How many institutions own LYRA stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own LYRA shares is 44, representing 38.13% of the company's common stock.

Who are the major shareholders selling Lyra Therapeutics, Inc. stock?

VANGUARD GROUP INC, in the last quarter, reduced its stake in LYRA by -100% restricting it's holding to 0 shares of worth nearly -. IFP ADVISORS, INC also lessened -50% of the LYRA shares from its portfolio, reducing its holding to 1 shares of worth $3.00. FORTITUDE FAMILY OFFICE, LLC also shunned LYRA shares holding by -100% last quarter which brought its holding to 0 shares worth -.

Investors who are buying LYRA stock?

As per its latest 13F filing, BANK OF AMERICA CORP /DE/ increased its stake in LYRA by 1,016.67% in the last quarter. The institutional holder raised its holding to 201 shares having worth more than $619.00. TOWER RESEARCH CAPITAL LLC (TRC) also added 310.3% more shares of LYRA to its portfolio, raising its holding to 2.19 thousand shares of worth $6.75K. ARTIA GLOBAL PARTNERS LP also increased its LYRA shares holding by 100% which brought its holding to 8.76 thousand shares worth $26.97K.

LYRA's major insiders: who are they?

The insider with the most stakes in LYRA is EDELMAN JOSEPH , at the company. Additionally, LYRA stock is highly held by North Bridge Venture Management VI, L.P. and President & CEO Palasis Maria among others.

Did an insider recently sell LYRA stock?

Company executives, directors, and other insiders own 0.67% percent of Lyra Therapeutics, Inc.'s stock. Within the last six months, there have been 8 transaction(s) in which LYRA insiders have sold stock, totaling 14.21K shares. Insiders that have sold shares include PALASIS MARIA, CAVALIER JASON, and PERCEPTIVE ADVISORS LLC.

Which insider recently purchased LYRA stock?

There have been 0 transaction(s) during the past 6-months in which Lyra Therapeutics, Inc. insiders have bought stock, totalling 0 shares

How much of LYRA does insiders own?

Around 1.73M Lyra Therapeutics, Inc. shares are held by insiders, which represents about 0.67% of LYRA stock.

Who is the insider with the largest stake?

LYRA , EDELMAN JOSEPH holds the largest portfolio of the company's shares. LYRA shares owned by EDELMAN total nearly 7.86 million.

Which institution holds the most shares in LYRA?

COMERICA BANK is the largest institutional owner in LYRA which holds 23 shares worth $71.00 or 0% of the total LYRA shares outstanding followed by BRYN MAWR TRUST CO with ownership of 20 shares representing 0% of the LYRA ownership. VANGUARD GROUP INC is the third largest stakeholder with 0 shares or 0% of the ownership worth more than -.

Is Lyra Therapeutics, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the LYRA is concerned, it is a stock which is not optionable.

Is there a short position on LYRA's shares?

Number of LYRA shares short is 50.50K. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding LYRA shares are there?

As of today, 1.64M shares of LYRA are outstanding.

Is there many float in LYRA stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, LYRA has 1.12M shares in float.

LYRA short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for LYRA is 1.68.

Lyra Therapeutics (LYRA) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableNo

Short Percent Of Outstanding Shares3.07

Short Percent Of Float3.66

Shares Outstanding1.64M

Shares Float1.12M

Shares Short50.50K

Short Ratio1.68

3.66%

Short % of Float

3.07%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

0.67% Percentage of Shares held by All Insiders

38.13% Percentage of Shares held by All Institutions

38.39% Percentage of Float held by Institutions

Number of Institutions Holding Shares

Institutional Ownership

About 38.13% of LYRA shares are held by financial institutions. COMERICA BANK is the top corporate investor, holding 23 shares valued at $71.00. A 0% stake in Lyra Therapeutics, Inc. is owned by the company. BRYN MAWR TRUST CO owns 20 shares valued at $62.00, which translates its holding of 0% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	COMERICA BANK	0%	23	71	0	0
Dec 31, 2025	BRYN MAWR TRUST CO	0%	20	62	0	0
Dec 31, 2025	VANGUARD GROUP INC	0%	0	-	-28.75K	-100.00%
Dec 31, 2025	IFP ADVISORS, INC	0%	1	3	-1	-50.00%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0%	16	49	0	0
Dec 31, 2025	BANK OF AMERICA CORP /DE/	0.01%	201	619	183	+1,016.67%
Dec 31, 2025	TOWER RESEARCH CAPITAL LLC (TRC)	0.12%	2.19K	6.75K	1.66K	+310.30%
Dec 31, 2025	FORTITUDE FAMILY OFFICE, LLC	0%	0	-	-96	-100.00%
Dec 31, 2025	CITADEL ADVISORS LLC	0%	0	-	-19.48K	-100.00%
Dec 31, 2025	ARTIA GLOBAL PARTNERS LP	0.5%	8.76K	26.97K	8.76K	+100.00%
Dec 31, 2025	IKARIAN CAPITAL, LLC	1.2%	21.16K	65.18K	0	0
Dec 31, 2025	JPMORGAN CHASE & CO	0%	27	83	0	0
Dec 31, 2025	SABBY MANAGEMENT, LLC	9.91%	175.16K	539.49K	47.53K	+37.25%
Dec 31, 2025	ROYAL BANK OF CANADA	0.11%	1.95K	6K	628	+47.40%
Dec 31, 2025	BLACKROCK, INC.	0.14%	2.39K	7.37K	704	+41.66%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.69%	12.25K	37.73K	1.26K	+11.50%
Dec 31, 2025	DRW SECURITIES, LLC	0.95%	16.81K	51.78K	16.81K	+100.00%
Dec 31, 2025	SIGNATURE RESOURCES CAPITAL MANAGEMENT, LLC	0%	0	-	-400	-100.00%
Dec 31, 2025	PERCEPTIVE ADVISORS LLC	0%	0	-	-229.38K	-100.00%
Dec 31, 2025	FMR LLC	0%	0	-	-406	-100.00%
Dec 31, 2025	UBS GROUP AG	0.04%	675	2.08K	-3.33K	-83.13%
Dec 31, 2025	CITIGROUP INC	0%	3	9	-702	-99.57%
Dec 31, 2025	GLOBAL RETIREMENT PARTNERS, LLC	0%	15	46	15	+100.00%
Dec 31, 2025	ADVISOR GROUP HOLDINGS, INC.	0%	22	67	0	0
Dec 31, 2025	SBI SECURITIES CO., LTD.	0%	80	246	0	0
Dec 31, 2025	JONES FINANCIAL COMPANIES LLLP	0.01%	210	647	0	0
Dec 31, 2025	MORGAN STANLEY	0.02%	334	1.03K	-943	-73.84%
Dec 31, 2025	EVERSOURCE WEALTH ADVISORS, LLC	0.02%	338	1.04K	-7	-2.03%
Sep 30, 2025	CITADEL ADVISORS LLC	1.44%	19.48K	128.4K	19.48K	+100.00%
Sep 30, 2025	VANGUARD GROUP INC	2.13%	28.75K	189.49K	-424	-1.45%
Sep 30, 2025	SABBY MANAGEMENT, LLC	9.46%	127.62K	832.87K	1.9K	+1.51%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0%	18	117	-28.52K	-99.94%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0%	0	-	-39	-100.00%
Sep 30, 2025	PRINCIPAL SECURITIES, INC.	0%	0	-	-19	-100.00%
Sep 30, 2025	BRYN MAWR TRUST CO	0%	20	131	20	+100.00%
Sep 30, 2025	ADVISOR GROUP HOLDINGS, INC.	0%	22	143	22	+100.00%
Sep 30, 2025	COMERICA BANK	0%	23	150	0	0
Sep 30, 2025	JPMORGAN CHASE & CO	0%	27	178	-165	-85.94%
Sep 30, 2025	SBI SECURITIES CO., LTD.	0.01%	80	522	-5	-5.88%
Sep 30, 2025	FORTITUDE FAMILY OFFICE, LLC	0.01%	96	627	96	+100.00%
Sep 30, 2025	JONES FINANCIAL COMPANIES LLLP	0.02%	210	1.36K	200	+2,000.00%
Sep 30, 2025	EVERSOURCE WEALTH ADVISORS, LLC	0.03%	345	2.25K	-13	-3.63%
Sep 30, 2025	SIGNATURE RESOURCES CAPITAL MANAGEMENT, LLC	0.03%	400	2.61K	0	0
Sep 30, 2025	TOWER RESEARCH CAPITAL LLC (TRC)	0.04%	534	3.49K	-949	-63.99%
Sep 30, 2025	MORGAN STANLEY	0.09%	1.28K	8.34K	-887	-40.99%
Sep 30, 2025	ROYAL BANK OF CANADA	0.1%	1.33K	9K	223	+20.24%
Sep 30, 2025	IKARIAN CAPITAL, LLC	1.57%	21.16K	139.45K	0	0
Sep 30, 2025	PERCEPTIVE ADVISORS LLC	17.01%	229.38K	1.5M	-25.77K	-10.10%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0%	0	-	-1.59K	-100.00%
Sep 30, 2025	CWM, LLC	0%	0	-	-202	-100.00%
Sep 30, 2025	NISA INVESTMENT ADVISORS, LLC	0%	0	-	-10	-100.00%
Sep 30, 2025	STATE OF WISCONSIN INVESTMENT BOARD	0%	0	-	-10.5K	-100.00%
Sep 30, 2025	IFP ADVISORS, INC	0%	0	-	-300	-100.00%
Sep 30, 2025	VALLEY NATIONAL ADVISERS INC	0%	0	-	-500	-100.00%
Sep 30, 2025	RAYMOND JAMES FINANCIAL INC	0%	0	-	-8	-100.00%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0%	16	104	-9	-36.00%
Sep 30, 2025	FMR LLC	0.03%	406	2.68K	-1.34K	-76.77%
Sep 30, 2025	CITIGROUP INC	0.05%	705	4.65K	-90	-11.32%
Sep 30, 2025	BLACKROCK, INC.	0.13%	1.69K	11.03K	0	0
Sep 30, 2025	UBS GROUP AG	0.3%	4K	26.11K	4K	+199,950.00%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.81%	10.99K	72.41K	0	0
Jun 30, 2025	CWM, LLC	0.02%	202	2K	202	+100.00%
Jun 30, 2025	RAYMOND JAMES FINANCIAL INC	0%	8	72	8	+100.00%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0%	0	-	-370.19K	-100.00%
Jun 30, 2025	CITIGROUP INC	0%	0	-	-35.18K	-100.00%
Jun 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0%	0	-	-233.99K	-100.00%
Jun 30, 2025	JANE STREET GROUP, LLC	0%	0	-	-44K	-100.00%
Jun 30, 2025	SQUAREPOINT OPS LLC	0%	0	-	-15.28K	-100.00%
Jun 30, 2025	SASSICAIA CAPITAL ADVISERS LLC	0%	0	-	-10K	-100.00%
Jun 30, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0%	0	-	-29.02K	-100.00%
Jun 30, 2025	NISA INVESTMENT ADVISORS, LLC	0%	0	-	-500	-100.00%
Jun 30, 2025	ROYAL BANK OF CANADA	0%	0	-	-8.02K	-100.00%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0%	0	-	-111.61K	-100.00%
Jun 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0%	0	-	-154.8K	-100.00%
Jun 30, 2025	SIGNATURE RESOURCES CAPITAL MANAGEMENT, LLC	0.03%	400	3.58K	400	+100.00%
Jun 30, 2025	SBI SECURITIES CO., LTD.	0.01%	85	762	85	+100.00%
Jun 30, 2025	STATE STREET CORP	0%	0	-	-488.72K	-100.00%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0%	0	-	-17.54K	-100.00%
Jun 30, 2025	UBS GROUP AG	0%	2	18	2	+100.00%
Jun 30, 2025	PRINCIPAL SECURITIES, INC.	0%	19	170	19	+100.00%
Jun 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0%	25	224	25	+100.00%
Jun 30, 2025	WELLS FARGO & COMPANY/MN	0%	0	-	-25.31K	-100.00%
Jun 30, 2025	JPMORGAN CHASE & CO	0%	0	-	-56.28K	-100.00%
Jun 30, 2025	IFP ADVISORS, INC	0%	6	54	6	+100.00%
Jun 30, 2025	EVERSOURCE WEALTH ADVISORS, LLC	0.03%	358	3.21K	358	+100.00%
Jun 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.12%	1.59K	14.28K	1.59K	+100.00%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0%	0	-	-21.35K	-100.00%
Jun 30, 2025	TWO SIGMA ADVISERS, LP	0%	0	-	-364.48K	-100.00%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0%	0	-	-71.59K	-100.00%
Jun 30, 2025	PROSHARE ADVISORS LLC	0%	0	-	-10.48K	-100.00%
Jun 30, 2025	PERCEPTIVE ADVISORS LLC	18.92%	255.15K	2.29M	255.15K	+100.00%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.81%	10.99K	98.45K	10.99K	+100.00%
Jun 30, 2025	TWO SIGMA INVESTMENTS, LP	0%	0	-	-193.15K	-100.00%
Jun 30, 2025	NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO	0%	0	-	-6K	-100.00%
Jun 30, 2025	CIBC WORLD MARKETS CORP	0%	0	-	-10.74K	-100.00%
Jun 30, 2025	AMERITAS INVESTMENT PARTNERS, INC.	0%	0	-	-4.74K	-100.00%
Jun 30, 2025	SEI INVESTMENTS CO	0%	0	-	-30.07K	-100.00%
Jun 30, 2025	FMR LLC	0%	0	-	-58.21K	-100.00%
Jun 30, 2025	STERLING CAPITAL MANAGEMENT LLC	0%	0	-	-88	-100.00%
Jun 30, 2025	SG AMERICAS SECURITIES, LLC	0%	0	-	-14.62K	-100.00%
Jun 30, 2025	AQR CAPITAL MANAGEMENT LLC	0%	0	-	-58.04K	-100.00%
Jun 30, 2025	RHUMBLINE ADVISERS	0%	0	-	-87.71K	-100.00%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0%	0	-	-33.12K	-100.00%
Jun 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0%	0	-	-16.56K	-100.00%
Jun 30, 2025	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0%	0	-	-3.51K	-100.00%
Jun 30, 2025	NORTHERN TRUST CORP	0%	0	-	-332.64K	-100.00%
Jun 30, 2025	VALLEY NATIONAL ADVISERS INC	0.04%	500	4K	500	+100.00%
Jun 30, 2025	BLACKROCK, INC.	0.13%	1.69K	15.14K	1.69K	+100.00%
Jun 30, 2025	STATE OF WISCONSIN INVESTMENT BOARD	0.78%	10.5K	94.08K	10.5K	+100.00%
Jun 30, 2025	INVESCO LTD.	0%	0	-	-23.63K	-100.00%
Jun 30, 2025	COMERICA BANK	0%	0	-	-1.16K	-100.00%
Jun 30, 2025	BRYN MAWR TRUST CO	0%	0	-	-1.03K	-100.00%
Jun 30, 2025	MORGAN STANLEY	0%	0	-	-65.62K	-100.00%
Jun 30, 2025	JONES FINANCIAL COMPANIES LLLP	0%	0	-	-500	-100.00%
Jun 30, 2025	BARCLAYS PLC	0%	0	-	-50.04K	-100.00%
Jun 30, 2025	VANGUARD GROUP INC	0%	0	-	-1.77M	-100.00%
Jun 30, 2025	SAMSARA BIOCAPITAL, LLC	0%	0	-	-1.39M	-100.00%
Jun 30, 2025		0.01%	85	762	85	+100.00%
Jun 30, 2025	IKARIAN CAPITAL, LLC	1.57%	21.16K	189.6K	21.16K	+100.00%
Jun 30, 2025	SABBY MANAGEMENT, LLC	9.32%	125.73K	1.13M	125.73K	+100.00%
Jun 30, 2025	TOWER RESEARCH CAPITAL LLC (TRC)	0.11%	1.48K	13.29K	1.48K	+100.00%
Mar 31, 2025	COREBRIDGE FINANCIAL, INC.	0.04%	23.71K	2.99K	-352	-1.46%
Mar 31, 2025	CITIGROUP INC	0.05%	35.18K	4.44K	-2.93K	-7.68%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.29%	193.15K	24.39K	-16.85K	-8.02%
Mar 31, 2025	RHUMBLINE ADVISERS	0.13%	87.71K	11.05K	46.45K	+112.59%
Mar 31, 2025	MORGAN STANLEY	0.1%	65.62K	8.29K	-150.87K	-69.69%
Mar 31, 2025	SG AMERICAS SECURITIES, LLC	0.02%	14.62K	2K	-17.29K	-54.18%
Mar 31, 2025	CIBC WORLD MARKETS CORP	0.02%	10.74K	1.36K	10.74K	+100.00%
Mar 31, 2025	CITADEL ADVISORS LLC	0.05%	33.9K	4.28K	33.9K	+100.00%
Mar 31, 2025	SAMSARA BIOCAPITAL, LLC	2.11%	1.39M	175.57K	-575.56K	-29.28%
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.81%	533.2K	67.34K	0	0
Mar 31, 2025	STATE STREET CORP	0.74%	488.72K	61.73K	0	0
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.56%	370.19K	46.76K	-185.31K	-33.36%
Mar 31, 2025	TWO SIGMA ADVISERS, LP	0.55%	364.48K	46.03K	-21.02K	-5.45%
Mar 31, 2025	NORTHERN TRUST CORP	0.51%	332.64K	42.01K	46.33K	+16.18%
Mar 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.37%	242.55K	30.63K	-2.37K	-0.97%
Mar 31, 2025	FMR LLC	0.09%	58.21K	7.35K	-41.58K	-41.67%
Mar 31, 2025	ALLIANCEBERNSTEIN L.P.	0.05%	33.12K	4.18K	0	0
Mar 31, 2025	SEI INVESTMENTS CO	0.05%	30.07K	3.83K	-54.01K	-64.24%
Mar 31, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0.04%	29.02K	3.67K	1.25K	+4.49%
Mar 31, 2025	WELLS FARGO & COMPANY/MN	0.04%	25.31K	3.2K	561	+2.27%
Mar 31, 2025	INVESCO LTD.	0.04%	23.63K	2.98K	0	0
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.03%	21.35K	2.69K	-31.31K	-59.46%
Mar 31, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	16.56K	2.09K	16.56K	+100.00%
Mar 31, 2025	SQUAREPOINT OPS LLC	0.02%	15.28K	1.93K	15.28K	+100.00%
Mar 31, 2025		0.01%	4.27K	540	3	+0.07%
Mar 31, 2025	UBS GROUP AG	0.66%	434.23K	54.71K	9.26K	+2.18%
Mar 31, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.36%	233.99K	29.55K	0	0
Mar 31, 2025	ABEL HALL, LLC	0.02%	12.21K	1.54K	-5.43K	-30.79%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.33%	217.57K	27.48K	114.14K	+110.35%
Mar 31, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.24%	154.8K	20K	0	0
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.17%	111.61K	14.1K	0	0
Mar 31, 2025	AQR CAPITAL MANAGEMENT LLC	0.09%	58.04K	7.33K	29.33K	+102.14%
Mar 31, 2025	JPMORGAN CHASE & CO	0.09%	56.28K	7.11K	-100.17K	-64.03%
Mar 31, 2025	TOWER RESEARCH CAPITAL LLC (TRC)	0.08%	52.74K	6.66K	12.95K	+32.55%
Mar 31, 2025	BARCLAYS PLC	0.08%	50.04K	6K	-25.22K	-33.51%
Mar 31, 2025	PROSHARE ADVISORS LLC	0.02%	10.48K	1.32K	-3.15K	-23.14%
Mar 31, 2025	SASSICAIA CAPITAL ADVISERS LLC	0.02%	10K	1.26K	10K	+100.00%
Mar 31, 2025	ROYAL BANK OF CANADA	0.01%	8.02K	1K	2.73K	+51.47%
Mar 31, 2025	CWM, LLC	0.01%	6.68K	1K	1.31K	+24.32%
Mar 31, 2025	AMERITAS INVESTMENT PARTNERS, INC.	0.01%	4.74K	599	0	0
Mar 31, 2025	JANE STREET GROUP, LLC	0.07%	44K	5.56K	44K	+100.00%
Mar 31, 2025	NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO	0.01%	6K	758	6K	+100.00%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.11%	71.59K	9.04K	-4.38K	-5.77%
Mar 31, 2025	PERCEPTIVE ADVISORS LLC	19.4%	12.76M	1.61M	0	0
Mar 31, 2025	BLACKROCK, INC.	4.59%	3.02M	381.3K	-90.81K	-2.92%
Mar 31, 2025	VANGUARD GROUP INC	2.69%	1.77M	222.46K	-21.84K	-1.22%
Mar 31, 2025	IKARIAN CAPITAL, LLC	1.61%	1.06M	133.65K	0	0
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.55%	1.02M	128.34K	130.04K	+14.68%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.03%	17.54K	3K	0	0
Mar 31, 2024	WOODLINE PARTNERS LP	1.36%	676.55K	4.21M	76.58K	+12.76%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	0.72%	359.43K	2.24M	22.97K	+6.83%
Mar 31, 2024	ENSIGN PEAK ADVISORS, INC	1.19%	591.31K	3.68M	289.78K	+96.10%
Mar 31, 2024	PARKMAN HEALTHCARE PARTNERS LLC	1.29%	642.25K	3.99M	-112.64K	-14.92%
Mar 31, 2024	MAN GROUP PLC	0.18%	90.28K	561.56K	52.28K	+137.57%
Mar 31, 2024	LAURION CAPITAL MANAGEMENT LP	1.5%	747.83K	4.65M	705.4K	+1,662.75%
Mar 31, 2024	VERITION FUND MANAGEMENT LLC	1.54%	768.21K	4.78M	768.21K	+100.00%
Mar 31, 2024	VESTAL POINT CAPITAL, LP	1.61%	800K	4.98M	-2.2M	-73.33%
Mar 31, 2024	TRI LOCUM PARTNERS LP	1.97%	978.79K	6.09M	978.79K	+100.00%
Mar 31, 2024	ALLY BRIDGE GROUP (NY) LLC	2.02%	1M	6.24M	1M	+100.00%
Mar 31, 2024	IKARIAN CAPITAL, LLC	2.12%	1.06M	6.57M	-197.56K	-15.75%
Mar 31, 2024	ROSALIND ADVISORS, INC.	2.3%	1.14M	7.12M	-744.2K	-39.40%
Mar 31, 2024	PURA VIDA INVESTMENTS, LLC	2.84%	1.41M	8.79M	0	0
Mar 31, 2024	VANGUARD GROUP INC	2.97%	1.48M	9.21M	410.02K	+38.27%
Mar 31, 2024	VR ADVISER, LLC	5.17%	2.58M	16.02M	500	+0.02%
Mar 31, 2024	POINT72 ASSET MANAGEMENT, L.P.	5.51%	2.74M	17.06M	-257.54K	-8.58%
Mar 31, 2024	SAMSARA BIOCAPITAL, LLC	5.58%	2.78M	17.29M	0	0
Mar 31, 2024	NANTAHALA CAPITAL MANAGEMENT, LLC	5.66%	2.82M	17.55M	-1.23M	-30.35%
Mar 31, 2024	CITADEL ADVISORS LLC	8.71%	4.34M	26.99M	1.48M	+51.65%
Mar 31, 2024	PERCEPTIVE ADVISORS LLC	25.62%	12.76M	79.35M	0	0
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.37%	183.74K	1.14M	51.14K	+38.56%
Mar 31, 2024	SIMPLEX TRADING, LLC	0%	0	-	-1.17K	-100.00%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0%	0	-	-18.62K	-100.00%
Mar 31, 2024	GROUP ONE TRADING, L.P.	0%	0	-	-200	-100.00%
Mar 31, 2024	UBS GROUP AG	0%	18	112	-4.78K	-99.63%
Mar 31, 2024	WELLS FARGO & COMPANY/MN	0%	251	1.56K	4	+1.62%
Mar 31, 2024	RHUMBLINE ADVISERS	0%	296	1.84K	0	0
Mar 31, 2024	MACQUARIE GROUP LTD	0%	1.38K	9	1.38K	+100.00%
Mar 31, 2024	ADVISOR GROUP HOLDINGS, INC.	0%	2K	12.44K	0	0
Mar 31, 2024	NATIONAL BANK OF CANADA /FI/	0.01%	3.7K	1.39K	3.7K	+100.00%
Mar 31, 2024	HERITAGE WEALTH MANAGEMENT, INC./TEXAS	0.02%	10K	62.2K	0	0
Mar 31, 2024	JEFFERIES FINANCIAL GROUP INC.	0.02%	11.4K	70.91K	11.4K	+100.00%
Mar 31, 2024	DLK INVESTMENT MANAGEMENT, LLC	0.02%	12K	74.64K	0	0
Mar 31, 2024	BANK OF MONTREAL /CAN/	0.03%	13.9K	82.29K	13.9K	+100.00%
Mar 31, 2024	JUMP FINANCIAL, LLC	0.04%	20.19K	125.56K	3.45K	+20.61%
Mar 31, 2024	Y-INTERCEPT (HONG KONG) LTD	0.04%	20.53K	127.7K	8.25K	+67.20%
Mar 31, 2024	OMERS ADMINISTRATION CORP	0.04%	22.2K	138.08K	22.2K	+100.00%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.05%	25.78K	160.34K	25.78K	+100.00%
Mar 31, 2024	BALYASNY ASSET MANAGEMENT L.P.	0.06%	31.46K	195.68K	2.66K	+9.25%
Mar 31, 2024	LETKO, BROSSEAU & ASSOCIATES INC	0.06%	31.9K	198.42K	0	0
Mar 31, 2024	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.06%	32.12K	200K	3.07K	+10.58%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.1%	50.4K	313.49K	50.4K	+100.00%
Mar 31, 2024	CAMBRIDGE INVESTMENT RESEARCH ADVISORS, INC.	0.08%	41.56K	259K	41.56K	+100.00%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.1%	50.9K	317K	7K	+15.95%
Mar 31, 2024	INVESCO LTD.	1.11%	555.23K	3.45M	555.23K	+100.00%
Mar 31, 2024	JANE STREET GROUP, LLC	0.32%	157.7K	980.91K	79.45K	+101.53%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.67%	334.67K	2.08M	321.6K	+2,461.93%
Mar 31, 2024	NORTHERN TRUST CORP	0.12%	60.5K	376.28K	-1.05K	-1.71%
Mar 31, 2024	MORGAN STANLEY	0.13%	64.39K	400.52K	64.39K	+100.00%
Mar 31, 2024	MARATHON TRADING INVESTMENT MANAGEMENT LLC	0.13%	67.01K	416.8K	67.01K	+100.00%
Mar 31, 2024	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.17%	86.8K	539.9K	-55K	-38.79%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	0.82%	406.12K	2.53M	80.13K	+24.58%
Mar 31, 2024	WALLEYE CAPITAL LLC	1.06%	528.12K	3.28M	513.11K	+3,419.38%
Mar 31, 2024	HRT FINANCIAL LP	0.2%	98.53K	612K	98.53K	+100.00%
Mar 31, 2024	JPMORGAN CHASE & CO	0.22%	109.41K	680.5K	76.24K	+229.83%
Mar 31, 2024	CITIGROUP INC	0.24%	118.88K	739.4K	-5.57K	-4.47%
Mar 31, 2024	CLEARLINE CAPITAL LP	0.24%	119.13K	740.98K	0	0
Mar 31, 2024	STATE STREET CORP	0.25%	126.18K	784.84K	17K	+15.57%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.26%	131.9K	820.43K	76.45K	+137.88%
Mar 31, 2024	TWO SIGMA ADVISERS, LP	0.29%	143.9K	895.06K	93.2K	+183.83%
Mar 31, 2024	SUPERSTRING CAPITAL MANAGEMENT LP	0.29%	145.28K	903.67K	145.28K	+100.00%
Mar 31, 2024	BLACKROCK INC.	0.3%	151.92K	944.94K	41.12K	+37.11%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.32%	159.6K	992.69K	14.92K	+10.31%
Mar 31, 2024	ACUTA CAPITAL PARTNERS, LLC	0.35%	173.32K	1.08M	173.32K	+100.00%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	0.38%	190.99K	1.19M	78.35K	+69.56%
Mar 31, 2024	BOOTHBAY FUND MANAGEMENT, LLC	0.47%	232.67K	1.45M	-17.27K	-6.91%
Mar 31, 2024	ALYESKA INVESTMENT GROUP, L.P.	0.48%	240.72K	1.5M	0	0
Mar 31, 2024	HUDSON BAY CAPITAL MANAGEMENT LP	0.5%	250K	1.56M	250K	+100.00%
Mar 31, 2024	SCHONFELD STRATEGIC ADVISORS LLC	0.72%	357.32K	2.22M	315.61K	+756.61%
Dec 31, 2023	VR ADVISER, LLC	4.52%	2.58M	13.5M	1.65M	+178.69%
Dec 31, 2023	SAMSARA BIOCAPITAL, LLC	4.88%	2.78M	14.57M	0	0
Dec 31, 2023	CITADEL ADVISORS LLC	5.02%	2.86M	14.99M	12.69K	+0.45%
Dec 31, 2023	POINT72 ASSET MANAGEMENT, L.P.	5.27%	3M	15.72M	3M	+100.00%
Dec 31, 2023	NANTAHALA CAPITAL MANAGEMENT, LLC	7.11%	4.05M	21.22M	0	0
Dec 31, 2023	PERCEPTIVE ADVISORS LLC	22.4%	12.76M	66.85M	0	0
Dec 31, 2023	IKARIAN CAPITAL, LLC	2.2%	1.25M	6.57M	0	0
Dec 31, 2023	UBS GROUP AG	0.01%	4.8K	25.15K	4.78K	+26,566.67%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	0.2%	112.63K	590.2K	84.38K	+298.65%
Dec 31, 2023	CLEARLINE CAPITAL LP	0.21%	119.13K	624.23K	0	0
Dec 31, 2023	CITIGROUP INC	0.22%	124.44K	652.08K	56.77K	+83.88%
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	0.23%	132.61K	694.86K	116.19K	+707.59%
Dec 31, 2023	PURA VIDA INVESTMENTS, LLC	2.48%	1.41M	7.41M	0	0
Dec 31, 2023	ROSALIND ADVISORS, INC.	3.32%	1.89M	9.9M	1.89M	+100.00%
Dec 31, 2023	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.25%	141.8K	743.03K	0	0
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.25%	144.68K	758.11K	18.72K	+14.87%
Dec 31, 2023	ALYESKA INVESTMENT GROUP, L.P.	0.42%	240.72K	1.26M	0	0
Dec 31, 2023	BOOTHBAY FUND MANAGEMENT, LLC	0.44%	249.94K	1.31M	15.94K	+6.81%
Dec 31, 2023	ENSIGN PEAK ADVISORS, INC	0.53%	301.53K	1.58M	0	0
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	0.57%	326K	1.71M	62.65K	+23.79%
Dec 31, 2023	HERITAGE WEALTH MANAGEMENT, INC./TEXAS	0.02%	10K	52.4K	10K	+100.00%
Dec 31, 2023		0.02%	12K	62.88K	12K	+100.00%
Dec 31, 2023	Y-INTERCEPT (HONG KONG) LTD	0.02%	12.28K	64.34K	12.28K	+100.00%
Dec 31, 2023	TWO SIGMA SECURITIES, LLC	0.02%	12.77K	66.89K	12.77K	+100.00%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.02%	13.06K	68.45K	13.06K	+100.00%
Dec 31, 2023	WALLEYE CAPITAL LLC	0.03%	15.01K	78.63K	15.01K	+100.00%
Dec 31, 2023	JUMP FINANCIAL, LLC	0.03%	16.74K	87.7K	16.74K	+100.00%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.03%	18.62K	97.57K	0	0
Dec 31, 2023	BALYASNY ASSET MANAGEMENT L.P.	0.05%	28.8K	150.89K	28.8K	+100.00%
Dec 31, 2023	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.05%	29.05K	152K	29.05K	+100.00%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	0.59%	336.46K	1.76M	27.77K	+9.00%
Dec 31, 2023	WOODLINE PARTNERS LP	1.05%	599.98K	3.14M	599.98K	+100.00%
Dec 31, 2023	CUBIST SYSTEMATIC STRATEGIES, LLC	0.05%	29.63K	155.26K	29.63K	+100.00%
Dec 31, 2023	LETKO, BROSSEAU & ASSOCIATES INC	0.06%	31.9K	167.16K	0	0
Dec 31, 2023	PARKMAN HEALTHCARE PARTNERS LLC	1.33%	754.89K	3.96M	129.83K	+20.77%
Dec 31, 2023	BARCLAYS PLC	0.06%	32.82K	172K	32.82K	+100.00%
Dec 31, 2023	JPMORGAN CHASE & CO	0.06%	33.17K	173.81K	33.14K	+97,458.82%
Dec 31, 2023	MAN GROUP PLC	0.07%	38K	199.14K	38K	+100.00%
Dec 31, 2023	SCHONFELD STRATEGIC ADVISORS LLC	0.07%	41.71K	218.58K	41.71K	+100.00%
Dec 31, 2023	LAURION CAPITAL MANAGEMENT LP	0.07%	42.42K	222.3K	42.42K	+100.00%
Dec 31, 2023	RENAISSANCE TECHNOLOGIES LLC	0.08%	43.9K	230K	-5.9K	-11.85%
Dec 31, 2023	TWO SIGMA ADVISERS, LP	0.09%	50.7K	265.67K	50.7K	+100.00%
Dec 31, 2023	QUBE RESEARCH & TECHNOLOGIES LTD	0.1%	55.45K	290.55K	52.17K	+1,589.49%
Dec 31, 2023	NORTHERN TRUST CORP	0.11%	61.55K	322.52K	4.54K	+7.96%
Dec 31, 2023	683 CAPITAL MANAGEMENT, LLC	0.12%	69.87K	366.11K	69.87K	+100.00%
Dec 31, 2023	JANE STREET GROUP, LLC	0.14%	78.25K	410.04K	78.25K	+100.00%
Dec 31, 2023	STATE STREET CORP	0.19%	109.18K	572.1K	14.1K	+14.83%
Dec 31, 2023	BLACKROCK INC.	0.19%	110.8K	580.58K	63.32K	+133.35%
Dec 31, 2023	VANGUARD GROUP INC	1.88%	1.07M	5.61M	207.13K	+23.96%
Dec 31, 2023	ARMISTICE CAPITAL, LLC	1.91%	1.09M	5.7M	-462K	-29.81%

Insiders

Among the LYRA insiders holding of 0.67% of the stake in company, EDELMAN JOSEPH, , holds the largest shares of 7.86M. NORTH BRIDGE VENTURE MANAGEMENT VI, L.P., , is the second largest LYRA insider with ownership of 1.32M shares. PALASIS MARIA, President & CEO, stands third with possession of 1.1M shares of that stake.

Insiders	Designation	Shares Held
EDELMAN JOSEPH		7.86M
NORTH BRIDGE VENTURE MANAGEMENT VI, L.P.		1.32M
PALASIS MARIA	President & CEO	1.1M
CAVALIER JASON	Chief Financial Officer	518.55K
WAKSAL HARLAN	Executive Chair	261.97K
SOLEUS PRIVATE EQUITY GP I, LLC	10 percent owner	155K
NBVM GP, LLC	10 percent owner	98.97K
ANDERSON EDWARD T		98.97K
PERCEPTIVE ADVISORS LLC	10 percent owner	14.03K
MERRIFIELD C ANN		11.33K
POLARIS VENTURE MANAGEMENT CO. V, L.L.C.	10 percent owner	6.86K
SNYDERMAN NANCY LYNN MD	director	1.03K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Jan 06, 2026	PALASIS MARIA	SALE	3.36	1.7K	5.73K	1.1M
Jan 06, 2026	CAVALIER JASON	SALE	3.36	769	2.59K	518.55K
Nov 13, 2025	PERCEPTIVE ADVISORS LLC	SALE	3.90	3.21K	12.53K	14.03K
Nov 12, 2025	PERCEPTIVE ADVISORS LLC	SALE	4.06	883	3.58K	17.24K
Nov 11, 2025	PERCEPTIVE ADVISORS LLC	SALE	4.31	537	2.32K	18.12K
Nov 10, 2025	PERCEPTIVE ADVISORS LLC	SALE	4.54	1.87K	8.48K	18.66K
Nov 07, 2025	PERCEPTIVE ADVISORS LLC	SALE	4.75	1.99K	9.46K	20.53K
Nov 06, 2025	PERCEPTIVE ADVISORS LLC	SALE	5.18	3.25K	16.82K	22.52K
Jul 10, 2025	CAVALIER JASON	SALE	8.91	684	6.09K	519.32K
Jul 10, 2025	PALASIS MARIA	SALE	8.91	1.57K	13.94K	1.1M
Nov 10, 2023	WAKSAL HARLAN	PURCHASE	2.96	25K	74.1K	261.97K
May 31, 2023	NBVM GP, LLC	PURCHASE	2.67	98.97K	264.55K	98.97K
May 31, 2023	ANDERSON EDWARD T	PURCHASE	2.67	98.97K	264.55K	98.97K
May 31, 2023	PERCEPTIVE ADVISORS LLC	PURCHASE	2.67	1.81M	4.83M	1.81M
Jun 10, 2022	MERRIFIELD C ANN	PURCHASE	5.05	4K	20.2K	11.33K
May 13, 2022	MERRIFIELD C ANN	PURCHASE	4.81	3.5K	16.85K	7K
Apr 12, 2022	EDELMAN JOSEPH	PURCHASE	4.22	5.92M	25M	7.86M
Apr 12, 2022	WAKSAL HARLAN	PURCHASE	4.22	236.97K	1M	236.97K
Apr 12, 2022	NBVM GP, LLC	PURCHASE	4.22	527.81K	2.23M	909.42K
Apr 12, 2022	PERCEPTIVE ADVISORS LLC	PURCHASE	4.22	5.92M	25M	7.86M
Apr 12, 2022	NORTH BRIDGE VENTURE MANAGEMENT VI, L.P.	PURCHASE	4.22	765.01K	3.23M	1.32M
Apr 12, 2022	ANDERSON EDWARD T	PURCHASE	4.22	118.48K	500K	118.48K
Jun 17, 2021	MERRIFIELD C ANN	PURCHASE	8.97	3.5K	31.39K	3.5K
Dec 16, 2020	SNYDERMAN NANCY LYNN MD	PURCHASE	9.72	1.03K	9.96K	1.03K
May 05, 2020	POLARIS VENTURE MANAGEMENT CO. V, L.L.C.	SALE	16.00	64	1.02K	6.86K
May 05, 2020	ANDERSON EDWARD T	SALE	16.00	5.57K	89.09K	324.06K
May 05, 2020	SOLEUS PRIVATE EQUITY GP I, LLC	PURCHASE	16.00	155K	2.48M	155K
May 05, 2020	PERCEPTIVE ADVISORS LLC	PURCHASE	16.00	625K	10M	1.93M
May 05, 2020	NBVM GP, LLC	SALE	16.00	5.57K	89.09K	324.06K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES14.21K8

NET SHARES-14.21K8

SHARES HELD1.73M8

% NET SHARES-100.82%0%

Frequently Asked Questions