How many institutions own ARQT stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own ARQT shares is 333, representing 108.2% of the company's common stock.

Who are the major shareholders selling Arcutis Biotherapeutics, Inc. stock?

D. E. SHAW & CO., INC., in the last quarter, reduced its stake in ARQT by -2.05% restricting it's holding to 2.12 million shares of worth nearly $39.94M. FRANKLIN RESOURCES INC also lessened -15.43% of the ARQT shares from its portfolio, reducing its holding to 2.31 million shares of worth $43.56M. MORGAN STANLEY also shunned ARQT shares holding by -0.88% last quarter which brought its holding to 4.28 million shares worth $80.61M.

Investors who are buying ARQT stock?

As per its latest 13F filing, PERPETUAL LTD increased its stake in ARQT by 7,534.26% in the last quarter. The institutional holder raised its holding to 2.02 million shares having worth more than $38.16M. DRIEHAUS CAPITAL MANAGEMENT LLC also added 1.02% more shares of ARQT to its portfolio, raising its holding to 1.1 million shares of worth $20.68M. JANUS HENDERSON GROUP PLC also increased its ARQT shares holding by 5.92% which brought its holding to 2.4 million shares worth $45.18M.

ARQT's major insiders: who are they?

The insider with the most stakes in ARQT is Frazier Life Sciences VIII, L.P. , 10 percent owner at the company. Additionally, ARQT stock is highly held by See Remarks Watanabe Todd Franklin and See Remarks Watanabe Todd among others.

Did an insider recently sell ARQT stock?

Company executives, directors, and other insiders own 1.68% percent of Arcutis Biotherapeutics, Inc.'s stock. Within the last six months, there have been 37 transaction(s) in which ARQT insiders have sold stock, totaling 373.65K shares. Insiders that have sold shares include BURNETT PATRICK, EDWARDS LARRY TODD, and WATANABE TODD.

Which insider recently purchased ARQT stock?

There have been 0 transaction(s) during the past 6-months in which Arcutis Biotherapeutics, Inc. insiders have bought stock, totalling 0 shares

How much of ARQT does insiders own?

Around 10.12M Arcutis Biotherapeutics, Inc. shares are held by insiders, which represents about 1.68% of ARQT stock.

Who is the insider with the largest stake?

ARQT 10 percent owner, Frazier Life Sciences VIII, L.P. holds the largest portfolio of the company's shares. ARQT shares owned by Frazier total nearly 8.76 million.

Which institution holds the most shares in ARQT?

PERPETUAL LTD is the largest institutional owner in ARQT which holds 2.02 million shares worth $38.16M or 1.59% of the total ARQT shares outstanding followed by DRIEHAUS CAPITAL MANAGEMENT LLC with ownership of 1.1 million shares representing 0.86% of the ARQT ownership. D. E. SHAW & CO., INC. is the third largest stakeholder with 2.12 million shares or 1.67% of the ownership worth more than $39.94M.

Is Arcutis Biotherapeutics, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the ARQT is concerned, it is a stock which is optionable.

Is there a short position on ARQT's shares?

Number of ARQT shares short is 12.06M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding ARQT shares are there?

As of today, 122.49M shares of ARQT are outstanding.

Is there many float in ARQT stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, ARQT has 89.41M shares in float.

ARQT short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for ARQT is 3.77.

Arcutis Biotherapeutics (ARQT) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares9.85

Short Percent Of Float12.1

Shares Outstanding122.49M

Shares Float89.41M

Shares Short12.06M

Short Ratio3.77

12.1%

Short % of Float

9.85%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

1.68% Percentage of Shares held by All Insiders

108.2% Percentage of Shares held by All Institutions

110.05% Percentage of Float held by Institutions

333

Number of Institutions Holding Shares

Institutional Ownership

About 108.2% of ARQT shares are held by financial institutions. PERPETUAL LTD is the top corporate investor, holding 2.02M shares valued at $38.16M. A 1.59% stake in Arcutis Biotherapeutics, Inc. is owned by the company. DRIEHAUS CAPITAL MANAGEMENT LLC owns 1.1M shares valued at $20.68M, which translates its holding of 0.86% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	PERPETUAL LTD	1.59%	2.02M	38.16M	2M	+7,534.26%
Sep 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.86%	1.1M	20.68M	11.05K	+1.02%
Sep 30, 2025	D. E. SHAW & CO., INC.	1.67%	2.12M	39.94M	-44.29K	-2.05%
Sep 30, 2025	PIVOTAL BIOVENTURE PARTNERS INVESTMENT ADVISOR LLC	1.67%	2.12M	39.97M	0	0
Sep 30, 2025	FRANKLIN RESOURCES INC	1.82%	2.31M	43.56M	-421.76K	-15.43%
Sep 30, 2025	JANUS HENDERSON GROUP PLC	1.89%	2.4M	45.18M	134.07K	+5.92%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.05%	2.61M	49.14M	23.9K	+0.93%
Sep 30, 2025	UBS GROUP AG	2.32%	2.95M	55.58M	10.5K	+0.36%
Sep 30, 2025	MORGAN STANLEY	3.37%	4.28M	80.61M	-38.14K	-0.88%
Sep 30, 2025	GILDER GAGNON HOWE & CO LLC	3.49%	4.43M	83.49M	273.35K	+6.58%
Sep 30, 2025	POLAR CAPITAL HOLDINGS PLC	4.17%	5.3M	99.88M	292.28K	+5.84%
Sep 30, 2025	BLACKROCK, INC.	6.75%	8.57M	161.62M	41.23K	+0.48%
Sep 30, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	7.78%	9.87M	186.13M	0	0
Sep 30, 2025	SUVRETTA CAPITAL MANAGEMENT, LLC	8.25%	10.48M	197.51M	-1.06M	-9.17%
Sep 30, 2025	RUBRIC CAPITAL MANAGEMENT LP	8.46%	10.75M	202.63M	0	0
Sep 30, 2025	AVIDITY PARTNERS MANAGEMENT LP	0.17%	214.4K	4.04M	-53.6K	-20.00%
Sep 30, 2025	ALGERT GLOBAL LLC	0.18%	229.39K	4.32M	130.64K	+132.28%
Sep 30, 2025	ALLY BRIDGE GROUP (NY) LLC	0.18%	233.22K	4.4M	233.22K	+100.00%
Sep 30, 2025	TEJARA CAPITAL LTD	0.41%	520.5K	9.81M	-352.88K	-40.40%
Sep 30, 2025	FISHMAN JAY A LTD/MI	0.45%	565.65K	10.66M	565.65K	+100.00%
Sep 30, 2025	JUPITER ASSET MANAGEMENT LTD	0.52%	659.33K	12.43M	246.59K	+59.75%
Sep 30, 2025	CANDRIAM S.C.A.	0.61%	778.04K	14.67M	-12.39K	-1.57%
Sep 30, 2025	STATE STREET CORP	3.65%	4.64M	87.49M	114.38K	+2.53%
Sep 30, 2025	VANGUARD GROUP INC	5.63%	7.15M	134.7M	96.99K	+1.38%
Sep 30, 2025	LAZARD ASSET MANAGEMENT LLC	0.22%	279.62K	5.27M	-106.39K	-27.56%
Sep 30, 2025	JENNISON ASSOCIATES LLC	9.65%	12.25M	230.99M	1.14M	+10.30%
Sep 30, 2025	PRIVIUM FUND MANAGEMENT B.V.	0.24%	305.97K	5.77M	-38.5K	-11.18%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.24%	310.62K	5.86M	5.36K	+1.76%
Sep 30, 2025	WOODLINE PARTNERS LP	0.25%	314.62K	5.93M	109.11K	+53.09%
Sep 30, 2025	SIMPLIFY ASSET MANAGEMENT INC.	0.25%	318K	5.99M	-91.44K	-22.33%
Sep 30, 2025	J. GOLDMAN & CO LP	0.28%	353.64K	6.67M	-506.62K	-58.89%
Sep 30, 2025	JANE STREET GROUP, LLC	0.28%	360.77K	6.8M	233.65K	+183.80%
Sep 30, 2025	DEUTSCHE BANK AG\	0.3%	377.53K	7.12M	10.11K	+2.75%
Sep 30, 2025	STEMPOINT CAPITAL LP	0.32%	411.89K	7.76M	206.22K	+100.27%
Sep 30, 2025	ABRDN PLC	0.53%	675.03K	12.72M	0	0
Sep 30, 2025	JUMP FINANCIAL, LLC	0.28%	350.49K	6.61M	335.92K	+2,306.85%
Sep 30, 2025	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.66%	833.49K	15.71M	833.49K	+100.00%
Sep 30, 2025	GW&K INVESTMENT MANAGEMENT, LLC	0.92%	1.17M	22.09M	-206.39K	-14.97%
Sep 30, 2025	NUVEEN, LLC	1.08%	1.37M	25.83M	604.78K	+79.00%
Sep 30, 2025	LEGATO CAPITAL MANAGEMENT LLC	0.04%	56.72K	1.07M	0	0
Sep 30, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.05%	63.03K	1.19M	32.16K	+104.21%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.05%	64.49K	1.22M	0	0
Sep 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.05%	66.04K	1.24M	34.18K	+107.27%
Sep 30, 2025	WESBANCO BANK INC	0.06%	71.7K	1.35M	-31K	-30.19%
Sep 30, 2025	ERSTE ASSET MANAGEMENT GMBH	0.06%	73.1K	1.36M	0	0
Sep 30, 2025	STIFEL FINANCIAL CORP	0.06%	79.81K	1.5M	-10.39K	-11.52%
Sep 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.07%	86.49K	1.63M	86.49K	+100.00%
Sep 30, 2025	AMI ASSET MANAGEMENT CORP	0.08%	96.09K	1.81M	-17.79K	-15.62%
Sep 30, 2025	JPMORGAN CHASE & CO	0.08%	100.79K	1.9M	-448K	-81.63%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.08%	105.26K	1.98M	-91.04K	-46.38%
Sep 30, 2025	PHOCAS FINANCIAL CORP.	0.08%	106.31K	2M	2.29K	+2.20%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.09%	109.44K	2.06M	-2.16K	-1.93%
Sep 30, 2025	LPL FINANCIAL LLC	0.09%	116.92K	2.2M	-4.69K	-3.86%
Sep 30, 2025	JACKSON CREEK INVESTMENT ADVISORS LLC	0.11%	135.82K	2.56M	-52	-0.04%
Sep 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.11%	140K	1.45M	0	0
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.12%	148.3K	2.8M	-6.06K	-3.92%
Sep 30, 2025	FMR LLC	0.13%	167.97K	3.17M	17.24K	+11.44%
Sep 30, 2025	RHUMBLINE ADVISERS	0.14%	183.13K	3.45M	-2.97K	-1.60%
Sep 30, 2025	INVESCO LTD.	0.15%	192.95K	3.64M	93.25K	+93.53%
Sep 30, 2025	ESSEX INVESTMENT MANAGEMENT CO LLC	0.15%	196.26K	3.7M	6.75K	+3.56%
Sep 30, 2025	SWISS NATIONAL BANK	0.16%	207.9K	3.92M	3.9K	+1.91%
Sep 30, 2025	FIRST TRUST ADVISORS LP	0.18%	224.97K	4.24M	-116.56K	-34.13%
Sep 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.35%	441.32K	8.32M	66.08K	+17.61%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.7%	889.29K	16.76M	-313.23K	-26.05%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	1.31%	1.66M	31.34M	-61.84K	-3.59%
Sep 30, 2025	ENSIGN PEAK ADVISORS, INC	1.57%	1.99M	37.57M	-8.38K	-0.42%
Sep 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.19%	244.02K	4.6M	-160.72K	-39.71%
Sep 30, 2025	BARCLAYS PLC	0.26%	325.97K	6.14M	-68.07K	-17.28%
Sep 30, 2025	PFM HEALTH SCIENCES, LP	0.28%	360.46K	6.79M	-562.92K	-60.96%
Sep 30, 2025	MYDA ADVISORS LLC	0.37%	470K	8.86M	100K	+27.03%
Sep 30, 2025	FEDERATED HERMES, INC.	0.6%	759.57K	14.32M	22.2K	+3.01%
Sep 30, 2025	CORMORANT ASSET MANAGEMENT, LP	0.61%	775K	14.61M	-225K	-22.50%
Sep 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.64%	814.57K	15.35M	237.07K	+41.05%
Sep 30, 2025	NORTHERN TRUST CORP	0.74%	940.2K	17.72M	11.51K	+1.24%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.79%	999.43K	18.84M	34.37K	+3.56%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.42%	1.8M	34.02M	-85.26K	-4.51%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	1.49%	1.89M	26.5M	786.83K	+71.31%
Jun 30, 2025	WOODLINE PARTNERS LP	0.16%	205.51K	2.88M	-204.49K	-49.88%
Jun 30, 2025	VANGUARD GROUP INC	5.55%	7.05M	98.83M	231.02K	+3.39%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.72%	910.84K	12.77M	437.22K	+92.31%
Jun 30, 2025	UBS ASSET MANAGEMENT AMERICAS INC	0.32%	404.74K	5.67M	125.69K	+45.04%
Jun 30, 2025	BARCLAYS PLC	0.31%	394.04K	5.53M	199.27K	+102.31%
Jun 30, 2025	STATE STREET CORP	3.56%	4.53M	63.47M	52.73K	+1.18%
Jun 30, 2025	MORGAN STANLEY	3.4%	4.31M	60.49M	475.99K	+12.40%
Jun 30, 2025	GILDER GAGNON HOWE & CO LLC	3.27%	4.16M	58.26M	59.71K	+1.46%
Jun 30, 2025	FRANKLIN RESOURCES INC	2.15%	2.73M	38.31M	-28.99K	-1.05%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.03%	2.58M	36.21M	35.62K	+1.40%
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	1.17%	1.49M	20.83M	654.95K	+78.86%
Jun 30, 2025	GW&K INVESTMENT MANAGEMENT, LLC	1.09%	1.38M	19.33M	-133.78K	-8.85%
Jun 30, 2025	DEUTSCHE BANK AG\	0.29%	367.42K	5.15M	-13.94K	-3.66%
Jun 30, 2025	CITIGROUP INC	0.28%	359.42K	5.04M	57.87K	+19.19%
Jun 30, 2025	PIVOTAL BIOVENTURE PARTNERS INVESTMENT ADVISOR LLC	1.67%	2.12M	29.73M	0	0
Jun 30, 2025	ENSIGN PEAK ADVISORS, INC	1.58%	2M	28.06M	13.05K	+0.66%
Jun 30, 2025	SUVRETTA CAPITAL MANAGEMENT, LLC	9.08%	11.54M	161.73M	112.6K	+0.99%
Jun 30, 2025	JENNISON ASSOCIATES LLC	8.75%	11.11M	155.75M	-251.47K	-2.21%
Jun 30, 2025	GRAHAM CAPITAL MANAGEMENT, L.P.	0.06%	71.62K	1M	34K	+90.39%
Jun 30, 2025	D. E. SHAW & CO., INC.	1.7%	2.16M	30.33M	173.49K	+8.72%
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	1.36%	1.72M	24.17M	71.82K	+4.35%
Jun 30, 2025	AVIDITY PARTNERS MANAGEMENT LP	0.21%	268K	3.76M	268K	+100.00%
Jun 30, 2025	ROYAL BANK OF CANADA	0.21%	263.81K	3.7M	259.14K	+5,552.65%
Jun 30, 2025	STEMPOINT CAPITAL LP	0.16%	205.67K	2.88M	-234.4K	-53.26%
Jun 30, 2025	STATE OF WISCONSIN INVESTMENT BOARD	0.07%	89.88K	1.26M	-62.98K	-41.20%
Jun 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.07%	86.28K	1.21M	16.59K	+23.80%
Jun 30, 2025	BLACKROCK, INC.	6.72%	8.53M	119.63M	-359.58K	-4.04%
Jun 30, 2025	READYSTATE ASSET MANAGEMENT LP	0.16%	200.25K	2.81M	140.05K	+232.65%
Jun 30, 2025	PDT PARTNERS, LLC	0.15%	190.98K	2.68M	-126.48K	-39.84%
Jun 30, 2025	ESSEX INVESTMENT MANAGEMENT CO LLC	0.15%	189.51K	2.66M	-1.13K	-0.59%
Jun 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.12%	154.35K	2.16M	-6.02K	-3.75%
Jun 30, 2025	FMR LLC	0.12%	150.73K	2.11B	-11.72K	-7.21%
Jun 30, 2025	DEKABANK DEUTSCHE GIROZENTRALE	0.11%	140K	1.46M	0	0
Jun 30, 2025	JACKSON CREEK INVESTMENT ADVISORS LLC	0.11%	135.87K	1.91M	22.34K	+19.67%
Jun 30, 2025	AMI ASSET MANAGEMENT CORP	0.09%	113.88K	1.6M	-94.84K	-45.44%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.09%	113.36K	1.59B	0	0
Jun 30, 2025	PHOCAS FINANCIAL CORP.	0.08%	104.01K	1.46M	15	+0.01%
Jun 30, 2025	WESBANCO BANK INC	0.08%	102.7K	1.44M	0	0
Jun 30, 2025	ALGERT GLOBAL LLC	0.08%	98.76K	1.39M	-22.13K	-18.30%
Jun 30, 2025	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	0.08%	97.68K	1.37B	0	0
Jun 30, 2025	ENGINEERS GATE MANAGER LP	0.08%	97.61K	1.37M	31.48K	+47.61%
Jun 30, 2025	VESTAL POINT CAPITAL, LP	0.07%	95K	1.33M	95K	+100.00%
Jun 30, 2025	RUBRIC CAPITAL MANAGEMENT LP	8.46%	10.75M	150.71M	-217.22K	-1.98%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.95%	1.2M	16.86M	687.56K	+133.52%
Jun 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.86%	1.09M	15.23M	-6.78K	-0.62%
Jun 30, 2025	CORMORANT ASSET MANAGEMENT, LP	0.79%	1M	14.02M	-350K	-25.93%
Jun 30, 2025	NORTHERN TRUST CORP	0.73%	928.69K	13.02M	-47.38K	-4.85%
Jun 30, 2025	PFM HEALTH SCIENCES, LP	0.73%	923.38K	12.95M	923.38K	+100.00%
Jun 30, 2025	TEJARA CAPITAL LTD	0.69%	873.38K	12.24M	27.16K	+3.21%
Jun 30, 2025	J. GOLDMAN & CO LP	0.68%	860.26K	12.06M	679.74K	+376.54%
Jun 30, 2025	CANDRIAM S.C.A.	0.62%	790.44K	11.08M	-245.14K	-23.67%
Jun 30, 2025		0.6%	765.58K	10.73M	-50.24K	-6.16%
Jun 30, 2025	FEDERATED HERMES, INC.	0.58%	737.37K	10.34M	-186	-0.03%
Jun 30, 2025	ABRDN PLC	0.53%	675.03K	9.46M	87.49K	+14.89%
Jun 30, 2025	PRUDENTIAL FINANCIAL INC	0.47%	598.9K	8.4M	5.71K	+0.96%
Jun 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.45%	577.49K	8.1M	385.27K	+200.43%
Jun 30, 2025	JPMORGAN CHASE & CO	0.43%	548.79K	7.69M	5.41K	+1.00%
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.41%	520.28K	7.29M	501.82K	+2,717.52%
Jun 30, 2025	JUPITER ASSET MANAGEMENT LTD	0.33%	412.74K	5.79M	412.74K	+100.00%
Jun 30, 2025	SIMPLIFY ASSET MANAGEMENT INC.	0.32%	409.43K	5.74M	-251.13K	-38.02%
Jun 30, 2025	LAZARD ASSET MANAGEMENT LLC	0.3%	386.01K	5.41M	11.93K	+3.19%
Jun 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.3%	375.23K	5.26M	127.04K	+51.18%
Jun 30, 2025	PRIVIUM FUND MANAGEMENT B.V.	0.27%	344.47K	4.74M	18.76K	+5.76%
Jun 30, 2025	FIRST TRUST ADVISORS LP	0.27%	341.52K	4.79M	-98.66K	-22.41%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.76%	965.07K	13.53M	104.3K	+12.12%
Jun 30, 2025	NUVEEN, LLC	0.6%	765.58K	10.73M	-50.24K	-6.16%
Jun 30, 2025	ROYCE & ASSOCIATES LP	0.29%	374.54K	5.25M	106.93K	+39.96%
Jun 30, 2025	MYDA ADVISORS LLC	0.29%	370K	5.19M	80K	+27.59%
Jun 30, 2025	UBS GROUP AG	2.31%	2.94M	41.19M	17.93K	+0.61%
Jun 30, 2025	JANUS HENDERSON GROUP PLC	1.78%	2.26M	31.76M	2.21M	+4,204.11%
Jun 30, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	7.78%	9.87M	138.44M	1.09M	+12.40%
Jun 30, 2025	POLAR CAPITAL HOLDINGS PLC	3.94%	5.01M	70.19M	-1.7M	-25.35%
Mar 31, 2025	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	6.97%	8.79M	137.4M	0	0
Mar 31, 2025	VANGUARD GROUP INC	5.41%	6.82M	106.63M	377.36K	+5.86%
Mar 31, 2025	POLAR CAPITAL HOLDINGS PLC	5.32%	6.71M	104.89M	-670.91K	-9.09%
Mar 31, 2025	STATE STREET CORP	3.55%	4.47M	69.98M	-476.52K	-9.63%
Mar 31, 2025	GILDER GAGNON HOWE & CO LLC	3.25%	4.1M	64.06M	193.06K	+4.95%
Mar 31, 2025	UBS GROUP AG	2.32%	2.92M	45.67M	130.48K	+4.68%
Mar 31, 2025	NORTHERN TRUST CORP	0.77%	976.07K	15.27M	-14.99K	-1.51%
Mar 31, 2025	FEDERATED HERMES, INC.	0.59%	737.56K	11.54M	244.63K	+49.63%
Mar 31, 2025	SIMPLIFY ASSET MANAGEMENT INC.	0.52%	660.56K	10.33M	-81.74K	-11.01%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.41%	514.95K	8.05M	-21.51K	-4.01%
Mar 31, 2025	FRANKLIN RESOURCES INC	2.19%	2.76M	43.19M	-547.55K	-16.55%
Mar 31, 2025	ABRDN PLC	0.47%	587.54K	9.19M	105.47K	+21.88%
Mar 31, 2025	JPMORGAN CHASE & CO	0.43%	543.38K	8.5M	-598.12K	-52.40%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.38%	473.63K	7.41M	-1.84M	-79.50%
Mar 31, 2025	AMERICAN CENTURY COMPANIES INC	1.31%	1.65M	25.84M	21.27K	+1.30%
Mar 31, 2025	PIVOTAL BIOVENTURE PARTNERS INVESTMENT ADVISOR LLC	1.68%	2.12M	33.16M	0	0
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	2.02%	2.55M	39.84M	74.22K	+3.00%
Mar 31, 2025	MORGAN STANLEY	3.05%	3.84M	60.03M	-405.37K	-9.55%
Mar 31, 2025	RUBRIC CAPITAL MANAGEMENT LP	8.7%	10.97M	171.52M	0	0
Mar 31, 2025	CITIGROUP INC	0.24%	301.55K	4.72M	-25.71K	-7.86%
Mar 31, 2025	CITADEL ADVISORS LLC	0.25%	310.08K	4.85M	220.91K	+247.74%
Mar 31, 2025	WOODLINE PARTNERS LP	0.33%	410K	6.41M	410K	+100.00%
Mar 31, 2025	CORMORANT ASSET MANAGEMENT, LP	1.07%	1.35M	21.11M	-475K	-26.03%
Mar 31, 2025	GW&K INVESTMENT MANAGEMENT, LLC	1.2%	1.51M	23.65M	-31.87K	-2.06%
Mar 31, 2025	PARADIGM BIOCAPITAL ADVISORS LP	1.16%	1.47M	22.92M	1.47M	+100.00%
Mar 31, 2025	BLACKROCK, INC.	7.06%	8.89M	139.08M	-256.22K	-2.80%
Mar 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.87%	1.09M	17.09M	-4.03K	-0.37%
Mar 31, 2025	CANDRIAM S.C.A.	0.82%	1.04M	16.2M	-6.57K	-0.63%
Mar 31, 2025	CERCANO MANAGEMENT LLC	0.74%	928.7K	14.52M	-326.66K	-26.02%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.68%	860.77K	13.46M	-18.04K	-2.05%
Mar 31, 2025	FISHMAN JAY A LTD/MI	0.42%	533.15K	8.34M	-3.25K	-0.61%
Mar 31, 2025	SUVRETTA CAPITAL MANAGEMENT, LLC	9.06%	11.42M	178.66M	23.84K	+0.21%
Mar 31, 2025	PDT PARTNERS, LLC	0.25%	317.47K	4.97M	-2.25K	-0.70%
Mar 31, 2025	PRIVIUM FUND MANAGEMENT B.V.	0.26%	325.71K	5.09M	0	0
Mar 31, 2025	LAZARD ASSET MANAGEMENT LLC	0.3%	374.08K	5.85M	-14.23K	-3.66%
Mar 31, 2025	DEUTSCHE BANK AG\	0.3%	381.36K	5.96M	-6.18K	-1.59%
Mar 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.34%	427.43K	6.69M	324.29K	+314.42%
Mar 31, 2025	STEMPOINT CAPITAL LP	0.35%	440.07K	6.88M	-60.89K	-12.16%
Mar 31, 2025	FIRST TRUST ADVISORS LP	0.35%	440.19K	6.88M	177.05K	+67.28%
Mar 31, 2025	PRUDENTIAL FINANCIAL INC	0.47%	593.2K	9.28M	630	+0.11%
Mar 31, 2025	ENSIGN PEAK ADVISORS, INC	1.58%	1.99M	31.1M	-385.75K	-16.25%
Mar 31, 2025	D. E. SHAW & CO., INC.	1.58%	1.99M	31.12M	-524.07K	-20.85%
Mar 31, 2025		0.65%	815.82K	12.76M	815.82K	+100.00%
Mar 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.66%	830.48K	12.99M	-923.04K	-52.64%
Mar 31, 2025	TEJARA CAPITAL LTD	0.67%	846.22K	13.23M	-40.62K	-4.58%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.88%	1.1M	17.26M	-202.75K	-15.52%
Mar 31, 2025	INVESCO LTD.	1.05%	1.33M	20.78M	202.29K	+17.95%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.23%	292.1K	4.57M	50.6K	+20.95%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.24%	300.03K	4.69M	-4.98K	-1.63%
Mar 31, 2025	JENNISON ASSOCIATES LLC	9.01%	11.36M	177.68M	-978.92K	-7.93%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	1.08%	750.72K	7.44M	179.41K	+31.40%
Mar 31, 2024	NORTHERN TRUST CORP	1.08%	748.95K	7.42M	18.2K	+2.49%
Mar 31, 2024	PRUDENTIAL FINANCIAL INC	1.04%	723.33K	7.17M	-94.73K	-11.58%
Mar 31, 2024	CITIGROUP INC	1.03%	716.44K	7.1M	703.73K	+5,535.49%
Mar 31, 2024	SIO CAPITAL MANAGEMENT, LLC	0.92%	635.97K	6.3M	0	0
Mar 31, 2024	IKARIAN CAPITAL, LLC	0.85%	589.64K	5.84M	589.64K	+100.00%
Mar 31, 2024	HSBC HOLDINGS PLC	0.73%	506.29K	5.01M	362.35K	+251.75%
Mar 31, 2024	ECOR1 CAPITAL, LLC	0.72%	500K	4.96M	500K	+100.00%
Mar 31, 2024	UBS GROUP AG	0.71%	490.68K	4.86M	488.58K	+23,265.57%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.7%	484.08K	4.8M	-494.72K	-50.54%
Mar 31, 2024	TRI LOCUM PARTNERS LP	0.65%	449.69K	4.46M	449.69K	+100.00%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.6%	412.7K	4.09M	398.4K	+2,786.01%
Mar 31, 2024	MONASHEE INVESTMENT MANAGEMENT LLC	0.55%	380K	3.77M	380K	+100.00%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	0.55%	379.05K	3.76M	-2.18M	-85.19%
Mar 31, 2024	CAPTION MANAGEMENT, LLC	0.54%	373.4K	3.7M	373.4K	+100.00%
Mar 31, 2024	JENNISON ASSOCIATES LLC	17.57%	12.18M	120.67M	3.11M	+34.31%
Mar 31, 2024	RUBRIC CAPITAL MANAGEMENT LP	10.84%	7.51M	74.42M	865.47K	+13.03%
Mar 31, 2024	BLACKROCK INC.	9.61%	6.66M	65.99M	742.2K	+12.54%
Mar 31, 2024	PIVOTAL BIOVENTURE PARTNERS INVESTMENT ADVISOR LLC	2.93%	2.03M	20.1M	118K	+6.18%
Mar 31, 2024	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	2.9%	2.01M	19.94M	-988.31K	-32.94%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	2.84%	1.97M	19.54M	227.84K	+13.07%
Mar 31, 2024	STEMPOINT CAPITAL LP	1.19%	825K	515.63K	825K	+100.00%
Mar 31, 2024	RAFFERTY ASSET MANAGEMENT, LLC	1.19%	822.46K	8.15M	822.46K	+100.00%
Mar 31, 2024	TWO SEAS CAPITAL LP	1.17%	809.33K	8.02M	809.33K	+100.00%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	1.16%	806.52K	7.99M	73.52K	+10.03%
Mar 31, 2024	TREXQUANT INVESTMENT LP	0.52%	362.87K	3.6M	362.87K	+100.00%
Mar 31, 2024	FEDERATED HERMES, INC.	0.51%	350.11K	3.47M	-171.36K	-32.86%
Mar 31, 2024	AMI ASSET MANAGEMENT CORP	0.5%	345.24K	3.42M	345.24K	+100.00%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.45%	310.12K	3.07M	-7.8K	-2.45%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.36%	248.19K	2.46M	34.35K	+16.06%
Mar 31, 2024	FISHMAN JAY A LTD/MI	0.32%	224.3K	2.22M	171.3K	+323.21%
Mar 31, 2024	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.32%	222.22K	2.2M	222.22K	+100.00%
Mar 31, 2024	LPL FINANCIAL LLC	0.23%	158.21K	1.57M	-31.44K	-16.58%
Mar 31, 2024	ABRDN PLC	0.21%	148.87K	1.48M	0	0
Mar 31, 2024	LOS ANGELES CAPITAL MANAGEMENT LLC	0.21%	148.43K	1.47M	-46.03K	-23.67%
Mar 31, 2024	FMR LLC	0.2%	141.1K	1.4M	-1.08M	-88.46%
Mar 31, 2024	DEKABANK DEUTSCHE GIROZENTRALE	0.2%	140K	1.34M	0	0
Mar 31, 2024	PROFUND ADVISORS LLC	0.18%	126.28K	1.25B	126.28K	+100.00%
Mar 31, 2024	RHUMBLINE ADVISERS	0.18%	125.33K	1.24M	18.4K	+17.21%
Mar 31, 2024	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.17%	120.49K	1.19M	120.49K	+100.00%
Mar 31, 2024	CAPULA MANAGEMENT LTD	0.12%	79.97K	792.48K	79.97K	+100.00%
Mar 31, 2024	MYDA ADVISORS LLC	0.11%	75K	743.25K	-145K	-65.91%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.11%	74.7K	740.28K	7.44K	+11.06%
Mar 31, 2024	JUMP FINANCIAL, LLC	0.1%	67.6K	669.9K	67.6K	+100.00%
Mar 31, 2024	GROUP ONE TRADING, L.P.	0.09%	60.35K	598.04K	8.66K	+16.76%
Mar 31, 2024	CAPSTONE INVESTMENT ADVISORS, LLC	0.08%	57.38K	568.62K	57.38K	+100.00%
Mar 31, 2024	HENNION & WALSH ASSET MANAGEMENT, INC.	0.07%	49K	485.56K	6.16K	+14.37%
Mar 31, 2024	MIRAE ASSET GLOBAL INVESTMENTS CO., LTD.	0.07%	46.65K	468.59K	46.65K	+100.00%
Mar 31, 2024	METLIFE INVESTMENT MANAGEMENT, LLC	0.06%	43.8K	434.07K	0	0
Mar 31, 2024	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	12.68%	8.79M	87.06M	21.05K	+0.24%
Mar 31, 2024	STATE STREET CORP	12.67%	8.78M	87.05M	7.26M	+475.99%
Mar 31, 2024	SUVRETTA CAPITAL MANAGEMENT, LLC	11.37%	7.88M	78.06M	-595.8K	-7.03%
Mar 31, 2024	POLAR CAPITAL HOLDINGS PLC	9.94%	6.89M	68.24M	588.23K	+9.34%
Mar 31, 2024	VANGUARD GROUP INC	7.45%	5.17M	51.2M	269.9K	+5.51%
Mar 31, 2024	FRANKLIN RESOURCES INC	6.7%	4.64M	46.01M	-13.08K	-0.28%
Mar 31, 2024	GILDER GAGNON HOWE & CO LLC	6.11%	4.23M	41.97M	4.23M	+100.00%
Mar 31, 2024	MORGAN STANLEY	5.78%	4.01M	39.7M	-2.08M	-34.14%
Mar 31, 2024	ENSIGN PEAK ADVISORS, INC	4.3%	2.98M	29.54M	950.39K	+46.82%
Mar 31, 2024	CORMORANT ASSET MANAGEMENT, LP	3.07%	2.13M	21.06M	2.13M	+100.00%
Mar 31, 2024	CITADEL ADVISORS LLC	2.76%	1.91M	18.97M	1.91M	+100.00%
Mar 31, 2024	DEUTSCHE BANK AG\	2.7%	1.87M	18.56M	478.2K	+34.29%
Mar 31, 2024	FARALLON CAPITAL MANAGEMENT LLC	2.57%	1.78M	17.64M	1.78M	+100.00%
Mar 31, 2024	GW&K INVESTMENT MANAGEMENT, LLC	2.48%	1.72M	17.06M	80.93K	+4.93%
Mar 31, 2024	J. GOLDMAN & CO LP	2.07%	1.44M	14.22M	1.27M	+755.72%
Mar 31, 2024	BRAIDWELL LP	1.88%	1.3M	12.88M	1.3M	+100.00%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	1.5%	1.04M	10.32M	129.14K	+14.16%
Mar 31, 2024	JPMORGAN CHASE & CO	1.44%	1M	9.91M	928.74K	+1,299.57%
Mar 31, 2024	VOLORIDGE INVESTMENT MANAGEMENT, LLC	1.36%	943.47K	9.35M	943.47K	+100.00%
Mar 31, 2024	TEJARA CAPITAL LTD	1.36%	940.49K	9.32M	-171.73K	-15.44%
Mar 31, 2024	INVESCO LTD.	1.26%	872.34K	8.64M	847.21K	+3,370.50%
Mar 31, 2024	BANK OF AMERICA CORP /DE/	1.23%	850.53K	8.43M	759.51K	+834.46%
Mar 31, 2024	BALYASNY ASSET MANAGEMENT L.P.	1.13%	780.78K	7.74M	780.78K	+100.00%
Mar 31, 2024	PERCEPTIVE ADVISORS LLC	1.08%	750K	7.43M	750K	+100.00%
Dec 31, 2023	MORGAN STANLEY	9.85%	6.08M	19.65M	5.86M	+2,639.63%
Dec 31, 2023	BLACKROCK INC.	9.59%	5.92M	19.11M	1.9M	+47.16%
Dec 31, 2023	OPALEYE MANAGEMENT INC.	3.18%	1.96M	6.33M	1.96M	+100.00%
Dec 31, 2023	VANGUARD GROUP INC	7.93%	4.9M	15.82M	2.02M	+70.05%
Dec 31, 2023	FRANKLIN RESOURCES INC	7.54%	4.66M	15.04M	3.36M	+260.24%
Dec 31, 2023	POLAR CAPITAL HOLDINGS PLC	10.2%	6.3M	20.34M	3.18M	+101.98%
Dec 31, 2023	RUBRIC CAPITAL MANAGEMENT LP	10.76%	6.64M	21.46M	1.61M	+31.98%
Dec 31, 2023	SIO CAPITAL MANAGEMENT, LLC	1.03%	635.97K	2.05M	0	0
Dec 31, 2023	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	4.86%	3M	9.69M	0	0
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	4.15%	2.56M	8.27M	2.25M	+728.25%
Dec 31, 2023	ENSIGN PEAK ADVISORS, INC	3.29%	2.03M	6.56M	1.2M	+145.73%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.93%	571.32K	1.85M	187.51K	+48.85%
Dec 31, 2023	FEDERATED HERMES, INC.	0.84%	521.47K	1.68M	461.47K	+769.12%
Dec 31, 2023	PIVOTAL BIOVENTURE PARTNERS INVESTMENT ADVISOR LLC	3.09%	1.91M	6.17M	804.7K	+72.80%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	2.82%	1.74M	5.63M	705.64K	+67.98%
Dec 31, 2023	GW&K INVESTMENT MANAGEMENT, LLC	2.66%	1.64M	5.3M	-428.97K	-20.73%
Dec 31, 2023	RENAISSANCE TECHNOLOGIES LLC	0.64%	395.1K	1.28M	395.1K	+100.00%
Dec 31, 2023	ACADIAN ASSET MANAGEMENT LLC	0.57%	354.11K	1.14M	354.11K	+100.00%
Dec 31, 2023	WALLEYE CAPITAL LLC	0.52%	323.6K	1.05M	323.6K	+100.00%
Dec 31, 2023	POINT72 ASSET MANAGEMENT, L.P.	0.52%	320.3K	1.03M	320.3K	+100.00%
Dec 31, 2023	STATE STREET CORP	2.47%	1.53M	4.93M	-2.84M	-65.03%
Dec 31, 2023	DEUTSCHE BANK AG\	2.26%	1.39M	4.5M	1.36M	+4,492.62%
Dec 31, 2023	FMR LLC	1.98%	1.22M	3.95M	-7.04M	-85.20%
Dec 31, 2023	TEJARA CAPITAL LTD	1.8%	1.11M	3.59M	803.04K	+259.73%
Dec 31, 2023	AMERIPRISE FINANCIAL INC	1.75%	1.08M	3.49M	1.08M	+100.00%
Dec 31, 2023	TWO SIGMA INVESTMENTS, LP	1.59%	978.81K	3.16M	978.81K	+100.00%
Dec 31, 2023	AMERICAN CENTURY COMPANIES INC	1.48%	911.8K	2.95M	401.71K	+78.75%
Dec 31, 2023	PRUDENTIAL FINANCIAL INC	1.33%	818.06K	2.64M	454.64K	+125.10%
Dec 31, 2023	GOLDMAN SACHS GROUP INC	1.19%	733K	2.37M	399.99K	+120.11%
Dec 31, 2023	SUVRETTA CAPITAL MANAGEMENT, LLC	13.73%	8.47M	27.37M	7.34M	+646.38%
Dec 31, 2023	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	14.2%	8.76M	28.31M	80K	+0.92%
Dec 31, 2023	JENNISON ASSOCIATES LLC	14.69%	9.07M	29.28M	4.63M	+104.55%
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.52%	317.93K	1.03M	80.15K	+33.71%
Dec 31, 2023	AQR CAPITAL MANAGEMENT LLC	0.47%	289.09K	933.75K	289.09K	+100.00%
Dec 31, 2023	PARALLAX VOLATILITY ADVISERS, L.P.	0.45%	275.26K	889.1K	-7.17K	-2.54%
Dec 31, 2023		0.45%	275K	888.25K	275K	+100.00%
Dec 31, 2023	MYDA ADVISORS LLC	0.36%	220K	710.6K	220K	+100.00%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.35%	213.84K	690.69K	-5.34K	-2.44%
Dec 31, 2023	LOS ANGELES CAPITAL MANAGEMENT LLC	0.32%	194.46K	628.11K	194.46K	+100.00%
Dec 31, 2023	LPL FINANCIAL LLC	0.31%	189.64K	612.55K	106.13K	+127.08%
Dec 31, 2023	PENNANT INVESTORS, LP	0.28%	170.9K	552.01K	170.9K	+100.00%
Dec 31, 2023	WEISS MULTI-STRATEGY ADVISERS LLC	0.28%	170K	549K	96.04K	+129.84%
Dec 31, 2023	J. GOLDMAN & CO LP	0.27%	167.73K	541.78K	167.73K	+100.00%
Dec 31, 2023	JANE STREET GROUP, LLC	0.26%	160.6K	518.74K	37.58K	+30.54%
Dec 31, 2023	SQUAREPOINT OPS LLC	0.24%	149.42K	482.64K	90.57K	+153.87%
Dec 31, 2023	ABRDN PLC	0.24%	148.87K	480.86K	148.87K	+100.00%
Dec 31, 2023	QUBE RESEARCH & TECHNOLOGIES LTD	1.18%	725.89K	2.34M	725.89K	+100.00%
Dec 31, 2023	NORTHERN TRUST CORP	1.18%	730.74K	2.36M	247.25K	+51.14%
Sep 30, 2023	HENNION & WALSH ASSET MANAGEMENT, INC.	0.16%	95.31K	-	-7.11K	-6.94%
Sep 30, 2023	JANE STREET GROUP, LLC	0.2%	123.03K	-	-29.8K	-19.50%
Sep 30, 2023	SWISS NATIONAL BANK	0.16%	101.2K	-	9.1K	+9.88%
Sep 30, 2023	RUBRIC CAPITAL MANAGEMENT LP	8.2%	5.03M	-	150K	+3.07%
Sep 30, 2023	FMR LLC	13.45%	8.26M	-	-950.74K	-10.32%
Sep 30, 2023	DIMENSIONAL FUND ADVISORS LP	0.21%	127.28K	-	-15.32K	-10.74%
Sep 30, 2023	HSBC HOLDINGS PLC	0.23%	143.94K	-	-880	-0.61%
Sep 30, 2023	TWO SEAS CAPITAL LP	0.27%	164.81K	-	-67.39K	-29.02%
Sep 30, 2023	ALPHACENTRIC ADVISORS LLC	0.27%	165K	-	-127.5K	-43.59%
Sep 30, 2023	CITIGROUP INC	0.29%	176.82K	-	23.23K	+15.13%
Sep 30, 2023	PDT PARTNERS, LLC	0.32%	195.08K	-	74.5K	+61.79%
Sep 30, 2023	BARCLAYS PLC	0.34%	207.08K	-	-26.34K	-11.28%
Sep 30, 2023	CENTIVA CAPITAL, LP	0.34%	210K	-	120K	+133.33%
Sep 30, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.36%	219.18K	-	6.48K	+3.05%
Sep 30, 2023	MORGAN STANLEY	0.36%	222.04K	-	-263.94K	-54.31%
Sep 30, 2023	BANK OF NEW YORK MELLON CORP	0.39%	237.78K	-	27.17K	+12.90%
Sep 30, 2023	PARALLAX VOLATILITY ADVISERS, L.P.	0.46%	282.43K	-	22.58K	+8.69%
Sep 30, 2023	PERCEPTIVE ADVISORS LLC	0.49%	300K	-	0	0
Sep 30, 2023	TEJARA CAPITAL LTD	0.5%	309.18K	-	145K	+88.32%
Sep 30, 2023	GOLDMAN SACHS GROUP INC	0.54%	333.01K	-	-361.31K	-52.04%
Sep 30, 2023	PRUDENTIAL FINANCIAL INC	0.59%	363.42K	-	0	0
Sep 30, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.62%	383.81K	-	53.87K	+16.33%
Sep 30, 2023	RAFFERTY ASSET MANAGEMENT, LLC	0.68%	419.31K	-	-80.61K	-16.13%
Sep 30, 2023	NORTHERN TRUST CORP	0.79%	483.5K	-	17.85K	+3.83%
Sep 30, 2023	AMERICAN CENTURY COMPANIES INC	0.83%	510.09K	-	215	+0.04%
Sep 30, 2023	SIO CAPITAL MANAGEMENT, LLC	1.04%	635.97K	-	342.92K	+117.02%
Sep 30, 2023	ENSIGN PEAK ADVISORS, INC	1.34%	826.1K	-	-6.45K	-0.77%
Sep 30, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.69%	1.04M	-	100.5K	+10.72%
Sep 30, 2023	WOODLINE PARTNERS LP	1.8%	1.1M	-	296.49K	+36.71%
Sep 30, 2023	FRAZIER LIFE SCIENCES MANAGEMENT, L.P.	14.14%	8.68M	-	0	0
Sep 30, 2023	POLAR CAPITAL HOLDINGS PLC	5.08%	3.12M	-	-9.83K	-0.31%
Sep 30, 2023	GW&K INVESTMENT MANAGEMENT, LLC	3.37%	2.07M	-	6.61K	+0.32%
Sep 30, 2023	ORBIMED ADVISORS LLC	3.12%	1.91M	-	0	0
Sep 30, 2023	FRANKLIN RESOURCES INC	2.1%	1.29M	-	-360.18K	-21.80%
Sep 30, 2023	HOLOCENE ADVISORS, LP	1.96%	1.2M	-	-235.5K	-16.35%
Sep 30, 2023	PIVOTAL BIOVENTURE PARTNERS INVESTMENT ADVISOR LLC	1.8%	1.11M	-	0	0
Sep 30, 2023	PROFUND ADVISORS LLC	0.11%	69.93K	-	-19.85K	-22.11%
Sep 30, 2023	ALLIANCEBERNSTEIN L.P.	0.12%	72.36K	-	-7.67K	-9.58%
Sep 30, 2023	WEISS MULTI-STRATEGY ADVISERS LLC	0.12%	73.96K	-	-194.98K	-72.50%
Sep 30, 2023	DARK FOREST CAPITAL MANAGEMENT LP	0.12%	74.29K	-	74.29K	+100.00%
Sep 30, 2023	STATE OF WISCONSIN INVESTMENT BOARD	0.12%	75.46K	-	38.09K	+101.93%
Sep 30, 2023	RHUMBLINE ADVISERS	0.13%	79.43K	-	878	+1.12%
Sep 30, 2023	UBS ASSET MANAGEMENT AMERICAS INC	0.13%	81.08K	-	21.47K	+36.01%
Sep 30, 2023	LPL FINANCIAL LLC	0.14%	83.51K	-	48.93K	+141.49%
Sep 30, 2023	SYMMETRY INVESTMENTS LP	0.14%	85K	-	85K	+100.00%
Sep 30, 2023	CAPTION MANAGEMENT, LLC	0.14%	85K	-	0	0
Sep 30, 2023	WELLS FARGO & COMPANY/MN	0.14%	86.78K	-	-19.97K	-18.71%
Sep 30, 2023	BLACKROCK INC.	6.54%	4.02M	-	-210.97K	-4.99%
Sep 30, 2023	JENNISON ASSOCIATES LLC	7.21%	4.43M	-	138.21K	+3.22%
Sep 30, 2023	FISHMAN JAY A LTD/MI	0.14%	87K	-	10K	+12.99%

Insiders

Among the ARQT insiders holding of 1.68% of the stake in company, FRAZIER LIFE SCIENCES VIII, L.P., 10 percent owner, holds the largest shares of 8.76M. WATANABE TODD FRANKLIN, See Remarks, is the second largest ARQT insider with ownership of 913.8K shares. WATANABE TODD, See Remarks, stands third with possession of 721.31K shares of that stake.

Insiders	Designation	Shares Held
FRAZIER LIFE SCIENCES VIII, L.P.	10 percent owner	8.76M
WATANABE TODD FRANKLIN	See Remarks	913.8K
WATANABE TODD	See Remarks	721.31K
ORBIMED ADVISORS LLC	10 percent owner	415.14K
ORBIMED CAPITAL GP VII LLC		415.14K
OSBORNE DAVID W	Chief Technical Officer	268.85K
TOPPER DAVID JOSEPH	Chief Financial Officer	182.77K
MATSUDA MASARU	See Remarks	150.64K
EDWARDS LARRY TODD	See Remarks	148.87K
MOORE MATTHEW RICHARD	SVP and Chief Business Officer	145.51K
BURNETT PATRICK	See Remarks	80.65K
VAIRAVAN LATHA	SVP Chief Financial Officer	63.61K
LOCK KENNETH A.	Chief Commercial Officer	63.43K
TURNEY PATRICIA A.	SVP, Operations	62.86K
WELGUS HOWARD G.	director	59.74K
BURROWS SCOTT L	Chief Financial Officer	59.12K
HERON PATRICK J	director	27.45K
LIN SUE-JEAN	director	26.74K
KRISHNAMOHAN NEHA	director	22.12K
GILBERT HALLEY E	director	22.12K
CURRAN TERRIE	director	10.14K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Feb 04, 2026	BURNETT PATRICK	SALE	25.81	9.79K	252.75K	80.65K
Feb 02, 2026	BURNETT PATRICK	SALE	25.50	3.68K	93.71K	90.45K
Feb 02, 2026	EDWARDS LARRY TODD	SALE	25.50	2.05K	52.32K	148.87K
Feb 02, 2026	WATANABE TODD	SALE	25.50	19.83K	505.71K	721.31K
Feb 02, 2026	VAIRAVAN LATHA	SALE	25.50	1.32K	33.66K	63.61K
Feb 02, 2026	WELGUS HOWARD G.	SALE	25.05	10K	250.48K	59.74K
Jan 05, 2026	BURNETT PATRICK	SALE	28.98	2.49K	72.17K	94.12K
Jan 02, 2026	WELGUS HOWARD G.	SALE	28.96	10K	289.61K	69.74K
Dec 31, 2025	BURNETT PATRICK	SALE	29.39	1.16K	33.97K	96.61K
Dec 15, 2025	BURNETT PATRICK	SALE	28.94	11.5K	332.85K	98.31K
Dec 01, 2025	WELGUS HOWARD G.	SALE	30.21	10K	302.13K	79.74K
Dec 01, 2025	MATSUDA MASARU	SALE	30.23	1.66K	50.09K	150.64K
Nov 24, 2025	LIN SUE-JEAN	SALE	30.78	25.27K	777.96K	26.74K
Nov 24, 2025	WATANABE TODD	SALE	30.36	48.95K	1.49M	740.54K
Nov 21, 2025	WATANABE TODD	SALE	30.00	1.06K	31.65K	793.84K
Nov 20, 2025	GILBERT HALLEY E	SALE	27.55	16.53K	455.44K	22.12K
Nov 19, 2025	MATSUDA MASARU	SALE	28.50	1.56K	44.49K	151.48K
Nov 13, 2025	KRISHNAMOHAN NEHA	SALE	23.37	1.23K	28.79K	22.12K
Nov 06, 2025	BURNETT PATRICK	SALE	24.18	17.25K	417.14K	98.33K
Nov 06, 2025	EDWARDS LARRY TODD	SALE	25.16	29.13K	732.93K	150.19K
Nov 05, 2025	BURNETT PATRICK	SALE	23.72	3.86K	91.64K	98.33K
Nov 03, 2025	BURNETT PATRICK	SALE	25.40	15	381	102.19K
Nov 03, 2025	WATANABE TODD	SALE	25.40	69	1.75K	794.89K
Nov 03, 2025	VAIRAVAN LATHA	SALE	24.72	88	2.18K	64.93K
Nov 03, 2025	WELGUS HOWARD G.	SALE	25.27	10K	252.67K	89.74K
Nov 03, 2025	MATSUDA MASARU	SALE	25.40	43	1.09K	154.03K
Oct 28, 2025	WATANABE TODD	SALE	25.03	40K	1M	806.44K
Oct 02, 2025	WATANABE TODD	SALE	20.04	20.74K	415.57K	846.44K
Oct 02, 2025	EDWARDS LARRY TODD	SALE	19.99	4.21K	84.09K	178.9K
Oct 01, 2025	WELGUS HOWARD G.	SALE	18.92	462	8.74K	99.74K
Oct 01, 2025	WATANABE TODD	SALE	20.02	9.26K	185.37K	867.18K
Sep 09, 2025	WATANABE TODD	SALE	17.52	504	8.83K	891.44K
Sep 08, 2025	WATANABE TODD	SALE	17.54	9.63K	168.8K	891.94K
Sep 04, 2025	MATSUDA MASARU	SALE	16.16	36.13K	583.72K	161.23K
Sep 02, 2025	WELGUS HOWARD G.	SALE	15.64	10K	156.38K	100.21K
Aug 21, 2025	BURNETT PATRICK	SALE	15.57	2.44K	37.97K	104.81K
Aug 19, 2025	BURNETT PATRICK	SALE	16.16	1.75K	28.28K	107.25K
Aug 08, 2025	BURNETT PATRICK	SALE	14.03	3.85K	53.99K	109K
Aug 04, 2025	MATSUDA MASARU	SALE	14.33	6.33K	90.69K	197.36K
Aug 04, 2025	WATANABE TODD	SALE	14.33	11.55K	165.43K	901.57K
Aug 04, 2025	BURNETT PATRICK	SALE	14.33	2.62K	37.56K	112.85K
Aug 04, 2025	VAIRAVAN LATHA	SALE	14.33	89	1.28K	65.02K
Aug 01, 2025	WELGUS HOWARD G.	SALE	14.30	3.89K	55.62K	100.21K
Jul 14, 2025	BURNETT PATRICK	SALE	15.07	5.75K	86.65K	115.47K
Jul 10, 2025	BURNETT PATRICK	SALE	15.05	23K	346.05K	115.47K
Jul 01, 2025	WELGUS HOWARD G.	SALE	13.84	9.21K	127.43K	100.21K
Jun 18, 2025	WELGUS HOWARD G.	SALE	13.37	10.14K	135.57K	109.41K
Jun 13, 2025	HERON PATRICK J	PURCHASE	13.08	2.65K	34.61K	27.45K
Jun 05, 2025	HERON PATRICK J	PURCHASE	13.41	378	5.07K	24.8K
Jun 04, 2025	HERON PATRICK J	PURCHASE	13.32	1.89K	25.18K	24.42K
May 28, 2025	MATSUDA MASARU	SALE	13.78	1.8K	24.81K	202.6K
May 22, 2025	HERON PATRICK J	PURCHASE	13.65	2.52K	34.4K	22.53K
May 21, 2025	HERON PATRICK J	PURCHASE	13.66	2.52K	34.42K	20.01K
May 19, 2025	EDWARDS LARRY TODD	SALE	14.07	7.45K	104.85K	183.1K
May 15, 2025	HERON PATRICK J	PURCHASE	13.62	2.52K	34.32K	17.49K
May 14, 2025	HERON PATRICK J	PURCHASE	13.76	6.3K	86.69K	14.97K
May 13, 2025	HERON PATRICK J	PURCHASE	13.76	2.37K	32.66K	8.67K
May 09, 2025	HERON PATRICK J	PURCHASE	13.60	6.3K	85.69K	6.3K
May 08, 2025	BURNETT PATRICK	SALE	13.59	3.87K	52.62K	115.47K
May 02, 2025	MATSUDA MASARU	SALE	15.20	5.03K	76.45K	204.4K
May 02, 2025	BURNETT PATRICK	SALE	15.19	2.6K	39.44K	119.34K
May 02, 2025	WATANABE TODD FRANKLIN	SALE	15.19	11.45K	173.92K	913.8K
May 01, 2025	WELGUS HOWARD G.	SALE	14.64	10K	146.36K	111.94K
Apr 02, 2025	TOPPER DAVID JOSEPH	SALE	15.80	9.6K	151.7K	182.77K
Apr 01, 2025	WELGUS HOWARD G.	SALE	15.12	10K	151.24K	121.94K
Mar 25, 2025	WATANABE TODD FRANKLIN	SALE	17.56	2.17K	38.13K	925.24K
Mar 24, 2025	WATANABE TODD FRANKLIN	SALE	17.52	1.5K	26.28K	927.41K
Mar 17, 2025	WATANABE TODD FRANKLIN	SALE	17.61	1.2K	21.14K	928.91K
Mar 14, 2025	BURNETT PATRICK	SALE	15.04	12.24K	184.11K	121.94K
Mar 13, 2025	BURNETT PATRICK	SALE	15.10	5.01K	75.63K	121.94K
Mar 04, 2025	BURNETT PATRICK	SALE	13.28	954	12.67K	166.09K
Mar 04, 2025	WATANABE TODD FRANKLIN	SALE	13.28	4.14K	54.93K	930.11K
Mar 03, 2025	BURNETT PATRICK	SALE	13.03	2.82K	36.73K	167.04K
Mar 03, 2025	MATSUDA MASARU	SALE	13.03	3.26K	42.52K	209.43K
Mar 03, 2025	WELGUS HOWARD G.	SALE	13.00	10K	130.05K	131.94K
Mar 03, 2025	WATANABE TODD FRANKLIN	SALE	13.03	20.88K	272.09K	934.25K
Feb 03, 2025	BURNETT PATRICK	SALE	12.70	12.12K	153.87K	114.86K
Feb 03, 2025	WELGUS HOWARD G.	SALE	12.71	10K	127.1K	141.94K
Feb 03, 2025	EDWARDS LARRY TODD	SALE	12.70	2.17K	27.6K	135.56K
Feb 03, 2025	WATANABE TODD FRANKLIN	SALE	12.70	19.3K	245.12K	804.13K
Feb 03, 2025	MATSUDA MASARU	SALE	12.70	8.34K	105.89K	178.69K
Jan 02, 2025	WELGUS HOWARD G.	SALE	14.67	10K	146.71K	151.94K
Dec 31, 2024	BURNETT PATRICK	SALE	14.00	1.69K	23.67K	126.98K
Dec 20, 2024	WATANABE TODD FRANKLIN	SALE	15.17	15K	227.57K	823.43K
Dec 02, 2024	WELGUS HOWARD G.	SALE	12.51	10K	125.13K	161.94K
Nov 30, 2024	MATSUDA MASARU	PURCHASE	7.11	1.66K	11.77K	187.03K
Nov 30, 2024	EDWARDS LARRY TODD	PURCHASE	7.11	1.09K	7.77K	137.73K
Nov 30, 2024	WATANABE TODD FRANKLIN	PURCHASE	7.11	2.04K	14.48K	838.43K
Nov 22, 2024	BURNETT PATRICK	SALE	10.14	16.02K	162.51K	128.67K
Nov 19, 2024	MATSUDA MASARU	SALE	9.68	1.78K	17.19K	181.37K
Nov 15, 2024	BURNETT PATRICK	SALE	10.03	100	1K	128.67K
Nov 14, 2024	BURNETT PATRICK	SALE	10.29	18.38K	189.18K	128.67K
Nov 11, 2024	CURRAN TERRIE	SALE	10.85	8.69K	94.24K	10.14K
Nov 04, 2024	MATSUDA MASARU	SALE	8.68	5.02K	43.55K	178.27K
Nov 04, 2024	WATANABE TODD FRANKLIN	SALE	8.68	13.87K	120.46K	832.39K
Nov 04, 2024	BURNETT PATRICK	SALE	8.68	15.44K	134.09K	179.42K
Nov 01, 2024	WELGUS HOWARD G.	SALE	8.65	10K	86.54K	171.94K
Oct 02, 2024	EDWARDS LARRY TODD	SALE	10.01	3.73K	37.3K	136.64K
Oct 01, 2024	WELGUS HOWARD G.	SALE	9.26	10K	92.62K	181.94K
Sep 24, 2024	TOPPER DAVID JOSEPH	SALE	9.48	11.63K	110.26K	158.37K
Sep 03, 2024	WELGUS HOWARD G.	SALE	10.77	10K	107.7K	191.94K
Aug 19, 2024	BURNETT PATRICK	SALE	8.29	1.73K	14.32K	194.86K
Aug 02, 2024	WATANABE TODD FRANKLIN	SALE	9.02	14.49K	130.65K	846.26K
Aug 02, 2024	BURNETT PATRICK	SALE	9.02	13.21K	119.11K	196.59K
Aug 02, 2024	MATSUDA MASARU	SALE	9.02	5.22K	47.06K	183.29K
Aug 01, 2024	WELGUS HOWARD G.	SALE	9.87	3.39K	33.42K	176.95K
Jul 01, 2024	WELGUS HOWARD G.	SALE	9.31	10K	93.14K	180.34K
Jun 04, 2024	WELGUS HOWARD G.	SALE	8.01	6.46K	51.76K	170.2K
May 31, 2024	WATANABE TODD FRANKLIN	PURCHASE	1.69	4K	6.77K	836.39K
May 31, 2024	MATSUDA MASARU	PURCHASE	1.69	4K	6.77K	185.37K
May 30, 2024	BURNETT PATRICK	SALE	8.75	23K	201.32K	209.79K
May 29, 2024	BURNETT PATRICK	SALE	8.72	49.95K	435.39K	209.79K
May 28, 2024	MATSUDA MASARU	SALE	9.01	1.78K	15.99K	188.51K
May 17, 2024	EDWARDS LARRY TODD	SALE	8.98	7.64K	68.58K	140.36K
May 02, 2024	BURNETT PATRICK	SALE	8.74	9.56K	83.49K	259.75K
May 02, 2024	MOORE MATTHEW RICHARD	SALE	8.74	4.68K	40.9K	145.51K
May 02, 2024	WATANABE TODD FRANKLIN	SALE	8.74	13.78K	120.43K	860.75K
May 02, 2024	MATSUDA MASARU	SALE	8.74	5.02K	43.83K	185.41K
Mar 04, 2024	HERON PATRICK J	PURCHASE	9.50	21.05K	199.99K	8.79M
Mar 04, 2024	BURNETT PATRICK	SALE	11.12	4.78K	53.18K	269.3K
Mar 04, 2024	MATSUDA MASARU	SALE	11.12	3.76K	41.82K	190.42K
Mar 04, 2024	MOORE MATTHEW RICHARD	SALE	11.12	3.47K	38.57K	146.02K
Mar 04, 2024	WATANABE TODD FRANKLIN	SALE	11.12	14.9K	165.74K	874.53K
Feb 28, 2024	WATANABE TODD FRANKLIN	SALE	10.60	2.47K	26.13K	889.44K
Jan 02, 2024	BURNETT PATRICK	SALE	3.54	1.33K	4.69K	57.03K
Nov 21, 2023	MATSUDA MASARU	SALE	1.98	1.85K	3.66K	46.63K
Oct 24, 2023	FRAZIER LIFE SCIENCES VIII, L.P.	PURCHASE	2.50	80K	200K	8.76M
Aug 21, 2023	BURNETT PATRICK	SALE	7.04	1.31K	9.19K	58.36K
May 31, 2023	WATANABE TODD FRANKLIN	PURCHASE	6.38	1.46K	9.33K	515.15K
May 31, 2023	MATSUDA MASARU	SALE	7.80	1.83K	14.28K	42.15K
Apr 17, 2023	WELGUS HOWARD G.	SALE	13.97	8.5K	118.73K	165.83K
Apr 06, 2023	WELGUS HOWARD G.	SALE	12.01	8.5K	102.09K	165.83K
Mar 06, 2023	BURNETT PATRICK	SALE	15.26	851	12.99K	59.96K
Mar 06, 2023	TURNEY PATRICIA A.	SALE	15.26	831	12.68K	62.86K
Mar 06, 2023	BURROWS SCOTT L	SALE	15.26	291	4.44K	59.12K
Mar 06, 2023	LOCK KENNETH A.	SALE	15.26	831	12.68K	63.43K
Mar 06, 2023	OSBORNE DAVID W	SALE	15.26	690	10.53K	268.85K
Mar 06, 2023	WATANABE TODD FRANKLIN	SALE	15.26	2.44K	37.17K	366.66K
Mar 02, 2023	MOORE MATTHEW RICHARD	SALE	16.52	21	346.92	11.69K
Mar 02, 2023	OSBORNE DAVID W	SALE	16.52	15	247.8	254.64K
Mar 02, 2023	LOCK KENNETH A.	SALE	16.52	18	297.36	43.26K
Mar 02, 2023	WATANABE TODD FRANKLIN	SALE	16.52	69	1.14K	369.09K
Mar 02, 2023	BURROWS SCOTT L	SALE	16.52	18	297.36	38.41K
Mar 02, 2023	TURNEY PATRICIA A.	SALE	16.52	18	297.36	45.69K
Mar 02, 2023	BURNETT PATRICK	SALE	16.52	23	379.96	39.81K
Mar 02, 2023	MATSUDA MASARU	SALE	16.52	18	297.36	18.1K
Feb 28, 2023	TURNEY PATRICIA A.	SALE	16.17	936	15.13K	47.13K
Feb 28, 2023	LOCK KENNETH A.	SALE	16.17	936	15.13K	44.69K
Feb 28, 2023	WATANABE TODD FRANKLIN	SALE	16.17	2.34K	37.88K	374.56K
Feb 28, 2023	OSBORNE DAVID W	SALE	16.17	792	12.8K	255.86K
Feb 28, 2023	BURROWS SCOTT L	SALE	16.17	416	6.73K	39.84K
Feb 15, 2023	WELGUS HOWARD G.	SALE	16.98	8.5K	144.35K	165.83K
Feb 14, 2023	WATANABE TODD FRANKLIN	SALE	17.03	100	1.7K	376.91K
Feb 13, 2023	WATANABE TODD FRANKLIN	SALE	17.01	42	714.42	377.42K
Feb 01, 2023	WATANABE TODD FRANKLIN	SALE	17.00	382	6.49K	377.91K
Jan 17, 2023	WELGUS HOWARD G.	SALE	13.72	8.5K	116.65K	165.83K
Jan 03, 2023	BURNETT PATRICK	SALE	15.01	1.48K	22.14K	41.56K
Dec 07, 2022	WATANABE TODD FRANKLIN	SALE	17.06	1K	17.06K	378.91K
Nov 21, 2022	MATSUDA MASARU	SALE	18.19	1.72K	31.29K	19.54K
Nov 15, 2022	WELGUS HOWARD G.	SALE	20.01	3.4K	68.1K	165.83K
Nov 07, 2022	WATANABE TODD FRANKLIN	SALE	18.00	1K	18K	379.91K
Oct 07, 2022	WATANABE TODD FRANKLIN	SALE	19.51	1K	19.51K	380.91K
Oct 04, 2022	WELGUS HOWARD G.	SALE	20.29	6K	121.77K	168.21K
Sep 07, 2022	WATANABE TODD FRANKLIN	SALE	21.51	1K	21.51K	381.91K
Aug 15, 2022	WELGUS HOWARD G.	SALE	24.80	6K	148.79K	174.21K
Aug 05, 2022	HERON PATRICK J	PURCHASE	20.00	250K	5M	8.68M
Aug 05, 2022	FRAZIER LIFE SCIENCES VIII, L.P.	PURCHASE	20.00	250K	5M	8.68M
Aug 05, 2022	WATANABE TODD FRANKLIN	SALE	24.74	2.5K	61.86K	651.87K
Jul 18, 2022	WELGUS HOWARD G.	SALE	24.40	6K	146.37K	180.21K
Jul 08, 2022	WATANABE TODD FRANKLIN	SALE	25.41	7.09K	180.11K	651.87K
Jul 08, 2022	OSBORNE DAVID W	SALE	25.41	2.2K	55.84K	256.65K
Jul 06, 2022	WATANABE TODD FRANKLIN	SALE	22.07	1K	22.07K	658.28K
Jun 24, 2022	ORBIMED ADVISORS LLC	SALE	21.31	35.94K	765.97K	415.14K
Jun 24, 2022	ORBIMED CAPITAL GP VII LLC	SALE	21.31	35.94K	765.97K	415.14K
Jun 06, 2022	WATANABE TODD FRANKLIN	SALE	21.06	1K	21.06K	659.28K
Jun 01, 2022	WELGUS HOWARD G.	SALE	20.62	2.5K	51.54K	181.9K
May 27, 2022	MATSUDA MASARU	SALE	19.73	1.8K	35.42K	16.38K
May 05, 2022	WATANABE TODD FRANKLIN	SALE	21.76	1K	21.76K	658.67K
May 02, 2022	WELGUS HOWARD G.	SALE	20.44	2.5K	51.11K	181.9K
Apr 21, 2022	OSBORNE DAVID W	SALE	20.42	2.2K	44.87K	257.23K
Apr 08, 2022	ORBIMED ADVISORS LLC	SALE	20.71	102.8K	2.13M	451.09K
Apr 07, 2022	ORBIMED ADVISORS LLC	SALE	20.66	177.2K	3.66M	553.89K
Apr 06, 2022	ORBIMED ADVISORS LLC	SALE	20.69	171.2K	3.54M	731.08K
Apr 06, 2022	ORBIMED CAPITAL GP VII LLC	SALE	20.71	102.8K	2.13M	451.09K
Apr 05, 2022	WATANABE TODD FRANKLIN	SALE	21.43	1K	21.43K	659.67K
Apr 01, 2022	WELGUS HOWARD G.	SALE	20.02	7.5K	150.18K	181.9K
Mar 09, 2022	WATANABE TODD FRANKLIN	SALE	17.00	300	5.1K	660.67K
Mar 07, 2022	WATANABE TODD FRANKLIN	SALE	17.11	700	11.97K	660.97K
Mar 07, 2022	BURNETT PATRICK	SALE	16.44	30	493.35	43.04K
Mar 04, 2022	OSBORNE DAVID W	SALE	16.86	828	13.96K	259.45K
Mar 03, 2022	WATANABE TODD FRANKLIN	SALE	16.86	2.49K	41.96K	661.04K
Mar 03, 2022	LOCK KENNETH A.	SALE	16.86	993	16.74K	44.04K
Mar 03, 2022	BURROWS SCOTT L	SALE	16.44	10	164.45	35.26K
Mar 03, 2022	TURNEY PATRICIA A.	SALE	16.44	30	493.35	31.11K
Mar 03, 2022	OSBORNE DAVID W	SALE	16.44	28	460.46	259.43K
Mar 03, 2022	BURNETT PATRICK	SALE	16.86	981	16.54K	43.07K
Mar 01, 2022	WATANABE TODD FRANKLIN	SALE	17.75	2.15K	38.22K	592.63K
Mar 01, 2022	OSBORNE DAVID W	SALE	17.75	775	13.76K	246.98K
Mar 01, 2022	BURROWS SCOTT L	SALE	17.75	420	7.46K	22.26K
Mar 01, 2022	TURNEY PATRICIA A.	SALE	17.75	936	16.62K	18.84K
Mar 01, 2022	LOCK KENNETH A.	SALE	17.75	935	16.6K	31.73K
Feb 09, 2022	WATANABE TODD FRANKLIN	SALE	17.00	1K	17K	594.78K
Jan 05, 2022	WATANABE TODD FRANKLIN	SALE	22.40	300	6.72K	595.48K
Jan 03, 2022	WELGUS HOWARD G.	SALE	21.21	2.5K	53.03K	181.9K
Dec 27, 2021	BURROWS SCOTT L	SALE	20.07	12.56K	252.14K	22.68K
Dec 23, 2021	WELGUS HOWARD G.	SALE	20.16	2.5K	50.4K	181.9K
Dec 08, 2021	WATANABE TODD FRANKLIN	SALE	17.00	1K	17K	594.78K
Nov 05, 2021	WATANABE TODD FRANKLIN	SALE	21.50	1K	21.5K	594.78K
Nov 01, 2021	WELGUS HOWARD G.	SALE	21.81	2.5K	54.52K	181.9K
Oct 05, 2021	WATANABE TODD FRANKLIN	SALE	24.92	2.5K	62.29K	594.78K
Oct 01, 2021	WATANABE TODD FRANKLIN	SALE	25.01	1.5K	37.51K	594.78K
Oct 01, 2021	WELGUS HOWARD G.	SALE	23.87	2.5K	59.68K	181.9K
Sep 07, 2021	WATANABE TODD FRANKLIN	SALE	21.14	1K	21.14K	594.78K
Sep 01, 2021	WELGUS HOWARD G.	SALE	20.71	4.2K	86.97K	182.7K
Aug 05, 2021	WATANABE TODD FRANKLIN	SALE	20.81	1K	20.81K	594.78K
Jul 06, 2021	WATANABE TODD FRANKLIN	SALE	26.58	1.75K	46.52K	594.78K
Jul 01, 2021	WELGUS HOWARD G.	SALE	26.03	1.95K	50.76K	182.15K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE00

SALES373.65K37

NET SHARES-373.65K37

SHARES HELD10.12M37

% NET SHARES-103.69%0%

Frequently Asked Questions