How many institutions own ORKA stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own ORKA shares is 115, representing 93.2% of the company's common stock.

Who are the major shareholders selling Oruka Therapeutics, Inc. stock?

KENNEDY CAPITAL MANAGEMENT LLC, in the last quarter, reduced its stake in ORKA by -25.66% restricting it's holding to 48.27 thousand shares of worth nearly $928.16K. ABRDN PLC also lessened -3.44% of the ORKA shares from its portfolio, reducing its holding to 75.68 thousand shares of worth $1.46M. MORGAN STANLEY also shunned ORKA shares holding by -35.28% last quarter which brought its holding to 134.83 thousand shares worth $2.59M.

Investors who are buying ORKA stock?

As per its latest 13F filing, BLACKSTONE INC. increased its stake in ORKA by 2.86% in the last quarter. The institutional holder raised its holding to 850.4 thousand shares having worth more than $16.35M. MERCER GLOBAL ADVISORS INC /ADV also added 0.01% more shares of ORKA to its portfolio, raising its holding to 852.41 thousand shares of worth $16.39M. RESOLUTE CAPITAL ASSET PARTNERS LLC also increased its ORKA shares holding by 100% which brought its holding to 75 thousand shares worth $1.44M.

ORKA's major insiders: who are they?

The insider with the most stakes in ORKA is Venrock Healthcare Capital Partners III, L.P. , 10 percent owner at the company. Additionally, ORKA stock is highly held by Chief Operating Officer Sandler Laura Lee and Chief Medical Officer Goncalves Joana among others.

Did an insider recently sell ORKA stock?

Company executives, directors, and other insiders own 3.82% percent of Oruka Therapeutics, Inc.'s stock. Within the last six months, there have been 2 transaction(s) in which ORKA insiders have sold stock, totaling 4.19K shares. Insiders that have sold shares include SANDLER LAURA LEE and GONCALVES JOANA.

Which insider recently purchased ORKA stock?

There have been 0 transaction(s) during the past 6-months in which Oruka Therapeutics, Inc. insiders have bought stock, totalling 0 shares

How much of ORKA does insiders own?

Around 206.6K Oruka Therapeutics, Inc. shares are held by insiders, which represents about 3.82% of ORKA stock.

Who is the insider with the largest stake?

ORKA 10 percent owner, Venrock Healthcare Capital Partners III, L.P. holds the largest portfolio of the company's shares. ORKA shares owned by Venrock total nearly 4.15 million.

Which institution holds the most shares in ORKA?

BLACKSTONE INC. is the largest institutional owner in ORKA which holds 850.4 thousand shares worth $16.35M or 2.01% of the total ORKA shares outstanding followed by MERCER GLOBAL ADVISORS INC /ADV with ownership of 852.41 thousand shares representing 2.02% of the ORKA ownership. NUVEEN, LLC is the third largest stakeholder with 35.31 thousand shares or 0.08% of the ownership worth more than $679.07K.

Is Oruka Therapeutics, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the ORKA is concerned, it is a stock which is optionable.

Is there a short position on ORKA's shares?

Number of ORKA shares short is 3.36M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding ORKA shares are there?

As of today, 37.45M shares of ORKA are outstanding.

Is there many float in ORKA stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, ORKA has 22.41M shares in float.

ORKA short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for ORKA is 19.35.

Oruka Therapeutics (ORKA) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares8.97

Short Percent Of Float14.37

Shares Outstanding37.45M

Shares Float22.41M

Shares Short3.36M

Short Ratio19.35

14.37%

Short % of Float

8.97%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

3.82% Percentage of Shares held by All Insiders

93.2% Percentage of Shares held by All Institutions

96.9% Percentage of Float held by Institutions

115

Number of Institutions Holding Shares

Institutional Ownership

About 93.2% of ORKA shares are held by financial institutions. BLACKSTONE INC. is the top corporate investor, holding 850.4K shares valued at $16.35M. A 2.01% stake in Oruka Therapeutics, Inc. is owned by the company. MERCER GLOBAL ADVISORS INC /ADV owns 852.41K shares valued at $16.39M, which translates its holding of 2.02% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	BLACKSTONE INC.	2.01%	850.4K	16.35M	23.68K	+2.86%
Sep 30, 2025	MERCER GLOBAL ADVISORS INC /ADV	2.02%	852.41K	16.39M	73	+0.01%
Sep 30, 2025	NUVEEN, LLC	0.08%	35.31K	679.07K	0	0
Sep 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.11%	48.27K	928.16K	-16.66K	-25.66%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.11%	45.88K	882.2K	0	0
Sep 30, 2025	JEFFERIES FINANCIAL GROUP INC.	0.15%	64.99K	1.25M	0	0
Sep 30, 2025	B GROUP, INC.	0.18%	75K	1.44M	0	0
Sep 30, 2025	RESOLUTE CAPITAL ASSET PARTNERS LLC	0.18%	75K	1.44M	75K	+100.00%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.08%	34.11K	655.96K	34.11K	+100.00%
Sep 30, 2025	FINANCIAL ENHANCEMENT GROUP LLC	0.08%	32.82K	742.2K	32.82K	+100.00%
Sep 30, 2025	RHUMBLINE ADVISERS	0.07%	30.33K	583.18K	1.76K	+6.15%
Sep 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.07%	29.18K	562.96K	29.18K	+100.00%
Sep 30, 2025	ABRDN PLC	0.18%	75.68K	1.46M	-2.7K	-3.44%
Sep 30, 2025	MORGAN STANLEY	0.32%	134.83K	2.59M	-73.5K	-35.28%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	1.48%	626.81K	12.05M	215.93K	+52.55%
Sep 30, 2025	AFFINITY ASSET ADVISORS, LLC	2.27%	959.18K	18.45M	355.7K	+58.94%
Sep 30, 2025	POLAR CAPITAL HOLDINGS PLC	2.44%	1.03M	19.85M	57.31K	+5.88%
Sep 30, 2025	BRAIDWELL LP	3.27%	1.38M	26.58M	-142.49K	-9.34%
Sep 30, 2025	VANGUARD GROUP INC	4.21%	1.78M	34.17M	-40.64K	-2.24%
Sep 30, 2025	RTW INVESTMENTS, LP	4.61%	1.95M	37.41M	0	0
Sep 30, 2025	BLACKROCK, INC.	5.22%	2.2M	42.39M	215.67K	+10.84%
Sep 30, 2025	DEEP TRACK CAPITAL, LP	6.29%	2.65M	51.05M	735.98K	+38.36%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.19%	79K	1.52M	60.15K	+319.09%
Sep 30, 2025	CITADEL ADVISORS LLC	0.75%	316.89K	6.09M	316.89K	+100.00%
Sep 30, 2025	CANDRIAM S.C.A.	0.87%	366.99K	7.06M	250.3K	+214.48%
Sep 30, 2025	TORONTO DOMINION BANK	0.14%	58.33K	1.12M	0	0
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.17%	70.63K	1.36M	7.12K	+11.22%
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.17%	72.6K	1.4M	72.6K	+100.00%
Sep 30, 2025	VIKING GLOBAL INVESTORS LP	6.31%	2.67M	51.28M	2.67M	+100.00%
Sep 30, 2025	FMR LLC	17.18%	7.26M	139.56M	1.64M	+29.22%
Sep 30, 2025	GROUP ONE TRADING, L.P.	0%	100	1.92M	100	+100.00%
Sep 30, 2025	ACTIVEST WEALTH MANAGEMENT	0%	166	3.19K	0	0
Sep 30, 2025	US BANCORP \DE\	0%	178	3.42K	178	+100.00%
Sep 30, 2025	CWM, LLC	0%	394	8K	394	+100.00%
Sep 30, 2025	CORMORANT ASSET MANAGEMENT, LP	1.26%	533.34K	10.26M	533.34K	+100.00%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.58%	246.93K	4.75M	162.92K	+193.95%
Sep 30, 2025	D. E. SHAW & CO., INC.	0.23%	95.42K	1.83M	27.77K	+41.06%
Sep 30, 2025	CABLE CAR CAPITAL LLC	1.18%	500K	9.62M	-100K	-16.67%
Sep 30, 2025	SR ONE CAPITAL MANAGEMENT, LP	1.02%	430.33K	8.28M	0	0
Sep 30, 2025	SIMPLEX TRADING, LLC	0%	729	14K	729	+100.00%
Sep 30, 2025	GF FUND MANAGEMENT CO. LTD.	0%	806	15.5K	-90	-10.04%
Sep 30, 2025	AMALGAMATED BANK	0%	929	18K	0	0
Sep 30, 2025	STONE HOUSE INVESTMENT MANAGEMENT, LLC	0%	1K	19.23K	1K	+100.00%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	12.51K	240.49K	-2.52K	-16.77%
Sep 30, 2025	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0%	1.45K	27.85K	2	+0.14%
Sep 30, 2025	STERLING CAPITAL MANAGEMENT LLC	0%	1.88K	36.1K	1.14K	+155.72%
Sep 30, 2025	PNC FINANCIAL SERVICES GROUP, INC.	0%	2.01K	38.73K	2.01K	+100.00%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.01%	2.25K	43.33K	2.25K	+100.00%
Sep 30, 2025	VR ADVISER, LLC	9.82%	4.15M	79.77M	0	0
Sep 30, 2025	FAIRMOUNT FUNDS MANAGEMENT LLC	8.77%	3.71M	71.25M	333.34K	+9.89%
Sep 30, 2025	COMMODORE CAPITAL LP	4.15%	1.75M	33.71M	333.34K	+23.48%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.63%	689.97K	13.27M	-17.43K	-2.46%
Sep 30, 2025	AVIDITY PARTNERS MANAGEMENT LP	1.56%	660.42K	12.7M	308.3K	+87.55%
Sep 30, 2025	STATE STREET CORP	1.54%	652.03K	12.54M	279.22K	+74.90%
Sep 30, 2025	NORTHERN TRUST CORP	0.52%	219.71K	4.23M	-2.47K	-1.11%
Sep 30, 2025	GREAT POINT PARTNERS LLC	0.43%	183.33K	3.53M	183.33K	+100.00%
Sep 30, 2025	BARCLAYS PLC	0.23%	95.33K	1.83M	4.17K	+4.57%
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.22%	91.09K	1.75M	91.09K	+100.00%
Sep 30, 2025	UBS GROUP AG	0.2%	86.56K	1.66M	-24.09K	-21.77%
Sep 30, 2025	PALO ALTO INVESTORS LP	0.14%	59.99K	791.31K	59.99K	+100.00%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.01%	2.48K	47.63K	0	0
Sep 30, 2025	AMERITAS INVESTMENT PARTNERS, INC.	0.01%	2.78K	53.4K	0	0
Sep 30, 2025	DEUTSCHE BANK AG\	0.05%	22.12K	425.35K	2.76K	+14.25%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.05%	20.86K	401.06K	3.4K	+19.48%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	16.51K	317.55K	0	0
Sep 30, 2025	INVESCO LTD.	0.04%	16.32K	313.8K	1.01K	+6.58%
Sep 30, 2025	EMPIRICAL FINANCIAL SERVICES, LLC D.B.A. EMPIRICAL WEALTH MANAGEMENT	0.04%	15.41K	296.26K	15.41K	+100.00%
Sep 30, 2025	JPMORGAN CHASE & CO	0.03%	14.48K	278.43K	-946	-6.13%
Sep 30, 2025	ALTFEST L J & CO INC	0.03%	13.3K	255.7K	13.3K	+100.00%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.03%	12.79K	245.89K	12.79K	+100.00%
Sep 30, 2025	CITIGROUP INC	0.01%	3.37K	64.83K	-6.47K	-65.74%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.01%	5.75K	110.52K	2.94K	+105.03%
Sep 30, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	6.57K	126.25K	-955	-12.70%
Sep 30, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.02%	7.36K	141.49K	1.25K	+20.47%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.02%	8.6K	165.38K	0	0
Sep 30, 2025	QUEST PARTNERS LLC	0.03%	10.76K	206.93K	-5.3K	-33.01%
Sep 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	2.46%	1.04M	19.94M	707K	+214.24%
Sep 30, 2025	FRANKLIN RESOURCES INC	2.52%	1.07M	20.49M	52.81K	+5.21%
Sep 30, 2025	PERCEPTIVE ADVISORS LLC	3%	1.27M	24.38M	1.27M	+100.00%
Sep 30, 2025	AVORO CAPITAL ADVISORS LLC	3.16%	1.33M	25.64M	1.33M	+100.00%
Sep 30, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.12%	51.91K	998.19K	-839	-1.59%
Sep 30, 2025	JANE STREET GROUP, LLC	0.13%	56.2K	1.08M	56.2K	+100.00%
Sep 30, 2025	WOODLINE PARTNERS LP	1.36%	574.33K	11.04M	183.43K	+46.92%
Jun 30, 2025	FRANKLIN RESOURCES INC	2.4%	1.01M	11.36M	292.42K	+40.58%
Jun 30, 2025	POLAR CAPITAL HOLDINGS PLC	2.31%	975K	10.93M	-75K	-7.14%
Jun 30, 2025	SR ONE CAPITAL MANAGEMENT, LP	1.02%	430.33K	4.82M	0	0
Jun 30, 2025	MORGAN STANLEY	0.49%	208.33K	2.34M	-319.46K	-60.53%
Jun 30, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.39%	165.39K	1.85M	165.39K	+100.00%
Jun 30, 2025	IKARIAN CAPITAL, LLC	0.16%	68.57K	768.72K	-106.43K	-60.81%
Jun 30, 2025	QUEST PARTNERS LLC	0.04%	16.06K	180.08K	-271	-1.66%
Jun 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.04%	15.03K	168.43K	15.03K	+100.00%
Jun 30, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0.04%	14.89K	166.94K	14.89K	+100.00%
Jun 30, 2025	ROYAL BANK OF CANADA	0.01%	2.5K	27K	2.5K	+100.00%
Jun 30, 2025	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0%	1.45K	16.21K	193	+15.40%
Jun 30, 2025	STERLING CAPITAL MANAGEMENT LLC	0%	734	8.23K	734	+100.00%
Jun 30, 2025	ACTIVEST WEALTH MANAGEMENT	0%	166	1.86K	0	0
Jun 30, 2025	DAIWA SECURITIES GROUP INC.	0%	116	1K	0	0
Jun 30, 2025	J.SAFRA ASSET MANAGEMENT CORP	0%	24	266	24	+100.00%
Jun 30, 2025	NATIONAL BANK OF CANADA /FI/	0%	8	89	0	0
Jun 30, 2025	ALLWORTH FINANCIAL LP	0%	5	57	5	+100.00%
Jun 30, 2025	OMERS ADMINISTRATION CORP	0%	0	-	-44.9K	-100.00%
Jun 30, 2025	COLDSTREAM CAPITAL MANAGEMENT INC	0%	0	-	-180	-100.00%
Jun 30, 2025	BRAIDWELL LP	3.61%	1.52M	17.09M	-47.58K	-3.03%
Jun 30, 2025	COMMODORE CAPITAL LP	3.36%	1.42M	15.91M	0	0
Jun 30, 2025	AFFINITY ASSET ADVISORS, LLC	1.43%	603.48K	6.77M	58.12K	+10.66%
Jun 30, 2025	GROUP ONE TRADING, L.P.	0%	0	-	-2.11K	-100.00%
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.78%	330K	3.7M	-12.4K	-3.62%
Jun 30, 2025	NORTHERN TRUST CORP	0.53%	222.18K	2.49M	162.59K	+272.88%
Jun 30, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.34%	142.78K	1.6M	10K	+7.53%
Jun 30, 2025	CANDRIAM S.C.A.	0.28%	116.7K	1.31M	0	0
Jun 30, 2025	UBS GROUP AG	0.26%	110.65K	1.24M	76.76K	+226.55%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.2%	84K	941.66K	68.39K	+438.20%
Jun 30, 2025	ABRDN PLC	0.19%	78.38K	878.64K	78.38K	+100.00%
Jun 30, 2025		0.08%	35.31K	395.86K	35.31K	+100.00%
Jun 30, 2025	JEFFERIES FINANCIAL GROUP INC.	0.15%	64.99K	728.55K	-340.04K	-83.95%
Jun 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.15%	64.93K	727.82K	-823	-1.25%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.15%	63.51K	711.94K	63.51K	+100.00%
Jun 30, 2025	TORONTO DOMINION BANK	0.14%	58.33K	653.9K	0	0
Jun 30, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.12%	52.75K	591.29K	9.83K	+22.90%
Jun 30, 2025	D. E. SHAW & CO., INC.	0.16%	67.65K	758.3K	67.65K	+100.00%
Jun 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.01%	2.8K	31.42M	2.31K	+463.98%
Jun 30, 2025	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0%	1.7K	19.02M	1.7K	+100.00%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	0%	0	-	-87.5K	-100.00%
Jun 30, 2025	FMR LLC	13.3%	5.62M	62.96M	54.66K	+0.98%
Jun 30, 2025	VR ADVISER, LLC	9.82%	4.15M	46.5M	0	0
Jun 30, 2025	FAIRMOUNT FUNDS MANAGEMENT LLC	7.98%	3.37M	37.8M	0	0
Jun 30, 2025	TWO SIGMA INVESTMENTS, LP	0.08%	32.34K	362.55K	10.51K	+48.15%
Jun 30, 2025	RHUMBLINE ADVISERS	0.07%	28.57K	320.26K	28.57K	+100.00%
Jun 30, 2025	MERCER GLOBAL ADVISORS INC /ADV	2.02%	852.34K	9.55M	852.34K	+100.00%
Jun 30, 2025	BLACKSTONE INC.	1.96%	826.72K	9.27M	43.07K	+5.50%
Jun 30, 2025	CABLE CAR CAPITAL LLC	1.42%	600K	6.73M	150K	+33.33%
Jun 30, 2025	BARCLAYS PLC	0.22%	91.16K	1.02M	15.83K	+21.01%
Jun 30, 2025	TD ASSET MANAGEMENT INC	0.11%	45.88K	514.27K	0	0
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.08%	33.96K	380.71K	-316.07K	-90.30%
Jun 30, 2025	WOODLINE PARTNERS LP	0.93%	390.9K	4.38M	100	+0.03%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.04%	18.85K	211.3K	13.99K	+287.60%
Jun 30, 2025	WELLS FARGO & COMPANY/MN	0.04%	17.46K	195.67K	17.46K	+100.00%
Jun 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	16.51K	185.11K	16.51K	+100.00%
Jun 30, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	1.38%	583.33K	6.54M	0	0
Jun 30, 2025	AVIDITY PARTNERS MANAGEMENT LP	0.83%	352.12K	3.95M	0	0
Jun 30, 2025	DEUTSCHE BANK AG\	0.05%	19.36K	217.04K	19.36K	+100.00%
Jun 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.05%	19K	213.02K	-34.61K	-64.56%
Jun 30, 2025	JPMORGAN CHASE & CO	0.04%	15.43K	172.91K	13.12K	+567.75%
Jun 30, 2025	BLACKROCK, INC.	4.71%	1.99M	22.3M	1.24M	+166.01%
Jun 30, 2025	RTW INVESTMENTS, LP	4.61%	1.95M	21.81M	0	0
Jun 30, 2025	DEEP TRACK CAPITAL, LP	4.54%	1.92M	21.51M	474.09K	+32.82%
Jun 30, 2025	VANGUARD GROUP INC	4.3%	1.82M	20.37M	179.87K	+10.99%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.68%	707.41K	7.93M	354.82K	+100.63%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.97%	410.88K	4.61M	-721	-0.18%
Jun 30, 2025	STATE STREET CORP	0.88%	372.81K	4.18M	286.13K	+330.09%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.17%	72.25K	809.91K	-171.95K	-70.41%
Jun 30, 2025	B GROUP, INC.	0.18%	75K	840.75K	16.79K	+28.83%
Jun 30, 2025	NUVEEN, LLC	0.08%	35.31K	395.86K	35.31K	+100.00%
Mar 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.12%	52.03K	533.79K	-100.06K	-65.79%
Mar 31, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.13%	53.62K	550.09K	53.62K	+100.00%
Mar 31, 2025	FMR LLC	13.34%	5.56M	57.06M	49.51K	+0.90%
Mar 31, 2025	JEFFERIES FINANCIAL GROUP INC.	0.97%	405.03K	4.16M	55K	+15.71%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.99%	411.6K	4.22M	-915.29K	-68.98%
Mar 31, 2025		0.14%	58.22K	597.29K	38.22K	+191.08%
Mar 31, 2025	TORONTO DOMINION BANK	0.14%	58.33K	598.49K	0	0
Mar 31, 2025	NORTHERN TRUST CORP	0.14%	59.59K	611.34K	-4.46K	-6.96%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.85%	352.59K	3.62M	10.17K	+2.97%
Mar 31, 2025	SR ONE CAPITAL MANAGEMENT, LP	1.03%	430.33K	4.42M	0	0
Mar 31, 2025	CABLE CAR CAPITAL LLC	1.08%	450K	4.62M	116.63K	+34.98%
Mar 31, 2025	MORGAN STANLEY	1.27%	527.79K	5.42M	121.79K	+30.00%
Mar 31, 2025	UBS GROUP AG	0.08%	33.88K	347.64K	8.72K	+34.66%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.09%	35.8K	367.31K	35.8K	+100.00%
Mar 31, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.1%	42.92K	440.35K	621	+1.47%
Mar 31, 2025	COMMODORE CAPITAL LP	3.41%	1.42M	14.57M	0	0
Mar 31, 2025	DEEP TRACK CAPITAL, LP	3.47%	1.44M	14.82M	694.71K	+92.63%
Mar 31, 2025	ALLOSTERY INVESTMENTS LP	0.05%	20K	205.2K	0	0
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.05%	21.83K	223.99K	21.83K	+100.00%
Mar 31, 2025	SQUAREPOINT OPS LLC	0.05%	22.02K	225.95K	9.85K	+80.88%
Mar 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.82%	342.4K	3.51M	-18.33K	-5.08%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.84%	350.04K	3.59M	350.04K	+100.00%
Mar 31, 2025	OCCUDO QUANTITATIVE STRATEGIES LP	0.06%	24.8K	310.05K	24.8K	+100.00%
Mar 31, 2025	MAN GROUP PLC	0.07%	29.37K	301.29K	29.37K	+100.00%
Mar 31, 2025	OMERS ADMINISTRATION CORP	0.11%	44.9K	460.67K	25.1K	+126.77%
Mar 31, 2025	TD ASSET MANAGEMENT INC	0.11%	45.88K	470.69K	-49.2K	-51.75%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.13%	54.13K	555.33K	23.82K	+78.60%
Mar 31, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.16%	65.75K	674.59K	5.26K	+8.69%
Mar 31, 2025	BARCLAYS PLC	0.18%	75.33K	773K	750	+1.01%
Mar 31, 2025	STATE STREET CORP	0.21%	86.68K	889.35K	61.66K	+246.41%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.21%	87.5K	897.76K	-7.59K	-7.98%
Mar 31, 2025	CANDRIAM S.C.A.	0.28%	116.7K	1.2M	116.7K	+100.00%
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.32%	132.78K	1.36M	132.78K	+100.00%
Mar 31, 2025	IKARIAN CAPITAL, LLC	0.42%	175K	1.8M	175K	+100.00%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.59%	244.2K	2.51M	244.2K	+100.00%
Mar 31, 2025	REDMILE GROUP, LLC	0.93%	386.96K	3.97M	-24.77K	-6.01%
Mar 31, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	1.4%	583.33K	5.98M	0	0
Mar 31, 2025	FRANKLIN RESOURCES INC	1.73%	720.55K	7.39M	0	0
Mar 31, 2025	BLACKROCK, INC.	1.79%	747.67K	7.67M	-3.76K	-0.50%
Mar 31, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.09%	35.91K	368K	35.91K	+100.00%
Mar 31, 2025	WEISS ASSET MANAGEMENT LP	0.1%	40K	410.4K	0	0
Mar 31, 2025	AFFINITY ASSET ADVISORS, LLC	1.31%	545.36K	5.6M	176.66K	+47.92%
Mar 31, 2025	HRT FINANCIAL LP	0.11%	46.51K	477K	46.51K	+100.00%
Mar 31, 2025	BLACKSTONE INC.	1.88%	783.65K	8.04M	543.48K	+226.29%
Mar 31, 2025	POLAR CAPITAL HOLDINGS PLC	2.52%	1.05M	10.77M	500K	+90.91%
Mar 31, 2025	RTW INVESTMENTS, LP	4.67%	1.95M	19.96M	0	0
Mar 31, 2025	VR ADVISER, LLC	9.95%	4.15M	42.56M	862.81K	+26.26%
Mar 31, 2025	BRAIDWELL LP	3.77%	1.57M	16.13M	424.75K	+37.01%
Mar 31, 2025	WOODLINE PARTNERS LP	0.94%	390.8K	4.01M	-165	-0.04%
Mar 31, 2025	VANGUARD GROUP INC	3.93%	1.64M	16.8M	26.78K	+1.66%

Insiders

Among the ORKA insiders holding of 3.82% of the stake in company, VENROCK HEALTHCARE CAPITAL PARTNERS III, L.P., 10 percent owner, holds the largest shares of 4.15M. SANDLER LAURA LEE, Chief Operating Officer, is the second largest ORKA insider with ownership of 205.08K shares. GONCALVES JOANA, Chief Medical Officer, stands third with possession of 1.52K shares of that stake.

Insiders	Designation	Shares Held
VENROCK HEALTHCARE CAPITAL PARTNERS III, L.P.	10 percent owner	4.15M
SANDLER LAURA LEE	Chief Operating Officer	205.08K
GONCALVES JOANA	Chief Medical Officer	1.52K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Jan 02, 2026	SANDLER LAURA LEE	SALE	29.75	1.11K	32.97K	205.08K
Dec 19, 2025	GONCALVES JOANA	SALE	31.58	3.08K	97.26K	1.52K
Feb 14, 2025	VENROCK HEALTHCARE CAPITAL PARTNERS III, L.P.	PURCHASE	11.44	88.79K	1.02M	4.15M
Feb 13, 2025	VENROCK HEALTHCARE CAPITAL PARTNERS III, L.P.	PURCHASE	11.63	14.95K	173.87K	4.06M
Feb 12, 2025	VENROCK HEALTHCARE CAPITAL PARTNERS III, L.P.	PURCHASE	11.86	8.97K	106.4K	4.04M
Feb 11, 2025	VENROCK HEALTHCARE CAPITAL PARTNERS III, L.P.	PURCHASE	10.95	9.59K	105.04K	4.04M
Feb 10, 2025	VENROCK HEALTHCARE CAPITAL PARTNERS III, L.P.	PURCHASE	10.90	574	6.26K	4.03M

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES4.19K2

NET SHARES-4.19K2

SHARES HELD206.6K2

% NET SHARES-102.03%0%

Frequently Asked Questions