How many institutions own IRON stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own IRON shares is 220, representing 101.75% of the company's common stock.

Who are the major shareholders selling Disc Medicine, Inc. stock?

RAFFERTY ASSET MANAGEMENT, LLC, in the last quarter, reduced its stake in IRON by -3.24% restricting it's holding to 36.09 thousand shares of worth nearly $2.87M. CATALIO CAPITAL MANAGEMENT, LP also lessened -49% of the IRON shares from its portfolio, reducing its holding to 110.43 thousand shares of worth $8.77M. UBS GROUP AG also shunned IRON shares holding by -32.34% last quarter which brought its holding to 116.11 thousand shares worth $9.22M.

Investors who are buying IRON stock?

As per its latest 13F filing, RENAISSANCE TECHNOLOGIES LLC increased its stake in IRON by 823.82% in the last quarter. The institutional holder raised its holding to 62.82 thousand shares having worth more than $4.99M. SEVEN GRAND MANAGERS, LLC also added 100% more shares of IRON to its portfolio, raising its holding to 35 thousand shares of worth $2.78M. CITIGROUP INC also increased its IRON shares holding by 794.34% which brought its holding to 36.18 thousand shares worth $2.87M.

IRON's major insiders: who are they?

The insider with the most stakes in IRON is AI DMI LLC , 10 percent owner at the company. Additionally, IRON stock is highly held by Chief Executive Officer Quisel John D and 10 percent owner Atlas Venture Fund X, L.P. among others.

Did an insider recently sell IRON stock?

Company executives, directors, and other insiders own 10.61% percent of Disc Medicine, Inc.'s stock. Within the last six months, there have been 24 transaction(s) in which IRON insiders have sold stock, totaling 857.96K shares. Insiders that have sold shares include SAVAGE WILLIAM JACOB, FRANCHI JEAN M., and YU JONATHAN YEN-WEN.

Which insider recently purchased IRON stock?

There have been 0 transaction(s) during the past 6-months in which Disc Medicine, Inc. insiders have bought stock, totalling 0 shares

How much of IRON does insiders own?

Around 6.47M Disc Medicine, Inc. shares are held by insiders, which represents about 10.61% of IRON stock.

Who is the insider with the largest stake?

IRON 10 percent owner, AI DMI LLC holds the largest portfolio of the company's shares. IRON shares owned by AI total nearly 2.81 million.

Which institution holds the most shares in IRON?

RENAISSANCE TECHNOLOGIES LLC is the largest institutional owner in IRON which holds 62.82 thousand shares worth $4.99M or 0.18% of the total IRON shares outstanding followed by ENSIGN PEAK ADVISORS, INC with ownership of 177.05 thousand shares representing 0.5% of the IRON ownership. SEVEN GRAND MANAGERS, LLC is the third largest stakeholder with 35 thousand shares or 0.1% of the ownership worth more than $2.78M.

Is Disc Medicine, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the IRON is concerned, it is a stock which is optionable.

Is there a short position on IRON's shares?

Number of IRON shares short is 2.26M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding IRON shares are there?

As of today, 34.77M shares of IRON are outstanding.

Is there many float in IRON stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, IRON has 28.68M shares in float.

IRON short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for IRON is 6.54.

Disc Medicine (IRON) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares6.5

Short Percent Of Float7.24

Shares Outstanding34.77M

Shares Float28.68M

Shares Short2.26M

Short Ratio6.54

7.24%

Short % of Float

6.5%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

10.61% Percentage of Shares held by All Insiders

101.75% Percentage of Shares held by All Institutions

113.83% Percentage of Float held by Institutions

220

Number of Institutions Holding Shares

Institutional Ownership

About 101.75% of IRON shares are held by financial institutions. RENAISSANCE TECHNOLOGIES LLC is the top corporate investor, holding 62.82K shares valued at $4.99M. A 0.18% stake in Disc Medicine, Inc. is owned by the company. ENSIGN PEAK ADVISORS, INC owns 177.05K shares valued at $14.06M, which translates its holding of 0.5% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.18%	62.82K	4.99M	56.02K	+823.82%
Dec 31, 2025	ENSIGN PEAK ADVISORS, INC	0.5%	177.05K	14.06M	0	0
Dec 31, 2025	SEVEN GRAND MANAGERS, LLC	0.1%	35K	2.78M	35K	+100.00%
Dec 31, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.1%	36.09K	2.87M	-1.21K	-3.24%
Dec 31, 2025	CITIGROUP INC	0.1%	36.18K	2.87M	32.13K	+794.34%
Dec 31, 2025	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	0.11%	40.2K	3.19M	39.99K	+18,774.65%
Dec 31, 2025		0.12%	42.78K	3.4B	42.78K	+100.00%
Dec 31, 2025	STATE STREET CORP	3.38%	1.19M	94.34M	142.39K	+13.62%
Dec 31, 2025	JPMORGAN CHASE & CO	4.49%	1.58M	125.56M	828.25K	+110.01%
Dec 31, 2025	VANGUARD GROUP INC	5.02%	1.77M	140.37M	319.62K	+22.07%
Dec 31, 2025	BLACKROCK, INC.	6.47%	2.27M	180.66M	255.7K	+12.66%
Dec 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	4.32%	1.52M	120.57M	108.2K	+7.67%
Dec 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	4.83%	1.7M	134.84M	371.58K	+28.01%
Dec 31, 2025	RA CAPITAL MANAGEMENT, L.P.	5.62%	1.98M	156.92M	399.03K	+25.30%
Dec 31, 2025	CATALIO CAPITAL MANAGEMENT, LP	0.31%	110.43K	8.77M	-106.1K	-49.00%
Dec 31, 2025	SOFINNOVA INVESTMENTS, INC.	0.32%	111.01K	8.82M	97.46K	+719.08%
Dec 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.33%	114.35K	9.08M	22.97K	+25.14%
Dec 31, 2025	UBS GROUP AG	0.33%	116.11K	9.22M	-55.51K	-32.34%
Dec 31, 2025	LOGOS GLOBAL MANAGEMENT LP	1.45%	510K	40.5M	60K	+13.33%
Dec 31, 2025	VESTAL POINT CAPITAL, LP	2.09%	735K	58.37M	235K	+47.00%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	2.14%	754.2K	59.89M	225.11K	+42.55%
Dec 31, 2025	WOODLINE PARTNERS LP	2.72%	957.83K	76.06M	90.88K	+10.48%
Dec 31, 2025	SIREN, L.L.C.	2.81%	988.4K	78.49M	75K	+8.21%
Dec 31, 2025	ORBIMED ADVISORS LLC	3.03%	1.07M	84.77M	-347.47K	-24.56%
Dec 31, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	3.58%	1.26M	100.06M	-178.53K	-12.41%
Dec 31, 2025	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	4.3%	1.51M	120.22M	-628.74K	-29.34%
Dec 31, 2025	FMR LLC	15.49%	5.45M	432.8M	515.06K	+10.44%
Dec 31, 2025	MORGAN STANLEY	0.21%	74.83K	5.94M	18.75K	+33.44%
Dec 31, 2025	RAYMOND JAMES FINANCIAL INC	0.23%	80.27K	6.18M	-61.21K	-43.26%
Dec 31, 2025	DNB ASSET MANAGEMENT AS	0.24%	84.26K	6.69M	78.73K	+1,425.81%
Dec 31, 2025	BARCLAYS PLC	0.28%	99.61K	7.91M	-7.59K	-7.08%
Dec 31, 2025	CITADEL ADVISORS LLC	0.29%	100.4K	7.97B	50K	+99.22%
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	0.53%	184.78K	14.67M	23.78K	+14.77%
Dec 31, 2025	TIMESSQUARE CAPITAL MANAGEMENT, LLC	0.53%	187.78K	14.91M	5.61K	+3.08%
Dec 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.64%	223.58K	17.75M	-6.85K	-2.97%
Dec 31, 2025	ABRDN PLC	0.67%	234.36K	18.61M	202.3K	+630.98%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.7%	247.04K	19.62M	20.38K	+8.99%
Dec 31, 2025	ALPS ADVISORS INC	0.09%	31K	2.46M	14.21K	+84.62%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.09%	33.27K	2.64M	6.21K	+22.95%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.35%	122.15K	9.7M	84.54K	+224.79%
Dec 31, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	0.38%	132.8K	10.55M	-155K	-53.86%
Dec 31, 2025	OPALEYE MANAGEMENT INC.	0.57%	200K	15.88M	6.23K	+3.21%
Dec 31, 2025	PALO ALTO INVESTORS LP	0.9%	317.46K	25.21M	93.16K	+41.53%
Dec 31, 2025	BAKER BROS. ADVISORS LP	0.96%	337.05K	26.77M	0	0
Dec 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.12%	394.37K	31.32M	390.81K	+10,968.59%
Dec 31, 2025	EVENTIDE ASSET MANAGEMENT, LLC	1.12%	395.39K	31.4M	87.35K	+28.36%
Dec 31, 2025	PERCEPTIVE ADVISORS LLC	1.28%	450.74K	35.79M	450.74K	+100.00%
Dec 31, 2025	CHECKPOINT CAPITAL L.P.	1.29%	452.99K	35.97M	22.99K	+5.35%
Dec 31, 2025	ARMISTICE CAPITAL, LLC	1.42%	499.39K	39.66M	63.39K	+14.54%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	0.39%	135.99K	10.8M	-25.2K	-15.63%
Dec 31, 2025	FIRST TURN MANAGEMENT, LLC	0.44%	153.21K	12.17M	-244.49K	-61.48%
Dec 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.63%	221.76K	17.61M	-116.34K	-34.41%
Dec 31, 2025	NORTHERN TRUST CORP	0.65%	228.07K	18.11M	8.58K	+3.91%
Dec 31, 2025	ASSENAGON ASSET MANAGEMENT S.A.	1.02%	357.84K	28.42M	347.4K	+3,329.85%
Dec 31, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.45%	511.16K	40.59M	-408.24K	-44.40%
Dec 31, 2025	FIRST LIGHT ASSET MANAGEMENT, LLC	1.49%	523.17K	41.54M	291.98K	+126.30%
Dec 31, 2025	BVF INC/IL	1.85%	650K	51.62M	650K	+100.00%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.95%	684.96K	54.4M	56.81K	+9.04%
Dec 31, 2025	LOOMIS SAYLES & CO L P	0.8%	282.41K	22.43M	282.41K	+100.00%
Dec 31, 2025	EXOME ASSET MANAGEMENT LLC	0.13%	46.74K	3.71M	-14.61K	-23.82%
Dec 31, 2025	HEALTHINVEST PARTNERS AB	0.14%	47.97K	3.81M	2.28K	+4.98%
Dec 31, 2025	JENNISON ASSOCIATES LLC	1.51%	532.08K	42.25M	532.08K	+100.00%
Dec 31, 2025	FORESITE CAPITAL MANAGEMENT V, LLC	0.85%	299.07K	23.75M	0	0
Dec 31, 2025	SATURN V CAPITAL MANAGEMENT LLC	0.85%	298.43K	23.7M	-42.47K	-12.46%
Dec 31, 2025	GREAT POINT PARTNERS LLC	0.71%	250K	19.85M	250K	+100.00%
Dec 31, 2025	SWISS NATIONAL BANK	0.14%	48K	3.81M	4.4K	+10.09%
Dec 31, 2025	NICHOLAS INVESTMENT PARTNERS, LP	0.14%	48.08K	3.82M	-39.92K	-45.36%
Dec 31, 2025	NUVEEN, LLC	0.14%	48.47K	3.85M	777	+1.63%
Dec 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.14%	50K	3.97M	50K	+100.00%
Dec 31, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.14%	50.1K	3.85M	-17.09K	-25.44%
Dec 31, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.15%	52.51K	4.07M	4.93K	+10.37%
Dec 31, 2025	VICTORY CAPITAL MANAGEMENT INC	0.22%	76.34K	6.06M	-73.53K	-49.06%
Dec 31, 2025	PATIENT SQUARE CAPITAL LP	0.21%	74K	5.88M	0	0
Dec 31, 2025	TD ASSET MANAGEMENT INC	0.2%	69.63K	5.53M	10.39K	+17.53%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.19%	67.71K	5.38M	2.91K	+4.49%
Dec 31, 2025	IA GLOBAL ASSET MANAGEMENT INC.	0.19%	66.43K	5.28M	918	+1.40%
Dec 31, 2025	TUDOR INVESTMENT CORP ET AL	0.19%	66.13K	5.25M	66.13K	+100.00%
Dec 31, 2025	VERITION FUND MANAGEMENT LLC	0.18%	63.54K	5.05M	57.4K	+935.95%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.11%	37.61K	2.49M	32.91K	+699.70%
Sep 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	1.33%	465.26K	30.74M	0	0
Sep 30, 2025	FMR LLC	14.09%	4.94M	326.12M	1.69M	+52.05%
Sep 30, 2025	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	6.12%	2.14M	141.58M	-241.84K	-10.14%
Sep 30, 2025	BLACKROCK, INC.	5.77%	2.02M	133.43M	-25.54K	-1.25%
Sep 30, 2025	VANGUARD GROUP INC	4.13%	1.45M	95.69M	51.32K	+3.67%
Sep 30, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	4.11%	1.44M	95.06M	-216.3K	-13.07%
Sep 30, 2025	ORBIMED ADVISORS LLC	4.04%	1.42M	93.5M	0	0
Sep 30, 2025	FIRST TURN MANAGEMENT, LLC	1.14%	397.69K	26.28M	98.23K	+32.80%
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	4.5%	1.58M	104.22M	0	0
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	4.03%	1.41M	93.18M	-22.01K	-1.54%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	3.79%	1.33M	87.65M	-189.2K	-12.48%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.19%	64.8K	4.28M	-6.7K	-9.37%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.17%	59.25K	3.92M	6.2K	+11.69%
Sep 30, 2025	NUVEEN, LLC	0.14%	47.69K	3.15M	-2.58K	-5.12%
Sep 30, 2025	HEALTHINVEST PARTNERS AB	0.13%	45.69K	320.53K	21.04K	+85.34%
Sep 30, 2025	SWISS NATIONAL BANK	0.12%	43.6K	2.88M	700	+1.63%
Sep 30, 2025	Y-INTERCEPT (HONG KONG) LTD	0.12%	43.29K	2.86M	33.91K	+361.38%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.11%	37.3K	2.46M	5.81K	+18.46%
Sep 30, 2025	RHUMBLINE ADVISERS	0.1%	34.49K	2.28M	-1.27K	-3.54%
Sep 30, 2025	ABRDN PLC	0.09%	32.06K	2.12M	0	0
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.08%	27.94K	1.85M	27.94K	+100.00%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.08%	27.06K	1.79M	4.59K	+20.45%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.07%	25.15K	1.66M	1.05K	+4.36%
Sep 30, 2025	PNC FINANCIAL SERVICES GROUP, INC.	0.07%	25.15K	1.66M	6	+0.02%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.06%	21.49K	1.42M	4.64K	+27.52%
Sep 30, 2025	INVESCO LTD.	0.06%	21.44K	1.42M	4.63K	+27.51%
Sep 30, 2025	DEUTSCHE BANK AG\	0.05%	18.89K	1.25M	2.17K	+12.97%
Sep 30, 2025	BANK OF MONTREAL /CAN/	0.05%	17.79K	1.18M	6.8K	+61.86%
Sep 30, 2025	ALPS ADVISORS INC	0.05%	16.79K	1.11M	-1.83K	-9.85%
Sep 30, 2025	MARSHALL WACE, LLP	0.04%	14K	925.19K	14K	+100.00%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	13.92K	919.97K	-932	-6.27%
Sep 30, 2025	TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY	0.04%	12.85K	849K	0	0
Sep 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.03%	11.44K	755.82K	4.06K	+55.07%
Sep 30, 2025	LEGATO CAPITAL MANAGEMENT LLC	0.03%	11.29K	745.85K	4.06K	+56.16%
Sep 30, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.03%	10.43K	689.41K	10.43K	+100.00%
Sep 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.03%	9.03K	596.57K	9.03K	+100.00%
Sep 30, 2025	PROFUND ADVISORS LLC	0.02%	8.12K	536.44K	1.4K	+20.91%
Sep 30, 2025	SG AMERICAS SECURITIES, LLC	0.02%	8.06K	533K	8.06K	+100.00%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.02%	8.01K	529.04K	-4.22K	-34.50%
Sep 30, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	7.09K	468.77K	138	+1.98%
Sep 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	2.63%	919.4K	60.75M	0	0
Sep 30, 2025	SIREN, L.L.C.	2.61%	913.4K	60.36M	-186K	-16.92%
Sep 30, 2025	LOGOS GLOBAL MANAGEMENT LP	1.28%	450K	29.74M	-250K	-35.71%
Sep 30, 2025	ARMISTICE CAPITAL, LLC	1.24%	436K	28.81M	0	0
Sep 30, 2025	CHECKPOINT CAPITAL L.P.	1.23%	430K	28.41M	165K	+62.26%
Sep 30, 2025	JANUS HENDERSON GROUP PLC	1.03%	361.7K	23.9M	-1.19M	-76.72%
Sep 30, 2025	SATURN V CAPITAL MANAGEMENT LLC	0.97%	340.9K	22.53M	-55.22K	-13.94%
Sep 30, 2025	FORESITE CAPITAL MANAGEMENT V, LLC	0.85%	299.07K	19.76M	0	0
Sep 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	0.82%	287.8K	19.02M	0	0
Sep 30, 2025	SIO CAPITAL MANAGEMENT, LLC	0.81%	284.79K	18.82M	0	0
Sep 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	0.71%	247.72K	16.37M	-963.26K	-79.54%
Sep 30, 2025	FIRST LIGHT ASSET MANAGEMENT, LLC	0.66%	231.19K	15.28M	231.19K	+100.00%
Sep 30, 2025	CATALIO CAPITAL MANAGEMENT, LP	0.62%	216.53K	14.31M	185.87K	+606.20%
Sep 30, 2025	OPALEYE MANAGEMENT INC.	0.55%	193.77K	12.8M	7.36K	+3.95%
Sep 30, 2025	TIMESSQUARE CAPITAL MANAGEMENT, LLC	0.52%	182.17K	12.04M	182.17K	+100.00%
Sep 30, 2025	ENSIGN PEAK ADVISORS, INC	0.51%	177.05K	11.7M	35.51K	+25.08%
Sep 30, 2025	UBS GROUP AG	0.49%	171.62K	11.34M	26.07K	+17.91%
Sep 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.43%	149.86K	9.9M	-47.96K	-24.24%
Sep 30, 2025	RAYMOND JAMES FINANCIAL INC	0.4%	141.48K	9.35M	54.99K	+63.58%
Sep 30, 2025	BARCLAYS PLC	0.31%	107.2K	7.08M	20.65K	+23.85%
Sep 30, 2025	BLUE OWL CAPITAL HOLDINGS LP	0.29%	102.26K	6.76M	-20K	-16.36%
Sep 30, 2025	WOODLINE PARTNERS LP	2.48%	866.96K	57.29M	0	0
Sep 30, 2025	JPMORGAN CHASE & CO	2.15%	752.88K	49.75M	-90.74K	-10.76%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.79%	628.15K	41.52M	29.56K	+4.94%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.66%	230.42K	15.22M	37.57K	+19.48%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.65%	226.66K	14.98M	22.41K	+10.97%
Sep 30, 2025	PALO ALTO INVESTORS LP	0.64%	224.3K	14.82M	78.61K	+53.96%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.97%	338.1K	22.34M	338.1K	+100.00%
Sep 30, 2025	BAKER BROS. ADVISORS LP	0.96%	337.05K	22.27M	0	0
Sep 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	0.88%	308.04K	20.36M	13	0.00%
Sep 30, 2025	NORTHERN TRUST CORP	0.63%	219.49K	14.5M	394	+0.18%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.46%	161.18K	10.65M	-7.64K	-4.52%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.46%	161K	10.64M	139.41K	+645.61%
Sep 30, 2025	STATE STREET CORP	2.99%	1.05M	69.09M	115.83K	+12.46%
Sep 30, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.29%	102.19K	6.75M	102.19K	+100.00%
Sep 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.26%	91.38K	6.04M	-30.2K	-24.84%
Sep 30, 2025	ZIMMER PARTNERS, LP	0.26%	90.16K	5.96M	0	0
Sep 30, 2025	NICHOLAS INVESTMENT PARTNERS, LP	0.25%	88K	5.82M	33.56K	+61.64%
Sep 30, 2025	AMERIPRISE FINANCIAL INC	0.21%	74.35K	4.91B	-47.17K	-38.82%
Sep 30, 2025	PATIENT SQUARE CAPITAL LP	0.21%	74K	4.89M	0	0
Sep 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.19%	67.2K	4.37M	-15.26K	-18.50%
Sep 30, 2025	IA GLOBAL ASSET MANAGEMENT INC.	0.19%	65.51K	4.33M	65.19K	+20,245.34%
Sep 30, 2025	VESTAL POINT CAPITAL, LP	1.43%	500K	33.04M	360K	+257.14%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.28%	450K	29.74M	0	0
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.51%	529.08K	34.96M	303.23K	+134.26%
Jun 30, 2025	JPMORGAN CHASE & CO	2.41%	843.62K	44.68M	84.28K	+11.10%
Jun 30, 2025	ARMISTICE CAPITAL, LLC	1.24%	436K	23.09M	0	0
Jun 30, 2025	CAPTION MANAGEMENT, LLC	1.22%	426.3K	22.58M	407.2K	+2,131.94%
Jun 30, 2025	SATURN V CAPITAL MANAGEMENT LLC	1.13%	396.12K	20.98M	-122.06K	-23.56%
Jun 30, 2025	ENSIGN PEAK ADVISORS, INC	0.4%	141.55K	7.5M	69.03K	+95.20%
Jun 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.35%	121.58K	6.44M	25.03K	+25.92%
Jun 30, 2025	AMERIPRISE FINANCIAL INC	0.35%	121.52K	6.44M	53.62K	+78.96%
Jun 30, 2025	MORGAN STANLEY	0.32%	110.68K	5.86M	-59.53K	-34.98%
Jun 30, 2025	WOODLINE PARTNERS LP	2.48%	866.96K	45.91M	364.73K	+72.62%
Jun 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	0.88%	308.03K	16.31M	126.21K	+69.42%
Jun 30, 2025	FIRST TURN MANAGEMENT, LLC	0.86%	299.46K	15.86M	299.46K	+100.00%
Jun 30, 2025	CHECKPOINT CAPITAL L.P.	0.76%	265K	14.03M	21.69K	+8.91%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.48%	168.82K	8.94M	115.01K	+213.75%
Jun 30, 2025	PALO ALTO INVESTORS LP	0.42%	145.69K	7.72M	145.69K	+100.00%
Jun 30, 2025	ZIMMER PARTNERS, LP	0.26%	90.16K	4.78M	47.26K	+110.17%
Jun 30, 2025	BARCLAYS PLC	0.25%	86.56K	4.59M	40.85K	+89.37%
Jun 30, 2025	RAYMOND JAMES FINANCIAL INC	0.25%	86.49K	4.58M	3.21K	+3.86%
Jun 30, 2025	OPALEYE MANAGEMENT INC.	0.53%	186.42K	9.87M	101.42K	+119.32%
Jun 30, 2025	BLUE OWL CAPITAL HOLDINGS LP	0.35%	122.26K	6.47M	-18K	-12.83%
Jun 30, 2025	BAKER BROS. ADVISORS LP	0.96%	337.05K	17.85M	260K	+337.44%
Jun 30, 2025	FMR LLC	9.27%	3.25M	171.89M	21.33K	+0.66%
Jun 30, 2025	SIO CAPITAL MANAGEMENT, LLC	0.81%	284.79K	15.08M	211.28K	+287.41%
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.28%	96.42K	5.11M	-94.8K	-49.58%
Jun 30, 2025	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	6.81%	2.38M	126.28M	0	0
Jun 30, 2025	JANUS HENDERSON GROUP PLC	4.44%	1.55M	82.25M	130.7K	+9.18%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	4.33%	1.52M	80.27M	157.37K	+11.59%
Jun 30, 2025	UBS GROUP AG	0.42%	145.55K	7.71M	72.92K	+100.40%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.71%	598.59K	31.71M	26.61K	+4.65%
Jun 30, 2025	LOGOS GLOBAL MANAGEMENT LP	2%	700K	37.07M	305.66K	+77.51%
Jun 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	0.82%	287.8K	15.24M	139.41K	+93.95%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.28%	450K	23.83M	150K	+50.00%
Jun 30, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0.04%	15.04K	798.94K	-97	-0.64%
Jun 30, 2025	PRELUDE CAPITAL MANAGEMENT, LLC	0.05%	18.16K	961.54K	-44	-0.24%
Jun 30, 2025	FORESITE CAPITAL MANAGEMENT V, LLC	0.85%	299.07K	15.84M	0	0
Jun 30, 2025	ALPS ADVISORS INC	0.05%	18.63K	986.43K	-6.85K	-26.90%
Jun 30, 2025	TD ASSET MANAGEMENT INC	0.15%	53.05K	2.81M	10.6K	+24.97%
Jun 30, 2025	NICHOLAS INVESTMENT PARTNERS, LP	0.16%	54.45K	2.88M	54.45K	+100.00%
Jun 30, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.17%	57.95K	3.07M	44.38K	+327.17%
Jun 30, 2025	EXOME ASSET MANAGEMENT LLC	0.18%	61.36K	3.25M	-300	-0.49%
Jun 30, 2025	PATIENT SQUARE CAPITAL LP	0.21%	74K	3.92M	-9K	-10.84%
Jun 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.24%	82.45K	4.49M	-4.84K	-5.54%
Jun 30, 2025	VESTAL POINT CAPITAL, LP	0.4%	140K	7.41M	140K	+100.00%
Jun 30, 2025	BLACKROCK, INC.	5.84%	2.04M	108.29M	-49.73K	-2.37%
Jun 30, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	4.72%	1.65M	87.64M	-100K	-5.70%
Jun 30, 2025	VANGUARD GROUP INC	3.99%	1.4M	73.97M	91.69K	+7.03%
Jun 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	3.46%	1.21M	64.13M	0	0
Jun 30, 2025	SIREN, L.L.C.	3.14%	1.1M	58.22M	27.54K	+2.57%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.64%	225.86K	11.96M	95.11K	+72.74%
Jun 30, 2025	NORTHERN TRUST CORP	0.63%	219.1K	11.6M	10.28K	+4.92%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.58%	204.24K	10.82M	9.52K	+4.89%
Jun 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.56%	197.82K	10.48M	4.16K	+2.15%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.55%	192.86K	10.22M	53.46K	+38.35%
Jun 30, 2025	ORBIMED ADVISORS LLC	4.04%	1.42M	74.94M	0	0
Jun 30, 2025	STATE STREET CORP	2.65%	929.77K	49.24M	11.2K	+1.22%
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	4.5%	1.58M	83.52M	0	0
Jun 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	2.63%	919.4K	48.69M	137.07K	+17.52%
Jun 30, 2025	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	1.67%	583.5K	30.9M	-400K	-40.67%
Jun 30, 2025		0.09%	30.66K	1.62M	30.66K	+100.00%
Jun 30, 2025	ABRDN PLC	0.09%	32.06K	1.7M	32.06K	+100.00%
Jun 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.09%	31.49K	1.67M	-2.55K	-7.50%
Jun 30, 2025	PFM HEALTH SCIENCES, LP	0.09%	30.8K	1.63M	30.8K	+100.00%
Jun 30, 2025	BOLLARD GROUP LLC	0.09%	30.64K	1.62M	30.64K	+100.00%
Jun 30, 2025	HEALTHINVEST PARTNERS AB	0.07%	24.65K	1.31M	24.65K	+100.00%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.07%	24.14K	1.28B	3.08K	+14.62%
Jun 30, 2025	ROYAL BANK OF CANADA	0.06%	22.6K	1.2M	21.4K	+1,786.39%
Jun 30, 2025	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0.06%	20.25K	1.07B	98	+0.49%
Jun 30, 2025	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.06%	19.73K	1.04M	19.73K	+100.00%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	4.09%	1.43M	75.84M	-911.41K	-38.89%
Jun 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	1.33%	465.26K	24.64M	0	0
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	4.73%	1.58M	78.29M	1.58M	+100.00%
Mar 31, 2025	ENSIGN PEAK ADVISORS, INC	0.22%	72.51K	3.6M	32.51K	+81.28%
Mar 31, 2025	UBS GROUP AG	0.22%	72.63K	3.61M	48.29K	+198.37%
Mar 31, 2025	SIO CAPITAL MANAGEMENT, LLC	0.22%	73.51K	3.65M	0	0
Mar 31, 2025	BAKER BROS. ADVISORS LP	0.23%	77.05K	3.82M	0	0
Mar 31, 2025	OPALEYE MANAGEMENT INC.	0.26%	85K	4.22M	85K	+100.00%
Mar 31, 2025	NORTHERN TRUST CORP	0.63%	208.81K	10.37M	21.8K	+11.65%
Mar 31, 2025	D. E. SHAW & CO., INC.	0.66%	219.6K	10.9M	138.41K	+170.48%
Mar 31, 2025	SATURN V CAPITAL MANAGEMENT LLC	1.55%	518.18K	25.72M	8.77K	+1.72%
Mar 31, 2025	PERCEPTIVE ADVISORS LLC	0.45%	150K	7.45M	150K	+100.00%
Mar 31, 2025	EVENTIDE ASSET MANAGEMENT, LLC	0.55%	181.82K	9.03M	181.82K	+100.00%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.57%	191.22K	9.49M	104.8K	+121.27%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.33%	108.5K	5.39M	100.62K	+1,277.07%
Mar 31, 2025	ARMISTICE CAPITAL, LLC	1.31%	436K	21.64M	80K	+22.47%
Mar 31, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	5.27%	1.75M	87.11M	0	0
Mar 31, 2025	BLACKROCK, INC.	6.29%	2.09M	103.97M	234.83K	+12.63%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	7.03%	2.34M	116.33M	948.09K	+67.94%
Mar 31, 2025	FMR LLC	9.68%	3.22M	160.06M	1.36M	+72.77%
Mar 31, 2025	TCG CROSSOVER MANAGEMENT, LLC	1.4%	465.26K	23.1M	-21.7K	-4.46%
Mar 31, 2025	WOODLINE PARTNERS LP	1.51%	502.23K	24.93M	105.63K	+26.63%
Mar 31, 2025	PATIENT SQUARE CAPITAL LP	0.25%	83K	4.12M	26.6K	+47.16%
Mar 31, 2025	RAYMOND JAMES FINANCIAL INC	0.25%	83.28K	4.13M	-4.73K	-5.37%
Mar 31, 2025	SIREN, L.L.C.	3.22%	1.07M	53.21M	1.07M	+100.00%
Mar 31, 2025	PARADIGM BIOCAPITAL ADVISORS LP	3.63%	1.21M	60.11M	-286.75K	-19.15%
Mar 31, 2025	SUVRETTA CAPITAL MANAGEMENT, LLC	0.24%	80K	3.97M	80K	+100.00%
Mar 31, 2025	CHECKPOINT CAPITAL L.P.	0.73%	243.31K	12.08M	58.31K	+31.52%
Mar 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.39%	130.39K	6.47M	904	+0.70%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.39%	130.75K	6.49M	-41.06K	-23.90%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.42%	139.39K	6.92M	-327	-0.23%
Mar 31, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.71%	236.47K	11.74M	126.09K	+114.23%
Mar 31, 2025	FORESITE CAPITAL MANAGEMENT V, LLC	0.9%	299.07K	14.85M	0	0
Mar 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.9%	300K	14.89M	-50K	-14.29%
Mar 31, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.26%	87.29K	4.57M	-4.2K	-4.59%
Mar 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.29%	96.56K	4.79M	3.45K	+3.71%
Mar 31, 2025	BLUE OWL CAPITAL HOLDINGS LP	0.42%	140.26K	6.96M	20K	+16.63%
Mar 31, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	0.45%	148.39K	7.37M	-1.61K	-1.07%
Mar 31, 2025	MORGAN STANLEY	0.51%	170.21K	8.45M	20.19K	+13.46%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.72%	571.98K	28.4M	99.28K	+21.00%
Mar 31, 2025	JPMORGAN CHASE & CO	2.28%	759.34K	37.69M	698.32K	+1,144.47%
Mar 31, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	2.35%	782.33K	38.84M	181.82K	+30.28%
Mar 31, 2025	STATE STREET CORP	2.76%	918.57K	45.6M	149.83K	+19.49%
Mar 31, 2025	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	2.95%	983.5K	48.82M	0	0
Mar 31, 2025	VANGUARD GROUP INC	3.92%	1.31M	64.78M	236.8K	+22.17%
Mar 31, 2025		0.34%	112.72K	5.6M	112.72K	+100.00%
Mar 31, 2025	VICTORY CAPITAL MANAGEMENT INC	0.58%	193.66K	9.61M	-42.58K	-18.02%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.58%	194.73K	9.67M	29.65K	+17.96%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	4.08%	1.36M	67.43M	-36.38K	-2.61%
Mar 31, 2025	ORBIMED ADVISORS LLC	4.25%	1.42M	70.24M	-370.55K	-20.75%
Mar 31, 2025	JANUS HENDERSON GROUP PLC	4.27%	1.42M	74.45M	205.44K	+16.87%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.21%	70.94K	3.52M	42.13K	+146.26%

Insiders

Among the IRON insiders holding of 10.61% of the stake in company, AI DMI LLC, 10 percent owner, holds the largest shares of 2.81M. QUISEL JOHN D, Chief Executive Officer, is the second largest IRON insider with ownership of 226.06K shares. ATLAS VENTURE FUND X, L.P., 10 percent owner, stands third with possession of 198.33K shares of that stake.

Insiders	Designation	Shares Held
AI DMI LLC	10 percent owner	2.81M
QUISEL JOHN D	Chief Executive Officer	226.06K
ATLAS VENTURE FUND X, L.P.	10 percent owner	198.33K
ASHIYA MONA	director	186.54K
ORBIMED ADVISORS LLC	director	186.54K
SAVAGE WILLIAM JACOB	Chief Medical Officer	85.21K
STEPHENSON PAMELA	Chief Commercial Officer	81K
FRANCHI JEAN M.	Chief Financial Officer	70.99K
YU JONATHAN YEN-WEN	Chief Operating Officer	54.32K
KHARA RAHUL	Chief Legal Officer	52.17K
BITTERMAN KEVIN	director	14.01K
WHITE WILLIAM RICHARD	director	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Mar 02, 2026	SAVAGE WILLIAM JACOB	SALE	66.41	2.99K	198.3K	85.21K
Feb 25, 2026	FRANCHI JEAN M.	SALE	69.06	353	24.38K	70.99K
Feb 18, 2026	FRANCHI JEAN M.	SALE	65.89	3.68K	242.73K	71.34K
Feb 17, 2026	SAVAGE WILLIAM JACOB	SALE	62.86	3.26K	204.67K	92.59K
Feb 17, 2026	YU JONATHAN YEN-WEN	SALE	62.86	3.23K	203.1K	54.32K
Feb 17, 2026	STEPHENSON PAMELA	SALE	62.86	5.53K	347.68K	81K
Feb 17, 2026	FRANCHI JEAN M.	SALE	62.86	4.08K	256.15K	78.42K
Feb 17, 2026	KHARA RAHUL	SALE	62.86	2.85K	179.34K	52.17K
Feb 17, 2026	QUISEL JOHN D	SALE	62.86	13.26K	833.78K	226.06K
Jan 20, 2026	KHARA RAHUL	SALE	69.74	1K	69.74K	37.79K
Jan 02, 2026	KHARA RAHUL	SALE	79.27	1.16K	91.72K	37.79K
Dec 17, 2025	BITTERMAN KEVIN	SALE	91.47	148	13.54K	14.01K
Dec 16, 2025	BITTERMAN KEVIN	SALE	91.24	14.36K	1.31M	14.16K
Dec 15, 2025	SAVAGE WILLIAM JACOB	SALE	92.23	300	27.67K	75.7K
Dec 15, 2025	BITTERMAN KEVIN	SALE	91.87	7K	643.09K	0
Dec 12, 2025	BITTERMAN KEVIN	SALE	93.80	1.37K	128.6K	41.52K
Dec 11, 2025	QUISEL JOHN D	SALE	93.65	16.89K	1.58M	171.83K
Nov 11, 2025	YU JONATHAN YEN-WEN	SALE	85.91	8.04K	690.74K	40.56K
Oct 22, 2025	AI DMI LLC	SALE	80.47	744.05K	59.87M	2.81M
Oct 17, 2025	BITTERMAN KEVIN	SALE	91.88	450	41.35K	385.55K
Oct 16, 2025	BITTERMAN KEVIN	SALE	77.11	1.43K	109.88K	477.04K
Oct 15, 2025	BITTERMAN KEVIN	SALE	77.76	2.62K	203.58K	478.46K
Oct 08, 2025	BITTERMAN KEVIN	SALE	72.39	13.27K	960.4K	500.62K
Oct 07, 2025	BITTERMAN KEVIN	SALE	69.01	6.66K	459.68K	572.58K
Aug 22, 2025	BITTERMAN KEVIN	SALE	61.03	2.29K	139.58K	590.62K
Aug 14, 2025	BITTERMAN KEVIN	SALE	60.99	7.21K	439.86K	592.91K
Aug 13, 2025	BITTERMAN KEVIN	SALE	61.15	24.96K	1.53M	600.12K
Aug 05, 2025	BITTERMAN KEVIN	SALE	60.95	395	24.08K	625.08K
Jul 30, 2025	BITTERMAN KEVIN	SALE	61.04	8.49K	518.35K	625.48K
Jul 24, 2025	BITTERMAN KEVIN	SALE	61.17	13.03K	797.23K	633.97K
Jul 23, 2025	BITTERMAN KEVIN	SALE	60.97	29.84K	1.82M	647K
Jul 17, 2025	FRANCHI JEAN M.	SALE	59.00	2.03K	119.83K	63.5K
Jul 10, 2025	FRANCHI JEAN M.	SALE	57.50	2K	115K	65.53K
Jul 09, 2025	QUISEL JOHN D	SALE	56.20	3.59K	201.92K	161.83K
Jul 03, 2025	QUISEL JOHN D	SALE	55.09	5.2K	286.45K	161.83K
Jun 16, 2025	FRANCHI JEAN M.	SALE	52.26	2K	104.52K	67.53K
Jun 06, 2025	SAVAGE WILLIAM JACOB	SALE	50.00	3K	149.8K	56.73K
May 20, 2025	SAVAGE WILLIAM JACOB	SALE	50.04	6.68K	334.13K	59.72K
May 02, 2025	SAVAGE WILLIAM JACOB	SALE	50.17	2.1K	105.37K	66.4K
Mar 24, 2025	ASHIYA MONA	SALE	54.11	756	40.91K	186.54K
Mar 24, 2025	ORBIMED ADVISORS LLC	SALE	54.11	756	40.91K	186.54K
Mar 21, 2025	ORBIMED ADVISORS LLC	SALE	54.00	1.32K	71.28K	187.3K
Mar 21, 2025	ASHIYA MONA	SALE	54.00	1.32K	71.28K	187.3K
Mar 20, 2025	ORBIMED ADVISORS LLC	SALE	54.01	364	19.66K	188.62K
Mar 20, 2025	ASHIYA MONA	SALE	54.01	364	19.66K	188.62K
Mar 19, 2025	ORBIMED ADVISORS LLC	SALE	54.02	5.23K	282.42K	188.98K
Mar 19, 2025	ASHIYA MONA	SALE	54.02	5.23K	282.42K	188.98K
Mar 12, 2025	ASHIYA MONA	SALE	54.44	10.73K	584.3K	194.21K
Mar 12, 2025	ORBIMED ADVISORS LLC	SALE	54.44	10.73K	584.3K	194.21K
Mar 11, 2025	ASHIYA MONA	SALE	54.01	3.57K	192.65K	205.18K
Mar 11, 2025	ORBIMED ADVISORS LLC	SALE	54.01	3.57K	192.65K	205.18K
Mar 10, 2025	ASHIYA MONA	SALE	55.01	53	2.92K	208.74K
Mar 10, 2025	ORBIMED ADVISORS LLC	SALE	55.01	53	2.92K	208.74K
Feb 18, 2025	STEPHENSON PAMELA	SALE	54.58	3.14K	171.22K	69.53K
Feb 18, 2025	SAVAGE WILLIAM JACOB	SALE	54.58	1.64K	89.4K	68.5K
Feb 18, 2025	KHARA RAHUL	SALE	54.58	1.16K	63.37K	37.58K
Feb 18, 2025	YU JONATHAN YEN-WEN	SALE	54.58	1.61K	87.87K	40.56K
Feb 18, 2025	FRANCHI JEAN M.	SALE	54.58	3.14K	171.16K	69.53K
Feb 18, 2025	QUISEL JOHN D	SALE	54.58	5.57K	304.23K	154.83K
Feb 03, 2025	KHARA RAHUL	SALE	56.01	1.81K	101.54K	14.04K
Jan 02, 2025	KHARA RAHUL	SALE	64.13	2.1K	134.68K	14.04K
Dec 30, 2024	QUISEL JOHN D	SALE	62.41	1.9K	118.58K	72.07K
Dec 23, 2024	QUISEL JOHN D	SALE	63.80	4.21K	268.73K	72.07K
Dec 16, 2024	QUISEL JOHN D	SALE	67.20	500	33.6K	72.07K
Dec 02, 2024	WHITE WILLIAM RICHARD	SALE	65.33	173	11.3K	0
Nov 25, 2024	SAVAGE WILLIAM JACOB	SALE	67.02	1.9K	127.61K	40.41K
Nov 15, 2024	SAVAGE WILLIAM JACOB	SALE	61.10	100	6.11K	40.41K
Nov 04, 2024	WHITE WILLIAM RICHARD	SALE	58.94	5.35K	315.12K	0
Nov 01, 2024	WHITE WILLIAM RICHARD	SALE	46.75	129	6.03K	0
Oct 01, 2024	WHITE WILLIAM RICHARD	SALE	52.53	79	4.15K	0
Sep 16, 2024	SAVAGE WILLIAM JACOB	SALE	47.41	1.5K	71.12K	40.41K
Sep 03, 2024	SAVAGE WILLIAM JACOB	SALE	50.59	1.5K	75.89K	41.91K
Sep 03, 2024	WHITE WILLIAM RICHARD	SALE	52.28	10	522.8	0
Aug 01, 2024	WHITE WILLIAM RICHARD	SALE	43.95	57	2.51K	0
Jul 01, 2024	WHITE WILLIAM RICHARD	SALE	46.45	74	3.44K	0
Jun 17, 2024	ASHIYA MONA	PURCHASE	36.00	10.99K	395.5K	235.39K
Jun 17, 2024	ORBIMED ADVISORS LLC	PURCHASE	36.00	10.99K	395.5K	235.39K
Jun 17, 2024	BITTERMAN KEVIN	PURCHASE	36.00	222.22K	8M	420.55K
Jun 03, 2024	WHITE WILLIAM RICHARD	SALE	36.72	95	3.49K	0
May 01, 2024	WHITE WILLIAM RICHARD	SALE	29.11	39	1.14K	0
Apr 11, 2024	WHITE WILLIAM RICHARD	SALE	32.18	78	2.51K	0
Mar 05, 2024	BITTERMAN KEVIN	SALE	73.50	26.16K	1.92M	677.5K
Jan 23, 2024	ATLAS VENTURE FUND X, L.P.	SALE	67.65	20K	1.35M	198.33K
Jan 23, 2024	BITTERMAN KEVIN	SALE	67.65	20K	1.35M	198.33K
Jan 10, 2024	ATLAS VENTURE FUND X, L.P.	SALE	64.00	20K	1.28M	786.16K
Dec 14, 2023	ATLAS VENTURE FUND X, L.P.	SALE	59.74	120	7.17K	806.16K
Dec 13, 2023	ATLAS VENTURE FUND X, L.P.	SALE	60.50	40	2.42K	826.71K
Dec 12, 2023	ATLAS VENTURE FUND X, L.P.	SALE	65.77	6.6K	434.02K	830.26K
Aug 15, 2023	ATLAS VENTURE FUND X, L.P.	SALE	52.40	72.93K	3.82M	882.22K
Aug 14, 2023	ATLAS VENTURE FUND X, L.P.	SALE	54.80	2K	109.6K	2.06M
Jun 16, 2023	AI DMI LLC	PURCHASE	0.00	204.08K	20.41	204.08K
Feb 15, 2023	AI DMI LLC	PURCHASE	23.00	434.78K	10M	3.14M

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES857.96K24

NET SHARES-857.96K24

SHARES HELD6.47M24

% NET SHARES-113.25%0%

Frequently Asked Questions

Stock Outstanding Shares

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares6.5

Short Percent Of Float7.24

Shares Outstanding34.77M

Shares Float28.68M

Shares Short2.26M

Short Ratio6.54

7.24%

Short % of Float

6.5%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

10.61% Percentage of Shares held by All Insiders

101.75% Percentage of Shares held by All Institutions

113.83% Percentage of Float held by Institutions

220

Number of Institutions Holding Shares

Institutional Ownership

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.18%	62.82K	4.99M	56.02K	+823.82%
Dec 31, 2025	ENSIGN PEAK ADVISORS, INC	0.5%	177.05K	14.06M	0	0
Dec 31, 2025	SEVEN GRAND MANAGERS, LLC	0.1%	35K	2.78M	35K	+100.00%
Dec 31, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.1%	36.09K	2.87M	-1.21K	-3.24%
Dec 31, 2025	CITIGROUP INC	0.1%	36.18K	2.87M	32.13K	+794.34%
Dec 31, 2025	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	0.11%	40.2K	3.19M	39.99K	+18,774.65%
Dec 31, 2025		0.12%	42.78K	3.4B	42.78K	+100.00%
Dec 31, 2025	STATE STREET CORP	3.38%	1.19M	94.34M	142.39K	+13.62%
Dec 31, 2025	JPMORGAN CHASE & CO	4.49%	1.58M	125.56M	828.25K	+110.01%
Dec 31, 2025	VANGUARD GROUP INC	5.02%	1.77M	140.37M	319.62K	+22.07%
Dec 31, 2025	BLACKROCK, INC.	6.47%	2.27M	180.66M	255.7K	+12.66%
Dec 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	4.32%	1.52M	120.57M	108.2K	+7.67%
Dec 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	4.83%	1.7M	134.84M	371.58K	+28.01%
Dec 31, 2025	RA CAPITAL MANAGEMENT, L.P.	5.62%	1.98M	156.92M	399.03K	+25.30%
Dec 31, 2025	CATALIO CAPITAL MANAGEMENT, LP	0.31%	110.43K	8.77M	-106.1K	-49.00%
Dec 31, 2025	SOFINNOVA INVESTMENTS, INC.	0.32%	111.01K	8.82M	97.46K	+719.08%
Dec 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.33%	114.35K	9.08M	22.97K	+25.14%
Dec 31, 2025	UBS GROUP AG	0.33%	116.11K	9.22M	-55.51K	-32.34%
Dec 31, 2025	LOGOS GLOBAL MANAGEMENT LP	1.45%	510K	40.5M	60K	+13.33%
Dec 31, 2025	VESTAL POINT CAPITAL, LP	2.09%	735K	58.37M	235K	+47.00%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	2.14%	754.2K	59.89M	225.11K	+42.55%
Dec 31, 2025	WOODLINE PARTNERS LP	2.72%	957.83K	76.06M	90.88K	+10.48%
Dec 31, 2025	SIREN, L.L.C.	2.81%	988.4K	78.49M	75K	+8.21%
Dec 31, 2025	ORBIMED ADVISORS LLC	3.03%	1.07M	84.77M	-347.47K	-24.56%
Dec 31, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	3.58%	1.26M	100.06M	-178.53K	-12.41%
Dec 31, 2025	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	4.3%	1.51M	120.22M	-628.74K	-29.34%
Dec 31, 2025	FMR LLC	15.49%	5.45M	432.8M	515.06K	+10.44%
Dec 31, 2025	MORGAN STANLEY	0.21%	74.83K	5.94M	18.75K	+33.44%
Dec 31, 2025	RAYMOND JAMES FINANCIAL INC	0.23%	80.27K	6.18M	-61.21K	-43.26%
Dec 31, 2025	DNB ASSET MANAGEMENT AS	0.24%	84.26K	6.69M	78.73K	+1,425.81%
Dec 31, 2025	BARCLAYS PLC	0.28%	99.61K	7.91M	-7.59K	-7.08%
Dec 31, 2025	CITADEL ADVISORS LLC	0.29%	100.4K	7.97B	50K	+99.22%
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	0.53%	184.78K	14.67M	23.78K	+14.77%
Dec 31, 2025	TIMESSQUARE CAPITAL MANAGEMENT, LLC	0.53%	187.78K	14.91M	5.61K	+3.08%
Dec 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.64%	223.58K	17.75M	-6.85K	-2.97%
Dec 31, 2025	ABRDN PLC	0.67%	234.36K	18.61M	202.3K	+630.98%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.7%	247.04K	19.62M	20.38K	+8.99%
Dec 31, 2025	ALPS ADVISORS INC	0.09%	31K	2.46M	14.21K	+84.62%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.09%	33.27K	2.64M	6.21K	+22.95%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.35%	122.15K	9.7M	84.54K	+224.79%
Dec 31, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	0.38%	132.8K	10.55M	-155K	-53.86%
Dec 31, 2025	OPALEYE MANAGEMENT INC.	0.57%	200K	15.88M	6.23K	+3.21%
Dec 31, 2025	PALO ALTO INVESTORS LP	0.9%	317.46K	25.21M	93.16K	+41.53%
Dec 31, 2025	BAKER BROS. ADVISORS LP	0.96%	337.05K	26.77M	0	0
Dec 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	1.12%	394.37K	31.32M	390.81K	+10,968.59%
Dec 31, 2025	EVENTIDE ASSET MANAGEMENT, LLC	1.12%	395.39K	31.4M	87.35K	+28.36%
Dec 31, 2025	PERCEPTIVE ADVISORS LLC	1.28%	450.74K	35.79M	450.74K	+100.00%
Dec 31, 2025	CHECKPOINT CAPITAL L.P.	1.29%	452.99K	35.97M	22.99K	+5.35%
Dec 31, 2025	ARMISTICE CAPITAL, LLC	1.42%	499.39K	39.66M	63.39K	+14.54%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	0.39%	135.99K	10.8M	-25.2K	-15.63%
Dec 31, 2025	FIRST TURN MANAGEMENT, LLC	0.44%	153.21K	12.17M	-244.49K	-61.48%
Dec 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.63%	221.76K	17.61M	-116.34K	-34.41%
Dec 31, 2025	NORTHERN TRUST CORP	0.65%	228.07K	18.11M	8.58K	+3.91%
Dec 31, 2025	ASSENAGON ASSET MANAGEMENT S.A.	1.02%	357.84K	28.42M	347.4K	+3,329.85%
Dec 31, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.45%	511.16K	40.59M	-408.24K	-44.40%
Dec 31, 2025	FIRST LIGHT ASSET MANAGEMENT, LLC	1.49%	523.17K	41.54M	291.98K	+126.30%
Dec 31, 2025	BVF INC/IL	1.85%	650K	51.62M	650K	+100.00%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.95%	684.96K	54.4M	56.81K	+9.04%
Dec 31, 2025	LOOMIS SAYLES & CO L P	0.8%	282.41K	22.43M	282.41K	+100.00%
Dec 31, 2025	EXOME ASSET MANAGEMENT LLC	0.13%	46.74K	3.71M	-14.61K	-23.82%
Dec 31, 2025	HEALTHINVEST PARTNERS AB	0.14%	47.97K	3.81M	2.28K	+4.98%
Dec 31, 2025	JENNISON ASSOCIATES LLC	1.51%	532.08K	42.25M	532.08K	+100.00%
Dec 31, 2025	FORESITE CAPITAL MANAGEMENT V, LLC	0.85%	299.07K	23.75M	0	0
Dec 31, 2025	SATURN V CAPITAL MANAGEMENT LLC	0.85%	298.43K	23.7M	-42.47K	-12.46%
Dec 31, 2025	GREAT POINT PARTNERS LLC	0.71%	250K	19.85M	250K	+100.00%
Dec 31, 2025	SWISS NATIONAL BANK	0.14%	48K	3.81M	4.4K	+10.09%
Dec 31, 2025	NICHOLAS INVESTMENT PARTNERS, LP	0.14%	48.08K	3.82M	-39.92K	-45.36%
Dec 31, 2025	NUVEEN, LLC	0.14%	48.47K	3.85M	777	+1.63%
Dec 31, 2025	ALYESKA INVESTMENT GROUP, L.P.	0.14%	50K	3.97M	50K	+100.00%
Dec 31, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.14%	50.1K	3.85M	-17.09K	-25.44%
Dec 31, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.15%	52.51K	4.07M	4.93K	+10.37%
Dec 31, 2025	VICTORY CAPITAL MANAGEMENT INC	0.22%	76.34K	6.06M	-73.53K	-49.06%
Dec 31, 2025	PATIENT SQUARE CAPITAL LP	0.21%	74K	5.88M	0	0
Dec 31, 2025	TD ASSET MANAGEMENT INC	0.2%	69.63K	5.53M	10.39K	+17.53%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.19%	67.71K	5.38M	2.91K	+4.49%
Dec 31, 2025	IA GLOBAL ASSET MANAGEMENT INC.	0.19%	66.43K	5.28M	918	+1.40%
Dec 31, 2025	TUDOR INVESTMENT CORP ET AL	0.19%	66.13K	5.25M	66.13K	+100.00%
Dec 31, 2025	VERITION FUND MANAGEMENT LLC	0.18%	63.54K	5.05M	57.4K	+935.95%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.11%	37.61K	2.49M	32.91K	+699.70%
Sep 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	1.33%	465.26K	30.74M	0	0
Sep 30, 2025	FMR LLC	14.09%	4.94M	326.12M	1.69M	+52.05%
Sep 30, 2025	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	6.12%	2.14M	141.58M	-241.84K	-10.14%
Sep 30, 2025	BLACKROCK, INC.	5.77%	2.02M	133.43M	-25.54K	-1.25%
Sep 30, 2025	VANGUARD GROUP INC	4.13%	1.45M	95.69M	51.32K	+3.67%
Sep 30, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	4.11%	1.44M	95.06M	-216.3K	-13.07%
Sep 30, 2025	ORBIMED ADVISORS LLC	4.04%	1.42M	93.5M	0	0
Sep 30, 2025	FIRST TURN MANAGEMENT, LLC	1.14%	397.69K	26.28M	98.23K	+32.80%
Sep 30, 2025	RA CAPITAL MANAGEMENT, L.P.	4.5%	1.58M	104.22M	0	0
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	4.03%	1.41M	93.18M	-22.01K	-1.54%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	3.79%	1.33M	87.65M	-189.2K	-12.48%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.19%	64.8K	4.28M	-6.7K	-9.37%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.17%	59.25K	3.92M	6.2K	+11.69%
Sep 30, 2025	NUVEEN, LLC	0.14%	47.69K	3.15M	-2.58K	-5.12%
Sep 30, 2025	HEALTHINVEST PARTNERS AB	0.13%	45.69K	320.53K	21.04K	+85.34%
Sep 30, 2025	SWISS NATIONAL BANK	0.12%	43.6K	2.88M	700	+1.63%
Sep 30, 2025	Y-INTERCEPT (HONG KONG) LTD	0.12%	43.29K	2.86M	33.91K	+361.38%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.11%	37.3K	2.46M	5.81K	+18.46%
Sep 30, 2025	RHUMBLINE ADVISERS	0.1%	34.49K	2.28M	-1.27K	-3.54%
Sep 30, 2025	ABRDN PLC	0.09%	32.06K	2.12M	0	0
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.08%	27.94K	1.85M	27.94K	+100.00%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.08%	27.06K	1.79M	4.59K	+20.45%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.07%	25.15K	1.66M	1.05K	+4.36%
Sep 30, 2025	PNC FINANCIAL SERVICES GROUP, INC.	0.07%	25.15K	1.66M	6	+0.02%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.06%	21.49K	1.42M	4.64K	+27.52%
Sep 30, 2025	INVESCO LTD.	0.06%	21.44K	1.42M	4.63K	+27.51%
Sep 30, 2025	DEUTSCHE BANK AG\	0.05%	18.89K	1.25M	2.17K	+12.97%
Sep 30, 2025	BANK OF MONTREAL /CAN/	0.05%	17.79K	1.18M	6.8K	+61.86%
Sep 30, 2025	ALPS ADVISORS INC	0.05%	16.79K	1.11M	-1.83K	-9.85%
Sep 30, 2025	MARSHALL WACE, LLP	0.04%	14K	925.19K	14K	+100.00%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	13.92K	919.97K	-932	-6.27%
Sep 30, 2025	TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY	0.04%	12.85K	849K	0	0
Sep 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.03%	11.44K	755.82K	4.06K	+55.07%
Sep 30, 2025	LEGATO CAPITAL MANAGEMENT LLC	0.03%	11.29K	745.85K	4.06K	+56.16%
Sep 30, 2025	ASSENAGON ASSET MANAGEMENT S.A.	0.03%	10.43K	689.41K	10.43K	+100.00%
Sep 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.03%	9.03K	596.57K	9.03K	+100.00%
Sep 30, 2025	PROFUND ADVISORS LLC	0.02%	8.12K	536.44K	1.4K	+20.91%
Sep 30, 2025	SG AMERICAS SECURITIES, LLC	0.02%	8.06K	533K	8.06K	+100.00%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.02%	8.01K	529.04K	-4.22K	-34.50%
Sep 30, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	7.09K	468.77K	138	+1.98%
Sep 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	2.63%	919.4K	60.75M	0	0
Sep 30, 2025	SIREN, L.L.C.	2.61%	913.4K	60.36M	-186K	-16.92%
Sep 30, 2025	LOGOS GLOBAL MANAGEMENT LP	1.28%	450K	29.74M	-250K	-35.71%
Sep 30, 2025	ARMISTICE CAPITAL, LLC	1.24%	436K	28.81M	0	0
Sep 30, 2025	CHECKPOINT CAPITAL L.P.	1.23%	430K	28.41M	165K	+62.26%
Sep 30, 2025	JANUS HENDERSON GROUP PLC	1.03%	361.7K	23.9M	-1.19M	-76.72%
Sep 30, 2025	SATURN V CAPITAL MANAGEMENT LLC	0.97%	340.9K	22.53M	-55.22K	-13.94%
Sep 30, 2025	FORESITE CAPITAL MANAGEMENT V, LLC	0.85%	299.07K	19.76M	0	0
Sep 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	0.82%	287.8K	19.02M	0	0
Sep 30, 2025	SIO CAPITAL MANAGEMENT, LLC	0.81%	284.79K	18.82M	0	0
Sep 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	0.71%	247.72K	16.37M	-963.26K	-79.54%
Sep 30, 2025	FIRST LIGHT ASSET MANAGEMENT, LLC	0.66%	231.19K	15.28M	231.19K	+100.00%
Sep 30, 2025	CATALIO CAPITAL MANAGEMENT, LP	0.62%	216.53K	14.31M	185.87K	+606.20%
Sep 30, 2025	OPALEYE MANAGEMENT INC.	0.55%	193.77K	12.8M	7.36K	+3.95%
Sep 30, 2025	TIMESSQUARE CAPITAL MANAGEMENT, LLC	0.52%	182.17K	12.04M	182.17K	+100.00%
Sep 30, 2025	ENSIGN PEAK ADVISORS, INC	0.51%	177.05K	11.7M	35.51K	+25.08%
Sep 30, 2025	UBS GROUP AG	0.49%	171.62K	11.34M	26.07K	+17.91%
Sep 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.43%	149.86K	9.9M	-47.96K	-24.24%
Sep 30, 2025	RAYMOND JAMES FINANCIAL INC	0.4%	141.48K	9.35M	54.99K	+63.58%
Sep 30, 2025	BARCLAYS PLC	0.31%	107.2K	7.08M	20.65K	+23.85%
Sep 30, 2025	BLUE OWL CAPITAL HOLDINGS LP	0.29%	102.26K	6.76M	-20K	-16.36%
Sep 30, 2025	WOODLINE PARTNERS LP	2.48%	866.96K	57.29M	0	0
Sep 30, 2025	JPMORGAN CHASE & CO	2.15%	752.88K	49.75M	-90.74K	-10.76%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.79%	628.15K	41.52M	29.56K	+4.94%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.66%	230.42K	15.22M	37.57K	+19.48%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.65%	226.66K	14.98M	22.41K	+10.97%
Sep 30, 2025	PALO ALTO INVESTORS LP	0.64%	224.3K	14.82M	78.61K	+53.96%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.97%	338.1K	22.34M	338.1K	+100.00%
Sep 30, 2025	BAKER BROS. ADVISORS LP	0.96%	337.05K	22.27M	0	0
Sep 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	0.88%	308.04K	20.36M	13	0.00%
Sep 30, 2025	NORTHERN TRUST CORP	0.63%	219.49K	14.5M	394	+0.18%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.46%	161.18K	10.65M	-7.64K	-4.52%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.46%	161K	10.64M	139.41K	+645.61%
Sep 30, 2025	STATE STREET CORP	2.99%	1.05M	69.09M	115.83K	+12.46%
Sep 30, 2025	HUDSON BAY CAPITAL MANAGEMENT LP	0.29%	102.19K	6.75M	102.19K	+100.00%
Sep 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.26%	91.38K	6.04M	-30.2K	-24.84%
Sep 30, 2025	ZIMMER PARTNERS, LP	0.26%	90.16K	5.96M	0	0
Sep 30, 2025	NICHOLAS INVESTMENT PARTNERS, LP	0.25%	88K	5.82M	33.56K	+61.64%
Sep 30, 2025	AMERIPRISE FINANCIAL INC	0.21%	74.35K	4.91B	-47.17K	-38.82%
Sep 30, 2025	PATIENT SQUARE CAPITAL LP	0.21%	74K	4.89M	0	0
Sep 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.19%	67.2K	4.37M	-15.26K	-18.50%
Sep 30, 2025	IA GLOBAL ASSET MANAGEMENT INC.	0.19%	65.51K	4.33M	65.19K	+20,245.34%
Sep 30, 2025	VESTAL POINT CAPITAL, LP	1.43%	500K	33.04M	360K	+257.14%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.28%	450K	29.74M	0	0
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.51%	529.08K	34.96M	303.23K	+134.26%
Jun 30, 2025	JPMORGAN CHASE & CO	2.41%	843.62K	44.68M	84.28K	+11.10%
Jun 30, 2025	ARMISTICE CAPITAL, LLC	1.24%	436K	23.09M	0	0
Jun 30, 2025	CAPTION MANAGEMENT, LLC	1.22%	426.3K	22.58M	407.2K	+2,131.94%
Jun 30, 2025	SATURN V CAPITAL MANAGEMENT LLC	1.13%	396.12K	20.98M	-122.06K	-23.56%
Jun 30, 2025	ENSIGN PEAK ADVISORS, INC	0.4%	141.55K	7.5M	69.03K	+95.20%
Jun 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.35%	121.58K	6.44M	25.03K	+25.92%
Jun 30, 2025	AMERIPRISE FINANCIAL INC	0.35%	121.52K	6.44M	53.62K	+78.96%
Jun 30, 2025	MORGAN STANLEY	0.32%	110.68K	5.86M	-59.53K	-34.98%
Jun 30, 2025	WOODLINE PARTNERS LP	2.48%	866.96K	45.91M	364.73K	+72.62%
Jun 30, 2025	EVENTIDE ASSET MANAGEMENT, LLC	0.88%	308.03K	16.31M	126.21K	+69.42%
Jun 30, 2025	FIRST TURN MANAGEMENT, LLC	0.86%	299.46K	15.86M	299.46K	+100.00%
Jun 30, 2025	CHECKPOINT CAPITAL L.P.	0.76%	265K	14.03M	21.69K	+8.91%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.48%	168.82K	8.94M	115.01K	+213.75%
Jun 30, 2025	PALO ALTO INVESTORS LP	0.42%	145.69K	7.72M	145.69K	+100.00%
Jun 30, 2025	ZIMMER PARTNERS, LP	0.26%	90.16K	4.78M	47.26K	+110.17%
Jun 30, 2025	BARCLAYS PLC	0.25%	86.56K	4.59M	40.85K	+89.37%
Jun 30, 2025	RAYMOND JAMES FINANCIAL INC	0.25%	86.49K	4.58M	3.21K	+3.86%
Jun 30, 2025	OPALEYE MANAGEMENT INC.	0.53%	186.42K	9.87M	101.42K	+119.32%
Jun 30, 2025	BLUE OWL CAPITAL HOLDINGS LP	0.35%	122.26K	6.47M	-18K	-12.83%
Jun 30, 2025	BAKER BROS. ADVISORS LP	0.96%	337.05K	17.85M	260K	+337.44%
Jun 30, 2025	FMR LLC	9.27%	3.25M	171.89M	21.33K	+0.66%
Jun 30, 2025	SIO CAPITAL MANAGEMENT, LLC	0.81%	284.79K	15.08M	211.28K	+287.41%
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.28%	96.42K	5.11M	-94.8K	-49.58%
Jun 30, 2025	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	6.81%	2.38M	126.28M	0	0
Jun 30, 2025	JANUS HENDERSON GROUP PLC	4.44%	1.55M	82.25M	130.7K	+9.18%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	4.33%	1.52M	80.27M	157.37K	+11.59%
Jun 30, 2025	UBS GROUP AG	0.42%	145.55K	7.71M	72.92K	+100.40%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.71%	598.59K	31.71M	26.61K	+4.65%
Jun 30, 2025	LOGOS GLOBAL MANAGEMENT LP	2%	700K	37.07M	305.66K	+77.51%
Jun 30, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	0.82%	287.8K	15.24M	139.41K	+93.95%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.28%	450K	23.83M	150K	+50.00%
Jun 30, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0.04%	15.04K	798.94K	-97	-0.64%
Jun 30, 2025	PRELUDE CAPITAL MANAGEMENT, LLC	0.05%	18.16K	961.54K	-44	-0.24%
Jun 30, 2025	FORESITE CAPITAL MANAGEMENT V, LLC	0.85%	299.07K	15.84M	0	0
Jun 30, 2025	ALPS ADVISORS INC	0.05%	18.63K	986.43K	-6.85K	-26.90%
Jun 30, 2025	TD ASSET MANAGEMENT INC	0.15%	53.05K	2.81M	10.6K	+24.97%
Jun 30, 2025	NICHOLAS INVESTMENT PARTNERS, LP	0.16%	54.45K	2.88M	54.45K	+100.00%
Jun 30, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.17%	57.95K	3.07M	44.38K	+327.17%
Jun 30, 2025	EXOME ASSET MANAGEMENT LLC	0.18%	61.36K	3.25M	-300	-0.49%
Jun 30, 2025	PATIENT SQUARE CAPITAL LP	0.21%	74K	3.92M	-9K	-10.84%
Jun 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.24%	82.45K	4.49M	-4.84K	-5.54%
Jun 30, 2025	VESTAL POINT CAPITAL, LP	0.4%	140K	7.41M	140K	+100.00%
Jun 30, 2025	BLACKROCK, INC.	5.84%	2.04M	108.29M	-49.73K	-2.37%
Jun 30, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	4.72%	1.65M	87.64M	-100K	-5.70%
Jun 30, 2025	VANGUARD GROUP INC	3.99%	1.4M	73.97M	91.69K	+7.03%
Jun 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	3.46%	1.21M	64.13M	0	0
Jun 30, 2025	SIREN, L.L.C.	3.14%	1.1M	58.22M	27.54K	+2.57%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.64%	225.86K	11.96M	95.11K	+72.74%
Jun 30, 2025	NORTHERN TRUST CORP	0.63%	219.1K	11.6M	10.28K	+4.92%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.58%	204.24K	10.82M	9.52K	+4.89%
Jun 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.56%	197.82K	10.48M	4.16K	+2.15%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.55%	192.86K	10.22M	53.46K	+38.35%
Jun 30, 2025	ORBIMED ADVISORS LLC	4.04%	1.42M	74.94M	0	0
Jun 30, 2025	STATE STREET CORP	2.65%	929.77K	49.24M	11.2K	+1.22%
Jun 30, 2025	RA CAPITAL MANAGEMENT, L.P.	4.5%	1.58M	83.52M	0	0
Jun 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	2.63%	919.4K	48.69M	137.07K	+17.52%
Jun 30, 2025	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	1.67%	583.5K	30.9M	-400K	-40.67%
Jun 30, 2025		0.09%	30.66K	1.62M	30.66K	+100.00%
Jun 30, 2025	ABRDN PLC	0.09%	32.06K	1.7M	32.06K	+100.00%
Jun 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.09%	31.49K	1.67M	-2.55K	-7.50%
Jun 30, 2025	PFM HEALTH SCIENCES, LP	0.09%	30.8K	1.63M	30.8K	+100.00%
Jun 30, 2025	BOLLARD GROUP LLC	0.09%	30.64K	1.62M	30.64K	+100.00%
Jun 30, 2025	HEALTHINVEST PARTNERS AB	0.07%	24.65K	1.31M	24.65K	+100.00%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.07%	24.14K	1.28B	3.08K	+14.62%
Jun 30, 2025	ROYAL BANK OF CANADA	0.06%	22.6K	1.2M	21.4K	+1,786.39%
Jun 30, 2025	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0.06%	20.25K	1.07B	98	+0.49%
Jun 30, 2025	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.06%	19.73K	1.04M	19.73K	+100.00%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	4.09%	1.43M	75.84M	-911.41K	-38.89%
Jun 30, 2025	TCG CROSSOVER MANAGEMENT, LLC	1.33%	465.26K	24.64M	0	0
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	4.73%	1.58M	78.29M	1.58M	+100.00%
Mar 31, 2025	ENSIGN PEAK ADVISORS, INC	0.22%	72.51K	3.6M	32.51K	+81.28%
Mar 31, 2025	UBS GROUP AG	0.22%	72.63K	3.61M	48.29K	+198.37%
Mar 31, 2025	SIO CAPITAL MANAGEMENT, LLC	0.22%	73.51K	3.65M	0	0
Mar 31, 2025	BAKER BROS. ADVISORS LP	0.23%	77.05K	3.82M	0	0
Mar 31, 2025	OPALEYE MANAGEMENT INC.	0.26%	85K	4.22M	85K	+100.00%
Mar 31, 2025	NORTHERN TRUST CORP	0.63%	208.81K	10.37M	21.8K	+11.65%
Mar 31, 2025	D. E. SHAW & CO., INC.	0.66%	219.6K	10.9M	138.41K	+170.48%
Mar 31, 2025	SATURN V CAPITAL MANAGEMENT LLC	1.55%	518.18K	25.72M	8.77K	+1.72%
Mar 31, 2025	PERCEPTIVE ADVISORS LLC	0.45%	150K	7.45M	150K	+100.00%
Mar 31, 2025	EVENTIDE ASSET MANAGEMENT, LLC	0.55%	181.82K	9.03M	181.82K	+100.00%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.57%	191.22K	9.49M	104.8K	+121.27%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.33%	108.5K	5.39M	100.62K	+1,277.07%
Mar 31, 2025	ARMISTICE CAPITAL, LLC	1.31%	436K	21.64M	80K	+22.47%
Mar 31, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	5.27%	1.75M	87.11M	0	0
Mar 31, 2025	BLACKROCK, INC.	6.29%	2.09M	103.97M	234.83K	+12.63%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	7.03%	2.34M	116.33M	948.09K	+67.94%
Mar 31, 2025	FMR LLC	9.68%	3.22M	160.06M	1.36M	+72.77%
Mar 31, 2025	TCG CROSSOVER MANAGEMENT, LLC	1.4%	465.26K	23.1M	-21.7K	-4.46%
Mar 31, 2025	WOODLINE PARTNERS LP	1.51%	502.23K	24.93M	105.63K	+26.63%
Mar 31, 2025	PATIENT SQUARE CAPITAL LP	0.25%	83K	4.12M	26.6K	+47.16%
Mar 31, 2025	RAYMOND JAMES FINANCIAL INC	0.25%	83.28K	4.13M	-4.73K	-5.37%
Mar 31, 2025	SIREN, L.L.C.	3.22%	1.07M	53.21M	1.07M	+100.00%
Mar 31, 2025	PARADIGM BIOCAPITAL ADVISORS LP	3.63%	1.21M	60.11M	-286.75K	-19.15%
Mar 31, 2025	SUVRETTA CAPITAL MANAGEMENT, LLC	0.24%	80K	3.97M	80K	+100.00%
Mar 31, 2025	CHECKPOINT CAPITAL L.P.	0.73%	243.31K	12.08M	58.31K	+31.52%
Mar 31, 2025	PICTET ASSET MANAGEMENT HOLDING SA	0.39%	130.39K	6.47M	904	+0.70%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.39%	130.75K	6.49M	-41.06K	-23.90%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.42%	139.39K	6.92M	-327	-0.23%
Mar 31, 2025	SILVERARC CAPITAL MANAGEMENT, LLC	0.71%	236.47K	11.74M	126.09K	+114.23%
Mar 31, 2025	FORESITE CAPITAL MANAGEMENT V, LLC	0.9%	299.07K	14.85M	0	0
Mar 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.9%	300K	14.89M	-50K	-14.29%
Mar 31, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.26%	87.29K	4.57M	-4.2K	-4.59%
Mar 31, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.29%	96.56K	4.79M	3.45K	+3.71%
Mar 31, 2025	BLUE OWL CAPITAL HOLDINGS LP	0.42%	140.26K	6.96M	20K	+16.63%
Mar 31, 2025	NANTAHALA CAPITAL MANAGEMENT, LLC	0.45%	148.39K	7.37M	-1.61K	-1.07%
Mar 31, 2025	MORGAN STANLEY	0.51%	170.21K	8.45M	20.19K	+13.46%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.72%	571.98K	28.4M	99.28K	+21.00%
Mar 31, 2025	JPMORGAN CHASE & CO	2.28%	759.34K	37.69M	698.32K	+1,144.47%
Mar 31, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	2.35%	782.33K	38.84M	181.82K	+30.28%
Mar 31, 2025	STATE STREET CORP	2.76%	918.57K	45.6M	149.83K	+19.49%
Mar 31, 2025	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	2.95%	983.5K	48.82M	0	0
Mar 31, 2025	VANGUARD GROUP INC	3.92%	1.31M	64.78M	236.8K	+22.17%
Mar 31, 2025		0.34%	112.72K	5.6M	112.72K	+100.00%
Mar 31, 2025	VICTORY CAPITAL MANAGEMENT INC	0.58%	193.66K	9.61M	-42.58K	-18.02%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.58%	194.73K	9.67M	29.65K	+17.96%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	4.08%	1.36M	67.43M	-36.38K	-2.61%
Mar 31, 2025	ORBIMED ADVISORS LLC	4.25%	1.42M	70.24M	-370.55K	-20.75%
Mar 31, 2025	JANUS HENDERSON GROUP PLC	4.27%	1.42M	74.45M	205.44K	+16.87%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.21%	70.94K	3.52M	42.13K	+146.26%

Insiders

Insiders	Designation	Shares Held
AI DMI LLC	10 percent owner	2.81M
QUISEL JOHN D	Chief Executive Officer	226.06K
ATLAS VENTURE FUND X, L.P.	10 percent owner	198.33K
ASHIYA MONA	director	186.54K
ORBIMED ADVISORS LLC	director	186.54K
SAVAGE WILLIAM JACOB	Chief Medical Officer	85.21K
STEPHENSON PAMELA	Chief Commercial Officer	81K
FRANCHI JEAN M.	Chief Financial Officer	70.99K
YU JONATHAN YEN-WEN	Chief Operating Officer	54.32K
KHARA RAHUL	Chief Legal Officer	52.17K
BITTERMAN KEVIN	director	14.01K
WHITE WILLIAM RICHARD	director	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Mar 02, 2026	SAVAGE WILLIAM JACOB	SALE	66.41	2.99K	198.3K	85.21K
Feb 25, 2026	FRANCHI JEAN M.	SALE	69.06	353	24.38K	70.99K
Feb 18, 2026	FRANCHI JEAN M.	SALE	65.89	3.68K	242.73K	71.34K
Feb 17, 2026	SAVAGE WILLIAM JACOB	SALE	62.86	3.26K	204.67K	92.59K
Feb 17, 2026	YU JONATHAN YEN-WEN	SALE	62.86	3.23K	203.1K	54.32K
Feb 17, 2026	STEPHENSON PAMELA	SALE	62.86	5.53K	347.68K	81K
Feb 17, 2026	FRANCHI JEAN M.	SALE	62.86	4.08K	256.15K	78.42K
Feb 17, 2026	KHARA RAHUL	SALE	62.86	2.85K	179.34K	52.17K
Feb 17, 2026	QUISEL JOHN D	SALE	62.86	13.26K	833.78K	226.06K
Jan 20, 2026	KHARA RAHUL	SALE	69.74	1K	69.74K	37.79K
Jan 02, 2026	KHARA RAHUL	SALE	79.27	1.16K	91.72K	37.79K
Dec 17, 2025	BITTERMAN KEVIN	SALE	91.47	148	13.54K	14.01K
Dec 16, 2025	BITTERMAN KEVIN	SALE	91.24	14.36K	1.31M	14.16K
Dec 15, 2025	SAVAGE WILLIAM JACOB	SALE	92.23	300	27.67K	75.7K
Dec 15, 2025	BITTERMAN KEVIN	SALE	91.87	7K	643.09K	0
Dec 12, 2025	BITTERMAN KEVIN	SALE	93.80	1.37K	128.6K	41.52K
Dec 11, 2025	QUISEL JOHN D	SALE	93.65	16.89K	1.58M	171.83K
Nov 11, 2025	YU JONATHAN YEN-WEN	SALE	85.91	8.04K	690.74K	40.56K
Oct 22, 2025	AI DMI LLC	SALE	80.47	744.05K	59.87M	2.81M
Oct 17, 2025	BITTERMAN KEVIN	SALE	91.88	450	41.35K	385.55K
Oct 16, 2025	BITTERMAN KEVIN	SALE	77.11	1.43K	109.88K	477.04K
Oct 15, 2025	BITTERMAN KEVIN	SALE	77.76	2.62K	203.58K	478.46K
Oct 08, 2025	BITTERMAN KEVIN	SALE	72.39	13.27K	960.4K	500.62K
Oct 07, 2025	BITTERMAN KEVIN	SALE	69.01	6.66K	459.68K	572.58K
Aug 22, 2025	BITTERMAN KEVIN	SALE	61.03	2.29K	139.58K	590.62K
Aug 14, 2025	BITTERMAN KEVIN	SALE	60.99	7.21K	439.86K	592.91K
Aug 13, 2025	BITTERMAN KEVIN	SALE	61.15	24.96K	1.53M	600.12K
Aug 05, 2025	BITTERMAN KEVIN	SALE	60.95	395	24.08K	625.08K
Jul 30, 2025	BITTERMAN KEVIN	SALE	61.04	8.49K	518.35K	625.48K
Jul 24, 2025	BITTERMAN KEVIN	SALE	61.17	13.03K	797.23K	633.97K
Jul 23, 2025	BITTERMAN KEVIN	SALE	60.97	29.84K	1.82M	647K
Jul 17, 2025	FRANCHI JEAN M.	SALE	59.00	2.03K	119.83K	63.5K
Jul 10, 2025	FRANCHI JEAN M.	SALE	57.50	2K	115K	65.53K
Jul 09, 2025	QUISEL JOHN D	SALE	56.20	3.59K	201.92K	161.83K
Jul 03, 2025	QUISEL JOHN D	SALE	55.09	5.2K	286.45K	161.83K
Jun 16, 2025	FRANCHI JEAN M.	SALE	52.26	2K	104.52K	67.53K
Jun 06, 2025	SAVAGE WILLIAM JACOB	SALE	50.00	3K	149.8K	56.73K
May 20, 2025	SAVAGE WILLIAM JACOB	SALE	50.04	6.68K	334.13K	59.72K
May 02, 2025	SAVAGE WILLIAM JACOB	SALE	50.17	2.1K	105.37K	66.4K
Mar 24, 2025	ASHIYA MONA	SALE	54.11	756	40.91K	186.54K
Mar 24, 2025	ORBIMED ADVISORS LLC	SALE	54.11	756	40.91K	186.54K
Mar 21, 2025	ORBIMED ADVISORS LLC	SALE	54.00	1.32K	71.28K	187.3K
Mar 21, 2025	ASHIYA MONA	SALE	54.00	1.32K	71.28K	187.3K
Mar 20, 2025	ORBIMED ADVISORS LLC	SALE	54.01	364	19.66K	188.62K
Mar 20, 2025	ASHIYA MONA	SALE	54.01	364	19.66K	188.62K
Mar 19, 2025	ORBIMED ADVISORS LLC	SALE	54.02	5.23K	282.42K	188.98K
Mar 19, 2025	ASHIYA MONA	SALE	54.02	5.23K	282.42K	188.98K
Mar 12, 2025	ASHIYA MONA	SALE	54.44	10.73K	584.3K	194.21K
Mar 12, 2025	ORBIMED ADVISORS LLC	SALE	54.44	10.73K	584.3K	194.21K
Mar 11, 2025	ASHIYA MONA	SALE	54.01	3.57K	192.65K	205.18K
Mar 11, 2025	ORBIMED ADVISORS LLC	SALE	54.01	3.57K	192.65K	205.18K
Mar 10, 2025	ASHIYA MONA	SALE	55.01	53	2.92K	208.74K
Mar 10, 2025	ORBIMED ADVISORS LLC	SALE	55.01	53	2.92K	208.74K
Feb 18, 2025	STEPHENSON PAMELA	SALE	54.58	3.14K	171.22K	69.53K
Feb 18, 2025	SAVAGE WILLIAM JACOB	SALE	54.58	1.64K	89.4K	68.5K
Feb 18, 2025	KHARA RAHUL	SALE	54.58	1.16K	63.37K	37.58K
Feb 18, 2025	YU JONATHAN YEN-WEN	SALE	54.58	1.61K	87.87K	40.56K
Feb 18, 2025	FRANCHI JEAN M.	SALE	54.58	3.14K	171.16K	69.53K
Feb 18, 2025	QUISEL JOHN D	SALE	54.58	5.57K	304.23K	154.83K
Feb 03, 2025	KHARA RAHUL	SALE	56.01	1.81K	101.54K	14.04K
Jan 02, 2025	KHARA RAHUL	SALE	64.13	2.1K	134.68K	14.04K
Dec 30, 2024	QUISEL JOHN D	SALE	62.41	1.9K	118.58K	72.07K
Dec 23, 2024	QUISEL JOHN D	SALE	63.80	4.21K	268.73K	72.07K
Dec 16, 2024	QUISEL JOHN D	SALE	67.20	500	33.6K	72.07K
Dec 02, 2024	WHITE WILLIAM RICHARD	SALE	65.33	173	11.3K	0
Nov 25, 2024	SAVAGE WILLIAM JACOB	SALE	67.02	1.9K	127.61K	40.41K
Nov 15, 2024	SAVAGE WILLIAM JACOB	SALE	61.10	100	6.11K	40.41K
Nov 04, 2024	WHITE WILLIAM RICHARD	SALE	58.94	5.35K	315.12K	0
Nov 01, 2024	WHITE WILLIAM RICHARD	SALE	46.75	129	6.03K	0
Oct 01, 2024	WHITE WILLIAM RICHARD	SALE	52.53	79	4.15K	0
Sep 16, 2024	SAVAGE WILLIAM JACOB	SALE	47.41	1.5K	71.12K	40.41K
Sep 03, 2024	SAVAGE WILLIAM JACOB	SALE	50.59	1.5K	75.89K	41.91K
Sep 03, 2024	WHITE WILLIAM RICHARD	SALE	52.28	10	522.8	0
Aug 01, 2024	WHITE WILLIAM RICHARD	SALE	43.95	57	2.51K	0
Jul 01, 2024	WHITE WILLIAM RICHARD	SALE	46.45	74	3.44K	0
Jun 17, 2024	ASHIYA MONA	PURCHASE	36.00	10.99K	395.5K	235.39K
Jun 17, 2024	ORBIMED ADVISORS LLC	PURCHASE	36.00	10.99K	395.5K	235.39K
Jun 17, 2024	BITTERMAN KEVIN	PURCHASE	36.00	222.22K	8M	420.55K
Jun 03, 2024	WHITE WILLIAM RICHARD	SALE	36.72	95	3.49K	0
May 01, 2024	WHITE WILLIAM RICHARD	SALE	29.11	39	1.14K	0
Apr 11, 2024	WHITE WILLIAM RICHARD	SALE	32.18	78	2.51K	0
Mar 05, 2024	BITTERMAN KEVIN	SALE	73.50	26.16K	1.92M	677.5K
Jan 23, 2024	ATLAS VENTURE FUND X, L.P.	SALE	67.65	20K	1.35M	198.33K
Jan 23, 2024	BITTERMAN KEVIN	SALE	67.65	20K	1.35M	198.33K
Jan 10, 2024	ATLAS VENTURE FUND X, L.P.	SALE	64.00	20K	1.28M	786.16K
Dec 14, 2023	ATLAS VENTURE FUND X, L.P.	SALE	59.74	120	7.17K	806.16K
Dec 13, 2023	ATLAS VENTURE FUND X, L.P.	SALE	60.50	40	2.42K	826.71K
Dec 12, 2023	ATLAS VENTURE FUND X, L.P.	SALE	65.77	6.6K	434.02K	830.26K
Aug 15, 2023	ATLAS VENTURE FUND X, L.P.	SALE	52.40	72.93K	3.82M	882.22K
Aug 14, 2023	ATLAS VENTURE FUND X, L.P.	SALE	54.80	2K	109.6K	2.06M
Jun 16, 2023	AI DMI LLC	PURCHASE	0.00	204.08K	20.41	204.08K
Feb 15, 2023	AI DMI LLC	PURCHASE	23.00	434.78K	10M	3.14M

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES857.96K24

NET SHARES-857.96K24

SHARES HELD6.47M24

% NET SHARES-113.25%0%

IRON Stock Ownership Breakdown

Disc Medicine

Stock Outstanding Shares

Market Insider

Institutional Ownership

Insiders

Buying/Selling by Insiders

Insider Transaction Summary (6 Months)

Frequently Asked Questions

Stock Outstanding Shares

Market Insider

Institutional Ownership

Insiders

Buying/Selling by Insiders

Insider Transaction Summary (6 Months)

Frequently Asked Questions