How many institutions own BCYC stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own BCYC shares is 147, representing 88.36% of the company's common stock.

Who are the major shareholders selling Bicycle Therapeutics plc stock?

BANK OF AMERICA CORP /DE/, in the last quarter, reduced its stake in BCYC by -28.79% restricting it's holding to 591.54 thousand shares of worth nearly $4.58M. ALPS ADVISORS INC also lessened -6.34% of the BCYC shares from its portfolio, reducing its holding to 24.12 thousand shares of worth $186.71K. DYNAMIC TECHNOLOGY LAB PRIVATE LTD also shunned BCYC shares holding by -39.15% last quarter which brought its holding to 27.96 thousand shares worth $216.00K.

Investors who are buying BCYC stock?

As per its latest 13F filing, RENAISSANCE TECHNOLOGIES LLC increased its stake in BCYC by 62.91% in the last quarter. The institutional holder raised its holding to 518.7 thousand shares having worth more than $4.01M. HORIZON KINETICS ASSET MANAGEMENT LLC also added 4.38% more shares of BCYC to its portfolio, raising its holding to 14.4 thousand shares of worth $111.43K. AMERIPRISE FINANCIAL INC also increased its BCYC shares holding by 21.68% which brought its holding to 14.97 thousand shares worth $115.88M.

BCYC's major insiders: who are they?

The insider with the most stakes in BCYC is BAKER BROS. ADVISORS LP , at the company. Additionally, BCYC stock is highly held by CHIEF EXECUTIVE OFFICER Lee Kevin and CHIEF TECHNOLOGY OFFICER Skynner Michael among others.

Did an insider recently sell BCYC stock?

Company executives, directors, and other insiders own 1.4% percent of Bicycle Therapeutics plc's stock. Within the last six months, there have been 12 transaction(s) in which BCYC insiders have sold stock, totaling 10.84K shares. Insiders that have sold shares include MILNES ALISTAIR, HANNAY MICHAEL CHARLES FERGUSON, and THOMPSON TRAVIS ALVIN.

Which insider recently purchased BCYC stock?

There have been 0 transaction(s) during the past 6-months in which Bicycle Therapeutics plc insiders have bought stock, totalling 0 shares

How much of BCYC does insiders own?

Around 1.61M Bicycle Therapeutics plc shares are held by insiders, which represents about 1.4% of BCYC stock.

Who is the insider with the largest stake?

BCYC , BAKER BROS. ADVISORS LP holds the largest portfolio of the company's shares. BCYC shares owned by BAKER total nearly 914.08 thousand.

Which institution holds the most shares in BCYC?

RENAISSANCE TECHNOLOGIES LLC is the largest institutional owner in BCYC which holds 518.7 thousand shares worth $4.01M or 0.75% of the total BCYC shares outstanding followed by BANK OF AMERICA CORP /DE/ with ownership of 591.54 thousand shares representing 0.85% of the BCYC ownership. HORIZON KINETICS ASSET MANAGEMENT LLC is the third largest stakeholder with 14.4 thousand shares or 0.02% of the ownership worth more than $111.43K.

Is Bicycle Therapeutics plc stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the BCYC is concerned, it is a stock which is optionable.

Is there a short position on BCYC's shares?

Number of BCYC shares short is null. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding BCYC shares are there?

As of today, null shares of BCYC are outstanding.

Is there many float in BCYC stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, BCYC has null shares in float.

BCYC short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for BCYC is null.

Bicycle Therapeutics (BCYC) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding SharesN/A

Short Percent Of FloatN/A

Shares OutstandingN/A

Shares FloatN/A

Shares ShortN/A

Short RatioN/A

N/A

Short % of Float

N/A

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

1.4% Percentage of Shares held by All Insiders

88.36% Percentage of Shares held by All Institutions

89.61% Percentage of Float held by Institutions

147

Number of Institutions Holding Shares

Institutional Ownership

About 88.36% of BCYC shares are held by financial institutions. RENAISSANCE TECHNOLOGIES LLC is the top corporate investor, holding 518.7K shares valued at $4.01M. A 0.75% stake in Bicycle Therapeutics plc is owned by the company. BANK OF AMERICA CORP /DE/ owns 591.54K shares valued at $4.58M, which translates its holding of 0.85% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.75%	518.7K	4.01M	200.3K	+62.91%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.85%	591.54K	4.58M	-239.1K	-28.79%
Sep 30, 2025	HORIZON KINETICS ASSET MANAGEMENT LLC	0.02%	14.4K	111.43K	604	+4.38%
Sep 30, 2025	AMERIPRISE FINANCIAL INC	0.02%	14.97K	115.88M	2.67K	+21.68%
Sep 30, 2025	STATE OF NEW JERSEY COMMON PENSION FUND D	0.03%	20.11K	155.61K	20.11K	+100.00%
Sep 30, 2025	BLACKROCK, INC.	0.41%	282.42K	2.19M	18.07K	+6.84%
Sep 30, 2025	JUMP FINANCIAL, LLC	0.03%	21.42K	165.8K	4.68K	+27.96%
Sep 30, 2025	WOODSTOCK CORP	0.03%	23.93K	185.2K	0	0
Sep 30, 2025	ALPS ADVISORS INC	0.03%	24.12K	186.71K	-1.63K	-6.34%
Sep 30, 2025	DYNAMIC TECHNOLOGY LAB PRIVATE LTD	0.04%	27.96K	216K	-17.99K	-39.15%
Sep 30, 2025	CITIGROUP INC	0%	2.6K	20.13K	1.69K	+184.88%
Sep 30, 2025	RHUMBLINE ADVISERS	0%	3.28K	25.34K	270	+8.99%
Sep 30, 2025	ASSETMARK, INC	0.01%	3.63K	28.06K	1.55K	+74.87%
Sep 30, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.01%	8.1K	62.73K	-762	-8.59%
Sep 30, 2025	JPMORGAN CHASE & CO	0.01%	8.13K	62.9K	490	+6.42%
Sep 30, 2025	COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS	0.01%	10.12K	78.3K	10.12K	+100.00%
Sep 30, 2025	UBS GROUP AG	0.02%	11.37K	88.03K	-22K	-65.92%
Sep 30, 2025	CROSSMARK GLOBAL HOLDINGS, INC.	0.02%	11.39K	88.16K	1	+0.01%
Sep 30, 2025	TOCQUEVILLE ASSET MANAGEMENT L.P.	0.02%	12.3K	95.2K	-10.6K	-46.29%
Sep 30, 2025	VANGUARD PERSONALIZED INDEXING MANAGEMENT, LLC	0.02%	12.95K	100.26K	12.95K	+100.00%
Sep 30, 2025	PNC FINANCIAL SERVICES GROUP, INC.	0.02%	13.08K	101.24K	0	0
Sep 30, 2025	ERSTE ASSET MANAGEMENT GMBH	0.02%	14K	106.54K	0	0
Sep 30, 2025	CERITY PARTNERS LLC	0.02%	14.35K	111.07K	0	0
Sep 30, 2025	PORTLAND INVESTMENT COUNSEL INC.	0.02%	15K	116.1K	0	0
Sep 30, 2025	LONG FOCUS CAPITAL MANAGEMENT, LLC	2.05%	1.42M	10.98M	101.4K	+7.70%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2%	1.38M	10.72M	-83.6K	-5.69%
Sep 30, 2025	ACADIAN ASSET MANAGEMENT LLC	1.9%	1.31M	10.16M	616.06K	+88.20%
Sep 30, 2025	CANDRIAM S.C.A.	1.69%	1.17M	9.07M	0	0
Sep 30, 2025	PRINCIPAL FINANCIAL GROUP INC	1.66%	1.15M	8.89M	451.14K	+64.70%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	1.52%	1.05M	8.16M	-388.87K	-26.94%
Sep 30, 2025	PINNACLE ASSOCIATES LTD	0.28%	196.62K	1.52M	24.67K	+14.34%
Sep 30, 2025	BARCLAYS PLC	0%	2.27K	17.59K	-1.2K	-34.64%
Sep 30, 2025	GAMMA INVESTING LLC	0%	2.12K	16.38K	628	+42.20%
Sep 30, 2025	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0%	1.79K	13.83K	82	+4.81%
Sep 30, 2025	MAN GROUP PLC	0.06%	40.89K	316.5K	12.22K	+42.60%
Sep 30, 2025	CLEARSTEAD ADVISORS, LLC	0%	1.39K	10.78K	0	0
Sep 30, 2025	GF FUND MANAGEMENT CO. LTD.	0%	995	7.7K	-131	-11.63%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0%	811	6.28K	281	+53.02%
Sep 30, 2025	HIGHMARK WEALTH MANAGEMENT LLC	0%	435	3.37K	0	0
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.06%	39.93K	309.02K	-487	-1.21%
Sep 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.04%	30K	220K	0	0
Sep 30, 2025	SILVERCREST ASSET MANAGEMENT GROUP LLC	0.69%	476.98K	3.69M	211.28K	+79.52%
Sep 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.62%	430.9K	3.34M	-1.34M	-75.69%
Sep 30, 2025	PALO ALTO INVESTORS LP	0.32%	221.07K	1.71M	-27.86K	-11.19%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.29%	197.92K	1.53M	23.01K	+13.15%
Sep 30, 2025	EVERSEPT PARTNERS, LP	0.28%	194.44K	1.5M	-17.03K	-8.05%
Sep 30, 2025	PLATINUM INVESTMENT MANAGEMENT LTD	0.27%	184.6K	1.43M	-100.78K	-35.31%
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.27%	184.54K	1.43M	128.34K	+228.37%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.26%	178.09K	1.38M	-15K	-7.77%
Sep 30, 2025	BIRCHVIEW CAPITAL, LP	0.22%	154K	1.19M	154K	+100.00%
Sep 30, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.2%	140.49K	1.09M	0	0
Sep 30, 2025	RANGELEY CAPITAL, LLC	0.19%	130K	1.01M	55K	+73.33%
Sep 30, 2025	FMR LLC	0%	316	2.45K	0	0
Sep 30, 2025	JONES FINANCIAL COMPANIES LLLP	0%	250	1.85K	0	0
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0%	200	1.55K	0	0
Sep 30, 2025	WINCH ADVISORY SERVICES, LLC	0%	172	1.33K	0	0
Sep 30, 2025	MORGAN STANLEY	1.19%	822.71K	6.37M	-214.45K	-20.68%
Sep 30, 2025	JEFFERIES FINANCIAL GROUP INC.	0.58%	401.93K	3.11M	-59.17K	-12.83%
Sep 30, 2025	CITADEL ADVISORS LLC	0.27%	189.03K	1.46M	49.56K	+35.54%
Sep 30, 2025	TWO SIGMA ADVISERS, LP	0.23%	156.7K	1.21M	86.5K	+123.22%
Sep 30, 2025	HANDELSBANKEN FONDER AB	0.22%	150K	1.16M	-50K	-25.00%
Sep 30, 2025	MOORE CAPITAL MANAGEMENT, LP	0.18%	125K	967.5K	50K	+66.67%
Sep 30, 2025	STATE STREET CORP	0.11%	74.41K	575.9K	8.41K	+12.74%
Sep 30, 2025	QUADRATURE CAPITAL LTD	0.04%	27.89K	215.62K	10.16K	+57.26%
Sep 30, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.09%	64.49K	499.17K	0	0
Sep 30, 2025	SEI INVESTMENTS CO	0.07%	49.06K	379.69K	38.42K	+361.18%
Sep 30, 2025	STATE OF TENNESSEE, TREASURY DEPARTMENT	0.06%	44.84K	347.08K	30.46K	+211.79%
Sep 30, 2025	HARBOR CAPITAL ADVISORS, INC.	0.06%	41.37K	320K	-97.29K	-70.17%
Sep 30, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0.15%	103.41K	800.39K	15.69K	+17.89%
Sep 30, 2025	JANE STREET GROUP, LLC	0.15%	102.46K	793.03K	79.85K	+353.22%
Sep 30, 2025	MONIMUS CAPITAL MANAGEMENT, LP	0.12%	85.22K	659.63K	0	0
Sep 30, 2025	NAN FUNG GROUP HOLDINGS LTD	0.1%	68.94K	533.62K	0	0
Sep 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.04%	26.63K	206.11K	62	+0.23%
Sep 30, 2025	BAKER BROS. ADVISORS LP	15.72%	10.89M	84.25M	0	0
Sep 30, 2025	FCPM III SERVICES B.V.	4.99%	3.45M	26.72M	0	0
Sep 30, 2025	ARMISTICE CAPITAL, LLC	4.3%	2.98M	23.05M	178K	+6.36%
Sep 30, 2025	WESTFIELD CAPITAL MANAGEMENT CO LP	4.26%	2.95M	22.85M	172.05K	+6.19%
Sep 30, 2025	SIREN, L.L.C.	2.91%	2.01M	15.58M	0	0
Jun 30, 2025	WOODLINE PARTNERS LP	0.52%	362.33K	2.52M	-1.43K	-0.39%
Jun 30, 2025	BAKER BROS. ADVISORS LP	15.72%	10.89M	75.65M	0	0
Jun 30, 2025	FCPM III SERVICES B.V.	4.99%	3.45M	23.99M	0	0
Jun 30, 2025	ARMISTICE CAPITAL, LLC	4.04%	2.8M	19.46M	128K	+4.79%
Jun 30, 2025	WESTFIELD CAPITAL MANAGEMENT CO LP	4.02%	2.78M	19.32M	123.19K	+4.64%
Jun 30, 2025	SIREN, L.L.C.	2.91%	2.01M	13.99M	200K	+11.03%
Jun 30, 2025	LONG FOCUS CAPITAL MANAGEMENT, LLC	1.9%	1.32M	9.16M	23.54K	+1.82%
Jun 30, 2025	MORGAN STANLEY	1.5%	1.04M	7.21B	37.32K	+3.73%
Jun 30, 2025	TYBOURNE CAPITAL MANAGEMENT (HK) LTD	1.44%	993.74K	6.91M	417.4K	+72.42%
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.46%	318.4K	2.21M	16.9K	+5.61%
Jun 30, 2025	PLATINUM INVESTMENT MANAGEMENT LTD	0.41%	285.38K	1.98M	-2.22K	-0.77%
Jun 30, 2025	AXA S.A.	0.4%	280.15K	1.95M	-273.53K	-49.40%
Jun 30, 2025	EVERSEPT PARTNERS, LP	0.31%	211.47K	1.47M	211.47K	+100.00%
Jun 30, 2025	HANDELSBANKEN FONDER AB	0.29%	200K	1.39M	-15.9K	-7.36%
Jun 30, 2025	CITADEL ADVISORS LLC	0.2%	139.47K	969.3M	9.4K	+7.22%
Jun 30, 2025	TWO SIGMA ADVISERS, LP	0.1%	70.2K	487.89K	70.2K	+100.00%
Jun 30, 2025	NAN FUNG GROUP HOLDINGS LTD	0.1%	68.94K	479.15K	0	0
Jun 30, 2025	GOLDMAN SACHS GROUP INC	0.08%	52.27K	363.24M	27.07K	+107.47%
Jun 30, 2025	UBS OCONNOR LLC	0.07%	50K	11.25K	50K	+100.00%
Jun 30, 2025	SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)	0.06%	42.73K	296.54K	0	0
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.06%	40.41K	280.86K	19.04K	+89.04%
Jun 30, 2025	PALOMA PARTNERS MANAGEMENT CO	0.06%	39.25K	272.79K	39.25K	+100.00%
Jun 30, 2025	DEEP TRACK CAPITAL, LP	1.74%	1.2M	8.36M	436.23K	+56.87%
Jun 30, 2025	SILVERCREST ASSET MANAGEMENT GROUP LLC	0.38%	265.69K	1.85M	0	0
Jun 30, 2025	SOLEUS CAPITAL MANAGEMENT, L.P.	0.14%	100K	695K	100K	+100.00%
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	2.56%	1.77M	12.32M	-1.92M	-51.99%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.12%	1.47M	10.21M	-68.19K	-4.44%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	2.08%	1.44M	10.03M	990.19K	+218.38%
Jun 30, 2025	CANDRIAM S.C.A.	1.69%	1.17M	8.15M	-32.82K	-2.72%
Jun 30, 2025	PALO ALTO INVESTORS LP	0.36%	248.93K	1.73M	0	0
Jun 30, 2025	JANNEY MONTGOMERY SCOTT LLC	0.14%	100.29K	697K	100.29K	+100.00%
Jun 30, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.09%	64.49K	448.22K	-16.31K	-20.18%
Jun 30, 2025	TWO SIGMA INVESTMENTS, LP	0.08%	56.2K	390.58K	56.2K	+100.00%
Jun 30, 2025	DYNAMIC TECHNOLOGY LAB PRIVATE LTD	0.07%	45.95K	320K	45.95K	+100.00%
Jun 30, 2025	UBS GROUP AG	0.05%	33.38K	231.96K	-39.33K	-54.09%
Jun 30, 2025	RANGELEY CAPITAL, LLC	0.11%	75K	521.25K	75K	+100.00%
Jun 30, 2025	MOORE CAPITAL MANAGEMENT, LP	0.11%	75K	521.25K	25K	+50.00%
Jun 30, 2025	MONIMUS CAPITAL MANAGEMENT, LP	0.12%	85.22K	592.31K	85.22K	+100.00%
Jun 30, 2025	HARBOR CAPITAL ADVISORS, INC.	0.2%	138.66K	964K	-9.47K	-6.39%
Jun 30, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.2%	140.49K	976.42K	2.24K	+1.62%
Jun 30, 2025	PINNACLE ASSOCIATES LTD	0.25%	171.95K	1.2M	-42.33K	-19.75%
Jun 30, 2025	LEGAL & GENERAL GROUP PLC	0.25%	174.91K	1.21M	39.25K	+28.93%
Jun 30, 2025	TD ASSET MANAGEMENT INC	0.28%	193.09K	1.34M	0	0
Jun 30, 2025	BANK OF AMERICA CORP /DE/	1.2%	830.63K	5.77M	267.08K	+47.39%
Jun 30, 2025	BLACKROCK, INC.	0.38%	264.35K	1.84M	-58.53K	-18.13%
Jun 30, 2025	JEFFERIES FINANCIAL GROUP INC.	0.67%	461.1K	3.2M	52.21K	+12.77%
Jun 30, 2025	PRINCIPAL FINANCIAL GROUP INC	1.01%	697.27K	4.85M	66.01K	+10.46%
Jun 30, 2025	ACADIAN ASSET MANAGEMENT LLC	1.01%	698.5K	4.84M	572.44K	+454.09%
Jun 30, 2025	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	1.5%	1.04M	7.24M	-178.23K	-14.61%
Jun 30, 2025	STATE STREET CORP	0.1%	66K	458.68K	-19.66K	-22.95%
Jun 30, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0.13%	87.72K	609.63K	40.47K	+85.65%
Jun 30, 2025		0.11%	75K	521.25K	75K	+100.00%
Jun 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.04%	30K	211K	0	0
Mar 31, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.2%	138.25K	1.17M	13.75K	+11.05%
Mar 31, 2025	LEGAL & GENERAL GROUP PLC	0.2%	135.66K	1.17M	-3.42K	-2.46%
Mar 31, 2025	CITADEL ADVISORS LLC	0.04%	27.7K	235.17K	21.1K	+319.70%
Mar 31, 2025	STATE STREET CORP	0.12%	85.65K	727.19K	-2.11K	-2.41%
Mar 31, 2025	CAPTION MANAGEMENT, LLC	0.12%	81.56K	692.44K	-81.52K	-49.99%
Mar 31, 2025	MOORE CAPITAL MANAGEMENT, LP	0.07%	50K	424.5K	50K	+100.00%
Mar 31, 2025	CUBIST SYSTEMATIC STRATEGIES, LLC	0.07%	47.25K	401.14K	-2.65K	-5.31%
Mar 31, 2025	SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)	0.06%	42.73K	362.98K	0	0
Mar 31, 2025	FCPM III SERVICES B.V.	4.99%	3.45M	29.31M	0	0
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.44%	301.5K	2.56M	32K	+11.87%
Mar 31, 2025	PRINCIPAL FINANCIAL GROUP INC	0.91%	631.26K	5.36M	224.79K	+55.30%
Mar 31, 2025	DEEP TRACK CAPITAL, LP	1.11%	767.02K	6.51M	-509.07K	-39.89%
Mar 31, 2025	SIREN, L.L.C.	2.62%	1.81M	15.39M	-26.65K	-1.45%
Mar 31, 2025	ECOR1 CAPITAL, LLC	1.32%	910K	7.73M	0	0
Mar 31, 2025	UBS OCONNOR LLC	0.21%	148.72K	1.26M	68.49K	+85.36%
Mar 31, 2025	AQUILO CAPITAL MANAGEMENT, LLC	0.25%	171.7K	1.46M	-50.22K	-22.63%
Mar 31, 2025	TD ASSET MANAGEMENT INC	0.28%	193.09K	1.64M	-22.92K	-10.61%
Mar 31, 2025	PINNACLE ASSOCIATES LTD	0.31%	214.28K	1.82M	-12.46K	-5.50%
Mar 31, 2025	LONG FOCUS CAPITAL MANAGEMENT, LLC	1.87%	1.29M	10.98M	750.66K	+138.22%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	2.22%	1.54M	13.05M	-48.54K	-3.06%
Mar 31, 2025	UBS GROUP AG	0.11%	72.7K	617.24K	-59.66K	-45.07%
Mar 31, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.12%	80.8K	685.98K	-40K	-33.11%
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	1.58%	1.09M	9.28M	0	0
Mar 31, 2025	CANDRIAM S.C.A.	1.74%	1.21M	10.23M	117.33K	+10.79%
Mar 31, 2025	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	1.76%	1.22M	10.36M	64.04K	+5.54%
Mar 31, 2025	ENTRYPOINT CAPITAL, LLC	0.04%	28.86K	245K	-15.02K	-34.23%
Mar 31, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.04%	30K	256K	0	0
Mar 31, 2025	PLATINUM INVESTMENT MANAGEMENT LTD	0.42%	287.6K	2.44M	-21.46K	-6.94%
Mar 31, 2025	WOODLINE PARTNERS LP	0.53%	363.75K	3.09M	363.75K	+100.00%
Mar 31, 2025	JEFFERIES FINANCIAL GROUP INC.	0.59%	408.89K	3.47M	408.89K	+100.00%
Mar 31, 2025	PALO ALTO INVESTORS LP	0.36%	248.93K	2.11M	0	0
Mar 31, 2025	AXA S.A.	0.8%	553.68K	4.7M	-277	-0.05%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.81%	563.56K	4.78M	170.7K	+43.45%
Mar 31, 2025	TYBOURNE CAPITAL MANAGEMENT (HK) LTD	0.83%	576.34K	4.89M	-693.19K	-54.60%
Mar 31, 2025	WESTFIELD CAPITAL MANAGEMENT CO LP	3.84%	2.66M	22.56M	46.97K	+1.80%
Mar 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	5.34%	3.69M	31.35M	-862.83K	-18.94%
Mar 31, 2025	BAKER BROS. ADVISORS LP	15.73%	10.89M	92.42M	0	0
Mar 31, 2025	MORGAN STANLEY	1.44%	999.84K	8.49M	137.7K	+15.97%
Mar 31, 2025	WOODSTOCK CORP	0.04%	24.98K	212.09K	0	0
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.04%	25.19K	213.88K	25.19K	+100.00%
Mar 31, 2025	SHAY CAPITAL LLC	0.09%	60K	509.4K	60K	+100.00%
Mar 31, 2025	NAN FUNG GROUP HOLDINGS LTD	0.1%	68.94K	585.33K	0	0
Mar 31, 2025	ACADIAN ASSET MANAGEMENT LLC	0.18%	126.06K	1.07M	126.06K	+100.00%
Mar 31, 2025	HANDELSBANKEN FONDER AB	0.31%	215.9K	1.83M	0	0
Mar 31, 2025	SILVERCREST ASSET MANAGEMENT GROUP LLC	0.38%	265.69K	2.26M	127.95K	+92.89%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.66%	453.43K	3.85M	276.67K	+156.53%
Mar 31, 2025	ARMISTICE CAPITAL, LLC	3.86%	2.67M	22.69M	476K	+21.68%
Mar 31, 2025	BLACKROCK, INC.	0.47%	322.88K	2.74M	-42.53K	-11.64%
Mar 31, 2025	HARBOR CAPITAL ADVISORS, INC.	0.21%	148.13K	1.26M	16.62K	+12.64%
Mar 31, 2024	SOLEUS CAPITAL MANAGEMENT, L.P.	0.36%	153K	3.81M	58K	+61.05%
Mar 31, 2024	FIRST LIGHT ASSET MANAGEMENT, LLC	2.81%	1.19M	29.71M	-357.42K	-23.05%
Mar 31, 2024	WESTFIELD CAPITAL MANAGEMENT CO LP	2.45%	1.04M	25.87M	121.61K	+13.26%
Mar 31, 2024	POLAR CAPITAL HOLDINGS PLC	2.37%	1M	25.01M	0	0
Mar 31, 2024	SUVRETTA CAPITAL MANAGEMENT, LLC	2.16%	914.48K	22.77M	0	0
Mar 31, 2024	CANDRIAM S.C.A.	2.1%	889.26K	22.14M	20K	+2.30%
Mar 31, 2024	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	2.08%	883.11K	21.99M	100.11K	+12.79%
Mar 31, 2024	RA CAPITAL MANAGEMENT, L.P.	1.89%	800K	19.92M	0	0
Mar 31, 2024	BLACKROCK INC.	1.36%	575.03K	14.32M	73.41K	+14.63%
Mar 31, 2024	AXA S.A.	1.31%	554.16K	13.8M	77	+0.01%
Mar 31, 2024	PARKMAN HEALTHCARE PARTNERS LLC	1.24%	524.25K	13.05M	211.36K	+67.55%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	0.94%	396.81K	9.88M	-64.52K	-13.99%
Mar 31, 2024	VOYA INVESTMENT MANAGEMENT LLC	0.32%	136.78K	3.41M	23.63K	+20.88%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0.31%	133.07K	3.31M	263	+0.20%
Mar 31, 2024	DAFNA CAPITAL MANAGEMENT LLC	0.29%	122.2K	3.04M	0	0
Mar 31, 2024	TREXQUANT INVESTMENT LP	0.22%	92.55K	2.3M	-103.77K	-52.86%
Mar 31, 2024	PINNACLE ASSOCIATES LTD	0.19%	80.09K	1.99M	80.09K	+100.00%
Mar 31, 2024	COMERICA BANK	0.19%	78.77K	1.96M	-3.08K	-3.76%
Mar 31, 2024	UBS OCONNOR LLC	0.17%	70K	129.5K	-55K	-44.00%
Mar 31, 2024	ALPHACENTRIC ADVISORS LLC	0.14%	60K	1.49M	60K	+100.00%
Mar 31, 2024	CITADEL ADVISORS LLC	0.14%	59.44K	1.48M	-235.03K	-79.81%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.13%	55.45K	1.38M	55.45K	+100.00%
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.13%	54.99K	1.37M	19.8K	+56.27%
Mar 31, 2024	L & S ADVISORS INC	0.12%	50.26K	1.25M	40.07K	+393.23%
Mar 31, 2024	NATIONAL BANK OF CANADA /FI/	0.11%	48.7K	1.11M	48.7K	+100.00%
Mar 31, 2024	TWO SIGMA ADVISERS, LP	0.11%	46.6K	1.16M	-15.61K	-25.09%
Mar 31, 2024	HARBOR CAPITAL ADVISORS, INC.	0.1%	43.48K	1.08M	16.79K	+62.92%
Mar 31, 2024	SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)	0.1%	42.73K	1.06M	42.73K	+100.00%
Mar 31, 2024	WEXFORD CAPITAL LP	0.08%	34.88K	868.49K	0	0
Mar 31, 2024	ALLIANZ ASSET MANAGEMENT GMBH	0.07%	30.6K	761.94K	0	0
Mar 31, 2024	DEKABANK DEUTSCHE GIROZENTRALE	0.07%	30K	700K	0	0
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.06%	25.96K	646.35K	12.79K	+97.05%
Mar 31, 2024	WOODSTOCK CORP	0.06%	24.98K	622.03K	3.5K	+16.30%
Mar 31, 2024	CONCURRENT INVESTMENT ADVISORS, LLC	0.05%	21.8K	542.8K	21.8K	+100.00%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	0.05%	21.38K	532.29K	2.54K	+13.48%
Mar 31, 2024	TOCQUEVILLE ASSET MANAGEMENT L.P.	0.04%	17.45K	434.51K	-5.9K	-25.27%
Mar 31, 2024	JPMORGAN CHASE & CO	0.04%	15.59K	388.14K	5.48K	+54.25%
Mar 31, 2024	HORIZON KINETICS ASSET MANAGEMENT LLC	0.03%	14.4K	358.46K	0	0
Mar 31, 2024	EXCHANGE TRADED CONCEPTS, LLC	0.03%	12.42K	309.28K	5.69K	+84.64%
Mar 31, 2024	UBS GROUP AG	0.02%	9.98K	248.55K	-1.17K	-10.48%
Mar 31, 2024	SIMPLEX TRADING, LLC	0.02%	9.83K	244K	9.83K	+100.00%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.02%	9.1K	226.59K	9.1K	+100.00%
Mar 31, 2024	FISHMAN JAY A LTD/MI	0.02%	9K	224.1K	-25.5K	-73.91%
Mar 31, 2024	PEAK6 INVESTMENTS LLC	0.02%	9K	224.1K	0	0
Mar 31, 2024	BNP PARIBAS ARBITRAGE, SNC	0.02%	8.83K	219.97K	-28.02K	-76.03%
Mar 31, 2024	PDS PLANNING, INC	0.02%	8.45K	210.41K	8.45K	+100.00%
Mar 31, 2024	PNC FINANCIAL SERVICES GROUP, INC.	0.02%	7.7K	191.73K	140	+1.85%
Mar 31, 2024	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	6.86K	171K	2.86K	+71.43%
Mar 31, 2024	HIGHMARK WEALTH MANAGEMENT LLC	0.01%	4.44K	110.43K	0	0
Mar 31, 2024	NATIXIS	0.01%	2.57K	63.24K	-61	-2.32%
Mar 31, 2024	ADVISOR GROUP HOLDINGS, INC.	0%	1.39K	34.59K	-594	-29.95%
Mar 31, 2024	GAMMA INVESTING LLC	0%	871	21.69K	349	+66.86%
Mar 31, 2024	RHUMBLINE ADVISERS	0%	639	15.91K	229	+55.85%
Mar 31, 2024	US BANCORP \DE\	0%	300	7.47K	300	+100.00%
Mar 31, 2024	CITIGROUP INC	0%	128	3.19K	-15.5K	-99.18%
Mar 31, 2024	MACROVIEW INVESTMENT MANAGEMENT LLC	0%	126	3.14K	0	0
Mar 31, 2024	DAIWA SECURITIES GROUP INC.	0%	103	3K	0	0
Mar 31, 2024	GROUP ONE TRADING, L.P.	0%	91	2.27K	-26.17K	-99.65%
Mar 31, 2024	ZURCHER KANTONALBANK (ZURICH CANTONALBANK)	0%	4	100	-454	-99.13%
Mar 31, 2024	JEFFERIES FINANCIAL GROUP INC.	0%	0	-	-1.95M	-100.00%
Mar 31, 2024	ARMISTICE CAPITAL, LLC	3.94%	1.67M	41.63M	136K	+8.85%
Mar 31, 2024	MORGAN STANLEY	3.58%	1.52M	37.77M	487.49K	+47.36%
Mar 31, 2024	BAKER BROS. ADVISORS LP	11.65%	4.94M	123.08M	3.15M	+176.08%
Mar 31, 2024	DEEP TRACK CAPITAL, LP	8.23%	3.49M	86.91M	0	0
Mar 31, 2024	PARADIGM BIOCAPITAL ADVISORS LP	7.65%	3.25M	80.84M	-460.24K	-12.42%
Mar 31, 2024	TYBOURNE CAPITAL MANAGEMENT (HK) LTD	3.64%	1.55M	38.47M	-105.29K	-6.38%
Mar 31, 2024	CAMBER CAPITAL MANAGEMENT LP	1.06%	450K	11.21M	0	0
Mar 31, 2024	SCHONFELD STRATEGIC ADVISORS LLC	0.99%	420.8K	10.48M	313.8K	+293.27%
Mar 31, 2024	PRICE T ROWE ASSOCIATES INC /MD/	0.95%	401.65K	10M	124.81K	+45.08%
Mar 31, 2024	POINT72 ASSET MANAGEMENT, L.P.	0.81%	342.59K	8.53M	116.7K	+51.66%
Mar 31, 2024	VERITION FUND MANAGEMENT LLC	0.8%	340.87K	8.49M	-399.67K	-53.97%
Mar 31, 2024	PLATINUM INVESTMENT MANAGEMENT LTD	0.79%	333K	8.29M	-29.08K	-8.03%
Mar 31, 2024	KENNEDY CAPITAL MANAGEMENT LLC	0.59%	252.17K	6.28M	-164.31K	-39.45%
Mar 31, 2024	RUBRIC CAPITAL MANAGEMENT LP	0.48%	205.42K	5.12M	0	0
Mar 31, 2024	DUQUESNE FAMILY OFFICE LLC	0.45%	190.2K	4.74M	190.2K	+100.00%
Mar 31, 2024	HANDELSBANKEN FONDER AB	0.42%	179.8K	4.48M	40K	+28.61%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.39%	165.7K	4.13M	60.2K	+57.06%
Mar 31, 2024	HIGHVISTA STRATEGIES LLC	0.37%	158.29K	3.94M	0	0
Dec 31, 2023	PRICE T ROWE ASSOCIATES INC /MD/	0.7%	276.84K	5.01M	-316.22K	-53.32%
Dec 31, 2023	TWO SIGMA ADVISERS, LP	0.16%	62.21K	1.12M	-8.49K	-12.01%
Dec 31, 2023		0.19%	74.83K	1.35M	74.83K	+100.00%
Dec 31, 2023	JUMP FINANCIAL, LLC	0.2%	77.33K	1.4M	40.27K	+108.63%
Dec 31, 2023	COMERICA BANK	0.21%	81.85K	1.48M	81.4K	+18,088.89%
Dec 31, 2023	JANE STREET GROUP, LLC	0.21%	82.95K	1.5M	33.58K	+68.00%
Dec 31, 2023	SOLEUS CAPITAL MANAGEMENT, L.P.	0.24%	95K	1.72M	-296.8K	-75.75%
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	0.26%	103.63K	1.87M	80.7K	+351.93%
Dec 31, 2023	RENAISSANCE TECHNOLOGIES LLC	0.27%	105.5K	1.91M	23.5K	+28.66%
Dec 31, 2023	SCHONFELD STRATEGIC ADVISORS LLC	0.27%	107K	1.93M	54.9K	+105.37%
Dec 31, 2023	VOYA INVESTMENT MANAGEMENT LLC	0.29%	113.15K	2.05M	-205	-0.18%
Dec 31, 2023	CUBIST SYSTEMATIC STRATEGIES, LLC	0.29%	113.9K	2.06M	48.36K	+73.78%
Dec 31, 2023	DAFNA CAPITAL MANAGEMENT LLC	0.31%	122.2K	2.21M	0	0
Dec 31, 2023	UBS OCONNOR LLC	0.19%	73.6K	1.33M	-4.3K	-5.52%
Dec 31, 2023	LEGAL & GENERAL GROUP PLC	0.34%	132.81K	2.4M	40.34K	+43.63%
Dec 31, 2023	HANDELSBANKEN FONDER AB	0.35%	139.8K	2.53M	5.3K	+3.94%
Dec 31, 2023	WALLEYE CAPITAL LLC	0.38%	150.13K	2.71M	150.13K	+100.00%
Dec 31, 2023	HIGHVISTA STRATEGIES LLC	0.4%	158.29K	2.86M	65.86K	+71.25%
Dec 31, 2023	MAN GROUP PLC	0.44%	174.07K	3.15M	174.07K	+100.00%
Dec 31, 2023	TREXQUANT INVESTMENT LP	0.5%	196.32K	3.55M	125.6K	+177.61%
Dec 31, 2023	RUBRIC CAPITAL MANAGEMENT LP	0.52%	205.42K	3.71M	0	0
Dec 31, 2023	POINT72 ASSET MANAGEMENT, L.P.	0.57%	225.9K	4.08M	-1.07M	-82.62%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	0.63%	249.14K	4.5M	-65.96K	-20.93%
Dec 31, 2023	FMR LLC	0.67%	266.35K	4.82M	0	0
Dec 31, 2023	CITADEL ADVISORS LLC	0.74%	294.47K	5.32M	158.77K	+117.00%
Dec 31, 2023	PARKMAN HEALTHCARE PARTNERS LLC	0.79%	312.89K	5.66M	190.17K	+154.96%
Dec 31, 2023	PLATINUM INVESTMENT MANAGEMENT LTD	0.91%	362.08K	6.55M	76.6K	+26.83%
Dec 31, 2023	NOMURA HOLDINGS INC	1.01%	400K	7.23M	0	0
Dec 31, 2023	KENNEDY CAPITAL MANAGEMENT LLC	1.05%	416.49K	7.53M	259.78K	+165.78%
Dec 31, 2023	CAMBER CAPITAL MANAGEMENT LP	1.14%	450K	8.14M	50K	+12.50%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	1.17%	461.33K	8.34M	455.04K	+7,227.37%
Dec 31, 2023	BLACKROCK INC.	1.27%	501.62K	9.07M	307.54K	+158.46%
Dec 31, 2023	AXA S.A.	1.4%	554.09K	10.02M	-20.98K	-3.65%
Dec 31, 2023	VERITION FUND MANAGEMENT LLC	1.87%	740.54K	13.39M	-175.84K	-19.19%
Dec 31, 2023	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	1.98%	783K	14.16M	142.12K	+22.18%
Dec 31, 2023	RA CAPITAL MANAGEMENT, L.P.	2.02%	800K	14.46M	0	0
Dec 31, 2023	RIDGEBACK CAPITAL INVESTMENTS L.P.	2.13%	844.24K	15.26M	844.24K	+100.00%
Dec 31, 2023	CANDRIAM S.C.A.	2.2%	869.26K	15.72M	-384K	-30.64%
Dec 31, 2023	SUVRETTA CAPITAL MANAGEMENT, LLC	2.31%	914.48K	16.53M	-96.5K	-9.55%
Dec 31, 2023	WESTFIELD CAPITAL MANAGEMENT CO LP	2.32%	917.3K	16.58M	917.3K	+100.00%
Dec 31, 2023	POLAR CAPITAL HOLDINGS PLC	2.54%	1M	18.16M	-6.97K	-0.69%
Dec 31, 2023	MORGAN STANLEY	2.6%	1.03M	18.61M	-592.52K	-36.54%
Dec 31, 2023	ARMISTICE CAPITAL, LLC	3.88%	1.54M	27.77M	536K	+53.60%
Dec 31, 2023	FIRST LIGHT ASSET MANAGEMENT, LLC	3.92%	1.55M	28.03M	-520.38K	-25.13%
Dec 31, 2023	TYBOURNE CAPITAL MANAGEMENT (HK) LTD	4.17%	1.65M	29.84M	368.5K	+28.75%
Dec 31, 2023	BAKER BROS. ADVISORS LP	4.52%	1.79M	32.37M	946.58K	+112.18%
Dec 31, 2023	JEFFERIES FINANCIAL GROUP INC.	4.92%	1.95M	35.22M	0	0
Dec 31, 2023	DEEP TRACK CAPITAL, LP	8.82%	3.49M	63.11M	0	0
Dec 31, 2023	PARADIGM BIOCAPITAL ADVISORS LP	9.37%	3.71M	67.02M	64.69K	+1.78%
Sep 30, 2023	JEFFERIES FINANCIAL GROUP INC.	6.45%	1.95M	-	0	0
Sep 30, 2023	HORIZON KINETICS ASSET MANAGEMENT LLC	0.05%	15K	-	0	0
Sep 30, 2023	ALLIANZ ASSET MANAGEMENT GMBH	0.06%	17K	-	-3.4K	-16.67%
Sep 30, 2023	GEODE CAPITAL MANAGEMENT, LLC	0.06%	17.14K	-	0	0
Sep 30, 2023	WOODSTOCK CORP	0.07%	20.55K	-	0	0
Sep 30, 2023	MAVEN SECURITIES LTD	0.07%	22.5K	-	22.5K	+100.00%
Sep 30, 2023	TWO SIGMA INVESTMENTS, LP	0.08%	22.93K	-	-29.7K	-56.43%
Sep 30, 2023	HARBOR CAPITAL ADVISORS, INC.	0.08%	24.21K	-	3.17K	+15.04%
Sep 30, 2023	MACH-1 FINANCIAL GROUP, LLC	0.08%	24.7K	-	24.7K	+100.00%
Sep 30, 2023	AE WEALTH MANAGEMENT LLC	0.08%	24.77K	-	24.77K	+100.00%
Sep 30, 2023	ALPHA DNA INVESTMENT MANAGEMENT LLC	0.09%	27.96K	-	27.96K	+100.00%
Sep 30, 2023	DEKABANK DEUTSCHE GIROZENTRALE	0.1%	30K	-	0	0
Sep 30, 2023	SIMPLEX TRADING, LLC	0.1%	31.53K	-	-34.91K	-52.54%
Sep 30, 2023	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.12%	36.09K	-	10.96K	+43.59%
Sep 30, 2023	JUMP FINANCIAL, LLC	0.12%	37.07K	-	18.91K	+104.10%
Sep 30, 2023	FISHMAN JAY A LTD/MI	0.12%	37.5K	-	17K	+82.93%
Sep 30, 2023	BELLEVUE GROUP AG	0.13%	39.2K	-	14.2K	+56.80%
Sep 30, 2023	JANE STREET GROUP, LLC	0.16%	49.37K	-	49.37K	+100.00%
Sep 30, 2023	GHISALLO CAPITAL MANAGEMENT LLC	0.17%	50K	-	50K	+100.00%
Sep 30, 2023	SCHONFELD STRATEGIC ADVISORS LLC	0.17%	52.1K	-	-14K	-21.18%
Sep 30, 2023	ALPHACENTRIC ADVISORS LLC	0.19%	58.5K	-	58.5K	+100.00%
Sep 30, 2023	CUBIST SYSTEMATIC STRATEGIES, LLC	0.22%	65.55K	-	40.85K	+165.40%
Sep 30, 2023	TWO SIGMA ADVISERS, LP	0.23%	70.7K	-	-68.7K	-49.28%
Sep 30, 2023	TREXQUANT INVESTMENT LP	0.23%	70.72K	-	70.72K	+100.00%
Sep 30, 2023	GROUP ONE TRADING, L.P.	0.27%	81.23K	-	-2.74K	-3.26%
Sep 30, 2023	PARADIGM BIOCAPITAL ADVISORS LP	12.06%	3.64M	-	1.66M	+83.45%
Sep 30, 2023	TD ASSET MANAGEMENT INC	0.27%	81.79K	-	58.2K	+246.76%
Sep 30, 2023	HIGHVISTA STRATEGIES LLC	0.31%	92.43K	-	0	0
Sep 30, 2023	DEUTSCHE BANK AG\	0.32%	96.37K	-	88K	+1,051.37%
Sep 30, 2023	VOYA INVESTMENT MANAGEMENT LLC	0.38%	113.36K	-	24.99K	+28.27%
Sep 30, 2023	DAFNA CAPITAL MANAGEMENT LLC	0.4%	122.2K	-	0	0
Sep 30, 2023	HANDELSBANKEN FONDER AB	0.45%	134.5K	-	0	0
Sep 30, 2023	KENNEDY CAPITAL MANAGEMENT LLC	0.52%	156.71K	-	33.52K	+27.21%
Sep 30, 2023	BLACKROCK INC.	0.64%	194.08K	-	12.98K	+7.16%
Sep 30, 2023	RUBRIC CAPITAL MANAGEMENT LP	0.68%	205.42K	-	0	0
Sep 30, 2023	FMR LLC	0.88%	266.35K	-	-20.8K	-7.24%
Sep 30, 2023	PLATINUM INVESTMENT MANAGEMENT LTD	0.95%	285.48K	-	285.48K	+100.00%
Sep 30, 2023	SOLEUS CAPITAL MANAGEMENT, L.P.	1.3%	391.8K	-	-20K	-4.86%
Sep 30, 2023	NOMURA HOLDINGS INC	1.32%	400K	-	0	0
Sep 30, 2023	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	1.49%	448.75K	-	448.75K	+100.00%
Sep 30, 2023	BNP PARIBAS ASSET MANAGEMENT HOLDING S.A.	2.12%	640.88K	-	131.57K	+25.83%
Sep 30, 2023	SIO CAPITAL MANAGEMENT, LLC	2.64%	796.93K	-	-171.74K	-17.73%
Sep 30, 2023	RA CAPITAL MANAGEMENT, L.P.	2.65%	800K	-	800K	+100.00%
Sep 30, 2023	BAKER BROS. ADVISORS LP	2.79%	843.81K	-	0	0
Sep 30, 2023	ARMISTICE CAPITAL, LLC	3.31%	1M	-	124K	+14.16%
Sep 30, 2023	POLAR CAPITAL HOLDINGS PLC	3.35%	1.01M	-	252K	+33.18%
Sep 30, 2023	CANDRIAM S.C.A.	4.15%	1.25M	-	-20K	-1.57%
Sep 30, 2023	TYBOURNE CAPITAL MANAGEMENT (HK) LTD	4.25%	1.28M	-	0	0
Sep 30, 2023	POINT72 ASSET MANAGEMENT, L.P.	4.3%	1.3M	-	821.5K	+171.86%
Sep 30, 2023	MORGAN STANLEY	5.37%	1.62M	-	182.18K	+12.66%

Insiders

Among the BCYC insiders holding of 1.4% of the stake in company, BAKER BROS. ADVISORS LP, , holds the largest shares of 914.08K. LEE KEVIN, CHIEF EXECUTIVE OFFICER, is the second largest BCYC insider with ownership of 475.31K shares. SKYNNER MICHAEL, CHIEF TECHNOLOGY OFFICER, stands third with possession of 118.28K shares of that stake.

Insiders	Designation	Shares Held
BAKER BROS. ADVISORS LP		914.08K
LEE KEVIN	CHIEF EXECUTIVE OFFICER	475.31K
SKYNNER MICHAEL	CHIEF TECHNOLOGY OFFICER	118.28K
MILNES ALISTAIR	CHIEF OPERATING OFFICER	93.38K
ARROYO SANTIAGO	CHIEF DEVELOPMENT OFFICER	69.06K
KEEN NICHOLAS	CHIEF SCIENTIFIC OFFICER	62.02K
HANNAY MICHAEL CHARLES FERGUSON	CHIEF PROD & SUPPLY CHAIN OFF	53.1K
CROCKETT NIGEL	CHIEF BUSINESS OFFICER	51.05K
YOUNG ALETHIA	Chief Financial Officer	44.7K
BINGHAM KATE	director	38.71K
SMETHURST DOMINIC	Chief Medical Officer	36.7K
THOMPSON TRAVIS ALVIN	CHIEF ACCOUNTING OFFICER	31.2K
KALOWSKI LEE	President and CFO	30.31K
SWANTON ROBERT CHARLES	director	15.49K
LEGAULT PIERRE	director	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Oct 03, 2025	MILNES ALISTAIR	SALE	8.41	978	8.22K	93.38K
Oct 03, 2025	HANNAY MICHAEL CHARLES FERGUSON	SALE	8.41	250	2.1K	53.1K
Oct 03, 2025	THOMPSON TRAVIS ALVIN	SALE	8.41	103	866.23	31.2K
Oct 03, 2025	LEE KEVIN	SALE	8.41	3.23K	27.17K	475.31K
Oct 03, 2025	SKYNNER MICHAEL	SALE	8.41	978	8.22K	118.28K
Oct 02, 2025	THOMPSON TRAVIS ALVIN	SALE	8.40	221	1.86K	31.3K
Oct 02, 2025	HANNAY MICHAEL CHARLES FERGUSON	SALE	8.40	473	3.97K	53.35K
Oct 02, 2025	MILNES ALISTAIR	SALE	8.40	1.15K	9.63K	94.36K
Oct 02, 2025	SKYNNER MICHAEL	SALE	8.40	824	6.92K	119.26K
Oct 02, 2025	LEE KEVIN	SALE	8.40	2.26K	19.01K	478.54K
Oct 02, 2025	SWANTON ROBERT CHARLES	SALE	8.55	102	872.1	15.49K
Oct 02, 2025	YOUNG ALETHIA	SALE	8.61	265	2.28K	44.7K
Jul 03, 2025	THOMPSON TRAVIS ALVIN	SALE	7.44	100	744	31.52K
Jul 03, 2025	HANNAY MICHAEL CHARLES FERGUSON	SALE	7.44	248	1.85K	53.83K
Jul 03, 2025	MILNES ALISTAIR	SALE	7.44	966	7.19K	95.5K
Jul 03, 2025	LEE KEVIN	SALE	7.44	3.19K	23.76K	480.8K
Jul 03, 2025	SKYNNER MICHAEL	SALE	7.44	966	7.19K	120.08K
Jul 02, 2025	SKYNNER MICHAEL	SALE	7.09	825	5.85K	121.05K
Jul 02, 2025	YOUNG ALETHIA	SALE	7.09	204	1.45K	45.19K
Jul 02, 2025	THOMPSON TRAVIS ALVIN	SALE	7.09	206	1.46K	31.62K
Jul 02, 2025	HANNAY MICHAEL CHARLES FERGUSON	SALE	7.09	474	3.36K	54.07K
Jul 02, 2025	MILNES ALISTAIR	SALE	7.09	1.15K	8.15K	96.47K
Jul 02, 2025	LEE KEVIN	SALE	7.09	2.27K	16.08K	484K
Jan 06, 2025	THOMPSON TRAVIS ALVIN	SALE	15.00	2.69K	40.29K	32.15K
Jan 03, 2025	LEE KEVIN	SALE	14.75	3.09K	45.61K	491.93K
Jan 03, 2025	MILNES ALISTAIR	SALE	14.75	936	13.81K	99.79K
Jan 03, 2025	THOMPSON TRAVIS ALVIN	SALE	14.75	159	2.35K	34.83K
Jan 03, 2025	SKYNNER MICHAEL	SALE	14.75	936	13.81K	123.72K
Jan 03, 2025	CROCKETT NIGEL	SALE	14.75	936	13.81K	51.05K
Jan 03, 2025	HANNAY MICHAEL CHARLES FERGUSON	SALE	14.75	239	3.53K	55.28K
Jan 02, 2025	ARROYO SANTIAGO	SALE	14.09	4.94K	69.65K	69.06K
Jan 02, 2025	LEE KEVIN	SALE	14.09	9.04K	127.35K	495.03K
Jan 02, 2025	HANNAY MICHAEL CHARLES FERGUSON	SALE	14.09	1.88K	26.48K	55.52K
Jan 02, 2025	SKYNNER MICHAEL	SALE	14.09	3.29K	46.31K	124.66K
Jan 02, 2025	MILNES ALISTAIR	SALE	14.09	4.58K	64.5K	100.72K
Jan 02, 2025	CROCKETT NIGEL	SALE	14.09	2.58K	36.39K	51.99K
Jan 02, 2025	YOUNG ALETHIA	SALE	14.09	1.4K	19.66K	45.61K
Jan 02, 2025	THOMPSON TRAVIS ALVIN	SALE	14.09	1.75K	24.66K	34.99K
Dec 16, 2024	BAKER BROS. ADVISORS LP	PURCHASE	15.34	42.37K	650.02K	914.08K
Dec 13, 2024	BAKER BROS. ADVISORS LP	PURCHASE	13.50	2.81K	37.92K	790.76K
Nov 11, 2024	THOMPSON TRAVIS ALVIN	SALE	24.82	231	5.73K	19.24K
Oct 03, 2024	CROCKETT NIGEL	SALE	22.26	972	21.64K	45.82K
Oct 03, 2024	SKYNNER MICHAEL	SALE	22.26	972	21.64K	92.95K
Oct 03, 2024	MILNES ALISTAIR	SALE	22.26	972	21.64K	70.3K
Oct 03, 2024	HANNAY MICHAEL CHARLES FERGUSON	SALE	22.26	247	5.5K	22.4K
Oct 03, 2024	THOMPSON TRAVIS ALVIN	SALE	22.26	153	3.41K	22.92K
Oct 03, 2024	LEE KEVIN	SALE	22.26	3.21K	71.5K	380.86K
Jul 03, 2024	MILNES ALISTAIR	SALE	19.64	967	18.99K	71.27K
Jul 03, 2024	KEEN NICHOLAS	SALE	19.64	779	15.3K	62.02K
Jul 03, 2024	LEE KEVIN	SALE	19.64	3.19K	62.73K	384.08K
Jul 03, 2024	HANNAY MICHAEL CHARLES FERGUSON	SALE	19.64	246	4.83K	22.65K
Jul 03, 2024	CROCKETT NIGEL	SALE	19.64	967	18.99K	46.79K
Jul 03, 2024	SKYNNER MICHAEL	SALE	19.64	967	18.99K	93.92K
Jul 03, 2024	THOMPSON TRAVIS ALVIN	SALE	19.64	148	2.91K	23.08K
Apr 11, 2024	HANNAY MICHAEL CHARLES FERGUSON	SALE	22.49	257	5.78K	22.89K
Apr 03, 2024	CROCKETT NIGEL	SALE	23.81	955	22.74K	47.76K
Apr 03, 2024	THOMPSON TRAVIS ALVIN	SALE	23.81	152	3.62K	23.22K
Apr 03, 2024	KEEN NICHOLAS	SALE	23.81	790	18.81K	62.8K
Apr 03, 2024	MILNES ALISTAIR	SALE	23.81	955	22.74K	72.24K
Apr 03, 2024	SKYNNER MICHAEL	SALE	23.81	955	22.74K	94.88K
Apr 03, 2024	LEE KEVIN	SALE	23.81	3.16K	75.19K	387.27K
Jan 03, 2024	KEEN NICHOLAS	SALE	17.50	2.64K	46.2K	63.59K
Jan 03, 2024	CROCKETT NIGEL	SALE	17.50	2.64K	46.25K	48.72K
Jan 03, 2024	THOMPSON TRAVIS ALVIN	SALE	17.50	604	10.57K	23.38K
Jan 03, 2024	LEE KEVIN	SALE	17.50	8.7K	152.3K	390.43K
Jan 03, 2024	MILNES ALISTAIR	SALE	17.50	2.64K	46.25K	73.2K
Jan 03, 2024	SKYNNER MICHAEL	SALE	17.50	2.64K	46.25K	95.84K
Oct 03, 2023	SKYNNER MICHAEL	SALE	20.00	442	8.84K	70.48K
Oct 03, 2023	MILNES ALISTAIR	SALE	20.00	442	8.84K	36.84K
Oct 03, 2023	CROCKETT NIGEL	SALE	20.00	442	8.84K	29.36K
Oct 03, 2023	KEEN NICHOLAS	SALE	20.00	272	5.44K	38.23K
Oct 03, 2023	THOMPSON TRAVIS ALVIN	SALE	20.00	54	1.08K	7.98K
Oct 03, 2023	LEE KEVIN	SALE	20.00	1.47K	29.4K	322.13K
Jul 03, 2023	THOMPSON TRAVIS ALVIN	SALE	25.10	61	1.53K	8.03K
Jul 03, 2023	KEEN NICHOLAS	SALE	25.10	336	8.43K	38.51K
Jul 03, 2023	LEE KEVIN	SALE	25.10	1.5K	37.6K	323.6K
Jul 03, 2023	MILNES ALISTAIR	SALE	25.10	451	11.32K	37.28K
Jul 03, 2023	CROCKETT NIGEL	SALE	25.10	451	11.32K	29.8K
Jul 03, 2023	SKYNNER MICHAEL	SALE	25.10	451	11.32K	70.92K
Apr 03, 2023	LEE KEVIN	SALE	21.11	1.49K	31.37K	325.1K
Apr 03, 2023	CROCKETT NIGEL	SALE	21.11	447	9.44K	30.25K
Apr 03, 2023	KALOWSKI LEE	SALE	21.11	376	7.94K	30.31K
Apr 03, 2023	KEEN NICHOLAS	SALE	21.11	319	6.73K	38.84K
Apr 03, 2023	SKYNNER MICHAEL	SALE	21.11	447	9.44K	71.38K
Apr 03, 2023	MILNES ALISTAIR	SALE	21.11	447	9.44K	37.73K
Jan 03, 2023	KALOWSKI LEE	SALE	29.06	1.82K	52.74K	30.69K
Jan 03, 2023	CROCKETT NIGEL	SALE	29.06	1.8K	52.34K	30.7K
Jan 03, 2023	SKYNNER MICHAEL	SALE	29.06	1.8K	52.34K	71.82K
Jan 03, 2023	SMETHURST DOMINIC	SALE	29.06	1.8K	52.34K	36.7K
Jan 03, 2023	MILNES ALISTAIR	SALE	29.06	1.8K	52.34K	38.18K
Jan 03, 2023	KEEN NICHOLAS	SALE	29.06	1.82K	52.8K	39.16K
Jan 03, 2023	LEE KEVIN	SALE	29.06	6K	174.36K	326.59K
Dec 22, 2021	LEGAULT PIERRE	SALE	58.01	97.86K	5.68M	0
Dec 21, 2021	LEGAULT PIERRE	SALE	57.11	44.54K	2.54M	0
Dec 20, 2021	LEGAULT PIERRE	SALE	57.02	7.6K	433.52K	0
Oct 18, 2021	LEE KEVIN	SALE	60.00	49	2.94K	225.09K
Oct 15, 2021	LEE KEVIN	SALE	60.05	320	19.22K	225.13K
Oct 14, 2021	LEE KEVIN	SALE	60.00	4.63K	277.86K	225.45K
Oct 11, 2021	LEE KEVIN	SALE	54.67	598	32.69K	230.09K
Oct 05, 2021	KEEN NICHOLAS	SALE	45.10	2.18K	98.23K	0
Oct 01, 2021	KEEN NICHOLAS	SALE	45.00	1.19K	53.46K	2.18K
Sep 16, 2021	KEEN NICHOLAS	SALE	45.01	1.96K	87.99K	3.37K
Sep 15, 2021	KEEN NICHOLAS	SALE	45.00	3K	135K	5.32K
Sep 02, 2021	KEEN NICHOLAS	SALE	40.00	10K	400K	8.32K
Sep 02, 2021	KALOWSKI LEE	SALE	40.00	10K	400K	0
Sep 02, 2021	LEE KEVIN	SALE	40.00	5K	200K	235.09K
Sep 01, 2021	LEE KEVIN	SALE	38.08	1.8K	68.39K	240.09K
Aug 31, 2021	LEE KEVIN	SALE	37.08	1.27K	47.17K	244.28K
Aug 27, 2021	LEE KEVIN	SALE	36.02	1.81K	65.12K	245.09K
Aug 27, 2021	KALOWSKI LEE	SALE	35.15	7.95K	279.44K	0
Aug 26, 2021	KALOWSKI LEE	SALE	35.04	550	19.27K	0
Aug 23, 2021	KALOWSKI LEE	SALE	33.02	7.5K	247.65K	0
Jul 29, 2021	KALOWSKI LEE	SALE	32.81	300	9.84K	0
Jul 26, 2021	LEE KEVIN	SALE	36.00	100	3.6K	245.09K
Jul 23, 2021	LEE KEVIN	SALE	36.02	4.78K	172.25K	245.09K
Jul 16, 2021	LEE KEVIN	SALE	34.00	609	20.71K	245.09K
Jul 15, 2021	LEE KEVIN	SALE	34.28	21.97K	753.13K	245.09K
Jul 14, 2021	LEE KEVIN	SALE	35.16	53	1.86K	245.09K
Jul 14, 2021	BINGHAM KATE	SALE	34.01	917	31.18K	38.71K
Jul 14, 2021	KEEN NICHOLAS	SALE	35.00	10K	350K	18.32K
Jul 13, 2021	CROCKETT NIGEL	SALE	33.09	3.12K	103.27K	0
Jul 13, 2021	BINGHAM KATE	SALE	33.50	12	402	39.63K
Jul 13, 2021	LEE KEVIN	SALE	34.00	11.19K	380.6K	251.22K
Jul 12, 2021	LEE KEVIN	SALE	32.04	1.94K	62.03K	254.73K
Jul 12, 2021	CROCKETT NIGEL	SALE	32.03	7.03K	225.11K	0
Jul 06, 2021	CROCKETT NIGEL	SALE	32.00	271	8.67K	0
May 07, 2021	LEE KEVIN	SALE	32.23	5.6K	180.62K	254.73K
May 06, 2021	LEE KEVIN	SALE	32.14	1.72K	55.15K	254.73K
May 04, 2021	LEE KEVIN	SALE	32.03	897	28.73K	254.73K
May 03, 2021	LEE KEVIN	SALE	32.16	3.39K	109.05K	254.73K
Apr 30, 2021	LEE KEVIN	SALE	29.89	3.77K	112.72K	281.37K
Apr 29, 2021	LEE KEVIN	SALE	30.35	4.41K	133.81K	256.34K
Apr 28, 2021	LEE KEVIN	SALE	33.35	200	6.67K	254.73K
Apr 27, 2021	LEE KEVIN	SALE	30.66	6.28K	192.48K	255.09K
Apr 26, 2021	LEE KEVIN	SALE	30.63	4.72K	144.42K	268.63K
Apr 08, 2021	LEGAULT PIERRE	SALE	32.00	12.5K	400K	12.34K
Apr 05, 2021	LEGAULT PIERRE	SALE	31.07	162	5.03K	0
Mar 31, 2021	KEEN NICHOLAS	SALE	30.00	10K	300K	28.32K
Mar 31, 2021	LEGAULT PIERRE	SALE	30.00	10K	300K	0
Mar 17, 2021	LEGAULT PIERRE	SALE	29.00	7.78K	225.74K	0

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES10.84K12

NET SHARES-10.84K12

SHARES HELD1.61M12

% NET SHARES-100.67%0%

Frequently Asked Questions