.02	16.28K	602.91K	2.04K
Dec 11, 2023	ANISH BHATNAGAR	SALE	37.01	6.93K	256.49K	24.3K
Dec 11, 2023	MACKANESS JAMES H	SALE	37.06	13.85K	513.31K	12.13K
Nov 30, 2023	MACKANESS JAMES H	SALE	28.65	4.19K	119.94K	21.3K
Nov 30, 2023	YEN KRISTEN	SALE	28.65	3.96K	113.55K	21.95K
Nov 30, 2023	ANISH BHATNAGAR	SALE	28.65	27.72K	794.12K	108.06K
Nov 30, 2023	HIRANO PATRICIA C	SALE	28.65	3.82K	109.54K	26.22K
Nov 29, 2023	MACKANESS JAMES H	SALE	28.26	2.04K	57.69K	25.49K
Nov 29, 2023	HIRANO PATRICIA C	SALE	28.26	1.86K	52.69K	30.04K
Nov 29, 2023	ANISH BHATNAGAR	SALE	28.26	13.51K	381.86K	135.78K
Nov 29, 2023	YEN KRISTEN	SALE	28.26	1.93K	54.61K	25.91K
Nov 28, 2023	MACKANESS JAMES H	SALE	27.59	673	18.57K	29.69K
Nov 28, 2023	YEN KRISTEN	SALE	27.59	637	17.58K	29.89K
Nov 28, 2023	ANISH BHATNAGAR	SALE	27.59	4.46K	123.02K	163.61K
Nov 28, 2023	HIRANO PATRICIA C	SALE	27.59	615	16.97K	33.88K
Sep 28, 2023	PERCEPTIVE ADVISORS LLC	PURCHASE	0.01	250K	2.5K	250K
Sep 26, 2023	PERCEPTIVE ADVISORS LLC	PURCHASE	7.65	5.7K	43.63K	2.21M
Jun 06, 2023	PERCEPTIVE ADVISORS LLC	PURCHASE	5.93	200	1.19K	2.21M
Jun 05, 2023	PERCEPTIVE ADVISORS LLC	PURCHASE	5.98	78.47K	469.24K	2.21M
Jun 02, 2023	PERCEPTIVE ADVISORS LLC	PURCHASE	5.93	64.63K	383.26K	2.13M
Jun 01, 2023	PERCEPTIVE ADVISORS LLC	PURCHASE	5.59	7.5K	41.93K	2.06M
May 31, 2023	PERCEPTIVE ADVISORS LLC	PURCHASE	5.28	10K	52.8K	2.06M
May 30, 2023	PERCEPTIVE ADVISORS LLC	PURCHASE	5.34	17.5K	93.45K	2.05M
May 26, 2023	PERCEPTIVE ADVISORS LLC	PURCHASE	5.27	22.5K	118.58K	2.03M
May 25, 2023	PERCEPTIVE ADVISORS LLC	PURCHASE	5.18	37.5K	194.25K	2.01M
May 24, 2023	PERCEPTIVE ADVISORS LLC	PURCHASE	5.48	25K	137K	1.97M
May 23, 2023	PERCEPTIVE ADVISORS LLC	PURCHASE	5.45	27.5K	149.88K	1.94M
May 22, 2023	PERCEPTIVE ADVISORS LLC	PURCHASE	5.12	27.3K	139.78K	1.92M
May 19, 2023	PERCEPTIVE ADVISORS LLC	PURCHASE	4.62	25.2K	116.42K	1.89M
May 08, 2023	CARLYLE GROUP INC.	PURCHASE	2.50	1.78M	4.45M	1.78M
Dec 09, 2022	SCHULER JACK W	SALE	0.91	10K	9.1K	36.6K
Dec 08, 2022	SCHULER JACK W	SALE	0.93	10K	9.3K	46.6K
Dec 07, 2022	SCHULER JACK W	SALE	0.96	10K	9.6K	56.6K
Dec 06, 2022	SCHULER JACK W	SALE	0.99	10K	9.9K	66.6K
Dec 05, 2022	SCHULER JACK W	SALE	0.97	10K	9.7K	76.6K
Dec 02, 2022	SCHULER JACK W	SALE	1.00	10K	10K	86.6K
Dec 01, 2022	SCHULER JACK W	SALE	1.03	10K	10.3K	96.6K
Nov 30, 2022	SCHULER JACK W	SALE	0.99	10K	9.9K	106.6K
Nov 29, 2022	SCHULER JACK W	SALE	1.01	10K	10.1K	116.6K
Nov 28, 2022	SCHULER JACK W	SALE	1.05	10K	10.5K	126.6K
Nov 25, 2022	SCHULER JACK W	SALE	1.07	10K	10.7K	136.6K
Nov 23, 2022	SCHULER JACK W	SALE	1.11	10.4K	11.54K	146.6K
Nov 22, 2022	SCHULER JACK W	SALE	1.07	10K	10.7K	157K
Nov 21, 2022	SCHULER JACK W	SALE	1.13	14.53K	16.42K	167K
Nov 18, 2022	SCHULER JACK W	SALE	1.15	28.47K	32.75K	181.53K
Nov 17, 2022	SCHULER JACK W	SALE	1.15	11.44K	13.16K	210K
Nov 16, 2022	SCHULER JACK W	SALE	1.26	116.88K	147.27K	221.44K
Nov 15, 2022	SCHULER JACK W	SALE	1.09	10K	10.9K	338.32K
Nov 14, 2022	SCHULER JACK W	SALE	1.07	10K	10.7K	348.32K
Nov 09, 2022	SCHULER JACK W	SALE	0.94	10K	9.4K	358.32K
Nov 08, 2022	SCHULER JACK W	SALE	0.99	10K	9.9K	368.32K
Nov 07, 2022	SCHULER JACK W	SALE	0.99	10K	9.9K	378.32K
Nov 04, 2022	SCHULER JACK W	SALE	0.99	10K	9.9K	388.32K
Nov 03, 2022	SCHULER JACK W	SALE	1.01	10K	10.1K	398.32K
Nov 02, 2022	SCHULER JACK W	SALE	0.97	10K	9.7K	408.32K
Nov 01, 2022	SCHULER JACK W	SALE	0.99	10K	9.9K	418.32K
Oct 31, 2022	SCHULER JACK W	SALE	1.00	10K	10K	428.32K
Oct 28, 2022	SCHULER JACK W	SALE	1.08	10K	10.8K	438.32K
Oct 27, 2022	SCHULER JACK W	SALE	1.16	9.1K	10.56K	448.32K
Oct 26, 2022	SCHULER JACK W	SALE	1.26	8.84K	11.14K	457.42K
Oct 13, 2022	SCHULER JACK W	SALE	1.52	400	608	466.27K
Aug 08, 2022	SCHULER JACK W	SALE	2.64	6.82K	18.01K	625.69K
Aug 05, 2022	SCHULER JACK W	SALE	2.52	6.7K	16.89K	632.52K
Aug 04, 2022	SCHULER JACK W	SALE	2.46	5.1K	12.55K	639.21K
Aug 03, 2022	SCHULER JACK W	SALE	2.54	2.52K	6.39K	644.32K
Aug 02, 2022	SCHULER JACK W	SALE	2.55	353	901	646.84K

Frequently Asked Questions