How many institutions own ANNX stock?

A company's 13F filings with the Securities and Exchange Commission (SEC) provides investors with comprehensive information about institutional ownership in a listed company, a sign of strength in terms of how many institutions have confidence in that company. The number of institutional investors who currently own ANNX shares is 191, representing 79.2% of the company's common stock.

Who are the major shareholders selling Annexon, Inc. stock?

MANUFACTURERS LIFE INSURANCE COMPANY, THE, in the last quarter, reduced its stake in ANNX by -1.94% restricting it's holding to 130.1 thousand shares of worth nearly $655.09K. RHUMBLINE ADVISERS also lessened -4.63% of the ANNX shares from its portfolio, reducing its holding to 126.46 thousand shares of worth $634.83M. METLIFE INVESTMENT MANAGEMENT, LLC also shunned ANNX shares holding by -12.49% last quarter which brought its holding to 39.06 thousand shares worth $196.08K.

Investors who are buying ANNX stock?

As per its latest 13F filing, MARSHALL WACE, LLP increased its stake in ANNX by 100% in the last quarter. The institutional holder raised its holding to 521 thousand shares having worth more than $2.62M. UBS GROUP AG also added 8.95% more shares of ANNX to its portfolio, raising its holding to 377.1 thousand shares of worth $1.89B. BANK OF NEW YORK MELLON CORP also increased its ANNX shares holding by 17.36% which brought its holding to 361.68 thousand shares worth $1.82M.

ANNX's major insiders: who are they?

The insider with the most stakes in ANNX is Satter Muneer A , director at the company. Additionally, ANNX stock is highly held by 10 percent owner Bain Capital Life Sciences Investors, LLC and 10 percent owner Clarus Lifesciences III, L.P. among others.

Did an insider recently sell ANNX stock?

Company executives, directors, and other insiders own 0.33% percent of Annexon, Inc.'s stock. Within the last six months, there have been 0 transaction(s) in which ANNX insiders have sold stock, totaling 0 shares. Insiders that have sold shares include OVERDORF MICHAEL, YEDNOCK TED, and LEW JENNIFER.

Which insider recently purchased ANNX stock?

There have been 11 transaction(s) during the past 6-months in which Annexon, Inc. insiders have bought stock, totalling 2376188 shares

How much of ANNX does insiders own?

Around 44.52M Annexon, Inc. shares are held by insiders, which represents about 0.33% of ANNX stock.

Who is the insider with the largest stake?

ANNX director, Satter Muneer A holds the largest portfolio of the company's shares. ANNX shares owned by Satter total nearly 9.73 million.

Which institution holds the most shares in ANNX?

MARSHALL WACE, LLP is the largest institutional owner in ANNX which holds 521 thousand shares worth $2.62M or 0.35% of the total ANNX shares outstanding followed by UBS GROUP AG with ownership of 377.1 thousand shares representing 0.25% of the ANNX ownership. BANK OF NEW YORK MELLON CORP is the third largest stakeholder with 361.68 thousand shares or 0.24% of the ownership worth more than $1.82M.

Is Annexon, Inc. stock optionable?

Stock options give the owner the ability but not the obligation to buy or sell a security at a predetermined price and date. Stock options can be classified into two types: puts and calls. A put is a bet on falling stock, and a call is a bet on rising stock. As far as the ANNX is concerned, it is a stock which is optionable.

Is there a short position on ANNX's shares?

Number of ANNX shares short is 17.22M. Shares short is a market sentiment in which investors have sold their shares short in a given stock but have not yet covered them or closed them out.

About how many outstanding ANNX shares are there?

As of today, 149.06M shares of ANNX are outstanding.

Is there many float in ANNX stock?

Float represents the number of tradeable shares in a specific stock. By subtracting restricted and closely-held shares from a firm's total outstanding shares, we can calculate its floating stock. The term "closely-held shares" refers to shares held by employees, major shareholders, and company insiders. At present, ANNX has 111.26M shares in float.

ANNX short ratio: what is it?

Short ratio is calculated by dividing the number of short shares, short interest or bets that shareholders will sell short from the average daily volume. A higher ratio indicates longer times needed to repurchase borrowed shares (sold). The short ratio for ANNX is 6.63.

Annexon (ANNX) insider trading activity: Get Latest News Today

Stock Outstanding Shares

Making an investment decision in the stock market involves a certain amount of risk, so it's important to thoroughly review a company's stock before making any decisions. Stock float, number of short positions and outstanding shares are among the many factors an investor should take into account.

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares11.55

Short Percent Of Float13.54

Shares Outstanding149.06M

Shares Float111.26M

Shares Short17.22M

Short Ratio6.63

13.54%

Short % of Float

11.55%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

0.33% Percentage of Shares held by All Insiders

79.2% Percentage of Shares held by All Institutions

79.46% Percentage of Float held by Institutions

191

Number of Institutions Holding Shares

Institutional Ownership

About 79.2% of ANNX shares are held by financial institutions. MARSHALL WACE, LLP is the top corporate investor, holding 521K shares valued at $2.62M. A 0.35% stake in Annexon, Inc. is owned by the company. UBS GROUP AG owns 377.1K shares valued at $1.89B, which translates its holding of 0.25% of the stake in the company.

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	MARSHALL WACE, LLP	0.35%	521K	2.62M	521K	+100.00%
Dec 31, 2025	UBS GROUP AG	0.25%	377.1K	1.89B	30.97K	+8.95%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.24%	361.68K	1.82M	53.49K	+17.36%
Dec 31, 2025	TWO SIGMA INVESTMENTS, LP	0.22%	332.04K	1.67B	52.9K	+18.95%
Dec 31, 2025	CAPTRUST FINANCIAL ADVISORS	0.02%	31.59K	158.56K	31.59K	+100.00%
Dec 31, 2025	BARCLAYS PLC	0.19%	289.96K	1.46B	142.03K	+96.01%
Dec 31, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.18%	272.81K	1.37M	272.81K	+100.00%
Dec 31, 2025	XTX TOPCO LTD	0.16%	243.31K	1.22B	95.47K	+64.58%
Dec 31, 2025	IEQ CAPITAL, LLC	0.12%	182.98K	918.57K	32.66K	+21.73%
Dec 31, 2025	ADVISOR GROUP HOLDINGS, INC.	0.1%	147.38K	739.82M	0	0
Dec 31, 2025	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.09%	137.8K	691.76M	0	0
Dec 31, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.09%	130.1K	655.09K	-2.57K	-1.94%
Dec 31, 2025	RHUMBLINE ADVISERS	0.08%	126.46K	634.83M	-6.14K	-4.63%
Dec 31, 2025	JUMP FINANCIAL, LLC	0.08%	122.86K	616.75K	122.86K	+100.00%
Dec 31, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.36%	534.99K	2.69M	59.06K	+12.41%
Dec 31, 2025	CITIZENS FINANCIAL GROUP INC/RI	0.03%	40K	200.8K	0	0
Dec 31, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	39.06K	196.08K	-5.57K	-12.49%
Dec 31, 2025	COMERICA BANK	0.02%	32.36K	162.43K	0	0
Dec 31, 2025	MARINER, LLC	0.02%	31.34K	157.35K	31.34K	+100.00%
Dec 31, 2025	CWM, LLC	0.02%	30.3K	152K	6.81K	+28.99%
Dec 31, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.02%	29.57K	148.43K	-4.91K	-14.24%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.71%	1.06M	5.31M	266.81K	+33.76%
Dec 31, 2025	AXQ CAPITAL, LP	0.02%	29.11K	146.12K	1.24K	+4.45%
Dec 31, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.02%	28.11K	141.09K	0	0
Dec 31, 2025	SG AMERICAS SECURITIES, LLC	0.02%	28.07K	141K	17.07K	+155.26%
Dec 31, 2025	PROSHARE ADVISORS LLC	0.02%	24.7K	123.98K	4.41K	+21.74%
Dec 31, 2025	CITIGROUP INC	0.02%	23.64K	118.67K	16.81K	+246.22%
Dec 31, 2025	DNB ASSET MANAGEMENT AS	0.08%	118.32K	593.99K	33.8K	+39.99%
Dec 31, 2025	J. SAFRA SARASIN HOLDING AG	0.08%	117.77K	591.2K	-105.45K	-47.24%
Dec 31, 2025	CITADEL ADVISORS LLC	0.05%	70.4K	353.41M	9.2K	+15.03%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.04%	61.57K	309.09M	41.83K	+211.93%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.95%	2.9M	14.58B	465.95K	+19.12%
Dec 31, 2025	MORGAN STANLEY	1.92%	2.86M	14.34B	-173.71K	-5.73%
Dec 31, 2025	TFG ASSET MANAGEMENT GP LTD	1.36%	2.03M	10.2M	-80K	-3.79%
Dec 31, 2025	ALLEGHENY FINANCIAL GROUP LTD	0.03%	42.9K	215.36K	0	0
Dec 31, 2025	ENTRYPOINT CAPITAL, LLC	0.03%	42.77K	214.73K	22.8K	+114.18%
Dec 31, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	42.52K	213.47K	15.85K	+59.41%
Dec 31, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	36.08K	181.14K	823	+2.33%
Dec 31, 2025	LIDO ADVISORS, LLC	0.02%	34.95K	106.6K	0	0
Dec 31, 2025	LANDING POINT FINANCIAL GROUP, LLC	0.02%	34.9K	175.2K	34.9K	+100.00%
Dec 31, 2025	SEI INVESTMENTS CO	0.04%	58.26K	292.46K	58.26K	+100.00%
Dec 31, 2025	JPMORGAN CHASE & CO	0.04%	53.73K	269.72K	6.84K	+14.60%
Dec 31, 2025	VIRTUS INVESTMENT ADVISERS, INC.	0.04%	53.53K	268.71K	11.54K	+27.48%
Dec 31, 2025	WINTON GROUP LTD	0.04%	53.4K	268.07K	53.4K	+100.00%
Dec 31, 2025	PROFUND ADVISORS LLC	0.04%	53.01K	266.1K	53.01K	+100.00%
Dec 31, 2025	JANE STREET GROUP, LLC	0.04%	52.9K	265.56M	40.8K	+337.19%
Dec 31, 2025	TD ASSET MANAGEMENT INC	0.03%	46.85K	235.18K	0	0
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.03%	44.8K	224.9M	28.7K	+178.26%
Dec 31, 2025	STATE STREET CORP	3.12%	4.65M	23.35M	2.6M	+126.90%
Dec 31, 2025	NUVEEN, LLC	1.96%	2.92M	14.63B	2.23M	+327.12%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	1.19%	1.77M	8.88B	-637.69K	-26.50%
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	1.9%	2.84M	14.24B	14.03K	+0.50%
Dec 31, 2025	VANGUARD GROUP INC	5.2%	7.75M	38.92B	1.92M	+32.87%
Dec 31, 2025	BLACKROCK, INC.	6.01%	8.96M	44.98B	1.06M	+13.44%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	1.08%	1.61M	8.06B	311.28K	+24.05%
Dec 31, 2025	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.61%	903.44K	4.54M	-76.85K	-7.84%
Dec 31, 2025	ACADIAN ASSET MANAGEMENT LLC	0.58%	861.25K	4.32M	328.88K	+61.78%
Dec 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.54%	802.6K	4.03B	49.02K	+6.51%
Dec 31, 2025	AQR CAPITAL MANAGEMENT LLC	0.52%	776.31K	3.9M	202.18K	+35.22%
Dec 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.48%	718.68K	3.61M	-48.28K	-6.29%
Dec 31, 2025	MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	0.43%	642.04K	3.22M	-424.89K	-39.82%
Dec 31, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.4%	601.2K	3.02M	195.25K	+48.10%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.38%	573.75K	2.88M	164.27K	+40.12%
Dec 31, 2025	DEUTSCHE BANK AG\	0.38%	560.74K	2.81M	-943.61K	-62.73%
Sep 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.39%	583.91K	1.78M	0	0
Sep 30, 2025	SUMMITTX CAPITAL, L.P.	0.16%	241.99K	738.07K	241.99K	+100.00%
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.19%	279.13K	851.36K	77.97K	+38.76%
Sep 30, 2025	ROYAL BANK OF CANADA	0.19%	285.85K	871K	40.65K	+16.58%
Sep 30, 2025	VANGUARD GROUP INC	3.93%	5.84M	17.8M	469.07K	+8.74%
Sep 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.14%	212.22K	647.27K	-53.83K	-20.23%
Sep 30, 2025	JANE STREET GROUP, LLC	0.15%	219.49K	669.46M	73.63K	+50.47%
Sep 30, 2025	J. SAFRA SARASIN HOLDING AG	0.15%	223.22K	680.82K	-158.22K	-41.48%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.16%	236.74K	722.05K	25.54K	+12.09%
Sep 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.43%	640.46K	1.95M	-215.11K	-25.14%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.53%	790.25K	2.41M	61.86K	+8.49%
Sep 30, 2025	SIRIOS CAPITAL MANAGEMENT L P	0.65%	970.2K	2.96M	-19.38K	-1.96%
Sep 30, 2025	DEUTSCHE BANK AG\	1.01%	1.5M	4.59M	992.9K	+194.14%
Sep 30, 2025	SPHERA FUNDS MANAGEMENT LTD.	1.21%	1.79M	5.47M	30K	+1.70%
Sep 30, 2025	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	3.54%	5.25M	16.01M	0	0
Sep 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.39%	572.64K	1.75M	147.92K	+34.83%
Sep 30, 2025	SUSQUEHANNA PORTFOLIO STRATEGIES, LLC	0.24%	353.74K	1.08M	146.03K	+70.30%
Sep 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.32%	475.93K	1.45M	-8.7K	-1.80%
Sep 30, 2025	STATE STREET CORP	1.38%	2.05M	6.25M	69.32K	+3.50%
Sep 30, 2025	TFG ASSET MANAGEMENT GP LTD	1.42%	2.11M	6.44M	-697.55K	-24.82%
Sep 30, 2025	AMERIPRISE FINANCIAL INC	1.48%	2.19M	6.69M	26.18K	+1.21%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.62%	2.41M	7.34M	775.78K	+47.58%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.64%	2.44M	7.43M	152.17K	+6.66%
Sep 30, 2025	REDMILE GROUP, LLC	4.25%	6.3M	19.22M	0	0
Sep 30, 2025	CANDRIAM S.C.A.	1.71%	2.53M	7.73M	0	0
Sep 30, 2025	OPALEYE MANAGEMENT INC.	1.75%	2.6M	7.93M	2.6M	+100.00%
Sep 30, 2025	WOODLINE PARTNERS LP	1.78%	2.64M	8.05M	1.58M	+150.38%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	1.9%	2.82M	8.61M	308.69K	+12.28%
Sep 30, 2025	BLACKROCK, INC.	5.33%	7.9M	24.09M	-63.36K	-0.80%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.01%	1.5M	4.58M	1.5M	+100.00%
Sep 30, 2025	MORGAN STANLEY	2.04%	3.03M	9.24M	2.2M	+263.93%
Sep 30, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.16%	243.76K	743.45K	182.06K	+295.12%
Sep 30, 2025	POINT72 EUROPE (LONDON) LLP	0.2%	302.86K	923.73K	96.06K	+46.45%
Sep 30, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.27%	405.95K	1.24M	1.76K	+0.44%
Sep 30, 2025	ACADIAN ASSET MANAGEMENT LLC	0.36%	532.36K	1.62M	63.15K	+13.46%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.51%	753.58K	2.3M	-24.32K	-3.13%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.52%	766.96K	2.34M	-122.91K	-13.81%
Sep 30, 2025	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.66%	980.29K	2.99M	-7.23K	-0.73%
Sep 30, 2025	MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	0.72%	1.07M	3.25M	-12.03K	-1.11%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.87%	1.3M	3.96M	1.3M	+100.00%
Sep 30, 2025	NORTHERN TRUST CORP	0.53%	787.71K	2.4M	44.48K	+5.99%
Sep 30, 2025	BVF INC/IL	4.72%	7M	21.35M	0	0
Sep 30, 2025	COASTAL BRIDGE ADVISORS, LLC	0.01%	17K	51.85K	0	0
Sep 30, 2025	WEALTH ENHANCEMENT ADVISORY SERVICES, LLC	0.01%	17.21K	52.82K	17.21K	+100.00%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.01%	18.22K	55.57K	18.22K	+100.00%
Sep 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.01%	19.32K	58.92K	-8.14K	-29.64%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.01%	19.74K	60.2K	9.76K	+97.81%
Sep 30, 2025	ENTRYPOINT CAPITAL, LLC	0.01%	19.97K	60.91K	19.97K	+100.00%
Sep 30, 2025	PROSHARE ADVISORS LLC	0.01%	20.29K	61.88K	-3.44K	-14.51%
Sep 30, 2025	MATAURO, LLC	0.01%	20.57K	62.75K	9.49K	+85.60%
Sep 30, 2025	CWM, LLC	0.02%	23.49K	72K	5.75K	+32.45%
Sep 30, 2025	HSBC HOLDINGS PLC	0.02%	25.72K	78.06K	-4.13K	-13.85%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.02%	26.68K	81.36K	-26.02K	-49.38%
Sep 30, 2025	FOREFRONT WEALTH PARTNERS, LLC	0.02%	27.03K	82.43K	27.03K	+100.00%
Sep 30, 2025	AXQ CAPITAL, LP	0.02%	27.87K	84.99K	27.87K	+100.00%
Sep 30, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.02%	28.11K	85.72K	7.52K	+36.52%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.02%	34.48K	105.16K	0	0
Sep 30, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	35.26K	107.55K	13.23K	+60.02%
Sep 30, 2025	GROUP ONE TRADING, L.P.	0.02%	35.57K	108.47M	35.57K	+100.00%
Sep 30, 2025	CITIZENS FINANCIAL GROUP INC/RI	0.03%	40K	122K	5K	+14.29%
Sep 30, 2025	ALLEGHENY FINANCIAL GROUP LTD	0.03%	42.9K	130.85K	0	0
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	44.63K	136.13K	-14.39K	-24.38%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.03%	46.85K	142.89K	0	0
Sep 30, 2025	JPMORGAN CHASE & CO	0.03%	46.89K	143K	-5.93K	-11.23%
Sep 30, 2025	ALPS ADVISORS INC	0.03%	47.88K	146.03K	-11.32K	-19.12%
Sep 30, 2025	DNB ASSET MANAGEMENT AS	0.06%	84.52K	257.8K	-15.05K	-15.12%
Sep 30, 2025	PARK AVENUE SECURITIES LLC	0.08%	113.07K	345K	0	0
Sep 30, 2025	RHUMBLINE ADVISERS	0.09%	132.6K	404.43K	-4.93K	-3.59%
Sep 30, 2025	BARCLAYS PLC	0.1%	147.93K	451.19K	-29.7K	-16.72%
Sep 30, 2025	INVESCO LTD.	0.14%	201.95K	615.93K	51.53K	+34.26%
Sep 30, 2025	UBS GROUP AG	0.23%	346.14K	1.06M	21.02K	+6.46%
Sep 30, 2025	BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY	0.33%	482.55K	1.47M	0	0
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.33%	484.78K	1.48M	-23.33K	-4.59%
Sep 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.39%	574.12K	1.75M	242.09K	+72.91%
Sep 30, 2025	NUVEEN, LLC	0.46%	682.56K	2.08M	426.64K	+166.71%
Sep 30, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.55%	823K	2.51M	363K	+78.91%
Sep 30, 2025	J. GOLDMAN & CO LP	0.75%	1.11M	3.38M	1.11M	+100.00%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.87%	1.29M	3.95M	-158.49K	-10.91%
Sep 30, 2025	BELLEVUE GROUP AG	3.48%	5.16M	15.73M	0	0
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.21%	308.19K	939.98K	7.14K	+2.37%
Sep 30, 2025	FMR LLC	7.47%	11.08M	33.8M	-4.61M	-29.40%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.28%	409.48K	1.25M	32.5K	+8.62%
Jun 30, 2025	MORGAN STANLEY	0.56%	832.54K	2B	131.18K	+18.70%
Jun 30, 2025	POINT72 ASIA (SINGAPORE) PTE. LTD.	0%	7.11K	17.07K	1.12K	+18.64%
Jun 30, 2025	HARBOR ADVISORS LLC	0.01%	10K	24K	0	0
Jun 30, 2025	CIBC WORLD MARKETS CORP	0.01%	11.8K	28.32K	-9.87K	-45.54%
Jun 30, 2025	49 WEALTH MANAGEMENT, LLC	0.01%	12.08K	29K	12.08K	+100.00%
Jun 30, 2025	COASTAL BRIDGE ADVISORS, LLC	0.01%	17K	40.8K	0	0
Jun 30, 2025	SIRIOS CAPITAL MANAGEMENT L P	0.67%	989.58K	2.37M	220.89K	+28.74%
Jun 30, 2025	SUSQUEHANNA PORTFOLIO STRATEGIES, LLC	0.14%	207.72K	498.52K	207.72K	+100.00%
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	0.14%	211.2K	506.87K	13K	+6.56%
Jun 30, 2025	ROYAL BANK OF CANADA	0.17%	245.2K	588K	238.37K	+3,487.93%
Jun 30, 2025		0.17%	255.92K	614.2K	-91.11K	-26.26%
Jun 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.17%	258.31K	48.62K	0	0
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.18%	266.05K	638.52K	154.85K	+139.25%
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.18%	266.81K	640.35K	67.59K	+33.93%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.2%	301.05K	722.52K	12.35K	+4.28%
Jun 30, 2025	UBS GROUP AG	0.22%	325.12K	780.29K	57.77K	+21.61%
Jun 30, 2025	WELLS FARGO & COMPANY/MN	0.25%	376.97K	904.74K	29.08K	+8.36%
Jun 30, 2025	J. SAFRA SARASIN HOLDING AG	0.26%	381.44K	915.46K	126.9K	+49.86%
Jun 30, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.27%	404.19K	970.07K	52.76K	+15.01%
Jun 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.29%	424.72K	1.02M	-312.55K	-42.39%
Jun 30, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.31%	460K	1.1M	0	0
Jun 30, 2025	BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY	0.33%	482.55K	1.16M	0	0
Jun 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.33%	484.63K	1.16M	7.07K	+1.48%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	1.7%	2.51M	6.03M	2.34M	+1,334.16%
Jun 30, 2025	SIO CAPITAL MANAGEMENT, LLC	2.77%	4.1M	9.83M	697.98K	+20.54%
Jun 30, 2025	BELLEVUE GROUP AG	3.48%	5.16M	12.38M	0	0
Jun 30, 2025	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	3.54%	5.25M	12.6M	0	0
Jun 30, 2025	VANGUARD GROUP INC	3.62%	5.37M	12.88M	-13.62K	-0.25%
Jun 30, 2025	REDMILE GROUP, LLC	4.25%	6.3M	15.12M	0	0
Jun 30, 2025	BVF INC/IL	4.73%	7M	16.8M	0	0
Jun 30, 2025	BLACKROCK, INC.	5.38%	7.96M	19.11M	-564.14K	-6.62%
Jun 30, 2025	FMR LLC	10.6%	15.7M	37.67M	2.43M	+18.34%
Jun 30, 2025	CITIZENS FINANCIAL GROUP INC/RI	0.02%	35K	84K	35K	+100.00%
Jun 30, 2025	WALLEYE CAPITAL LLC	0.54%	794.64K	1.91M	-8.27K	-1.03%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.49%	728.39K	1.75M	2.64K	+0.36%
Jun 30, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.01%	20.2K	48.47K	20.2K	+100.00%
Jun 30, 2025	QUADRATURE CAPITAL LTD	0.01%	20.52K	49.13K	2.78K	+15.69%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	1.1%	1.63M	3.91B	789.07K	+93.76%
Jun 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.39%	583.91K	1.4M	0	0
Jun 30, 2025	DEUTSCHE BANK AG\	0.35%	511.45K	1.23M	-25.85K	-4.81%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.34%	508.1K	1.22M	-16.64K	-3.17%
Jun 30, 2025	NORTHERN TRUST CORP	0.5%	743.22K	1.78M	-282.7K	-27.56%
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.53%	777.9K	1.87M	-384.54K	-33.08%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.6%	889.86K	2.14M	-97.02K	-9.83%
Jun 30, 2025	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.67%	987.51K	2.37M	-32.9K	-3.22%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.98%	1.45M	3.49M	414.07K	+39.86%
Jun 30, 2025	STATE STREET CORP	1.34%	1.98M	4.75M	-58.84K	-2.88%
Jun 30, 2025	ACADIAN ASSET MANAGEMENT LLC	0.32%	469.21K	1.13M	265.22K	+130.02%
Jun 30, 2025	TWO SIGMA INVESTMENTS, LP	0.14%	201.16K	482.78K	201.16K	+100.00%
Jun 30, 2025	QUARRY LP	0.03%	43.13K	103.52K	22.13K	+105.40%
Jun 30, 2025	TD ASSET MANAGEMENT INC	0.03%	46.85K	112.44K	0	0
Jun 30, 2025	ALLEGHENY FINANCIAL GROUP LTD	0.03%	42.9K	102.96K	17.7K	+70.24%
Jun 30, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0.04%	52.41K	125.77K	-4.86K	-8.48%
Jun 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.04%	52.7K	126.48K	-14.57K	-21.65%
Jun 30, 2025	BREVAN HOWARD CAPITAL MANAGEMENT LP	0.04%	53.28K	127.88K	-8.79K	-14.16%
Jun 30, 2025	ALPS ADVISORS INC	0.04%	59.2K	142.08K	-23.43K	-28.35%
Jun 30, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.04%	61.69K	148K	-121.6K	-66.34%
Jun 30, 2025	DNB ASSET MANAGEMENT AS	0.07%	99.57K	238.98K	25.2K	+33.87%
Jun 30, 2025	PARK AVENUE SECURITIES LLC	0.08%	113.07K	271K	30K	+36.12%
Jun 30, 2025	CINCTIVE CAPITAL MANAGEMENT LP	0.09%	135.47K	325.12K	0	0
Jun 30, 2025	IEQ CAPITAL, LLC	0.09%	135.8K	325.91K	55.8K	+69.75%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.1%	140.74K	337.78M	29.44K	+26.45%
Jun 30, 2025	POINT72 EUROPE (LONDON) LLP	0.14%	206.8K	496.32K	163.08K	+372.98%
Jun 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.22%	332.03K	796.88M	258.24K	+349.97%
Jun 30, 2025	VIRTUS INVESTMENT ADVISERS, INC.	0.02%	34.7K	83.28K	-1.7K	-4.67%
Jun 30, 2025	LIDO ADVISORS, LLC	0.02%	35K	84K	15K	+75.00%
Jun 30, 2025	MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	0.73%	1.08M	2.59M	48.28K	+4.68%
Jun 30, 2025	UBS OCONNOR LLC	0.33%	492.7K	1.18M	25.88K	+5.54%
Jun 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.58%	855.57K	2.05M	-19.15K	-2.19%
Jun 30, 2025	NUVEEN, LLC	0.17%	255.92K	614.2K	-91.11K	-26.26%
Jun 30, 2025	WOODLINE PARTNERS LP	0.71%	1.05M	2.53M	-1.06M	-50.17%
Jun 30, 2025	SPHERA FUNDS MANAGEMENT LTD.	1.19%	1.76M	4.23M	0	0
Jun 30, 2025	LOGOS GLOBAL MANAGEMENT LP	1.63%	2.41M	5.78M	-1.59M	-39.75%
Jun 30, 2025	CANDRIAM S.C.A.	1.71%	2.53M	6.08M	0	0
Jun 30, 2025	FOREFRONT ANALYTICS, LLC	0.02%	27.58K	66.18K	-1.02K	-3.55%
Jun 30, 2025	MARSHALL WACE, LLP	0.02%	29.99K	71.97K	29.99K	+100.00%
Jun 30, 2025	AMERIPRISE FINANCIAL INC	1.46%	2.17M	5.2M	-1.82M	-45.65%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.54%	2.28M	5.48M	39.76K	+1.77%
Jun 30, 2025	VIRTU FINANCIAL LLC	0.02%	30.6K	73K	30.6K	+100.00%
Jun 30, 2025	NATIXIS	0.05%	77.1K	185.04K	77.1K	+100.00%
Jun 30, 2025	TFG ASSET MANAGEMENT GP LTD	1.9%	2.81M	6.74M	160K	+6.04%
Mar 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.5%	737.27K	1.42M	275.9K	+59.80%
Mar 31, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.32%	477.57K	921.7K	47.98K	+11.17%
Mar 31, 2025	BVF INC/IL	4.73%	7M	13.51M	0	0
Mar 31, 2025	UBS GROUP AG	0.18%	267.35K	515.98K	-61.37K	-18.67%
Mar 31, 2025	MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	0.7%	1.03M	1.99M	1K	+0.10%
Mar 31, 2025	J. SAFRA SARASIN HOLDING AG	0.17%	254.54K	491.26K	98.79K	+63.43%
Mar 31, 2025	BLACKROCK, INC.	5.76%	8.53M	16.46M	40.32K	+0.48%
Mar 31, 2025	REDMILE GROUP, LLC	4.25%	6.3M	12.16M	0	0
Mar 31, 2025	SIO CAPITAL MANAGEMENT, LLC	2.29%	3.4M	6.56M	1.03M	+43.55%
Mar 31, 2025	TFG ASSET MANAGEMENT GP LTD	1.79%	2.65M	5.11M	1.25M	+89.29%
Mar 31, 2025	CANDRIAM S.C.A.	1.71%	2.53M	4.89M	0	0
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.52%	2.25M	4.33M	73.53K	+3.39%
Mar 31, 2025	WOODLINE PARTNERS LP	1.43%	2.11M	4.08M	-576.09K	-21.41%
Mar 31, 2025	SPHERA FUNDS MANAGEMENT LTD.	1.19%	1.76M	3.41M	521.35K	+41.94%
Mar 31, 2025	WELLS FARGO & COMPANY/MN	0.23%	347.89K	671.43K	112.14K	+47.57%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.19%	288.7K	557.19K	58.15K	+25.22%
Mar 31, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.12%	183.29K	354K	99.85K	+119.67%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.12%	175.3K	338.34K	19.63K	+12.61%
Mar 31, 2025	JPMORGAN CHASE & CO	0.97%	1.43M	2.76M	-79.55K	-5.26%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.78%	1.16M	2.24M	668.74K	+135.45%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.7%	1.04M	2M	1.01M	+3,369.35%
Mar 31, 2025	NORTHERN TRUST CORP	0.69%	1.03M	1.98M	-3.83K	-0.37%
Mar 31, 2025	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.69%	1.02M	1.97M	3.85K	+0.38%
Mar 31, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.39%	583.91K	1.13M	0	0
Mar 31, 2025	UBS OCONNOR LLC	0.32%	466.82K	900.96K	147.94K	+46.39%
Mar 31, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.31%	460K	887.8K	-82.5K	-15.21%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.24%	356.48K	688.01K	88.31K	+32.93%
Mar 31, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.24%	351.44K	678.27K	20.59K	+6.22%
Mar 31, 2025	FMR LLC	8.95%	13.26M	25.6M	-962.06K	-6.76%
Mar 31, 2025	WALLEYE CAPITAL LLC	0.54%	802.91K	1.55M	146.58K	+22.33%
Mar 31, 2025	VANGUARD GROUP INC	3.63%	5.38M	10.38M	-167.26K	-3.02%
Mar 31, 2025	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	3.54%	5.25M	10.13M	0	0
Mar 31, 2025	BELLEVUE GROUP AG	3.48%	5.16M	9.95M	0	0
Mar 31, 2025	LOGOS GLOBAL MANAGEMENT LP	2.7%	4M	7.72M	1.45M	+56.86%
Mar 31, 2025	AMERIPRISE FINANCIAL INC	2.69%	3.99M	7.69M	3.06M	+330.08%
Mar 31, 2025	DEUTSCHE BANK AG\	0.36%	537.29K	1.04M	791	+0.15%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.35%	524.74K	1.01M	-579.64K	-52.49%
Mar 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.17%	258.31K	104.32K	0	0
Mar 31, 2025	ACADIAN ASSET MANAGEMENT LLC	0.14%	203.99K	393K	48.35K	+31.06%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.13%	199.23K	384.5K	136.38K	+217.03%
Mar 31, 2025	AMERICAN CENTURY COMPANIES INC	0.13%	198.19K	382.52K	19.68K	+11.03%
Mar 31, 2025	BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY	0.33%	482.55K	931.32K	0	0
Mar 31, 2025	STATE STREET CORP	1.38%	2.04M	3.94M	-2.47M	-54.78%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.67%	986.88K	1.91M	-373.2K	-27.44%
Mar 31, 2025		0.23%	347.03K	669.77K	347.03K	+100.00%
Mar 31, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.59%	874.73K	1.69M	-217.11K	-19.88%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.57%	841.58K	1.62M	-475.43K	-36.10%
Mar 31, 2025	SIRIOS CAPITAL MANAGEMENT L P	0.52%	768.69K	1.48M	768.69K	+100.00%
Mar 31, 2025	MORGAN STANLEY	0.47%	701.36K	1.35M	56.68K	+8.79%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.49%	725.75K	1.4M	-18.04K	-2.43%
Mar 31, 2024	JUMP FINANCIAL, LLC	0.27%	210.2K	1.51M	210.2K	+100.00%
Mar 31, 2024	CITADEL ADVISORS LLC	0.33%	258.68K	1.85M	-799.01K	-75.54%
Mar 31, 2024	SOLEUS CAPITAL MANAGEMENT, L.P.	0.37%	292.4K	2.1M	-223K	-43.27%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.39%	308.06K	2.21M	113.46K	+58.30%
Mar 31, 2024	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.4%	315.16K	2.26M	-27.78K	-8.10%
Mar 31, 2024	MARSHALL WACE, LLP	0.4%	315.61K	2.26M	315.61K	+100.00%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	0.43%	333.91K	2.39M	246.87K	+283.60%
Mar 31, 2024	PARKMAN HEALTHCARE PARTNERS LLC	0.44%	346.69K	2.49M	346.69K	+100.00%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.48%	373.45K	2.68M	346.87K	+1,304.84%
Mar 31, 2024	BOOTHBAY FUND MANAGEMENT, LLC	0.48%	375.28K	2.69M	-332.54K	-46.98%
Mar 31, 2024	D. E. SHAW & CO., INC.	0.48%	379.25K	2.72M	379.25K	+100.00%
Mar 31, 2024	UBS OCONNOR LLC	0.32%	248.28K	1.78M	-444.65K	-64.17%
Mar 31, 2024	BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY	0.62%	482.55K	3.46M	0	0
Mar 31, 2024	CAPTION MANAGEMENT, LLC	0.51%	402.5K	2.89M	402.5K	+100.00%
Mar 31, 2024	NORTHERN TRUST CORP	0.71%	555.57K	3.98M	188.29K	+51.27%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.72%	562.97K	4.04M	278.03K	+97.58%
Mar 31, 2024	SCHONFELD STRATEGIC ADVISORS LLC	0.97%	761.6K	5.46M	744.6K	+4,380.00%
Mar 31, 2024	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.99%	773.91K	5.55M	-4.05K	-0.52%
Mar 31, 2024	KENNEDY CAPITAL MANAGEMENT LLC	0.99%	774.7K	5.55M	-301.03K	-27.98%
Mar 31, 2024	INVESCO LTD.	1.01%	789.04K	5.66M	767.27K	+3,524.12%
Mar 31, 2024	JPMORGAN CHASE & CO	1.23%	959.65K	6.88M	930.06K	+3,143.70%
Mar 31, 2024	POLAR CAPITAL HOLDINGS PLC	1.28%	1M	7.17M	1M	+100.00%
Mar 31, 2024	STATE STREET CORP	1.53%	1.2M	8.59M	351.85K	+41.58%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	1.63%	1.28M	9.16M	467.17K	+57.60%
Mar 31, 2024	PRICE T ROWE ASSOCIATES INC /MD/	1.69%	1.32M	9.49M	1.31M	+10,482.01%
Mar 31, 2024	IKARIAN CAPITAL, LLC	1.8%	1.41M	10.07M	-1.25M	-46.98%
Mar 31, 2024	FMR LLC	11.98%	9.37M	67.2M	-312.58K	-3.23%
Mar 31, 2024	MORGAN STANLEY	1.15%	899.51K	6.45M	707.45K	+368.35%
Mar 31, 2024	ACADIAN ASSET MANAGEMENT LLC	1.22%	957.99K	6.87M	83.97K	+9.61%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	1.83%	1.43M	10.25M	507.25K	+55.00%
Mar 31, 2024	PICTET ASSET MANAGEMENT HOLDING SA	2.1%	1.64M	11.79M	-158.56K	-8.79%
Mar 31, 2024	WOODLINE PARTNERS LP	2.56%	2M	14.34M	609	+0.03%
Mar 31, 2024	OCTAGON CAPITAL ADVISORS LP	2.62%	2.05M	14.7M	0	0
Mar 31, 2024	BELLEVUE GROUP AG	2.79%	2.18M	15.65M	2.18M	+100.00%
Mar 31, 2024	GMT CAPITAL CORP	3.38%	2.65M	18.97M	-374.95K	-12.41%
Mar 31, 2024	LOGOS GLOBAL MANAGEMENT LP	1.28%	1M	7.17M	1M	+100.00%
Mar 31, 2024	VANGUARD GROUP INC	4.79%	3.75M	26.87M	1.84M	+96.38%
Mar 31, 2024	ADAGE CAPITAL PARTNERS GP, L.L.C.	5.52%	4.32M	30.97M	-680K	-13.60%
Mar 31, 2024	BLACKROCK INC.	6.45%	5.04M	36.16M	1.72M	+51.98%
Mar 31, 2024	POINT72 ASSET MANAGEMENT, L.P.	6.59%	5.16M	36.97M	5.16M	+100.00%
Mar 31, 2024	REDMILE GROUP, LLC	7.04%	5.5M	39.46M	0	0
Mar 31, 2024	ALERCE INVESTMENT MANAGEMENT, L.P.	9.47%	7.41M	53.1M	0	0
Mar 31, 2024	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.75%	583.91K	4.19M	0	0
Mar 31, 2024	STEMPOINT CAPITAL LP	0.77%	605.12K	4.34M	-1.98K	-0.33%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.86%	671.2K	4.81M	187K	+38.62%
Mar 31, 2024	BVF INC/IL	8.95%	7M	50.19M	0	0
Mar 31, 2024	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	11.13%	8.7M	62.4M	641.55K	+7.96%
Mar 31, 2024	CITIGROUP INC	0.02%	12.88K	92.34K	5.83K	+82.58%
Mar 31, 2024	49 WEALTH MANAGEMENT, LLC	0.02%	13.29K	88.13K	-2.8K	-17.40%
Mar 31, 2024	ENTRYPOINT CAPITAL, LLC	0.02%	13.62K	97.64K	13.62K	+100.00%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.02%	14.81K	106.16K	14.81K	+100.00%
Mar 31, 2024	BELVEDERE TRADING LLC	0.02%	16.45K	117.92K	16.45K	+100.00%
Mar 31, 2024	ALLEGHENY FINANCIAL GROUP LTD	0.03%	21.7K	155.59K	0	0
Mar 31, 2024	SG AMERICAS SECURITIES, LLC	0.03%	21.7K	156K	-3.63K	-14.33%
Mar 31, 2024	AXQ CAPITAL, LP	0.03%	25.7K	184.27K	25.7K	+100.00%
Mar 31, 2024	GSA CAPITAL PARTNERS LLP	0.03%	25.71K	184K	25.71K	+100.00%
Mar 31, 2024	WELLS FARGO & COMPANY/MN	0.04%	28.91K	207.25K	12.47K	+75.91%
Mar 31, 2024	AMERICAN INTERNATIONAL GROUP, INC.	0.04%	33.2K	238.02K	10.51K	+46.33%
Mar 31, 2024	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.04%	33.57K	240.7K	33.57K	+100.00%
Mar 31, 2024	LINCOLN NATIONAL CORP	0.04%	35K	250.95K	35K	+100.00%
Mar 31, 2024	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	35.01K	251K	35.01K	+100.00%
Mar 31, 2024	DNB ASSET MANAGEMENT AS	0.05%	35.91K	257.48K	35.91K	+100.00%
Mar 31, 2024	PRUDENTIAL FINANCIAL INC	0.05%	37.13K	266.19K	-43.48K	-53.94%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.05%	40.62K	291.25K	0	0
Mar 31, 2024	CORNERCAP INVESTMENT COUNSEL INC	0.06%	46.7K	334.83K	0	0
Mar 31, 2024	SIMPLEX TRADING, LLC	0.08%	63.3K	453K	56.54K	+837.29%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.1%	78.42K	562.27K	44.56K	+131.57%
Mar 31, 2024	RHUMBLINE ADVISERS	0.1%	81.98K	587.77K	22.66K	+38.20%
Mar 31, 2024	UBS GROUP AG	0.12%	91.05K	652.8K	41.46K	+83.61%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.12%	93.81K	672.59K	73.79K	+368.54%
Mar 31, 2024	LIGHTHOUSE INVESTMENT PARTNERS, LLC	0.16%	122.78K	880.36K	55.27K	+81.87%
Mar 31, 2024	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.18%	141.04K	1.01M	52.95K	+60.10%
Mar 31, 2024	SUSQUEHANNA PORTFOLIO STRATEGIES, LLC	0.18%	141.56K	1.02M	141.56K	+100.00%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.09%	73.5K	527K	73.5K	+100.00%
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.23%	176.2K	1.26B	176.2K	+100.00%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.23%	180.62K	1.3M	46.34K	+34.51%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.23%	181.05K	1.3M	57.38K	+46.40%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.22%	922.23K	4.19M	42.62K	+4.84%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.07%	51.32K	233.01K	5.44K	+11.86%
Dec 31, 2023	RHUMBLINE ADVISERS	0.08%	59.32K	269.3K	-390	-0.65%
Dec 31, 2023	LIGHTHOUSE INVESTMENT PARTNERS, LLC	0.09%	67.51K	306.5K	67.51K	+100.00%
Dec 31, 2023	PRUDENTIAL FINANCIAL INC	0.11%	80.61K	365.95K	-92.2K	-53.35%
Dec 31, 2023	TWO SIGMA ADVISERS, LP	0.11%	84.8K	384.99K	-70.4K	-45.36%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	0.12%	87.05K	395.26K	28.53K	+48.74%
Dec 31, 2023	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.12%	88.09K	399.93K	-33.3K	-27.43%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.16%	123.67K	561.45K	0	0
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.18%	134.28K	609.62K	-20K	-12.96%
Dec 31, 2023	DEUTSCHE BANK AG\	0.21%	157K	712.79K	157K	+100.00%
Dec 31, 2023	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.24%	179.5K	814.93K	14.4K	+8.72%
Dec 31, 2023	BARCLAYS PLC	0.25%	185.33K	841K	149.6K	+418.68%
Dec 31, 2023	MORGAN STANLEY	0.25%	192.06K	871.95K	42.97K	+28.82%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.26%	194.6K	883.47K	6.46K	+3.43%
Dec 31, 2023	DRIEHAUS CAPITAL MANAGEMENT LLC	0.34%	258.31K	208.15K	0	0
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.38%	284.93K	1.29M	39.28K	+15.99%
Dec 31, 2023	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.46%	342.94K	1.56M	33.23K	+10.73%
Dec 31, 2023	NORTHERN TRUST CORP	0.49%	367.28K	1.67M	6.04K	+1.67%
Dec 31, 2023	WALLEYE CAPITAL LLC	0.5%	378.28K	1.72M	378.28K	+100.00%
Dec 31, 2023	SILVERARC CAPITAL MANAGEMENT, LLC	0.55%	417.43K	1.9M	17.71K	+4.43%
Dec 31, 2023	BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY	0.64%	482.55K	2.19M	-11.62K	-2.35%
Dec 31, 2023	RENAISSANCE TECHNOLOGIES LLC	0.64%	484.2K	2.2M	-77.11K	-13.74%
Dec 31, 2023	SOLEUS CAPITAL MANAGEMENT, L.P.	0.68%	515.4K	2.34M	0	0
Dec 31, 2023	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.78%	583.91K	2.65M	0	0
Dec 31, 2023	VONTOBEL HOLDING LTD.	0.86%	650.91K	2.96M	-247.87K	-27.58%
Dec 31, 2023	SECTORAL ASSET MANAGEMENT INC	0.86%	650.91K	2.96M	-247.87K	-27.58%
Dec 31, 2023	UBS OCONNOR LLC	0.92%	692.93K	3.15M	143.68K	+26.16%
Dec 31, 2023	BOOTHBAY FUND MANAGEMENT, LLC	0.94%	707.82K	3.21M	707.82K	+100.00%
Dec 31, 2023	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	1.03%	777.97K	3.53M	769	+0.10%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	1.08%	811.02K	3.68M	588.74K	+264.87%
Dec 31, 2023	STATE STREET CORP	1.12%	846.27K	3.84M	14.73K	+1.77%
Dec 31, 2023	ACADIAN ASSET MANAGEMENT LLC	1.16%	874.02K	3.97M	61.8K	+7.61%
Dec 31, 2023	CITADEL ADVISORS LLC	1.4%	1.06M	4.8M	372.73K	+54.42%
Dec 31, 2023	KENNEDY CAPITAL MANAGEMENT LLC	1.43%	1.08M	4.88M	98.74K	+10.11%
Dec 31, 2023		0.81%	607.1K	2.76M	607.1K	+100.00%
Dec 31, 2023	VANGUARD GROUP INC	2.53%	1.91M	8.66M	13.92K	+0.73%
Dec 31, 2023	WOODLINE PARTNERS LP	2.65%	2M	9.08M	535.64K	+36.58%
Dec 31, 2023	OCTAGON CAPITAL ADVISORS LP	2.72%	2.05M	9.31M	0	0
Dec 31, 2023	IKARIAN CAPITAL, LLC	3.52%	2.65M	12.03M	2.65M	+100.00%
Dec 31, 2023	GMT CAPITAL CORP	4.01%	3.02M	13.71M	210K	+7.47%
Dec 31, 2023	BLACKROCK INC.	4.4%	3.32M	15.07M	-89.41K	-2.62%
Dec 31, 2023	LOGOS GLOBAL MANAGEMENT LP	6.57%	4.95M	22.47M	-350K	-6.60%
Dec 31, 2023	ADAGE CAPITAL PARTNERS GP, L.L.C.	6.64%	5M	22.7M	2.65M	+112.77%
Dec 31, 2023	REDMILE GROUP, LLC	7.3%	5.5M	24.98M	2M	+57.09%
Dec 31, 2023	BVF INC/IL	9.29%	7M	31.78M	7M	+100.00%
Dec 31, 2023	ALERCE INVESTMENT MANAGEMENT, L.P.	9.83%	7.41M	33.62M	350K	+4.96%
Dec 31, 2023	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	10.7%	8.06M	36.6M	2.36M	+41.39%
Dec 31, 2023	FMR LLC	12.86%	9.69M	43.97M	9.59M	+10,452.61%
Sep 30, 2023	BLACKROCK INC.	4.53%	3.41M	-	-71.91K	-2.07%
Sep 30, 2023	HSBC HOLDINGS PLC	0.03%	19.26K	-	19.26K	+100.00%
Sep 30, 2023	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.03%	20.02K	-	0	0
Sep 30, 2023	KESTRA ADVISORY SERVICES, LLC	0.03%	21K	-	-4K	-16.00%
Sep 30, 2023	VOYA INVESTMENT MANAGEMENT LLC	0.03%	21.48K	-	2.71K	+14.43%
Sep 30, 2023	ALLEGHENY FINANCIAL GROUP LTD	0.03%	21.7K	-	21.7K	+100.00%
Sep 30, 2023	SG AMERICAS SECURITIES, LLC	0.03%	22.21K	-	22.21K	+100.00%
Sep 30, 2023	AMERICAN INTERNATIONAL GROUP, INC.	0.03%	22.78K	-	810	+3.69%
Sep 30, 2023	AMERICAN CENTURY COMPANIES INC	0.03%	24.17K	-	5.04K	+26.35%
Sep 30, 2023	UBS GROUP AG	0.03%	24.65K	-	-2.28K	-8.47%
Sep 30, 2023	FOREFRONT ANALYTICS, LLC	0.04%	31.68K	-	4.89K	+18.25%
Sep 30, 2023	BARCLAYS PLC	0.05%	35.73K	-	-2.99K	-7.73%
Sep 30, 2023	TWO SIGMA INVESTMENTS, LP	0.05%	37.1K	-	-201.2K	-84.43%
Sep 30, 2023	ALLIANCEBERNSTEIN L.P.	0.05%	40.62K	-	0	0
Sep 30, 2023	PARALLAX VOLATILITY ADVISERS, L.P.	0.06%	41.54K	-	41.54K	+100.00%
Sep 30, 2023	ALGERT GLOBAL LLC	0.06%	41.66K	-	3K	+7.76%
Sep 30, 2023	CORNERCAP INVESTMENT COUNSEL INC	0.06%	46.7K	-	-563	-1.19%
Sep 30, 2023	DIMENSIONAL FUND ADVISORS LP	0.08%	58.52K	-	16	+0.03%
Sep 30, 2023	RHUMBLINE ADVISERS	0.08%	59.71K	-	4.68K	+8.50%
Sep 30, 2023	FMR LLC	0.12%	91.78K	-	-1.31M	-93.47%
Sep 30, 2023	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.16%	121.39K	-	-20.33K	-14.35%
Sep 30, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.16%	123.67K	-	0	0
Sep 30, 2023	SCHONFELD STRATEGIC ADVISORS LLC	0.2%	147.35K	-	124.85K	+554.87%
Sep 30, 2023	MORGAN STANLEY	0.2%	149.09K	-	41.76K	+38.90%
Sep 30, 2023	BANK OF NEW YORK MELLON CORP	0.21%	154.28K	-	0	0
Sep 30, 2023	TWO SIGMA ADVISERS, LP	0.21%	155.2K	-	-94.9K	-37.94%
Sep 30, 2023	PRUDENTIAL FINANCIAL INC	0.23%	172.81K	-	172.81K	+100.00%
Sep 30, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.25%	188.14K	-	0	0
Sep 30, 2023	GOLDMAN SACHS GROUP INC	0.33%	245.66K	-	158.25K	+181.05%
Sep 30, 2023	DRIEHAUS CAPITAL MANAGEMENT LLC	0.34%	258.31K	-	-494.2K	-65.67%
Sep 30, 2023	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.41%	309.71K	-	-29.39K	-8.67%
Sep 30, 2023	NORTHERN TRUST CORP	0.48%	361.24K	-	-17.96K	-4.74%
Sep 30, 2023	SILVERARC CAPITAL MANAGEMENT, LLC	0.53%	399.72K	-	9.81K	+2.51%
Sep 30, 2023	VELAN CAPITAL INVESTMENT MANAGEMENT LP	0.61%	459.75K	-	0	0
Sep 30, 2023	ALERCE INVESTMENT MANAGEMENT, L.P.	9.38%	7.06M	-	0	0
Sep 30, 2023	FEDERATED HERMES, INC.	0.64%	485.05K	-	-2.57M	-84.14%
Sep 30, 2023	SIMPLIFY ASSET MANAGEMENT INC.	0.65%	492.6K	-	-160.89K	-24.62%
Sep 30, 2023	BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY	0.66%	494.17K	-	11.62K	+2.41%
Sep 30, 2023	SOLEUS CAPITAL MANAGEMENT, L.P.	0.69%	515.4K	-	-105K	-16.92%
Sep 30, 2023	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.78%	583.91K	-	0	0
Sep 30, 2023	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	1.03%	777.2K	-	1.35K	+0.17%
Sep 30, 2023	ACADIAN ASSET MANAGEMENT LLC	1.08%	812.22K	-	-8.34K	-1.02%
Sep 30, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.17%	879.62K	-	-3.89K	-0.44%
Sep 30, 2023	VONTOBEL HOLDING LTD.	1.19%	898.79K	-	224.16K	+33.23%
Sep 30, 2023	SECTORAL ASSET MANAGEMENT INC	1.19%	898.79K	-	224.16K	+33.23%
Sep 30, 2023	BLACKSTONE INC.	1.21%	910.49K	-	0	0
Sep 30, 2023	KENNEDY CAPITAL MANAGEMENT LLC	1.3%	976.99K	-	976.99K	+100.00%
Sep 30, 2023	WOODLINE PARTNERS LP	1.95%	1.46M	-	759.74K	+107.82%
Sep 30, 2023		2.4%	1.8M	-	1.8M	+100.00%
Sep 30, 2023	GMT CAPITAL CORP	3.74%	2.81M	-	345.9K	+14.03%

Insiders

Among the ANNX insiders holding of 0.33% of the stake in company, SATTER MUNEER A, director, holds the largest shares of 9.73M. BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC, 10 percent owner, is the second largest ANNX insider with ownership of 5.7M shares. CLARUS LIFESCIENCES III, L.P., 10 percent owner, stands third with possession of 2.73M shares of that stake.

Insiders	Designation	Shares Held
SATTER MUNEER A	director	9.73M
BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	10 percent owner	5.7M
CLARUS LIFESCIENCES III, L.P.	10 percent owner	2.73M
FLYNN JAMES E	10 percent owner	808.91K
LOVE DOUGLAS	PRESIDENT AND CEO	351.55K
OVERDORF MICHAEL	EVP & CHIEF BUSINESS OFFICER	130.69K
LEW JENNIFER	EVP & CHIEF FINANCIAL OFFICER	121.62K
YEDNOCK TED	EVP & CHIEF INNOVATION OFFICER	105.08K
ARTIS DEAN RICHARD	EVP & CHIEF SCIENTIFIC OFFICER	83.81K
CARSON WILLIAM H.	director	54.41K
DANANBERG JAMIE	CHIEF MEDICAL OFFICER	33.48K
CHOI JUNG	director	33K
KESWANI SANJAY	EVP & Chief Medical Officer	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Dec 30, 2025	CARSON WILLIAM H.	PURCHASE	5.02	4.12K	20.66K	54.41K
Dec 01, 2025	CARSON WILLIAM H.	PURCHASE	4.47	4.12K	18.39K	50.29K
Dec 01, 2025	CHOI JUNG	PURCHASE	4.19	33K	138.27K	33K
Nov 21, 2025	SATTER MUNEER A	PURCHASE	4.28	422.61K	1.81M	9.73M
Nov 20, 2025	SATTER MUNEER A	PURCHASE	4.48	400K	1.79M	9.31M
Nov 19, 2025	SATTER MUNEER A	PURCHASE	3.94	500K	1.97M	8.91M
Nov 18, 2025	SATTER MUNEER A	PURCHASE	3.18	500K	1.59M	8.41M
Nov 17, 2025	SATTER MUNEER A	PURCHASE	2.99	500K	1.5M	7.91M
Oct 30, 2025	CARSON WILLIAM H.	PURCHASE	3.17	4.12K	13.04K	46.18K
Sep 30, 2025	CARSON WILLIAM H.	PURCHASE	3.05	4.12K	12.55K	42.06K
Sep 02, 2025	CARSON WILLIAM H.	PURCHASE	2.09	4.12K	8.6K	37.95K
Jul 30, 2025	CARSON WILLIAM H.	PURCHASE	2.43	4.12K	10K	33.83K
Jul 14, 2025	OVERDORF MICHAEL	SALE	2.61	853	2.23K	130.69K
Jul 14, 2025	YEDNOCK TED	SALE	2.58	1.12K	2.88K	105.08K
Jul 14, 2025	LEW JENNIFER	SALE	2.58	1.12K	2.88K	121.62K
Jun 30, 2025	CARSON WILLIAM H.	PURCHASE	2.46	4.12K	10.12K	29.72K
Feb 18, 2025	LEW JENNIFER	SALE	2.92	6.91K	20.18K	77.77K
Feb 18, 2025	YEDNOCK TED	SALE	2.91	8.35K	24.28K	61.24K
Feb 18, 2025	ARTIS DEAN RICHARD	SALE	2.97	5.52K	16.38K	83.81K
Feb 18, 2025	DANANBERG JAMIE	SALE	2.96	5.52K	16.34K	33.48K
Feb 18, 2025	OVERDORF MICHAEL	SALE	2.95	6.62K	19.52K	86.58K
Feb 13, 2025	YEDNOCK TED	SALE	2.99	1.78K	5.33K	69.58K
Feb 13, 2025	LOVE DOUGLAS	SALE	2.95	5.02K	14.81K	351.55K
Feb 13, 2025	OVERDORF MICHAEL	SALE	2.99	1.43K	4.26K	93.2K
Feb 13, 2025	LEW JENNIFER	SALE	2.98	1.79K	5.32K	84.68K
Dec 02, 2024	CARSON WILLIAM H.	PURCHASE	5.33	3.2K	17.06K	25.6K
Oct 15, 2024	YEDNOCK TED	SALE	7.41	5.41K	40.07K	71.37K
Oct 01, 2024	CARSON WILLIAM H.	PURCHASE	5.97	3.2K	19.1K	22.4K
Sep 19, 2024	YEDNOCK TED	SALE	7.10	4.5K	31.95K	0
Sep 12, 2024	YEDNOCK TED	SALE	6.16	5.5K	33.88K	4.5K
Sep 05, 2024	YEDNOCK TED	SALE	5.64	5.5K	31.02K	10K
Sep 03, 2024	CARSON WILLIAM H.	PURCHASE	5.48	3.2K	17.54K	19.2K
Aug 29, 2024	YEDNOCK TED	SALE	5.95	5.5K	32.73K	15.5K
Aug 01, 2024	CARSON WILLIAM H.	PURCHASE	6.24	3.2K	19.97K	16K
Jul 15, 2024	LEW JENNIFER	SALE	6.03	1.1K	6.66K	86.47K
Jul 15, 2024	YEDNOCK TED	SALE	6.02	1.11K	6.66K	71.37K
Jul 15, 2024	OVERDORF MICHAEL	SALE	6.02	784	4.72K	94.62K
Jul 01, 2024	CARSON WILLIAM H.	PURCHASE	5.00	3.2K	16K	12.8K
Jun 03, 2024	CARSON WILLIAM H.	PURCHASE	4.83	3.2K	15.46K	9.6K
May 01, 2024	CARSON WILLIAM H.	PURCHASE	4.68	3.2K	14.98K	6.4K
Apr 08, 2024	CARSON WILLIAM H.	PURCHASE	6.07	3.2K	19.41K	3.2K
Feb 20, 2024	OVERDORF MICHAEL	SALE	5.48	1.95K	10.69K	85.64K
Feb 20, 2024	LEW JENNIFER	SALE	5.53	2.59K	14.34K	82.06K
Feb 20, 2024	YEDNOCK TED	SALE	5.51	2.6K	14.35K	72.47K
Feb 12, 2024	YEDNOCK TED	SALE	5.54	1.81K	10.03K	36.08K
Feb 12, 2024	LOVE DOUGLAS	SALE	5.54	5.78K	32.03K	196.12K
Feb 12, 2024	OVERDORF MICHAEL	SALE	5.53	1.35K	7.46K	48.59K
Feb 12, 2024	LEW JENNIFER	SALE	5.54	1.81K	10.02K	45.65K
Dec 27, 2023	YEDNOCK TED	SALE	4.52	21K	94.97K	0
Dec 26, 2023	SATTER MUNEER A	PURCHASE	2.88	350K	1.01M	7.41M
Jul 11, 2023	YEDNOCK TED	SALE	3.84	1.06K	4.05K	37.89K
Jul 11, 2023	LEW JENNIFER	SALE	3.84	1.06K	4.05K	47.46K
Jul 11, 2023	OVERDORF MICHAEL	SALE	3.84	978	3.75K	45.8K
May 25, 2023	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	PURCHASE	2.13	300K	639.72K	5.7M
Feb 15, 2023	LOVE DOUGLAS	SALE	5.87	6.57K	38.56K	197.65K
Feb 14, 2023	LEW JENNIFER	SALE	6.30	166	1.05K	29.54K
Feb 14, 2023	OVERDORF MICHAEL	SALE	6.30	144	907.1	27.81K
Feb 13, 2023	OVERDORF MICHAEL	SALE	6.30	1.5K	9.46K	27.95K
Feb 13, 2023	LEW JENNIFER	SALE	6.31	1.74K	10.99K	29.71K
Feb 10, 2023	SATTER MUNEER A	PURCHASE	6.80	2.65M	18M	7.06M
Jul 07, 2022	SATTER MUNEER A	PURCHASE	0.13	613.5K	76.69K	613.5K
Apr 14, 2022	LOVE DOUGLAS	PURCHASE	2.45	60K	146.81K	200.94K
Sep 16, 2021	LOVE DOUGLAS	SALE	22.05	7.5K	165.34K	0
Sep 13, 2021	YEDNOCK TED	SALE	20.00	16.19K	323.86K	0
Sep 13, 2021	LEW JENNIFER	SALE	20.01	3.5K	70.03K	2K
Jun 08, 2021	LOVE DOUGLAS	SALE	22.55	3.75K	84.56K	0
Jun 07, 2021	LOVE DOUGLAS	SALE	22.31	3.75K	83.67K	0
Jun 03, 2021	YEDNOCK TED	SALE	21.72	2.18K	47.44K	0
May 27, 2021	LEW JENNIFER	SALE	22.24	3.5K	77.84K	2K
Apr 01, 2021	LOVE DOUGLAS	SALE	28.01	300	8.4K	0
Mar 31, 2021	LOVE DOUGLAS	SALE	28.11	7.1K	199.62K	0
Mar 30, 2021	LOVE DOUGLAS	SALE	24.78	1.85K	45.85K	0
Mar 29, 2021	LOVE DOUGLAS	SALE	27.24	300	8.17K	0
Mar 25, 2021	YEDNOCK TED	SALE	29.96	237	7.1K	0
Mar 24, 2021	KESWANI SANJAY	SALE	30.17	4K	120.51K	0
Mar 23, 2021	LEW JENNIFER	SALE	29.16	1.8K	52.49K	2K
Jul 28, 2020	SATTER MUNEER A	PURCHASE	17.00	200K	3.4M	1.95M
Jul 28, 2020	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	PURCHASE	17.00	400K	6.8M	3.24M
Jul 28, 2020	CLARUS LIFESCIENCES III, L.P.	PURCHASE	17.00	200K	3.4M	2.73M
Jul 28, 2020	LEW JENNIFER	PURCHASE	17.00	2K	34K	2K
Jul 28, 2020	FLYNN JAMES E	PURCHASE	17.00	350K	5.95M	808.91K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE2.38M11

SALES00

NET SHARES2.38M11

SHARES HELD44.52M11

% NET SHARES-94.66%0%

Frequently Asked Questions

Stock Outstanding Shares

ShortableYes

OptionableYes

Short Percent Of Outstanding Shares11.55

Short Percent Of Float13.54

Shares Outstanding149.06M

Shares Float111.26M

Shares Short17.22M

Short Ratio6.63

13.54%

Short % of Float

11.55%

Short % of Shares Outstanding

Market Insider

Investors cannot turn a blind eye to insiders as well as institutional ownership. They need to follow insider trades to determine the direction the stock is likely to take.

Major Holders Summary

0.33% Percentage of Shares held by All Insiders

79.2% Percentage of Shares held by All Institutions

79.46% Percentage of Float held by Institutions

191

Number of Institutions Holding Shares

Institutional Ownership

Date	Holder	% Stake	Shares Held	Total Value ($)	Shares	% Change in Portfolio
Dec 31, 2025	MARSHALL WACE, LLP	0.35%	521K	2.62M	521K	+100.00%
Dec 31, 2025	UBS GROUP AG	0.25%	377.1K	1.89B	30.97K	+8.95%
Dec 31, 2025	BANK OF NEW YORK MELLON CORP	0.24%	361.68K	1.82M	53.49K	+17.36%
Dec 31, 2025	TWO SIGMA INVESTMENTS, LP	0.22%	332.04K	1.67B	52.9K	+18.95%
Dec 31, 2025	CAPTRUST FINANCIAL ADVISORS	0.02%	31.59K	158.56K	31.59K	+100.00%
Dec 31, 2025	BARCLAYS PLC	0.19%	289.96K	1.46B	142.03K	+96.01%
Dec 31, 2025	DAFNA CAPITAL MANAGEMENT LLC	0.18%	272.81K	1.37M	272.81K	+100.00%
Dec 31, 2025	XTX TOPCO LTD	0.16%	243.31K	1.22B	95.47K	+64.58%
Dec 31, 2025	IEQ CAPITAL, LLC	0.12%	182.98K	918.57K	32.66K	+21.73%
Dec 31, 2025	ADVISOR GROUP HOLDINGS, INC.	0.1%	147.38K	739.82M	0	0
Dec 31, 2025	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.09%	137.8K	691.76M	0	0
Dec 31, 2025	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.09%	130.1K	655.09K	-2.57K	-1.94%
Dec 31, 2025	RHUMBLINE ADVISERS	0.08%	126.46K	634.83M	-6.14K	-4.63%
Dec 31, 2025	JUMP FINANCIAL, LLC	0.08%	122.86K	616.75K	122.86K	+100.00%
Dec 31, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.36%	534.99K	2.69M	59.06K	+12.41%
Dec 31, 2025	CITIZENS FINANCIAL GROUP INC/RI	0.03%	40K	200.8K	0	0
Dec 31, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	39.06K	196.08K	-5.57K	-12.49%
Dec 31, 2025	COMERICA BANK	0.02%	32.36K	162.43K	0	0
Dec 31, 2025	MARINER, LLC	0.02%	31.34K	157.35K	31.34K	+100.00%
Dec 31, 2025	CWM, LLC	0.02%	30.3K	152K	6.81K	+28.99%
Dec 31, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.02%	29.57K	148.43K	-4.91K	-14.24%
Dec 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.71%	1.06M	5.31M	266.81K	+33.76%
Dec 31, 2025	AXQ CAPITAL, LP	0.02%	29.11K	146.12K	1.24K	+4.45%
Dec 31, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.02%	28.11K	141.09K	0	0
Dec 31, 2025	SG AMERICAS SECURITIES, LLC	0.02%	28.07K	141K	17.07K	+155.26%
Dec 31, 2025	PROSHARE ADVISORS LLC	0.02%	24.7K	123.98K	4.41K	+21.74%
Dec 31, 2025	CITIGROUP INC	0.02%	23.64K	118.67K	16.81K	+246.22%
Dec 31, 2025	DNB ASSET MANAGEMENT AS	0.08%	118.32K	593.99K	33.8K	+39.99%
Dec 31, 2025	J. SAFRA SARASIN HOLDING AG	0.08%	117.77K	591.2K	-105.45K	-47.24%
Dec 31, 2025	CITADEL ADVISORS LLC	0.05%	70.4K	353.41M	9.2K	+15.03%
Dec 31, 2025	BNP PARIBAS ARBITRAGE, SNC	0.04%	61.57K	309.09M	41.83K	+211.93%
Dec 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.95%	2.9M	14.58B	465.95K	+19.12%
Dec 31, 2025	MORGAN STANLEY	1.92%	2.86M	14.34B	-173.71K	-5.73%
Dec 31, 2025	TFG ASSET MANAGEMENT GP LTD	1.36%	2.03M	10.2M	-80K	-3.79%
Dec 31, 2025	ALLEGHENY FINANCIAL GROUP LTD	0.03%	42.9K	215.36K	0	0
Dec 31, 2025	ENTRYPOINT CAPITAL, LLC	0.03%	42.77K	214.73K	22.8K	+114.18%
Dec 31, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.03%	42.52K	213.47K	15.85K	+59.41%
Dec 31, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	36.08K	181.14K	823	+2.33%
Dec 31, 2025	LIDO ADVISORS, LLC	0.02%	34.95K	106.6K	0	0
Dec 31, 2025	LANDING POINT FINANCIAL GROUP, LLC	0.02%	34.9K	175.2K	34.9K	+100.00%
Dec 31, 2025	SEI INVESTMENTS CO	0.04%	58.26K	292.46K	58.26K	+100.00%
Dec 31, 2025	JPMORGAN CHASE & CO	0.04%	53.73K	269.72K	6.84K	+14.60%
Dec 31, 2025	VIRTUS INVESTMENT ADVISERS, INC.	0.04%	53.53K	268.71K	11.54K	+27.48%
Dec 31, 2025	WINTON GROUP LTD	0.04%	53.4K	268.07K	53.4K	+100.00%
Dec 31, 2025	PROFUND ADVISORS LLC	0.04%	53.01K	266.1K	53.01K	+100.00%
Dec 31, 2025	JANE STREET GROUP, LLC	0.04%	52.9K	265.56M	40.8K	+337.19%
Dec 31, 2025	TD ASSET MANAGEMENT INC	0.03%	46.85K	235.18K	0	0
Dec 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.03%	44.8K	224.9M	28.7K	+178.26%
Dec 31, 2025	STATE STREET CORP	3.12%	4.65M	23.35M	2.6M	+126.90%
Dec 31, 2025	NUVEEN, LLC	1.96%	2.92M	14.63B	2.23M	+327.12%
Dec 31, 2025	GOLDMAN SACHS GROUP INC	1.19%	1.77M	8.88B	-637.69K	-26.50%
Dec 31, 2025	MILLENNIUM MANAGEMENT LLC	1.9%	2.84M	14.24B	14.03K	+0.50%
Dec 31, 2025	VANGUARD GROUP INC	5.2%	7.75M	38.92B	1.92M	+32.87%
Dec 31, 2025	BLACKROCK, INC.	6.01%	8.96M	44.98B	1.06M	+13.44%
Dec 31, 2025	BANK OF AMERICA CORP /DE/	1.08%	1.61M	8.06B	311.28K	+24.05%
Dec 31, 2025	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.61%	903.44K	4.54M	-76.85K	-7.84%
Dec 31, 2025	ACADIAN ASSET MANAGEMENT LLC	0.58%	861.25K	4.32M	328.88K	+61.78%
Dec 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.54%	802.6K	4.03B	49.02K	+6.51%
Dec 31, 2025	AQR CAPITAL MANAGEMENT LLC	0.52%	776.31K	3.9M	202.18K	+35.22%
Dec 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.48%	718.68K	3.61M	-48.28K	-6.29%
Dec 31, 2025	MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	0.43%	642.04K	3.22M	-424.89K	-39.82%
Dec 31, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.4%	601.2K	3.02M	195.25K	+48.10%
Dec 31, 2025	WELLS FARGO & COMPANY/MN	0.38%	573.75K	2.88M	164.27K	+40.12%
Dec 31, 2025	DEUTSCHE BANK AG\	0.38%	560.74K	2.81M	-943.61K	-62.73%
Sep 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.39%	583.91K	1.78M	0	0
Sep 30, 2025	SUMMITTX CAPITAL, L.P.	0.16%	241.99K	738.07K	241.99K	+100.00%
Sep 30, 2025	TWO SIGMA INVESTMENTS, LP	0.19%	279.13K	851.36K	77.97K	+38.76%
Sep 30, 2025	ROYAL BANK OF CANADA	0.19%	285.85K	871K	40.65K	+16.58%
Sep 30, 2025	VANGUARD GROUP INC	3.93%	5.84M	17.8M	469.07K	+8.74%
Sep 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.14%	212.22K	647.27K	-53.83K	-20.23%
Sep 30, 2025	JANE STREET GROUP, LLC	0.15%	219.49K	669.46M	73.63K	+50.47%
Sep 30, 2025	J. SAFRA SARASIN HOLDING AG	0.15%	223.22K	680.82K	-158.22K	-41.48%
Sep 30, 2025	AMERICAN CENTURY COMPANIES INC	0.16%	236.74K	722.05K	25.54K	+12.09%
Sep 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.43%	640.46K	1.95M	-215.11K	-25.14%
Sep 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.53%	790.25K	2.41M	61.86K	+8.49%
Sep 30, 2025	SIRIOS CAPITAL MANAGEMENT L P	0.65%	970.2K	2.96M	-19.38K	-1.96%
Sep 30, 2025	DEUTSCHE BANK AG\	1.01%	1.5M	4.59M	992.9K	+194.14%
Sep 30, 2025	SPHERA FUNDS MANAGEMENT LTD.	1.21%	1.79M	5.47M	30K	+1.70%
Sep 30, 2025	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	3.54%	5.25M	16.01M	0	0
Sep 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.39%	572.64K	1.75M	147.92K	+34.83%
Sep 30, 2025	SUSQUEHANNA PORTFOLIO STRATEGIES, LLC	0.24%	353.74K	1.08M	146.03K	+70.30%
Sep 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.32%	475.93K	1.45M	-8.7K	-1.80%
Sep 30, 2025	STATE STREET CORP	1.38%	2.05M	6.25M	69.32K	+3.50%
Sep 30, 2025	TFG ASSET MANAGEMENT GP LTD	1.42%	2.11M	6.44M	-697.55K	-24.82%
Sep 30, 2025	AMERIPRISE FINANCIAL INC	1.48%	2.19M	6.69M	26.18K	+1.21%
Sep 30, 2025	GOLDMAN SACHS GROUP INC	1.62%	2.41M	7.34M	775.78K	+47.58%
Sep 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.64%	2.44M	7.43M	152.17K	+6.66%
Sep 30, 2025	REDMILE GROUP, LLC	4.25%	6.3M	19.22M	0	0
Sep 30, 2025	CANDRIAM S.C.A.	1.71%	2.53M	7.73M	0	0
Sep 30, 2025	OPALEYE MANAGEMENT INC.	1.75%	2.6M	7.93M	2.6M	+100.00%
Sep 30, 2025	WOODLINE PARTNERS LP	1.78%	2.64M	8.05M	1.58M	+150.38%
Sep 30, 2025	MILLENNIUM MANAGEMENT LLC	1.9%	2.82M	8.61M	308.69K	+12.28%
Sep 30, 2025	BLACKROCK, INC.	5.33%	7.9M	24.09M	-63.36K	-0.80%
Sep 30, 2025	ADAGE CAPITAL PARTNERS GP, L.L.C.	1.01%	1.5M	4.58M	1.5M	+100.00%
Sep 30, 2025	MORGAN STANLEY	2.04%	3.03M	9.24M	2.2M	+263.93%
Sep 30, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.16%	243.76K	743.45K	182.06K	+295.12%
Sep 30, 2025	POINT72 EUROPE (LONDON) LLP	0.2%	302.86K	923.73K	96.06K	+46.45%
Sep 30, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.27%	405.95K	1.24M	1.76K	+0.44%
Sep 30, 2025	ACADIAN ASSET MANAGEMENT LLC	0.36%	532.36K	1.62M	63.15K	+13.46%
Sep 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.51%	753.58K	2.3M	-24.32K	-3.13%
Sep 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.52%	766.96K	2.34M	-122.91K	-13.81%
Sep 30, 2025	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.66%	980.29K	2.99M	-7.23K	-0.73%
Sep 30, 2025	MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	0.72%	1.07M	3.25M	-12.03K	-1.11%
Sep 30, 2025	BALYASNY ASSET MANAGEMENT L.P.	0.87%	1.3M	3.96M	1.3M	+100.00%
Sep 30, 2025	NORTHERN TRUST CORP	0.53%	787.71K	2.4M	44.48K	+5.99%
Sep 30, 2025	BVF INC/IL	4.72%	7M	21.35M	0	0
Sep 30, 2025	COASTAL BRIDGE ADVISORS, LLC	0.01%	17K	51.85K	0	0
Sep 30, 2025	WEALTH ENHANCEMENT ADVISORY SERVICES, LLC	0.01%	17.21K	52.82K	17.21K	+100.00%
Sep 30, 2025	RUSSELL INVESTMENTS GROUP, LTD.	0.01%	18.22K	55.57K	18.22K	+100.00%
Sep 30, 2025	VOYA INVESTMENT MANAGEMENT LLC	0.01%	19.32K	58.92K	-8.14K	-29.64%
Sep 30, 2025	BNP PARIBAS ARBITRAGE, SNC	0.01%	19.74K	60.2K	9.76K	+97.81%
Sep 30, 2025	ENTRYPOINT CAPITAL, LLC	0.01%	19.97K	60.91K	19.97K	+100.00%
Sep 30, 2025	PROSHARE ADVISORS LLC	0.01%	20.29K	61.88K	-3.44K	-14.51%
Sep 30, 2025	MATAURO, LLC	0.01%	20.57K	62.75K	9.49K	+85.60%
Sep 30, 2025	CWM, LLC	0.02%	23.49K	72K	5.75K	+32.45%
Sep 30, 2025	HSBC HOLDINGS PLC	0.02%	25.72K	78.06K	-4.13K	-13.85%
Sep 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.02%	26.68K	81.36K	-26.02K	-49.38%
Sep 30, 2025	FOREFRONT WEALTH PARTNERS, LLC	0.02%	27.03K	82.43K	27.03K	+100.00%
Sep 30, 2025	AXQ CAPITAL, LP	0.02%	27.87K	84.99K	27.87K	+100.00%
Sep 30, 2025	POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY	0.02%	28.11K	85.72K	7.52K	+36.52%
Sep 30, 2025	NEW YORK STATE COMMON RETIREMENT FUND	0.02%	34.48K	105.16K	0	0
Sep 30, 2025	CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD.	0.02%	35.26K	107.55K	13.23K	+60.02%
Sep 30, 2025	GROUP ONE TRADING, L.P.	0.02%	35.57K	108.47M	35.57K	+100.00%
Sep 30, 2025	CITIZENS FINANCIAL GROUP INC/RI	0.03%	40K	122K	5K	+14.29%
Sep 30, 2025	ALLEGHENY FINANCIAL GROUP LTD	0.03%	42.9K	130.85K	0	0
Sep 30, 2025	METLIFE INVESTMENT MANAGEMENT, LLC	0.03%	44.63K	136.13K	-14.39K	-24.38%
Sep 30, 2025	TD ASSET MANAGEMENT INC	0.03%	46.85K	142.89K	0	0
Sep 30, 2025	JPMORGAN CHASE & CO	0.03%	46.89K	143K	-5.93K	-11.23%
Sep 30, 2025	ALPS ADVISORS INC	0.03%	47.88K	146.03K	-11.32K	-19.12%
Sep 30, 2025	DNB ASSET MANAGEMENT AS	0.06%	84.52K	257.8K	-15.05K	-15.12%
Sep 30, 2025	PARK AVENUE SECURITIES LLC	0.08%	113.07K	345K	0	0
Sep 30, 2025	RHUMBLINE ADVISERS	0.09%	132.6K	404.43K	-4.93K	-3.59%
Sep 30, 2025	BARCLAYS PLC	0.1%	147.93K	451.19K	-29.7K	-16.72%
Sep 30, 2025	INVESCO LTD.	0.14%	201.95K	615.93K	51.53K	+34.26%
Sep 30, 2025	UBS GROUP AG	0.23%	346.14K	1.06M	21.02K	+6.46%
Sep 30, 2025	BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY	0.33%	482.55K	1.47M	0	0
Sep 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.33%	484.78K	1.48M	-23.33K	-4.59%
Sep 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.39%	574.12K	1.75M	242.09K	+72.91%
Sep 30, 2025	NUVEEN, LLC	0.46%	682.56K	2.08M	426.64K	+166.71%
Sep 30, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.55%	823K	2.51M	363K	+78.91%
Sep 30, 2025	J. GOLDMAN & CO LP	0.75%	1.11M	3.38M	1.11M	+100.00%
Sep 30, 2025	BANK OF AMERICA CORP /DE/	0.87%	1.29M	3.95M	-158.49K	-10.91%
Sep 30, 2025	BELLEVUE GROUP AG	3.48%	5.16M	15.73M	0	0
Sep 30, 2025	BANK OF NEW YORK MELLON CORP	0.21%	308.19K	939.98K	7.14K	+2.37%
Sep 30, 2025	FMR LLC	7.47%	11.08M	33.8M	-4.61M	-29.40%
Sep 30, 2025	WELLS FARGO & COMPANY/MN	0.28%	409.48K	1.25M	32.5K	+8.62%
Jun 30, 2025	MORGAN STANLEY	0.56%	832.54K	2B	131.18K	+18.70%
Jun 30, 2025	POINT72 ASIA (SINGAPORE) PTE. LTD.	0%	7.11K	17.07K	1.12K	+18.64%
Jun 30, 2025	HARBOR ADVISORS LLC	0.01%	10K	24K	0	0
Jun 30, 2025	CIBC WORLD MARKETS CORP	0.01%	11.8K	28.32K	-9.87K	-45.54%
Jun 30, 2025	49 WEALTH MANAGEMENT, LLC	0.01%	12.08K	29K	12.08K	+100.00%
Jun 30, 2025	COASTAL BRIDGE ADVISORS, LLC	0.01%	17K	40.8K	0	0
Jun 30, 2025	SIRIOS CAPITAL MANAGEMENT L P	0.67%	989.58K	2.37M	220.89K	+28.74%
Jun 30, 2025	SUSQUEHANNA PORTFOLIO STRATEGIES, LLC	0.14%	207.72K	498.52K	207.72K	+100.00%
Jun 30, 2025	AMERICAN CENTURY COMPANIES INC	0.14%	211.2K	506.87K	13K	+6.56%
Jun 30, 2025	ROYAL BANK OF CANADA	0.17%	245.2K	588K	238.37K	+3,487.93%
Jun 30, 2025		0.17%	255.92K	614.2K	-91.11K	-26.26%
Jun 30, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.17%	258.31K	48.62K	0	0
Jun 30, 2025	SCHONFELD STRATEGIC ADVISORS LLC	0.18%	266.05K	638.52K	154.85K	+139.25%
Jun 30, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.18%	266.81K	640.35K	67.59K	+33.93%
Jun 30, 2025	BANK OF NEW YORK MELLON CORP	0.2%	301.05K	722.52K	12.35K	+4.28%
Jun 30, 2025	UBS GROUP AG	0.22%	325.12K	780.29K	57.77K	+21.61%
Jun 30, 2025	WELLS FARGO & COMPANY/MN	0.25%	376.97K	904.74K	29.08K	+8.36%
Jun 30, 2025	J. SAFRA SARASIN HOLDING AG	0.26%	381.44K	915.46K	126.9K	+49.86%
Jun 30, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.27%	404.19K	970.07K	52.76K	+15.01%
Jun 30, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.29%	424.72K	1.02M	-312.55K	-42.39%
Jun 30, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.31%	460K	1.1M	0	0
Jun 30, 2025	BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY	0.33%	482.55K	1.16M	0	0
Jun 30, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.33%	484.63K	1.16M	7.07K	+1.48%
Jun 30, 2025	MILLENNIUM MANAGEMENT LLC	1.7%	2.51M	6.03M	2.34M	+1,334.16%
Jun 30, 2025	SIO CAPITAL MANAGEMENT, LLC	2.77%	4.1M	9.83M	697.98K	+20.54%
Jun 30, 2025	BELLEVUE GROUP AG	3.48%	5.16M	12.38M	0	0
Jun 30, 2025	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	3.54%	5.25M	12.6M	0	0
Jun 30, 2025	VANGUARD GROUP INC	3.62%	5.37M	12.88M	-13.62K	-0.25%
Jun 30, 2025	REDMILE GROUP, LLC	4.25%	6.3M	15.12M	0	0
Jun 30, 2025	BVF INC/IL	4.73%	7M	16.8M	0	0
Jun 30, 2025	BLACKROCK, INC.	5.38%	7.96M	19.11M	-564.14K	-6.62%
Jun 30, 2025	FMR LLC	10.6%	15.7M	37.67M	2.43M	+18.34%
Jun 30, 2025	CITIZENS FINANCIAL GROUP INC/RI	0.02%	35K	84K	35K	+100.00%
Jun 30, 2025	WALLEYE CAPITAL LLC	0.54%	794.64K	1.91M	-8.27K	-1.03%
Jun 30, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.49%	728.39K	1.75M	2.64K	+0.36%
Jun 30, 2025	LOS ANGELES CAPITAL MANAGEMENT LLC	0.01%	20.2K	48.47K	20.2K	+100.00%
Jun 30, 2025	QUADRATURE CAPITAL LTD	0.01%	20.52K	49.13K	2.78K	+15.69%
Jun 30, 2025	GOLDMAN SACHS GROUP INC	1.1%	1.63M	3.91B	789.07K	+93.76%
Jun 30, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.39%	583.91K	1.4M	0	0
Jun 30, 2025	DEUTSCHE BANK AG\	0.35%	511.45K	1.23M	-25.85K	-4.81%
Jun 30, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.34%	508.1K	1.22M	-16.64K	-3.17%
Jun 30, 2025	NORTHERN TRUST CORP	0.5%	743.22K	1.78M	-282.7K	-27.56%
Jun 30, 2025	RENAISSANCE TECHNOLOGIES LLC	0.53%	777.9K	1.87M	-384.54K	-33.08%
Jun 30, 2025	DIMENSIONAL FUND ADVISORS LP	0.6%	889.86K	2.14M	-97.02K	-9.83%
Jun 30, 2025	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.67%	987.51K	2.37M	-32.9K	-3.22%
Jun 30, 2025	BANK OF AMERICA CORP /DE/	0.98%	1.45M	3.49M	414.07K	+39.86%
Jun 30, 2025	STATE STREET CORP	1.34%	1.98M	4.75M	-58.84K	-2.88%
Jun 30, 2025	ACADIAN ASSET MANAGEMENT LLC	0.32%	469.21K	1.13M	265.22K	+130.02%
Jun 30, 2025	TWO SIGMA INVESTMENTS, LP	0.14%	201.16K	482.78K	201.16K	+100.00%
Jun 30, 2025	QUARRY LP	0.03%	43.13K	103.52K	22.13K	+105.40%
Jun 30, 2025	TD ASSET MANAGEMENT INC	0.03%	46.85K	112.44K	0	0
Jun 30, 2025	ALLEGHENY FINANCIAL GROUP LTD	0.03%	42.9K	102.96K	17.7K	+70.24%
Jun 30, 2025	MIRAE ASSET GLOBAL ETFS HOLDINGS LTD.	0.04%	52.41K	125.77K	-4.86K	-8.48%
Jun 30, 2025	INTECH INVESTMENT MANAGEMENT LLC	0.04%	52.7K	126.48K	-14.57K	-21.65%
Jun 30, 2025	BREVAN HOWARD CAPITAL MANAGEMENT LP	0.04%	53.28K	127.88K	-8.79K	-14.16%
Jun 30, 2025	ALPS ADVISORS INC	0.04%	59.2K	142.08K	-23.43K	-28.35%
Jun 30, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.04%	61.69K	148K	-121.6K	-66.34%
Jun 30, 2025	DNB ASSET MANAGEMENT AS	0.07%	99.57K	238.98K	25.2K	+33.87%
Jun 30, 2025	PARK AVENUE SECURITIES LLC	0.08%	113.07K	271K	30K	+36.12%
Jun 30, 2025	CINCTIVE CAPITAL MANAGEMENT LP	0.09%	135.47K	325.12K	0	0
Jun 30, 2025	IEQ CAPITAL, LLC	0.09%	135.8K	325.91K	55.8K	+69.75%
Jun 30, 2025	ALLIANCEBERNSTEIN L.P.	0.1%	140.74K	337.78M	29.44K	+26.45%
Jun 30, 2025	POINT72 EUROPE (LONDON) LLP	0.14%	206.8K	496.32K	163.08K	+372.98%
Jun 30, 2025	AQR CAPITAL MANAGEMENT LLC	0.22%	332.03K	796.88M	258.24K	+349.97%
Jun 30, 2025	VIRTUS INVESTMENT ADVISERS, INC.	0.02%	34.7K	83.28K	-1.7K	-4.67%
Jun 30, 2025	LIDO ADVISORS, LLC	0.02%	35K	84K	15K	+75.00%
Jun 30, 2025	MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	0.73%	1.08M	2.59M	48.28K	+4.68%
Jun 30, 2025	UBS OCONNOR LLC	0.33%	492.7K	1.18M	25.88K	+5.54%
Jun 30, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.58%	855.57K	2.05M	-19.15K	-2.19%
Jun 30, 2025	NUVEEN, LLC	0.17%	255.92K	614.2K	-91.11K	-26.26%
Jun 30, 2025	WOODLINE PARTNERS LP	0.71%	1.05M	2.53M	-1.06M	-50.17%
Jun 30, 2025	SPHERA FUNDS MANAGEMENT LTD.	1.19%	1.76M	4.23M	0	0
Jun 30, 2025	LOGOS GLOBAL MANAGEMENT LP	1.63%	2.41M	5.78M	-1.59M	-39.75%
Jun 30, 2025	CANDRIAM S.C.A.	1.71%	2.53M	6.08M	0	0
Jun 30, 2025	FOREFRONT ANALYTICS, LLC	0.02%	27.58K	66.18K	-1.02K	-3.55%
Jun 30, 2025	MARSHALL WACE, LLP	0.02%	29.99K	71.97K	29.99K	+100.00%
Jun 30, 2025	AMERIPRISE FINANCIAL INC	1.46%	2.17M	5.2M	-1.82M	-45.65%
Jun 30, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.54%	2.28M	5.48M	39.76K	+1.77%
Jun 30, 2025	VIRTU FINANCIAL LLC	0.02%	30.6K	73K	30.6K	+100.00%
Jun 30, 2025	NATIXIS	0.05%	77.1K	185.04K	77.1K	+100.00%
Jun 30, 2025	TFG ASSET MANAGEMENT GP LTD	1.9%	2.81M	6.74M	160K	+6.04%
Mar 31, 2025	QUBE RESEARCH & TECHNOLOGIES LTD	0.5%	737.27K	1.42M	275.9K	+59.80%
Mar 31, 2025	HENNION & WALSH ASSET MANAGEMENT, INC.	0.32%	477.57K	921.7K	47.98K	+11.17%
Mar 31, 2025	BVF INC/IL	4.73%	7M	13.51M	0	0
Mar 31, 2025	UBS GROUP AG	0.18%	267.35K	515.98K	-61.37K	-18.67%
Mar 31, 2025	MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	0.7%	1.03M	1.99M	1K	+0.10%
Mar 31, 2025	J. SAFRA SARASIN HOLDING AG	0.17%	254.54K	491.26K	98.79K	+63.43%
Mar 31, 2025	BLACKROCK, INC.	5.76%	8.53M	16.46M	40.32K	+0.48%
Mar 31, 2025	REDMILE GROUP, LLC	4.25%	6.3M	12.16M	0	0
Mar 31, 2025	SIO CAPITAL MANAGEMENT, LLC	2.29%	3.4M	6.56M	1.03M	+43.55%
Mar 31, 2025	TFG ASSET MANAGEMENT GP LTD	1.79%	2.65M	5.11M	1.25M	+89.29%
Mar 31, 2025	CANDRIAM S.C.A.	1.71%	2.53M	4.89M	0	0
Mar 31, 2025	GEODE CAPITAL MANAGEMENT, LLC	1.52%	2.25M	4.33M	73.53K	+3.39%
Mar 31, 2025	WOODLINE PARTNERS LP	1.43%	2.11M	4.08M	-576.09K	-21.41%
Mar 31, 2025	SPHERA FUNDS MANAGEMENT LTD.	1.19%	1.76M	3.41M	521.35K	+41.94%
Mar 31, 2025	WELLS FARGO & COMPANY/MN	0.23%	347.89K	671.43K	112.14K	+47.57%
Mar 31, 2025	BANK OF NEW YORK MELLON CORP	0.19%	288.7K	557.19K	58.15K	+25.22%
Mar 31, 2025	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.12%	183.29K	354K	99.85K	+119.67%
Mar 31, 2025	MILLENNIUM MANAGEMENT LLC	0.12%	175.3K	338.34K	19.63K	+12.61%
Mar 31, 2025	JPMORGAN CHASE & CO	0.97%	1.43M	2.76M	-79.55K	-5.26%
Mar 31, 2025	RENAISSANCE TECHNOLOGIES LLC	0.78%	1.16M	2.24M	668.74K	+135.45%
Mar 31, 2025	BANK OF AMERICA CORP /DE/	0.7%	1.04M	2M	1.01M	+3,369.35%
Mar 31, 2025	NORTHERN TRUST CORP	0.69%	1.03M	1.98M	-3.83K	-0.37%
Mar 31, 2025	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.69%	1.02M	1.97M	3.85K	+0.38%
Mar 31, 2025	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.39%	583.91K	1.13M	0	0
Mar 31, 2025	UBS OCONNOR LLC	0.32%	466.82K	900.96K	147.94K	+46.39%
Mar 31, 2025	RHENMAN & PARTNERS ASSET MANAGEMENT AB	0.31%	460K	887.8K	-82.5K	-15.21%
Mar 31, 2025	WELLINGTON MANAGEMENT GROUP LLP	0.24%	356.48K	688.01K	88.31K	+32.93%
Mar 31, 2025	PARKMAN HEALTHCARE PARTNERS LLC	0.24%	351.44K	678.27K	20.59K	+6.22%
Mar 31, 2025	FMR LLC	8.95%	13.26M	25.6M	-962.06K	-6.76%
Mar 31, 2025	WALLEYE CAPITAL LLC	0.54%	802.91K	1.55M	146.58K	+22.33%
Mar 31, 2025	VANGUARD GROUP INC	3.63%	5.38M	10.38M	-167.26K	-3.02%
Mar 31, 2025	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	3.54%	5.25M	10.13M	0	0
Mar 31, 2025	BELLEVUE GROUP AG	3.48%	5.16M	9.95M	0	0
Mar 31, 2025	LOGOS GLOBAL MANAGEMENT LP	2.7%	4M	7.72M	1.45M	+56.86%
Mar 31, 2025	AMERIPRISE FINANCIAL INC	2.69%	3.99M	7.69M	3.06M	+330.08%
Mar 31, 2025	DEUTSCHE BANK AG\	0.36%	537.29K	1.04M	791	+0.15%
Mar 31, 2025	PRICE T ROWE ASSOCIATES INC /MD/	0.35%	524.74K	1.01M	-579.64K	-52.49%
Mar 31, 2025	DRIEHAUS CAPITAL MANAGEMENT LLC	0.17%	258.31K	104.32K	0	0
Mar 31, 2025	ACADIAN ASSET MANAGEMENT LLC	0.14%	203.99K	393K	48.35K	+31.06%
Mar 31, 2025	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.13%	199.23K	384.5K	136.38K	+217.03%
Mar 31, 2025	AMERICAN CENTURY COMPANIES INC	0.13%	198.19K	382.52K	19.68K	+11.03%
Mar 31, 2025	BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY	0.33%	482.55K	931.32K	0	0
Mar 31, 2025	STATE STREET CORP	1.38%	2.04M	3.94M	-2.47M	-54.78%
Mar 31, 2025	DIMENSIONAL FUND ADVISORS LP	0.67%	986.88K	1.91M	-373.2K	-27.44%
Mar 31, 2025		0.23%	347.03K	669.77K	347.03K	+100.00%
Mar 31, 2025	KENNEDY CAPITAL MANAGEMENT LLC	0.59%	874.73K	1.69M	-217.11K	-19.88%
Mar 31, 2025	GOLDMAN SACHS GROUP INC	0.57%	841.58K	1.62M	-475.43K	-36.10%
Mar 31, 2025	SIRIOS CAPITAL MANAGEMENT L P	0.52%	768.69K	1.48M	768.69K	+100.00%
Mar 31, 2025	MORGAN STANLEY	0.47%	701.36K	1.35M	56.68K	+8.79%
Mar 31, 2025	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.49%	725.75K	1.4M	-18.04K	-2.43%
Mar 31, 2024	JUMP FINANCIAL, LLC	0.27%	210.2K	1.51M	210.2K	+100.00%
Mar 31, 2024	CITADEL ADVISORS LLC	0.33%	258.68K	1.85M	-799.01K	-75.54%
Mar 31, 2024	SOLEUS CAPITAL MANAGEMENT, L.P.	0.37%	292.4K	2.1M	-223K	-43.27%
Mar 31, 2024	NUVEEN ASSET MANAGEMENT, LLC	0.39%	308.06K	2.21M	113.46K	+58.30%
Mar 31, 2024	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.4%	315.16K	2.26M	-27.78K	-8.10%
Mar 31, 2024	MARSHALL WACE, LLP	0.4%	315.61K	2.26M	315.61K	+100.00%
Mar 31, 2024	DIMENSIONAL FUND ADVISORS LP	0.43%	333.91K	2.39M	246.87K	+283.60%
Mar 31, 2024	PARKMAN HEALTHCARE PARTNERS LLC	0.44%	346.69K	2.49M	346.69K	+100.00%
Mar 31, 2024	TWO SIGMA INVESTMENTS, LP	0.48%	373.45K	2.68M	346.87K	+1,304.84%
Mar 31, 2024	BOOTHBAY FUND MANAGEMENT, LLC	0.48%	375.28K	2.69M	-332.54K	-46.98%
Mar 31, 2024	D. E. SHAW & CO., INC.	0.48%	379.25K	2.72M	379.25K	+100.00%
Mar 31, 2024	UBS OCONNOR LLC	0.32%	248.28K	1.78M	-444.65K	-64.17%
Mar 31, 2024	BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY	0.62%	482.55K	3.46M	0	0
Mar 31, 2024	CAPTION MANAGEMENT, LLC	0.51%	402.5K	2.89M	402.5K	+100.00%
Mar 31, 2024	NORTHERN TRUST CORP	0.71%	555.57K	3.98M	188.29K	+51.27%
Mar 31, 2024	GOLDMAN SACHS GROUP INC	0.72%	562.97K	4.04M	278.03K	+97.58%
Mar 31, 2024	SCHONFELD STRATEGIC ADVISORS LLC	0.97%	761.6K	5.46M	744.6K	+4,380.00%
Mar 31, 2024	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	0.99%	773.91K	5.55M	-4.05K	-0.52%
Mar 31, 2024	KENNEDY CAPITAL MANAGEMENT LLC	0.99%	774.7K	5.55M	-301.03K	-27.98%
Mar 31, 2024	INVESCO LTD.	1.01%	789.04K	5.66M	767.27K	+3,524.12%
Mar 31, 2024	JPMORGAN CHASE & CO	1.23%	959.65K	6.88M	930.06K	+3,143.70%
Mar 31, 2024	POLAR CAPITAL HOLDINGS PLC	1.28%	1M	7.17M	1M	+100.00%
Mar 31, 2024	STATE STREET CORP	1.53%	1.2M	8.59M	351.85K	+41.58%
Mar 31, 2024	MILLENNIUM MANAGEMENT LLC	1.63%	1.28M	9.16M	467.17K	+57.60%
Mar 31, 2024	PRICE T ROWE ASSOCIATES INC /MD/	1.69%	1.32M	9.49M	1.31M	+10,482.01%
Mar 31, 2024	IKARIAN CAPITAL, LLC	1.8%	1.41M	10.07M	-1.25M	-46.98%
Mar 31, 2024	FMR LLC	11.98%	9.37M	67.2M	-312.58K	-3.23%
Mar 31, 2024	MORGAN STANLEY	1.15%	899.51K	6.45M	707.45K	+368.35%
Mar 31, 2024	ACADIAN ASSET MANAGEMENT LLC	1.22%	957.99K	6.87M	83.97K	+9.61%
Mar 31, 2024	GEODE CAPITAL MANAGEMENT, LLC	1.83%	1.43M	10.25M	507.25K	+55.00%
Mar 31, 2024	PICTET ASSET MANAGEMENT HOLDING SA	2.1%	1.64M	11.79M	-158.56K	-8.79%
Mar 31, 2024	WOODLINE PARTNERS LP	2.56%	2M	14.34M	609	+0.03%
Mar 31, 2024	OCTAGON CAPITAL ADVISORS LP	2.62%	2.05M	14.7M	0	0
Mar 31, 2024	BELLEVUE GROUP AG	2.79%	2.18M	15.65M	2.18M	+100.00%
Mar 31, 2024	GMT CAPITAL CORP	3.38%	2.65M	18.97M	-374.95K	-12.41%
Mar 31, 2024	LOGOS GLOBAL MANAGEMENT LP	1.28%	1M	7.17M	1M	+100.00%
Mar 31, 2024	VANGUARD GROUP INC	4.79%	3.75M	26.87M	1.84M	+96.38%
Mar 31, 2024	ADAGE CAPITAL PARTNERS GP, L.L.C.	5.52%	4.32M	30.97M	-680K	-13.60%
Mar 31, 2024	BLACKROCK INC.	6.45%	5.04M	36.16M	1.72M	+51.98%
Mar 31, 2024	POINT72 ASSET MANAGEMENT, L.P.	6.59%	5.16M	36.97M	5.16M	+100.00%
Mar 31, 2024	REDMILE GROUP, LLC	7.04%	5.5M	39.46M	0	0
Mar 31, 2024	ALERCE INVESTMENT MANAGEMENT, L.P.	9.47%	7.41M	53.1M	0	0
Mar 31, 2024	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.75%	583.91K	4.19M	0	0
Mar 31, 2024	STEMPOINT CAPITAL LP	0.77%	605.12K	4.34M	-1.98K	-0.33%
Mar 31, 2024	RENAISSANCE TECHNOLOGIES LLC	0.86%	671.2K	4.81M	187K	+38.62%
Mar 31, 2024	BVF INC/IL	8.95%	7M	50.19M	0	0
Mar 31, 2024	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	11.13%	8.7M	62.4M	641.55K	+7.96%
Mar 31, 2024	CITIGROUP INC	0.02%	12.88K	92.34K	5.83K	+82.58%
Mar 31, 2024	49 WEALTH MANAGEMENT, LLC	0.02%	13.29K	88.13K	-2.8K	-17.40%
Mar 31, 2024	ENTRYPOINT CAPITAL, LLC	0.02%	13.62K	97.64K	13.62K	+100.00%
Mar 31, 2024	QUBE RESEARCH & TECHNOLOGIES LTD	0.02%	14.81K	106.16K	14.81K	+100.00%
Mar 31, 2024	BELVEDERE TRADING LLC	0.02%	16.45K	117.92K	16.45K	+100.00%
Mar 31, 2024	ALLEGHENY FINANCIAL GROUP LTD	0.03%	21.7K	155.59K	0	0
Mar 31, 2024	SG AMERICAS SECURITIES, LLC	0.03%	21.7K	156K	-3.63K	-14.33%
Mar 31, 2024	AXQ CAPITAL, LP	0.03%	25.7K	184.27K	25.7K	+100.00%
Mar 31, 2024	GSA CAPITAL PARTNERS LLP	0.03%	25.71K	184K	25.71K	+100.00%
Mar 31, 2024	WELLS FARGO & COMPANY/MN	0.04%	28.91K	207.25K	12.47K	+75.91%
Mar 31, 2024	AMERICAN INTERNATIONAL GROUP, INC.	0.04%	33.2K	238.02K	10.51K	+46.33%
Mar 31, 2024	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	0.04%	33.57K	240.7K	33.57K	+100.00%
Mar 31, 2024	LINCOLN NATIONAL CORP	0.04%	35K	250.95K	35K	+100.00%
Mar 31, 2024	METLIFE INVESTMENT MANAGEMENT, LLC	0.04%	35.01K	251K	35.01K	+100.00%
Mar 31, 2024	DNB ASSET MANAGEMENT AS	0.05%	35.91K	257.48K	35.91K	+100.00%
Mar 31, 2024	PRUDENTIAL FINANCIAL INC	0.05%	37.13K	266.19K	-43.48K	-53.94%
Mar 31, 2024	ALLIANCEBERNSTEIN L.P.	0.05%	40.62K	291.25K	0	0
Mar 31, 2024	CORNERCAP INVESTMENT COUNSEL INC	0.06%	46.7K	334.83K	0	0
Mar 31, 2024	SIMPLEX TRADING, LLC	0.08%	63.3K	453K	56.54K	+837.29%
Mar 31, 2024	AMERICAN CENTURY COMPANIES INC	0.1%	78.42K	562.27K	44.56K	+131.57%
Mar 31, 2024	RHUMBLINE ADVISERS	0.1%	81.98K	587.77K	22.66K	+38.20%
Mar 31, 2024	UBS GROUP AG	0.12%	91.05K	652.8K	41.46K	+83.61%
Mar 31, 2024	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.12%	93.81K	672.59K	73.79K	+368.54%
Mar 31, 2024	LIGHTHOUSE INVESTMENT PARTNERS, LLC	0.16%	122.78K	880.36K	55.27K	+81.87%
Mar 31, 2024	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.18%	141.04K	1.01M	52.95K	+60.10%
Mar 31, 2024	SUSQUEHANNA PORTFOLIO STRATEGIES, LLC	0.18%	141.56K	1.02M	141.56K	+100.00%
Mar 31, 2024	SUSQUEHANNA INTERNATIONAL GROUP, LLP	0.09%	73.5K	527K	73.5K	+100.00%
Mar 31, 2024	TD ASSET MANAGEMENT INC	0.23%	176.2K	1.26B	176.2K	+100.00%
Mar 31, 2024	BANK OF NEW YORK MELLON CORP	0.23%	180.62K	1.3M	46.34K	+34.51%
Mar 31, 2024	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.23%	181.05K	1.3M	57.38K	+46.40%
Dec 31, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.22%	922.23K	4.19M	42.62K	+4.84%
Dec 31, 2023	BANK OF AMERICA CORP /DE/	0.07%	51.32K	233.01K	5.44K	+11.86%
Dec 31, 2023	RHUMBLINE ADVISERS	0.08%	59.32K	269.3K	-390	-0.65%
Dec 31, 2023	LIGHTHOUSE INVESTMENT PARTNERS, LLC	0.09%	67.51K	306.5K	67.51K	+100.00%
Dec 31, 2023	PRUDENTIAL FINANCIAL INC	0.11%	80.61K	365.95K	-92.2K	-53.35%
Dec 31, 2023	TWO SIGMA ADVISERS, LP	0.11%	84.8K	384.99K	-70.4K	-45.36%
Dec 31, 2023	DIMENSIONAL FUND ADVISORS LP	0.12%	87.05K	395.26K	28.53K	+48.74%
Dec 31, 2023	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.12%	88.09K	399.93K	-33.3K	-27.43%
Dec 31, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.16%	123.67K	561.45K	0	0
Dec 31, 2023	BANK OF NEW YORK MELLON CORP	0.18%	134.28K	609.62K	-20K	-12.96%
Dec 31, 2023	DEUTSCHE BANK AG\	0.21%	157K	712.79K	157K	+100.00%
Dec 31, 2023	BRIDGEWAY CAPITAL MANAGEMENT, LLC	0.24%	179.5K	814.93K	14.4K	+8.72%
Dec 31, 2023	BARCLAYS PLC	0.25%	185.33K	841K	149.6K	+418.68%
Dec 31, 2023	MORGAN STANLEY	0.25%	192.06K	871.95K	42.97K	+28.82%
Dec 31, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.26%	194.6K	883.47K	6.46K	+3.43%
Dec 31, 2023	DRIEHAUS CAPITAL MANAGEMENT LLC	0.34%	258.31K	208.15K	0	0
Dec 31, 2023	GOLDMAN SACHS GROUP INC	0.38%	284.93K	1.29M	39.28K	+15.99%
Dec 31, 2023	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.46%	342.94K	1.56M	33.23K	+10.73%
Dec 31, 2023	NORTHERN TRUST CORP	0.49%	367.28K	1.67M	6.04K	+1.67%
Dec 31, 2023	WALLEYE CAPITAL LLC	0.5%	378.28K	1.72M	378.28K	+100.00%
Dec 31, 2023	SILVERARC CAPITAL MANAGEMENT, LLC	0.55%	417.43K	1.9M	17.71K	+4.43%
Dec 31, 2023	BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY	0.64%	482.55K	2.19M	-11.62K	-2.35%
Dec 31, 2023	RENAISSANCE TECHNOLOGIES LLC	0.64%	484.2K	2.2M	-77.11K	-13.74%
Dec 31, 2023	SOLEUS CAPITAL MANAGEMENT, L.P.	0.68%	515.4K	2.34M	0	0
Dec 31, 2023	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.78%	583.91K	2.65M	0	0
Dec 31, 2023	VONTOBEL HOLDING LTD.	0.86%	650.91K	2.96M	-247.87K	-27.58%
Dec 31, 2023	SECTORAL ASSET MANAGEMENT INC	0.86%	650.91K	2.96M	-247.87K	-27.58%
Dec 31, 2023	UBS OCONNOR LLC	0.92%	692.93K	3.15M	143.68K	+26.16%
Dec 31, 2023	BOOTHBAY FUND MANAGEMENT, LLC	0.94%	707.82K	3.21M	707.82K	+100.00%
Dec 31, 2023	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	1.03%	777.97K	3.53M	769	+0.10%
Dec 31, 2023	MILLENNIUM MANAGEMENT LLC	1.08%	811.02K	3.68M	588.74K	+264.87%
Dec 31, 2023	STATE STREET CORP	1.12%	846.27K	3.84M	14.73K	+1.77%
Dec 31, 2023	ACADIAN ASSET MANAGEMENT LLC	1.16%	874.02K	3.97M	61.8K	+7.61%
Dec 31, 2023	CITADEL ADVISORS LLC	1.4%	1.06M	4.8M	372.73K	+54.42%
Dec 31, 2023	KENNEDY CAPITAL MANAGEMENT LLC	1.43%	1.08M	4.88M	98.74K	+10.11%
Dec 31, 2023		0.81%	607.1K	2.76M	607.1K	+100.00%
Dec 31, 2023	VANGUARD GROUP INC	2.53%	1.91M	8.66M	13.92K	+0.73%
Dec 31, 2023	WOODLINE PARTNERS LP	2.65%	2M	9.08M	535.64K	+36.58%
Dec 31, 2023	OCTAGON CAPITAL ADVISORS LP	2.72%	2.05M	9.31M	0	0
Dec 31, 2023	IKARIAN CAPITAL, LLC	3.52%	2.65M	12.03M	2.65M	+100.00%
Dec 31, 2023	GMT CAPITAL CORP	4.01%	3.02M	13.71M	210K	+7.47%
Dec 31, 2023	BLACKROCK INC.	4.4%	3.32M	15.07M	-89.41K	-2.62%
Dec 31, 2023	LOGOS GLOBAL MANAGEMENT LP	6.57%	4.95M	22.47M	-350K	-6.60%
Dec 31, 2023	ADAGE CAPITAL PARTNERS GP, L.L.C.	6.64%	5M	22.7M	2.65M	+112.77%
Dec 31, 2023	REDMILE GROUP, LLC	7.3%	5.5M	24.98M	2M	+57.09%
Dec 31, 2023	BVF INC/IL	9.29%	7M	31.78M	7M	+100.00%
Dec 31, 2023	ALERCE INVESTMENT MANAGEMENT, L.P.	9.83%	7.41M	33.62M	350K	+4.96%
Dec 31, 2023	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	10.7%	8.06M	36.6M	2.36M	+41.39%
Dec 31, 2023	FMR LLC	12.86%	9.69M	43.97M	9.59M	+10,452.61%
Sep 30, 2023	BLACKROCK INC.	4.53%	3.41M	-	-71.91K	-2.07%
Sep 30, 2023	HSBC HOLDINGS PLC	0.03%	19.26K	-	19.26K	+100.00%
Sep 30, 2023	MANUFACTURERS LIFE INSURANCE COMPANY, THE	0.03%	20.02K	-	0	0
Sep 30, 2023	KESTRA ADVISORY SERVICES, LLC	0.03%	21K	-	-4K	-16.00%
Sep 30, 2023	VOYA INVESTMENT MANAGEMENT LLC	0.03%	21.48K	-	2.71K	+14.43%
Sep 30, 2023	ALLEGHENY FINANCIAL GROUP LTD	0.03%	21.7K	-	21.7K	+100.00%
Sep 30, 2023	SG AMERICAS SECURITIES, LLC	0.03%	22.21K	-	22.21K	+100.00%
Sep 30, 2023	AMERICAN INTERNATIONAL GROUP, INC.	0.03%	22.78K	-	810	+3.69%
Sep 30, 2023	AMERICAN CENTURY COMPANIES INC	0.03%	24.17K	-	5.04K	+26.35%
Sep 30, 2023	UBS GROUP AG	0.03%	24.65K	-	-2.28K	-8.47%
Sep 30, 2023	FOREFRONT ANALYTICS, LLC	0.04%	31.68K	-	4.89K	+18.25%
Sep 30, 2023	BARCLAYS PLC	0.05%	35.73K	-	-2.99K	-7.73%
Sep 30, 2023	TWO SIGMA INVESTMENTS, LP	0.05%	37.1K	-	-201.2K	-84.43%
Sep 30, 2023	ALLIANCEBERNSTEIN L.P.	0.05%	40.62K	-	0	0
Sep 30, 2023	PARALLAX VOLATILITY ADVISERS, L.P.	0.06%	41.54K	-	41.54K	+100.00%
Sep 30, 2023	ALGERT GLOBAL LLC	0.06%	41.66K	-	3K	+7.76%
Sep 30, 2023	CORNERCAP INVESTMENT COUNSEL INC	0.06%	46.7K	-	-563	-1.19%
Sep 30, 2023	DIMENSIONAL FUND ADVISORS LP	0.08%	58.52K	-	16	+0.03%
Sep 30, 2023	RHUMBLINE ADVISERS	0.08%	59.71K	-	4.68K	+8.50%
Sep 30, 2023	FMR LLC	0.12%	91.78K	-	-1.31M	-93.47%
Sep 30, 2023	CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD.	0.16%	121.39K	-	-20.33K	-14.35%
Sep 30, 2023	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	0.16%	123.67K	-	0	0
Sep 30, 2023	SCHONFELD STRATEGIC ADVISORS LLC	0.2%	147.35K	-	124.85K	+554.87%
Sep 30, 2023	MORGAN STANLEY	0.2%	149.09K	-	41.76K	+38.90%
Sep 30, 2023	BANK OF NEW YORK MELLON CORP	0.21%	154.28K	-	0	0
Sep 30, 2023	TWO SIGMA ADVISERS, LP	0.21%	155.2K	-	-94.9K	-37.94%
Sep 30, 2023	PRUDENTIAL FINANCIAL INC	0.23%	172.81K	-	172.81K	+100.00%
Sep 30, 2023	NUVEEN ASSET MANAGEMENT, LLC	0.25%	188.14K	-	0	0
Sep 30, 2023	GOLDMAN SACHS GROUP INC	0.33%	245.66K	-	158.25K	+181.05%
Sep 30, 2023	DRIEHAUS CAPITAL MANAGEMENT LLC	0.34%	258.31K	-	-494.2K	-65.67%
Sep 30, 2023	EXODUSPOINT CAPITAL MANAGEMENT, LP	0.41%	309.71K	-	-29.39K	-8.67%
Sep 30, 2023	NORTHERN TRUST CORP	0.48%	361.24K	-	-17.96K	-4.74%
Sep 30, 2023	SILVERARC CAPITAL MANAGEMENT, LLC	0.53%	399.72K	-	9.81K	+2.51%
Sep 30, 2023	VELAN CAPITAL INVESTMENT MANAGEMENT LP	0.61%	459.75K	-	0	0
Sep 30, 2023	ALERCE INVESTMENT MANAGEMENT, L.P.	9.38%	7.06M	-	0	0
Sep 30, 2023	FEDERATED HERMES, INC.	0.64%	485.05K	-	-2.57M	-84.14%
Sep 30, 2023	SIMPLIFY ASSET MANAGEMENT INC.	0.65%	492.6K	-	-160.89K	-24.62%
Sep 30, 2023	BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY	0.66%	494.17K	-	11.62K	+2.41%
Sep 30, 2023	SOLEUS CAPITAL MANAGEMENT, L.P.	0.69%	515.4K	-	-105K	-16.92%
Sep 30, 2023	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	0.78%	583.91K	-	0	0
Sep 30, 2023	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	1.03%	777.2K	-	1.35K	+0.17%
Sep 30, 2023	ACADIAN ASSET MANAGEMENT LLC	1.08%	812.22K	-	-8.34K	-1.02%
Sep 30, 2023	GEODE CAPITAL MANAGEMENT, LLC	1.17%	879.62K	-	-3.89K	-0.44%
Sep 30, 2023	VONTOBEL HOLDING LTD.	1.19%	898.79K	-	224.16K	+33.23%
Sep 30, 2023	SECTORAL ASSET MANAGEMENT INC	1.19%	898.79K	-	224.16K	+33.23%
Sep 30, 2023	BLACKSTONE INC.	1.21%	910.49K	-	0	0
Sep 30, 2023	KENNEDY CAPITAL MANAGEMENT LLC	1.3%	976.99K	-	976.99K	+100.00%
Sep 30, 2023	WOODLINE PARTNERS LP	1.95%	1.46M	-	759.74K	+107.82%
Sep 30, 2023		2.4%	1.8M	-	1.8M	+100.00%
Sep 30, 2023	GMT CAPITAL CORP	3.74%	2.81M	-	345.9K	+14.03%

Insiders

Insiders	Designation	Shares Held
SATTER MUNEER A	director	9.73M
BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	10 percent owner	5.7M
CLARUS LIFESCIENCES III, L.P.	10 percent owner	2.73M
FLYNN JAMES E	10 percent owner	808.91K
LOVE DOUGLAS	PRESIDENT AND CEO	351.55K
OVERDORF MICHAEL	EVP & CHIEF BUSINESS OFFICER	130.69K
LEW JENNIFER	EVP & CHIEF FINANCIAL OFFICER	121.62K
YEDNOCK TED	EVP & CHIEF INNOVATION OFFICER	105.08K
ARTIS DEAN RICHARD	EVP & CHIEF SCIENTIFIC OFFICER	83.81K
CARSON WILLIAM H.	director	54.41K
DANANBERG JAMIE	CHIEF MEDICAL OFFICER	33.48K
CHOI JUNG	director	33K
KESWANI SANJAY	EVP & Chief Medical Officer	0

Buying/Selling by Insiders

Date	Insider	Type	Cost	Shares	Value ($)	Shares Total
Dec 30, 2025	CARSON WILLIAM H.	PURCHASE	5.02	4.12K	20.66K	54.41K
Dec 01, 2025	CARSON WILLIAM H.	PURCHASE	4.47	4.12K	18.39K	50.29K
Dec 01, 2025	CHOI JUNG	PURCHASE	4.19	33K	138.27K	33K
Nov 21, 2025	SATTER MUNEER A	PURCHASE	4.28	422.61K	1.81M	9.73M
Nov 20, 2025	SATTER MUNEER A	PURCHASE	4.48	400K	1.79M	9.31M
Nov 19, 2025	SATTER MUNEER A	PURCHASE	3.94	500K	1.97M	8.91M
Nov 18, 2025	SATTER MUNEER A	PURCHASE	3.18	500K	1.59M	8.41M
Nov 17, 2025	SATTER MUNEER A	PURCHASE	2.99	500K	1.5M	7.91M
Oct 30, 2025	CARSON WILLIAM H.	PURCHASE	3.17	4.12K	13.04K	46.18K
Sep 30, 2025	CARSON WILLIAM H.	PURCHASE	3.05	4.12K	12.55K	42.06K
Sep 02, 2025	CARSON WILLIAM H.	PURCHASE	2.09	4.12K	8.6K	37.95K
Jul 30, 2025	CARSON WILLIAM H.	PURCHASE	2.43	4.12K	10K	33.83K
Jul 14, 2025	OVERDORF MICHAEL	SALE	2.61	853	2.23K	130.69K
Jul 14, 2025	YEDNOCK TED	SALE	2.58	1.12K	2.88K	105.08K
Jul 14, 2025	LEW JENNIFER	SALE	2.58	1.12K	2.88K	121.62K
Jun 30, 2025	CARSON WILLIAM H.	PURCHASE	2.46	4.12K	10.12K	29.72K
Feb 18, 2025	LEW JENNIFER	SALE	2.92	6.91K	20.18K	77.77K
Feb 18, 2025	YEDNOCK TED	SALE	2.91	8.35K	24.28K	61.24K
Feb 18, 2025	ARTIS DEAN RICHARD	SALE	2.97	5.52K	16.38K	83.81K
Feb 18, 2025	DANANBERG JAMIE	SALE	2.96	5.52K	16.34K	33.48K
Feb 18, 2025	OVERDORF MICHAEL	SALE	2.95	6.62K	19.52K	86.58K
Feb 13, 2025	YEDNOCK TED	SALE	2.99	1.78K	5.33K	69.58K
Feb 13, 2025	LOVE DOUGLAS	SALE	2.95	5.02K	14.81K	351.55K
Feb 13, 2025	OVERDORF MICHAEL	SALE	2.99	1.43K	4.26K	93.2K
Feb 13, 2025	LEW JENNIFER	SALE	2.98	1.79K	5.32K	84.68K
Dec 02, 2024	CARSON WILLIAM H.	PURCHASE	5.33	3.2K	17.06K	25.6K
Oct 15, 2024	YEDNOCK TED	SALE	7.41	5.41K	40.07K	71.37K
Oct 01, 2024	CARSON WILLIAM H.	PURCHASE	5.97	3.2K	19.1K	22.4K
Sep 19, 2024	YEDNOCK TED	SALE	7.10	4.5K	31.95K	0
Sep 12, 2024	YEDNOCK TED	SALE	6.16	5.5K	33.88K	4.5K
Sep 05, 2024	YEDNOCK TED	SALE	5.64	5.5K	31.02K	10K
Sep 03, 2024	CARSON WILLIAM H.	PURCHASE	5.48	3.2K	17.54K	19.2K
Aug 29, 2024	YEDNOCK TED	SALE	5.95	5.5K	32.73K	15.5K
Aug 01, 2024	CARSON WILLIAM H.	PURCHASE	6.24	3.2K	19.97K	16K
Jul 15, 2024	LEW JENNIFER	SALE	6.03	1.1K	6.66K	86.47K
Jul 15, 2024	YEDNOCK TED	SALE	6.02	1.11K	6.66K	71.37K
Jul 15, 2024	OVERDORF MICHAEL	SALE	6.02	784	4.72K	94.62K
Jul 01, 2024	CARSON WILLIAM H.	PURCHASE	5.00	3.2K	16K	12.8K
Jun 03, 2024	CARSON WILLIAM H.	PURCHASE	4.83	3.2K	15.46K	9.6K
May 01, 2024	CARSON WILLIAM H.	PURCHASE	4.68	3.2K	14.98K	6.4K
Apr 08, 2024	CARSON WILLIAM H.	PURCHASE	6.07	3.2K	19.41K	3.2K
Feb 20, 2024	OVERDORF MICHAEL	SALE	5.48	1.95K	10.69K	85.64K
Feb 20, 2024	LEW JENNIFER	SALE	5.53	2.59K	14.34K	82.06K
Feb 20, 2024	YEDNOCK TED	SALE	5.51	2.6K	14.35K	72.47K
Feb 12, 2024	YEDNOCK TED	SALE	5.54	1.81K	10.03K	36.08K
Feb 12, 2024	LOVE DOUGLAS	SALE	5.54	5.78K	32.03K	196.12K
Feb 12, 2024	OVERDORF MICHAEL	SALE	5.53	1.35K	7.46K	48.59K
Feb 12, 2024	LEW JENNIFER	SALE	5.54	1.81K	10.02K	45.65K
Dec 27, 2023	YEDNOCK TED	SALE	4.52	21K	94.97K	0
Dec 26, 2023	SATTER MUNEER A	PURCHASE	2.88	350K	1.01M	7.41M
Jul 11, 2023	YEDNOCK TED	SALE	3.84	1.06K	4.05K	37.89K
Jul 11, 2023	LEW JENNIFER	SALE	3.84	1.06K	4.05K	47.46K
Jul 11, 2023	OVERDORF MICHAEL	SALE	3.84	978	3.75K	45.8K
May 25, 2023	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	PURCHASE	2.13	300K	639.72K	5.7M
Feb 15, 2023	LOVE DOUGLAS	SALE	5.87	6.57K	38.56K	197.65K
Feb 14, 2023	LEW JENNIFER	SALE	6.30	166	1.05K	29.54K
Feb 14, 2023	OVERDORF MICHAEL	SALE	6.30	144	907.1	27.81K
Feb 13, 2023	OVERDORF MICHAEL	SALE	6.30	1.5K	9.46K	27.95K
Feb 13, 2023	LEW JENNIFER	SALE	6.31	1.74K	10.99K	29.71K
Feb 10, 2023	SATTER MUNEER A	PURCHASE	6.80	2.65M	18M	7.06M
Jul 07, 2022	SATTER MUNEER A	PURCHASE	0.13	613.5K	76.69K	613.5K
Apr 14, 2022	LOVE DOUGLAS	PURCHASE	2.45	60K	146.81K	200.94K
Sep 16, 2021	LOVE DOUGLAS	SALE	22.05	7.5K	165.34K	0
Sep 13, 2021	YEDNOCK TED	SALE	20.00	16.19K	323.86K	0
Sep 13, 2021	LEW JENNIFER	SALE	20.01	3.5K	70.03K	2K
Jun 08, 2021	LOVE DOUGLAS	SALE	22.55	3.75K	84.56K	0
Jun 07, 2021	LOVE DOUGLAS	SALE	22.31	3.75K	83.67K	0
Jun 03, 2021	YEDNOCK TED	SALE	21.72	2.18K	47.44K	0
May 27, 2021	LEW JENNIFER	SALE	22.24	3.5K	77.84K	2K
Apr 01, 2021	LOVE DOUGLAS	SALE	28.01	300	8.4K	0
Mar 31, 2021	LOVE DOUGLAS	SALE	28.11	7.1K	199.62K	0
Mar 30, 2021	LOVE DOUGLAS	SALE	24.78	1.85K	45.85K	0
Mar 29, 2021	LOVE DOUGLAS	SALE	27.24	300	8.17K	0
Mar 25, 2021	YEDNOCK TED	SALE	29.96	237	7.1K	0
Mar 24, 2021	KESWANI SANJAY	SALE	30.17	4K	120.51K	0
Mar 23, 2021	LEW JENNIFER	SALE	29.16	1.8K	52.49K	2K
Jul 28, 2020	SATTER MUNEER A	PURCHASE	17.00	200K	3.4M	1.95M
Jul 28, 2020	BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC	PURCHASE	17.00	400K	6.8M	3.24M
Jul 28, 2020	CLARUS LIFESCIENCES III, L.P.	PURCHASE	17.00	200K	3.4M	2.73M
Jul 28, 2020	LEW JENNIFER	PURCHASE	17.00	2K	34K	2K
Jul 28, 2020	FLYNN JAMES E	PURCHASE	17.00	350K	5.95M	808.91K

Insider Transaction Summary (6 Months)

SHARESTRANS

PURCHASE2.38M11

SALES00

NET SHARES2.38M11

SHARES HELD44.52M11

% NET SHARES-94.66%0%

ANNX Stock Ownership Breakdown

Annexon

Stock Outstanding Shares

Market Insider

Institutional Ownership

Insiders

Buying/Selling by Insiders

Insider Transaction Summary (6 Months)

Frequently Asked Questions

Stock Outstanding Shares

Market Insider

Institutional Ownership

Insiders

Buying/Selling by Insiders

Insider Transaction Summary (6 Months)

Frequently Asked Questions