How many institutions own AVTE stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own AVTE shares is 107, representing 110.8% of the company's common stock.

Who are the major shareholders selling Aerovate Therapeutics, Inc. stock?

STATE STREET CORP, in the last quarter, reduced its stake in AVTE by -1.82% restricting it's holding to 368.54 thousand shares of worth nearly $925.04K. MORGAN STANLEY also lessened -11.07% of the AVTE shares from its portfolio, reducing its holding to 699.44 thousand shares of worth $1.76M. BLACKROCK, INC. also shunned AVTE shares holding by -1.65% last quarter which brought its holding to 959.29 thousand shares worth $2.41M.

Investors who are buying AVTE stock?

As per its latest 13F filing, NORTHERN TRUST CORP increased its stake in AVTE by 2.37% in the last quarter. The institutional holder raised its holding to 109.22 thousand shares having worth more than $274.14K. TWO SIGMA ADVISERS, LP also added 89.97% more shares of AVTE to its portfolio, raising its holding to 291.8 thousand shares of worth $732.42K. GEODE CAPITAL MANAGEMENT, LLC also increased its AVTE shares holding by 0.14% which brought its holding to 295.08 thousand shares worth $740.79K.

AVTE's major insiders: who are they?

The insider with the most stakes in AVTE is RA CAPITAL MANAGEMENT, L.P. , at the company. Additionally, AVTE stock is highly held by director GRAYZEL DAVID S. and CHIEF MEDICAL OFFICER Gillies Hunter among others.

Did an insider recently sell AVTE stock?

Company executives, directors, and other insiders own 0.02% percent of Aerovate Therapeutics, Inc.'s stock. Within the last six months, there have been 0 transaction(s) in which AVTE insiders have sold stock, totaling 0 shares. Insiders that have sold shares include ELDRIDGE GEORGE A, VERWIJS MARINUS, and GILLIES HUNTER.

Which insider recently purchased AVTE stock?

There have been 0 transaction(s) during the past 6-months in which Aerovate Therapeutics, Inc. insiders have bought stock, totalling 0 shares

How much of AVTE does insiders own?

Around 0 Aerovate Therapeutics, Inc. shares are held by insiders, which represents about 0.02% of AVTE stock.

Who is the insider with the largest stake?

AVTE , RA CAPITAL MANAGEMENT, L.P. holds the largest portfolio of the company's shares. AVTE shares owned by RA total nearly 7.89 million.

Which institution holds the most shares in AVTE?

NORTHERN TRUST CORP is the largest institutional owner in AVTE which holds 109.22 thousand shares worth $274.14K or 0.01% of the total AVTE shares outstanding followed by TWO SIGMA ADVISERS, LP with ownership of 291.8 thousand shares representing 0.03% of the AVTE ownership. GEODE CAPITAL MANAGEMENT, LLC is the third largest stakeholder with 295.08 thousand shares or 0.03% of the ownership worth more than $740.79K.

Is Aerovate Therapeutics, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the AVTE is concerned, it is a stock which is optionable.

Is there a short position on AVTE's shares?

Number of AVTE shares short is 131.23K. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding AVTE shares are there?

As of today, 28.98M shares of AVTE are outstanding.

Is there many float in AVTE stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, AVTE has 341.84K shares in float.

AVTE short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for AVTE is 26.71.

Aerovate Therapeutics (AVTE) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableNo

OptionableYes

Short Percent Of Outstanding Shares0.45

Short Percent Of Float1.15

Shares Outstanding28.98M

Shares Float341.84K

Shares Short131.23K

Short Ratio26.71

1.15%

Short % of Float

0.45%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

0.02% Percentage of Shares held by All Insiders

110.8% Percentage of Shares held by All Institutions

110.82% Percentage of Float held by Institutions

107

Number of Institutions Holding Shares

Institutional Ownership

About 110.8% of AVTE shares are held by financial institutions. NORTHERN TRUST CORP is the top corporate investor, holding 109.22K shares valued at $274.14K. A 0.01% stake in Aerovate Therapeutics, Inc. is owned by the company. TWO SIGMA ADVISERS, LP owns 291.8K shares valued at $732.42K, which translates its holding of 0.03% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Mar 31, 2025	NORTHERN TRUST CORP	0.01%	109.22K	274.14K	2.53K	+2.37%
Mar 31, 2025	TWO SIGMA ADVISERS, LP	0.03%	291.8K	732.42K	138.2K	+89.97%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	0.03%	295.08K	740.79K	423	+0.14%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.03%	352.67K	885.2K	38.3K	+12.18%
Mar 31, 2025	DELTEC ASSET MANAGEMENT LLC	0.04%	361.8K	908.13K	167.68K	+86.38%
Mar 31, 2025	STATE STREET CORP	0.04%	368.54K	925.04K	-6.82K	-1.82%
Mar 31, 2025	CABLE CAR CAPITAL LLC	0.06%	589.78K	1.48M	589.78K	+100.00%
Mar 31, 2025	JEFFERIES FINANCIAL GROUP INC.	0.06%	600K	1.51M	0	0
Mar 31, 2025	MORGAN STANLEY	0.07%	699.44K	1.76M	-87.11K	-11.07%
Mar 31, 2025	AFFINITY ASSET ADVISORS, LLC	0.08%	800K	2.01M	0	0
Mar 31, 2025	BLACKSTONE INC.	0.09%	955.13K	2.4M	455.56K	+91.19%
Mar 31, 2025	BLACKROCK, INC.	0.09%	959.29K	2.41M	-16.13K	-1.65%
Mar 31, 2025	VANGUARD GROUP INC	0.11%	1.07M	2.68M	65.1K	+6.50%
Mar 31, 2025	LOGOS GLOBAL MANAGEMENT LP	0.14%	1.4M	3.51M	0	0
Mar 31, 2025	ALLOSTERY INVESTMENTS LP	0.14%	1.42M	3.57M	570.88K	+67.11%
Mar 31, 2025	BRAIDWELL LP	0.14%	1.44M	3.62M	0	0
Mar 31, 2025	ADAR1 CAPITAL MANAGEMENT, LLC	0.14%	1.46M	3.67M	533.22K	+57.46%
Mar 31, 2025	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	0.18%	1.8M	4.52M	0	0
Mar 31, 2025	TCG CROSSOVER MANAGEMENT, LLC	0.22%	2.24M	5.62M	0	0
Mar 31, 2025	SOFINNOVA INVESTMENTS, INC.	0.37%	3.76M	9.43M	0	0
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	0.91%	9.19M	23.07M	0	0
Mar 31, 2025	RHUMBLINE ADVISERS	0%	22.75K	57.09K	9.15K	+67.33%
Mar 31, 2025	GROUP ONE TRADING, L.P.	0%	37.05K	92.99K	-102.8K	-73.51%
Mar 31, 2025	KOVITZ INVESTMENT GROUP PARTNERS, LLC	0%	26.51K	66.55K	26.51K	+100.00%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0%	36.53K	91.69K	-1.14K	-3.03%
Mar 31, 2025	ACADIAN ASSET MANAGEMENT LLC	0%	15.98K	40K	-69.81K	-81.37%
Mar 31, 2025	CITIGROUP INC	0%	17.19K	43.14K	972	+5.99%
Mar 31, 2025	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0%	25K	62.75K	-35K	-58.33%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0%	30.43K	76.37K	-35.27K	-53.69%
Mar 31, 2025	CITADEL ADVISORS LLC	0%	31.46K	78.96K	25.91K	+466.67%
Mar 31, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0%	32.4K	81.31K	17.21K	+113.35%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.01%	54K	135.54K	9.4K	+21.08%
Mar 31, 2025	VERITION FUND MANAGEMENT LLC	0.01%	55.52K	139.36K	-39.12K	-41.33%
Mar 31, 2025	ALLIANCEBERNSTEIN L.P.	0.01%	69.91K	175.47K	0	0
Mar 31, 2025	XTX TOPCO LTD	0%	18.74K	47.04K	-5.01K	-21.08%
Mar 31, 2025	AQR CAPITAL MANAGEMENT LLC	0%	21.63K	54.3K	2.78K	+14.74%
Mar 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0%	23.07K	57.9K	-31.62K	-57.82%
Mar 31, 2025	HARVEST INVESTMENT SERVICES, LLC	0%	23.92K	60.52K	0	0
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0%	28K	70.28K	-40.2K	-58.94%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0%	29.35K	73.67K	0	0
Mar 31, 2025	INVESCO LTD.	0.01%	74.44K	186.85K	74.44K	+100.00%
Mar 31, 2025	JPMORGAN CHASE & CO	0.01%	75.67K	189.94K	8.51K	+12.67%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.02%	204.79K	514.03K	-21.33K	-9.43%
Mar 31, 2025	BANK OF MONTREAL /CAN/	0.01%	59.1K	148.33K	0	0
Mar 31, 2025	TANG CAPITAL MANAGEMENT LLC	0.01%	69.75K	175.08K	69.75K	+100.00%
Mar 31, 2025		0%	40.05K	100.52K	40.05K	+100.00%
Mar 31, 2025	GTS SECURITIES LLC	0%	25.14K	63.11K	15.06K	+149.39%
Mar 31, 2025	NUVEEN, LLC	0%	40.05K	100.52K	40.05K	+100.00%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.02%	246.91K	619.75K	15.83K	+6.85%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.05%	13.1K	387.37K	0	0
Mar 31, 2024	JUMP FINANCIAL, LLC	0.03%	9.6K	283.87K	9.6K	+100.00%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.03%	7.5K	222K	7.5K	+100.00%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.03%	7.12K	210.66K	7.12K	+100.00%
Mar 31, 2024	AMERICAN INTERNATIONAL GROUP, INC.	0.02%	5.51K	162.9K	-47	-0.85%
Mar 31, 2024	METLIFE INVESTMENT MANAGEMENT, LLC	0.02%	5.23K	154.59K	0	0
Mar 31, 2024	QUEST PARTNERS LLC	0.02%	4.63K	136.79K	4.63K	+100.00%
Mar 31, 2024	JPMORGAN CHASE & CO	0.02%	4.59K	135.76K	-2.89K	-38.59%
Mar 31, 2024	NEW YORK STATE COMMON RETIREMENT FUND	0.02%	4.31K	128K	9	+0.21%
Mar 31, 2024	WELLS FARGO & COMPANY/MN	0.01%	3.36K	99.41K	448	+15.37%
Mar 31, 2024	ENTRYPOINT CAPITAL, LLC	0.01%	3.13K	92.44K	-3.01K	-49.03%
Mar 31, 2024	CITIGROUP INC	0.01%	2.55K	75.31K	452	+21.58%
Mar 31, 2024	STRS OHIO	0.01%	2.2K	65K	-100	-4.35%
Mar 31, 2024	LEGAL & GENERAL GROUP PLC	0%	1.18K	34.8M	-489	-29.35%
Mar 31, 2024	AMERITAS INVESTMENT PARTNERS, INC.	0%	772	22.83M	0	0
Mar 31, 2024	METROPOLITAN LIFE INSURANCE CO/NY	0%	701	20.73K	0	0
Mar 31, 2024	FORTITUDE FAMILY OFFICE, LLC	0%	416	12.3K	0	0
Mar 31, 2024	AMALGAMATED BANK	0%	347	10K	-1.09K	-75.77%
Mar 31, 2024	GAMMA INVESTING LLC	0%	94	2.78K	14	+17.50%
Mar 31, 2024	FEDERATED HERMES, INC.	0%	60	1.77K	60	+100.00%
Mar 31, 2024	NISA INVESTMENT ADVISORS, LLC	0%	7	207	7	+100.00%
Mar 31, 2024	RUSSELL INVESTMENTS GROUP, LTD.	0%	7	207	7	+100.00%
Mar 31, 2024	NELSON, VAN DENBURG & CAMPBELL WEALTH MANAGEMENT GROUP, LLC	0%	2	59	2	+100.00%
Mar 31, 2024	HRT FINANCIAL LP	0%	0	-	-9.43K	-100.00%
Mar 31, 2024	VESTAL POINT CAPITAL, LP	0%	0	-	-400K	-100.00%
Mar 31, 2024	RA CAPITAL MANAGEMENT, L.P.	29.84%	8.26M	244.37M	0	0
Mar 31, 2024	SOFINNOVA INVESTMENTS, INC.	13.57%	3.76M	111.14M	0	0
Mar 31, 2024	TCG CROSSOVER MANAGEMENT, LLC	7.95%	2.2M	65.09M	0	0
Mar 31, 2024	BAKER BROS. ADVISORS LP	6.07%	1.68M	49.69M	0	0
Mar 31, 2024	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	4.35%	1.2M	35.63M	0	0
Mar 31, 2024	CORMORANT ASSET MANAGEMENT, LP	3.86%	1.07M	31.63M	-141.9K	-11.71%
Mar 31, 2024	GREAT POINT PARTNERS LLC	3.21%	887.69K	26.25M	-150K	-14.46%
Mar 31, 2024	FMR LLC	1.94%	537.53K	15.89M	44	+0.01%
Mar 31, 2024	EVERSEPT PARTNERS, LP	0.2%	54.15K	1.6M	3.91K	+7.78%
Mar 31, 2024	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	7.36%	2.04M	60.3M	0	0
Mar 31, 2024	BLACKROCK INC.	2.56%	709.75K	20.99M	-17.7K	-2.43%
Mar 31, 2024	VANGUARD GROUP INC	2.43%	672.28K	19.88M	45.44K	+7.25%
Mar 31, 2024	D. E. SHAW & CO., INC.	0.06%	17.27K	510.53K	17.27K	+100.00%
Mar 31, 2024	ADAR1 CAPITAL MANAGEMENT, LLC	0.06%	15.9K	470.16K	15.9K	+100.00%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	0.05%	14.96K	442.28K	0	0
Mar 31, 2024	RHUMBLINE ADVISERS	0.05%	14.62K	432.36K	465	+3.28%
Mar 31, 2024	PDT PARTNERS, LLC	0.05%	12.68K	374.95K	12.68K	+100.00%
Mar 31, 2024	JANE STREET GROUP, LLC	0.04%	11.26K	333.08K	-1.84K	-14.05%
Mar 31, 2024	UBS GROUP AG	0.04%	11.24K	332.28K	-1K	-8.20%
Mar 31, 2024	DRIEHAUS CAPITAL MANAGEMENT LLC	2.87%	794.99K	23.51M	-263.22K	-24.87%
Mar 31, 2024	ORBIMED ADVISORS LLC	2.04%	565.37K	16.72M	-191.56K	-25.31%
Mar 31, 2024	EVENTIDE ASSET MANAGEMENT, LLC	1.61%	445.5K	13.17M	433.32K	+3,558.24%
Mar 31, 2024	OCTAGON CAPITAL ADVISORS LP	1.46%	403.69K	11.94M	0	0
Mar 31, 2024	POINT72 ASSET MANAGEMENT, L.P.	1.44%	399.82K	11.82M	-41.65K	-9.43%
Mar 31, 2024	IKARIAN CAPITAL, LLC	1.33%	367.97K	10.88M	367.97K	+100.00%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	1.02%	281.76K	8.33M	4.87K	+1.76%
Mar 31, 2024	ENSIGN PEAK ADVISORS, INC	0.95%	262.26K	7.75M	140K	+114.51%
Mar 31, 2024	STATE STREET CORP	0.83%	229.99K	6.8M	15.96K	+7.46%
Mar 31, 2024	GHOST TREE CAPITAL, LLC	0.81%	225K	6.65M	15K	+7.14%
Mar 31, 2024	WOODLINE PARTNERS LP	0.72%	200K	5.91M	200K	+100.00%
Mar 31, 2024	SUPERSTRING CAPITAL MANAGEMENT LP	0.4%	110.26K	3.26M	110.26K	+100.00%
Mar 31, 2024	NORTHERN TRUST CORP	0.36%	98.56K	2.91M	-968	-0.97%
Mar 31, 2024	EXOME ASSET MANAGEMENT LLC	0.36%	98.49K	2.91M	98.49K	+100.00%
Mar 31, 2024	BOOTHBAY FUND MANAGEMENT, LLC	0.35%	97.84K	2.89M	97.84K	+100.00%
Mar 31, 2024	NANTAHALA CAPITAL MANAGEMENT, LLC	0.33%	91.19K	2.7M	0	0
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	0.23%	62.56K	1.85M	62.56K	+100.00%
Mar 31, 2024	WALLEYE CAPITAL LLC	0.2%	54.52K	1.61M	54.52K	+100.00%
Mar 31, 2024	NAN FUNG GROUP HOLDINGS LTD	0.17%	47.94K	1.42M	0	0
Mar 31, 2024	SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)	0.16%	44.32K	1.31M	-6.55K	-12.87%
Mar 31, 2024	FRED ALGER MANAGEMENT, LLC	0.16%	43.79K	1.29M	7.31K	+20.05%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.14%	40.05K	1.18M	0	0
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.11%	30.96K	915.43K	1.42K	+4.79%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.1%	27.66K	818.03K	-8.89K	-24.33%
Mar 31, 2024	MORGAN STANLEY	0.09%	26.28K	777.19K	-8.77K	-25.02%
Mar 31, 2024	SHAY CAPITAL LLC	0.09%	24.59K	727.07K	24.59K	+100.00%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.08%	22.91K	677.54K	13.15K	+134.76%
Mar 31, 2024	PRELUDE CAPITAL MANAGEMENT, LLC	0.07%	20.69K	611.66K	20.69K	+100.00%
Mar 31, 2024	ALPS ADVISORS INC	0.07%	19.52K	577.18K	801	+4.28%
Mar 31, 2024	PARKWOOD LLC	0.06%	17.73K	524K	1.94K	+12.30%
Dec 31, 2023	EVERSEPT PARTNERS, LP	0.18%	50.24K	1.14M	0	0
Dec 31, 2023	NAN FUNG GROUP HOLDINGS LTD	0.17%	47.94K	1.08M	0	0
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.14%	40.05K	906.26K	3.74K	+10.29%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.13%	36.56K	827.31K	9.15K	+33.36%
Dec 31, 2023	FRED ALGER MANAGEMENT, LLC	0.13%	36.48K	825.5K	11.73K	+47.40%
Dec 31, 2023	MORGAN STANLEY	0.13%	35.05K	793.23K	16K	+83.97%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.11%	29.54K	668.54K	0	0
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.08%	22.7K	513.66K	12.39K	+120.26%
Dec 31, 2023	ALPS ADVISORS INC	0.07%	18.72K	423.59K	-1.68K	-8.22%
Dec 31, 2023	PARKWOOD LLC	0.06%	15.79K	357K	-4.87K	-23.57%
Dec 31, 2023	BARCLAYS PLC	0.06%	15.39K	348K	11.55K	+300.26%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	0.05%	14.96K	338.88K	-5.59K	-27.20%
Dec 31, 2023	RHUMBLINE ADVISERS	0.05%	14.16K	320.36K	164	+1.17%
Dec 31, 2023	JANE STREET GROUP, LLC	0.05%	13.11K	296.59K	13.11K	+100.00%
Dec 31, 2023	EVENTIDE ASSET MANAGEMENT, LLC	0.04%	12.18K	275.59K	12.18K	+100.00%
Dec 31, 2023	GOLDEN STATE EQUITY PARTNERS	0.04%	10.88K	246.21K	350	+3.32%
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	0.04%	9.76K	220.87K	-2.04K	-17.32%
Dec 31, 2023	HRT FINANCIAL LP	0.03%	9.43K	213K	9.43K	+100.00%
Dec 31, 2023	JPMORGAN CHASE & CO	0.03%	7.48K	169.18K	57	+0.77%
Dec 31, 2023	AMERICAN INTERNATIONAL GROUP, INC.	0.02%	5.56K	125.73K	-23	-0.41%
Dec 31, 2023	METLIFE INVESTMENT MANAGEMENT, LLC	0.02%	5.23K	118.31K	0	0
Dec 31, 2023	DEUTSCHE BANK AG\	0.02%	4.99K	112.81K	0	0
Dec 31, 2023	UBS GROUP AG	0.04%	12.24K	277.01K	1.03K	+9.16%
Dec 31, 2023	RA CAPITAL MANAGEMENT, L.P.	29.9%	8.26M	187.01M	0	0
Dec 31, 2023	SOFINNOVA INVESTMENTS, INC.	13.6%	3.76M	85.06M	0	0
Dec 31, 2023	TCG CROSSOVER MANAGEMENT, LLC	7.96%	2.2M	49.81M	0	0
Dec 31, 2023	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	7.38%	2.04M	46.15M	0	0
Dec 31, 2023	BAKER BROS. ADVISORS LP	6.08%	1.68M	38.03M	-282.96K	-14.41%
Dec 31, 2023	CORMORANT ASSET MANAGEMENT, LP	4.38%	1.21M	27.42M	-350K	-22.41%
Dec 31, 2023	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	4.36%	1.2M	27.27M	0	0
Dec 31, 2023	DRIEHAUS CAPITAL MANAGEMENT LLC	3.83%	1.06M	23.95M	-129.41K	-10.90%
Dec 31, 2023	GREAT POINT PARTNERS LLC	3.75%	1.04M	23.48M	-53.54K	-4.91%
Dec 31, 2023	ORBIMED ADVISORS LLC	2.74%	756.93K	17.13M	0	0
Dec 31, 2023	BLACKROCK INC.	2.63%	727.45K	16.46M	44.67K	+6.54%
Dec 31, 2023	VANGUARD GROUP INC	2.27%	626.83K	14.19M	27.73K	+4.63%
Dec 31, 2023	FMR LLC	1.94%	537.49K	12.16M	7.94K	+1.50%
Dec 31, 2023	POINT72 ASSET MANAGEMENT, L.P.	1.6%	441.47K	9.99M	441.47K	+100.00%
Dec 31, 2023	OCTAGON CAPITAL ADVISORS LP	1.46%	403.69K	9.14M	-93.69K	-18.84%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1%	276.9K	6.27M	27.09K	+10.84%
Dec 31, 2023	STATE STREET CORP	0.77%	214.03K	4.84M	32.52K	+17.92%
Dec 31, 2023	GHOST TREE CAPITAL, LLC	0.76%	210K	4.75M	8.8K	+4.38%
Dec 31, 2023	PARADIGM BIOCAPITAL ADVISORS LP	0.52%	143.24K	3.24M	143.24K	+100.00%
Dec 31, 2023	NORTHERN TRUST CORP	0.36%	99.53K	2.25M	-10.92K	-9.88%
Dec 31, 2023		0.02%	6.13K	138.79K	6.13K	+100.00%
Dec 31, 2023	ENSIGN PEAK ADVISORS, INC	0.44%	122.26K	2.77M	107.26K	+715.05%
Dec 31, 2023	HUDSON BAY CAPITAL MANAGEMENT LP	0.37%	103K	2.33M	103K	+100.00%
Dec 31, 2023	ALLIANCEBERNSTEIN L.P.	0.05%	13.1K	296.45K	650	+5.22%
Dec 31, 2023	NANTAHALA CAPITAL MANAGEMENT, LLC	0.33%	91.19K	2.06M	-3.81K	-4.01%
Dec 31, 2023	SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)	0.18%	50.87K	1.15M	0	0
Sep 30, 2023	RUSSELL INVESTMENTS GROUP, LTD.	0%	0	-	-939	-100.00%
Sep 30, 2023	NISA INVESTMENT ADVISORS, LLC	0%	0	-	-7	-100.00%
Sep 30, 2023	CITIGROUP INC	0%	213	-	-3.11K	-93.59%
Sep 30, 2023	METROPOLITAN LIFE INSURANCE CO/NY	0%	701	-	0	0
Sep 30, 2023	AMERITAS INVESTMENT PARTNERS, INC.	0%	772	-	0	0
Sep 30, 2023	ROYAL BANK OF CANADA	0.01%	1.4K	-	520	+59.09%
Sep 30, 2023	TOWER RESEARCH CAPITAL LLC (TRC)	0.01%	1.44K	-	532	+58.59%
Sep 30, 2023	AMALGAMATED BANK	0.01%	1.54K	-	0	0
Sep 30, 2023	WELLS FARGO & COMPANY/MN	0.01%	2.25K	-	-1.95K	-46.33%
Sep 30, 2023	STRS OHIO	0.01%	2.3K	-	0	0
Sep 30, 2023	BARCLAYS PLC	0.02%	3.85K	-	440	+12.92%
Sep 30, 2023	NEW YORK STATE COMMON RETIREMENT FUND	0.02%	4.32K	-	45	+1.05%
Sep 30, 2023	DEUTSCHE BANK AG\	0.02%	4.99K	-	0	0
Sep 30, 2023	METLIFE INVESTMENT MANAGEMENT, LLC	0.02%	5.23K	-	0	0
Sep 30, 2023	AMERICAN INTERNATIONAL GROUP, INC.	0.02%	5.58K	-	735	+15.17%
Sep 30, 2023	GOLDEN STATE EQUITY PARTNERS	0.04%	10.53K	-	0	0
Sep 30, 2023	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0.04%	11.01K	-	1.12K	+11.28%
Sep 30, 2023	UBS GROUP AG	0.04%	11.21K	-	8.22K	+273.92%
Sep 30, 2023	TWO SIGMA INVESTMENTS, LP	0.05%	11.8K	-	-18.21K	-60.67%
Sep 30, 2023	ALLIANCEBERNSTEIN L.P.	0.05%	12.45K	-	730	+6.23%
Sep 30, 2023	RHUMBLINE ADVISERS	0.06%	13.99K	-	1.01K	+7.75%
Sep 30, 2023	ENSIGN PEAK ADVISORS, INC	0.06%	15K	-	0	0
Sep 30, 2023	MORGAN STANLEY	0.08%	19.05K	-	-13.97K	-42.31%
Sep 30, 2023	ALPS ADVISORS INC	0.08%	20.4K	-	2.08K	+11.33%
Sep 30, 2023	DIMENSIONAL FUND ADVISORS LP	0.08%	20.55K	-	-4.47K	-17.85%
Sep 30, 2023	PARKWOOD LLC	0.08%	20.65K	-	-2.18K	-9.54%
Sep 30, 2023	SWISS NATIONAL BANK	0.08%	21.2K	-	5K	+30.86%
Sep 30, 2023	FRED ALGER MANAGEMENT, LLC	0.1%	24.75K	-	-33.13K	-57.24%
Sep 30, 2023	BANK OF NEW YORK MELLON CORP	0.11%	27.41K	-	180	+0.66%
Sep 30, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.12%	29.54K	-	2.87K	+10.76%
Sep 30, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.14%	36.31K	-	0	0
Sep 30, 2023	NAN FUNG GROUP HOLDINGS LTD	0.19%	47.94K	-	0	0
Sep 30, 2023	EVERSEPT PARTNERS, LP	0.2%	50.24K	-	0	0
Sep 30, 2023	SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)	0.2%	50.87K	-	0	0
Sep 30, 2023	SILVERARC CAPITAL MANAGEMENT, LLC	0.4%	100K	-	100K	+100.00%
Sep 30, 2023	NORTHERN TRUST CORP	0.44%	110.44K	-	22.45K	+25.51%
Sep 30, 2023	GEODE CAPITAL MANAGEMENT, LLC	0.99%	249.81K	-	46.75K	+23.02%
Sep 30, 2023	FMR LLC	2.1%	529.54K	-	-198.07K	-27.22%
Sep 30, 2023	OUP MANAGEMENT CO., LLC	2.4%	603.76K	-	0	0
Sep 30, 2023	BLACKROCK INC.	2.71%	682.78K	-	60.13K	+9.66%
Sep 30, 2023	ORBIMED ADVISORS LLC	3.01%	756.93K	-	0	0
Sep 30, 2023	DRIEHAUS CAPITAL MANAGEMENT LLC	4.72%	1.19M	-	-6.47K	-0.54%
Sep 30, 2023	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	4.79%	1.2M	-	210.01K	+21.11%
Sep 30, 2023	CORMORANT ASSET MANAGEMENT, LP	6.21%	1.56M	-	0	0
Sep 30, 2023	BAKER BROS. ADVISORS LP	7.8%	1.96M	-	0	0
Sep 30, 2023	ATLAS VENTURE LIFE SCIENCE ADVISORS, LLC	8.1%	2.04M	-	0	0
Sep 30, 2023	RA CAPITAL MANAGEMENT, L.P.	32.84%	8.26M	-	0	0
Sep 30, 2023	HIGHVISTA STRATEGIES LLC	0%	0	-	-41.8K	-100.00%

Insiders

Among the AVTE insiders holding of 0.02% of the stake in company, RA CAPITAL MANAGEMENT, L.P., , holds the largest shares of 7.89M. GRAYZEL DAVID S., director, is the second largest AVTE insider with ownership of 14.5K shares. GILLIES HUNTER, CHIEF MEDICAL OFFICER, stands third with possession of 5.6K shares of that stake.

Insiders	Designation	Shares Held
RA CAPITAL MANAGEMENT, L.P.		7.89M
GRAYZEL DAVID S.	director	14.5K
GILLIES HUNTER	CHIEF MEDICAL OFFICER	5.6K
ELDRIDGE GEORGE A	SEE REMARKS	5.02K
NIVEN RALPH	CHIEF SCIENTIFIC OFFICER	1.61K
DAKE BENJAMIN T	SEE REMARKS	1.29K
VERWIJS MARINUS	CHIEF TECHNICAL OFFICER	0
NOYES TIMOTHY P	CHIEF EXECUTIVE OFFICER	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Jun 17, 2024	RA CAPITAL MANAGEMENT, L.P.	PURCHASE	1.67	928.11K	1.55M	7.89M
Jun 14, 2024	ELDRIDGE GEORGE A	SALE	25.03	15K	375.45K	5.02K
Jun 14, 2024	VERWIJS MARINUS	SALE	25.00	10.6K	265K	0
Jun 13, 2024	GILLIES HUNTER	SALE	24.50	6K	147K	5.6K
May 17, 2024	GILLIES HUNTER	SALE	21.86	86	1.88K	5.6K
May 16, 2024	NOYES TIMOTHY P	SALE	21.92	1.29K	28.35K	0
May 02, 2024	VERWIJS MARINUS	SALE	21.02	1.98K	41.63K	0
May 01, 2024	NOYES TIMOTHY P	SALE	19.91	1.36K	27.02K	0
Apr 17, 2024	DAKE BENJAMIN T	SALE	23.97	68	1.63K	1.29K
Apr 17, 2024	GILLIES HUNTER	SALE	23.33	311	7.25K	3.25K
Apr 16, 2024	NOYES TIMOTHY P	SALE	24.94	5.51K	137.41K	0
Apr 10, 2024	ELDRIDGE GEORGE A	SALE	27.56	771	21.25K	1.96K
Apr 09, 2024	GRAYZEL DAVID S.	SALE	28.15	11.88K	334.48K	14.5K
Apr 01, 2024	DAKE BENJAMIN T	SALE	31.97	3.33K	106.32K	1.29K
Apr 01, 2024	VERWIJS MARINUS	SALE	30.00	1.5K	45.12K	0
Apr 01, 2024	ELDRIDGE GEORGE A	SALE	31.23	12.5K	390.21K	1.96K
Apr 01, 2024	NOYES TIMOTHY P	SALE	31.95	1K	31.95K	0
Mar 28, 2024	GILLIES HUNTER	SALE	29.50	9K	265.5K	3.25K
Mar 27, 2024	DAKE BENJAMIN T	SALE	27.97	11.07K	309.52K	1.29K
Mar 25, 2024	DAKE BENJAMIN T	SALE	28.01	3.43K	96.12K	1.29K
Mar 19, 2024	VERWIJS MARINUS	SALE	26.46	2.76K	73.12K	0
Mar 18, 2024	GILLIES HUNTER	SALE	26.40	613	16.18K	3.25K
Mar 18, 2024	DAKE BENJAMIN T	SALE	26.48	7.58K	200.76K	1.29K
Mar 13, 2024	ELDRIDGE GEORGE A	SALE	25.02	2.02K	50.44K	1.96K
Mar 12, 2024	ELDRIDGE GEORGE A	SALE	25.05	2.05K	51.37K	1.96K
Mar 11, 2024	ELDRIDGE GEORGE A	SALE	26.30	10	263.05	1.96K
Mar 08, 2024	ELDRIDGE GEORGE A	SALE	25.00	114	2.85K	1.96K
Mar 07, 2024	ELDRIDGE GEORGE A	SALE	25.00	22.39K	559.69K	1.96K
Mar 07, 2024	GILLIES HUNTER	SALE	24.50	8.98K	219.89K	3.25K
Feb 23, 2024	GILLIES HUNTER	SALE	19.50	511	9.96K	3.25K
Feb 20, 2024	GILLIES HUNTER	SALE	20.58	898	18.48K	3.25K
Feb 05, 2024	NIVEN RALPH	SALE	17.45	4.6K	80.25K	1.61K
Jan 17, 2024	GILLIES HUNTER	SALE	19.50	4K	78K	3.25K
Jan 05, 2024	NIVEN RALPH	SALE	19.57	2.47K	48.42K	1.61K
Dec 27, 2023	GILLIES HUNTER	SALE	24.50	125	3.06K	3.25K
Dec 20, 2023	GILLIES HUNTER	SALE	19.50	4K	78K	3.25K
Dec 14, 2023	GILLIES HUNTER	SALE	19.50	9.9K	192.99K	3.25K
Dec 06, 2023	DAKE BENJAMIN T	SALE	16.11	10.28K	165.63K	1.29K
Dec 05, 2023	NIVEN RALPH	SALE	16.30	4.6K	75K	1.61K
Nov 27, 2023	DAKE BENJAMIN T	SALE	16.24	12.52K	203.24K	1.29K
Nov 24, 2023	DAKE BENJAMIN T	SALE	16.07	70	1.12K	1.29K
Nov 22, 2023	NIVEN RALPH	SALE	15.00	13.8K	207K	1.61K
Nov 22, 2023	DAKE BENJAMIN T	SALE	15.17	9.38K	142.36K	1.29K
Nov 01, 2023	NOYES TIMOTHY P	SALE	10.42	1.09K	11.38K	0
Nov 01, 2023	VERWIJS MARINUS	SALE	10.46	970	10.15K	0
Sep 07, 2023	DAKE BENJAMIN T	SALE	15.01	30	450.3	1.29K
Sep 06, 2023	DAKE BENJAMIN T	SALE	15.06	3.93K	59.19K	1.29K
Aug 07, 2023	DAKE BENJAMIN T	SALE	16.25	541	8.79K	1.29K
Jul 28, 2023	NOYES TIMOTHY P	SALE	18.00	5.48K	98.6K	0
Jul 17, 2023	NOYES TIMOTHY P	SALE	18.11	4.52K	81.9K	0
Jul 06, 2023	DAKE BENJAMIN T	SALE	16.66	10.28K	171.28K	1.29K
Jul 05, 2023	NIVEN RALPH	SALE	17.87	219	3.91K	1.61K
Jul 03, 2023	NOYES TIMOTHY P	SALE	18.00	10K	180K	0
Jun 06, 2023	DAKE BENJAMIN T	SALE	16.98	15	254.63	1.29K
Jun 05, 2023	NIVEN RALPH	SALE	16.26	2.25K	36.58K	1.61K
May 19, 2023	GILLIES HUNTER	SALE	19.50	65	1.27K	3.25K
May 17, 2023	GILLIES HUNTER	SALE	19.59	1.09K	21.36K	3.25K
May 08, 2023	DAKE BENJAMIN T	SALE	22.74	1.6K	36.35K	1.29K
May 05, 2023	NIVEN RALPH	SALE	21.63	205	4.44K	1.61K
May 03, 2023	VERWIJS MARINUS	SALE	20.79	759	15.78K	0
May 02, 2023	NOYES TIMOTHY P	SALE	21.15	693	14.66K	0
May 01, 2023	NOYES TIMOTHY P	SALE	20.61	15K	309.09K	693
Apr 21, 2023	GILLIES HUNTER	SALE	19.50	4K	78K	1.96K
Apr 06, 2023	DAKE BENJAMIN T	SALE	18.17	10.28K	186.83K	0
Apr 05, 2023	NIVEN RALPH	SALE	19.11	535	10.22K	1.61K
Apr 03, 2023	NOYES TIMOTHY P	SALE	19.77	5.83K	115.23K	0
Mar 06, 2023	DAKE BENJAMIN T	SALE	24.50	215	5.27K	0
Mar 06, 2023	NIVEN RALPH	SALE	24.92	45	1.12K	1.61K
Mar 01, 2023	NOYES TIMOTHY P	SALE	24.69	5.32K	131.24K	1.05K
Feb 06, 2023	NIVEN RALPH	SALE	24.27	2.25K	54.61K	1.61K
Feb 06, 2023	DAKE BENJAMIN T	SALE	25.02	1.43K	35.68K	0
Feb 01, 2023	NOYES TIMOTHY P	SALE	23.05	4.5K	103.61K	0
Jan 06, 2023	DAKE BENJAMIN T	SALE	26.95	2.79K	75.25K	0
Jan 05, 2023	NIVEN RALPH	SALE	26.40	2.25K	59.4K	1.61K
Jan 03, 2023	NOYES TIMOTHY P	SALE	26.80	11.93K	319.61K	3.07K
Dec 12, 2022	DAKE BENJAMIN T	SALE	25.82	20	516.4	2.04K
Dec 12, 2022	ELDRIDGE GEORGE A	SALE	30.04	10K	300.43K	1.96K
Dec 09, 2022	DAKE BENJAMIN T	SALE	25.03	394	9.86K	0
Dec 09, 2022	ELDRIDGE GEORGE A	SALE	24.23	3.39K	82.05K	2.54K
Dec 08, 2022	ELDRIDGE GEORGE A	SALE	20.12	960	19.31K	13.01K
Dec 08, 2022	DAKE BENJAMIN T	SALE	20.94	928	19.44K	9.07K
Dec 07, 2022	ELDRIDGE GEORGE A	SALE	19.37	7.08K	137.09K	6.52K
Dec 06, 2022	DAKE BENJAMIN T	SALE	15.61	2.01K	31.39K	37.99K
Dec 05, 2022	NIVEN RALPH	SALE	17.38	2.25K	39.11K	1.61K
Dec 01, 2022	NOYES TIMOTHY P	SALE	18.00	15K	270K	0
Nov 30, 2022	ELDRIDGE GEORGE A	SALE	19.06	85	1.62K	1.96K
Nov 23, 2022	ELDRIDGE GEORGE A	SALE	19.07	1.26K	24.05K	1.96K
Nov 22, 2022	ELDRIDGE GEORGE A	SALE	19.01	174	3.31K	1.96K
Nov 18, 2022	ELDRIDGE GEORGE A	SALE	19.45	780	15.17K	2.04K
Nov 11, 2022	DAKE BENJAMIN T	SALE	20.39	4.45K	90.75K	1.75K
Nov 08, 2022	DAKE BENJAMIN T	SALE	18.09	8.37K	151.46K	0
Nov 07, 2022	DAKE BENJAMIN T	SALE	17.79	11.12K	197.82K	6.51K
Nov 07, 2022	NIVEN RALPH	SALE	17.09	450	7.69K	3.41K
Nov 02, 2022	VERWIJS MARINUS	SALE	18.89	1.13K	21.35K	0
Nov 01, 2022	NOYES TIMOTHY P	SALE	19.50	1.04K	20.24K	0
Oct 18, 2022	DAKE BENJAMIN T	SALE	21.08	5.71K	120.29K	0
Oct 17, 2022	DAKE BENJAMIN T	SALE	20.16	4.19K	84.38K	0
Oct 10, 2022	DAKE BENJAMIN T	SALE	16.74	3.52K	58.99K	1.43K
Oct 07, 2022	DAKE BENJAMIN T	SALE	15.93	8.76K	139.63K	1.76K
Oct 06, 2022	DAKE BENJAMIN T	SALE	15.64	11.21K	175.34K	1.83K

Frequently Asked Questions