How many institutions own APGE stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own APGE shares is 260, representing 112.99% of the company's common stock.

Who are the major shareholders selling Apogee Therapeutics, Inc. stock?

BANK OF NEW YORK MELLON CORP, in the last quarter, reduced its stake in APGE by -46.54% restricting it's holding to 107.54 thousand shares of worth nearly $4.27M. TD ASSET MANAGEMENT INC also lessened -12% of the APGE shares from its portfolio, reducing its holding to 83.24 thousand shares of worth $3.31M. RHUMBLINE ADVISERS also shunned APGE shares holding by -2.88% last quarter which brought its holding to 47.8 thousand shares worth $1.90M.

Investors who are buying APGE stock?

As per its latest 13F filing, BLACKSTONE INC. increased its stake in APGE by 6.61% in the last quarter. The institutional holder raised its holding to 190.35 thousand shares having worth more than $7.56M. NOVO HOLDINGS A/S also added 11.26% more shares of APGE to its portfolio, raising its holding to 500 thousand shares of worth $19.87M. PLATINUM INVESTMENT MANAGEMENT LTD also increased its APGE shares holding by 8.34% which brought its holding to 93.73 thousand shares worth $3.72M.

APGE's major insiders: who are they?

The insider with the most stakes in APGE is HENDERSON MICHAEL THOMAS , Chief Executive Officer at the company. Additionally, APGE stock is highly held by director Shah Nimish P and Chief Medical Officer Dambkowski Carl among others.

Did an insider recently sell APGE stock?

Company executives, directors, and other insiders own 6.2% percent of Apogee Therapeutics, Inc.'s stock. Within the last six months, there have been 15 transaction(s) in which APGE insiders have sold stock, totaling 73.84K shares. Insiders that have sold shares include HENDERSON JANE, HENDERSON MICHAEL THOMAS, and DAMBKOWSKI CARL.

Which insider recently purchased APGE stock?

There have been 1 transaction(s) during the past 6-months in which Apogee Therapeutics, Inc. insiders have bought stock, totalling 365853 shares

How much of APGE does insiders own?

Around 6.75M Apogee Therapeutics, Inc. shares are held by insiders, which represents about 6.2% of APGE stock.

Who is the insider with the largest stake?

APGE Chief Executive Officer, HENDERSON MICHAEL THOMAS holds the largest portfolio of the company's shares. APGE shares owned by HENDERSON total nearly 1.21 million.

Which institution holds the most shares in APGE?

BLACKSTONE INC. is the largest institutional owner in APGE which holds 190.35 thousand shares worth $7.56M or 0.33% of the total APGE shares outstanding followed by TANG CAPITAL MANAGEMENT LLC with ownership of 200 thousand shares representing 0.34% of the APGE ownership. NOVO HOLDINGS A/S is the third largest stakeholder with 500 thousand shares or 0.86% of the ownership worth more than $19.87M.

Is Apogee Therapeutics, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the APGE is concerned, it is a stock which is optionable.

Is there a short position on APGE's shares?

Number of APGE shares short is 8.47M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding APGE shares are there?

As of today, 54.83M shares of APGE are outstanding.

Is there many float in APGE stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, APGE has 48.65M shares in float.

APGE short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for APGE is 10.45.

Apogee Therapeutics (APGE) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares12.4

Short Percent Of Float22.66

Shares Outstanding54.83M

Shares Float48.65M

Shares Short8.47M

Short Ratio10.45

22.66%

Short % of Float

12.4%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

6.2% Percentage of Shares held by All Insiders

112.99% Percentage of Shares held by All Institutions

120.46% Percentage of Float held by Institutions

260

Number of Institutions Holding Shares

Institutional Ownership

About 112.99% of APGE shares are held by financial institutions. BLACKSTONE INC. is the top corporate investor, holding 190.35K shares valued at $7.56M. A 0.33% stake in Apogee Therapeutics, Inc. is owned by the company. TANG CAPITAL MANAGEMENT LLC owns 200K shares valued at $7.95M, which translates its holding of 0.34% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Sep 30, 2025	BLACKSTONE INC.	0.33%	190.35K	7.56M	11.81K	+6.61%
Sep 30, 2025	TANG CAPITAL MANAGEMENT LLC	0.34%	200K	7.95M	0	0
Sep 30, 2025	NOVO HOLDINGS A/S	0.86%	500K	19.87M	50.61K	+11.26%
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.18%	107.54K	4.27M	-93.61K	-46.54%
Sep 30, 2025	PLATINUM INVESTMENT MANAGEMENT LTD	0.16%	93.73K	3.72M	7.22K	+8.34%
Sep 30, 2025	NUVEEN, LLC	0.14%	83.29K	3.31M	0	0
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.14%	83.24K	3.31M	-11.35K	-12.00%
Sep 30, 2025	DEUTSCHE BANK AG\	0.13%	76.55K	3.04M	52.84K	+222.86%
Sep 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.11%	65.8K	2.61M	23.59K	+55.87%
Sep 30, 2025	ABRDN PLC	0.09%	54.76K	2.18M	54.76K	+100.00%
Sep 30, 2025	EXANE ASSET MANAGEMENT	0.09%	51.54K	2.41M	51.54K	+100.00%
Sep 30, 2025	RHUMBLINE ADVISERS	0.08%	47.8K	1.9M	-1.42K	-2.88%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.07%	43.67K	1.74M	21.91K	+100.63%
Sep 30, 2025	SWISS NATIONAL BANK	0.07%	43.4K	1.72M	800	+1.88%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.07%	38.22K	1.52M	34.57K	+947.49%
Sep 30, 2025	INVESCO LTD.	0.05%	29.14K	1.16M	2.27K	+8.46%
Sep 30, 2025	LEGAL & GENERAL GROUP PLC	0.05%	27.66K	1.1M	-26	-0.09%
Sep 30, 2025	ERSTE ASSET MANAGEMENT GMBH	0.04%	24K	955.92K	0	0
Sep 30, 2025	ALPS ADVISORS INC	0.04%	22.51K	894.16K	-2.34K	-9.43%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.04%	21.99K	873.66K	5.14K	+30.48%
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	19.24K	764.33K	0	0
Sep 30, 2025	MOODY ALDRICH PARTNERS LLC	0.03%	18.01K	715.62K	-3.62K	-16.73%
Sep 30, 2025	BIRCHVIEW CAPITAL, LP	0.03%	16K	635.68K	0	0
Sep 30, 2025	PERSISTENT ASSET PARTNERS LTD	0.03%	14.82K	588.76K	12.39K	+511.09%
Sep 30, 2025	PROFUND ADVISORS LLC	0.02%	14.17K	563.01K	5.19K	+57.79%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.02%	13.7K	544.34K	-2.37K	-14.74%
Sep 30, 2025	PRUDENTIAL FINANCIAL INC	0.02%	12.86K	510.93K	-55.99K	-81.32%
Sep 30, 2025	NATIXIS ADVISORS, L.P.	0.02%	12.48K	496K	-2.56K	-17.00%
Sep 30, 2025	TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY	0.02%	11.64K	463K	0	0
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.02%	9.89K	392.81K	0	0
Sep 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.02%	9.37K	372.43K	-3.07K	-24.68%
Sep 30, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.02%	9.34K	371.12K	1.99K	+27.11%
Sep 30, 2025	HANDELSBANKEN FONDER AB	0.01%	8.5K	338K	0	0
Sep 30, 2025	GLENMEDE INVESTMENT MANAGEMENT, LP	0.01%	8.13K	322.89K	-730	-8.24%
Sep 30, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.01%	8.08K	321.1K	-6.17K	-43.28%
Sep 30, 2025	FMR LLC	11.84%	6.92M	274.79M	9.36K	+0.14%
Sep 30, 2025	UBS GROUP AG	1.37%	799.47K	31.76M	692.31K	+646.07%
Sep 30, 2025	JEFFERIES FINANCIAL GROUP INC.	0.97%	568.08K	22.57M	-74.27K	-11.56%
Sep 30, 2025	SG AMERICAS SECURITIES, LLC	0.23%	134.23K	5.33M	134.23K	+100.00%
Sep 30, 2025	CITADEL ADVISORS LLC	2%	1.17M	46.45M	673.59K	+135.90%
Sep 30, 2025	JPMORGAN CHASE & CO	1.95%	1.14M	45.2M	12.16K	+1.08%
Sep 30, 2025	MERCER GLOBAL ADVISORS INC /ADV	1.66%	970.58K	38.56M	150.21K	+18.31%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.53%	892.2K	35.45M	109.56K	+14.00%
Sep 30, 2025	FRANKLIN RESOURCES INC	1.25%	730.76K	29.03M	-121.77K	-14.28%
Sep 30, 2025	BLACKROCK, INC.	4.6%	2.69M	106.72M	123.49K	+4.82%
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	1.28%	750.53K	29.82M	-10.32K	-1.36%
Sep 30, 2025	BARCLAYS PLC	1.1%	642.32K	25.52M	33.49K	+5.50%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.03%	599.62K	23.82M	-59.57K	-9.04%
Sep 30, 2025	SOFINNOVA INVESTMENTS, INC.	0.97%	565.42K	22.46M	489.24K	+642.21%
Sep 30, 2025	POLAR CAPITAL HOLDINGS PLC	0.9%	524.09K	20.82M	29.09K	+5.88%
Sep 30, 2025	FRONTIER CAPITAL MANAGEMENT CO LLC	0.64%	374.41K	14.88M	65.34K	+21.14%
Sep 30, 2025	OPALEYE MANAGEMENT INC.	0.62%	363.26K	14.43M	363.26K	+100.00%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.55%	319.9K	12.71M	53.52K	+20.09%
Sep 30, 2025	GRANAHAN INVESTMENT MANAGEMENT, LLC	0.23%	132.4K	5.26M	1.26K	+0.96%
Sep 30, 2025	UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH	0.23%	131.44K	5.22M	5.61K	+4.46%
Sep 30, 2025	CAPITAL WORLD INVESTORS	0.22%	127.62K	5.07M	-66.28K	-34.18%
Sep 30, 2025	DIADEMA PARTNERS LP	0.22%	127.4K	5.06M	-28.9K	-18.49%
Sep 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	2.6%	1.52M	60.46M	563.13K	+58.74%
Sep 30, 2025	JANUS HENDERSON GROUP PLC	0.83%	485.98K	19.31M	-23.34K	-4.58%
Sep 30, 2025	MORGAN STANLEY	0.8%	464.96K	18.47M	-9.74K	-2.05%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	0.74%	430.46K	17.1M	185.33K	+75.60%
Sep 30, 2025	VESTAL POINT CAPITAL, LP	0.73%	425K	16.89M	425K	+100.00%
Sep 30, 2025	FIRST TURN MANAGEMENT, LLC	0.69%	402.81K	16M	91.32K	+29.32%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.67%	393.91K	15.65M	-115.08K	-22.61%
Sep 30, 2025	GREAT POINT PARTNERS LLC	0.52%	304K	12.08M	304K	+100.00%
Sep 30, 2025	COMMODORE CAPITAL LP	0.5%	290K	11.52M	0	0
Sep 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.37%	217.21K	8.63M	-37.56K	-14.74%
Sep 30, 2025	CANDRIAM S.C.A.	0.22%	126.08K	5.01M	126.08K	+100.00%
Sep 30, 2025	VR ADVISER, LLC	14.54%	8.49M	337.44M	0	0
Sep 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	8.08%	4.72M	187.67M	917.99K	+24.12%
Sep 30, 2025	RTW INVESTMENTS, LP	4.64%	2.71M	107.75M	0	0
Sep 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	3.69%	2.16M	85.76M	-152.25K	-6.59%
Sep 30, 2025	FAIRMOUNT FUNDS MANAGEMENT LLC	3.51%	2.05M	81.39M	0	0
Sep 30, 2025	STATE STREET CORP	2.83%	1.66M	65.77M	396.29K	+31.47%
Sep 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.21%	124.05K	4.93M	48.15K	+63.45%
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.21%	122.38K	4.86M	6.68K	+5.77%
Sep 30, 2025	CAPTION MANAGEMENT, LLC	0.19%	110.5K	4.39M	15.5K	+16.32%
Sep 30, 2025	ARROWMARK COLORADO HOLDINGS LLC	0.19%	109.41K	4.35M	0	0
Sep 30, 2025	VANGUARD GROUP INC	3.84%	2.25M	89.22M	136.69K	+6.48%
Sep 30, 2025	BRAIDWELL LP	2.46%	1.44M	57.16M	-39.77K	-2.69%
Sep 30, 2025	ALLIANCEBERNSTEIN L.P.	2.43%	1.42M	56.38M	30.98K	+2.23%
Sep 30, 2025	PERCEPTIVE ADVISORS LLC	2.31%	1.35M	53.71M	169.84K	+14.37%
Sep 30, 2025	AFFINITY ASSET ADVISORS, LLC	2.01%	1.17M	46.62M	481.53K	+69.60%
Sep 30, 2025	NORTHERN TRUST CORP	0.49%	284.48K	11.3M	20.3K	+7.68%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	0.4%	235K	9.34M	-1.06M	-81.79%
Sep 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.37%	215.85K	8.6M	96.6K	+81.01%
Jun 30, 2025	NOVO HOLDINGS A/S	0.77%	449.39K	19.52M	449.39K	+100.00%
Jun 30, 2025	VR ADVISER, LLC	14.54%	8.49M	368.86M	0	0
Jun 30, 2025	FMR LLC	11.82%	6.91M	299.98M	-586.53K	-7.83%
Jun 30, 2025	RTW INVESTMENTS, LP	4.64%	2.71M	117.79M	0	0
Jun 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	3.95%	2.31M	100.36M	-28.81K	-1.23%
Jun 30, 2025	FAIRMOUNT FUNDS MANAGEMENT LLC	3.51%	2.05M	88.97M	0	0
Jun 30, 2025	BRAIDWELL LP	2.53%	1.48M	64.21M	-61.85K	-4.02%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	2.38%	1.39M	60.29M	107.2K	+8.37%
Jun 30, 2025	PARADIGM BIOCAPITAL ADVISORS LP	1.64%	958.63K	41.63M	-3.08K	-0.32%
Jun 30, 2025	WOODLINE PARTNERS LP	1.49%	870.21K	37.79M	-190.85K	-17.99%
Jun 30, 2025	DIADEMA PARTNERS LP	0.27%	156.3K	6.79M	30K	+23.75%
Jun 30, 2025	NORTHERN TRUST CORP	0.45%	264.19K	11.47M	-50.29K	-15.99%
Jun 30, 2025	VICTORY CAPITAL MANAGEMENT INC	0.44%	254.77K	11.06M	21.79K	+9.35%
Jun 30, 2025	IKARIAN CAPITAL, LLC	0.4%	232.05K	10.08M	232.05K	+100.00%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.34%	201.15K	8.74M	-13.08K	-6.11%
Jun 30, 2025	TANG CAPITAL MANAGEMENT LLC	0.34%	200K	8.69M	0	0
Jun 30, 2025	CAPITAL WORLD INVESTORS	0.33%	193.9K	8.42M	0	0
Jun 30, 2025	BLACKSTONE INC.	0.31%	178.55K	7.75M	-5.2K	-2.83%
Jun 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.27%	158.64K	6.89M	45.91K	+40.72%
Jun 30, 2025	AMERIPRISE FINANCIAL INC	0.27%	156.11K	6.78M	59.78K	+62.06%
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.26%	152.7K	6.63M	63.4K	+71.00%
Jun 30, 2025	MERCER GLOBAL ADVISORS INC /ADV	1.4%	820.38K	35.63M	-819.8K	-49.98%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.34%	782.64K	33.99M	-53.05K	-6.35%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	1.3%	760.84K	33.05M	-61.01K	-7.42%
Jun 30, 2025	BARCLAYS PLC	1.04%	608.82K	26.44M	110.2K	+22.10%
Jun 30, 2025	SIREN, L.L.C.	1.02%	594.99K	25.84M	0	0
Jun 30, 2025	MORGAN STANLEY	0.81%	474.7K	20.62M	-45.24K	-8.70%
Jun 30, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.09%	55.4K	2.41M	8.74K	+18.73%
Jun 30, 2025	COMMODORE CAPITAL LP	0.5%	290K	12.59M	0	0
Jun 30, 2025		0.27%	156.3K	6.79M	30K	+23.75%
Jun 30, 2025	WELLINGTON MANAGEMENT GROUP LLP	6.51%	3.81M	165.28M	-1.68M	-30.63%
Jun 30, 2025	VANGUARD GROUP INC	3.61%	2.11M	91.59M	26.33K	+1.26%
Jun 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	2.21%	1.29M	56.04M	563.46K	+77.51%
Jun 30, 2025	JPMORGAN CHASE & CO	1.93%	1.13M	48.88M	162.94K	+16.93%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	1.13%	659.19K	28.63M	368.49K	+126.76%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.87%	508.99K	22.11M	83.11K	+19.51%
Jun 30, 2025	FIRST TURN MANAGEMENT, LLC	0.53%	311.49K	13.53M	81.82K	+35.62%
Jun 30, 2025	STATE STREET CORP	2.16%	1.26M	54.69M	-54.49K	-4.15%
Jun 30, 2025	CITADEL ADVISORS LLC	0.85%	495.66K	21.53M	429.48K	+648.93%
Jun 30, 2025	POLAR CAPITAL HOLDINGS PLC	0.85%	495K	21.5M	-55K	-10.00%
Jun 30, 2025	RAFFERTY ASSET MANAGEMENT, LLC	0.07%	42.21K	1.83M	-790	-1.84%
Jun 30, 2025	POINT72 ASSET MANAGEMENT, L.P.	2.11%	1.23M	53.44M	837.89K	+213.48%
Jun 30, 2025	PERCEPTIVE ADVISORS LLC	2.02%	1.18M	51.34M	59.38K	+5.29%
Jun 30, 2025	AFFINITY ASSET ADVISORS, LLC	1.18%	691.9K	30.05M	-459.3K	-39.90%
Jun 30, 2025	JEFFERIES FINANCIAL GROUP INC.	1.1%	642.36K	27.9M	220.56K	+52.29%
Jun 30, 2025	JANUS HENDERSON GROUP PLC	0.87%	509.32K	22.12M	-1.28M	-71.61%
Jun 30, 2025	JENNISON ASSOCIATES LLC	0.46%	270.37K	11.74M	-23.39K	-7.96%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.46%	266.38K	11.57M	-5.5K	-2.02%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	0.42%	245.13K	10.65M	-15.2K	-5.84%
Jun 30, 2025	D. E. SHAW & CO., INC.	0.33%	194.53K	8.45M	185.75K	+2,116.59%
Jun 30, 2025	BLACKROCK, INC.	4.39%	2.56M	111.29M	-348.29K	-11.97%
Jun 30, 2025	HIGHVISTA STRATEGIES LLC	0.08%	45.05K	1.96M	1.86K	+4.31%
Jun 30, 2025	FRANKLIN RESOURCES INC	1.46%	852.53K	37.03M	-23.55K	-2.69%
Jun 30, 2025	FRONTIER CAPITAL MANAGEMENT CO LLC	0.53%	309.07K	13.42M	200.25K	+184.02%
Jun 30, 2025	GRANAHAN INVESTMENT MANAGEMENT, LLC	0.22%	131.14K	5.7M	22.8K	+21.04%
Jun 30, 2025	SCHRODER INVESTMENT MANAGEMENT GROUP	0.2%	119.25K	5.18M	22.25K	+22.94%
Jun 30, 2025	ARROWMARK COLORADO HOLDINGS LLC	0.19%	109.41K	4.75M	0	0
Jun 30, 2025	CAPTION MANAGEMENT, LLC	0.1%	57.6K	2.5M	20.1K	+53.60%
Jun 30, 2025	TD ASSET MANAGEMENT INC	0.16%	94.59K	4.11M	-6.8K	-6.71%
Jun 30, 2025	MARSHALL WACE, LLP	0.16%	90.57K	3.93M	78.97K	+680.83%
Jun 30, 2025	PLATINUM INVESTMENT MANAGEMENT LTD	0.15%	86.51K	3.76M	-9.13K	-9.55%
Jun 30, 2025	BOOTHBAY FUND MANAGEMENT, LLC	0.15%	85.18K	3.7M	85.18K	+100.00%
Jun 30, 2025	STEMPOINT CAPITAL LP	0.14%	84.47K	3.67M	84.47K	+100.00%
Jun 30, 2025	WEISS ASSET MANAGEMENT LP	0.14%	82.3K	3.57M	82.3K	+100.00%
Jun 30, 2025	SOFINNOVA INVESTMENTS, INC.	0.13%	76.18K	3.31M	76.18K	+100.00%
Jun 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.13%	75.9K	3.3M	-2.5K	-3.19%
Jun 30, 2025	AVIDITY PARTNERS MANAGEMENT LP	0.11%	65K	2.82M	65K	+100.00%
Jun 30, 2025	CAPITOLIS LIQUID GLOBAL MARKETS LLC	0.11%	62.8K	2.73M	62.8K	+100.00%
Mar 31, 2025	BLACKSTONE INC.	0.32%	183.75K	6.86M	103.75K	+129.68%
Mar 31, 2025	PARADIGM BIOCAPITAL ADVISORS LP	1.65%	961.71K	35.93M	-322.06K	-25.09%
Mar 31, 2025	TWO SIGMA INVESTMENTS, LP	0.43%	252.14K	9.42M	-14.35K	-5.38%
Mar 31, 2025	VANGUARD GROUP INC	3.58%	2.08M	77.81M	-14.99K	-0.71%
Mar 31, 2025	JANUS HENDERSON GROUP PLC	3.08%	1.79M	71.29M	658.73K	+58.03%
Mar 31, 2025	ALLIANCEBERNSTEIN L.P.	2.2%	1.28M	47.86M	-74.24K	-5.48%
Mar 31, 2025	FRANKLIN RESOURCES INC	1.51%	876.08K	32.73M	9.89K	+1.14%
Mar 31, 2025		0.19%	110.86K	4.14M	110.86K	+100.00%
Mar 31, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.19%	112.73K	4.21M	112.73K	+100.00%
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.44%	835.7K	31.23M	19.58K	+2.40%
Mar 31, 2025	MERCER GLOBAL ADVISORS INC /ADV	2.82%	1.64M	61.28M	920.08K	+127.77%
Mar 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	4.02%	2.34M	87.41M	-265.75K	-10.20%
Mar 31, 2025	OCTAGON CAPITAL ADVISORS LP	18.39%	10.7M	14.87M	10.7M	+100.00%
Mar 31, 2025	VR ADVISER, LLC	14.59%	8.49M	317.31M	0	0
Mar 31, 2025	FMR LLC	12.88%	7.49M	279.96M	-5.76K	-0.08%
Mar 31, 2025	AFFINITY ASSET ADVISORS, LLC	1.98%	1.15M	43.01M	219.47K	+23.56%
Mar 31, 2025	PERCEPTIVE ADVISORS LLC	1.93%	1.12M	41.95M	75.54K	+7.21%
Mar 31, 2025	WOODLINE PARTNERS LP	1.82%	1.06M	39.64M	45.45K	+4.47%
Mar 31, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.25%	727K	27.16M	486.8K	+202.66%
Mar 31, 2025	JPMORGAN CHASE & CO	1.65%	962.63K	35.96M	925.38K	+2,483.90%
Mar 31, 2025	RA CAPITAL MANAGEMENT, L.P.	2.7%	1.57M	58.64M	0	0
Mar 31, 2025	BRAIDWELL LP	2.65%	1.54M	57.55M	0	0
Mar 31, 2025	STATE STREET CORP	2.26%	1.31M	49.08M	-153.36K	-10.45%
Mar 31, 2025	VICTORY CAPITAL MANAGEMENT INC	0.4%	232.98K	8.7M	9.92K	+4.45%
Mar 31, 2025	FIRST TURN MANAGEMENT, LLC	0.39%	229.68K	8.58M	-23.05K	-9.12%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.37%	214.23K	8M	103.4K	+93.30%
Mar 31, 2025	JEFFERIES FINANCIAL GROUP INC.	0.72%	421.8K	15.76M	-465.7K	-52.47%
Mar 31, 2025	NORTHERN TRUST CORP	0.54%	314.48K	11.75M	-12.81K	-3.92%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	1.41%	821.85K	30.71M	-230.75K	-21.92%
Mar 31, 2025	UBS GROUP AG	1.21%	701.91K	26.22M	160.62K	+29.67%
Mar 31, 2025	SIREN, L.L.C.	1.02%	594.99K	22.23M	-152.33K	-20.38%
Mar 31, 2025	POLAR CAPITAL HOLDINGS PLC	0.95%	550K	20.55M	550K	+100.00%
Mar 31, 2025	MORGAN STANLEY	0.89%	519.94K	19.42M	310.41K	+148.14%
Mar 31, 2025	JENNISON ASSOCIATES LLC	0.5%	293.76K	10.97M	-18.63K	-5.97%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.5%	290.7K	10.86M	-117.32K	-28.75%
Mar 31, 2025	BARCLAYS PLC	0.86%	498.63K	18.63M	21.87K	+4.59%
Mar 31, 2025	CAPTION MANAGEMENT, LLC	0.26%	151.3K	5.65M	126.3K	+505.20%
Mar 31, 2025	COMMODORE CAPITAL LP	0.5%	290K	10.83M	0	0
Mar 31, 2025	VOLORIDGE INVESTMENT MANAGEMENT, LLC	0.29%	167.99K	6.28M	126.89K	+308.68%
Mar 31, 2025	TANG CAPITAL MANAGEMENT LLC	0.34%	200K	7.47M	100K	+100.00%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	9.43%	5.49M	204.95M	968.39K	+21.44%
Mar 31, 2025	BLACKROCK, INC.	5%	2.91M	108.75M	-134.13K	-4.41%
Mar 31, 2025	RTW INVESTMENTS, LP	4.66%	2.71M	101.32M	0	0
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.73%	425.88K	15.91M	320.34K	+303.52%
Mar 31, 2025	POINT72 ASSET MANAGEMENT, L.P.	0.67%	392.49K	14.66M	89.75K	+29.65%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.47%	271.88K	10.16M	-5.61K	-2.02%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.45%	260.34K	9.73M	130.16K	+99.99%
Mar 31, 2025	CAPITAL WORLD INVESTORS	0.33%	193.9K	7.24M	-11.21K	-5.46%

Insiders

Among the APGE insiders holding of 6.2% of the stake in company, HENDERSON MICHAEL THOMAS, Chief Executive Officer, holds the largest shares of 1.21M. SHAH NIMISH P, director, is the second largest APGE insider with ownership of 365.85K shares. DAMBKOWSKI CARL, Chief Medical Officer, stands third with possession of 271.11K shares of that stake.

Insiders	Designation	Shares Held
HENDERSON MICHAEL THOMAS	Chief Executive Officer	1.21M
SHAH NIMISH P	director	365.85K
DAMBKOWSKI CARL	Chief Medical Officer	271.11K
HENDERSON JANE	Chief Financial Officer	185.37K
FAIRMOUNT FUNDS MANAGEMENT LLC	director	55.91K
GOTTESDIENER ANDREW	director	47.76K
MCKENNA MARK C.	director	7.5K

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Jan 06, 2026	HENDERSON JANE	SALE	80.00	2K	160K	185.37K
Jan 02, 2026	HENDERSON JANE	SALE	75.20	4.08K	306.82K	187.37K
Dec 19, 2025	HENDERSON JANE	SALE	80.00	1.5K	120K	193.37K
Dec 10, 2025	HENDERSON MICHAEL THOMAS	SALE	76.58	560	42.88K	1.21M
Dec 04, 2025	HENDERSON MICHAEL THOMAS	SALE	75.01	40K	3M	1.23M
Dec 04, 2025	HENDERSON JANE	SALE	75.00	1.5K	112.5K	194.87K
Dec 04, 2025	DAMBKOWSKI CARL	SALE	75.00	10.9K	817.5K	271.11K
Nov 25, 2025	HENDERSON JANE	SALE	70.00	1.5K	105K	196.37K
Nov 14, 2025	HENDERSON JANE	SALE	65.00	2K	130K	197.87K
Nov 13, 2025	HENDERSON MICHAEL THOMAS	SALE	64.52	100	6.45K	1.27M
Nov 11, 2025	HENDERSON JANE	SALE	60.00	1K	60K	199.87K
Nov 05, 2025	DAMBKOWSKI CARL	SALE	56.51	678	38.31K	282.01K
Oct 10, 2025	SHAH NIMISH P	PURCHASE	0.00	365.85K	-	365.85K
Oct 01, 2025	DAMBKOWSKI CARL	SALE	39.80	5.11K	203.38K	284.73K
Sep 03, 2025	DAMBKOWSKI CARL	SALE	38.55	190	7.32K	233.55K
Aug 06, 2025	DAMBKOWSKI CARL	SALE	37.78	2.73K	102.95K	236.27K
Jul 02, 2025	DAMBKOWSKI CARL	SALE	46.26	746	34.51K	239K
Jun 04, 2025	DAMBKOWSKI CARL	SALE	36.96	2.73K	100.72K	241.72K
May 07, 2025	DAMBKOWSKI CARL	SALE	35.75	2.73K	97.42K	244.45K
Apr 02, 2025	DAMBKOWSKI CARL	SALE	37.59	889	33.42K	247.17K
Mar 05, 2025	DAMBKOWSKI CARL	SALE	30.48	1.59K	48.46K	251.03K
Mar 05, 2025	HENDERSON MICHAEL THOMAS	SALE	30.62	2.67K	81.88K	1.29M
Feb 05, 2025	HENDERSON MICHAEL THOMAS	SALE	40.58	15K	608.7K	1.3M
Feb 05, 2025	DAMBKOWSKI CARL	SALE	40.69	3.52K	143.23K	252.62K
Jan 08, 2025	HENDERSON MICHAEL THOMAS	SALE	49.38	2.87K	141.62K	1.31M
Jan 02, 2025	DAMBKOWSKI CARL	SALE	47.92	100	4.79K	255.35K
Dec 12, 2024	MCKENNA MARK C.	PURCHASE	49.02	7.5K	367.65K	7.5K
Dec 11, 2024	DAMBKOWSKI CARL	SALE	50.00	455	22.75K	258.07K
Dec 04, 2024	DAMBKOWSKI CARL	SALE	46.07	6.67K	307.06K	260.8K
Dec 04, 2024	HENDERSON MICHAEL THOMAS	SALE	47.19	1.67K	78.9K	1.32M
Oct 02, 2024	HENDERSON MICHAEL THOMAS	SALE	56.74	9.71K	551.06K	1.35M
Oct 02, 2024	DAMBKOWSKI CARL	SALE	56.86	925	52.6K	274.13K
Sep 04, 2024	DAMBKOWSKI CARL	SALE	48.06	787	37.82K	280.79K
Sep 04, 2024	HENDERSON MICHAEL THOMAS	SALE	48.23	14.36K	692.53K	1.39M
Aug 23, 2024	HENDERSON JANE	SALE	48.26	6K	289.56K	200.87K
Aug 07, 2024	DAMBKOWSKI CARL	SALE	42.56	670	28.52K	287.46K
Aug 07, 2024	HENDERSON MICHAEL THOMAS	SALE	42.17	100	4.22K	1.43M
Aug 17, 2023	MCKENNA MARK C.	AWARD	23.60	100K	2.36M	150K
Jul 13, 2023	FAIRMOUNT FUNDS MANAGEMENT LLC	PURCHASE	17.00	55.91K	950.52K	55.91K
Jul 13, 2023	GOTTESDIENER ANDREW	AWARD	17.00	47.76K	811.89K	47.76K
Jul 13, 2023	SHAH NIMISH P	AWARD	17.00	47.76K	811.89K	47.76K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE365.85K1

SALES73.84K15

NET SHARES292.01K14

SHARES HELD6.75M16

% NET SHARES-95.67%-12.5%

Frequently Asked Questions